MCID: ACN010
MIFTS: 30

Acanthoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 50 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 42 D049309
NCIt 47 C7419
UMLS 69 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 50 an acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary : Acanthoma is related to squamous cell carcinoma and clear cell acanthoma. An important gene associated with Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes.

Wikipedia : 72 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 26.6 FGF10 FGFR2 HPD KRT1 KRT10 KRT9
2 clear cell acanthoma 12.3
3 epidermolytic acanthoma 12.2
4 large cell acanthoma 12.2
5 pilar sheath acanthoma 12.2
6 acantholytic acanthoma 11.9
7 onychocytic matricoma 10.9
8 partial of retinal vein occlusion 10.2 FGF10 FGFR2
9 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.2 FGF10 FGFR2
10 bladder cancer, somatic 10.2 FGF10 FGFR2
11 andersen syndrome 10.1 KRT1 KRT10
12 thanatophoric dysplasia, type ii 10.1 FGF10 FGFR2
13 ichthyosis histrix, curth-macklin type 10.1 KRT1 KRT10
14 idiopathic neonatal atrial flutter 10.1 KRT1 KRT10
15 uremic neuropathy 10.1 KRT1 KRT10
16 keratosis 10.1
17 basal cell carcinoma 4 10.0 KRT1 KRT9
18 keratosis palmoplantaris striata iii 10.0 KRT1 KRT9
19 palmoplantar keratoderma, epidermolytic 10.0 KRT1 KRT9
20 tooth disease 10.0 FGF10 FGFR2
21 psoriasis 9.9
22 neuropathy 9.9 FGFR2 KRT10
23 palmoplantar keratoderma, nonepidermolytic, focal 9.9 KRT10 KRT9
24 retinitis pigmentosa 30 9.9 KRT1 KRT10
25 jackson-weiss syndrome 9.9 FGF10 FGFR2
26 bilateral retinoblastoma 9.8 KRT1 KRT10
27 cellulitis 9.8
28 muir-torre syndrome 9.8
29 epidermodysplasia verruciformis 9.8
30 bowen's disease 9.8
31 papilloma 9.6
32 warty dyskeratoma 9.6
33 endometriosis 9.6
34 keratoacanthoma 9.6
35 porokeratosis 9.6
36 adenoiditis 9.6
37 inverted follicular keratosis 9.6
38 bullous pemphigoid 9.6
39 ichthyosis 9.6
40 molluscum contagiosum 9.6
41 melanoma 9.6
42 basal cell carcinoma 9.6
43 trichofolliculoma 9.6
44 marburg hemorrhagic fever 9.6 KRT1 KRT10 KRT9
45 bamforth-lazarus syndrome 9.6 KRT1 KRT10 KRT9
46 epidermolysis bullosa simplex, dowling-meara type 9.5 KRT1 KRT10 KRT9
47 carotid artery disease 9.5 KRT1 KRT10 KRT9
48 telangiectasia, hereditary hemorrhagic, type 2 9.5 KRT1 KRT10 KRT9
49 ichthyosis, cyclic, with epidermolytic hyperkeratosis 9.5 KRT1 KRT10 KRT9
50 breast leiomyoma 9.5 KRT1 KRT10 KRT9

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

39
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 223)
id Title Authors Year
1
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
2
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
3
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
4
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
5
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2017
6
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2017
7
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
8
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
9
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. ( 28007675 )
2016
10
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
11
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
12
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
13
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
14
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
15
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
16
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
17
Porokeratotic acanthoma. ( 25631132 )
2015
18
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
19
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
20
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
21
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
22
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
23
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
24
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014
25
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
26
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
27
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
28
An unusual location of a pilar sheath acanthoma. ( 25368479 )
2014
29
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
30
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
31
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
32
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
33
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
34
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
35
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
36
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2014
37
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
38
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
39
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
40
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. ( 23083445 )
2013
41
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
42
Solitary epidermolytic acanthoma. ( 23710687 )
2013
43
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? ( 23651324 )
2013
44
Clear cell acanthoma. ( 24087787 )
2013
45
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
46
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ( 23786782 )
2013
47
Acanthoma fissuratum on the penis. ( 21913907 )
2013
48
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
49
Clear cell acanthoma. ( 23171155 )
2012
50
Rare persistent kerato-acanthoma of left lower eyelid: a case report. ( 23029833 )
2012

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 FGF10 FGFR2 KRT1 KRT10 KRT9
2
Show member pathways
11.59 KRT1 KRT10 KRT9

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.16 KRT1 KRT10
2 extracellular matrix GO:0031012 9.13 FGF10 FGFR2 KRT1
3 intermediate filament GO:0005882 8.8 KRT1 KRT10 KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.73 KRT1 KRT10 KRT9
2 phosphatidylinositol phosphorylation GO:0046854 9.66 FGF10 FGFR2
3 lung development GO:0030324 9.65 FGF10 FGFR2
4 wound healing GO:0042060 9.65 FGF10 FGFR2
5 positive regulation of MAPK cascade GO:0043410 9.65 FGF10 FGFR2
6 cornification GO:0070268 9.65 KRT1 KRT10 KRT9
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.64 FGF10 FGFR2
8 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.64 FGF10 FGFR2
9 epithelial cell differentiation GO:0030855 9.63 FGF10 FGFR2
10 positive regulation of epithelial cell proliferation GO:0050679 9.63 FGF10 FGFR2
11 inner ear morphogenesis GO:0042472 9.62 FGF10 FGFR2
12 peptide cross-linking GO:0018149 9.62 KRT1 KRT10
13 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.61 FGF10 FGFR2
14 positive regulation of Wnt signaling pathway GO:0030177 9.61 FGF10 FGFR2
15 digestive tract development GO:0048565 9.6 FGF10 FGFR2
16 lung alveolus development GO:0048286 9.59 FGF10 FGFR2
17 embryonic pattern specification GO:0009880 9.58 FGF10 FGFR2
18 hair follicle morphogenesis GO:0031069 9.58 FGF10 FGFR2
19 regulation of smoothened signaling pathway GO:0008589 9.57 FGF10 FGFR2
20 embryonic digestive tract morphogenesis GO:0048557 9.55 FGF10 FGFR2
21 organ growth GO:0035265 9.54 FGF10 FGFR2
22 branching involved in salivary gland morphogenesis GO:0060445 9.52 FGF10 FGFR2
23 limb bud formation GO:0060174 9.51 FGF10 FGFR2
24 skin epidermis development GO:0098773 9.49 KRT1 KRT10
25 lacrimal gland development GO:0032808 9.46 FGF10 FGFR2
26 otic vesicle formation GO:0030916 9.43 FGF10 FGFR2
27 epidermis morphogenesis GO:0048730 9.4 FGF10 FGFR2
28 bud elongation involved in lung branching GO:0060449 9.37 FGF10 FGFR2
29 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.32 FGF10 FGFR2
30 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.26 FGF10 FGFR2
31 mammary gland bud formation GO:0060615 9.16 FGF10 FGFR2
32 mesenchymal cell differentiation involved in lung development GO:0060915 8.96 FGF10 FGFR2
33 branch elongation involved in salivary gland morphogenesis GO:0060667 8.62 FGF10 FGFR2

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF10 FGFR2
2 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF10 FGFR2
3 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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28 GO
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30 HGMD
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32 HPO
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34 ICD10 via Orphanet
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42 MeSH
43 MESH via Orphanet
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48 NDF-RT
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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