MCID: ACN019
MIFTS: 34

Acanthamoeba Keratitis malady

Infectious diseases, Rare diseases categories
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Summaries for Acanthamoeba Keratitis

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Wikipedia:65 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

MalaCards based summary: Acanthamoeba Keratitis is related to keratitis and cataract. An important gene associated with Acanthamoeba Keratitis is MBL2 (mannose-binding lectin (protein C) 2, soluble). The compounds rantes and ethanol have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Aliases & Classifications for Acanthamoeba Keratitis

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Sources:
48Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Acanthamoeba Keratitis, Aliases & Descriptions:

Name: Acanthamoeba Keratitis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
acanthamoeba keratitis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


External Ids:

MESH via Orphanet35 D015823
ICD10 via Orphanet26 B60.1+, H19.2*
UMLS via Orphanet63 C0000880

Related Diseases for Acanthamoeba Keratitis

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Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.5
2cataract10.4
3herpes simplex10.3
4keratoconjunctivitis10.3
5hypertension10.2
6keratoconus10.2
7keratopathy10.2
8pulmonary hypertension10.2
9sympathetic ophthalmia10.2
10trachoma10.2
11chorioretinitis10.2
12corneal neovascularization10.2
13dacryoadenitis10.2
14endophthalmitis10.2
15myopia10.2
16plague10.2
17uncombable hair syndrome10.2
18blindness10.2
19pneumonia9.9MBL2, CXCL2
20leukemia9.9MBL2, CXCL2
21sepsis9.8CXCL2, MBL2
22viral infectious disease9.8MBL2, CXCL2

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to acanthamoeba keratitis

Symptoms for Acanthamoeba Keratitis

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Drugs & Therapeutics for Acanthamoeba Keratitis

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Drug clinical trials:

Search ClinicalTrials for Acanthamoeba Keratitis

Search NIH Clinical Center for Acanthamoeba Keratitis

Genetic Tests for Acanthamoeba Keratitis

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Anatomical Context for Acanthamoeba Keratitis

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MalaCards organs/tissues related to Acanthamoeba Keratitis:

32
Eye, Retina, Testes

Animal Models for Acanthamoeba Keratitis or affiliated genes

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Publications for Acanthamoeba Keratitis

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Articles related to Acanthamoeba Keratitis:

(show top 50)    (show all 446)
idTitleAuthorsYear
1
Acanthamoeba keratitis: a new normal. (25012982)
2014
2
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
3
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
4
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
5
Acanthamoeba keratitis--a diagnostic challenge. (22288216)
2011
6
Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. (21155840)
2011
7
Clinical experience with Acanthamoeba keratitis at the cole eye institute, 1999-2008. (20539213)
2010
8
Acanthamoeba keratitis cluster: an increase in Acanthamoeba keratitis in Australia. (19723126)
2009
9
Contact lens-related acanthamoeba keratitis. (19741556)
2009
10
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
11
Acanthamoeba keratitis associated with cosmetic contact lens wear. (19098954)
2008
12
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
13
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
14
Acanthamoeba keratitis related to cosmetic contact lenses. (17997788)
2007
15
Acanthamoeba keratitis related to orthokeratology. (17377749)
2007
16
Acanthamoeba keratitis. (17157149)
2006
17
Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. (16876498)
2006
18
Six-year review of Acanthamoeba keratitis in New South Wales, Australia: 1997-2002. (15670077)
2005
19
Heidelberg retina tomograph II findings of Acanthamoeba keratitis. (16321898)
2005
20
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
21
Acanthamoeba keratitis in non-contact lens wearers in India: DNA typing-based validation and a simple detection assay. (15477452)
2004
22
Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom. (14691169)
2004
23
Delay in diagnosis and outcome of Acanthamoeba keratitis. (15221303)
2004
24
Arthrographis keratitis mimicking acanthamoeba keratitis. (15084869)
2004
25
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
26
Evaluation of hematoxylin and eosin and special stains for the detection of acanthamoeba keratitis in penetrating keratoplasties. (12967807)
2003
27
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
28
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
29
Evaluation of immunoperoxidase staining technique in the diagnosis of Acanthamoeba keratitis. (15887727)
2001
30
Laser in situ Keratomileusis Following Acanthamoeba Keratitis. (24364509)
2000
31
Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. (11004092)
2000
32
An epidemic of presumed Acanthamoeba keratitis that followed regional flooding. Results of a case-control investigation. (9715690)
1998
33
Acanthamoeba keratitis with symbiosis of Hartmannella ameba. (9625566)
1998
34
Successful medical treatment of Acanthamoeba keratitis. (9700010)
1997-1998
35
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
36
Should we be using polyhexamethylene biguanide to treat Acanthamoeba keratitis? (9267593)
1997
37
Acanthamoeba keratitis: is water exposure a true risk factor? (9001773)
1997
38
Confocal microscopy findings of Acanthamoeba keratitis. (8623881)
1996
39
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. (8944089)
1996
40
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
41
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
42
Acanthamoeba keratitis. (1710209)
1991
43
Examination of hydrophilic contact lenses with light microscopy to aid in the diagnosis of Acanthamoeba keratitis. (2774043)
1989
44
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
45
Elevated corneal epithelial lines in Acanthamoeba keratitis. (3046583)
1988
46
Acanthamoeba keratitis. Potential role for topical clotrimazole in combination chemotherapy. (3046582)
1988
47
Acanthamoeba keratitis. (3307898)
1987
48
Diagnosis and management of Acanthamoeba keratitis. (4037025)
1985
49
Acanthamoeba keratitis successfully treated medically. (4052364)
1985
50
Management of Acanthamoeba keratitis. A case report and review of the literature. (6093021)
1984

Variations for Acanthamoeba Keratitis

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Expression for genes affiliated with Acanthamoeba Keratitis

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Expression patterns in normal tissues for genes affiliated with Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for genes affiliated with Acanthamoeba Keratitis

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Compounds for genes affiliated with Acanthamoeba Keratitis

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Sources:
44Novoseek, 50PharmGKB, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1rantes449.4MBL2, CXCL2
2ethanol44 50 24 1112.4MBL2, CXCL2
3fibrinogen449.3CXCL2, MBL2
4dexamethasone44 50 28 1112.3MBL2, CXCL2
5vegf449.3MBL2, CXCL2
6nitric oxide44 24 1111.2CXCL2, MBL2
7oxygen44 2410.2MBL2, CXCL2
8estrogen449.1MBL2, CXCL2
9tyrosine449.1MBL2, CXCL2
10lipid449.0CXCL2, MBL2
11serine448.8MBL2, CXCL2

GO Terms for genes affiliated with Acanthamoeba Keratitis

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Cellular components related to Acanthamoeba Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1MBL2, CXCL2
2extracellular spaceGO:0056158.8MBL2, CXCL2

Products for genes affiliated with Acanthamoeba Keratitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Acanthamoeba Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet