MCID: ABD010
MIFTS: 33

Abdominal Wall Defect malady

Gastrointestinal, Endocrine categories

Summaries for Abdominal Wall Defect

Sources:
21Genetics Home Reference, 64Wikipedia, 33MalaCards
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Genetics Home Reference:21 An abdominal wall defect is an opening in the abdomen through which various abdominal organs can protrude. This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. There are two main types of abdominal wall defects: omphalocele and gastroschisis. Omphalocele is an opening in the center of the abdominal wall where the umbilical cord meets the abdomen. Organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord and are covered by the same protective membrane that covers the umbilical cord. Gastroschisis is a defect in the abdominal wall, usually to the right of the umbilical cord, through which the large and small intestines protrude (although other organs may sometimes bulge out). There is no membrane covering the exposed organs in gastroschisis.

MalaCards: Abdominal Wall Defect, also known as thyroid hormone plasma membrane transport defect, is related to gastroschisis and omphalocele. An important gene associated with Abdominal Wall Defect is CDKN1C (cyclin-dependent kinase inhibitor 1C (p57, Kip2)). The compound irinotecan have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and small intestine, and related mouse phenotype mortality/aging.

Wikipedia:64 Abdominal Wall defects are a type of congenital defect that allows the stomach,the intestines, or other... more...

Aliases & Classifications for Abdominal Wall Defect

Sources:
21Genetics Home Reference, 61UMLS, 25ICD10
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Related Diseases for Abdominal Wall Defect

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Abdominal Wall Defect via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1gastroschisis30.9ACHE, AFP
2omphalocele30.9ACHE, CDKN1C, AFP
3beckwith-wiedemann syndrome30.3CDKN1C, NSD1
4neural tube defects30.1ACHE, AFP
5spina bifida29.9AFP
6thyroid hormone plasma membrane transport defect10.6
7patent foramen ovale10.4
8glanzmann's thrombasthenia10.4
9takayasu's arteritis10.4
10atrioventricular septal defect10.4
11atrial heart septal defect10.4
12urea cycle disorder10.4
13hereditary folate malabsorption10.4
14zap70-related severe combined immunodeficiency10.4
15acro-pectoro-renal field defect10.4
16ankle defects short stature10.4
17axial mesodermal dysplasia spectrum10.4
18branchial arch defects10.4
19cardioskeletal syndrome kuwaiti type10.4
20sacral defect with anterior meningocele10.4
21caudal regression syndrome10.4
22chylomicron retention disease10.4
23x-linked creatine deficiency10.4
24cystinosis, ocular nonnephropathic10.4
25hmg coa lyase deficiency10.4
26imerslund-grasbeck syndrome10.4
27defective apolipoprotein b-10010.4
28diaphragmatic hernia upper limb defects10.4
29peroxisome disorders10.4
30heart defect, tongue hamartoma and polysyndactyly10.4
31hermansky pudlak syndrome 210.4
32heterotaxy10.4
33red cell phospholipid defect with hemolysis10.4
34hyperthermia induced defects10.4
35lateral body wall defect10.4
36laterality defects dominant10.4
37limb reduction defect10.4
38overgrowth radial ray defect arthrogryposis10.4
39paraomphalocele10.4
40reductional transverse limb defects10.4
41renal agenesis meningomyelocele mullerian defect10.4
42trigonomacrocephaly tibial defect polydactyly10.4
43thyroid hormonogenesis defect i10.4
44combined oxidative phosphorylation deficiency 210.4
45combined oxidative phosphorylation deficiency 510.4
46combined oxidative phosphorylation deficiency 410.4
47combined oxidative phosphorylation deficiency 710.4
48combined oxidative phosphorylation deficiency 810.4
49combined oxidative phosphorylation deficiency 1010.4
50critical congenital heart disease10.4

Graphical network of the top 20 diseases related to Abdominal Wall Defect:



Diseases related to abdominal wall defect

Clinical Features for Abdominal Wall Defect

Drugs & Therapeutics for Abdominal Wall Defect

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Abdominal Wall Defect

Anatomical Context for Abdominal Wall Defect

Sources:
33MalaCards
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MalaCards organs/tissues related to Abdominal Wall Defect:

33
Skin, Liver, Small intestine, Thyroid, Fetal liver

Animal Models for Abdominal Wall Defect or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Abdominal Wall Defect:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5ACHE, RTL1, CDKN1C, AFP, NSD1

Publications for Abdominal Wall Defect

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51PubMed
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Articles related to Abdominal Wall Defect:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Abdominal wall defect with large duodenal disruption treated by a free tissue flap with a help of temporary expandable metallic stent. (24266016)
2013
2
Isolated abdominal wall defect with complete liver herniation without a covering or remnant membrane: an ominous sign: case report and review of literature. (23311912)
2013
3
Is muscular atrophy a contraindication in laparoscopic abdominal wall defect repair? A prospective study. (22369826)
2012
4
Effects of collagen prosthesis cross-linking on long-term tissue regeneration following the repair of an abdominal wall defect. (22564232)
2012
5
Management of anterior abdominal wall defect using a pedicled tensor fascia lata flap: a case report. (23304156)
2012
6
Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats. (22534804)
2012
7
Birth region, race and sex may affect the prevalence of congenital diaphragmatic hernia, abdominal wall and neural tube defects among US newborns. (22282130)
2012
8
Left-sided congenital abdominal wall defect and intestinal malformation--a rare case. (23008980)
2011
9
Diaphragm electromyogram in infants with abdominal wall defects and congenital diaphragmatic hernia. (20516054)
2011
10
Components separation technique for large abdominal wall defect. (22066088)
2011
11
Reconstruction of a four-quadrant full-thickness abdominal wall defect after removal and debridement of an infected mesh hernioplasty. (20952264)
2011
12
Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome. (20080766)
2010
13
Pedicled omental split skin graft: A novel method for reconstruction of full-thickness abdominal wall defect. (21170199)
2010
14
Reconstruction of a full-thickness abdominal wall defect using an anterolateral thigh free flap. (20692638)
2010
15
Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor. (20692637)
2010
16
New technical approach for the repair of an abdominal wall defect after a transverse rectus abdominis myocutaneous flap: a case report. (18416835)
2008
17
Prosthetic mesh for infected abdominal wall defects? Report of a patient with a large full thickness abdominal wall defect and colostomy due to a gunshot wound. (17499567)
2008
18
Prenatal diagnosis of a fetal abdominal eventration: a rare congenital abdominal wall defect. (18046068)
2008
19
Repair of a full-thickness abdominal wall defect with an innervated latissimus dorsi free flap. (17486522)
2007
20
The sandwich design: a new method to close a high-output enterocutaneous fistula and an associated abdominal wall defect. (17452848)
2007
21
Reconstruction of an abdominal wall defect following wide excision of metastatic squamous cell carcinoma at the percutaneous gastrostomy site in a head and neck cancer patient. (19554114)
2006
22
Homologous muscle acellular matrix seeded with autologous myoblasts as a tissue-engineering approach to abdominal wall-defect repair. (15585259)
2005
23
Repair of an abdominal wall defect after a salvage laparotomy for sepsis. (14759790)
2004
24
Neurovascular latissimus dorsi free-flap transfer for reconstruction of a major abdominal-wall defect in a 13-month-old child: late follow-up. (15088208)
2004
25
A rare left-sided abdominal wall defect. (15630647)
2004
26
Prenatal identification of fetal overgrowth, abdominal wall defect, and neural tube defect in pregnancies achieved by assisted reproductive technology. (15164418)
2004
27
Morbidity and quality of life in adult patients with a congenital abdominal wall defect: a questionnaire survey. (12407546)
2002
28
Experimental abdominal wall defect repaired with acellular matrix. (12415348)
2002
29
Risk factors in congenital abdominal wall defects (omphalocele and gastroschisi): a study in a series of 265,858 consecutive births. (11755106)
2001
30
Gastroschisis complicated by midgut atresia, absorption of bowel, and closure of the abdominal wall defect. (11399884)
2001
31
The fetus with an abdominal wall defect. (11392954)
2001
32
Exstrophic abdominal wall defect without bladder exstrophy (pseudo-exstrophy) (9634060)
1998
33
Neurovascular latissimus dorsi free-flap transfer for the reconstruction of a major abdominal-wall defect in a 13-month-old child: case report. (9714041)
1998
34
Understanding gastroschisis: an abdominal wall defect. (9934095)
1998
35
Re: Secondary reconstruction of abdominal wall defects associated with exstrophy of the bladder. (7857058)
1994
36
Prenatal diagnosis and management of the fetus with an abdominal wall defect. (7973787)
1994
37
Immediate reconstruction of chest and abdominal wall defect following high voltage electrical injury. (7880427)
1994
38
A comparison of amniotic fluid alpha-fetoprotein and acetylcholinesterase in the prenatal diagnosis of open neural tube defects and anterior abdominal wall defects. (7681980)
1993
39
Secondary reconstruction of abdominal wall defects associated with exstrophy of the bladder. (8285533)
1993
40
Pulmonary dysfunction after primary closure of an abdominal wall defect and its improvement with bronchodilators. (1386420)
1992
41
Fetal abdominal wall defect: a new complication of vesicoamniotic shunting. (1837455)
1991
42
Transporting the infant with an abdominal wall defect. (2144036)
1990
43
Prenatal sonographic diagnosis of a vesico-allantoic abdominal wall defect. (2521673)
1989
44
Management of the fetus with an abdominal wall defect: experience of 31 cases. (2529348)
1989
45
Surgeon's workshop. Replacement of an abdominal wall defect using expanded PTFE sheet (Gore-tex). (3157798)
1985
46
Congenital abdominal wall defects: gastroschisis and omphalocele. (6211335)
1982
47
Management of enterocutaneous fistulas and problem stomas with silicone casting of the abdominal wall defect. (145809)
1977
48
Management of massive thoraco-abdominal wall defect from close-range shotgun blast. (4254746)
1971
49
Repair of surgical abdominal wall defect with tantalum mesh. (14888505)
1952
50
Successful use of tantalum mesh to repair an abdominal wall defect in the presence of massive fecal contamination. (14835190)
1951

Genetic Variations for Abdominal Wall Defect

Expression for genes affiliated with Abdominal Wall Defect

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Abdominal Wall Defect

Search GEO for disease gene expression data for Abdominal Wall Defect.

Pathways for genes affiliated with Abdominal Wall Defect

Compounds for genes affiliated with Abdominal Wall Defect

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Abdominal Wall Defect according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1irinotecan45 50 1111.3ACHE, AFP

GO Terms for genes affiliated with Abdominal Wall Defect

Products for genes affiliated with Abdominal Wall Defect

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  • Lysates
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Sources for Abdominal Wall Defect

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet