MCID: 3HY005
MIFTS: 54

3-Hydroxyacyl-Coa Dehydrogenase Deficiency malady

Genetic diseases, Neuronal diseases, Endocrine diseases, Rare diseases categories

Summaries for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Sources:
22Genetics Home Reference, 66Wikipedia, 48OMIM, 34MalaCards
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Genetics Home Reference:22 3-hydroxyacyl-CoA dehydrogenase deficiency is an inherited condition that prevents the body from converting certain fats to energy, particularly during prolonged periods without food (fasting).

MalaCards: 3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as schad deficiency, is related to hypoglycemia and hyperinsulinism. An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (hydroxyacyl-CoA dehydrogenase), and among its related pathways are Lysine degradation and Butanoate metabolism. The compounds (S)-3-hydroxypalmitoleoyl-CoA and (S)-Hydroxyhexanoyl-CoA have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and brain, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:66 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (HADH deficiency) is a rare condition that prevents... more...

Description from OMIM:48 231530,609975

Aliases & Classifications for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Sources:
22Genetics Home Reference, 50Orphanet, 48OMIM, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
schad deficiency:
Inheritance: Autosomal recessive; Prevalence: <1/1000000; Age of onset: Neonatal/infancy; Age of death: Before age 5


Aliases & Descriptions:

3-hydroxyacyl-coa dehydrogenase deficiency 22 48 50
schad deficiency 22 50
hadh deficiency 22 50
hyperinsulinemic hypoglycemia due to short chain 3-hydroxylacyl-coa dehydrogenase deficiency 50
hyperinsulinism due to short chain 3-hydroxylacyl-coa dehydrogenase deficiency 50
l-3-alpha-hydroxyacyl-coa dehydrogenase, short chain, deficiency 22
3-alpha-hydroxyacyl-coenzyme a dehydrogenase deficiency 22
hyperinsulinism due to glutamodehydrogenase deficiency 50
3-hydroxyacyl-coenzyme a dehydrogenase deficiency 22
deficiency of 3-hydroxyacyl-coa dehydrogenase 22
hyperinsulinism due to schad deficiency 50
hyperinsulinism due to hadh deficiency 50
m/schad deficiency 22
hadhsc deficiency 22
had deficiency 22


External Ids:

UMLS via Orphanet64 C1291230
SNOMED-CT via Orphanet60 124122005
ICD10 via Orphanet27 E71.3

Related Diseases for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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18GeneCards, 19GeneDecks
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Diseases related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.6HADH, HADHA, INS, ACADVL, GLUD1, GCK
2hyperinsulinism30.6GCK, GLUD1, MTTP, INS
3hyperinsulinemic hypoglycemia30.5GCK, GLUD1, INS, HADH
4lchad deficiency10.6
5hyperinsulinism due to glutamodehydrogenase deficiency10.6
6pigmentary retinopathy10.5
7fatty acid oxidation disorders10.5
8hypoparathyroidism10.4
9choroiditis10.4
10cataract10.4
11cholestasis10.4
12dilated cardiomyopathy10.4
13liver cirrhosis10.4
14liver disease10.4
15retinitis10.4
16developmental disabilities10.4
173-alpha hydroxyacyl-coa dehydrogenase deficiency10.4
18acute fatty liver of pregnancy10.4
1917-beta-hydroxysteroid dehydrogenase x deficiency10.4
203-hydroxyacyl-coenzyme a dehydrogenase deficiency10.4
21medium-chain acyl-coenzyme a dehydrogenase deficiency10.1ACADVL, HADHA
22sudden infant death syndrome10.0ACADVL, HADHA
23sudden cardiac death multi-gene panels10.0HADHA, ACADVL
24permanent neonatal diabetes mellitus10.0INS, GCK
25neonatal diabetes mellitus10.0INS, GCK
26maturity-onset diabetes of the young10.0INS, GCK
27abetalipoproteinemia10.0HADHA, MTTP
28hyperammonemia multi-gene panels10.0GCK, GLUD1
29hyperuricemia10.0INS, GCK
30type 1 diabetes mellitus10.0INS, GCK
31gestational diabetes10.0GCK, INS
32myopathy10.0ACADVL, INS, HADHA
33familial hyperinsulinism10.0HADH, GLUD1, GCK
34glucose intolerance10.0INS, GCK
35fatty liver disease10.0MTTP, INS
36insulinoma10.0GCK, GLUD1, INS
37familial hyperlipidemia10.0MTTP, INS
38hypertriglyceridemia9.9MTTP, INS
39type 2 diabetes mellitus9.9GCK, MTTP, INS
40insulin resistance9.9GCK, MTTP, INS
41galactosemia9.9HADHA, INS, MTTP, GLUD1
42obesity9.9GCK, MTTP, INS
43metabolic syndrome x9.9HADHA, INS, ACADVL, GLUD1, GCK

Graphical network of the top 20 diseases related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:



Diseases related to 3-hydroxyacyl-coa dehydrogenase deficiency

Symptoms for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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48OMIM
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Symptoms by clinical synopsis from OMIM:

231530

Clinical features from OMIM:

231530,609975

Drugs & Therapeutics for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Drug clinical trials:

Search ClinicalTrials for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Search NIH Clinical Center for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Search CenterWatch for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Genetic Tests for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Anatomical Context for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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34MalaCards
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MalaCards organs/tissues related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:

34
Liver, Eye, Brain, Skeletal muscle, Fetal liver

Animal Models for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5GCK, GLUD1, INS, HADH
2MP:00053678.3HADH, HADHA, INS, GCK
3MP:00053707.6HADHA, INS, MTTP, ACADVL, GCK
4MP:00053786.9GCK, HADH, HADHA, INS, MTTP, ACADVL
5MP:00053766.8HADH, HADHA, INS, MTTP, ACADVL, GLUD1

Publications for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Sources:
53PubMed
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Articles related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Prevalence of Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency in Estonia. (23430857)
2012
2
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: the clinical relevance of an early diagnosis and report of four new cases. (21347589)
2011
3
A comprehensive HADHA c.1528G&gt;C frequency study reveals high prevalence of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Poland. (20814823)
2010
4
Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. (20670938)
2010
5
Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency and choroidal neovascularization]. (19107076)
2008
6
Ocular characteristics in 10 children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a cross-sectional study with long-term follow-up. (18162058)
2008
7
Ophthalmologic abnormalities in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: presentation of a long-term survivor. (18465739)
2008
8
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency with inadvertent caries in infants. (17181583)
2007
9
Ten year follow up of pigmentary retinopathy associated with 3-hydroxyacyl-CoA dehydrogenase deficiency. (16167072)
2006
10
Mitochondrial fatty acid beta-oxidation in the human eye and brain: implications for the retinopathy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (15347768)
2004
11
Cataract in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD). (12660866)
2003
12
Striking improvement of muscle strength under creatine therapy in a patient with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (12872842)
2003
13
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle? (14641012)
2003
14
Optimal dietary therapy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (12809642)
2003
15
Plasma and erythrocyte fatty acid concentrations in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (12971430)
2003
16
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: clinical presentation and follow-up of 50 patients. (11773547)
2002
17
LCHAD (long-chain 3-hydroxyacyl-CoA dehydrogenase) deficiency as a cause of sudden death of a three months old infant]. (12637776)
2002
18
Feeding difficulties in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (11719334)
2001
19
Preimplantation diagnosis for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (12537820)
2001
20
Stable pigmentary retinopathy in a child with 3-hydroxyacyl-CoA dehydrogenase deficiency. (11040918)
2000
21
Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders. (10682306)
2000
22
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: variable expressivity of maternal illness during pregnancy and unusual presentation with infantile cholestasis and hypocalcaemia. (10518281)
1999
23
Docosahexaenoic acid and retinal function in children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (10384386)
1999
24
Inherited long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and a fetal-maternal interaction cause maternal liver disease and other pregnancy complications. (10331463)
1999
25
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a case example in developmental disabilities. (10638050)
1999
26
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: neonatal manifestation at the first day of life presenting with tachypnoea. (10518285)
1999
27
Neonatal diagnosis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and implications for newborn screening by tandem mass spectrometry. (10518286)
1999
28
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (10229030)
1999
29
Ophthalmic pathology in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. (9663844)
1998
30
Ophthalmologic findings in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation: a new type of hereditary metabolic chorioretinopathy. (9593380)
1998
31
Clinical, biochemical, and morphologic investigations of a case of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (9240910)
1997
32
Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. (9185222)
1997
33
Molecular basis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of two new mutations. (9266371)
1997
34
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a new method to identify the G1528C mutation in genomic DNA showing its high frequency (approximately 90%) and identification of a new mutation (T2198C). (8739956)
1996
35
The clinical spectrum of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (8736409)
1996
36
Pathology of skeletal muscle and impaired respiratory chain function in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency with the G1528C mutation. (8938697)
1996
37
Common missense mutation G1528C in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Characterization and expression of the mutant protein, mutation analysis on genomic DNA and chromosomal localization of the mitochondrial trifunctional protein alpha subunit gene. (8770876)
1996
38
Lethal dilated cardiomyopathy due to long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (8803786)
1996
39
Medium-chain triglyceride loading has no diagnostic power in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (8803788)
1996
40
Clinical and biochemical presentation of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (7564259)
1995
41
The molecular basis of pediatric long chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with maternal acute fatty liver of pregnancy. (7846063)
1995
42
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: high frequency of the G1528C mutation with no apparent correlation with the clinical phenotype. (7564258)
1995
43
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a severe fatty acid oxidation disorder. (7813533)
1994
44
Long-chain 3-hydroxyacyl-CoA dehydrogenase in chorionic villi, fetal liver and fibroblasts and prenatal diagnosis of 3-hydroxyacyl-CoA dehydrogenase deficiency. (7967472)
1994
45
Molecular basis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of the major disease-causing mutation in the alpha-subunit of the mitochondrial trifunctional protein. (7811722)
1994
46
First report of prenatal diagnosis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in a pregnancy at risk. (8372080)
1993
47
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: different clinical expression in three unrelated patients. (1770784)
1991
48
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (1830138)
1991
49
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (1779613)
1991
50
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of a new inborn error of mitochondrial fatty acid beta-oxidation. (2122092)
1990

Variations for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:

65
id Symbol AA change Variation ID SNP ID
1HADHp.Ala40ThrVAR_024079
2HADHp.Asp57GluVAR_024080

Clinvar genetic disease variations for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency:

1
id Gene Name Type Significance SNP ID Assembly Location
1HADHNM_005327.4(HADH): c.118G> A (p.Ala40Thr)single nucleotide variantPathogenicrs137853101GRCh37Chr 4, 108911206: 108911206
2HADHNM_005327.4(HADH): c.171C> A (p.Asp57Glu)single nucleotide variantPathogenicrs137853102GRCh37Chr 4, 108930953: 108930953

Expression for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Search GEO for disease gene expression data for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency.

Pathways for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 61Thomson Reuters
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Pathways related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HADH, HADHA
2
Show member pathways
9.8HADH, HADHA
3
Show member pathways
9.8HADH, HADHA
4
Show member pathways
oleate biosynthesis II (animals)39
9.8HADHA, HADH
5
Show member pathways
9.3HADH, HADHA, HSD17B10
6
Show member pathways
fatty acid beta-oxidation I39
eicosapentaenoate biosynthesis II (metazoa)39
gamma-linolenate biosynthesis II (animals)39
fatty acid activation39
9.3HSD17B10, HADHA, HADH
7
Show member pathways
beta-alanine degradation I39
valine degradation I39
pyruvate fermentation to lactate39
isoleucine degradation I39
9.3HSD17B10, HADHA, HADH
8
Show member pathways
9.3GCK, INS
9
Show member pathways
9.3GCK, INS
10
Show member pathways
9.3GCK, INS
11
Show member pathways
9.3ACADVL, HADHA, HADH
12
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)39
Fatty Acid Beta Oxidation39
9.3HADH, HADHA, ACADVL
13
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.3ACADVL, HADHA, HADH
148.5HADH, INS, ACADVL, GCK
15
Show member pathways
6.4GCK, HADH, HADHA, INS, HSD17B10, MTTP

Compounds for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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25HMDB, 46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(S)-3-hydroxypalmitoleoyl-CoA2510.1HSD17B10, HADH
2(S)-Hydroxyhexanoyl-CoA2510.1HADHA, HADH
320-CoA-20-oxo-18R-hydroxyleucotriene B42510.1HADH, HSD17B10
418,20-Dioxo-20-CoA-leukotriene B42510.1HADH, HSD17B10
5(S)-Hydroxydecanoyl-CoA2510.1HADH, HADHA
616,18-Oxo-18-CoA-dinor-LTE42510.1HSD17B10, HADH
7(S)-3-Hydroxytetradecanoyl-CoA2510.1HADH, HADHA
83(S)-3-hydroxydodecen-(5Z)-oyl-CoA2510.1HSD17B10, HADH
9(S)-Hydroxyoctanoyl-CoA2510.1HADHA, HADH
10CoA-20-COOH-18-oxo-LTE42510.1HADH, HSD17B10
11(S)-3-Hydroxydodecanoyl-CoA2510.1HADH, HADHA
123-Oxotetradecanoyl-CoA2510.0HADH, HADHA
133-Oxododecanoyl-CoA2510.0HADHA, HADH
142-Methylacetoacetyl-CoA2510.0HSD17B10, HADH
153-Oxodecanoyl-CoA2510.0HADHA, HADH
16(S)-3-Hydroxyhexadecanoyl-CoA2510.0HADH, HADHA
173-Oxohexanoyl-CoA259.9HADHA, HADH
182-methyl-3-hydroxybutyryl-coa46 2510.8HSD17B10, HADH, HADHA
19(3S)-3-Hydroxyadipyl-CoA259.8HSD17B10, HADH, HADHA
203-Oxohexadecanoyl-CoA259.8HADHA, HADH, HSD17B10
213-Oxooctanoyl-CoA259.8HADH, HADHA, HSD17B10
22Acetoacetyl-CoA259.8HADH, HADHA, HSD17B10
23chromium picolinate469.7GCK, INS
24alpha-ketoisocaproate469.6GCK, GLUD1
25acetyl-l-carnitine469.5HADHA, ACADVL
26nad+469.5HSD17B10, HADH, GLUD1
27preproinsulin469.4INS, GCK
28i-app469.4GCK, INS
29incretin469.3GCK, INS
30Heptanoyl-CoA259.3HSD17B10, HADH, HADHA, ACADVL
31palmitate469.3HADHA, INS, ACADVL
32nad30 2510.2GLUD1, HADH, HADHA, HSD17B10
33sulfonylurea469.2GLUD1, INS, GCK
34tolbutamide46 30 52 1212.2GLUD1, INS, GCK
35beta-hydroxybutyrate469.1INS, GLUD1
36citrate469.0GLUD1, GCK, HADHA, HSD17B10
37katp468.9HADH, INS, GLUD1, GCK
38diazoxide46 62 30 1211.9HADH, GLUD1, GCK, INS
39acetyl-coa46 259.9GCK, GLUD1, ACADVL, HADHA
40glycerol46 25 1210.8GCK, GLUD1, INS
41lactate468.7INS, HADHA, GCK, GLUD1
42nadh46 25 1210.6HSD17B10, HADH, HADHA, GLUD1, GCK
43creatinine468.4GCK, HADHA, INS, ACADVL, GLUD1
44glutamate468.1HADH, GCK, GLUD1, HSD17B10, INS, HADHA
45alanine468.0HADHA, INS, MTTP, GLUD1, GCK
46acyl-coa468.0MTTP, HSD17B10, HADH, ACADVL, GLUD1, HADHA
47carnitine467.9GLUD1, HADH, HADHA, INS, MTTP, ACADVL
48lipid467.7MTTP, ACADVL, HSD17B10, INS, HADHA, GCK
49glucose467.3GCK, ACADVL, HADH, HADHA, INS, MTTP
50fatty acid466.9GCK, INS, GLUD1, ACADVL, MTTP, HSD17B10

GO Terms for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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17Gene Ontology
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Cellular components related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial nucleoidGO:0426459.6ACADVL, HADHA
2mitochondrial matrixGO:0057598.6HADH, HSD17B10, ACADVL, GLUD1
3mitochondrial inner membraneGO:0057438.6HADH, HADHA, HSD17B10, ACADVL
4mitochondrionGO:0057397.7GCK, HADH, HADHA, HSD17B10, ACADVL, GLUD1

Biological processes related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to insulinGO:0328689.8HADH, HADHA
2negative regulation of gluconeogenesisGO:0457219.6GCK, INS
3fatty acid beta-oxidationGO:0066359.5HADH, HADHA, ACADVL
4positive regulation of glycolytic processGO:0458219.5GCK, INS
5positive regulation of glycogen biosynthetic processGO:0457259.5GCK, INS
6cellular lipid metabolic processGO:0442559.5HADH, HADHA, ACADVL
7positive regulation of insulin secretionGO:0320249.4GCK, GLUD1
8endocrine pancreas developmentGO:0310189.4GCK, INS
9regulation of insulin secretionGO:0507969.3GCK, INS
10glucose transportGO:0157589.2GCK, INS
11glucose homeostasisGO:0425939.0GCK, INS
12small molecule metabolic processGO:0442816.7GCK, GLUD1, ACADVL, MTTP, HSD17B10, INS

Molecular functions related to 3-Hydroxyacyl-Coa Dehydrogenase Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-hydroxyacyl-CoA dehydrogenase activityGO:0038579.7HADHA, HADH
2ADP bindingGO:0435319.3GCK, GLUD1
3NAD+ bindingGO:0704039.3GLUD1, HADH

Products for genes affiliated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for 3-Hydroxyacyl-Coa Dehydrogenase Deficiency

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet