MCID: ABD010
MIFTS: 29

Abdominal Wall Defect malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Abdominal Wall Defect

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 An abdominal wall defect is an opening in the abdomen through which various abdominal organs can protrude. This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. There are two main types of abdominal wall defects: omphalocele and gastroschisis. Omphalocele is an opening in the center of the abdominal wall where the umbilical cord meets the abdomen. Organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord and are covered by the same protective membrane that covers the umbilical cord. Gastroschisis is a defect in the abdominal wall, usually to the right of the umbilical cord, through which the large and small intestines protrude (although other organs may sometimes bulge out). There is no membrane covering the exposed organs in gastroschisis.

MalaCards: Abdominal Wall Defect, also known as thyroid hormone plasma membrane transport defect, is related to gastroschisis and omphalocele. An important gene associated with Abdominal Wall Defect is CDKN1C (cyclin-dependent kinase inhibitor 1C (p57, Kip2)). The compound irinotecan have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and thyroid, and related mouse phenotype mortality/aging.

Wikipedia:63 Abdominal Wall defects are a type of congenital defect that allows the stomach,the intestines, or other... more...

Aliases & Classifications for Abdominal Wall Defect

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21Genetics Home Reference, 60UMLS, 25ICD10
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Related Diseases for Abdominal Wall Defect

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17GeneCards, 18GeneDecks
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Diseases related to Abdominal Wall Defect via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1gastroschisis30.9ACHE, AFP
2omphalocele30.5ACHE, CDKN1C, AFP
3beckwith-wiedemann syndrome30.3CDKN1C, NSD1
4spina bifida29.9AFP
5thyroid hormone plasma membrane transport defect10.6
6patent foramen ovale10.4
7glanzmann's thrombasthenia10.4
8takayasu's arteritis10.4
9atrioventricular septal defect10.4
10atrial heart septal defect10.4
11congenital heart defect10.4
12urea cycle disorder10.4
13hereditary folate malabsorption10.4
14zap70-related severe combined immunodeficiency10.4
15acro-pectoro-renal field defect10.4
16ankle defects short stature10.4
17axial mesodermal dysplasia spectrum10.4
18branchial arch defects10.4
19cardioskeletal syndrome kuwaiti type10.4
20sacral defect with anterior meningocele10.4
21caudal regression syndrome10.4
22chylomicron retention disease10.4
23x-linked creatine deficiency10.4
24cystinosis, ocular nonnephropathic10.4
25hmg coa lyase deficiency10.4
26imerslund-grasbeck syndrome10.4
27defective apolipoprotein b-10010.4
28diaphragmatic hernia upper limb defects10.4
29peroxisome disorders10.4
30heart defect, tongue hamartoma and polysyndactyly10.4
31hermansky pudlak syndrome 210.4
32heterotaxy10.4
33red cell phospholipid defect with hemolysis10.4
34hyperthermia induced defects10.4
35lateral body wall defect10.4
36laterality defects dominant10.4
37limb reduction defect10.4
38overgrowth radial ray defect arthrogryposis10.4
39paraomphalocele10.4
40reductional transverse limb defects10.4
41renal agenesis meningomyelocele mullerian defect10.4
42trigonomacrocephaly tibial defect polydactyly10.4
43thyroid hormonogenesis defect i10.4
44combined oxidative phosphorylation deficiency 210.4
45combined oxidative phosphorylation deficiency 510.4
46combined oxidative phosphorylation deficiency 410.4
47combined oxidative phosphorylation deficiency 710.4
48combined oxidative phosphorylation deficiency 810.4
49combined oxidative phosphorylation deficiency 1010.4
50critical congenital heart disease10.4

Graphical network of the top 20 diseases related to Abdominal Wall Defect:



Diseases related to abdominal wall defect

Clinical Features for Abdominal Wall Defect

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Drugs & Therapeutics for Abdominal Wall Defect

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Abdominal Wall Defect

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Anatomical Context for Abdominal Wall Defect

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32MalaCards
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MalaCards organs/tissues related to Abdominal Wall Defect:

32
Small intestine, Liver, Thyroid

Animal Models for Abdominal Wall Defect or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Abdominal Wall Defect:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5ACHE, RTL1, CDKN1C, AFP, NSD1

Publications for Abdominal Wall Defect

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Genetic Variations for Abdominal Wall Defect

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Expression for genes affiliated with Abdominal Wall Defect

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Abdominal Wall Defect

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Pathways for genes affiliated with Abdominal Wall Defect

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Compounds for genes affiliated with Abdominal Wall Defect

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Abdominal Wall Defect according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1irinotecan44 49 1111.3ACHE, AFP

GO Terms for genes affiliated with Abdominal Wall Defect

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Products for genes affiliated with Abdominal Wall Defect

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Abdominal Wall Defect

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet