MCID: ACN010
MIFTS: 42

Acanthoma malady

Summaries for Acanthoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT1 (keratin 1), and among its related pathways are NF-KappaB Family Pathway and Glioma. The compounds glutamate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are integument and craniofacial.

Wikipedia:64 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 35MeSH, 40NCIt
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Aliases & Descriptions:

acanthoma 8 43 10 61


External Ids:

Disease Ontology8 DOID:174
MeSH35 D049309
NCIt40 C7419

Related Diseases for Acanthoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma31.3IVL
2epidermolytic acanthoma31.0KRT1
3squamous cell carcinoma30.2IVL, PCNA, FGFR2, FGF7, KRT16, KRT1
4molluscum contagiosum29.9IVL
5large cell acanthoma10.5
6acantholytic acanthoma10.5
7pilar sheath acanthoma10.4
8epidermal nevus10.2
9muir-torre syndrome10.1
10epidermodysplasia verruciformis10.1
11onychocytic matricoma10.1
12syringoma10.0KRT1
13monilethrix10.0KRT16
14ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
15epidermolytic hyperkeratosis10.0KRT1, KRT10
16cervical intraepithelial neoplasia10.0KRT10, IVL
17acrocephalosyndactylia10.0FGFR2
18keratoderma10.0KRT16, KRT1
19palmoplantar keratoderma, epidermolytic10.0KRT1, KRT16
20steatocystoma multiplex10.0KRT16, KRT10
21congenital ichthyosiform erythroderma10.0KRT10, IVL
22sarcoma10.0FGF7
23palmoplantar keratosis10.0KRT16, KRT1, KRT10
24nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1, KRT16
25syringocystadenoma papilliferum10.0CLEC2A
26hidradenoma10.0CLEC2A
27oral leukoplakia10.0PCNA, KRT1
28alopecia10.0CLEC2A
29basal cell carcinoma10.0KRT10, KRT16, IVL
30ladd syndrome10.0FGFR2, FGF10
31craniosynostosis10.0FGF10, FGFR2
32middle ear cholesteatoma10.0PCNA, IVL
33adenoameloblastoma10.0PCNA, KRT1
34cervical cancer10.0IVL, FGF10, KRT10
35aorta atresia10.0FGF10, FGFR2
36mucoepidermoid carcinoma10.0PCNA, IVL
37epidermolysis bullosa simplex10.0IVL, KRT16, KRT1, KRT10
38lichen planus10.0KRT10, KRT1, KRT16, IVL
39keratoacanthoma10.0IVL, PCNA, KRT10
40leukoplakia10.0KRT1, PCNA, IVL
41cleft palate10.0FGF10, FGFR2
42papilloma10.0KRT10, PCNA, IVL
43infectious mononucleosis10.0FGFR2, FGF10, FGF7
44skin cancer10.0CLEC2A, PCNA
45meningioma10.0KRT1, FGFR2, PCNA
46synostosis10.0FGF10, FGFR2
47bowen syndrome10.0IVL, PCNA, KRT16, KRT1, KRT10
48hepatocellular carcinoma10.0PCNA, FGFR2, KRT1, KRIT1
49cholesteatoma10.0KRT10, KRT16, FGF7, FGFR2, IVL
50retinoblastoma10.0PCNA, FGFR2, KRT10

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Clinical Features for Acanthoma

Drugs & Therapeutics for Acanthoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acanthoma

Drug clinical trials:

Search ClinicalTrials for Acanthoma

Search NIH Clinical Center for Acanthoma

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Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Acanthoma:

33
Skin, Ovary, Liver, Uterus

Animal Models for Acanthoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acanthoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8KRT1, KRT16, FGF10, FGFR2
2MP:00053828.7KRIT1, KRT10, KRT16, FGF10, FGFR2

Publications for Acanthoma

Sources:
51PubMed
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Articles related to Acanthoma:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. (23083445)
2013
2
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
3
Clear cell acanthoma. (23171155)
2012
4
Epidermolytic acanthoma of the scrotum: A rare mimicker of condyloma acuminatum. (21272497)
2011
5
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). (20500186)
2010
6
Linear epidermolytic acanthoma or adult-onset verrucous epidermal nevus? (20827001)
2010
7
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. (19719831)
2010
8
Incidental epidermodysplasia verruciformis human papillomavirus infection (EV acanthoma): evidence for 'field cancerization' and a putative cofactor in seborrheic keratosis. (18494819)
2008
9
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. (17214854)
2007
10
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. (17667172)
2007
11
Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. (17550563)
2007
12
Clear cell acanthoma occurring in a split-thickness skin graft. (16327592)
2005
13
Malignant tumor formation in dogs previously irradiated for acanthomatous epulis. (15373265)
2004
14
Large cell acanthoma. (12581141)
2003
15
Cell proliferation patterns in canine infundibular keratinizing acanthoma and well differentiated squamous cell carcinoma of the skin. (12152794)
2002
16
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. (12226748)
2002
17
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
18
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
19
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
20
A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma. (7857120)
1995
21
Canine acanthomatous epulis. The only common spontaneous ameloblastoma in animals. (7600226)
1995
22
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
23
Disseminated eruptive clear cell acanthoma--a case report with review of the literature. (8033390)
1994
24
Bilateral spectacle frame acanthoma. (7889674)
1994
25
Etretinate therapy of solar-related kerato acanthoma. (8240190)
1993
26
Disseminated epidermolytic acanthoma. (8434736)
1993
27
Large-cell acanthoma of the eyelid. Report of two cases. (1929935)
1991
28
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
29
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
30
Disseminated epidermolytic acanthoma revealed by PUVA. (3770261)
1986
31
Morular metaplasia of the endometrium misdiagnosed as adeno-acanthoma in a patient with tubal pregnancy. A case report. (3787408)
1986
32
Sarcoma development following irradiation of acanthomatous epulis in two dogs. (3461611)
1986
33
Pale cell acanthoma of the scrotum. (7128203)
1982
34
Multiple kerato-acanthoma: a case report. (6162321)
1980
35
Disseminated epidermolytic acanthoma. (500873)
1979
36
Pilar sheath acanthoma. (718186)
1978
37
Large cell acanthoma. One of the actinic keratoses. (619783)
1978
38
Clear cell acanthoma: clinicopathologic analysis of 37 new cases. (4687348)
1973
39
Disseminated epidermolytic acanthoma. Nonsystematized multiple verrucoid lesions showing granular degeneration. (4127475)
1973
40
Multiple clear-cell acanthoma and ichthyosis. (4334961)
1972
41
Clear-cell acanthoma. (5497402)
1970
42
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
43
KERATO-ACANTHOMA IN OCULAR PATHOLOGY. (18170810)
1962
44
Adeno-acanthoma of the uterus. (14407697)
1959
45
Kerato-acanthoma: an illustration of its behaviour and surgical management. (13843927)
1959
46
Molluscum sebaceum (kerato-acanthoma). (14365221)
1955
47
Molluscum sebaceum (kerato-acanthoma) or squamous-cell carcinoma of the lid. (13238534)
1955
48
Kerato-acanthoma. (13189828)
1954
49
Adeno-acanthoma of the pyloric portion of the stomach; a case report. (14937813)
1952
50
Multiple Branchiogenic Acanthoma: Report of a Case. (19970133)
1934

Genetic Variations for Acanthoma

Expression for genes affiliated with Acanthoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
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Pathways related to Acanthoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7FGF10, FGFR2
2
Hide members
9.1FGF7, FGF10, FGFR2
3
Hide members
9.1FGFR2, FGF10, FGF7
4
Hide members
9.1FGF7, FGF10, FGFR2
5
Hide members
9.1FGF7, FGF10, FGFR2
6
Hide members
9.1FGF7, FGF10, FGFR2
7
Hide members
9.1FGFR2, FGF10, FGF7
8
Hide members
9.1FGF7, FGF10, FGFR2
9
Hide members
9.1FGFR2, FGF10, FGF7
10
Hide members
9.1FGFR2, FGF10, FGF7
11
Development FGF-family signaling
Hide members
9.1FGF7, FGF10, FGFR2
12
Hide members
9.1FGF7, FGF10, FGFR2
13
Hide members
9.1FGF7, FGF10, FGFR2

Compounds for genes affiliated with Acanthoma

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glutamate4510.5KRIT1
2estrogen4510.4IVL
3tazarotene45 1111.2KRT1, KRT10
4isotretinoin45 1111.0KRT10, KRT1, KRT16
5dextran sulfate sodium459.8FGF7, FGF10
6palifermin45 1110.8FGF7, FGFR2
7dithranol459.8KRT10, KRT16, IVL
8calcipotriol45 60 29 1112.8KRT10, KRT16, IVL
9eosin459.7KRT10, PCNA
10dexamethasone45 50 29 1112.7PCNA, KRIT1
11sodium dodecylsulfate459.7IVL, KRT16, KRT1
12selenomethionine45 2410.6KRIT1, PCNA
13gf 109203x45 6010.6KRIT1, KRT10, IVL
14pimonidazole459.5IVL, PCNA
15retinoid459.5KRT10, KRT1, KRT16, IVL
16phenylalanine459.4KRIT1, KRT1, FGFR2
17ceramides459.4KRT1, IVL
18calcitriol45 60 11 2412.3KRT10, KRT16, IVL
19chondroitin sulfate45 2410.3FGF7, FGFR2, IVL
201,25 dihydroxy vitamin d3459.1IVL, FGF7, KRT16, KRT10
21proline459.1IVL, FGFR2, KRT16, KRT1, KRT10
2212-o-tetradecanoylphorbol 13-acetate459.0KRT1, FGF7, FGFR2, IVL
23vitamin d459.0KRT10, FGF7, FGFR2, IVL
24hematoxylin459.0IVL, PCNA, KRT1, KRT10
25steroid459.0FGFR2, FGF7, KRT16, KRT1, KRT10
26heparan sulfate45 2410.0IVL, FGFR2, FGF10, FGF7
27nicotine45 50 29 1112.0KRT1, PCNA, IVL
28thapsigargin45 609.9IVL, PCNA, KRIT1
29cyclophosphamide45 50 1110.8PCNA, FGFR2, FGF7
30adenylate458.7IVL, FGFR2, FGF7, KRIT1
31arginine458.7PCNA, FGFR2, KRT1, KRT10, KRIT1
32tamoxifen45 50 29 1111.7PCNA, FGFR2, FGF7, KRIT1
33aspartate458.6KRIT1, KRT1, FGF7, PCNA
34genistein45 29 60 2 11 2413.6KRIT1, FGF7, FGFR2, PCNA
355fluorouracil458.5IVL, PCNA, FGFR2, FGF7
36cyclosporin a45 29 6010.5IVL, PCNA, FGF7, KRIT1
37heparin45 29 11 2411.4PCNA, FGFR2, FGF10, FGF7
38progesterone45 60 29 11 2412.4PCNA, FGFR2, FGF7, KRT1, KRT10
39glutamine458.4KRIT1, FGF7, PCNA, IVL
40thymidine45 249.3IVL, PCNA, FGFR2, FGF7
41paraffin458.3IVL, PCNA, FGFR2, KRT16, KRT1, KRT10
42suramin45 29 1110.2IVL, PCNA, FGFR2, FGF7, KRIT1
43h2o2458.2PCNA, FGFR2, FGF7, KRIT1
44vegf458.1IVL, PCNA, FGFR2, FGF10, FGF7
45serine458.1IVL, FGFR2, FGF7, KRT16, KRT1, KRT10
46testosterone45 60 11 2411.1PCNA, FGFR2, FGF10, FGF7, KRT1, KRIT1
47cysteine458.0IVL, PCNA, FGFR2, FGF7, KRIT1
48tyrosine457.6IVL, HPD, FGFR2, FGF10, FGF7, KRT1
49bromodeoxyuridine457.6KRT10, IVL, PCNA, FGFR2, FGF10, FGF7
50retinoic acid45 248.3IVL, PCNA, FGFR2, FGF10, FGF7, KRT16

GO Terms for genes affiliated with Acanthoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1mesenchymal cell differentiation involved in lung developmentGO:06091510.1FGFR2, FGF10
2branch elongation involved in salivary gland morphogenesisGO:06066710.1FGFR2, FGF10
3mammary gland bud formationGO:06061510.0FGFR2, FGF10
4fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.0FGFR2, FGF10
5lacrimal gland developmentGO:03280810.0FGFR2, FGF10
6epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.0FGF10, FGFR2
7otic vesicle formationGO:03091610.0FGFR2, FGF10
8limb bud formationGO:06017410.0FGF10, FGFR2
9regulation of smoothened signaling pathwayGO:0085899.9FGF10, FGFR2
10embryonic digestive tract morphogenesisGO:0485579.9FGF10, FGFR2
11secretion by lung epithelial cell involved in lung growthGO:0610339.9FGF10, FGF7
12embryonic pattern specificationGO:0098809.8FGF10, FGFR2
13regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8FGF10, FGF7
14positive regulation of keratinocyte migrationGO:0515499.8FGF10, FGF7
15positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.8FGFR2, FGF7
16positive regulation of keratinocyte proliferationGO:0108389.8FGF10, FGF7
17branching involved in salivary gland morphogenesisGO:0604459.7FGF7, FGFR2
18protein localization to cell surfaceGO:0343949.7FGF7, FGF10
19positive chemotaxisGO:0509189.5FGF7, FGF10
20actin cytoskeleton reorganizationGO:0315329.5FGF7, FGF10
21hair follicle morphogenesisGO:0310699.4FGFR2, FGF10, FGF7
22positive regulation of epithelial cell proliferationGO:0506799.4FGFR2, FGF10, FGF7
23insulin receptor signaling pathwayGO:0082869.3FGFR2, FGF10, FGF7
24fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR2, FGF10, FGF7
25Fc-epsilon receptor signaling pathwayGO:0380959.1FGF7, FGF10, FGFR2
26angiogenesisGO:0015259.0KRIT1, FGF10, FGFR2
27epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR2, FGF10, FGF7
28phosphatidylinositol-mediated signalingGO:0480158.6FGF7, FGF10, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor bindingGO:0051049.5FGF7, FGF10
2chemoattractant activityGO:0420569.2FGF7, FGF10
3heparin bindingGO:0082019.0FGF7, FGF10, FGFR2

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet