MCID: 5FL001
MIFTS: 28

5-Fluorouracil Toxicity malady

Summaries for 5-Fluorouracil Toxicity

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Sources:
46OMIM, 32MalaCards
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MalaCards: 5-Fluorouracil Toxicity, also known as 5-@fluorouracil toxicity, is related to dihydropyrimidine dehydrogenase deficiency and colorectal cancer. An important gene associated with 5-Fluorouracil Toxicity is DPYD (dihydropyrimidine dehydrogenase), and among its related pathways are Beta-alanine metabolism and Coenzyme A biosynthesis. The compounds atazanavir and 5,6-dihydrothymine have been mentioned in the context of this disorder.

Description from OMIM:46 274270

Aliases & Classifications for 5-Fluorouracil Toxicity

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46OMIM, 60UMLS
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Aliases & Descriptions:

5-fluorouracil toxicity 46
5-@fluorouracil toxicity 60


Related Diseases for 5-Fluorouracil Toxicity

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17GeneCards, 18GeneDecks
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Diseases related to 5-Fluorouracil Toxicity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1dihydropyrimidine dehydrogenase deficiency30.6DPYD, DPYS
2colorectal cancer30.6ABCB1, TYMS, DPYD
3breast cancer30.2DPYD, TYMS, ABCB1
4adenocarcinoma30.0DPYD, TYMS, ABCB1, UGT1A1
5osteogenesis imperfecta10.2
6toxic optic neuropathy10.2
7neuropathy10.2
8cicatricial ectropion10.0
9toxic encephalopathy10.0
10ectropion10.0
11lactic acidosis10.0
12cervical cancer10.0DPYD
13sarcoma10.0ABCB1
14hepatitis10.0UGT1A1
15prostate cancer10.0DPYD
16adult acute lymphocytic leukemia10.0TYMS
17bladder carcinoma10.0TYMS
18gilbert syndrome10.0UGT1A1, DPYD
19gallbladder cancer10.0DPYD, TYMS
20adenoma10.0MTHFR
21pancreatic cancer10.0TYMS, DPYD
22rectal neoplasm10.0DPYD, TYMS
23leukemia, acute nonlymphocytic10.0TYMS, ABCB1
24kidney rhabdoid cancer10.0DPYD, ABCB1
25down syndrome10.0MTHFR
26factor vii deficiency10.0UGT1A1, TYMS
27schizophrenia10.0MTHFR
28lung cancer10.0ABCB1, TYMS
29biliary tract neoplasm10.0TYMS, DPYD
30folic acid deficiency anemia10.0MTHFR, TYMS
31leukopenia10.0DPYD, UGT1A1, TYMS
32hepatocellular carcinoma10.0UGT1A1, ABCB1, DPYD
33neutropenia10.0UGT1A1, DPYD, TYMS
34diarrhea10.0TYMS, DPYD, UGT1A1
35ovarian cancer10.0ABCB1, DPYD, TYMS
36stomach cancer10.0DPYD, ABCB1, TYMS
37acute leukemia10.0ABCB1, MTHFR
38colon cancer10.0ABCB1, DPYD, TYMS
39acute lymphoblastic leukemia, childhood10.0MTHFR, TYMS, ABCB1
40non-small cell lung carcinoma10.0DPYD, ABCB1, UGT1A1, TYMS
41acute lymphocytic leukemia10.0MTHFR, TYMS, ABCB1, UGT1A1

Graphical network of the top 20 diseases related to 5-Fluorouracil Toxicity:



Diseases related to 5-fluorouracil toxicity

Clinical Features for 5-Fluorouracil Toxicity

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Sources:
46OMIM
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Clinical features from OMIM:

274270

Drugs & Therapeutics for 5-Fluorouracil Toxicity

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for 5-Fluorouracil Toxicity

Drug clinical trials:

Search ClinicalTrials for 5-Fluorouracil Toxicity

Search NIH Clinical Center for 5-Fluorouracil Toxicity

Search CenterWatch for 5-Fluorouracil Toxicity

Genetic Tests for 5-Fluorouracil Toxicity

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Anatomical Context for 5-Fluorouracil Toxicity

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Animal Models for 5-Fluorouracil Toxicity or affiliated genes

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Publications for 5-Fluorouracil Toxicity

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Genetic Variations for 5-Fluorouracil Toxicity

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for 5-Fluorouracil Toxicity:

62
id Symbol AA change Variation ID SNP ID
1DPYDp.Cys29ArgVAR_005173rs1801265
2DPYDp.Arg235TrpVAR_005174rs1801266
3DPYDp.Arg886HisVAR_005177rs1801267

Expression for genes affiliated with 5-Fluorouracil Toxicity

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with 5-Fluorouracil Toxicity

Search GEO for disease gene expression data for 5-Fluorouracil Toxicity.

Pathways for genes affiliated with 5-Fluorouracil Toxicity

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Sources:
12EMD Millipore, 53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DPYS, DPYD
2
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9.6DPYS, DPYD
39.6DPYD, DPYS
4
Acetaminophen metabolism
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9.4ABCB1, UGT1A1
59.4UGT1A1, ABCB1
6
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9.4ABCB1, UGT1A1
7
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9.4UGT1A1, ABCB1
8
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9.4ABCB1, UGT1A1
9
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9.4UGT1A1, ABCB1
10
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9.1DPYD, DPYS, UGT1A1
119.0MTHFR, TYMS
12
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9.0TYMS, MTHFR
13
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9.0TYMS, MTHFR
14
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9.0DPYS, DPYD, TYMS
15
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9.0TYMS, DPYD, DPYS
16
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9.0DPYS, DPYD, TYMS
17
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8.2TYMS, DPYD, DPYS, MTHFR
18
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7.6UGT1A1, MTHFR, DPYS, DPYD, TYMS

Compounds for genes affiliated with 5-Fluorouracil Toxicity

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1atazanavir44 49 1112.2UGT1A1
25,6-dihydrothymine4410.0DPYD, DPYS
3dihydrouracil44 2410.9DPYD, DPYS
4tegafur-uracil449.8DPYD, TYMS
5eniluracil449.8TYMS, DPYD
6pyrimidine analogues499.8DPYD, TYMS
72-deoxyuridine-5-monophosphate449.8DPYD, TYMS
8indacaterol49 1110.8UGT1A1, ABCB1
9bvdu449.8TYMS, DPYD
105-fluoro-2-deoxyuridine-5-monophosphate449.8TYMS, DPYD
11idurd449.8TYMS, DPYD
12tegafur44 4910.7DPYD, TYMS
13nilotinib49 1110.7ABCB1, UGT1A1
14trimetrexate44 1110.6TYMS, ABCB1
15axitinib44 59 1111.5ABCB1, UGT1A1
165-deoxy-5-fluorouridine449.5DPYD, TYMS
17trimethoprim44 49 1111.5TYMS, ABCB1
18p-007449.4DPYD, MTHFR
19orotic acid44 11 2411.4TYMS, DPYD
20ch2h4folate449.4TYMS, MTHFR
21pyrimidine44 2410.3TYMS, DPYS, DPYD
22b vitamins449.3TYMS, MTHFR
23pemetrexed49 1110.3MTHFR, TYMS
24mitomycin c449.2ABCB1, DPYD, TYMS
25erlotinib44 49 1111.2ABCB1, UGT1A1, TYMS
26thymine44 2410.2DPYD, DPYS, MTHFR
27docetaxel44 49 59 1112.2ABCB1, DPYD, TYMS
286 mercaptopurine449.1UGT1A1, MTHFR, DPYD
29lamotrigine44 1110.1ABCB1, UGT1A1
30camptothecin44 59 1111.1DPYD, TYMS, ABCB1
31phenytoin44 49 28 1112.0MTHFR, ABCB1, UGT1A1
32carboplatin44 49 1110.8TYMS, MTHFR, ABCB1
33sn 3844 599.8UGT1A1, DPYD, ABCB1, TYMS
34quercetin44 59 11 2411.8UGT1A1, ABCB1, TYMS
35etoposide44 49 59 1111.8DPYD, UGT1A1, TYMS, ABCB1
36cyclophosphamide44 49 1110.6MTHFR, DPYD, ABCB1
37purine44 249.6DPYD, DPYS, MTHFR, TYMS
38capecitabine44 49 1110.5ABCB1, TYMS, DPYD, MTHFR
39thiopurine448.5UGT1A1, MTHFR, TYMS, DPYD
40taxane448.5ABCB1, TYMS, DPYD, MTHFR
41fluorouracil49 119.5TYMS, ABCB1, DPYD, MTHFR
42leucovorin44 49 1110.5MTHFR, DPYD, TYMS, UGT1A1
43gemcitabine44 49 1110.5ABCB1, MTHFR, DPYD, TYMS
44methotrexate44 49 1110.5TYMS, DPYD, MTHFR, ABCB1
45thymidine44 249.1TYMS, UGT1A1, DPYD, MTHFR, DPYS
46oxaliplatin44 49 1110.0DPYD, UGT1A1, TYMS, ABCB1, MTHFR
47irinotecan44 49 1110.0DPYD, TYMS, ABCB1, MTHFR, UGT1A1
48thymidylate448.0DPYD, TYMS, ABCB1, UGT1A1, MTHFR
49cisplatin44 49 59 1111.0TYMS, ABCB1, UGT1A1, MTHFR, DPYD
505fluorouracil447.6DPYD, UGT1A1, MTHFR, ABCB1, TYMS, DPYS

GO Terms for genes affiliated with 5-Fluorouracil Toxicity

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16Gene Ontology
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Biological processes related to 5-Fluorouracil Toxicity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1uracil catabolic processGO:0062129.8DPYS, DPYD
2thymine catabolic processGO:0062109.7DPYS, DPYD
3pyrimidine nucleobase catabolic processGO:0062089.6DPYD, DPYS
4pyrimidine nucleoside catabolic processGO:0461359.5DPYS, DPYD
5organ regenerationGO:0311009.3TYMS, UGT1A1
6pyrimidine nucleobase metabolic processGO:0062069.2TYMS, DPYD, DPYS
7nucleobase-containing small molecule metabolic processGO:0550869.1TYMS, DPYD, DPYS
8response to drugGO:0424938.5ABCB1, TYMS, UGT1A1
9small molecule metabolic processGO:0442817.3ABCB1, UGT1A1, MTHFR, DPYS, DPYD, TYMS

Products for genes affiliated with 5-Fluorouracil Toxicity

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for 5-Fluorouracil Toxicity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet