MCID: ACN010
MIFTS: 38

Acanthoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Acanthoma

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Aliases & Descriptions for Acanthoma:

Name: Acanthoma 10 45 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:174
MeSH36 D049309
NCIt42 C7419

Summaries for Acanthoma

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NIH Rare Diseases:45 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary: Acanthoma is related to pilar sheath acanthoma and muir-torre syndrome. An important gene associated with Acanthoma is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways are DNA damage_Role of Brca1 and Brca2 in DNA repair and Colorectal Cancer Metastasis. Affiliated tissues include skin, ovary and testes, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Wikipedia:68 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

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Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1pilar sheath acanthoma30.4KRT10, KRT14, KRT5, KRT7, PTGER4
2muir-torre syndrome30.3MLH1, MSH2, MSH6, PMS2
3cellulitis29.3IFNA1, KRT5, KRT7, MLH1, MSH2, MSH6
4clear cell acanthoma11.0
5epidermolytic acanthoma10.7
6large cell acanthoma10.7
7acantholytic acanthoma10.5
8keratosis10.4
9psoriasis10.3
10gonorrhea10.3MLH1, MSH2
11anaplastic large cell lymphoma10.3MLH1, MSH2
12apert syndrome10.3FGF10, FGF7, FGFR2
13pfeiffer syndrome10.3FGF10, FGF7, FGFR2
14pili torti10.3KRT10, KRT14
15keratoconjunctivitis10.2KRT10, MLH1, MSH2
16encephalitozoonosis10.2KRT10, KRT14, PTGER4
17cholesterol embolism10.2FGFR2, KRT10, KRT14
18epm2a-related lafora disease10.2KRT14, KRT5
19auditory system cancer10.2MLH1, MSH2
20epidermolysis bullosa simplex, recessive 110.2KRT14, KRT5
21epidermolysis bullosa simplex-mp10.2KRT14, KRT5
22benign perivascular tumor10.2KRT5, PTGER4
23familial congenital fourth cranial nerve palsy10.2MLH1, MSH2
24pancreatic serous cystadenoma10.2MLH1, MSH2, MSH6
25nephrogenic adenoma10.2FGF10, FGFR2, SOX9
26lichen planus pemphigoides10.2KRT14, KRT5
27epidermodysplasia verruciformis10.2
28onychocytic matricoma10.2
29epidermolysis bullosa simplex, weber-cockayne type10.2KRT14, KRT5
30small non-cleaved cell lymphoma10.2MLH1, MSH2, MSH6
31anal margin basal cell carcinoma10.2CLEC2A, KRT14
32hallucinogen dependence10.1KRT10, KRT14, KRT5
33epidermolysis bullosa simplex, dowling-meara type10.1KRT10, KRT14, KRT5
34colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.1KRT10, KRT14, KRT5
35atypical mole syndrome10.1MSH2, MSH6
36vulvar nodular hidradenoma10.1CLEC2A, KRT10, PTGER4
37female reproductive system disease10.1MLH1, MSH2, MSH6
38neurofibromatosis, familial spinal10.1MLH1, MSH6, PMS2
39brugada syndrome10.1KRT10, KRT14, KRT5
40axillary adenitis10.1KRT10, KRT14, KRT5
41cloacogenic carcinoma10.1KRT7, PTGER4
42doyne honeycomb degeneration of retina10.1MLH1, MSH2, MSH6, PMS2
43sarcomatosis of the meninges10.1MLH1, MSH2, MSH6, PMS2
44peritonitis10.1KRT5, PTGER4
45nipah virus disease10.1MLH1, MSH2, MSH6, PMS2
46hereditary congenital ptosis10.1MLH1, MSH2, MSH6, PMS2
47smallpox10.1MLH1, MSH2, MSH6, PMS2
48mismatch repair cancer syndrome10.0MLH1, MSH2, MSH6, PMS2
49large intestine lipoma10.0MLH1, MSH2, MSH6, PMS2
50keratosis, seborrheic, somatic10.0CLEC2A, KRT10, KRT5

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Interventional clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

33
Skin, Ovary, Testes, Uterus

Animal Models for Acanthoma or affiliated genes

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MGI Mouse Phenotypes related to Acanthoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7CREB3L2, FGF10, FGFR2, KRT10, KRT5, MIB1
2MP:00020068.4FGFR2, KRT10, KRT14, MLH1, MSH2, MSH6
3MP:00053828.4CREB3L2, FGF10, FGFR2, KRT10, KRT14, KRT5
4MP:00053817.5CREB3L2, FGF10, FGFR2, IL2RA, KRT14, KRT5
5MP:00053977.4CABIN1, FGF10, FGF7, FGFR2, IL2RA, KRT14
6MP:00053847.3FGF10, FGFR2, KRT14, KRT7, MIB1, MLH1
7MP:00107717.2FGF10, FGF7, FGFR2, KRT10, KRT14, KRT5
8MP:00053877.2CABIN1, FGF10, FGF7, FGFR2, IL2RA, KRT10
9MP:00053767.2FGF10, FGF7, FGFR2, HPD, KRT14, MIB1
10MP:00107686.2CABIN1, CREB3L2, FGF10, FGFR2, IL2RA, KRT10

Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? (26512188)
2015
2
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. (25267214)
2014
3
Multiple clear cell acanthoma associated with multiple Bowen's disease. (24898560)
2014
4
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. (24750337)
2014
5
Multiple pigmented clear cell acanthoma in an African patient. (25414053)
2014
6
An unusual location of a pilar sheath acanthoma. (25368479)
2014
7
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. (25495637)
2014
8
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
9
A shiny red papule in an older person. Clear cell acanthoma. (23944729)
2013
10
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
11
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
12
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
13
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
14
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
15
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
16
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
17
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
18
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
19
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. (17214854)
2007
20
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
21
Clear cell acanthoma successfully treated with a carbon dioxide laser. (16188196)
2005
22
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
23
Polypoid clear cell acanthoma: case report. (11444278)
2000
24
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
25
Epidermolytic acanthomas: clinical characteristics and immunohistochemical features. (9185908)
1997
26
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
27
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
28
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
29
Etretinate therapy of solar-related kerato acanthoma. (8240190)
1993
30
Melanocytes in clear cell acanthoma. (1928630)
1991
31
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
32
Achromic verrucous large cell acanthoma. (2373780)
1990
33
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
34
Large cell acanthoma. A cytologic variant of Bowen's disease? (3232750)
1988
35
Acantholytic acanthoma. (2461398)
1988
36
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. (3743846)
1986
37
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
38
Disseminated epidermolytic acanthoma. (500873)
1979
39
Pilar sheath acanthoma. (718186)
1978
40
Squamous acanthoma of the oral mucosa. (4530964)
1974
41
Some evidence concerning the sweat duct origin of clear cell acanthoma. (4129605)
1973
42
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. (5413257)
1970
43
The ultrastructure of the pale cell acanthoma. (5774898)
1969
44
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
45
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
46
Adeno-acanthoma of the uterus. (14407697)
1959
47
Kerato-acanthoma; a lesion simulating carcinoma of skin. (13374633)
1956
48
Kerato-acanthoma. (13189828)
1954
49
Uterine adeno-acanthoma with metastasis; report of a case. (13214679)
1954
50
Molluscum sebaceum kerato-acanthoma, benign epithelioma. (12997614)
1952

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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GO Terms for genes affiliated with Acanthoma

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Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MutSalpha complexGO:003230110.2MSH2, MSH6
2MutLalpha complexGO:00323899.9MLH1, PMS2
3keratin filamentGO:00450958.8KRT10, KRT14, KRT5, KRT7
4intermediate filamentGO:00058828.5KRT10, KRT14, KRT5, KRT7

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1Harderian gland developmentGO:007038410.8FGF10, SOX9
2fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.8FGF10, FGFR2
3mammary gland bud formationGO:006061510.8FGF10, FGFR2
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.8FGF10, FGFR2
5branch elongation involved in salivary gland morphogenesisGO:006066710.8FGF10, FGFR2
6mesenchymal cell differentiation involved in lung developmentGO:006091510.8FGF10, FGFR2
7prostate gland morphogenesisGO:006051210.7FGFR2, SOX9
8organ growthGO:003526510.7FGF10, FGFR2
9somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.7MLH1, MSH2
10bud elongation involved in lung branchingGO:006044910.7FGF10, FGFR2
11epidermis morphogenesisGO:004873010.6FGF10, FGFR2
12regulation of epithelial cell proliferationGO:005067810.6FGF10, FGFR2
13meiotic mismatch repairGO:000071010.6MSH2, MSH6
14secretion by lung epithelial cell involved in lung growthGO:006103310.6FGF10, FGF7
15positive regulation of helicase activityGO:005109610.6MSH2, MSH6
16epithelial cell proliferationGO:005067310.6FGF10, FGFR2
17negative regulation of DNA recombinationGO:004591010.5MSH2, MSH6
18positive regulation of keratinocyte migrationGO:005154910.5FGF10, FGF7
19regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:006066510.5FGF10, FGF7
20lacrimal gland developmentGO:003280810.5FGF10, FGFR2, SOX9
21maintenance of DNA repeat elementsGO:004357010.5MSH2, MSH6
22positive regulation of keratinocyte proliferationGO:001083810.4FGF10, FGF7
23determination of adult lifespanGO:000834010.4MSH2, MSH6
24otic vesicle formationGO:003091610.3FGF10, FGFR2, SOX9
25positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:006050110.3FGF7, FGFR2
26ERK1 and ERK2 cascadeGO:007037110.3FGF10, PTGER4, SOX9
27epithelial tube branching involved in lung morphogenesisGO:006044110.3FGF10, FGFR2, SOX9
28hemidesmosome assemblyGO:003158110.2KRT14, KRT5
29branching involved in salivary gland morphogenesisGO:006044510.2FGF10, FGF7, FGFR2
30isotype switchingGO:004519010.1MLH1, MSH2, MSH6
31hair follicle morphogenesisGO:003106910.1FGF10, FGF7, FGFR2
32intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.1MLH1, MSH2, MSH6
33somatic recombination of immunoglobulin gene segmentsGO:001644710.0MLH1, MSH2, MSH6, PMS2
34reciprocal meiotic recombinationGO:000713110.0MLH1, MSH2, MSH6
35lung developmentGO:003032410.0FGF10, FGF7, FGFR2
36somatic hypermutation of immunoglobulin genesGO:001644610.0MLH1, MSH2, MSH6, PMS2
37positive regulation of epithelial cell proliferationGO:00506799.9FGF10, FGF7, FGFR2, SOX9
38mismatch repairGO:00062989.9MLH1, MSH2, MSH6, PMS2
39limb bud formationGO:00601749.9FGF10, FGFR2, SOX9
40epidermis developmentGO:00085449.6FGF10, FGF7, KRT14, KRT5
41MAPK cascadeGO:00001659.5FGF10, FGF7, FGFR2, IL2RA
42activation of MAPKK activityGO:00001869.5FGF10, FGF7, FGFR2, IL2RA
43epithelial cell differentiationGO:00308559.5FGF10, FGFR2, KRT10, KRT14
44Ras protein signal transductionGO:00072659.5FGF10, FGF7, FGFR2, IL2RA
45fibroblast growth factor receptor signaling pathwayGO:00085439.4FGF10, FGF7, FGFR2, IL2RA
46vascular endothelial growth factor receptor signaling pathwayGO:00480109.3FGF10, FGF7, FGFR2, IL2RA
47epidermal growth factor receptor signaling pathwayGO:00071738.8FGF10, FGF7, FGFR2, IL2RA, SOX9

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:003240710.5MLH1, PMS2
2guanine/thymine mispair bindingGO:003213710.4MSH2, MSH6
3single guanine insertion bindingGO:003214210.4MSH2, MSH6
4single thymine insertion bindingGO:003214310.4MSH2, MSH6
5type 2 fibroblast growth factor receptor bindingGO:000511110.4FGF10, FGF7
6oxidized purine DNA bindingGO:003235710.4MSH2, MSH6
7MutLalpha complex bindingGO:003240510.4MSH2, MSH6
8four-way junction DNA bindingGO:00004009.9MSH2, MSH6
9mismatched DNA bindingGO:00309839.8MLH1, MSH2, MSH6, PMS2
10single-stranded DNA bindingGO:00036979.7MLH1, MSH2, PMS2
11ATPase activityGO:00168879.3MLH1, MSH2, MSH6, PMS2
12structural molecule activityGO:00051988.9KRT10, KRT14, KRT5, KRT7

Sources for Acanthoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet