MCID: ACN019
MIFTS: 37

Acanthamoeba Keratitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 50 56 69

Characteristics:

Orphanet epidemiological data:

56
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA67043
MESH via Orphanet 43 D015823
UMLS via Orphanet 70 C0000880
ICD10 via Orphanet 34 B60.1+ H19.2*

Summaries for Acanthamoeba Keratitis

NIH Rare Diseases : 50 this condition doesn't have a summary yet. please see our page(s) on amoebiasis due to free-living amoebae.

MalaCards based summary : Acanthamoeba Keratitis is related to keratitis and mcgillivray syndrome, and has symptoms including cataract, abnormality of the anterior chamber and photophobia. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Anti-Infective Agents and Disinfectants have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Wikipedia : 72 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Related Disease Score Top Affiliating Genes
1 keratitis 11.1
2 mcgillivray syndrome 10.2 APOH F5
3 syncope 10.1 APOH F5
4 lockwood feingold syndrome 10.1 APOH F5
5 46,xy ovotesticular disorder of sex development 10.1 APOH F5
6 pregnancy loss, recurrent 1 10.1 APOH F5
7 collagenous colitis 10.1 APOH F5
8 hiv-1 10.1 APOH F5
9 cavernous lymphangioma 10.1 APOH F5
10 glutathioninuria 10.1 APOH F5
11 rheumatoid lung disease 10.1 APOH F5
12 femoral neuropathy 10.1 APOH F5
13 cryptosporidiosis 10.1 APOH F5
14 intestinal pseudo-obstruction 10.1 APOH F5
15 angioedema, hereditary, type iii 10.1 APOH F5
16 myxomatous pattern testicular yolk sac tumor 10.1 APOH F5
17 congenital syphilis 10.1 APOH F5
18 angular blepharoconjunctivitis 10.1 APOH F5
19 stickler sydrome, type i, nonsyndromic ocular 10.1 APOH F5
20 dysgammaglobulinemia 10.1 APOH F5
21 ulcerative stomatitis 10.1 APOH F5
22 blepharoconjunctivitis 10.1 APOH F5
23 glomerulosclerosis, focal segmental, 2 10.1 APOH F5
24 joint disorders 10.0 APOH F5
25 cervix squamous papilloma 10.0 APOH F5
26 sacrococcygeal teratoma 10.0 APOH F5
27 thrombophilia due to activated protein c resistance 10.0 APOH F5
28 cataract 10.0
29 dacryoadenitis 10.0
30 necrotic uveal melanoma 10.0 APOH F5
31 exophthalmic ophthalmoplegia 10.0 APOH F5
32 budd-chiari syndrome 10.0 APOH F5
33 preeclampsia/eclampsia 1 10.0 APOH F5
34 pregnancy loss, recurrent 2 10.0 APOH F5
35 mixed germ cell-sex cord neoplasm 9.9 APOH F5
36 herpes simplex 9.9
37 keratoconjunctivitis 9.9
38 meckel's diverticulum 9.9 APOH F5
39 dentine erosion 9.9 APOH F5
40 bone remodeling disease 9.8 APOH F5
41 mental retardation dysmorphism hypogonadism diabetes 9.8 F5 MBL2
42 acute proliferative glomerulonephritis 9.8 APOH F5
43 uncombable hair syndrome 9.8
44 pulmonary hypertension 9.8
45 keratoconus 9.8
46 keratopathy 9.8
47 herpes simplex virus keratitis 9.8
48 mucositis 9.8
49 trachoma 9.8
50 corneal neovascularization 9.8

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Human phenotypes related to Acanthamoeba Keratitis:

32 (show all 13)
id Description HPO Frequency HPO Source Accession
1 cataract 32 frequent (33%) HP:0000518
2 abnormality of the anterior chamber 32 occasional (7.5%) HP:0000593
3 photophobia 32 hallmark (90%) HP:0000613
4 iris atrophy 32 frequent (33%) HP:0001089
5 abnormality of the posterior segment of the globe 32 frequent (33%) HP:0004329
6 punctate opacification of the cornea 32 hallmark (90%) HP:0007856
7 corneal stromal edema 32 occasional (7.5%) HP:0012040
8 anterior uveitis 32 frequent (33%) HP:0012122
9 decreased corneal sensation 32 frequent (33%) HP:0012155
10 corneal ulceration 32 occasional (7.5%) HP:0012804
11 scleritis 32 frequent (33%) HP:0100532
12 corneal perforation 32 frequent (33%) HP:0100583
13 ocular pain 32 hallmark (90%) HP:0200026

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 3,Phase 1
2 Disinfectants Phase 3,Phase 1
3 Ophthalmic Solutions Phase 3,Phase 1
4 Pharmaceutical Solutions Phase 3,Phase 1
5 Polyhexamethylene biguanide Phase 3,Phase 1
6 Tetrahydrozoline Phase 3,Phase 1
7 Anti-Infective Agents, Local Phase 3
8 Antiparasitic Agents Phase 3
9 Antiprotozoal Agents Phase 3
10 Dibrompropamidine Phase 3
11 Propamidine Phase 3
12
Ephedrine Approved Phase 1 299-42-3 9294
13
Pseudoephedrine Approved Phase 1 90-82-4 7028
14 Autonomic Agents Phase 1
15 Nasal Decongestants Phase 1
16 Peripheral Nervous System Agents Phase 1
17 Respiratory System Agents Phase 1
18 Vasoconstrictor Agents Phase 1
19
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
20 Calcineurin Inhibitors
21 Immunosuppressive Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
3 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Recruiting NCT02763605
4 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Tacrolimus eye drops;Tobradex eyedrops

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

39
Eye, Retina, Testes

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 506)
id Title Authors Year
1
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28691946 )
2017
2
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
3
First time identification of Acanthamoeba genotypes in the cornea samples of wild birds; Is Acanthamoeba keratitis making the predatory birds a target? ( 28807756 )
2017
4
Confocal microscopy as an early relapse marker for acanthamoeba keratitis. ( 28556202 )
2017
5
Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Modelsa8c. ( 28656012 )
2017
6
Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011. ( 28099282 )
2017
7
Evaluation of loop-mediated isothermal amplification assay for rapid diagnosis of Acanthamoeba keratitis. ( 28303825 )
2017
8
In-vitro development of an effective treatment for Acanthamoeba keratitis. ( 28709990 )
2017
9
Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy. ( 28542085 )
2017
10
A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr. ( 28241309 )
2017
11
Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis: Case report of aA patient with SjAPgren's syndrome. ( 28386159 )
2017
12
A case of non-Acanthamoeba keratitis with radial keratoneuritis. ( 28861362 )
2017
13
Molecular diagnosis of Acanthamoeba keratitis: evaluation in rat model and application in suspected human cases. ( 28251314 )
2017
14
Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study. ( 28844988 )
2017
15
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
16
The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. ( 26952591 )
2016
17
Painless Acanthamoeba Keratitis with Normal Vision. ( 27870779 )
2016
18
Laboratory diagnosis of Acanthamoeba keratitis in Hungary. ( 27576919 )
2016
19
Characterisation and expression analysis of trophozoite and cyst proteins of Acanthamoeba spp. isolated from Acanthamoeba keratitis (AK) patient. ( 27030419 )
2016
20
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2016
21
Dacryoadenitis and extraocular muscle inflammation associated with contact lens-related Acanthamoeba keratitis: A case report and review of the literature. ( 27874294 )
2016
22
The Relation of Ocular Surface Irregularity and Visual Disturbance in Early Stage Acanthamoeba Keratitis. ( 26783979 )
2016
23
Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers in the United States, 2005 through 2011. ( 27117780 )
2016
24
The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. ( 27133448 )
2016
25
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes. ( 26989955 )
2016
26
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. ( 27003712 )
2016
27
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis-How to Define Early? ( 27032028 )
2016
28
The Value of Cytology Smears for Acanthamoeba Keratitis. ( 27403362 )
2016
29
Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. ( 26691018 )
2016
30
Nanoemulsions Containing a Coumarin-Rich Extract from Pterocaulon balansae (Asteraceae) for the Treatment of Ocular Acanthamoeba Keratitis. ( 27225384 )
2016
31
Acanthamoeba keratitis challenges a case report. ( 27220232 )
2016
32
Chlorhexidine Monotherapy with Adjunctive Topical Corticosteroids for Acanthamoeba Keratitis. ( 26425310 )
2015
33
Contact Lens-Related Acanthamoeba Keratitis and Accompanying Dacryoadenitis. ( 25603441 )
2015
34
Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. ( 26426333 )
2015
35
Acanthamoeba keratitis: improving the Scottish diagnostic service for the rapid molecular detection of Acanthamoeba species. ( 25976006 )
2015
36
Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. ( 26682216 )
2015
37
Identifying differentially expressed genes in trophozoites and cysts of Acanthamoeba T4 genotype: Implications for developing new treatments for Acanthamoeba keratitis. ( 25543551 )
2015
38
Investigation of the Role of Bacteria in the Development of Acanthamoeba Keratitis. ( 26203748 )
2015
39
IL-17A-mediated protection against Acanthamoeba keratitis. ( 25505284 )
2015
40
The role of domestic tap water on Acanthamoeba keratitis in non-contact lens wearers and validation of laboratory methods. ( 26017346 )
2015
41
Autophagy inhibitors as a potential anti-amoebic treatment for Acanthamoeba keratitis. ( 25896709 )
2015
42
A Rabbit Model of Acanthamoeba Keratitis That Better Reflects the Natural Human Infection. ( 25766300 )
2015
43
Genotypic characterization of amoeba isolated from Acanthamoeba keratitis in Poland. ( 25604673 )
2015
44
Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note. ( 26338079 )
2015
45
Acanthamoeba keratitis associated with intracorneal hydrogel inlay. ( 26563837 )
2015
46
Acanthamoeba keratitis: clinical characteristics and management. ( 25881999 )
2015
47
Crosslinking and corneal cryotherapy in acanthamoeba keratitis - a histological study. ( 26483144 )
2015
48
Autofluorescence Signatures of Seven Pathogens: Preliminary in Vitro Investigations of a Potential Diagnostic for Acanthamoeba Keratitis. ( 26488626 )
2015
49
Medical interventions for acanthamoeba keratitis. ( 25710134 )
2015
50
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. ( 25687209 )
2015

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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