MCID: ACN019
MIFTS: 22

Acanthamoeba Keratitis malady

Infectious diseases category

Summaries for Acanthamoeba Keratitis

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards: Acanthamoeba Keratitis is related to keratitis and deep keratitis. An important gene associated with Acanthamoeba Keratitis is MBL2 (mannose-binding lectin (protein C) 2, soluble). The drug ketoconazole and the compounds rantes and ethanol have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
acanthamoeba keratitis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acanthamoeba keratitis 48 60


External Ids:

MESH via Orphanet35 D015823
ICD10 via Orphanet26 B60.1+, H19.2*
SNOMED-CT via Orphanet57 231896005
UMLS via Orphanet61 C0000880

Related Diseases for Acanthamoeba Keratitis

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17GeneCards, 18GeneDecks
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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis32.1CXCL2
2deep keratitis10.5
3exposure keratitis10.4
4cataract10.4
5herpes simplex10.3
6keratoconjunctivitis10.3
7trachoma10.1
8chronic fatigue syndrome10.1
9sympathetic ophthalmia10.1
10chorioretinitis10.1
11corneal neovascularization10.1
12dacryoadenitis10.1
13endophthalmitis10.1
14glaucoma10.1
15hypertension10.1
16keratoconus10.1
17keratopathy10.1
18myopia10.1
19plague10.1
20superficial keratitis10.1
21meningitis10.0MBL2
22cystic fibrosis10.0MBL2
23gastritis10.0CXCL2
24peritonitis10.0CXCL2
25sepsis10.0MBL2, CXCL2
26viral infectious disease10.0CXCL2, MBL2

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Clinical Features for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acanthamoeba Keratitis

Drug clinical trials:

Search ClinicalTrials for Acanthamoeba Keratitis

Search NIH Clinical Center for Acanthamoeba Keratitis

Search CenterWatch for Acanthamoeba Keratitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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32MalaCards
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MalaCards organs/tissues related to Acanthamoeba Keratitis:

32
Eye

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Genetic Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Compounds for genes affiliated with Acanthamoeba Keratitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes449.2CXCL2, MBL2
2ethanol44 49 11 2412.2CXCL2, MBL2
3fibrinogen449.1CXCL2, MBL2
4nitric oxide44 11 2411.1CXCL2, MBL2
5dexamethasone44 49 28 1112.0MBL2, CXCL2
6vegf448.8CXCL2, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Sources:
16Gene Ontology
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Cellular components related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1CXCL2, MBL2

Products for genes affiliated with Acanthamoeba Keratitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acanthamoeba Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet