MCID: ACN010
MIFTS: 31

Acanthoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

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Aliases & Descriptions for Acanthoma:

Name: Acanthoma 11 48 13 68

Classifications:



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Disease Ontology11 DOID:174
MeSH39 D049309
NCIt45 C7419

Summaries for Acanthoma

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NIH Rare Diseases:48 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary: Acanthoma is related to squamous cell carcinoma and clear cell acanthoma. An important gene associated with Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways are Keratinization and Developmental Biology. Affiliated tissues include skin, ovary and testes.

Wikipedia:71 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

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Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma28.4FGF10, FGFR2, HPD, KRT1, KRT10, KRT14
2clear cell acanthoma12.3
3epidermolytic acanthoma12.2
4large cell acanthoma12.2
5pilar sheath acanthoma12.2
6acantholytic acanthoma11.9
7onychocytic matricoma10.9
8bradyopsia10.2KRT1, KRT10
9palmoplantar keratoderma, nonepidermolytic10.2KRT1, KRT10
10episodic angioedema with eosinophilia10.2KRT1, KRT10
11subglottis verrucous carcinoma10.1KRT1, KRT10
12thymus mucoepidermoid carcinoma10.1KRT1, KRT10
13ebola hemorrhagic fever10.1KRT10, KRT14
14anal margin basal cell carcinoma10.1KRT10, KRT14
15partial of retinal vein occlusion10.1FGF10, FGFR2
16dowling-degos disease 110.1KRT10, KRT14
17basaloid squamous cell carcinoma10.1KRT10, KRT14
18female reproductive system disease10.1KRT10, KRT14
19scaphocephaly, maxillary retrusion, and mental retardation10.1FGF10, FGFR2
20secondary corneal edema10.1KRT10, KRT14
21keratosis10.1
22cervical cancer, somatic10.1FGF10, FGFR2
23leptospirosis10.1KRT10, KRT14
24amebiasis10.1FGF10, KRT14
25distal arthrogryposis10.1KRT10, KRT14
26dermatitis, atopic 210.0KRT1, KRT14
27mongolian spot10.0KRT10, KRT14
28chronic mountain sickness10.0KRT1, KRT9
29white sponge nevus 110.0KRT1, KRT9
30cole-carpenter syndrome 110.0KRT1, KRT10
31pachyonychia congenita 210.0KRT10, KRT9
32psoriasis9.9
33vascular dementia9.9FGFR2, KRT10, KRT14
34mixed cell adenoma9.9KRT1, KRT10, KRT14
35colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas9.9KRT1, KRT10, KRT14
36intraocular retinoblastoma9.9KRT1, KRT10, KRT14
37skin papilloma9.9KRT1, KRT14
38bone chondrosarcoma9.9KRT1, KRT14
39autonomic nervous system neoplasm9.9KRT1, KRT10, KRT14
40saddan9.9FGF10, FGFR2
41erdheim-chester disease9.9KRT1, KRT10, KRT9
42ciliary dyskinesia, primary, 1, with or without situs inversus9.9KRT1, KRT10, KRT9
43keratosis palmoplantaris striata iii9.8KRT1, KRT10, KRT9
44carotid artery thrombosis9.8KRT1, KRT10, KRT9
45ichthyosis histrix, curth-macklin type9.8KRT1, KRT10, KRT9
46muir-torre syndrome9.8
47epidermodysplasia verruciformis9.8
48cellulitis9.8
49bowen's disease9.8
50adenoiditis9.6

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms & Phenotypes for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Interventional clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

36
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
Clear Cell Acanthoma of the Areola and Nipple. (27206609)
2016
2
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. (27648388)
2016
3
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. (28007675)
2016
4
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. (26825163)
2016
5
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. (26945829)
2016
6
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. (27185430)
2016
7
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. (26885606)
2016
8
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. (27814733)
2016
9
An Unusual Location of a Pilar Sheath Acanthoma. (26903749)
2015
10
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? (26512188)
2015
11
Dermoscopy of clear cell acanthoma. (25500041)
2015
12
Porokeratotic acanthoma. (25631132)
2015
13
Pilar Sheath Acanthoma Presenting as a Nevus. (26903752)
2015
14
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. (25511379)
2014
15
Clear cell acanthoma of the nipple: another report from Italy. (24626678)
2014
16
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. (25186214)
2014
17
Large cell acanthoma: a debate throughout the decades. (24520512)
2014
18
Pilar sheath acanthoma simulating basal cell carcinoma. (24566580)
2014
19
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. (25151914)
2014
20
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. (25495637)
2014
21
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. (25267214)
2014
22
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. (25607402)
2014
23
Clear cell acanthoma on the dorsum of the hand. (25353276)
2014
24
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. (25184922)
2014
25
Multiple pigmented clear cell acanthoma in an African patient. (25414053)
2014
26
Multiple clear cell acanthoma associated with multiple Bowen's disease. (24898560)
2014
27
Acantholytic dyskeratotic acanthoma: case report and review of the literature. (25126453)
2014
28
An unusual location of a pilar sheath acanthoma. (25368479)
2014
29
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. (24917472)
2014
30
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. (24890648)
2014
31
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. (24750337)
2014
32
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. (23786782)
2013
33
Acanthoma fissuratum on the penis. (21913907)
2013
34
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? (23651324)
2013
35
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
36
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? (24117902)
2013
37
A shiny red papule in an older person. Clear cell acanthoma. (23944729)
2013
38
Solitary epidermolytic acanthoma. (23710687)
2013
39
Clear cell acanthoma. (24087787)
2013
40
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. (23083445)
2013
41
Clear cell acanthoma. (23171155)
2012
42
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. (22568826)
2012
43
Dermoscopic features of reticulated acanthoma (superficial epithelioma) with sebaceous differentiation. (22858895)
2012
44
Rare persistent kerato-acanthoma of left lower eyelid: a case report. (23029833)
2012
45
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
46
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? (21317609)
2011
47
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
48
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
49
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. (21070339)
2011
50
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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Pathways related to Acanthoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.4KRT1, KRT10, KRT14, KRT9
2
Show member pathways
7.6FGF10, FGFR2, KRT1, KRT10, KRT14, KRT9

GO Terms for genes affiliated with Acanthoma

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Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.1KRT1, KRT10
2extracellular matrixGO:00310129.6FGF10, FGFR2, KRT1
3intermediate filamentGO:00058828.4KRT1, KRT10, KRT14, KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1branch elongation involved in salivary gland morphogenesisGO:006066710.4FGF10, FGFR2
2branching involved in salivary gland morphogenesisGO:006044510.4FGF10, FGFR2
3bud elongation involved in lung branchingGO:006044910.4FGF10, FGFR2
4digestive tract developmentGO:004856510.4FGF10, FGFR2
5embryonic digestive tract morphogenesisGO:004855710.4FGF10, FGFR2
6embryonic pattern specificationGO:000988010.4FGF10, FGFR2
7epidermis morphogenesisGO:004873010.4FGF10, FGFR2
8epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4FGF10, FGFR2
9fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.4FGF10, FGFR2
10hair follicle morphogenesisGO:003106910.4FGF10, FGFR2
11inner ear morphogenesisGO:004247210.4FGF10, FGFR2
12lacrimal gland developmentGO:003280810.3FGF10, FGFR2
13limb bud formationGO:006017410.3FGF10, FGFR2
14lung alveolus developmentGO:004828610.3FGF10, FGFR2
15mammary gland bud formationGO:006061510.3FGF10, FGFR2
16mesenchymal cell differentiation involved in lung developmentGO:006091510.3FGF10, FGFR2
17organ growthGO:003526510.3FGF10, FGFR2
18otic vesicle formationGO:003091610.3FGF10, FGFR2
19phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.3FGF10, FGFR2
20positive regulation of epithelial cell proliferationGO:005067910.3FGF10, FGFR2
21positive regulation of Wnt signaling pathwayGO:003017710.2FGF10, FGFR2
22regulation of phosphatidylinositol 3-kinase signalingGO:001406610.1FGF10, FGFR2
23peptide cross-linkingGO:001814910.0KRT1, KRT10
24regulation of smoothened signaling pathwayGO:00085899.9FGF10, FGFR2
25epithelial cell differentiationGO:00308559.8FGF10, FGFR2, KRT14
26epidermis developmentGO:00085449.7FGF10, KRT14, KRT9
27skin epidermis developmentGO:00987739.4KRT1, KRT10
28cornificationGO:00702689.1KRT1, KRT10, KRT14, KRT9
29keratinizationGO:00314249.0KRT1, KRT10, KRT14, KRT9

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.2FGF10, FGFR2
2phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.0FGF10, FGFR2
3structural constituent of epidermisGO:00302809.4KRT1, KRT10

Sources for Acanthoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet