Abdominal Aortic Aneurysm malady

NIH Rare Diseases: Abdominal aortic aneurysm occurs when the large blood vessel that supplies blood to the abdomen, pelvis, and legs becomes abnormally large or balloons outward. Aneurysms develop slowly over many years and often have no symptoms. If an aneurysm expands rapidly, tears open (ruptured aneurysm), or blood leaks along the wall of the vessel (aortic dissection), symptoms may develop suddenly. Symptoms may include abdominal pain or rigidity, nausea, vomiting, rapid heart rate, and/or clammy skin. The exact cause of abdominal aortic aneurysms is unknown, but they are most often seen in males over 60 who have one or more of the following risk factors: emphysema, high blood pressure, high cholesterol, obesity, or a history of smoking. Genetics may also play a role. If the aneurysm is small and there are no symptoms, periodic evaluation may be recommended. Aneurysms that cause symptoms usually require surgery to prevent complications. The goal of surgery is to prevent complications or symptoms from developing.³⁰

MalaCards: Abdominal Aortic Aneurysm, also known as aortic aneurysm, familial abdominal 1, is related to ruptured abdominal aortic aneurysm and aneurysm disease. An important gene associated with Abdominal Aortic Aneurysm is ELN (elastin), and among its related pathways are Metalloproteases in connective tissue degradation and Inhibition of Matrix Metalloproteinases. The drug trimethaphan camsylate and the compounds glucose and lysine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, heart and smooth muscle, and related mouse phenotypes are hematopoietic system and respiratory system.

CDC: An aortic aneurysm (AA) is a ballooning or dilatation of the aorta, the large artery that carries blood from the heart through the chest and abdomen. AAs are classified according to their location; in the chest, it is called a thoracic AA, in the abdomen an abdominal AA (AAA), and across both areas a thoracoabdominal AA.²

Wikipedia: Abdominal aortic aneurysm (also known as AAA, pronounced \"triple-a\") is a localized dilatation...⁴⁴ more...

Aliases & Descriptions:

abdominal aortic aneurysm 6 30 8 aortic aneurysm, familial abdominal 1 6 33 abdominal aortic aneurysm (disorder) 6 aneurysm, abdominal aortic 30

aortic aneurysm, abdominal 43 aortic aneurysm abdominal 32 aortic aneurysm 43

Diseases related to abdominal aortic aneurysm by text searches and GeneDecks gene sharing:

(show top 50)    (show all 994)

id	Related Disease	Score	Top Affiliating Genes
1	ruptured abdominal aortic aneurysm	37.8	XDH, AURKC, IL6, F3, F2, SPG21
2	aneurysm disease	35.4	LPA, MTHFR, MMP1, MMP9, IL1B, FBN1
3	marfan syndrome	33.5	BMP6, MTHFR, MMP14, MMP2, FBLN2, FBN1
4	atherosclerosis	32.3	SELE, CETP, MMP3, ALOX5, ESR1, ELN
5	chronic obstructive pulmonary disease	32.1	XDH, MPO, MMP1, MMP12, MMP8, MMP9
6	thoracic aortic aneurysm	32.0	MMP1, MMP2, FBN1, ELN, TGFBR2
7	aortic disease	31.9	REN, MMP1, MMP9, IL6, FBN1, ELN
8	cutis laxa	31.6	BMP6, CD79A, CD40LG, FBLN2, FBN1, LTBP4
9	aortic aneurysm	31.3	LRP5, REN, RETN, VWF, SELE, SELL
10	heparin-induced thrombocytopenia	31.2	SELE, SERPINC1, SERPINE1, MTHFR, CD79A, CD40LG
11	hernia	30.6	MMP1, MMP13, MMP2, MMP9, FGF2, FBN1
12	arterial occlusive disease	30.6	VWF, SELE, MTHFR, CCL2, F3, CBS
13	intracranial aneurysm	30.0	REN, SERPINE1, VEGFA, LPA, VCAN, MTHFR
14	pulmonary function	27.6	LEP, MPO, IL10, IL4, IL6, IL8
15	polycystic kidney disease	27.0	REN, SELE, VEGFA, LCN2, CD79A, MMP2
16	thrombocytopenia	26.8	VWF, SELE, SELL, SERPINC1, SERPINE1, BMP6
17	hemophilia	26.8	VWF, SERPINC1, MTHFR, CD4, CD40LG, IL10
18	hyperhomocysteinemia	26.6	VWF, SELE, SERPINC1, SERPINE1, LPA, BHMT
19	antiphospholipid syndrome	26.3	VWF, SELE, SERPINC1, SERPINE1, VEGFA, MTHFR
20	cytomegalovirus infection	25.8	VWF, SELE, SELL, BMP6, MTHFR, MPO
21	patent ductus arteriosus	24.7	VEGFA, MTRR, MTHFR, MTR, MTHFD1, CETP
22	hyperlipidemia	24.2	RETN, VWF, SERPINC1, SERPINE1, LPA, LEP
23	pneumonia	23.7	SELE, SELL, SERPINC1, SERPINF2, SERPINE1, NAGLU
24	homocysteine	23.1	REN, RETN, VWF, SELE, SERPINC1, SERPINE1
25	ischemia	22.1	REN, RETN, VWF, SELE, SELL, SERPINC1
26	pulmonary disease	19.9	LRP5, REN, RETN, VWF, SELE, SELL
27	hypoxia	19.3	LRP5, REN, VWF, SELE, SELL, SERPINE1
28	obesity	18.2	LRP5, REN, RETN, VWF, SELE, SELL
29	hypertension	17.7	LRP5, REN, RETN, VWF, SELE, SELL
30	inflammatory bowel disease	17.1	RETN, VWF, SELE, SELL, SERPINC1, SERPINE1
31	refractive error	14.6	MMP1, MMP10, MMP12, MMP13, MMP14, MMP2
32	cleft lip	14.3	BHMT, BHMT2, SDC2, MTRR, MTHFR, MTR
33	stickler syndrome	14.3	SDC2, MTRR, MTHFR, MTR, MTHFD1, MMP1
34	sorsby fundus dystrophy	14.2	MMP3, MMP9, ELN, TIMP1, TIMP3
35	conjunctivochalasis	14.2	MMP1, MMP2, MMP3, MMP9, IL6, IL8
36	orofacial cleft	14.1	BHMT, BHMT2, MTRR, MTHFR, MTR, MTHFD1
37	mayer-rokitansky-kuster-hauser syndrome	14.1	LRP5, MTR, FBN1, APOB, ANXA2, CBS
38	basal cell carcinoma	14.1	BAK1, CD44, ITGB1, MMP1, MMP12, MMP13
39	odontogenic myxoma	14.1	VCAN, BAK1, MMP1, MMP2, MMP9, DCN
40	neural tube defect	14.1	MTRR, MTHFR, MTR, MTHFD1, CBS, SHMT1
41	lacrimal duct obstruction	14.1	SELL, XDH, MMP3, HMOX1, TNFRSF1A, PTGS1
42	chronic ulcer of skin	14.0	MMP1, MMP13, MMP8, FGF2, PDGFB, ELANE
43	purpura fulminans	14.0	SERPINC1, MTHFR, APOH, F5, F3, F2
44	protein c deficiency	14.0	SERPINC1, SERPINF2, SERPINE1, MTHFR, APOH, F5
45	peripheral vertigo	14.0	SERPINC1, APOH, F3, F2, CRP
46	yellow fever	13.9	IL1RN, IL6, CCR5, CCL5, F2, CRP
47	homocysteinemia	13.9	MTRR, MTHFR, MTR, FBN1, F5, CBS
48	connective tissue disease	13.9	BMP6, FBN1, APOH, HSPG2, HSPD1, TNXB
49	catastrophic antiphospholipid syndrome	13.9	SERPINE1, MTHFR, CD40LG, APOH, F5, F3
50	homocysteine plasma level	13.9	SERPINC1, MTRR, MTHFR, MTR, F5, NNMT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 trimethaphan camsylate

MalaCards organs/tissues related to abdominal aortic aneurysm:

²²

MGI Mouse Phenotypes related to abdominal aortic aneurysm:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.1	LCN2, BAK1, AXL, CDH5, GZMB, MIF
2	respiratory system phenotype	MP:0005388	10.4	SELL, FBN1, APOE, CBS, CTSH, COL3A1
3	embryogenesis phenotype	MP:0005380	10.3	LRP5, SERPINC1, T, CDH5, ITGA5, FBN1
4	craniofacial phenotype	MP:0005382	10.2	LRP5, NAGLU, T, CDH5, FBN1, CBS
5	endocrine/exocrine gland phenotype	MP:0005379	9.8	LRP5, SELL, SERPINA5, XDH, CD40LG, IL2
6	integument phenotype	MP:0010771	9.6	XDH, T, CD4, CDH5, CD44, ITGB1
7	immune system phenotype	MP:0005387	9.6	LRP5, REN, VWF, SELL, NAGLU, CMA1
8	nervous system phenotype	MP:0003631	9.2	LRP5, REN, VWF, SERPINC1, NAGLU, VCAN
9	renal/urinary system phenotype	MP:0005367	9.2	REN, NAGLU, BHMT, BAK1, ITGB1, MMP14
10	no phenotypic analysis	MP:0003012	9.0	VEGFA, MTHFR, T, CD79A, CD4, CD44
11	limbs/digits/tail phenotype	MP:0005371	8.9	LRP5, VEGFA, VCAN, LEP, BAK1, MTHFR
12	other phenotype	MP:0005395	8.6	CD40LG, ITGB1, MMP14, IL2, FBN1, APOE
13	liver/biliary system phenotype	MP:0005370	8.4	LRP5, RETN, SERPINC1, VEGFA, BHMT, MGLL
14	normal phenotype	MP:0002873	8.2	LRP5, REN, SELE, VEGFA, VCAN, BAK1
15	growth/size phenotype	MP:0005378	7.7	REN, SELE, SERPINE1, NAGLU, BMP6, BHMT
16	skeleton phenotype	MP:0005390	7.7	NAGLU, VEGFA, VCAN, BMP6, LEP, BAK1
17	reproductive system phenotype	MP:0005389	7.6	REN, SERPINA5, VEGFA, LEP, AURKC, CD59
18	adipose tissue phenotype	MP:0005375	7.2	RETN, SERPINE1, LEP, XDH, IL1R1, IL6
19	digestive/alimentary phenotype	MP:0005381	7.2	VWF, VEGFA, LEP, T, CD4, CD44
20	behavior/neurological phenotype	MP:0005386	7.2	LRP5, REN, SELE, NAGLU, LEP, T
21	tumorigenesis	MP:0002006	6.6	SELL, SERPINE1, BHMT, LEP, CD44, ITGB1
22	mortality/aging	MP:0010768	6.5	LRP5, REN, VWF, SELE, SERPINC1, SERPINE1
23	vision/eye phenotype	MP:0005391	6.0	LRP5, SELE, SERPINC1, NAGLU, VEGFA, LEP
24	muscle phenotype	MP:0005369	4.7	REN, VEGFA, LEP, XDH, MPO, CD44
25	homeostasis/metabolism phenotype	MP:0005376	4.6	LRP5, REN, RETN, VWF, SELE, SELL
26	cellular phenotype	MP:0005384	3.8	LRP5, VWF, SELE, SELL, NAGLU, VEGFA
27	cardiovascular system phenotype	MP:0005385	3.4	LRP5, REN, VWF, SELE, SELL, SERPINC1

Articles related to abdominal aortic aneurysm:

(show top 50)    (show all 291)

id	Title	Authors	Year	Affiliating Genes
1	Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm. (21296538)	Pan J.P.... Lai S.T.	2011	HP
2	Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms. (19932694)	AhnstrAPm J.... DahlbAock B.	2010	APOA1, APOB, APOM
3	Azelnidipine decreases plasma matrix metalloproteinas e-9 levels after endovascular abdominal aortic aneurysm repair. (20103998)	Nakamura E.... Aoyagi S.	2009	MMP9
4	Mediators of neutrophil recruitment in human abdominal aortic aneurysms. (19201759)	Houard X.... Michel J.B.	2009	IL8, CCL5, PF4
5	Possible association between genetic polymorphisms in transforming growth factor beta receptors, serum transforming growth factor beta1 concentration and abdominal aortic aneurysm. (19434696)	Golledge J.... Norman P.E.	2009	TGFBR2
6	Molecular targets and abdominal aortic aneurysms. (19519557)	Nanda S.... Longo S.	2009	TNFRSF11B
7	Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm. (18931513)	Moran C.S.... Golledge J.	2009	PPARG, TNFRSF11B, AGT
8	Can local secretion of prostaglandin E2, thromboxane B2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm? (17992560)	Cheuk B.L.... Cheng S.W.	2008	IL6
9	Inhibition of experimental abdominal aortic aneurysm progression by nifedipine. (18204791)	Tomita N.... Morishita R.	2008	MMP9
10	Elastin degradation within the abdominal aortic aneurysm wall--relationship between intramural pH and adjacent thrombus formation. (19021711)	Wiernicki I.... Gutowski P.	2008	ELN
11	Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm. (17996468)	Smallwood L.... Norman P.E.	2008	IL6
12	Chemokine receptor expression on infiltrating lymphocytes from abdominal aortic aneurysms: role of CXCR4-CXCL12 in lymphoid recruitment. (18281050)	Ocana E.... Rodriguez C.	2008	CXCR4, CXCL12, AAAS
13	Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair. (19238864)	Wilson W.R.... Thompson M.M.	2008	MMP3, MMP2, MMP9
14	Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. (17967974)	Golledge J.... Norman P.E.	2007	LEP, ADIPOQ, RETN
15	Polymorphic analysis of the matrix metalloproteinase-9 gene and susceptibility to sporadic abdominal aortic aneurysm. (17223007)	Armani C.... Balbarini A.	2007	MMP9
16	Elevated tissue plasminogen activator in patients with screening-detected abdominal aortic aneurysm. (17543671)	Wanhainen A.... BjAPrck M.	2007	PLAT
17	The candidate gene approach to susceptibility for abdominal aortic aneurysm: TIMP1, HLA-DR-15, ferritin light chain, and collagen XI-Alpha-1. (17182944)	Tilson M.D.... Ro C.Y.	2006	TIMP1, COL11A1
18	Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study. (16879749)	Ogata T.... Kuivaniemi H.	2006	HLA-DQA1, HLA-DQB1, HLA-DRB1
19	eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm. (16171581)	Fatini C.... Pratesi G.	2005	NOS3
20	Systemic dilation diathesis in patients with abdominal aortic aneurysms: a role for matrix metalloproteinase-9? (15749037)	van Laake L.W.... Schurink G.W.	2005	MMP9
21	Interleukin-1 gene cluster variants and abdominal aortic aneurysms. (16268484)	Marculescu R.... Schillinger M.	2005	IL1B, IL1A, IL1RN
22	Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (15944607)	Ogata T.... Kuivaniemi H.	2005	MMP3, MMP2, TGFB1
23	Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms. (16115023)	Verschuren L.... Kleemann R.	2005	MIF
24	Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (16082623)	Eriksson P.... Powell J.T.	2005	MMP3, MMP2, SERPINE1
25	The expression of platelet-derived growth factor and connective tissue growth factor in different types of abdominal aortic aneurysms. (15956925)	Kanazawa S.... Kikuchi K.	2005	PDGFB, CTGF
26	Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells. (15509527)	Krettek A.... Libby P.	2004	CD44
27	Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. (14681642)	Jones G.T.... van Rij A.M.	2003	MMP9
28	Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? (14582543)	PA/der P.... Zilmer M.	2003	SOD1, CAT
29	Systemic levels of cotinine and elastase, but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms. (14512006)	Lindholt J.S.... Henneberg E.W.	2003	ELANE
30	Response of plasma matrix metalloproteinase-9 to conventional abdominal aortic aneurysm repair or endovascular exclusion: implications for endoleak. (12021707)	Lorelli D.R.... Towne J.B.	2002	MMP9
31	Familial abdominal aortic aneurysm: a systematic review of a genetic background. (12389231)	van Vlijmen-van Keulen C.J.... Rauwerda J.A.	2002	ELN, FBN1
32	Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. (11807372)	Unno N.... Nakamura S.	2002	PLA2G7
33	Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V(0). (11166769)	Theocharis A.D.... Karamanos N.K.	2001	VCAN
34	The relation between Chlamydia pneumoniae infection and abdominal aortic aneurysm (11899845)	Wolski A.... Michalak J.	2001	CD79A
35	Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. (11342474)	Jones K.G.... Powell J.T.	2001	IL6
36	The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms. (11496285)	Nollendorfs A.... Baxter B.T.	2001	MMP2, MMP14
37	Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array. (11436088)	Tung W.S.... Thompson R.W.	2001	MNDA
38	Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms. (10957667)	Crowther M.... Thompson M.M.	2000	MMP2
39	Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. (10441523)	Mao D.... Thompson R.W.	1999	MMP13
40	Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms. (10393680)	Walton L.J.... Powell J.T.	1999	ELN
41	MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial. (10415728)	Thompson R.W.... Baxter B.T.	1999	MMP2, MMP9
42	Reduced capacity to inhibit elastase in abdominal aortic aneurysm. (10068521)	Rao S.K.... Cohen J.R.	1999	ELN, ELANE
43	The role of type III collagen in the development of f amilial abdominal aortic aneurysms. (10388642)	van Keulen C.J.... Rauwerda J.A.	1999	COL3A1
44	Treatment for abdominal aortic aneurysm in a patient with hemophilia A: a case report and review of the literature. (9152326)	Kobayashi M.... Nimura Y.	1997	F3
45	Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem. (8889378)	Thompson R.W.	1996	ELN
46	Matrix metalloproteinases in abdominal aortic aneurysm: characterization, purification, and their possible sources. (7956205)	Newman K.M.... Tilson M.D.	1994	ELN
47	Role of the neutrophil in abdominal aortic aneurysm development. (8076062)	Cohen J.R.... Wise L.	1993	ELANE
48	Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms. (1777436)	Cohen J.R.... Wise L.	1991	ELANE
49	The calcium messenger system and the kinetics of elas tase release from human neutrophils in patients with abdominal aortic aneurysms . (2175637)	Cohen J.R.... Wise L.	1990	ELANE
50	Familial abdominal aortic aneurysms. (3418662)	Loosemore T.M.... Dormandy J.A.	1988	AAA1

Genes related to abdominal aortic aneurysm according to GeneCards:

(show top 50)    (show all 209)

id	Symbol	Description	Score	GeneCards Section Context
1	ELN	elastin	11.0	Publications
2	AURKC	aurora kinase C	11.0
3	SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	11.0
4	AAAS	achalasia, adrenocortical insufficiency, alacrimia	11.0	Publications
5	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
6	HELLS	helicase, lymphoid-specific	11.0
7	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
8	F2	coagulation factor II (thrombin)	11.0	Publications
9	XDH	xanthine dehydrogenase	11.0	Publications
10	AAA1	aortic aneurysm, familial abdominal 1	11.0	Publications
11	HOXA4	homeobox A4	11.0	Publications
12	APOM	apolipoprotein M	11.0	Publications
13	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
14	MNDA	myeloid cell nuclear differentiation antigen	11.0	Publications
15	BHMT2	betaine--homocysteine S-methyltransferase 2	11.0	Publications
16	PROK2	prokineticin 2	11.0	Publications
17	NNMT	nicotinamide N-methyltransferase	11.0	Publications
18	IGKC	immunoglobulin kappa constant	11.0	Publications
19	TNFSF12	tumor necrosis factor (ligand) superfamily, member 12	11.0	Publications
20	LTBP3	latent transforming growth factor beta binding protein 3	11.0	Publications
21	CTSH	cathepsin H	11.0	Publications
22	LTBP4	latent transforming growth factor beta binding protein 4	11.0	Publications
23	PLA2G10	phospholipase A2, group X	11.0	Publications
24	PGRMC1	progesterone receptor membrane component 1	11.0
25	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
26	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
27	SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	11.0	Publications
28	SERBP1	SERPINE1 mRNA binding protein 1	11.0	Publications
29	ENOSF1	enolase superfamily member 1	11.0	Publications
30	KLK1	kallikrein 1	11.0	Publications
31	T	T, brachyury homolog (mouse)	11.0	Publications
32	C17orf85	chromosome 17 open reading frame 85	11.0
33	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications
34	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Functions, Publications
35	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
36	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
37	ELANE	elastase, neutrophil expressed	11.0	Publications
38	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
39	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
40	LTB4R	leukotriene B4 receptor	11.0	Publications
41	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
42	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
43	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.0	Publications
44	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
45	COL3A1	collagen, type III, alpha 1	11.0	Publications
46	PRDX1	peroxiredoxin 1	11.0	Publications
47	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
48	AHCY	adenosylhomocysteinase	11.0	Publications
49	TCN2	transcobalamin II	11.0	Publications
50	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications

Pathways related to abdominal aortic aneurysm according to GeneDecks:

(show top 50)    (show all 148)

id	Pathway	Score	Top Affiliating Genes
1	Metalloproteases in connective tissue degradation10	11.2	CMA1, MMP1, MMP10, MMP12, MMP13, MMP14
2	Inhibition of Matrix Metalloproteinases36	11.1	SDC2, MMP1, MMP10, MMP12, MMP13, MMP14
3	Activation of Matrix Metalloproteinases38	10.9	CMA1, MMP1, MMP10, MMP13, MMP14, MMP2
4	Cell adhesion_Cell-matrix glycoconjugates41	10.8	SELE, SELL, VCAN, CD44, ITGB1, MMP1
5	Transendothelial Migration of Leukocytes36	10.8	SDC2, CDH5, ITGA5, ITGB1, MMP1, MMP10
6	Cell adhesion Cell-matrix glycoconjugates10	10.7	SELE, SELL, VCAN, CD44, ITGB1, MMP3
7	Cell adhesion ECM remodeling10	10.7	SERPINE1, VCAN, SDC2, CD44, ITGA5, ITGB1
8	UPA-UPAR Pathway36	10.7	SERPINE1, ITGA5, ITGB1, MMP1, MMP10, MMP12
9	RAR-Gamma-RXR-Alpha Degradation36	10.7	IL2, CCL3, CCL5, PF4, TGFB3, OSM
10	Blood Coagulation Signaling Pathways37	10.4	VWF, SERPINC1, SERPINA5, SERPINF2, SERPINE1, GP1BA
11	Graft-versus-host disease20	10.1	IL1A, IL2, HLA-A, HLA-B, HLA-DQA1, HLA-DRB3
12	Intestinal immune network for IgA production20	9.9	CD40LG, CD40, IL10, IL2, IL4, IL6
13	Hematopoietic cell lineage20	9.8	CD59, CD4, CD44, ITGA5, IL1A, IL1B
14	Glioma Invasiveness36	9.8	BMP6, CD44, ITGA5, ITGB1, FGF2, PLAU
15	PTEN Pathway36	9.8	FLT1, FGF2, IL2, IL2RA, FBN1, MAPK1
16	Angiogenesis3	9.8	REN, CDH5, ITGA5, ITGB1, MMP2, MMP9
17	Akt Signaling36	9.7	AXL, CD4, IL10, IL2, IL2RA, IL4
18	Malaria20	9.5	SELE, SDC2, CD40LG, CD40, IL10, IL1B
19	PPAR Pathway36	9.4	ITGA5, ITGB1, FLT1, FGF2, IL2, IL2RA
20	IL-6 Pathway36	9.4	BMP6, IL10, IL4, IL8, MAPK1, CCL2
21	DHA Signaling36	9.4	BMP6, FLT1, FGF2, IL1B, IL2, IL2RA
22	Mitochondrial Apoptosis36	9.3	BMP6, BAK1, FLT1, FGF2, IL2, IL2RA
23	Autoimmune thyroid disease20	9.3	CD40LG, CD40, GZMB, IL10, IL2, IL4
24	Telomerase Components in Cell Signaling36	9.3	BMP6, FLT1, FGF2, IL2, CTGF, PDGFB
25	Cellular Apoptosis Pathway36	9.2	BMP6, BAK1, FLT1, FGF2, IL2, IL2RA
26	Pancreatic Adenocarcinoma36	9.2	BMP6, AXL, MMP1, MMP10, MMP12, MMP13
27	Apoptotic Pathways in Synovial Fibroblasts36	9.2	BMP6, FLT1, FGF2, IL2, IL2RA, IL6
28	NF-KappaB (p50-p65) Pathway36	9.1	BMP6, FLT1, FGF2, IL1A, IL1B, IL1R1
29	NF-KappaB Family Pathway36	9.1	BMP6, FLT1, FGF2, IL1A, IL1B, IL1R1
30	Molecular Mechanisms of Cancer36	9.1	LRP5, BMP6, BAK1, AURKC, CD4, ITGA5
31	Rheumatoid arthritis20	9.0	VEGFA, MMP1, MMP3, FLT1, IL1A, IL1B
32	Toxoplasmosis20	9.0	CD40LG, CD40, ITGB1, IL10, MAPK1, CCR5
33	Type I diabetes mellitus20	8.9	GZMB, IL1A, IL1B, IL2, IFNG, HSPD1
34	NFAT in Immune Response36	8.8	BMP6, AXL, CD79A, CD4, FLT1, FGF2
35	PEDF Induced Signaling36	8.8	BMP6, IL10, IL1A, IL1B, IL2, IL4
36	Phospholipase-C Pathway36	8.8	BMP6, CD79A, ITGA5, ITGB1, FLT1, FGF2
37	Chagas disease (American trypanosomiasis)20	8.8	SERPINE1, IL10, IL1B, IL2, IL6, IL8
38	p70S6K Signaling36	8.8	BMP6, FLT1, FGF2, IL2, IL2RA, IL4
39	PAK Pathway36	8.7	BMP6, FLT1, FGF2, IL10, IL1A, IL1B
40	Rho Family GTPases36	8.6	BMP6, AXL, CDH5, ITGA5, ITGB1, FLT1
41	THC Differentiation Pathway36	8.6	IL10, IL2, IL2RA, IL4, IFNG, HLA-DQA1
42	Tec Kinases Signaling36	8.5	BMP6, CD4, ITGA5, ITGB1, FGF2, IL10
43	MIF Mediated Glucocorticoid Regulation36	8.5	BMP6, MIF, IL10, IL1A, IL1B, IL2
44	MIF Regulation of Innate Immune Cells36	8.5	BMP6, MIF, IL10, IL1A, IL1B, IL2
45	ERK Signaling36	8.4	BMP6, AXL, ITGA5, ITGB1, FLT1, IL10
46	p38 Signaling36	8.3	BMP6, AXL, CD4, FLT1, FGF2, IL10
47	STAT3 Pathway36	8.2	BMP6, CD4, IL10, IL1A, IL1B, IL1R1
48	TGF-Beta Pathway36	8.2	BMP6, CD4, FLT1, FGF2, IL10, IL1A
49	MAPK Family Pathway36	8.0	BMP6, CD4, FLT1, FGF2, IL10, IL1A
50	JAK-STAT Pathway36	7.5	BMP6, AXL, CD4, FLT1, FGF2, IL10

Compounds related to abdominal aortic aneurysm according to GeneDecks:

(show top 50)    (show all 467)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.1	VCAN, BAK1, CDH5, GZMB, MIF, GP1BA
2	lysine32	11.0	SERPINF2, FBN1, ANXA2, CCL3, TNFRSF11B, CTSG
3	hydroxamate32	10.5	MMP1, MMP12, MMP13, MMP14, MMP2, MMP3
4	chymostatin32	10.4	REN, CMA1, APOA1, CTSG, EDN1, ACE
5	doxycycline32 9 9	12.3	CD79A, CD40LG, MMP1, MMP13, MMP2, MMP3
6	egcg32	10.0	IL1A, CCL5, HSPG2, CAT, PTGS1, ELANE
7	gabexate mesilate32	9.8	SELE, SERPINC1, XDH, MMP9, IL10, IL6
8	calcium32 9 18 9	12.7	LRP5, REN, RETN, VWF, SERPINF2, NAGLU
9	biotin32 9 18 9	12.7	VWF, SELL, CD79A, CD40LG, CD40, CD44
10	fluvastatin32 34 9 9	12.6	VWF, SERPINE1, CETP, CD40, MMP1, MMP9
11	valsartan32 42 9 9	12.6	REN, SERPINE1, CCL2, ALB, PPARG, CRP
12	ramipril32 9 9	11.6	REN, SERPINE1, CD79A, ALB, HMGCR, CRP
13	wortmannin32 42	10.4	LEP, AXL, CD40, ITGB1, MMP14, MMP2
14	vitamin-e32	9.4	NAGLU, LPA, CD40, MMP12, IL1R1, IL1RN
15	ns 39832 42	10.4	MMP1, FGF2, IL1A, IL1B, IL8, MAPK1
16	pravastatin32 34 9 18 9	13.3	SELE, SERPINE1, LPA, CETP, IL6, APOA1
17	homocysteine32 18	10.2	RETN, VWF, SELE, SERPINC1, SERPINE1, NAGLU
18	oxygen32 18	10.2	SERPINF2, NAGLU, BAK1, MTR, MPO, CD59
19	ribonucleic acid32	9.1	BMP6, CDH5, CD40, MMP1, MMP13, MMP14
20	calcitriol32 42 9 18 9	13.0	REN, BMP6, BAK1, CD44, ITGB1, MMP14
21	warfarin32 34 9 18 9	13.0	VWF, SERPINC1, SERPINA5, LPA, MTHFR, AXL
22	heparin32 9 18 9	11.9	VWF, SERPINA5, SERPINF2, SERPINE1, LPA, VCAN
23	vitamin b1232	8.8	VWF, LPA, BHMT, MTRR, MTHFR, MTR
24	curcumin32	8.5	VEGFA, BAK1, MMP1, MMP13, MMP14, MMP2
25	matrigel32	8.4	VWF, SELE, SERPINE1, VEGFA, BMP6, CDH5
26	norepinephrine32 9 18 9	11.3	REN, RETN, VWF, SELE, SELL, BMP6
27	neopterin32	8.2	NAGLU, LCN2, CD79A, CD4, CD40LG, CD40
28	troglitazone32 42 9 9	11.1	SELE, SERPINE1, BMP6, LEP, BAK1, MMP1
29	triptolide32	8.1	VEGFA, CD40, MMP3, IL1B, IL2, IL6
30	resveratrol32 9 18 9	10.9	VEGFA, BAK1, XDH, MMP2, MMP9, MAPK1
31	gm-csf32	7.9	VEGFA, BMP6, IL10, IL1A, IL1B, IL2
32	sodium dodecylsulfate32	7.8	VWF, SERPINF2, SERPINE1, LPA, BMP6, CETP
33	doxorubicin32 34 9 9	10.8	SELE, BMP6, BAK1, CD40LG, CD40, CD44
34	rantes32	7.7	SELE, SELL, BMP6, CD4, CD40LG, CD40
35	nitric oxide32 9 18 9	10.6	REN, RETN, SELE, NAGLU, LPA, BMP6
36	arginine32	7.6	REN, VWF, SERPINC1, SERPINF2, LPA, LEP
37	hydrocortisone32 9 9	9.6	REN, BMP6, CDH5, CD40, MMP1, MMP2
38	thyroxine32 18	8.5	REN, RETN, VWF, SERPINF2, LPA, LEP
39	estrogen32	7.5	LRP5, RETN, VWF, SERPINC1, SERPINE1, LPA
40	acetylcholine32 9 18 9	10.4	VWF, BMP6, LEP, MPO, CD79A, CD40LG
41	lipid32	7.4	LRP5, RETN, SELE, SERPINF2, SERPINE1, NAGLU
42	vitamin d32	7.3	LRP5, SERPINE1, NAGLU, BMP6, MTHFR, CD79A
43	paclitaxel32 34 9 9	10.2	VEGFA, BMP6, BAK1, CD40, CD44, MMP1
44	creatinine32	7.2	REN, RETN, VWF, SELE, SELL, SERPINC1
45	15-deoxy-delta-12,14-prostaglandin j232	6.8	SERPINE1, VEGFA, BMP6, FGF2, IL10, IL1B
46	simvastatin32 34 42 9 18 9	11.1	VWF, SELE, SELL, SERPINE1, VEGFA, LPA
47	genistein32 9 18 9	8.8	SELE, SELL, SERPINE1, VEGFA, CD4, CD40LG
48	cyclosporin a32 42	6.5	VWF, NAGLU, BMP6, LEP, MTHFR, CETP
49	indomethacin32 9 9	6.3	REN, SELL, BMP6, LEP, BAK1, MPO
50	dexamethasone32 42 34 9 9	7.9	REN, RETN, VWF, SELL, SERPINC1, SERPINE1

Cellular components related to abdominal aortic aneurysm according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	10.7	TGFB1, VCAN, VEGFA, VWF, MMP1, MMP10
2	MHC class II protein complex	GO:042613	10.4	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
4	ER to Golgi transport vesicle membrane	GO:012507	10.1	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
5	extracellular matrix	GO:031012	10.0	CTSG, TNXB, TNC, HSPG2, F3, ANXA2
6	cell surface	GO:009986	10.0	CXCR4, IL1A, MIF, ITGB1, CD44, CD59
7	clathrin-coated endocytic vesicle membrane	GO:030669	9.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
8	platelet alpha granule lumen	GO:031093	9.8	HGF, TGFB3, TGFB1, TIMP1, PDGFB, PF4
9	integral to plasma membrane	GO:005887	9.4	TNFSF12, TNFRSF1A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1
10	external side of plasma membrane	GO:009897	8.5	CXCR4, CXCL12, TGFBR2, ACE, TNF, HLA-DRB5
11	extracellular region	GO:005576	7.2	LTBP3, TNFRSF1A, TNFRSF11B, TNC, ESR2, HPSE
12	plasma membrane	GO:005886	6.5	CTGF, CTSG, PLAU, NOS3, LTB4R, ABCC6
13	extracellular space	GO:005615	5.3	HGF, ADIPOQ, ADM, PECAM1, NPPB, PON1

Biological processes related to abdominal aortic aneurysm according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:022617	11.3	CTSG, MMP9, MMP8, MMP3, MMP2, MMP14
2	extracellular matrix organization	GO:030198	11.3	MMP3, MMP2, MMP14, MMP13, MMP10, MMP1
3	proteolysis	GO:006508	11.2	CTSH, CTSG, CTSL1, PLAT, PLAU, LTF
4	collagen catabolic process	GO:030574	11.0	MMP9, MMP8, MMP3, MMP2, MMP13, MMP10
5	blood vessel remodeling	GO:001974	10.8	TGM2, AGT, ELN, NOS3, CBS, AXL
6	aging	GO:007568	10.7	TIMP1, TIMP3, TGFB1, TGFB3, DCN, ADM
7	positive regulation of inflammatory response	GO:050729	10.6	CX3CL1, TGM2, AGTR1, AGT, PLA2G7, TNFRSF1A
8	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.6	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
9	response to cholesterol	GO:070723	10.5	TGFBR2, TGFBR1, TGFB1, CCL5, CCL3, CCR5
10	response to mechanical stimulus	GO:009612	10.5	CXCL12, DCN, TIMP3, NOS3, TNF, ETS1
11	protein tetramerization	GO:051262	10.4	SHMT1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HMGCR
12	B cell proliferation	GO:042100	10.4	CD40LG, CD40, IL10, HSPD1, PRKCD, CD79A
13	positive regulation of cellular protein metabolic process	GO:032270	10.4	ADIPOQ, CSF1, TGFB1, AGTR1, AGT, PLA2G10
14	monocyte chemotaxis	GO:002548	10.4	PDGFB, CCL5, CCL3, CCL2, IL6, FLT1
15	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.4	PDGFB, AGT, OSM, ADIPOQ, HGF, IL6
16	positive regulation of cell migration	GO:030335	10.4	CTSH, PDGFB, EDN1, TGFB1, CSF1, ADAM17
17	organ regeneration	GO:031100	10.3	HGF, ADM, CXCL12, TGFB1, NNMT, PPARG
18	low-density lipoprotein particle remodeling	GO:034374	10.3	AGTR1, AGT, PLA2G7, APOB, MPO, CETP
19	angiogenesis	GO:001525	10.2	TNFSF12, CTGF, NOS3, COL4A2, HIF1A, PROK2
20	positive regulation of smooth muscle cell proliferation	GO:048661	10.1	CX3CL1, TGM2, HIF1A, ELANE, EDN1, PDGFB
21	response to lipopolysaccharide	GO:032496	10.1	EDN1, ELANE, THBD, DCN, ADM, ADAM17
22	positive regulation of angiogenesis	GO:045766	10.1	ADM, CX3CR1, CX3CL1, HIF1A, NOS3, SERPINE1
23	chemotaxis	GO:006935	10.0	PROK2, CX3CR1, CXCL1, CXCL12, CXCL5, CXCR2
24	positive regulation of MAP kinase activity	GO:043406	10.0	CD40, FLT1, TNF, PDGFB, EDN1, ELANE
25	positive regulation of cell proliferation	GO:008284	10.0	EDN1, TIMP1, TGFB1, TGFBR1, TGFBR2, OSM
26	neutrophil chemotaxis	GO:030593	10.0	CXCR2, CX3CL1, EDN1, SPP1, IFNG, CCL3
27	response to glucocorticoid stimulus	GO:051384	10.0	TNF, PTGS2, PLAT, ADM, ADIPOQ, CCL5
28	positive regulation of cell division	GO:051781	9.9	OSM, TGFB3, TGFB1, PDGFB, CAT, IL1B
29	negative regulation of cell proliferation	GO:008285	9.8	ADM, CXCL1, OSM, TGFB3, TGFB1, TIMP2
30	cell surface receptor signaling pathway	GO:007166	9.8	IFNG, F2, COL4A3, EDN1, CXCR2, NPPB
31	cytokine-mediated signaling pathway	GO:019221	9.8	HLA-DRB3, HLA-DRB4, HLA-DRB5, TNFRSF1A, PF4, EGR1
32	female pregnancy	GO:007565	9.7	ADM, NPPA, TGFB3, TGFB1, THBD, ETS1
33	interferon-gamma-mediated signaling pathway	GO:060333	9.7	HLA-A, IFNG, CD44, HLA-B, HLA-DQA1, HLA-DQB1
34	negative regulation of blood coagulation	GO:030195	9.6	APOE, APOH, EDN1, THBD, SERPINE1, PROC
35	platelet degranulation	GO:002576	9.6	TIMP1, TGFB1, TGFB3, SOD1, PECAM1, HGF
36	platelet activation	GO:030168	9.4	GP1BA, MAPK1, APOA1, IL6, MGLL, CD40
37	cellular response to lipopolysaccharide	GO:071222	9.4	CX3CR1, NOS2, IFNG, CCR5, CCL2, IL8
38	positive regulation of endothelial cell proliferation	GO:001938	9.4	CXCL12, HIF1A, PDGFB, TNFSF12, F3, CCL2
39	negative regulation of apoptotic process	GO:043066	9.4	TNF, CTSH, PF4, TIMP1, PROC, CX3CL1
40	response to estradiol stimulus	GO:032355	9.3	TGFB1, PDGFB, NOS3, CTGF, PTGS2, ESR1
41	lipoprotein metabolic process	GO:042157	9.3	HSPG2, LPA, CETP, APOA1, APOB, APOE
42	negative regulation of gene expression	GO:010629	9.3	PGR, NOS2, TNFRSF1A, TNF, ESR1, CCL3
43	small molecule metabolic process	GO:044281	9.0	CTGF, PTGS1, PTGS2, HMGCR, HMOX1, HPSE
44	regulation of blood pressure	GO:008217	8.9	NPPB, NPPA, SOD1, ACE, COL1A2, NOS3
45	anti-apoptosis	GO:006916	8.9	HMOX1, TNF, NOS3, PROK2, SOD1, ADAM17
46	immune response	GO:006955	8.7	CXCL5, CXCL12, CXCL1, CX3CL1, IL8, IL4
47	inflammatory response	GO:006954	8.7	PROK2, IL10, MGLL, MIF, CD40, CD40LG
48	blood coagulation	GO:007596	8.6	HGF, PECAM1, SOD1, PROC, PRKCD, TGFB3
49	response to drug	GO:042493	8.4	NOS3, PPARG, PTGS2, TNFRSF11B, TNF, IFNG
50	response to hypoxia	GO:001666	8.4	ADIPOQ, ADAM17, ADM, ETS1, CAT, CCL2

Molecular functions related to abdominal aortic aneurysm according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:004252	10.9	PLAU, LTF, KLK1, ELANE, PROC, HGF
2	protease binding	GO:002020	10.6	F3, TNF, TNFRSF1A, ELANE, CST3, IL1R1
3	chemokine activity	GO:008009	10.4	CXCL5, CXCL12, CXCL1, CX3CL1, PF4, CCL5
4	extracellular matrix binding	GO:050840	10.4	ELN, COL11A1, SPP1, FBLN2, VEGFA, DCN
5	integrin binding	GO:005178	10.3	ADAM17, TIMP2, LTBP4, COL4A3, COL3A1, CTGF
6	extracellular matrix structural constituent	GO:005201	10.1	ELN, COL4A3, COL11A1, COL4A2, COL3A1, COL1A2
7	heparin binding	GO:008201	9.4	ELANE, FGF2, MPO, LPA, VEGFA, SERPINA5
8	receptor binding	GO:005102	9.1	NOS2, CX3CL1, CXCL1, CXCL12, NPPA, NPPB
9	growth factor activity	GO:008083	8.6	HGF, CSF1, CXCL12, CXCL1, IL1B, IL10
10	cytokine activity	GO:005125	7.9	SPP1, FGF2, MIF, CD40LG, BMP6, VEGFA
11	protein homodimerization activity	GO:042803	7.7	PTGS2, CRP, NOS2, PDGFB, SHMT1, TGFB1
12	enzyme binding	GO:019899	7.6	PTGS2, PPARG, HIF1A, TGFB1, PRKCD, PGR
13	protein binding	GO:005515	5.1	HGF, ADIPOQ, ADAM17, ADM, PECAM1, PGRMC1