MCID: ACN019
MIFTS: 28

Acanthamoeba Keratitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
46NIH Rare Diseases, 52Orphanet, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 46 52

Characteristics:

Orphanet epidemiological data:

52
acanthamoeba keratitis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet52 ORPHA67043
UMLS via Orphanet67 C0000880
ICD10 via Orphanet29 B60.1+, H19.2*
MESH via Orphanet38 D015823

Summaries for Acanthamoeba Keratitis

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Wikipedia:69 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to keratitis and cataract. An important gene associated with Acanthamoeba Keratitis is MBL2 (Mannose Binding Lectin 2), and among its related pathways is Complement and coagulation cascades. Affiliated tissues include eye, retina and testes.

Related Diseases for Acanthamoeba Keratitis

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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.2
2cataract10.1
3herpes simplex10.0
4keratoconjunctivitis10.0
5dacryoadenitis10.0
6coenzyme q cytochrome c reductase deficiency of9.9APOH, F5
7subcortical arteriosclerotic encephalopathy9.9APOH, F5
8uncombable hair syndrome9.9
9pulmonary hypertension9.9
10keratoconus9.9
11keratopathy9.9
12herpes simplex virus keratitis9.9
13trachoma9.9
14corneal neovascularization9.9
15myopia9.9
16sympathetic ophthalmia9.9
17plague9.9
18endophthalmitis9.9
19conjunctivitis9.9
20chronic fatigue syndrome9.9
21chorioretinitis9.9
22unicentric castleman disease9.9APOH, F5
23classic congenital lipoid adrenal hyperplasia due to star deficency9.9APOH, F5
24pregnancy loss, recurrent 19.9APOH, F5
25collagenous colitis9.9APOH, F5
26thrombophilia due to thrombin defect9.9APOH, F5
27catatrichy9.9APOH, F5
28may-hegglin anomaly9.9APOH, F5
29left-right axis malformations9.9APOH, F5
30transient cerebral ischemia9.9APOH, F5
31budd-chiari syndrome9.8APOH, F5
32thrombophilia9.8APOH, F5
33childhood central nervous system germinoma9.8APOH, F5
34angioedema, hereditary, type iii9.8APOH, F5
35selective iga deficiency disease9.8APOH, F5
36lingual-facial-buccal dyskinesia9.8APOH, F5
37noma9.8APOH, F5
38joint disorders9.8APOH, F5
39cervical mullerian papilloma9.8APOH, F5
40thrombophilia due to activated protein c resistance9.8APOH, F5
41choroid necrotic melanoma9.7APOH, F5
42charcot-marie-tooth disease9.7F5, MBL2
43prostate neuroendocrine neoplasm9.7APOH, F5
44factor v deficiency9.7APOH, F5
45ulcerative blepharitis9.7APOH, F5
46preeclampsia/eclampsia 19.6APOH, F5
47pregnancy loss, recurrent 29.6APOH, F5
48photokeratitis9.5APOH, F5
49stroke, ischemic9.5APOH, F5
50goodpasture syndrome9.4APOH, F5, MBL2

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy SubjectsActive, not recruitingNCT02506257Phase 1
2Retrospective Study of Acanthamoebic Keratitis During the Past 10 YearsRecruitingNCT02763605

Search NIH Clinical Center for Acanthamoeba Keratitis

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

34
Eye, Retina, Testes

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. (27003712)
2016
2
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. (25687209)
2015
3
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. (26426333)
2015
4
Acanthamoeba keratitis: a new normal. (25012982)
2014
5
Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan. (24548160)
2014
6
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
7
Bilateral acanthamoeba keratitis after orthokeratology. (19770731)
2010
8
In vivo and in vitro laser confocal microscopy to diagnose acanthamoeba keratitis. (20508505)
2010
9
MoisturePlus contact lens solution as a source of acanthamoeba keratitis. (19158570)
2009
10
Acanthamoeba keratitis associated with cosmetic contact lens wear. (19098954)
2008
11
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
12
Acanthamoeba keratitis related to cosmetic contact lenses. (17997788)
2007
13
Acanthamoeba keratitis related to orthokeratology. (17377749)
2007
14
Acanthamoeba keratitis. (17157149)
2006
15
Six-year review of Acanthamoeba keratitis in New South Wales, Australia: 1997-2002. (15670077)
2005
16
Granulomatous inflammation in Acanthamoeba keratitis: an immunohistochemical study of five cases and review of literature. (16327118)
2005
17
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
18
In vitro transcorneal penetration of metronidazole and its potential use as adjunct therapy in Acanthamoeba keratitis. (15097135)
2004
19
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
20
Acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment. (14631394)
2003
21
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
22
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
23
Evaluation of immunoperoxidase staining technique in the diagnosis of Acanthamoeba keratitis. (15887727)
2001
24
Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. (11292716)
2001
25
Laser in situ Keratomileusis Following Acanthamoeba Keratitis. (24364509)
2000
26
Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. (11004092)
2000
27
An epidemic of presumed Acanthamoeba keratitis that followed regional flooding. Results of a case-control investigation. (9715690)
1998
28
Acridine orange staining for rapid diagnosis of Acanthamoeba keratitis. (9587842)
1998
29
Successful medical treatment of Acanthamoeba keratitis. (9700010)
1997-1998
30
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
31
Acanthamoeba keratitis: is water exposure a true risk factor? (9001773)
1997
32
Rational drug targeting in Acanthamoeba keratitis: implications of host cell-protozoan interaction. (9474331)
1997
33
Confocal microscopy findings of Acanthamoeba keratitis. (8623881)
1996
34
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. (8944089)
1996
35
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
36
Risk factors for acanthamoeba keratitis. Population study is required to confirm results. (7580456)
1995
37
Acanthamoeba keratitis. (8173450)
1994
38
Drug resistance and Acanthamoeba keratitis: the quest for alternative antiprotozoal chemotherapy. (7835453)
1994
39
Clinical course of Acanthamoeba keratitis. (2047686)
1991
40
Examination of the contact lens with light microscopy: an aid in diagnosis of Acanthamoeba keratitis. (2047685)
1991
41
Acanthamoeba keratitis--resistance to medical therapy. (2101116)
1990
42
Acanthamoeba keratitis in non-contact lens wearers. (2334324)
1990
43
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
44
Elevated corneal epithelial lines in Acanthamoeba keratitis. (3046583)
1988
45
Acanthamoeba keratitis. Potential role for topical clotrimazole in combination chemotherapy. (3046582)
1988
46
Acanthamoeba keratitis. (2458095)
1988
47
Herpes simplex masquerade syndrome: acanthamoeba keratitis. (3829702)
1987
48
Rapid resolution of early Acanthamoeba keratitis after epithelial debridement. (3605288)
1987
49
Rapid diagnosis of Acanthamoeba keratitis using calcofluor white. (2428343)
1986
50
Diagnosis and management of Acanthamoeba keratitis. (4037025)
1985

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1F5, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.0APOH, CXCL2, F5, MBL2
2extracellular regionGO:00055767.7APOH, CXCL2, F5, MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00025769.0APOH, F5

Molecular functions related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.1F5, MBL2

Sources for Acanthamoeba Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet