MCID: ACN019
MIFTS: 31

Acanthamoeba Keratitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 48 54 68

Characteristics:

Orphanet epidemiological data:

54
acanthamoeba keratitis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA67043
MESH via Orphanet40 D015823
ICD10 via Orphanet31 B60.1+, H19.2*
UMLS via Orphanet69 C0000880

Summaries for Acanthamoeba Keratitis

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Wikipedia:71 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to keratitis and coenzyme q cytochrome c reductase deficiency of. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways is Complement and coagulation cascades. The drug ketoconazole has been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Related Diseases for Acanthamoeba Keratitis

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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.1
2coenzyme q cytochrome c reductase deficiency of10.1APOH, F5
3subcortical arteriosclerotic encephalopathy10.1APOH, F5
4unicentric castleman disease10.1APOH, F5
5classic congenital lipoid adrenal hyperplasia due to star deficency10.1APOH, F5
6pregnancy loss, recurrent 110.0APOH, F5
7collagenous colitis10.0APOH, F5
8thrombophilia due to thrombin defect10.0APOH, F5
9catatrichy10.0APOH, F5
10may-hegglin anomaly10.0APOH, F5
11left-right axis malformations10.0APOH, F5
12transient cerebral ischemia10.0APOH, F5
13cataract10.0
14dacryoadenitis10.0
15budd-chiari syndrome10.0APOH, F5
16thrombophilia10.0APOH, F5
17childhood central nervous system germinoma10.0APOH, F5
18angioedema, hereditary, type iii10.0APOH, F5
19selective iga deficiency disease10.0APOH, F5
20lingual-facial-buccal dyskinesia10.0APOH, F5
21noma10.0APOH, F5
22joint disorders10.0APOH, F5
23cervical mullerian papilloma9.9APOH, F5
24thrombophilia due to activated protein c resistance9.9APOH, F5
25herpes simplex9.9
26keratoconjunctivitis9.9
27choroid necrotic melanoma9.9APOH, F5
28prostate neuroendocrine neoplasm9.9APOH, F5
29factor v deficiency9.9APOH, F5
30ulcerative blepharitis9.9APOH, F5
31preeclampsia/eclampsia 19.8APOH, F5
32pregnancy loss, recurrent 29.8APOH, F5
33uncombable hair syndrome9.8
34pulmonary hypertension9.8
35keratoconus9.8
36keratopathy9.8
37herpes simplex virus keratitis9.8
38trachoma9.8
39corneal neovascularization9.8
40myopia9.8
41sympathetic ophthalmia9.8
42plague9.8
43endophthalmitis9.8
44conjunctivitis9.8
45chronic fatigue syndrome9.8
46chorioretinitis9.8
47photokeratitis9.7APOH, F5
48stroke, ischemic9.7APOH, F5
49blepharoconjunctivitis9.5APOH, F5
50charcot-marie-tooth disease9.4F5, MBL2

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PseudoephedrineapprovedPhase 160690-82-47028
Synonyms:
( )-Pseudoephedrine
(+) threo-2-(methylamino)-1-phenyl-1-propanol
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
pseudoéphédrine
trans-Ephedrine
ψ-ephedrine
2
EphedrineapprovedPhase 1606299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
3Polyhexamethylene biguanidePhase 110
4Vasoconstrictor AgentsPhase 12027
5Respiratory System AgentsPhase 14818
6Pharmaceutical SolutionsPhase 17793
7TetrahydrozolinePhase 1593
8Peripheral Nervous System AgentsPhase 122776
9Autonomic AgentsPhase 19774
10DisinfectantsPhase 1547
11Nasal DecongestantsPhase 1578
12Ophthalmic SolutionsPhase 11092
13Anti-Infective AgentsPhase 121402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy SubjectsCompletedNCT02506257Phase 1
2Retrospective Study of Acanthamoebic Keratitis During the Past 10 YearsRecruitingNCT02763605

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

36
Eye, Retina, Testes

Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. (28079686)
2017
2
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. (27003712)
2016
3
Acanthamoeba keratitis challenges a case report. (27220232)
2016
4
Dacryoadenitis and extraocular muscle inflammation associated with contact lens-related Acanthamoeba keratitis: A case report and review of the literature. (27874294)
2016
5
The Relation of Ocular Surface Irregularity and Visual Disturbance in Early Stage Acanthamoeba Keratitis. (26783979)
2016
6
Laboratory diagnosis of Acanthamoeba keratitis in Hungary. (27576919)
2016
7
The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. (26952591)
2016
8
The Value of Cytology Smears for Acanthamoeba Keratitis. (27403362)
2016
9
Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers in the United States, 2005 through 2011. (27117780)
2016
10
Characterisation and expression analysis of trophozoite and cyst proteins of Acanthamoeba spp. isolated from Acanthamoeba keratitis (AK) patient. (27030419)
2016
11
The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. (27133448)
2016
12
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. (27312210)
2016
13
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis-How to Define Early? (27032028)
2016
14
Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. (26691018)
2016
15
Painless Acanthamoeba Keratitis with Normal Vision. (27870779)
2016
16
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes. (26989955)
2016
17
Nanoemulsions Containing a Coumarin-Rich Extract from Pterocaulon balansae (Asteraceae) for the Treatment of Ocular Acanthamoeba Keratitis. (27225384)
2016
18
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. (25687209)
2015
19
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. (26426333)
2015
20
Crosslinking and corneal cryotherapy in acanthamoeba keratitis - a histological study. (26483144)
2015
21
The role of domestic tap water on Acanthamoeba keratitis in non-contact lens wearers and validation of laboratory methods. (26017346)
2015
22
Autofluorescence Signatures of Seven Pathogens: Preliminary in Vitro Investigations of a Potential Diagnostic for Acanthamoeba Keratitis. (26488626)
2015
23
Chlorhexidine Monotherapy with Adjunctive Topical Corticosteroids for Acanthamoeba Keratitis. (26425310)
2015
24
Medical interventions for acanthamoeba keratitis. (25710134)
2015
25
IL-17A-mediated protection against Acanthamoeba keratitis. (25505284)
2015
26
Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note. (26338079)
2015
27
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment. (26562819)
2015
28
Acanthamoeba keratitis associated with intracorneal hydrogel inlay. (26563837)
2015
29
Acanthamoeba keratitis: improving the Scottish diagnostic service for the rapid molecular detection of Acanthamoeba species. (25976006)
2015
30
Clinical Course of Unilateral Acanthamoeba Keratitis in a Cosmetic Contact Lens Wearer. (26116606)
2015
31
Contact Lens-Related Acanthamoeba Keratitis and Accompanying Dacryoadenitis. (25603441)
2015
32
Acanthamoeba keratitis: 10-Year study at a tertiary eye care center in Hong Kong. (25496910)
2015
33
Genotypic characterization of amoeba isolated from Acanthamoeba keratitis in Poland. (25604673)
2015
34
Comparison of Fluorescence Microscopy and Different Growth Media Culture Methods for Acanthamoeba Keratitis Diagnosis. (25962772)
2015
35
Investigation of the Role of Bacteria in the Development of Acanthamoeba Keratitis. (26203748)
2015
36
A Rabbit Model of Acanthamoeba Keratitis That Better Reflects the Natural Human Infection. (25766300)
2015
37
Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. (26682216)
2015
38
Acanthamoeba keratitis: clinical characteristics and management. (25881999)
2015
39
Autophagy inhibitors as a potential anti-amoebic treatment for Acanthamoeba keratitis. (25896709)
2015
40
Identifying differentially expressed genes in trophozoites and cysts of Acanthamoeba T4 genotype: Implications for developing new treatments for Acanthamoeba keratitis. (25543551)
2015
41
Acanthamoeba keratitis: a new normal. (25012982)
2014
42
Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan. (24548160)
2014
43
INFLUENCE OF ACANTHAMOEBA GENOTYPE ON CLINICAL COURSE AND OUTCOMES OF PATIENTS WITH ACANTHAMOEBA KERATITIS IN SPAIN. (24430449)
2014
44
Clinical characteristics of acanthamoeba keratitis infections in 28 States, 2008 to 2011. (24322804)
2014
45
The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis. (24630688)
2014
46
Current advances in diagnostic methods of Acanthamoeba keratitis. (25189964)
2014
47
Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. (25262318)
2014
48
InA Vivo Imaging of Radial Keratoneuritis in Patients with Acanthamoeba keratitis by Anterior-Segment Optical Coherence Tomography. (24935283)
2014
49
A new in vivo confocal microscopy prognostic factor in Acanthamoeba keratitis. (24398386)
2014
50
Recommendations for the management of Acanthamoeba keratitis. (24509420)
2014

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0F5, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.7APOH, CXCL2, F5, MBL2
2extracellular spaceGO:00056158.0APOH, CXCL2, F5, MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00025769.3APOH, F5

Molecular functions related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.0F5, MBL2

Sources for Acanthamoeba Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet