MCID: ACN019
MIFTS: 28

Acanthamoeba Keratitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
45NIH Rare Diseases, 51Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 45 51

Characteristics:

Orphanet epidemiological data:

51
acanthamoeba keratitis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 67043
UMLS via Orphanet66 C0000880
ICD10 via Orphanet28 B60.1+, H19.2*
MESH via Orphanet37 D015823

Summaries for Acanthamoeba Keratitis

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Wikipedia:68 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to hepatitis and adenocarcinoma. An important gene associated with Acanthamoeba Keratitis is MBL2 (Mannose Binding Lectin 2), and among its related pathways is Spinal Cord Injury. Affiliated tissues include eye, breast and prostate.

Related Diseases for Acanthamoeba Keratitis

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Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Polyhexamethylene biguanidePhase 110
2TetrahydrozolinePhase 1542
3Pharmaceutical SolutionsPhase 17004
4Ophthalmic SolutionsPhase 11006
5DisinfectantsPhase 1405
6Anti-Infective AgentsPhase 117220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy SubjectsActive, not recruitingNCT02506257Phase 1
2Retrospective Study of Acanthamoebic Keratitis During the Past 10 YearsRecruitingNCT02763605

Search NIH Clinical Center for Acanthamoeba Keratitis

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

33
Eye, Breast, Prostate, Lung, Endothelial, Liver, Bone

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 474)
idTitleAuthorsYear
1
Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects. (25761575)
2015
2
Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein Ea8>/a8> ice. (24052074)
2013
3
Bevacizumab in age-related macular degeneration: a randomized controlled trial on the effect of injections every 4 weeks, 6 weeks and 8 weeks. (23773796)
2013
4
L-type calcium channel mutations in Japanese patients with inherited arrhythmias. (23575362)
2013
5
Postpartum herpes simplex virus endometritis and disseminated infection in both mother and neonate. (22825269)
2012
6
Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomography. (21732072)
2012
7
Bilateral breast reconstruction with a pedicled transverse rectus abdominis myocutaneous flap after subcutaneous mastectomy for symptomatic injected breasts. (22909241)
2012
8
Progress in nephron sparing therapy for renal cell carcinoma and von Hippel-Lindau disease. (21496837)
2011
9
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
10
Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model. (21182094)
2011
11
A multicolor flow cytometric assay for measurement of platelet-derived microparticles. (19939440)
2010
12
Corticosteroid-binding globulin, cortisol, free cortisol, and sex hormone-binding globulin responses following oral glucose challenge in spinal cord-injured and able-bodied men. (20839151)
2010
13
Therapy-related myeloid sarcoma with an NPM1 mutation. (20858094)
2010
14
Teaching NeuroImages: hiccoughs and vomiting in neuromyelitis optica. (20975046)
2010
15
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases. (19137299)
2009
16
Serum immunoglobulins and risk of infection: how low can you go? (18620738)
2009
17
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. (19435796)
2009
18
A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth. (19855192)
2009
19
Long-term transvenous temporary pacing with active fixation bipolar lead in the management of severe autonomic dysfunction in Miller-Fisher syndrome: a case report. (17267055)
2007
20
No association of EGF polymorphism with schizophrenia in a Japanese population. (15729146)
2005
21
Digestive morphology and enzyme activity in the Andean toad Bufo spinulosus: hard-wired or flexible physiology? (15748855)
2005
22
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. (14961122)
2004
23
HIF-1: an oxygen and metal responsive transcription factor. (14726713)
2004
24
Nuclear translocation and retention of growth hormone. (12810575)
2003
25
Combined arterial switch and Senning operation for congenitally corrected transposition of the great arteries: patient selection and intermediate results. (12658191)
2003
26
Neuroblastoma with expression of erythropoietin resulting in erythrocytosis. (12902921)
2003
27
Human claspin is required for replication checkpoint control. (12766152)
2003
28
In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium. (12603819)
2003
29
Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity. (12370184)
2002
30
Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density. (11930325)
2002
31
Recent advances in Canavan disease. (10645473)
1999
32
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. (10549287)
1999
33
Extra-adrenal nonneuronal epinephrine and phenylethanolamine-N-methyltransferase. (9328029)
1998
34
Differential effects of inhaled budesonide on serum osteocalcin in children and adolescents with asthma. (9814730)
1998
35
Overexpression of nucleoside diphosphate/kinase A/nm23-H1 protein in human lung tumors: association with tumor progression in squamous carcinoma. (8569178)
1996
36
A nuclear post-transcriptional event responsible for overproduction of argininosuccinate synthetase in a canavanine-resistant variant of a human epithelial cell line. (7538074)
1995
37
Epidemiology and natural history of hepatitis C infections in liver transplant recipients. (7602070)
1995
38
Microscopic colitis syndrome. (7615277)
1995
39
Interleukin-4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis. (7986216)
1994
40
Regulation of epithelial cell surface polarity reversal by beta 1 integrins. (7516342)
1994
41
The clinical significance of ABO blood group incompatibility. (8252149)
1993
42
Phenotypic analysis of immature T-lineage cells]. (8254974)
1993
43
Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles. (8349679)
1993
44
Induced myeloid differentiation of K562 cells with downregulation of erythroid and megakaryocytic transcription factors: a novel experimental model for hemopoietic lineage restriction. (8462662)
1993
45
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
46
Asbestos related diseases without asbestosis. (6223683)
1983
47
Detection and staging of primary rectal and rectosigmoid cancer by computed tomography. (7291518)
1981
48
An XYY boy with short stature and a case of Klinefelter's syndrome (XXY) in a family with inversion 9. (699364)
1978
49
Letter to the editor: Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. (1255903)
1976
50
Central retinoschisis. A case developed after central vein thrombosis. (14480367)
1961

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1CXCL2, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Sources for Acanthamoeba Keratitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet