MCID: ACN019
MIFTS: 31

Acanthamoeba Keratitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 47 53 67

Characteristics:

Orphanet epidemiological data:

53
acanthamoeba keratitis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet53 ORPHA67043
MESH via Orphanet39 D015823
ICD10 via Orphanet30 B60.1+, H19.2*
UMLS via Orphanet68 C0000880

Summaries for Acanthamoeba Keratitis

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Wikipedia:70 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to keratitis and coenzyme q cytochrome c reductase deficiency of. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways is Complement and coagulation cascades. The drug ketoconazole has been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Related Diseases for Acanthamoeba Keratitis

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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.1
2coenzyme q cytochrome c reductase deficiency of10.1APOH, F5
3subcortical arteriosclerotic encephalopathy10.1APOH, F5
4unicentric castleman disease10.1APOH, F5
5classic congenital lipoid adrenal hyperplasia due to star deficency10.1APOH, F5
6pregnancy loss, recurrent 110.0APOH, F5
7collagenous colitis10.0APOH, F5
8thrombophilia due to thrombin defect10.0APOH, F5
9catatrichy10.0APOH, F5
10may-hegglin anomaly10.0APOH, F5
11left-right axis malformations10.0APOH, F5
12transient cerebral ischemia10.0APOH, F5
13cataract10.0
14dacryoadenitis10.0
15budd-chiari syndrome10.0APOH, F5
16thrombophilia10.0APOH, F5
17childhood central nervous system germinoma10.0APOH, F5
18angioedema, hereditary, type iii10.0APOH, F5
19selective iga deficiency disease10.0APOH, F5
20lingual-facial-buccal dyskinesia10.0APOH, F5
21noma10.0APOH, F5
22joint disorders10.0APOH, F5
23cervical mullerian papilloma9.9APOH, F5
24thrombophilia due to activated protein c resistance9.9APOH, F5
25herpes simplex9.9
26keratoconjunctivitis9.9
27choroid necrotic melanoma9.9APOH, F5
28prostate neuroendocrine neoplasm9.9APOH, F5
29factor v deficiency9.9APOH, F5
30ulcerative blepharitis9.9APOH, F5
31preeclampsia/eclampsia 19.8APOH, F5
32pregnancy loss, recurrent 29.8APOH, F5
33uncombable hair syndrome9.8
34pulmonary hypertension9.8
35keratoconus9.8
36keratopathy9.8
37herpes simplex virus keratitis9.8
38trachoma9.8
39corneal neovascularization9.8
40myopia9.8
41sympathetic ophthalmia9.8
42plague9.8
43endophthalmitis9.8
44conjunctivitis9.8
45chronic fatigue syndrome9.8
46chorioretinitis9.8
47photokeratitis9.7APOH, F5
48stroke, ischemic9.7APOH, F5
49blepharoconjunctivitis9.5APOH, F5
50charcot-marie-tooth disease9.4F5, MBL2

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PseudoephedrineapprovedPhase 160690-82-47028
Synonyms:
( )-Pseudoephedrine
(+) threo-2-(methylamino)-1-phenyl-1-propanol
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
pseudoéphédrine
trans-Ephedrine
ψ-ephedrine
2
EphedrineapprovedPhase 1606299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
3Polyhexamethylene biguanidePhase 110
4Vasoconstrictor AgentsPhase 12027
5Respiratory System AgentsPhase 14818
6Pharmaceutical SolutionsPhase 17793
7TetrahydrozolinePhase 1593
8Peripheral Nervous System AgentsPhase 122776
9Autonomic AgentsPhase 19774
10DisinfectantsPhase 1547
11Nasal DecongestantsPhase 1578
12Ophthalmic SolutionsPhase 11092
13Anti-Infective AgentsPhase 121402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy SubjectsCompletedNCT02506257Phase 1
2Retrospective Study of Acanthamoebic Keratitis During the Past 10 YearsRecruitingNCT02763605

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS67/NDF-RT45:

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

35
Eye, Retina, Testes

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. (27003712)
2016
2
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. (25687209)
2015
3
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. (26426333)
2015
4
Acanthamoeba keratitis: a new normal. (25012982)
2014
5
Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan. (24548160)
2014
6
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
7
Bilateral acanthamoeba keratitis after orthokeratology. (19770731)
2010
8
In vivo and in vitro laser confocal microscopy to diagnose acanthamoeba keratitis. (20508505)
2010
9
MoisturePlus contact lens solution as a source of acanthamoeba keratitis. (19158570)
2009
10
Acanthamoeba keratitis associated with cosmetic contact lens wear. (19098954)
2008
11
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
12
Acanthamoeba keratitis related to cosmetic contact lenses. (17997788)
2007
13
Acanthamoeba keratitis related to orthokeratology. (17377749)
2007
14
Acanthamoeba keratitis. (17157149)
2006
15
Six-year review of Acanthamoeba keratitis in New South Wales, Australia: 1997-2002. (15670077)
2005
16
Granulomatous inflammation in Acanthamoeba keratitis: an immunohistochemical study of five cases and review of literature. (16327118)
2005
17
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
18
In vitro transcorneal penetration of metronidazole and its potential use as adjunct therapy in Acanthamoeba keratitis. (15097135)
2004
19
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
20
Acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment. (14631394)
2003
21
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
22
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
23
Evaluation of immunoperoxidase staining technique in the diagnosis of Acanthamoeba keratitis. (15887727)
2001
24
Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. (11292716)
2001
25
Laser in situ Keratomileusis Following Acanthamoeba Keratitis. (24364509)
2000
26
Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. (11004092)
2000
27
An epidemic of presumed Acanthamoeba keratitis that followed regional flooding. Results of a case-control investigation. (9715690)
1998
28
Acridine orange staining for rapid diagnosis of Acanthamoeba keratitis. (9587842)
1998
29
Successful medical treatment of Acanthamoeba keratitis. (9700010)
1997-1998
30
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
31
Acanthamoeba keratitis: is water exposure a true risk factor? (9001773)
1997
32
Rational drug targeting in Acanthamoeba keratitis: implications of host cell-protozoan interaction. (9474331)
1997
33
Confocal microscopy findings of Acanthamoeba keratitis. (8623881)
1996
34
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. (8944089)
1996
35
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
36
Risk factors for acanthamoeba keratitis. Population study is required to confirm results. (7580456)
1995
37
Acanthamoeba keratitis. (8173450)
1994
38
Drug resistance and Acanthamoeba keratitis: the quest for alternative antiprotozoal chemotherapy. (7835453)
1994
39
Clinical course of Acanthamoeba keratitis. (2047686)
1991
40
Examination of the contact lens with light microscopy: an aid in diagnosis of Acanthamoeba keratitis. (2047685)
1991
41
Acanthamoeba keratitis--resistance to medical therapy. (2101116)
1990
42
Acanthamoeba keratitis in non-contact lens wearers. (2334324)
1990
43
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
44
Elevated corneal epithelial lines in Acanthamoeba keratitis. (3046583)
1988
45
Acanthamoeba keratitis. Potential role for topical clotrimazole in combination chemotherapy. (3046582)
1988
46
Acanthamoeba keratitis. (2458095)
1988
47
Herpes simplex masquerade syndrome: acanthamoeba keratitis. (3829702)
1987
48
Rapid resolution of early Acanthamoeba keratitis after epithelial debridement. (3605288)
1987
49
Rapid diagnosis of Acanthamoeba keratitis using calcofluor white. (2428343)
1986
50
Diagnosis and management of Acanthamoeba keratitis. (4037025)
1985

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0F5, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.0APOH, CXCL2, F5, MBL2
2extracellular regionGO:00055767.7APOH, CXCL2, F5, MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00025769.3APOH, F5

Molecular functions related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.0F5, MBL2

Sources for Acanthamoeba Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet