MCID: 3MT007
MIFTS: 34

3-Methylglutaconic Aciduria malady

Categories: Genetic diseases, Metabolic diseases, Rare diseases, Cardiovascular diseases, Eye diseases

Aliases & Classifications for 3-Methylglutaconic Aciduria

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Summaries for 3-Methylglutaconic Aciduria

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Wikipedia:68 3-Methylglutaconic aciduria (MGA) is used to describe at least five disorders that impair the body\'s... more...

MalaCards based summary: 3-Methylglutaconic Aciduria is related to 3-methylglutaconic aciduria, type iii and 3-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia. An important gene associated with 3-Methylglutaconic Aciduria is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)). Affiliated tissues include bone, breast and pancreas.

Related Diseases for 3-Methylglutaconic Aciduria

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Diseases in the 3-Methylglutaconic Aciduria family:

3-Methylglutaconic Aciduria, Type V 3-Methylglutaconic Aciduria, Type I
3-Methylglutaconic Aciduria, Type Iii

Diseases related to 3-Methylglutaconic Aciduria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
13-methylglutaconic aciduria, type iii12.9
23-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia12.8
33-methylglutaconic aciduria with deafness, encephalopathy, and leigh-like syndrome12.8
43-methylglutaconic aciduria, type i12.8
53-methylglutaconic aciduria, type v12.7
6barth syndrome12.2
7megdel syndrome12.2
8dcma syndrome11.9
9not otherwise specified 3-mga-uria type11.7
10optic atrophy 3 with cataract11.6
11optic atrophy plus syndrome11.5
12endotheliitis10.5
13mitochondrial dna depletion syndrome 4a10.5
14mitochondrial complex v deficiency, nuclear type 110.5
15systemic lupus erythematosus10.4
16hiv-110.4
17lupus erythematosus10.4
18schizophrenia10.2
19porphyria cutanea tarda10.2
20malaria10.2
21lung cancer10.2
22prostate cancer10.2
23thyroid hormone resistance10.2
24alcohol dependence10.2
25leprosy10.2
26celiac disease10.2
27cystic fibrosis10.2
28endometrial cancer10.2
29gitelman syndrome10.2
30congenital hypomyelination neuropathy10.2
31crohn's disease10.2
32gastric cancer10.2
33hepatitis10.2
34joint disorders10.2
35leukemia10.2
36retinal vein occlusion10.2
37chorioamnionitis10.2
38blastoma10.2
39migraine with aura10.2
40sleeping sickness10.2
41tuberculoid leprosy10.2
42epidemic pleurodynia10.2
43pulmonary alveolar proteinosis10.2
44leiomyoma10.2
45balanitis10.2
46porphyria10.2
47balanitis xerotica obliterans10.2
48dracunculiasis10.2
49prostatitis10.2
50melanotic neuroectodermal tumor10.2

Graphical network of the top 20 diseases related to 3-Methylglutaconic Aciduria:



Diseases related to 3-methylglutaconic aciduria

Symptoms for 3-Methylglutaconic Aciduria

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Drugs & Therapeutics for 3-Methylglutaconic Aciduria

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for 3-Methylglutaconic Aciduria

Genetic Tests for 3-Methylglutaconic Aciduria

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Anatomical Context for 3-Methylglutaconic Aciduria

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MalaCards organs/tissues related to 3-Methylglutaconic Aciduria:

33
Bone, Breast, Pancreas, Heart, Myeloid, Endothelial, Skin

Animal Models for 3-Methylglutaconic Aciduria or affiliated genes

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Publications for 3-Methylglutaconic Aciduria

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Articles related to 3-Methylglutaconic Aciduria:

(show top 50)    (show all 83)
idTitleAuthorsYear
1
Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris. (26074471)
2015
2
Multiple halo nevi subsequent to a short period of sunbathing. (25703501)
2015
3
Race/ethnicity and the prevalence of thyrotoxicosis in young Americans. (25744381)
2015
4
Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. (24716743)
2014
5
Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India). (24984237)
2014
6
Associations between presence of relevant information in referrals to radiology and prevalence rates in patients with suspected pulmonary embolism. (23931425)
2013
7
"Huge axillary mass - neurofibroma brachial plexus". (24426510)
2013
8
Disparity between ultrasound and clinical findings in psoriatic arthritis. (23740228)
2013
9
Cystoid macular edema without leakage secondary to nab-Paclitaxel (Abraxane): clinical experience with intravitreal bevacizumab. (23061416)
2013
10
Vertebral artery dissection and cerebral infarction in a patient with recurrent ovarian cancer receiving bevacizumab. (24371692)
2013
11
Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis. (22533697)
2012
12
Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression. (23284647)
2012
13
Isolated intramedullary spinal cord cysticercosis. (22870160)
2012
14
Prevention of severe acute pancreatitis with octreotide in obese patients: a prospective multi-center randomized controlled trial. (23086244)
2012
15
Correlation between elevation of serum antinuclear antibody titer and decreased therapeutic efficacy in the treatment of BehAset's disease with infliximab. (22234352)
2012
16
The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity. (21917959)
2011
17
Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation. (20385240)
2011
18
Bone marrow aspirate and trephine biopsy findings in lymphoplasmacytic lymphoma. (21328425)
2011
19
Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. (20195526)
2010
20
Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives? (19772915)
2010
21
Neoadjuvant chemotherapy/gefitinib followed by concurrent chemotherapy/radiation therapy/gefitinib for patients with locally advanced squamous carcinoma of the head and neck. (19288572)
2009
22
Effect of different biomaterials on the expression pattern of the transcription factor Ets2 in bone-like constructs. (19318269)
2009
23
Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. (18791800)
2008
24
Endocannabinoids and the regulation of bone metabolism. (18426503)
2008
25
Cervical necrotizing fasciitis. (18317168)
2008
26
QT dispersion and diastolic functions in differential diagnosis of primary mitral valve prolapse and rheumatic mitral valve prolapse. (17917767)
2008
27
Differential allelic expression in leukoblast from patients with acute myeloid leukemia suggests genetic regulation of CDA, DCK, NT5C2, NT5C3, and TP53. (18775979)
2008
28
Trichotillomania and Pathologic Skin Picking: clinical comparison with an examination of comorbidity. (18568576)
2008
29
Early-onset ophthalmoplegia in Leigh-like syndrome due to NDUFV1 mutations. (17162199)
2007
30
Loss of TP53-DNA interaction induced by p.C135R in lung cancer. (17914575)
2007
31
Insulin resistance as predictor of the angiographic severity and extent of coronary artery disease. (17453676)
2007
32
Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. (17531965)
2007
33
Molluscicidal effect of three monoterpenes oils on schistosomiasis and fascioliasis vector snails in Egypt. (16927871)
2006
34
Influence of dominant HIV-1 epitopes on HLA-A3/peptide complex formation. (17116886)
2006
35
Is resting heart rate variability following 12 hours of abstinence from smoking similar to that of non smokers? (16850910)
2006
36
Targeted degradation of beta-catenin by chimeric F-box fusion proteins. (14706645)
2004
37
Parkinson's disease-associated alpha-synuclein is a calmodulin substrate. (12610000)
2003
38
Intraperitoneal ondansetron hydrochloride for intractable nausea and vomiting due to diabetic gastroparesis in a patient on peritoneal dialysis. (12322834)
2002
39
cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12. (11007799)
2000
40
VHL gene inactivation in an endolymphatic sac tumor associated with von Hippel-Lindau disease. (10408561)
1999
41
Production of surfactant protein C in the baculovirus expression system: the information required for correct folding and palmitoylation of SP-C is contained within the mature sequence. (9889385)
1999
42
What is the radiologist's current role in the diagnosis and treatment of sexual impotence in men? (8010221)
1994
43
Sick building syndrome. (8332159)
1993
44
Molecular genetics of metachromatic leukodystrophy. (1687778)
1991
45
A chart review study of late-onset and early-onset schizophrenia. (2574011)
1989
46
Magnetic resonance imaging of restrictive cardiomyopathy. (3812321)
1987
47
Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man. (3858090)
1985
48
Lymphomatoid granulomatosis. (489214)
1979
49
Annular pancreas and jaundice in the newborn: report of a case. (13814435)
1959
50

Variations for 3-Methylglutaconic Aciduria

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Clinvar genetic disease variations for 3-Methylglutaconic Aciduria:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MT-TL1m.3243A> Gsingle nucleotide variantPathogenicrs199474657GRCh37Chr MT, 3243: 3243

Expression for genes affiliated with 3-Methylglutaconic Aciduria

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Search GEO for disease gene expression data for 3-Methylglutaconic Aciduria.

Pathways for genes affiliated with 3-Methylglutaconic Aciduria

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GO Terms for genes affiliated with 3-Methylglutaconic Aciduria

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Cellular components related to 3-Methylglutaconic Aciduria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057399.1DNAJC19, TMEM70

Sources for 3-Methylglutaconic Aciduria

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet