MCID: ACN010
MIFTS: 44

Acanthoma malady

Summaries for Acanthoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT1 (keratin 1), and among its related pathways are NF-KappaB Family Pathway and Glioma. The compounds glutamate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are integument and craniofacial.

Wikipedia:63 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

acanthoma 8 42 10 60


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Disease Ontology8 DOID:174
MeSH34 D049309
NCIt39 C7419

Related Diseases for Acanthoma

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17GeneCards, 18GeneDecks
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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma31.3IVL
2epidermolytic acanthoma30.9KRT1
3keratosis30.4CLEC2A, KRT16, KRT1, KRT10, IVL
4psoriasis30.3KRT1, KRT10, KRIT1, KRT16, IVL, FGF7
5squamous cell carcinoma30.2IVL, PCNA, KRT10, FGFR2, KRT16, FGF7
6molluscum contagiosum29.8IVL
7keratoacanthoma29.8KRT10, PCNA, IVL
8papilloma29.8IVL, KRT10, PCNA
9large cell acanthoma10.5
10acantholytic acanthoma10.5
11pilar sheath acanthoma10.4
12seborrheic keratosis10.2
13cellulitis10.1
14muir-torre syndrome10.1
15epidermodysplasia verruciformis10.1
16onychocytic matricoma10.1
17syringoma10.0KRT1
18monilethrix10.0KRT16
19ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
20epidermolytic hyperkeratosis10.0KRT1, KRT10
21cervical intraepithelial neoplasia10.0KRT10, IVL
22acrocephalosyndactylia10.0FGFR2
23keratoderma10.0KRT16, KRT1
24palmoplantar keratoderma, epidermolytic10.0KRT16, KRT1
25steatocystoma multiplex10.0KRT16, KRT10
26congenital ichthyosiform erythroderma10.0KRT10, IVL
27sarcoma10.0FGF7
28palmoplantar keratosis10.0KRT16, KRT10, KRT1
29nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1, KRT16
30syringocystadenoma papilliferum10.0CLEC2A
31hidradenoma10.0CLEC2A
32oral leukoplakia10.0PCNA, KRT1
33alopecia10.0CLEC2A
34basal cell carcinoma10.0KRT16, KRT10, IVL
35ladd syndrome10.0FGF10, FGFR2
36craniosynostosis10.0FGFR2, FGF10
37middle ear cholesteatoma10.0IVL, PCNA
38adenoameloblastoma10.0PCNA, KRT1
39cervical cancer10.0KRT10, FGF10, IVL
40aorta atresia10.0FGF10, FGFR2
41mucoepidermoid carcinoma10.0IVL, PCNA
42epidermolysis bullosa simplex10.0IVL, KRT16, KRT1, KRT10
43lichen planus10.0IVL, KRT1, KRT16, KRT10
44leukoplakia10.0PCNA, IVL, KRT1
45cleft palate10.0FGF10, FGFR2
46infectious mononucleosis10.0FGFR2, FGF10, FGF7
47meningioma10.0FGFR2, PCNA, KRT1
48synostosis10.0FGFR2, FGF10
49bowen syndrome10.0IVL, PCNA, KRT1, KRT10, KRT16
50hepatocellular carcinoma10.0PCNA, KRT1, KRIT1, FGFR2

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Clinical Features for Acanthoma

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Drugs & Therapeutics for Acanthoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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32MalaCards
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MalaCards organs/tissues related to Acanthoma:

32
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8KRT1, KRT16, FGF10, FGFR2
2MP:00053828.7KRIT1, KRT10, KRT16, FGF10, FGFR2

Publications for Acanthoma

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50PubMed
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Articles related to Acanthoma:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? (23651324)
2013
2
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
3
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
4
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
5
Postauricular pilar sheath acanthoma. (21769237)
2011
6
Epidermolytic acanthoma of the scrotum: A rare mimicker of condyloma acuminatum. (21272497)
2011
7
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
8
Multiple eruptive clear cell acanthoma. (21886743)
2010
9
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. (19719831)
2010
10
Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome. (19461247)
2009
11
Incidental epidermodysplasia verruciformis human papillomavirus infection (EV acanthoma): evidence for 'field cancerization' and a putative cofactor in seborrheic keratosis. (18494819)
2008
12
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
13
Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. (17550563)
2007
14
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
15
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. (14721785)
2003
16
Psoriasis-like dermoscopic pattern of clear cell acanthoma. (12834460)
2003
17
Large cell acanthoma. (12581141)
2003
18
Disseminated epidermolytic acanthoma probably related to trauma. (10583127)
1999
19
A case of clear cell acanthoma presenting as nipple eczema. (10583200)
1999
20
Clear cell acanthoma developing in epidermal nevus. (9350108)
1997
21
Squamous cell carcinoma in situ arising within clear cell acanthoma. (9217802)
1997
22
A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma. (7857120)
1995
23
Disseminated eruptive clear cell acanthoma--a case report with review of the literature. (8033390)
1994
24
Bilateral spectacle frame acanthoma. (7889674)
1994
25
The expression of cytokine messenger-rnas in clear cell acanthoma. (21573585)
1993
26
Large-cell acanthoma is a solar lentigo. (1533104)
1992
27
Large-cell acanthoma. A distinctive keratosis. (1348913)
1992
28
Atypical clear cell acanthoma. (1816126)
1991
29
Large-cell acanthoma of the eyelid. Report of two cases. (1929935)
1991
30
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
31
Polypous clear cell acanthoma. (2393067)
1990
32
Lectin-binding sites in clear cell acanthoma. (2394862)
1990
33
Acanthoma fissuratum. (3410998)
1988
34
Two cases of clear cell acanthoma: an immunohistochemical study. (2450903)
1988
35
Disseminated epidermolytic acanthoma revealed by PUVA. (3770261)
1986
36
Morular metaplasia of the endometrium misdiagnosed as adeno-acanthoma in a patient with tubal pregnancy. A case report. (3787408)
1986
37
Acanthoma induction in psoriasis patients after short-term high potency Goeckerman treatment. (7307574)
1981
38
Pilar acanthoma: a combination of inverted follicular keratosis and sebaceous trichofolliculoma. (7037900)
1981
39
Large cell acanthoma. One of the actinic keratoses. (619783)
1978
40
Degos' clear cell acanthoma. (892125)
1977
41
Squamous acanthoma of the oral mucosa. (4530964)
1974
42
Clear-cell acanthoma. (5497402)
1970
43
Pale cell acanthoma (Degos). (5492656)
1970
44
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
45
Degos' acanthoma (acanthome a cellules claires). A clinical and histological report of nine cases. (4143668)
1966
46
KERATO-ACANTHOMA IN OCULAR PATHOLOGY. (18170810)
1962
47
Kerato-acanthoma: an illustration of its behaviour and surgical management. (13843927)
1959
48
Kerato-acanthoma; a lesion simulating carcinoma of skin. (13374633)
1956
49
Multiple acanthoma (tumor-like keratosis of Poth). (13091403)
1953
50
Adeno-acanthoma of the pyloric portion of the stomach; a case report. (14937813)
1952

Genetic Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Acanthoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7FGF10, FGFR2
2
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9.1FGF7, FGF10, FGFR2
3
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9.1FGFR2, FGF10, FGF7
4
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9.1FGF7, FGF10, FGFR2
5
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9.1FGF7, FGF10, FGFR2
6
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9.1FGF7, FGF10, FGFR2
7
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9.1FGFR2, FGF10, FGF7
8
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9.1FGF7, FGF10, FGFR2
9
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9.1FGFR2, FGF10, FGF7
10
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9.1FGFR2, FGF10, FGF7
11
Development FGF-family signaling
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9.1FGF7, FGF10, FGFR2
12
Hide members
9.1FGF7, FGF10, FGFR2
13
Hide members
9.1FGF7, FGF10, FGFR2

Compounds for genes affiliated with Acanthoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glutamate4410.5KRIT1
2estrogen4410.4IVL
3tazarotene44 1111.2KRT10, KRT1
4isotretinoin44 1111.0KRT16, KRT1, KRT10
5dextran sulfate sodium449.8FGF7, FGF10
6palifermin44 1110.8FGF7, FGFR2
7dithranol449.8KRT16, IVL, KRT10
8calcipotriol44 59 28 1112.8KRT10, KRT16, IVL
9eosin449.7PCNA, KRT10
10dexamethasone44 49 28 1112.7PCNA, KRIT1
11sodium dodecylsulfate449.7IVL, KRT16, KRT1
12selenomethionine44 2410.6PCNA, KRIT1
13gf 109203x44 5910.6KRIT1, IVL, KRT10
14pimonidazole449.5IVL, PCNA
15retinoid449.5KRT16, IVL, KRT10, KRT1
16phenylalanine449.4KRIT1, KRT1, FGFR2
17ceramides449.4IVL, KRT1
18calcitriol44 59 11 2412.3IVL, KRT10, KRT16
19chondroitin sulfate44 2410.3IVL, FGF7, FGFR2
201,25 dihydroxy vitamin d3449.1IVL, FGF7, KRT10, KRT16
21proline449.1IVL, FGFR2, KRT16, KRT1, KRT10
2212-o-tetradecanoylphorbol 13-acetate449.0FGF7, FGFR2, IVL, KRT1
23vitamin d449.0IVL, FGF7, FGFR2, KRT10
24hematoxylin449.0KRT10, PCNA, IVL, KRT1
25steroid449.0FGF7, FGFR2, KRT16, KRT1, KRT10
26heparan sulfate44 2410.0IVL, FGF7, FGF10, FGFR2
27nicotine44 49 28 1112.0IVL, KRT1, PCNA
28thapsigargin44 599.9IVL, PCNA, KRIT1
29cyclophosphamide44 49 1110.8FGFR2, FGF7, PCNA
30adenylate448.7KRIT1, IVL, FGFR2, FGF7
31arginine448.7KRIT1, PCNA, FGFR2, KRT1, KRT10
32tamoxifen44 49 28 1111.7PCNA, FGFR2, FGF7, KRIT1
33aspartate448.6KRIT1, FGF7, KRT1, PCNA
34genistein44 28 59 2 11 2413.6PCNA, FGFR2, FGF7, KRIT1
355fluorouracil448.5FGF7, FGFR2, PCNA, IVL
36cyclosporin a44 28 5910.5IVL, FGF7, PCNA, KRIT1
37heparin44 28 11 2411.4FGF7, FGFR2, FGF10, PCNA
38progesterone44 59 28 11 2412.4FGFR2, PCNA, FGF7, KRT10, KRT1
39glutamine448.4PCNA, KRIT1, IVL, FGF7
40thymidine44 249.3IVL, FGF7, FGFR2, PCNA
41paraffin448.3PCNA, IVL, FGFR2, KRT16, KRT1, KRT10
42suramin44 28 1110.2KRIT1, IVL, PCNA, FGF7, FGFR2
43h2o2448.2PCNA, FGFR2, FGF7, KRIT1
44vegf448.1FGF7, FGF10, FGFR2, PCNA, IVL
45serine448.1KRT1, FGF7, KRIT1, KRT16, KRT10, IVL
46testosterone44 59 11 2411.1FGFR2, PCNA, KRIT1, KRT1, FGF7, FGF10
47cysteine448.0IVL, PCNA, FGFR2, FGF7, KRIT1
48tyrosine447.6FGFR2, FGF10, HPD, KRT1, IVL, KRT10
49bromodeoxyuridine447.6FGF7, KRT1, FGF10, KRT10, IVL, FGFR2
50retinoic acid44 248.3IVL, PCNA, FGFR2, FGF10, FGF7, KRT16

GO Terms for genes affiliated with Acanthoma

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16Gene Ontology
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Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1mesenchymal cell differentiation involved in lung developmentGO:06091510.1FGFR2, FGF10
2branch elongation involved in salivary gland morphogenesisGO:06066710.1FGFR2, FGF10
3mammary gland bud formationGO:06061510.0FGFR2, FGF10
4fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.0FGFR2, FGF10
5lacrimal gland developmentGO:03280810.0FGFR2, FGF10
6epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.0FGF10, FGFR2
7otic vesicle formationGO:03091610.0FGFR2, FGF10
8limb bud formationGO:06017410.0FGF10, FGFR2
9regulation of smoothened signaling pathwayGO:0085899.9FGF10, FGFR2
10embryonic digestive tract morphogenesisGO:0485579.9FGF10, FGFR2
11secretion by lung epithelial cell involved in lung growthGO:0610339.9FGF10, FGF7
12embryonic pattern specificationGO:0098809.8FGF10, FGFR2
13regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8FGF10, FGF7
14positive regulation of keratinocyte migrationGO:0515499.8FGF10, FGF7
15positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.8FGFR2, FGF7
16positive regulation of keratinocyte proliferationGO:0108389.8FGF10, FGF7
17branching involved in salivary gland morphogenesisGO:0604459.7FGF7, FGFR2
18protein localization to cell surfaceGO:0343949.7FGF7, FGF10
19positive chemotaxisGO:0509189.5FGF7, FGF10
20actin cytoskeleton reorganizationGO:0315329.5FGF7, FGF10
21hair follicle morphogenesisGO:0310699.4FGFR2, FGF10, FGF7
22positive regulation of epithelial cell proliferationGO:0506799.4FGFR2, FGF10, FGF7
23insulin receptor signaling pathwayGO:0082869.3FGFR2, FGF10, FGF7
24fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR2, FGF10, FGF7
25Fc-epsilon receptor signaling pathwayGO:0380959.1FGF7, FGF10, FGFR2
26angiogenesisGO:0015259.0KRIT1, FGF10, FGFR2
27epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR2, FGF10, FGF7
28phosphatidylinositol-mediated signalingGO:0480158.6FGF7, FGF10, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor bindingGO:0051049.5FGF7, FGF10
2chemoattractant activityGO:0420569.2FGF7, FGF10
3heparin bindingGO:0082019.0FGF7, FGF10, FGFR2

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet