MCID: ACN010
MIFTS: 29

Acanthoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

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Aliases & Descriptions for Acanthoma:

Name: Acanthoma 11 46 13 66

Classifications:



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Disease Ontology11 DOID:174
MeSH37 D049309
NCIt43 C7419

Summaries for Acanthoma

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NIH Rare Diseases:46 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma, and has symptoms including leser-trélat sign An important gene associated with Acanthoma is FGFR2 (Fibroblast Growth Factor Receptor 2). Affiliated tissues include skin, ovary and testes.

Wikipedia:69 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

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Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms for Acanthoma

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UMLS symptoms related to Acanthoma:


leser-trélat sign

Drugs & Therapeutics for Acanthoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

34
Skin, Ovary, Testes, Uterus

Animal Models for Acanthoma or affiliated genes

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Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. (27185430)
2016
2
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. (26825163)
2016
3
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. (25267214)
2014
4
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. (24750337)
2014
5
Clear cell acanthoma of the nipple: another report from Italy. (24626678)
2014
6
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
7
Acanthoma fissuratum on the penis. (21913907)
2013
8
Solitary epidermolytic acanthoma. (23710687)
2013
9
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
10
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
11
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
12
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
13
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? (21317609)
2011
14
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
15
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). (20500186)
2010
16
Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome. (19461247)
2009
17
Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma. (19397663)
2009
18
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
19
Acantholytic acanthoma clinically resembling a molluscum contagiosum. (17207187)
2007
20
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
21
Reticulated acanthoma with sebaceous differentiation. (16625081)
2006
22
Clear cell acanthoma occurring in a split-thickness skin graft. (16327592)
2005
23
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. (14721785)
2003
24
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
25
Polypoid clear cell acanthoma: case report. (11444278)
2000
26
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
27
Disseminated epidermolytic acanthoma probably related to trauma. (10583127)
1999
28
Clear cell acanthoma developing in epidermal nevus. (9350108)
1997
29
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
30
Cystic clear cell acanthoma. (7560357)
1995
31
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
32
Disseminated eruptive clear cell acanthoma--a case report with review of the literature. (8033390)
1994
33
Disseminated epidermolytic acanthoma. (8434736)
1993
34
Epidermolytic acanthoma does not contain human papillomavirus DNA. (1649846)
1991
35
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
36
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
37
Acanthoma induction in psoriasis patients after short-term high potency Goeckerman treatment. (7307574)
1981
38
Multiple kerato-acanthoma: a case report. (6162321)
1980
39
Acanthoma fissuratum. Histopathology and review of the literature. (477393)
1979
40
Pilar sheath acanthoma. (718186)
1978
41
Acanthoma fissuratum--spectacle frame acanthoma. (55043)
1975
42
Squamous acanthoma of the oral mucosa. (4530964)
1974
43
Clear cell acanthoma: clinicopathologic analysis of 37 new cases. (4687348)
1973
44
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
45
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
46
Clinical recognition of clear-cell acanthoma (Degos'). (5350407)
1969
47
Degos' acanthoma (acanthome a cellules claires). A clinical and histological report of nine cases. (4143668)
1966
48
Adeno-acanthoma of the uterus. (14407697)
1959
49
Kerato-acanthoma. (13189828)
1954
50
Primary and secondary ovarian adeno-acanthoma. (13205409)
1954

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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GO Terms for genes affiliated with Acanthoma

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Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.0KRT10, KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1mammary gland bud formationGO:006061510.2FGF10, FGFR2
2mesenchymal cell differentiation involved in lung developmentGO:006091510.2FGF10, FGFR2
3branch elongation involved in salivary gland morphogenesisGO:006066710.2FGF10, FGFR2
4fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.2FGF10, FGFR2
5lacrimal gland developmentGO:003280810.2FGF10, FGFR2
6embryonic digestive tract morphogenesisGO:004855710.1FGF10, FGFR2
7epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.1FGF10, FGFR2
8phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.1FGF10, FGFR2
9bud elongation involved in lung branchingGO:006044910.1FGF10, FGFR2
10phosphatidylinositol phosphorylationGO:004685410.0FGF10, FGFR2
11epidermis morphogenesisGO:004873010.0FGF10, FGFR2
12regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0FGF10, FGFR2
13otic vesicle formationGO:003091610.0FGF10, FGFR2
14lung alveolus developmentGO:004828610.0FGF10, FGFR2
15limb bud formationGO:006017410.0FGF10, FGFR2
16phosphatidylinositol-mediated signalingGO:00480159.9FGF10, FGFR2
17regulation of smoothened signaling pathwayGO:00085899.9FGF10, FGFR2
18fibroblast growth factor receptor signaling pathwayGO:00085439.9FGF10, FGFR2
19branching involved in salivary gland morphogenesisGO:00604459.9FGF10, FGFR2
20hair follicle morphogenesisGO:00310699.9FGF10, FGFR2
21digestive tract developmentGO:00485659.9FGF10, FGFR2
22animal organ morphogenesisGO:00098879.8FGF10, FGFR2
23organ growthGO:00352659.8FGF10, FGFR2
24lung developmentGO:00303249.8FGF10, FGFR2
25positive regulation of Wnt signaling pathwayGO:00301779.7FGF10, FGFR2
26embryonic pattern specificationGO:00098809.7FGF10, FGFR2
27positive regulation of MAPK cascadeGO:00434109.7FGF10, FGFR2
28positive regulation of canonical Wnt signaling pathwayGO:00902639.7FGF10, FGFR2
29epidermis developmentGO:00085449.5FGF10, KRT9
30epithelial cell differentiationGO:00308559.5FGF10, FGFR2
31inner ear morphogenesisGO:00424729.4FGF10, FGFR2
32positive regulation of epithelial cell proliferationGO:00506799.2FGF10, FGFR2

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:00163039.9FGF10, FGFR2
2phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.8FGF10, FGFR2
3Ras guanyl-nucleotide exchange factor activityGO:00050889.5FGF10, FGFR2
4protein tyrosine kinase activityGO:00047139.2FGF10, FGFR2

Sources for Acanthoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet