MCID: ABD010
MIFTS: 38

Abdominal Wall Defect malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Abdominal Wall Defect

Summaries for Abdominal Wall Defect

Genetics Home Reference : 25 An abdominal wall defect is an opening in the abdomen through which various abdominal organs can protrude. This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. There are two main types of abdominal wall defects: omphalocele and gastroschisis. Omphalocele is an opening in the center of the abdominal wall where the umbilical cord meets the abdomen. Organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord and are covered by the same protective membrane that covers the umbilical cord. Gastroschisis is a defect in the abdominal wall, usually to the right of the umbilical cord, through which the large and small intestines protrude (although other organs may sometimes bulge out). There is no membrane covering the exposed organs in gastroschisis.

MalaCards based summary : Abdominal Wall Defect, also known as gastroschisis, is related to gastroschisis abdominal wall defects, included and gastroschisis. An important gene associated with Abdominal Wall Defect is GJB2 (Gap Junction Protein Beta 2). The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and skin.

Wikipedia : 71 Abdominal wall defects are a type of congenital defect that allows the stomach, the intestines, or other... more...

Related Diseases for Abdominal Wall Defect

Diseases related to Abdominal Wall Defect via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
id Related Disease Score Top Affiliating Genes
1 gastroschisis abdominal wall defects, included 12.1
2 gastroschisis 11.3
3 omphalocele 11.2
4 shprintzen-goldberg syndrome 11.1
5 beckwith-wiedemann syndrome 10.9
6 amniotic band syndrome 10.8
7 paraomphalocele 10.8
8 fryns microphthalmia syndrome 10.8
9 enterocele 10.1
10 desmoid tumor 9.8
11 cloacal exstrophy 9.8
12 neural tube defects 9.7
13 prune belly syndrome 9.7
14 squamous cell carcinoma 9.7
15 gastroesophageal reflux 9.7
16 congenital diaphragmatic hernia 9.7
17 peritonitis 9.7
18 bladder exstrophy 9.7
19 imperforate anus 9.6
20 necrotizing fasciitis 9.6
21 short bowel syndrome 9.6
22 sarcoma 9.6
23 limb-body wall complex 9.6
24 ichthyosis 9.6
25 soft tissue sarcoma 9.6
26 focal dermal hypoplasia 9.6
27 histiocytoma 9.6
28 fibrous histiocytoma 9.6
29 muscular atrophy 9.6
30 inguinal hernia 9.6
31 eec syndrome 9.6
32 actinomycosis 9.6
33 duodenitis 9.6
34 fasciitis 9.6
35 hemorrhoid 9.5
36 intestinal obstruction 9.5

Graphical network of the top 20 diseases related to Abdominal Wall Defect:



Diseases related to Abdominal Wall Defect

Symptoms & Phenotypes for Abdominal Wall Defect

Drugs & Therapeutics for Abdominal Wall Defect

Drugs for Abdominal Wall Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 206)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
3
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
4
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
5
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
6
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
7
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
8
Ropivacaine Approved Phase 4,Phase 2 84057-95-4 71273 175805
9
Levobupivacaine Approved Phase 4,Phase 2 27262-47-1 92253
10
Clonidine Approved Phase 4,Phase 3,Phase 2 4205-90-7 2803
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
12
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
13
Ibuprofen Approved Phase 4 15687-27-1 3672
14
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
15
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
16
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
19
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
20
Tizanidine Approved Phase 4 51322-75-9 5487
21
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
22
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
23
Prilocaine Approved Phase 4 721-50-6 4906
24
Chloroprocaine Approved Phase 4 133-16-4 8612
25
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
26
Ondansetron Approved Phase 4,Phase 2,Phase 3 99614-02-5 4595
27
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3 60142-96-3 3446
28
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
29
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
30
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
31
Meperidine Approved Phase 4 57-42-1 4058
32
Nicotine Approved Phase 4 54-11-5 942 89594
33
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
34 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
35 Analgesics Phase 4,Phase 3,Phase 2,Early Phase 1
36 calcium channel blockers Phase 4,Phase 3,Phase 2
37 Adjuvants, Anesthesia Phase 4,Phase 3
38 Narcotics Phase 4,Phase 3
39 GABA Agents Phase 4,Phase 3
40 Sodium Channel Blockers Phase 4,Phase 3
41 Coagulants Phase 4,Phase 1
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Cyclooxygenase Inhibitors Phase 4,Phase 3
44 Hemostatics Phase 4,Phase 1
45 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
46 Analgesics, Opioid Phase 4,Phase 3
47 Tranquilizing Agents Phase 4,Phase 3,Phase 2
48 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Diuretics, Potassium Sparing Phase 4,Phase 3
50 Anesthetics, General Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 545)
id Name Status NCT ID Phase
1 Transvaginal Cholecystectomy Versus Laparoscopic Cholecystectomy in Patients With Biliary Colic Unknown status NCT00963950 Phase 4
2 Rebound Hernia Repair Device Mesh Trial Unknown status NCT00968773 Phase 4
3 Study of Surgical Mesh for Inguinal Hernia Repair Unknown status NCT00924755 Phase 4
4 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
5 Absorbable Versus Permanent Mesh Fixation Trial in Laparoscopic Midline Ventral Hernia Repair Unknown status NCT01109771 Phase 4
6 Ultrasound-guided Ilioinguinal-iliohypogastric Block for Inguinal Hernia Repair Unknown status NCT01326039 Phase 4
7 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4
8 Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair Unknown status NCT00625053 Phase 4
9 A Prospective, Observational Study Utilizing Phasix™ Mesh During Ventral and Incisional Hernia Repair Surgery Unknown status NCT01863030 Phase 4
10 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
11 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
12 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
13 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
14 Usefulness of a Prothetic Absorbable Mesh in Incisional Hernia Prevention After Midline Laparotomy Unknown status NCT02208557 Phase 4
15 Ultrasound-guided Transverses Abdominis Plane Block in Inguinal Herniorrhaphy: Randomized Controlled Clinical Trial Unknown status NCT02299908 Phase 4
16 Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair Completed NCT02128646 Phase 4
17 EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair Completed NCT01801124 Phase 4
18 Open Mesh Versus Suture Repair in Treatment of Abdominal Wall Hernias Completed NCT01018524 Phase 4
19 Safety Study of MotifMESH (cPTFE) in Abdominal Surgery Completed NCT01364233 Phase 4
20 Laparoscopic "DA VINCI" Robot Assisted Abdominal Wall Hernia Repair Completed NCT00908193 Phase 4
21 Comparative Study of Biologic Mesh Versus Repair With Component Separation. Completed NCT01295125 Phase 4
22 Prospective Randomized Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis Completed NCT00614419 Phase 4
23 A Prospective Study in Patients Undergoing Primary Ventral Hernia Repair Using Parietex™ Composite Ventral Patch Completed NCT01848184 Phase 4
24 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia Completed NCT01778387 Phase 4
25 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair Completed NCT01117337 Phase 4
26 PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results Completed NCT00580177 Phase 4
27 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
28 Strattice in Repair of Inguinal Hernias Completed NCT00681291 Phase 4
29 Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias Completed NCT01264003 Phase 4
30 Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair Completed NCT01273818 Phase 4
31 Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia Completed NCT00306839 Phase 4
32 Parietex Progrip Study Completed NCT00827944 Phase 4
33 Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery Completed NCT01521481 Phase 4
34 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
35 Tizanidine and Pain After Herniorrhaphy Completed NCT02016443 Phase 4
36 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine Completed NCT01921231 Phase 4
37 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4
38 Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty Completed NCT01943760 Phase 4
39 Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy Completed NCT01548794 Phase 4
40 Parastomal Reinforcement With Strattice Completed NCT00771407 Phase 4
41 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
42 Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair Completed NCT01141335 Phase 4
43 AbsorbaTack Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
44 Intrathecal Morphine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4
45 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4
46 Hernia Prevention. Effectiveness of Reinforced Tension Line (RTL) Technique Compared With the Conventional Method Completed NCT02136628 Phase 4
47 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
48 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
49 Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery Completed NCT01262599 Phase 4
50 Does the Use of Ropivacaine Facilitates Cholecystectomy by Laparoscopy in Ambulatory Surgery? Completed NCT02085902 Phase 4

Search NIH Clinical Center for Abdominal Wall Defect

Genetic Tests for Abdominal Wall Defect

Genetic tests related to Abdominal Wall Defect:

id Genetic test Affiliating Genes
1 Abnormality of the Abdominal Wall 29

Anatomical Context for Abdominal Wall Defect

MalaCards organs/tissues related to Abdominal Wall Defect:

39
Small Intestine, Liver, Skin, Lung, Breast

Publications for Abdominal Wall Defect

Articles related to Abdominal Wall Defect:

(show top 50) (show all 156)
id Title Authors Year
1
Electrospun biodegradable microfibers induce new collagen formation in a rat abdominal wall defect model: A possible treatment for pelvic floor repair? ( 28306194 )
2017
2
Application of a Silicone Sheet in Negative-Pressure Wound Therapy to Treat an Abdominal Wall Defect after Necrotizing Fasciitis. ( 28194352 )
2017
3
Complex abdominal wall defect repair using biologic porcine matrix. ( 28217988 )
2017
4
Not gastroschisis or omphalocele or anything in between: a novel congenital abdominal wall defect. ( 28271155 )
2017
5
Does a large abdominal wall defect affect lung growth? ( 27692627 )
2016
6
Reconstruction of massive full-thickness abdominal wall defect: successful treatment with nonabsorbable mesh, negative pressure wound therapy, and split-skin grafting. ( 27761251 )
2016
7
Combined Use of an Anterolateral Thigh Flap and Superficial Inferior Epigastric Artery Flap for Reconstruction of an Extensive Abdominal Wall Defect. ( 27975026 )
2016
8
Ventral abdominal wall defect correction in rats with contaminated meshes. ( 27828602 )
2016
9
Reconstruction of an abdominal wall defect with biologic mesh after resection of a desmoid tumor in a patient with a Gardner's syndrome. ( 27538186 )
2016
10
A Neurotized Anterolateral Thigh Flap With a Unique Anastomosis to the Gastroepiploic Artery: A Case Report of a Reconstruction of Composite Abdominal Wall Defect. ( 27499826 )
2016
11
Abdominal Wall Defect Reconstructed by Breast Flaps Using a Mercedes Closure Pattern. ( 26913520 )
2016
12
Metachronous carcinoma of rectum with reconstruction of a full-thickness abdominal wall defect using a pedicled anterolateral thigh flap. ( 27161142 )
2016
13
Mechanical strength vs. degradation of a biologically-derived surgical mesh over time in a rodent full thickness abdominal wall defect. ( 27619242 )
2016
14
Simultaneous abdominal wall defect repair and Tenckhoff catheter placement in candidates for peritoneal dialysis. ( 26621104 )
2015
15
Urinary bladder herniation through a caudoventral abdominal wall defect in a mature cat. ( 26347198 )
2015
16
Complex abdominal wall defect reconstruction using a latissimus dorsi free flap with mesh after malignant tumor resection. ( 26037038 )
2015
17
Combined therapy of NPWT and bipedicled flap as an alternative approach for giant abdominal wall defect with significant visceral edema: report of a case. ( 27252963 )
2015
18
Use of small intestinal submucosal and acellular dermal matrix grafts in giant omphaloceles in neonates and a rabbit abdominal wall defect model. ( 26364879 )
2015
19
A successful early gore-tex reconstruction of an abdominal wall defect in a neonate with Cantrell pentalogy: a case report and literature review. ( 25678967 )
2015
20
A randomized controlled experimental study comparing chitosan coated polypropylene mesh and Proceeda8c mesh for abdominal wall defect closure. ( 26594357 )
2015
21
Use of surgical mesh of different compositions in the correction of the abdominal wall defect in rats. ( 26648152 )
2015
22
Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue. ( 26560427 )
2015
23
Intraperitoneal microdialysis in the postoperative surveillance of infants undergoing surgery for congenital abdominal wall defect: A pilot study. ( 25783347 )
2015
24
Squamous cell carcinoma arising from abdominal wall defect lesion complicated with cloacal exstrophy. ( 25878926 )
2015
25
Severe abdominal wall defect leading to dehiscence in focal dermal hypoplasia (Goltz syndrome). ( 25751343 )
2015
26
Bacterial adhesion to biological versus polymer prosthetic materials used in abdominal wall defect repair: do these meshes show any differences in vitro? ( 25862028 )
2015
27
Meconial peritonitis in a rare association of partial ileal apple-peel atresia with small abdominal wall defect. ( 25573643 )
2014
28
A novel approach to reconstruct a large full thickness abdominal wall defect: successful treatment with MatriDermAr and Split. ( 25041311 )
2014
29
Differential diagnosis of abdominal wall defects - omphalocele versus gastroschisis. ( 24524464 )
2014
30
Reconstruction of full thickness abdominal wall defect following tumor resection: a case report. ( 25033593 )
2014
31
Reconstruction of large-size abdominal wall defect using biodegradable poly-p-dioxanone mesh: an experimental canine study. ( 24625138 )
2014
32
Full thickness abdominal wall defect in growing rats as a model for congenital diaphragmatic hernia prosthetic repair. ( 25280646 )
2014
33
Treatment of a chronic vesicocutaneous fistula and abdominal wall defect after resection of a soft tissue sarcoma using a bipedicled latissimus dorsi and serratus anterior free flap. ( 25040066 )
2014
34
Rectus abdominis muscle malignant fibrous histiocytoma causing a large abdominal wall defect: reconstruction with biological mesh. ( 24653854 )
2014
35
Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study. ( 24707915 )
2014
36
Investigating muscle regeneration with a dermis/small intestinal submucosa scaffold in a rat full-thickness abdominal wall defect model. ( 24889422 )
2014
37
Dermatan sulfate epimerase 1 deficient mice as a model for human abdominal wall defects. ( 25186462 )
2014
38
Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats. ( 25185056 )
2014
39
Carbon nanotubes as VEGF carriers to improve the early vascularization of porcine small intestinal submucosa in abdominal wall defect repair. ( 24648727 )
2014
40
Laparoscopic-assisted surgical reconstruction of a rare congenital abdominal wall defect in two children misdiagnosed with prune-belly syndrome. ( 23270915 )
2013
41
Preparation of poly(l-lactic acid)-modified polypropylene mesh and its antiadhesion in experimental abdominal wall defect repair. ( 23661568 )
2013
42
Repair of the inguinal hernia using the hernia sac to correct the abdominal wall defect. ( 24091173 )
2013
43
Spontaneous intraamniotic hemorrhage in the second trimester mimicking an abdominal wall defect. ( 24592085 )
2013
44
Reconstruction of extensive abdominal wall defect using an eccentric perforator-based pedicled anterolateral thigh flap: a case report. ( 23836365 )
2013
45
Isolated abdominal wall defect with complete liver herniation without a covering or remnant membrane: an ominous sign: case report and review of literature. ( 23311912 )
2013
46
The in vivo evaluation of tissue-based biomaterials in a rat full-thickness abdominal wall defect model. ( 24155173 )
2013
47
MRI findings in fetuses with an abdominal wall defect: gastroschisis, omphalocele, and cloacal exstrophy. ( 23268122 )
2013
48
Use of a pre-expanded "propeller" deep inferior epigastric perforator (DIEP) flap for a large abdominal wall defect. ( 23031631 )
2013
49
Abdominal wall defect repair with biological prosthesis in transplanted patients: single center retrospective analysis and review of the literature. ( 23636834 )
2013
50
Abdominal wall defect with large duodenal disruption treated by a free tissue flap with a help of temporary expandable metallic stent. ( 24266016 )
2013

Variations for Abdominal Wall Defect

ClinVar genetic disease variations for Abdominal Wall Defect:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GJB2 NM_004004.5(GJB2): c.269T> C (p.Leu90Pro) single nucleotide variant Pathogenic rs80338945 GRCh37 Chromosome 13, 20763452: 20763452
2 PLOD1 NM_000302.3(PLOD1): c.1562G> A (p.Trp521Ter) single nucleotide variant Pathogenic rs1057518879 GRCh37 Chromosome 1, 12025628: 12025628

Expression for Abdominal Wall Defect

Search GEO for disease gene expression data for Abdominal Wall Defect.

Pathways for Abdominal Wall Defect

GO Terms for Abdominal Wall Defect

Sources for Abdominal Wall Defect

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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