MCID: ABD002
MIFTS: 28

Abducens Nerve Disease

Categories: Rare diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12
Sixth Nerve Palsy 12 72 49
Abducens Nerve Diseases 41 69
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth Cranial Nerve Disorder, Nos 12
Sixth or Abducens Nerve Palsy 12
Disorder of Abducent Nerve 12
Cranial Mononeuropathy Vi 49
Sixth Cranial Nerve Palsy 49
Abducens Nerve Disorder 12
Abducens Nerve Weakness 12
Cranial Nerve Vi Palsy 49
Vith Nerve Paralysis 12
Abducens Nerve Palsy 49
Vith Nerve Disorder 12
6th Nerve Palsy 49
Vi Nerve Palsy 49

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
ICD10 32 H49.2
ICD9CM 34 378.54
MeSH 41 D020434
UMLS 69 C0271355

Summaries for Abducens Nerve Disease

NIH Rare Diseases : 49 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery. Last updated: 10/16/2015

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to congenital abducens nerve palsy and horner's syndrome. Affiliated tissues include eye and brain.

Wikipedia : 72 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 congenital abducens nerve palsy 11.3
2 horner's syndrome 10.2
3 herpes zoster 10.1
4 herpes zoster ophthalmicus 10.1
5 chronic inflammatory demyelinating polyneuropathy 10.0
6 polyneuropathy 10.0
7 papilledema 10.0
8 demyelinating polyneuropathy 10.0
9 esotropia 10.0
10 aneurysm 10.0
11 headache 10.0
12 abducens palsy 9.8
13 myositis 9.8
14 otitis media 9.8
15 ovarian cancer 9.8
16 strabismus 9.8
17 chondrosarcoma 9.8
18 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
19 factor xii deficiency 9.8
20 lymphoma, hodgkin, classic 9.8
21 intracranial hypertension, idiopathic 9.8
22 pituitary hormone deficiency, combined, 2 9.8
23 pendred syndrome 9.8
24 lymphoma, non-hodgkin, familial 9.8
25 meningioma, familial 9.8
26 multiple enchondromatosis, maffucci type 9.8
27 leukemia 9.8
28 sinusitis 9.8
29 lymphoma 9.8
30 thrombosis 9.8
31 xerophthalmia 9.8
32 lymphoblastic leukemia 9.8
33 meningoencephalitis 9.8
34 sphenoid sinusitis 9.8
35 paralytic squint 9.8
36 suppurative otitis media 9.8
37 nephrotic syndrome 9.8
38 duane retraction syndrome 9.8
39 paranasal sinus disease 9.8
40 papilloma 9.8
41 cerebritis 9.8
42 sagittal sinus thrombosis 9.8
43 skull base meningioma 9.8
44 intracranial hypotension 9.8
45 central pontine myelinolysis 9.8
46 intracranial chondrosarcoma 9.8
47 cluster headache 9.8
48 ependymoma 9.8
49 ocular neuromyotonia 9.8
50 isolated duane retraction syndrome 9.8

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070
2 Effects of Ocular Electroacupuncture on Abducens Nerve Palsy Recruiting NCT03099460
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
4 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

38
Eye, Brain

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show all 37)
# Title Authors Year
1
Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy. ( 29299740 )
2018
2
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
3
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
4
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
5
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
6
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
7
Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy. ( 26301375 )
2015
8
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1. ( 25449936 )
2014
9
Malignant transformation of a Schneiderian papilloma presenting with isolated sixth nerve palsy. ( 23244315 )
2013
10
Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report. ( 24188139 )
2013
11
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
12
Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. ( 22743823 )
2012
13
Cluster headache associated with a sixth nerve palsy: a case report. ( 20670995 )
2011
14
Recurrent orbital myositis mimicking sixth nerve palsy: diagnosis with MR imaging. ( 19778999 )
2010
15
Paralytic strabismus: third, fourth, and sixth nerve palsy. ( 20638001 )
2010
16
Herpes zoster ophthalmicus and sixth nerve palsy in a pediatric patient. ( 17361269 )
2007
17
Isolated unilateral sixth nerve palsy as a presenting symptom of cerebral aneurysms. Report of two cases. ( 24299595 )
2007
18
Superior sagittal sinus thrombosis and bilateral sixth-nerve palsy in a child with nephrotic syndrome. ( 17333003 )
2007
19
Isolated sixth nerve palsy secondary to spontaneous intracranial hypotension. ( 17038044 )
2006
20
Recurrent headache and sixth nerve palsy associated with lumbar ependymoma. ( 15726275 )
2005
21
Horner's syndrome and sixth nerve palsy due to herpes zoster ophthalmicus arteritis. ( 15232597 )
2005
22
Bilateral sixth nerve palsy in West Nile meningoencephalitis. ( 15206452 )
2004
23
Factor XII deficiency and recurrent sixth nerve palsy. ( 12598465 )
2003
24
Unilateral corneal anaesthesia and ulceration following squint surgery in a child with Pendred syndrome and bilateral sixth nerve palsy. ( 12928303 )
2003
25
Acute sixth nerve palsy in vitamin A treatment of xerophthalmia. ( 10979654 )
2000
26
Horner's syndrome and sixth nerve palsy. ( 10697242 )
2000
27
Cyclic esotropia after a traumatic sixth nerve palsy in a child. ( 10532729 )
1998
28
Pseudotumor cerebri sine papilledema with unilateral sixth nerve palsy. ( 9532543 )
1998
29
Non-Hodgkin lymphoma with panhypopituitarism, hyperprolactinaemia and sixth nerve palsy. ( 9204025 )
1997
30
Sixth nerve palsy from a CNS lesion in chronic inflammatory demyelinating polyneuropathy. ( 8648345 )
1996
31
MR features of pachymeningitis presenting with sixth-nerve palsy secondary to sphenoid sinusitis. ( 7611085 )
1995
32
Spontaneous remission of papilledema and sixth nerve palsy in acute lymphoblastic leukemia. ( 7951935 )
1994
33
Central bilateral sixth nerve palsy associated with a unilateral preganglionic Horner's syndrome. ( 2971682 )
1988
34
Cavernous sinus infection manifested by Horner's syndrome and ipsilateral sixth nerve palsy. ( 2963028 )
1987
35
Sixth nerve palsy and unilateral Horner's syndrome. ( 3763136 )
1986
36
An unrecognized neurological syndrome: sixth-nerve palsy and Horner's syndrome due to traumatic intracavernous carotid aneurysm. ( 7280987 )
1981
37
Herpes zoster ophthalmicus with sixth nerve palsy. ( 5302943 )
1968

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

GO Terms for Abducens Nerve Disease

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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