MCID: ACN019
MIFTS: 29

Acanthamoeba Keratitis malady

Infectious category

Summaries for Acanthamoeba Keratitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards: Acanthamoeba Keratitis is related to acanthamoeba infection and exposure keratitis. An important gene associated with Acanthamoeba Keratitis is MBL2 (mannose-binding lectin (protein C) 2, soluble). The drug ketoconazole and the compounds rantes and ethanol have been mentioned in the context of this disorder. Affiliated tissues include retina and t cells.

Aliases & Classifications for Acanthamoeba Keratitis

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
acanthamoeba keratitis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acanthamoeba keratitis 49 61


External Ids:

MESH via Orphanet36 D015823
ICD10 via Orphanet26 B60.1+, H19.2*
SNOMED-CT via Orphanet58 231896005
UMLS via Orphanet62 C0000880

Related Diseases for Acanthamoeba Keratitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1acanthamoeba infection10.5
2exposure keratitis10.4
3stromal keratitis10.3
4trachoma10.2
5chronic fatigue syndrome10.2
6sympathetic ophthalmia10.2
7superficial keratitis10.2
8uncombable hair syndrome10.2
9pediatric hypertension10.2
10herpes simplex virus keratitis10.2
11meningitis10.0MBL2
12cystic fibrosis10.0MBL2
13keratitis10.0CXCL2
14gastritis10.0CXCL2
15peritonitis10.0CXCL2
16sepsis10.0MBL2, CXCL2
17viral infectious disease10.0CXCL2, MBL2

Graphical network of diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Clinical Features for Acanthamoeba Keratitis

Drugs & Therapeutics for Acanthamoeba Keratitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acanthamoeba Keratitis

Drug clinical trials:

Search ClinicalTrials for Acanthamoeba Keratitis

Search NIH Clinical Center for Acanthamoeba Keratitis

Search CenterWatch for Acanthamoeba Keratitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Acanthamoeba Keratitis:

33
Retina, T cells

Animal Models for Acanthamoeba Keratitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Acanthamoeba Keratitis

Sources:
51PubMed
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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 463)
idTitleAuthorsYear
1
Clinical characteristics of acanthamoeba keratitis infections in 28 States, 2008 to 2011. (24322804)
2014
2
Raman microspectroscopy analysis in the treatment of acanthamoeba keratitis. (23977228)
2013
3
Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis. (23132441)
2013
4
Spontaneous lens extrusion: an unusual late complication of Acanthamoeba keratitis. (23456171)
2013
5
Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. (21155840)
2011
6
Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. (20884060)
2011
7
Microbiological cure times in acanthamoeba keratitis. (21637300)
2011
8
Acanthamoeba and Stenotrophomonas maltophilia keratitis with fungal keratitis in the contralateral eye. (21060673)
2010
9
Genotyping of Acanthamoeba isolates and clinical characteristics of patients with Acanthamoeba keratitis in China. (20056772)
2010
10
Treatment with voriconazole in 3 eyes with resistant Acanthamoeba keratitis. (19875089)
2010
11
MoisturePlus contact lens solution as a source of acanthamoeba keratitis. (19158570)
2009
12
Acanthamoeba keratitis: diagnosis and treatment update 2009. (19660733)
2009
13
The plague that won't simply go away: acanthamoeba keratitis. (19426402)
2009
14
Acanthamoeba keratitis associated with cosmetic contact lens wear. (19098954)
2008
15
Bilateral acanthamoeba keratitis. (18222188)
2008
16
Impaired innate immunity of ocular surface is the key bridge between extended contact lens wearing and occurrence of Acanthamoeba keratitis. (17689022)
2008
17
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
18
Acanthamoeba keratitis related to cosmetic contact lenses. (17997788)
2007
19
Bilateral Acanthamoeba keratitis in an experienced two-weekly disposable contact lens wearer. (17630630)
2007
20
Acanthamoeba keratitis multiple states, 2005-2007. (17538529)
2007
21
Updates in Acanthamoeba keratitis. (17224672)
2007
22
Combined acanthamoeba and Stenotrophomonas maltophilia keratitis treated with a conjunctival flap followed by penetrating keratoplasty. (16783158)
2006
23
Acanthamoeba keratitis associated with misuse of daily disposable contact lenses. (16945570)
2006
24
Acanthamoeba keratitis in Kashmir. (16761775)
2005
25
Results of penetrating keratoplasty for visual rehabilitation after Acanthamoeba keratitis. (16376655)
2005
26
First cases of Acanthamoeba keratitis in Slovakia. (15627346)
2004
27
Chorioretinitis after keratitis caused by Acanthamoeba: case report and review of the literature. (11733264)
2001
28
Coexistent adenoviral keratoconjunctivitis and Acanthamoeba keratitis. (11202467)
2000
29
The reculture technique: individualizing the treatment of Acanthamoeba keratitis. (10928758)
2000
30
Role of mucosal IgA in the resistance to Acanthamoeba keratitis. (9856776)
1998
31
Polyhexamethylene biguanide treatment for Acanthamoeba keratitis. (9524039)
1998
32
Ophthaproblem. Contact lens (Acanthamoeba) keratitis. (9721412)
1998
33
Acanthamoeba keratitis in New Zealand, including two cases with in vivo resistance to polyhexamethylene biguanide. (9717755)
1998
34
Outcome of acanthamoeba keratitis treated with polyhexamethyl biguanide and propamidine. (9331195)
1997
35
Treatment of Acanthamoeba keratitis. (8711564)
1996
36
Chlorhexidine or polyhexamethylene biguanide for acanthamoeba keratitis. (7815880)
1995
37
Diagnosis and successful medical treatment of Acanthamoeba keratitis. (7661744)
1995
38
Acanthamoeba keratitis: increasing the index of suspicion. (7780895)
1995
39
Risk factors for acanthamoeba keratitis. Single use disposable contact lenses should cut risk. (7580457)
1995
40
Acanthamoeba keratitis in hard contact lens wearer. (8005652)
1993
41
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
42
Acanthamoeba keratitis following keratoplasty without other identifiable risk factors. (2012540)
1991
43
Scleral ectasia secondary to Acanthamoeba keratitis. (2297998)
1990
44
Oral itraconazole and topical miconazole with dAcbridement for Acanthamoeba keratitis. (2154105)
1990
45
Diagnosis of acanthamoeba keratitis--a report of four cases and review of literature. (2201624)
1990
46
Acanthamoeba keratitis. (2814741)
1989
47
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
48
Rapid resolution of early Acanthamoeba keratitis after epithelial debridement. (3605288)
1987
49
Acanthamoeba keratitis in soft contact lens wearers. A case-control study. (3586292)
1987
50
Medical and surgical treatment of Acanthamoeba keratitis. (3307434)
1987

Genetic Variations for Acanthamoeba Keratitis

Expression for genes affiliated with Acanthamoeba Keratitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

Compounds for genes affiliated with Acanthamoeba Keratitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes459.2CXCL2, MBL2
2ethanol45 50 11 2412.2CXCL2, MBL2
3fibrinogen459.1CXCL2, MBL2
4nitric oxide45 11 2411.1CXCL2, MBL2
5dexamethasone45 50 29 1112.0MBL2, CXCL2
6vegf458.8CXCL2, MBL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1CXCL2, MBL2

Products for genes affiliated with Acanthamoeba Keratitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acanthamoeba Keratitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet