MCID: ACN019
MIFTS: 32

Acanthamoeba Keratitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 50 56 69

Characteristics:

Orphanet epidemiological data:

56
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA67043
MESH via Orphanet 43 D015823
ICD10 via Orphanet 34 B60.1+ H19.2*
UMLS via Orphanet 70 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to keratitis and med13l syndrome. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Wikipedia : 71 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 keratitis 11.1
2 med13l syndrome 10.1 APOH F5
3 vascular erectile tumor 10.1 APOH F5
4 lubinsky syndrome 10.1 APOH F5
5 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.1 APOH F5
6 lung cancer 10.1 APOH F5
7 hendra virus infection 10.1 APOH F5
8 hypertrichosis 10.1 APOH F5
9 left-right axis malformations 10.1 APOH F5
10 lymphocytic colitis 10.1 APOH F5
11 neuronopathy, distal hereditary motor, type iid 10.1 APOH F5
12 bullous skin disease 10.1 APOH F5
13 central congenital hypothyroidism 10.1 APOH F5
14 lynch syndrome 10.1 APOH F5
15 cryptosporidiosis 10.1 APOH F5
16 bladder hepatoid adenocarcinoma 10.1 APOH F5
17 czech dysplasia 10.1 APOH F5
18 angular blepharoconjunctivitis 10.1 APOH F5
19 blepharoconjunctivitis 10.1 APOH F5
20 intestinal disaccharidase deficiency 10.1 APOH F5
21 dysgammaglobulinemia 10.1 APOH F5
22 ophthalmia neonatorum 10.1 APOH F5
23 pregnancy loss, recurrent 2 10.0 APOH F5
24 scar contracture 10.0 APOH F5
25 uterine corpus cancer 10.0 APOH F5
26 pregnancy loss, recurrent 1 10.0 APOH F5
27 thrombophilia due to activated protein c resistance 10.0 APOH F5
28 spinal multifocal clear cell meningioma 10.0 APOH F5
29 exophthalmic ophthalmoplegia 10.0 APOH F5
30 immunodeficiency, common variable, 6 10.0 APOH F5
31 sertoli-leydig cell tumor 10.0 APOH F5
32 leukocyte disease 10.0 APOH F5
33 cataract 10.0
34 dacryoadenitis 10.0
35 welander distal myopathy 10.0 APOH F5
36 bone development disease 10.0 APOH F5
37 dentine erosion 10.0 APOH F5
38 obstructive jaundice 10.0 APOH F5
39 giant papillary conjunctivitis 10.0 APOH F5
40 mental retardation hypotonia skin hyperpigmentation 9.9 F5 MBL2
41 chronic tic disorder 9.9 APOH F5
42 herpes simplex 9.9
43 keratoconjunctivitis 9.9
44 acute proliferative glomerulonephritis 9.9 APOH F5
45 pericarditis 9.9 APOH F5
46 childhood type dermatomyositis 9.9 F5 MBL2
47 budd-chiari syndrome 9.8 APOH F5
48 rectum squamous cell carcinoma 9.8 CXCL2 MBL2
49 conjunctivitis 9.8
50 chronic fatigue syndrome 9.8

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 1 299-42-3 9294
2
Pseudoephedrine Approved Phase 1 90-82-4 7028
3 Nasal Decongestants Phase 1
4 Tetrahydrozoline Phase 1
5 Ophthalmic Solutions Phase 1
6 Disinfectants Phase 1
7 Peripheral Nervous System Agents Phase 1
8 Vasoconstrictor Agents Phase 1
9 Pharmaceutical Solutions Phase 1
10 Polyhexamethylene biguanide Phase 1
11 Anti-Infective Agents Phase 1
12 Respiratory System Agents Phase 1
13 Autonomic Agents Phase 1
14
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
15 Immunosuppressive Agents
16 Calcineurin Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1
2 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Recruiting NCT02763605
3 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

39
Eye, Retina, Testes

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 493)
id Title Authors Year
1
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
2
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
3
Acanthamoeba keratitis challenges a case report. ( 27220232 )
2016
4
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2016
5
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis-How to Define Early? ( 27032028 )
2016
6
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes. ( 26989955 )
2016
7
Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. ( 26691018 )
2016
8
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. ( 27003712 )
2016
9
The Relation of Ocular Surface Irregularity and Visual Disturbance in Early Stage Acanthamoeba Keratitis. ( 26783979 )
2016
10
Dacryoadenitis and extraocular muscle inflammation associated with contact lens-related Acanthamoeba keratitis: A case report and review of the literature. ( 27874294 )
2016
11
Characterisation and expression analysis of trophozoite and cyst proteins of Acanthamoeba spp. isolated from Acanthamoeba keratitis (AK) patient. ( 27030419 )
2016
12
The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. ( 26952591 )
2016
13
The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. ( 27133448 )
2016
14
The Value of Cytology Smears for Acanthamoeba Keratitis. ( 27403362 )
2016
15
Laboratory diagnosis of Acanthamoeba keratitis in Hungary. ( 27576919 )
2016
16
Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers in the United States, 2005 through 2011. ( 27117780 )
2016
17
Nanoemulsions Containing a Coumarin-Rich Extract from Pterocaulon balansae (Asteraceae) for the Treatment of Ocular Acanthamoeba Keratitis. ( 27225384 )
2016
18
Painless Acanthamoeba Keratitis with Normal Vision. ( 27870779 )
2016
19
Acanthamoeba keratitis associated with intracorneal hydrogel inlay. ( 26563837 )
2015
20
Clinical Course of Unilateral Acanthamoeba Keratitis in a Cosmetic Contact Lens Wearer. ( 26116606 )
2015
21
Autophagy inhibitors as a potential anti-amoebic treatment for Acanthamoeba keratitis. ( 25896709 )
2015
22
Medical interventions for acanthamoeba keratitis. ( 25710134 )
2015
23
Acanthamoeba keratitis: 10-Year study at a tertiary eye care center in Hong Kong. ( 25496910 )
2015
24
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment. ( 26562819 )
2015
25
Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. ( 26682216 )
2015
26
Contact Lens-Related Acanthamoeba Keratitis and Accompanying Dacryoadenitis. ( 25603441 )
2015
27
Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note. ( 26338079 )
2015
28
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. ( 25687209 )
2015
29
Acanthamoeba keratitis: improving the Scottish diagnostic service for the rapid molecular detection of Acanthamoeba species. ( 25976006 )
2015
30
Comparison of Fluorescence Microscopy and Different Growth Media Culture Methods for Acanthamoeba Keratitis Diagnosis. ( 25962772 )
2015
31
IL-17A-mediated protection against Acanthamoeba keratitis. ( 25505284 )
2015
32
Crosslinking and corneal cryotherapy in acanthamoeba keratitis - a histological study. ( 26483144 )
2015
33
Chlorhexidine Monotherapy with Adjunctive Topical Corticosteroids for Acanthamoeba Keratitis. ( 26425310 )
2015
34
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. ( 26426333 )
2015
35
The role of domestic tap water on Acanthamoeba keratitis in non-contact lens wearers and validation of laboratory methods. ( 26017346 )
2015
36
Autofluorescence Signatures of Seven Pathogens: Preliminary in Vitro Investigations of a Potential Diagnostic for Acanthamoeba Keratitis. ( 26488626 )
2015
37
A Rabbit Model of Acanthamoeba Keratitis That Better Reflects the Natural Human Infection. ( 25766300 )
2015
38
Investigation of the Role of Bacteria in the Development of Acanthamoeba Keratitis. ( 26203748 )
2015
39
Identifying differentially expressed genes in trophozoites and cysts of Acanthamoeba T4 genotype: Implications for developing new treatments for Acanthamoeba keratitis. ( 25543551 )
2015
40
Acanthamoeba keratitis: clinical characteristics and management. ( 25881999 )
2015
41
Genotypic characterization of amoeba isolated from Acanthamoeba keratitis in Poland. ( 25604673 )
2015
42
Clinical characteristics of acanthamoeba keratitis infections in 28 States, 2008 to 2011. ( 24322804 )
2014
43
Treatment of Acanthamoeba Keratitis With Intravenous Pentamidine Before Therapeutic Keratoplasty. ( 25255139 )
2014
44
Deep anterior lamellar keratoplasty for acanthamoeba keratitis complicating the use of Boston scleral lens. ( 24296954 )
2014
45
Development of an immunochromatographic assay kit using fluorescent silica nanoparticles for rapid diagnosis of Acanthamoeba keratitis. ( 25392356 )
2014
46
The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis. ( 24630688 )
2014
47
In vitro evaluations of topical agents to treat Acanthamoeba keratitis. ( 24880905 )
2014
48
InA Vivo Imaging of Radial Keratoneuritis in Patients with Acanthamoeba keratitis by Anterior-Segment Optical Coherence Tomography. ( 24935283 )
2014
49
Recommendations for the management of Acanthamoeba keratitis. ( 24509420 )
2014
50
Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. ( 25262318 )
2014

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Molecular functions related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.62 F5 MBL2

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....