3MGA
MCID: 3MT007
MIFTS: 22

3-Methylglutaconic Aciduria (3MGA) malady

Summaries for 3-Methylglutaconic Aciduria

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21Genetics Home Reference, 64Wikipedia, 33MalaCards
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Genetics Home Reference:21 The name 3-methylglutaconic aciduria is used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria). As a result of this impairment, pathways that aid in mitochondrial function are disrupted and large amounts of particular acids (3-methylglutaconic acid and 3-methylglutaric acid) build up and are excreted in the urine.

MalaCards: 3-Methylglutaconic Aciduria, also known as 3-@methylglutaconic aciduria, type i, is related to barth syndrome and opa3-related 3-methylglutaconic aciduria. An important gene associated with 3-Methylglutaconic Aciduria is OPA3 (optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)), and among its related pathways are Mitochondrial Protein Import and Branched-chain amino acid catabolism. The compounds ryanodine and 3-methylglutaconic acid have been mentioned in the context of this disorder.

Wikipedia:64 3-Methylglutaconic aciduria (MGA) is used to describe at least five disorders that impair the body\'s... more...

Aliases & Classifications for 3-Methylglutaconic Aciduria

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21Genetics Home Reference, 61UMLS
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Aliases & Descriptions:

3-methylglutaconic aciduria 21
3-@methylglutaconic aciduria, type i 61
3mga 21


Related Diseases for 3-Methylglutaconic Aciduria

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to 3-Methylglutaconic Aciduria:



Diseases related to 3-methylglutaconic aciduria

Clinical Features for 3-Methylglutaconic Aciduria

Drugs & Therapeutics for 3-Methylglutaconic Aciduria

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for 3-Methylglutaconic Aciduria

Drug clinical trials:

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Search NIH Clinical Center for 3-Methylglutaconic Aciduria

Search CenterWatch for 3-Methylglutaconic Aciduria

Genetic Tests for 3-Methylglutaconic Aciduria

Anatomical Context for 3-Methylglutaconic Aciduria

Animal Models for 3-Methylglutaconic Aciduria or affiliated genes

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28inGenious Targeting Laboratory
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Publications for 3-Methylglutaconic Aciduria

Genetic Variations for 3-Methylglutaconic Aciduria

Expression for genes affiliated with 3-Methylglutaconic Aciduria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with 3-Methylglutaconic Aciduria

Search GEO for disease gene expression data for 3-Methylglutaconic Aciduria.

Pathways for genes affiliated with 3-Methylglutaconic Aciduria

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to 3-Methylglutaconic Aciduria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TAZ, DNAJC19
2
Hide members
9.2MCCC2, EHHADH, AUH

Compounds for genes affiliated with 3-Methylglutaconic Aciduria

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to 3-Methylglutaconic Aciduria according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ryanodine45 29 6011.6RYR1, DMPK
23-methylglutaconic acid459.5OPA3, AUH
33-methylglutaconyl-coa45 2410.2MCCC2, EHHADH, AUH
43-methylcrotonyl-coa45 2410.1AUH, EHHADH, MCCC2

GO Terms for genes affiliated with 3-Methylglutaconic Aciduria

Sources:
16Gene Ontology
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Cellular components related to 3-Methylglutaconic Aciduria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcoplasmic reticulum membraneGO:0330179.3RYR1, DMPK
2mitochondrial inner membraneGO:0057439.1TMEM70, TAZ, DNAJC19
3mitochondrionGO:0057397.7SERAC1, AUH, OPA3, EHHADH, DNAJC19, MCCC2

Biological processes related to 3-Methylglutaconic Aciduria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1leucine catabolic processGO:0065529.6MCCC2, AUH
2muscle contractionGO:0069369.5TAZ, RYR1
3branched-chain amino acid catabolic processGO:0090839.4MCCC2, AUH

Molecular functions related to 3-Methylglutaconic Aciduria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enoyl-CoA hydratase activityGO:0043009.6EHHADH, AUH

Products for genes affiliated with 3-Methylglutaconic Aciduria

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for 3-Methylglutaconic Aciduria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet