MCID: 5FL001
MIFTS: 23

5-Fluorouracil Toxicity malady

Summaries for 5-Fluorouracil Toxicity

Sources:
47OMIM, 33MalaCards
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MalaCards: 5-Fluorouracil Toxicity, also known as 5-@fluorouracil toxicity, is related to dihydropyrimidine dehydrogenase deficiency and colorectal cancer. An important gene associated with 5-Fluorouracil Toxicity is DPYD (dihydropyrimidine dehydrogenase), and among its related pathways are Beta-alanine metabolism and Coenzyme A biosynthesis. The compounds atazanavir and 5,6-dihydrothymine have been mentioned in the context of this disorder.

Description from OMIM:47 274270

Aliases & Classifications for 5-Fluorouracil Toxicity

Sources:
47OMIM, 61UMLS
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Aliases & Descriptions:

5-fluorouracil toxicity 47
5-@fluorouracil toxicity 61


Related Diseases for 5-Fluorouracil Toxicity

Sources:
17GeneCards, 18GeneDecks
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Diseases related to 5-Fluorouracil Toxicity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1dihydropyrimidine dehydrogenase deficiency30.6DPYD, DPYS
2colorectal cancer30.6ABCB1, TYMS, DPYD
3adenocarcinoma30.0DPYD, TYMS, ABCB1, UGT1A1
4osteogenesis imperfecta10.2
5toxic optic neuropathy10.2
6cicatricial ectropion10.1
7toxic encephalopathy10.1
8dihydropyrimidinase deficiency10.1
9cervical cancer10.0DPYD
10sarcoma10.0ABCB1
11hepatitis10.0UGT1A1
12prostate cancer10.0DPYD
13adult acute lymphocytic leukemia10.0TYMS
14bladder carcinoma10.0TYMS
15gilbert syndrome10.0UGT1A1, DPYD
16gallbladder cancer10.0DPYD, TYMS
17adenoma10.0MTHFR
18pancreatic cancer10.0TYMS, DPYD
19rectum cancer10.0DPYD, TYMS
20leukemia, acute nonlymphocytic10.0TYMS, ABCB1
21kidney rhabdoid cancer10.0DPYD, ABCB1
22down syndrome10.0MTHFR
23factor vii deficiency10.0UGT1A1, TYMS
24schizophrenia10.0MTHFR
25lung cancer10.0ABCB1, TYMS
26biliary tract cancer10.0TYMS, DPYD
27folic acid deficiency anemia10.0MTHFR, TYMS
28leukopenia10.0DPYD, UGT1A1, TYMS
29hepatocellular carcinoma10.0UGT1A1, ABCB1, DPYD
30neutropenia10.0UGT1A1, DPYD, TYMS
31diarrhea10.0TYMS, DPYD, UGT1A1
32ovarian cancer10.0ABCB1, DPYD, TYMS
33stomach cancer10.0DPYD, ABCB1, TYMS
34acute leukemia10.0ABCB1, MTHFR
35colon cancer10.0ABCB1, DPYD, TYMS
36acute lymphoblastic leukemia, childhood10.0MTHFR, TYMS, ABCB1
37non-small cell lung carcinoma10.0DPYD, ABCB1, UGT1A1, TYMS
38breast cancer10.0DPYD, TYMS, ABCB1
39acute lymphocytic leukemia10.0MTHFR, TYMS, ABCB1, UGT1A1

Graphical network of the top 20 diseases related to 5-Fluorouracil Toxicity:



Diseases related to 5-fluorouracil toxicity

Clinical Features for 5-Fluorouracil Toxicity

Sources:
47OMIM
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Clinical features from OMIM:

274270

Drugs & Therapeutics for 5-Fluorouracil Toxicity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for 5-Fluorouracil Toxicity

Drug clinical trials:

Search ClinicalTrials for 5-Fluorouracil Toxicity

Search NIH Clinical Center for 5-Fluorouracil Toxicity

Search CenterWatch for 5-Fluorouracil Toxicity

Genetic Tests for 5-Fluorouracil Toxicity

Anatomical Context for 5-Fluorouracil Toxicity

Animal Models for 5-Fluorouracil Toxicity or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for 5-Fluorouracil Toxicity

Genetic Variations for 5-Fluorouracil Toxicity

Expression for genes affiliated with 5-Fluorouracil Toxicity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with 5-Fluorouracil Toxicity

Search GEO for disease gene expression data for 5-Fluorouracil Toxicity.

Pathways for genes affiliated with 5-Fluorouracil Toxicity

Sources:
12EMD Millipore, 54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database
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Pathways related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DPYS, DPYD
2
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9.6DPYS, DPYD
39.6DPYD, DPYS
4
Acetaminophen metabolism
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9.4ABCB1, UGT1A1
59.4UGT1A1, ABCB1
6
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9.4ABCB1, UGT1A1
7
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9.4UGT1A1, ABCB1
8
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9.4ABCB1, UGT1A1
9
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9.4UGT1A1, ABCB1
10
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9.1DPYD, DPYS, UGT1A1
119.0MTHFR, TYMS
12
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9.0TYMS, MTHFR
13
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9.0TYMS, MTHFR
14
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9.0DPYS, DPYD, TYMS
15
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9.0TYMS, DPYD, DPYS
16
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9.0DPYS, DPYD, TYMS
17
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8.2TYMS, DPYD, DPYS, MTHFR
18
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7.6UGT1A1, MTHFR, DPYS, DPYD, TYMS

Compounds for genes affiliated with 5-Fluorouracil Toxicity

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1atazanavir45 50 1112.2UGT1A1
25,6-dihydrothymine4510.0DPYD, DPYS
3dihydrouracil45 2410.9DPYD, DPYS
4tegafur-uracil459.8DPYD, TYMS
5eniluracil459.8TYMS, DPYD
6pyrimidine analogues509.8DPYD, TYMS
72-deoxyuridine-5-monophosphate459.8DPYD, TYMS
8indacaterol50 1110.8UGT1A1, ABCB1
9bvdu459.8TYMS, DPYD
105-fluoro-2-deoxyuridine-5-monophosphate459.8TYMS, DPYD
11idurd459.8TYMS, DPYD
12tegafur45 5010.7DPYD, TYMS
13nilotinib50 1110.7ABCB1, UGT1A1
14trimetrexate45 1110.6TYMS, ABCB1
15axitinib45 60 1111.5ABCB1, UGT1A1
165-deoxy-5-fluorouridine459.5DPYD, TYMS
17trimethoprim45 50 1111.5TYMS, ABCB1
18p-007459.4DPYD, MTHFR
19orotic acid45 11 2411.4TYMS, DPYD
20ch2h4folate459.4TYMS, MTHFR
21pyrimidine45 2410.3TYMS, DPYS, DPYD
22b vitamins459.3TYMS, MTHFR
23pemetrexed50 1110.3MTHFR, TYMS
24mitomycin c459.2ABCB1, DPYD, TYMS
25erlotinib45 50 1111.2ABCB1, UGT1A1, TYMS
26thymine45 2410.2DPYD, DPYS, MTHFR
27docetaxel45 50 60 1112.2ABCB1, DPYD, TYMS
286 mercaptopurine459.1UGT1A1, MTHFR, DPYD
29lamotrigine45 1110.1ABCB1, UGT1A1
30camptothecin45 60 1111.1DPYD, TYMS, ABCB1
31phenytoin45 50 29 1112.0MTHFR, ABCB1, UGT1A1
32carboplatin45 50 1110.8TYMS, MTHFR, ABCB1
33sn 3845 609.8UGT1A1, DPYD, ABCB1, TYMS
34quercetin45 60 11 2411.8UGT1A1, ABCB1, TYMS
35etoposide45 50 60 1111.8DPYD, UGT1A1, TYMS, ABCB1
36cyclophosphamide45 50 1110.6MTHFR, DPYD, ABCB1
37purine45 249.6DPYD, DPYS, MTHFR, TYMS
38capecitabine45 50 1110.5ABCB1, TYMS, DPYD, MTHFR
39thiopurine458.5UGT1A1, MTHFR, TYMS, DPYD
40taxane458.5ABCB1, TYMS, DPYD, MTHFR
41fluorouracil50 119.5TYMS, ABCB1, DPYD, MTHFR
42leucovorin45 50 1110.5MTHFR, DPYD, TYMS, UGT1A1
43gemcitabine45 50 1110.5ABCB1, MTHFR, DPYD, TYMS
44methotrexate45 50 1110.5TYMS, DPYD, MTHFR, ABCB1
45thymidine45 249.1TYMS, UGT1A1, DPYD, MTHFR, DPYS
46oxaliplatin45 50 1110.0DPYD, UGT1A1, TYMS, ABCB1, MTHFR
47irinotecan45 50 1110.0DPYD, TYMS, ABCB1, MTHFR, UGT1A1
48thymidylate458.0DPYD, TYMS, ABCB1, UGT1A1, MTHFR
49cisplatin45 50 60 1111.0TYMS, ABCB1, UGT1A1, MTHFR, DPYD
505fluorouracil457.6DPYD, UGT1A1, MTHFR, ABCB1, TYMS, DPYS

GO Terms for genes affiliated with 5-Fluorouracil Toxicity

Sources:
16Gene Ontology
See all sources

Biological processes related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1uracil catabolic processGO:0062129.8DPYS, DPYD
2thymine catabolic processGO:0062109.7DPYS, DPYD
3pyrimidine nucleobase catabolic processGO:0062089.6DPYD, DPYS
4pyrimidine nucleoside catabolic processGO:0461359.5DPYS, DPYD
5organ regenerationGO:0311009.3TYMS, UGT1A1
6pyrimidine nucleobase metabolic processGO:0062069.2TYMS, DPYD, DPYS
7nucleobase-containing small molecule metabolic processGO:0550869.1TYMS, DPYD, DPYS
8response to drugGO:0424938.5ABCB1, TYMS, UGT1A1
9small molecule metabolic processGO:0442817.3ABCB1, UGT1A1, MTHFR, DPYS, DPYD, TYMS

Products for genes affiliated with 5-Fluorouracil Toxicity

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for 5-Fluorouracil Toxicity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet