MCID: ACN019
MIFTS: 41

Acanthamoeba Keratitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 49 55 69

Characteristics:

Orphanet epidemiological data:

55
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Orphanet 55 ORPHA67043
MESH via Orphanet 42 D015823
UMLS via Orphanet 70 C0000880
ICD10 via Orphanet 33 B60.1+ H19.2*
UMLS 69 C0000880

Summaries for Acanthamoeba Keratitis

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Amoebiasis due to free-living amoebae.

MalaCards based summary : Acanthamoeba Keratitis is related to keratitis, hereditary and streptococcal group a invasive disease, and has symptoms including photophobia, punctate opacification of the cornea and ocular pain. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Tetrahydrozoline and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Wikipedia : 72 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 11.2
2 streptococcal group a invasive disease 10.2
3 cataract 10.1
4 dacryoadenitis 10.1
5 may-thurner syndrome 10.1 APOH F5
6 spinal cord infarction 10.1 APOH F5
7 livedoid vasculopathy 10.1 APOH F5
8 cerebral sinovenous thrombosis 10.1 APOH F5
9 pregnancy loss, recurrent 1 10.1 APOH F5
10 prothrombin deficiency, congenital 10.1 APOH F5
11 ischemic colitis 10.0 APOH F5
12 catastrophic antiphospholipid syndrome 10.0 APOH F5
13 sneddon syndrome 10.0 APOH F5
14 retinal artery occlusion 10.0 APOH F5
15 retinal vascular occlusion 10.0 APOH F5
16 intracranial thrombosis 10.0 APOH F5
17 prothrombin deficiency 10.0 APOH F5
18 thrombophlebitis 10.0 APOH F5
19 factor xii deficiency 10.0 APOH F5
20 herpes simplex 10.0
21 keratoconjunctivitis 10.0
22 antithrombin iii deficiency 10.0 APOH F5
23 carotid artery occlusion 10.0 APOH F5
24 peripheral vertigo 10.0 APOH F5
25 central retinal vein occlusion 10.0 APOH F5
26 portal vein thrombosis 10.0 APOH F5
27 protein s deficiency 10.0 APOH F5
28 placental abruption 10.0 APOH F5
29 ischemic optic neuropathy 10.0 APOH F5
30 intracranial hypertension 10.0 APOH F5
31 retinal vein occlusion 10.0 APOH F5
32 thrombophilia due to activated protein c resistance 10.0 APOH F5
33 placenta disease 10.0 APOH F5
34 thrombophilia due to thrombin defect 10.0 APOH F5
35 severe pre-eclampsia 10.0 APOH F5
36 budd-chiari syndrome 9.9 APOH F5
37 antiphospholipid syndrome 9.9 APOH F5
38 pulmonary embolism 9.9 APOH F5
39 patent foramen ovale 9.9 APOH F5
40 thrombosis 9.9 APOH F5
41 blood group, i system 9.9
42 uncombable hair syndrome 1 9.9
43 pulmonary hypertension 9.9
44 keratoconus 9.9
45 keratopathy 9.9
46 herpes simplex virus keratitis 9.9
47 mucositis 9.9
48 trachoma 9.9
49 corneal neovascularization 9.9
50 myopia 9.9

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Human phenotypes related to Acanthamoeba Keratitis:

55 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 55 31 hallmark (90%) Very frequent (99-80%) HP:0000613
2 punctate opacification of the cornea 55 31 hallmark (90%) Very frequent (99-80%) HP:0007856
3 ocular pain 55 31 hallmark (90%) Very frequent (99-80%) HP:0200026
4 cataract 55 31 frequent (33%) Frequent (79-30%) HP:0000518
5 iris atrophy 55 31 frequent (33%) Frequent (79-30%) HP:0001089
6 anterior uveitis 55 31 frequent (33%) Frequent (79-30%) HP:0012122
7 decreased corneal sensation 55 31 frequent (33%) Frequent (79-30%) HP:0012155
8 scleritis 55 31 frequent (33%) Frequent (79-30%) HP:0100532
9 corneal perforation 55 31 frequent (33%) Frequent (79-30%) HP:0100583
10 corneal stromal edema 55 31 occasional (7.5%) Occasional (29-5%) HP:0012040
11 corneal ulceration 55 31 occasional (7.5%) Occasional (29-5%) HP:0012804
12 abnormality of the cornea 55 Very frequent (99-80%)
13 abnormality of corneal epithelium 55 Very frequent (99-80%)
14 abnormality of the posterior segment of the globe 55 Frequent (79-30%)
15 abnormality of the anterior chamber 55 Occasional (29-5%)
16 abnormal anterior chamber morphology 31 occasional (7.5%) HP:0000593
17 abnormal morphology of the posterior segment of the globe 31 frequent (33%) HP:0004329

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tetrahydrozoline Phase 3,Phase 1
2 Ophthalmic Solutions Phase 3,Phase 1
3 Disinfectants Phase 3,Phase 1
4 Hypoglycemic Agents Phase 3,Phase 1
5 Pharmaceutical Solutions Phase 3,Phase 1
6 Anti-Infective Agents Phase 3,Phase 1
7 Polyhexamethylene biguanide Phase 3,Phase 1
8 Dibrompropamidine Phase 3
9 Anti-Infective Agents, Local Phase 3
10 Propamidine Phase 3
11 Antiprotozoal Agents Phase 3
12 Antiparasitic Agents Phase 3
13
Ephedrine Approved Phase 1 299-42-3 9294
14
Pseudoephedrine Approved Phase 1 90-82-4 7028
15 Respiratory System Agents Phase 1
16 Nasal Decongestants Phase 1
17 Vasoconstrictor Agents Phase 1
18 Peripheral Nervous System Agents Phase 1
19 Autonomic Agents Phase 1
20
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
21 Immunosuppressive Agents
22 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
3 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Recruiting NCT02763605
4 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Tacrolimus eye drops;Tobradex eyedrops

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

38
Eye, Retina, Testes

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 519)
# Title Authors Year
1
Factors Influencing the Diagnostic Accuracy of Laser-Scanning In Vivo Confocal Microscopy for Acanthamoeba Keratitis. ( 29303889 )
2018
2
The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation, diagnosis and outcomes (2009-2016). ( 29412494 )
2018
3
Acanthamoeba keratitis in Porto Alegre (southern Brazil): 28 cases and risk factors. ( 29332157 )
2018
4
Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study. ( 28965660 )
2018
5
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach. ( 29357901 )
2018
6
Associated factors, diagnosis and management of Acanthamoeba keratitis in a referral Center in Southern China. ( 28969610 )
2017
7
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
8
Risk factors and clinical features of Acanthamoeba keratitis in a Tunisian tertiary eye care center. ( 28964757 )
2017
9
Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Modelsa8c. ( 28656012 )
2017
10
Comparison of In Vivo Confocal Microscopy, PCR and Culture of Corneal Scrapes in the Diagnosis of Acanthamoeba Keratitis. ( 29256983 )
2017
11
Results with the Boston Type I keratoprosthesis after Acanthamoeba keratitis. ( 29260063 )
2017
12
Acanthamoeba keratitis in noncompliant soft contact lenses users: Genotyping and risk factors, a study from Cairo, Egypt. ( 28965795 )
2017
13
Molecular diagnosis of Acanthamoeba keratitis: evaluation in rat model and application in suspected human cases. ( 28251314 )
2017
14
In-vitro development of an effective treatment for Acanthamoeba keratitis. ( 28709990 )
2017
15
Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis: Case report of aA patient with SjAPgren's syndrome. ( 28386159 )
2017
16
Confocal microscopy as an early relapse marker for acanthamoeba keratitis. ( 28556202 )
2017
17
Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy. ( 28542085 )
2017
18
Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study. ( 28844988 )
2017
19
First time identification of Acanthamoeba genotypes in the cornea samples of wild birds; Is Acanthamoeba keratitis making the predatory birds a target? ( 28807756 )
2017
20
Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis. ( 29296556 )
2017
21
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
22
Acanthamoeba keratitis in patients wearing scleral contact lenses. ( 29221710 )
2017
23
In vivo confocal microscopy and in vitro culture techniques as tools for evaluation of severe Acanthamoeba keratitis incidents ( 29420872 )
2017
24
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28691946 )
2017
25
Evaluation of loop-mediated isothermal amplification assay for rapid diagnosis of Acanthamoeba keratitis. ( 28303825 )
2017
26
A case of non-Acanthamoeba keratitis with radial keratoneuritis. ( 28861362 )
2017
27
Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011. ( 28099282 )
2017
28
A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr. ( 28241309 )
2017
29
Laboratory diagnosis of Acanthamoeba keratitis in Hungary. ( 27576919 )
2016
30
The Relation of Ocular Surface Irregularity and Visual Disturbance in Early Stage Acanthamoeba Keratitis. ( 26783979 )
2016
31
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis-How to Define Early? ( 27032028 )
2016
32
Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. ( 26691018 )
2016
33
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes. ( 26989955 )
2016
34
The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. ( 27133448 )
2016
35
Acanthamoeba keratitis challenges a case report. ( 27220232 )
2016
36
Painless Acanthamoeba Keratitis with Normal Vision. ( 27870779 )
2016
37
The Value of Cytology Smears for Acanthamoeba Keratitis. ( 27403362 )
2016
38
The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. ( 26952591 )
2016
39
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2016
40
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. ( 27003712 )
2016
41
Dacryoadenitis and extraocular muscle inflammation associated with contact lens-related Acanthamoeba keratitis: A case report and review of the literature. ( 27874294 )
2016
42
Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers in the United States, 2005 through 2011. ( 27117780 )
2016
43
Nanoemulsions Containing a Coumarin-Rich Extract from Pterocaulon balansae (Asteraceae) for the Treatment of Ocular Acanthamoeba Keratitis. ( 27225384 )
2016
44
Characterisation and expression analysis of trophozoite and cyst proteins of Acanthamoeba spp. isolated from Acanthamoeba keratitis (AK) patient. ( 27030419 )
2016
45
Comparison of Fluorescence Microscopy and Different Growth Media Culture Methods for Acanthamoeba Keratitis Diagnosis. ( 25962772 )
2015
46
Autofluorescence Signatures of Seven Pathogens: Preliminary in Vitro Investigations of a Potential Diagnostic for Acanthamoeba Keratitis. ( 26488626 )
2015
47
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. ( 26426333 )
2015
48
IL-17A-mediated protection against Acanthamoeba keratitis. ( 25505284 )
2015
49
Chlorhexidine Monotherapy with Adjunctive Topical Corticosteroids for Acanthamoeba Keratitis. ( 26425310 )
2015
50
Crosslinking and corneal cryotherapy in acanthamoeba keratitis - a histological study. ( 26483144 )
2015

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....