Aliases & Classifications for Acanthoma

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Acanthoma, Aliases & Descriptions:

Name: Acanthoma 9 41 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:174
NCIt38 C7419
MeSH33 D049309

Summaries for Acanthoma

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NIH Rare Diseases:41 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and FGFR ligand binding and activation. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are craniofacial and integument.

Wikipedia:63 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

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Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma32.2IVL
2epidermolytic acanthoma31.8KRT1
3keratosis30.3IVL, CLEC2A, KRT10, KRT1, KRT16
4basal cell carcinoma30.2KRT16, KRT10, IVL
5keratoacanthoma29.9KRT10, PCNA, IVL
6papilloma29.9KRT10, PCNA, IVL
7psoriasis29.8IVL, KRT10, KRT1, KRT16, KRIT1, FGF7
8large cell acanthoma10.6
9pilar sheath acanthoma10.5
10acantholytic acanthoma10.5
11monilethrix10.5KRT16
12hailey-hailey disease10.4IVL
13syringocystadenoma papilliferum10.4CLEC2A
14steatocystoma multiplex10.3KRT10, KRT16
15ichthyosis, cyclic, with epidermolytic hyperkeratosis10.3KRT10, KRT1
16epidermolytic hyperkeratosis10.3KRT10, KRT1
17palmoplantar keratoderma, epidermolytic10.3KRT1, KRT16
18keratoderma10.3KRT16, KRT1
19fibroma10.3IVL, KRT1
20ichthyosis lamellar 110.3IVL, KRT10
21actinic keratosis10.3PCNA
22cervical squamous cell carcinoma10.2IVL, KRT10
23cervical intraepithelial neoplasia10.2IVL, KRT10
24palmoplantar keratosis10.2KRT10, KRT1, KRT16
25palmoplantar keratoderma, nonepidermolytic10.2KRT16, KRT1, KRT10
26congenital ichthyosiform erythroderma10.1IVL, KRT10, KRT1
27muir-torre syndrome10.1
28cellulitis10.1
29onychocytic matricoma10.1
30pfeiffer syndrome10.1FGF7, FGFR2
31apert syndrome10.1FGF7, FGFR2
32dermatitis10.1KRT16, IVL
33oral leukoplakia10.1KRT1, PCNA
34ameloblastoma10.1KRT1, PCNA
35middle ear cholesteatoma10.0IVL, PCNA
36smooth muscle tumor10.0PCNA, IVL
37mucoepidermoid carcinoma10.0PCNA, IVL
38epidermolysis bullosa simplex10.0IVL, KRT10, KRT1, KRT16
39lichen planus10.0KRT16, KRT1, KRT10, IVL
40epidermodysplasia verruciformis10.0
41molluscum contagiosum10.0
42adenoiditis10.0
43porokeratosis10.0
44endometriosis10.0
45inverted follicular keratosis10.0
46trichofolliculoma10.0
47warty dyskeratoma10.0
48leukoplakia9.9IVL, PCNA, KRT1
49grade iii astrocytoma9.9FGFR2, PCNA
50leiomyoma9.9PCNA, CLEC2A, IVL

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Drug clinical trials:

Search ClinicalTrials for Acanthoma

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

31
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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MGI Mouse Phenotypes related to Acanthoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8KRT10, KRT16, KRIT1, FGFR2
2MP:00107718.4FGF7, FGFR2, KRT16, KRT1, KRT10
3MP:00053877.9FGF7, FGFR2, KRT1, KRT10, PCNA
4MP:00107687.4PCNA, KRT10, KRT1, KRT16, KRIT1, FGFR2

Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. (25267214)
2014
2
Multiple clear cell acanthoma associated with multiple Bowen's disease. (24898560)
2014
3
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. (24750337)
2014
4
Multiple pigmented clear cell acanthoma in an African patient. (25414053)
2014
5
An unusual location of a pilar sheath acanthoma. (25368479)
2014
6
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. (25495637)
2014
7
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
8
A shiny red papule in an older person. Clear cell acanthoma. (23944729)
2013
9
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
10
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
11
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
12
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
13
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
14
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
15
Postauricular pilar sheath acanthoma. (21769237)
2011
16
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
17
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
18
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
19
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
20
Clear cell acanthoma successfully treated with a carbon dioxide laser. (16188196)
2005
21
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
22
Polypoid clear cell acanthoma: case report. (11444278)
2000
23
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
24
Epidermolytic acanthomas: clinical characteristics and immunohistochemical features. (9185908)
1997
25
Clear cell acanthoma developing in epidermal nevus. (9350108)
1997
26
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
27
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
28
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
29
Etretinate therapy of solar-related kerato acanthoma. (8240190)
1993
30
Melanocytes in clear cell acanthoma. (1928630)
1991
31
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
32
Achromic verrucous large cell acanthoma. (2373780)
1990
33
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
34
Large cell acanthoma. A cytologic variant of Bowen's disease? (3232750)
1988
35
Acantholytic acanthoma. (2461398)
1988
36
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. (3743846)
1986
37
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
38
Disseminated epidermolytic acanthoma. (500873)
1979
39
Pilar sheath acanthoma. (718186)
1978
40
Squamous acanthoma of the oral mucosa. (4530964)
1974
41
Some evidence concerning the sweat duct origin of clear cell acanthoma. (4129605)
1973
42
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. (5413257)
1970
43
The ultrastructure of the pale cell acanthoma. (5774898)
1969
44
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
45
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
46
Adeno-acanthoma of the uterus. (14407697)
1959
47
Kerato-acanthoma; a lesion simulating carcinoma of skin. (13374633)
1956
48
Kerato-acanthoma. (13189828)
1954
49
Uterine adeno-acanthoma with metastasis; report of a case. (13214679)
1954
50
Molluscum sebaceum kerato-acanthoma, benign epithelioma. (12997614)
1952

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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Compounds for genes affiliated with Acanthoma

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Compounds related to Acanthoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1tazarotene43 1211.0KRT1, KRT10
2isotretinoin43 1210.9KRT10, KRT1, KRT16
3palifermin43 1210.7FGF7, FGFR2
4dithranol439.7KRT16, KRT10, IVL
5calcipotriol43 59 28 1212.7KRT16, KRT10, IVL
6eosin439.7KRT10, PCNA
7sodium dodecylsulfate439.6IVL, KRT1, KRT16
8gf 109203x43 5910.5KRIT1, KRT10, IVL
9selenomethionine43 2410.5KRIT1, PCNA
10pimonidazole439.4IVL, PCNA
11retinoid439.3KRT16, KRT1, KRT10, IVL
12calcitriol43 59 24 1212.3IVL, KRT10, KRT16
13chondroitin sulfate43 2410.2FGF7, FGFR2, IVL
141,25 dihydroxy vitamin d3439.1IVL, KRT10, KRT16, FGF7
15heparan sulfate43 2410.1IVL, FGFR2, FGF7
16vitamin d438.9IVL, KRT10, FGFR2, FGF7
17phenylalanine438.9KRT1, KRIT1, FGFR2
18nicotine43 28 49 1211.9KRT1, PCNA, IVL
1912-o-tetradecanoylphorbol 13-acetate438.9IVL, KRT1, FGFR2, FGF7
20proline438.9IVL, KRT10, KRT1, KRT16, FGFR2
21hematoxylin438.9IVL, PCNA, KRT10, KRT1
22thapsigargin43 599.8IVL, PCNA, KRIT1
23cyclophosphamide43 49 1210.8PCNA, FGFR2, FGF7
24adenylate438.7IVL, KRIT1, FGFR2, FGF7
25nitric oxide43 24 1210.6FGF7, FGFR2, KRIT1, KRT16
26tamoxifen43 49 28 1211.6PCNA, KRIT1, FGFR2, FGF7
27aspartate438.5PCNA, KRT1, KRIT1, FGF7
28genistein43 28 59 2 24 1213.5PCNA, KRIT1, FGFR2, FGF7
29arginine438.5PCNA, KRT10, KRT1, KRIT1, FGFR2
30glutamate438.5PCNA, KRT10, KRT1, KRIT1, FGFR2
315fluorouracil438.5IVL, PCNA, FGFR2, FGF7
32cyclosporin a43 28 5910.5IVL, PCNA, KRIT1, FGF7
33glutamine438.4IVL, PCNA, KRIT1, FGF7
34h2o2438.4PCNA, KRIT1, FGFR2, FGF7
35thymidine43 249.4FGF7, FGFR2, PCNA, IVL
36progesterone43 28 59 24 1212.3FGF7, FGFR2, KRT1, KRT10, PCNA
37steroid438.3IVL, KRT10, KRT1, KRT16, FGFR2, FGF7
38testosterone43 59 24 1211.2PCNA, KRT1, KRIT1, FGFR2, FGF7
39dexamethasone43 49 28 1211.2IVL, PCNA, KRT10, KRIT1, FGF7
40tyrosine438.1IVL, KRT10, KRT1, KRIT1, FGFR2, FGF7
41oligonucleotide438.1FGF7, FGFR2, PCNA, IVL
42suramin43 28 1210.1IVL, PCNA, KRIT1, FGFR2, FGF7
43paraffin438.1IVL, PCNA, KRT10, KRT1, KRT16, FGFR2
44calcium43 49 24 1211.1IVL, KRT10, KRT1, KRIT1, FGFR2, FGF7
45cysteine438.0IVL, PCNA, KRIT1, FGFR2, FGF7
46vegf438.0FGF7, FGFR2, PCNA, IVL
47serine437.9IVL, KRT10, KRT1, KRT16, KRIT1, FGFR2
48bromodeoxyuridine437.8FGF7, FGFR2, KRT1, KRT10, PCNA, IVL
49retinoic acid43 248.5IVL, PCNA, KRT10, KRT1, KRT16, FGFR2
50estrogen437.4IVL, PCNA, KRT10, KRT1, KRIT1, FGFR2

GO Terms for genes affiliated with Acanthoma

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Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.1KRT16, KRT1, KRT10, PCNA, IVL

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:00302169.6KRT10, IVL
2positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:00605019.6FGF7, FGFR2
3branching involved in salivary gland morphogenesisGO:00604459.5FGFR2, FGF7
4hair follicle morphogenesisGO:00310699.5FGF7, FGFR2
5epidermis developmentGO:00085449.5FGF7, KRT16
6positive regulation of cell divisionGO:00517819.5FGFR2, FGF7
7positive regulation of epithelial cell proliferationGO:00506799.3FGF7, FGFR2
8epithelial cell differentiationGO:00308558.9FGFR2, PCNA
9phosphatidylinositol-mediated signalingGO:00480158.8FGF7, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.9FGF7, FGFR2, KRIT1, KRT16, KRT1, PCNA

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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