MCID: ACN010
MIFTS: 32

Acanthoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 49 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 41 D049309
NCIt 46 C7419
UMLS 69 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 49 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  The exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. Last updated: 3/26/2012

MalaCards based summary : Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes.

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 33.8 FGF10 FGFR2
2 epidermolytic acanthoma 32.9 KRT1 KRT10 KRT9
3 keratosis 29.6 KRT1 KRT10 KRT9
4 epidermodysplasia verruciformis 29.6 KRT1 KRT10
5 large cell acanthoma 12.3
6 pilar sheath acanthoma 12.3
7 acantholytic acanthoma 12.1
8 onychocytic matricoma 11.0
9 pleuropulmonary blastoma 10.1 FGF10 FGFR2
10 apert syndrome 10.1 FGF10 FGFR2
11 lacrimoauriculodentodigital syndrome 10.1 FGF10 FGFR2
12 erythroderma, ichthyosiform, congenital reticular 10.0 KRT1 KRT10
13 pustulosis of palm and sole 10.0
14 psoriasis 10.0
15 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.0 KRT1 KRT10
16 muenke syndrome 10.0 FGF10 FGFR2
17 striate palmoplantar keratoderma 10.0 KRT1 KRT10
18 filamentary keratitis 10.0 KRT1 KRT10
19 palmoplantar keratoderma, bothnian type 10.0 KRT1 KRT9
20 squamous cell carcinoma 10.0
21 palmoplantar keratoderma, epidermolytic 10.0 KRT1 KRT9
22 epidermolysis bullosa simplex 9.9 KRT1 KRT10
23 pachyonychia congenita 1 9.9 KRT10 KRT9
24 muir-torre syndrome 9.9
25 melanoma 9.9
26 cellulitis 9.9
27 bowen's disease 9.9
28 pfeiffer syndrome 9.9 FGF10 FGFR2
29 cholesteatoma 9.9 FGFR2 KRT10
30 psoriasis 2 9.7
31 basal cell carcinoma 1 9.7
32 psoriasis 7 9.7
33 psoriasis 11 9.7
34 psoriasis 13 9.7
35 adenoiditis 9.7
36 ichthyosis 9.7
37 basal cell carcinoma 9.7
38 papilloma 9.7
39 endometriosis 9.7
40 keratoacanthoma 9.7
41 porokeratosis 9.7
42 inverted follicular keratosis 9.7
43 bullous pemphigoid 9.7
44 molluscum contagiosum 9.7
45 trichofolliculoma 9.7
46 warty dyskeratoma 9.7
47 hypospadias 9.7 FGF10 FGFR2
48 palmoplantar keratoderma, nonepidermolytic 9.6 KRT1 KRT10 KRT9
49 white sponge nevus 1 9.6 KRT1 KRT10 KRT9
50 palmoplantar keratosis 9.6 KRT1 KRT10 KRT9

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

38
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 226)
# Title Authors Year
1
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
2
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
3
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. ( 29085717 )
2017
4
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
5
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2017
6
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2017
7
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
8
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
9
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
10
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
11
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
12
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
13
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
14
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
15
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. ( 28007675 )
2016
16
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
17
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
18
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
19
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
20
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
21
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
22
Porokeratotic acanthoma. ( 25631132 )
2015
23
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
24
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
25
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
26
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014
27
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
28
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
29
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
30
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
31
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
32
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
33
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
34
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2014
35
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
36
An unusual location of a pilar sheath acanthoma. ( 25368479 )
2014
37
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
38
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
39
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
40
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
41
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
42
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
43
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? ( 23651324 )
2013
44
Solitary epidermolytic acanthoma. ( 23710687 )
2013
45
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
46
Clear cell acanthoma. ( 24087787 )
2013
47
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
48
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. ( 23083445 )
2013
49
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
50
Acanthoma fissuratum on the penis. ( 21913907 )
2013

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 FGF10 FGFR2 KRT1 KRT10 KRT9
2
Show member pathways
11.59 KRT1 KRT10 KRT9

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.16 KRT1 KRT10
2 extracellular matrix GO:0031012 9.13 FGF10 FGFR2 KRT1
3 intermediate filament GO:0005882 8.8 KRT1 KRT10 KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.72 KRT1 KRT10 KRT9
2 epidermis development GO:0008544 9.65 FGF10 KRT9
3 phosphatidylinositol phosphorylation GO:0046854 9.65 FGF10 FGFR2
4 lung development GO:0030324 9.65 FGF10 FGFR2
5 cornification GO:0070268 9.65 KRT1 KRT10 KRT9
6 positive regulation of MAPK cascade GO:0043410 9.64 FGF10 FGFR2
7 wound healing GO:0042060 9.64 FGF10 FGFR2
8 fibroblast growth factor receptor signaling pathway GO:0008543 9.63 FGF10 FGFR2
9 epithelial cell differentiation GO:0030855 9.63 FGF10 FGFR2
10 positive regulation of epithelial cell proliferation GO:0050679 9.62 FGF10 FGFR2
11 inner ear morphogenesis GO:0042472 9.62 FGF10 FGFR2
12 peptide cross-linking GO:0018149 9.61 KRT1 KRT10
13 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.61 FGF10 FGFR2
14 positive regulation of Wnt signaling pathway GO:0030177 9.6 FGF10 FGFR2
15 digestive tract development GO:0048565 9.59 FGF10 FGFR2
16 lung alveolus development GO:0048286 9.58 FGF10 FGFR2
17 hair follicle morphogenesis GO:0031069 9.58 FGF10 FGFR2
18 embryonic pattern specification GO:0009880 9.57 FGF10 FGFR2
19 regulation of smoothened signaling pathway GO:0008589 9.56 FGF10 FGFR2
20 embryonic digestive tract morphogenesis GO:0048557 9.54 FGF10 FGFR2
21 organ growth GO:0035265 9.52 FGF10 FGFR2
22 branching involved in salivary gland morphogenesis GO:0060445 9.51 FGF10 FGFR2
23 limb bud formation GO:0060174 9.49 FGF10 FGFR2
24 lacrimal gland development GO:0032808 9.46 FGF10 FGFR2
25 otic vesicle formation GO:0030916 9.43 FGF10 FGFR2
26 bud elongation involved in lung branching GO:0060449 9.4 FGF10 FGFR2
27 epidermis morphogenesis GO:0048730 9.37 FGF10 FGFR2
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.32 FGF10 FGFR2
29 mesenchymal cell differentiation involved in lung development GO:0060915 9.26 FGF10 FGFR2
30 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.16 FGF10 FGFR2
31 mammary gland bud formation GO:0060615 8.96 FGF10 FGFR2
32 branch elongation involved in salivary gland morphogenesis GO:0060667 8.62 FGF10 FGFR2

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF10 FGFR2
2 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF10 FGFR2
3 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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