MCID: ACN019
MIFTS: 28

Acanthamoeba Keratitis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 45 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
acanthamoeba keratitis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet51 67043
ICD10 via Orphanet28 B60.1+, H19.2*
MESH via Orphanet37 D015823
UMLS via Orphanet66 C0000880

Summaries for Acanthamoeba Keratitis

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Wikipedia:68 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to keratitis and cataract. An important gene associated with Acanthamoeba Keratitis is MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble), and among its related pathways are Spinal Cord Injury and Complement and coagulation cascades. Affiliated tissues include eye, retina and testes.

Related Diseases for Acanthamoeba Keratitis

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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.6
2cataract10.5
3herpes simplex10.4
4keratoconjunctivitis10.4
5pulmonary hypertension10.2
6keratoconus10.2
7keratopathy10.2
8sympathetic ophthalmia10.2
9trachoma10.2
10chronic fatigue syndrome10.2
11chorioretinitis10.2
12corneal neovascularization10.2
13dacryoadenitis10.2
14endophthalmitis10.2
15myopia10.2
16plague10.2
17uncombable hair syndrome10.2
18meningoencephalocele10.1F5, MBL2
19mayer-rokitansky-kuster-hauser syndrome10.0APOH, F5
20monogenic diabetes10.0APOH, F5
21spinocerebellar atrophy10.0APOH, F5
22liver failure acute infantile10.0APOH, F5
23tall stature - scoliosis - macrodactyly of the great toes10.0APOH, F5
24pregnancy loss, recurrent 110.0APOH, F5
25hypoprothrombinemia10.0APOH, F5
26aggressive systemic mastocytosis10.0APOH, F5
27catatrichy10.0APOH, F5
28sesame syndrome10.0APOH, F5
29middle ear adenocarcinoma10.0APOH, F5
30ureter tuberculosis10.0APOH, F5
31panic disorder10.0APOH, F5
32retinal cancer10.0APOH, F5
33budd-chiari syndrome10.0APOH, F5
34retinitis10.0APOH, F5
35factor xii deficiency10.0APOH, F5
36legg-calve-perthes disease10.0APOH, F5
37neurofibroma of spinal cord10.0APOH, F5
38peritoneal benign neoplasm10.0APOH, F5
39intrahepatic cholangiocarcinoma10.0APOH, F5
40vertebral artery insufficiency10.0APOH, F5
41thymic carcinoma9.9APOH, F5
42protein c deficiency9.9APOH, F5
43appendicitis9.9APOH, F5
44disuse amblyopia9.9APOH, F5
45central retinal vein occlusion9.9APOH, F5
46islet cell tumor9.9APOH, F5
47retinitis pigmentosa9.9APOH, F5
48thrombophilia due to activated protein c resistance9.9APOH, F5
49skin glomus tumor9.9APOH, F5
50intracranial sinus thrombosis9.9APOH, F5

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1TetrahydrozolinePhase 1484
2Polyhexamethylene biguanidePhase 19
3DisinfectantsPhase 1376

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy SubjectsNot yet recruitingNCT02506257Phase 1

Search NIH Clinical Center for Acanthamoeba Keratitis

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

33
Eye, Retina, Testes

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 472)
idTitleAuthorsYear
1
Clinical Course of Unilateral Acanthamoeba Keratitis in a Cosmetic Contact Lens Wearer. (26116606)
2015
2
Acanthamoeba keratitis: a new normal. (25012982)
2014
3
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
4
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
5
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
6
Acanthamoeba keratitis--a diagnostic challenge. (22288216)
2011
7
Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. (21155840)
2011
8
Clinical experience with Acanthamoeba keratitis at the cole eye institute, 1999-2008. (20539213)
2010
9
Acanthamoeba keratitis cluster: an increase in Acanthamoeba keratitis in Australia. (19723126)
2009
10
Contact lens-related acanthamoeba keratitis. (19741556)
2009
11
Painless Acanthamoeba keratitis in a soft contact lens wearer--case report. (19860131)
2009
12
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
13
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
14
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
15
Acanthamoeba keratitis related to cosmetic contact lenses. (17997788)
2007
16
Acanthamoeba keratitis. (17157149)
2006
17
Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. (16876498)
2006
18
Six-year review of Acanthamoeba keratitis in New South Wales, Australia: 1997-2002. (15670077)
2005
19
Heidelberg retina tomograph II findings of Acanthamoeba keratitis. (16321898)
2005
20
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
21
Acanthamoeba keratitis in non-contact lens wearers in India: DNA typing-based validation and a simple detection assay. (15477452)
2004
22
Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom. (14691169)
2004
23
Delay in diagnosis and outcome of Acanthamoeba keratitis. (15221303)
2004
24
Arthrographis keratitis mimicking acanthamoeba keratitis. (15084869)
2004
25
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
26
Evaluation of hematoxylin and eosin and special stains for the detection of acanthamoeba keratitis in penetrating keratoplasties. (12967807)
2003
27
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
28
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
29
Evaluation of immunoperoxidase staining technique in the diagnosis of Acanthamoeba keratitis. (15887727)
2001
30
Laser in situ Keratomileusis Following Acanthamoeba Keratitis. (24364509)
2000
31
Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. (11004092)
2000
32
An epidemic of presumed Acanthamoeba keratitis that followed regional flooding. Results of a case-control investigation. (9715690)
1998
33
Acanthamoeba keratitis with symbiosis of Hartmannella ameba. (9625566)
1998
34
Successful medical treatment of Acanthamoeba keratitis. (9700010)
1997-1998
35
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
36
Should we be using polyhexamethylene biguanide to treat Acanthamoeba keratitis? (9267593)
1997
37
Acanthamoeba keratitis: is water exposure a true risk factor? (9001773)
1997
38
Confocal microscopy findings of Acanthamoeba keratitis. (8623881)
1996
39
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. (8944089)
1996
40
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
41
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
42
Acanthamoeba keratitis. (1710209)
1991
43
Examination of hydrophilic contact lenses with light microscopy to aid in the diagnosis of Acanthamoeba keratitis. (2774043)
1989
44
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
45
Elevated corneal epithelial lines in Acanthamoeba keratitis. (3046583)
1988
46
Acanthamoeba keratitis. Potential role for topical clotrimazole in combination chemotherapy. (3046582)
1988
47
Acanthamoeba keratitis. (3307898)
1987
48
Diagnosis and management of Acanthamoeba keratitis. (4037025)
1985
49
Acanthamoeba keratitis successfully treated medically. (4052364)
1985
50
Management of Acanthamoeba keratitis. A case report and review of the literature. (6093021)
1984

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CXCL2, MBL2
2
Show member pathways
9.1F5, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.0APOH, CXCL2, F5, MBL2

Sources for Acanthamoeba Keratitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet