MCID: ACN010
MIFTS: 46

Acanthoma malady

Rare diseases, Cancer diseases categories

Summaries for Acanthoma

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NIH Rare Diseases:42 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and FGFR ligand binding and activation. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are craniofacial and integument.

Wikipedia:64 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

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Acanthoma, Aliases & Descriptions:

Name: Acanthoma 9 42 11 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:174
NCIt39 C7419
MeSH34 D049309

Related Diseases for Acanthoma

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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma32.1IVL
2epidermolytic acanthoma31.8KRT1
3keratosis30.3IVL, CLEC2A, KRT10, KRT1, KRT16
4basal cell carcinoma30.2KRT16, KRT10, IVL
5keratoacanthoma29.9KRT10, PCNA, IVL
6papilloma29.9KRT10, PCNA, IVL
7psoriasis29.8IVL, KRT10, KRT1, KRT16, KRIT1, FGF7
8large cell acanthoma10.6
9pilar sheath acanthoma10.5
10acantholytic acanthoma10.5
11monilethrix10.5KRT16
12hailey-hailey disease10.5IVL
13syringocystadenoma papilliferum10.4CLEC2A
14steatocystoma multiplex10.3KRT10, KRT16
15ichthyosis, cyclic, with epidermolytic hyperkeratosis10.3KRT10, KRT1
16epidermolytic hyperkeratosis10.3KRT10, KRT1
17palmoplantar keratoderma, epidermolytic10.3KRT1, KRT16
18keratoderma10.3KRT16, KRT1
19fibroma10.3IVL, KRT1
20ichthyosis lamellar 110.3IVL, KRT10
21actinic keratosis10.3PCNA
22cervical squamous cell carcinoma10.3IVL, KRT10
23cervical intraepithelial neoplasia10.2IVL, KRT10
24seborrheic keratosis10.2
25epidermal nevus10.2
26palmoplantar keratosis10.2KRT10, KRT1, KRT16
27nonepidermolytic palmoplantar keratoderma10.2KRT16, KRT1, KRT10
28congenital ichthyosiform erythroderma10.2IVL, KRT10, KRT1
29infectious mononucleosis10.1FGF7, FGFR2
30acrocephalosyndactylia10.1FGF7, FGFR2
31muir-torre syndrome10.1
32epidermodysplasia verruciformis10.1
33cellulitis10.1
34onychocytic matricoma10.1
35dermatitis10.1KRT16, IVL
36oral leukoplakia10.1KRT1, PCNA
37ameloblastoma10.1KRT1, PCNA
38middle ear cholesteatoma10.1IVL, PCNA
39smooth muscle tumor10.0PCNA, IVL
40mucoepidermoid carcinoma10.0PCNA, IVL
41epidermolysis bullosa simplex10.0IVL, KRT10, KRT1, KRT16
42lichen planus10.0KRT16, KRT1, KRT10, IVL
43inflamed seborrheic keratosis10.0
44adenoiditis10.0
45molluscum contagiosum10.0
46porokeratosis10.0
47endometriosis10.0
48inverted follicular keratosis10.0
49trichofolliculoma10.0
50warty dyskeratoma10.0

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Drug clinical trials:

Search ClinicalTrials for Acanthoma

Search NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

32
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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MGI Mouse Phenotypes related to Acanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8KRT10, KRT16, KRIT1, FGFR2
2MP:00107718.4FGF7, FGFR2, KRT16, KRT1, KRT10
3MP:00053877.9FGF7, FGFR2, KRT1, KRT10, PCNA
4MP:00107687.4PCNA, KRT10, KRT1, KRT16, KRIT1, FGFR2

Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50)    (show all 195)
idTitleAuthorsYear
1
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. (25267214)
2014
2
Multiple clear cell acanthoma associated with multiple Bowen's disease. (24898560)
2014
3
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. (24750337)
2014
4
An unusual location of a pilar sheath acanthoma. (25368479)
2014
5
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
6
A shiny red papule in an older person. Clear cell acanthoma. (23944729)
2013
7
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
8
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
9
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
10
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
11
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
12
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
13
Postauricular pilar sheath acanthoma. (21769237)
2011
14
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
15
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
16
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
17
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. (17214854)
2007
18
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
19
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. (14721785)
2003
20
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
21
Polypoid clear cell acanthoma: case report. (11444278)
2000
22
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
23
Disseminated epidermolytic acanthoma probably related to trauma. (10583127)
1999
24
Epidermolytic acanthomas: clinical characteristics and immunohistochemical features. (9185908)
1997
25
Clear cell acanthoma developing in epidermal nevus. (9350108)
1997
26
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
27
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
28
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
29
Etretinate therapy of solar-related kerato acanthoma. (8240190)
1993
30
Melanocytes in clear cell acanthoma. (1928630)
1991
31
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
32
Achromic verrucous large cell acanthoma. (2373780)
1990
33
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
34
Large cell acanthoma. A cytologic variant of Bowen's disease? (3232750)
1988
35
Acantholytic acanthoma. (2461398)
1988
36
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. (3743846)
1986
37
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
38
Disseminated epidermolytic acanthoma. (500873)
1979
39
Pilar sheath acanthoma. (718186)
1978
40
Some evidence concerning the sweat duct origin of clear cell acanthoma. (4129605)
1973
41
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. (5413257)
1970
42
The ultrastructure of the pale cell acanthoma. (5774898)
1969
43
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
44
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
45
Adeno-acanthoma of the uterus. (14407697)
1959
46
Kerato-acanthoma; a lesion simulating carcinoma of skin. (13374633)
1956
47
Kerato-acanthoma. (13189828)
1954
48
Uterine adeno-acanthoma with metastasis; report of a case. (13214679)
1954
49
Multiple acanthoma (tumor-like keratosis of Poth). (13091403)
1953
50
Molluscum sebaceum kerato-acanthoma, benign epithelioma. (12997614)
1952

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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Compounds for genes affiliated with Acanthoma

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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1tazarotene44 1211.0KRT1, KRT10
2isotretinoin44 1210.9KRT10, KRT1, KRT16
3palifermin44 1210.7FGFR2, FGF7
4dithranol449.7IVL, KRT16, KRT10
5calcipotriol44 60 29 1212.7IVL, KRT10, KRT16
6eosin449.7PCNA, KRT10
7sodium dodecylsulfate449.6IVL, KRT1, KRT16
8gf 109203x44 6010.5KRIT1, KRT10, IVL
9selenomethionine44 2510.5KRIT1, PCNA
10pimonidazole449.4IVL, PCNA
11retinoid449.3IVL, KRT16, KRT1, KRT10
12calcitriol44 60 25 1212.3KRT16, KRT10, IVL
13chondroitin sulfate44 2510.2FGFR2, IVL, FGF7
141,25 dihydroxy vitamin d3449.1IVL, KRT16, KRT10, FGF7
15heparan sulfate44 2510.1FGFR2, FGF7, IVL
16vitamin d448.9FGFR2, FGF7, KRT10, IVL
17phenylalanine448.9KRT1, FGFR2, KRIT1
18nicotine44 29 50 1211.9PCNA, KRT1, IVL
1912-o-tetradecanoylphorbol 13-acetate448.9IVL, KRT1, FGFR2, FGF7
20proline448.9IVL, FGFR2, KRT10, KRT16, KRT1
21hematoxylin448.9KRT1, KRT10, IVL, PCNA
22thapsigargin44 609.8PCNA, KRIT1, IVL
23cyclophosphamide44 50 1210.8PCNA, FGFR2, FGF7
24adenylate448.7KRIT1, FGFR2, FGF7, IVL
25nitric oxide44 25 1210.6KRIT1, FGFR2, KRT16, FGF7
26tamoxifen44 50 29 1211.6PCNA, KRIT1, FGFR2, FGF7
27aspartate448.5KRT1, FGF7, PCNA, KRIT1
28genistein44 29 60 3 25 1213.5PCNA, FGF7, FGFR2, KRIT1
29arginine448.5PCNA, KRT1, KRIT1, KRT10, FGFR2
30glutamate448.5FGFR2, KRIT1, KRT1, KRT10, PCNA
315fluorouracil448.5IVL, PCNA, FGFR2, FGF7
32cyclosporin a44 29 6010.5KRIT1, PCNA, IVL, FGF7
33glutamine448.4IVL, PCNA, KRIT1, FGF7
34h2o2448.4KRIT1, PCNA, FGF7, FGFR2
35thymidine44 259.4PCNA, FGF7, FGFR2, IVL
36progesterone44 29 60 25 1212.3FGF7, KRT10, PCNA, FGFR2, KRT1
37steroid448.3IVL, FGF7, FGFR2, KRT16, KRT1, KRT10
38testosterone44 60 25 1211.2KRIT1, FGFR2, FGF7, PCNA, KRT1
39dexamethasone44 50 29 1211.2IVL, PCNA, KRIT1, FGF7, KRT10
40tyrosine448.1FGF7, FGFR2, IVL, KRIT1, KRT1, KRT10
41oligonucleotide448.1IVL, FGF7, FGFR2, PCNA
42suramin44 29 1210.1KRIT1, IVL, PCNA, FGF7, FGFR2
43paraffin448.1FGFR2, KRT1, KRT10, PCNA, KRT16, IVL
44calcium44 50 25 1211.1KRT10, FGF7, KRIT1, FGFR2, KRT1, IVL
45cysteine448.0PCNA, FGFR2, KRIT1, FGF7, IVL
46vegf448.0PCNA, FGF7, IVL, FGFR2
47serine447.9FGF7, FGFR2, KRT10, KRIT1, IVL, KRT16
48bromodeoxyuridine447.8KRT1, FGF7, KRT10, PCNA, FGFR2, IVL
49retinoic acid44 258.5KRT16, FGFR2, KRT1, KRT10, PCNA, IVL
50estrogen447.4FGF7, FGFR2, KRIT1, KRT10, PCNA, IVL

GO Terms for genes affiliated with Acanthoma

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Cellular components related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1KRT16, KRT1, KRT10, PCNA, IVL

Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:0302169.6KRT10, IVL
2positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.6FGFR2, FGF7
3branching involved in salivary gland morphogenesisGO:0604459.5FGFR2, FGF7
4hair follicle morphogenesisGO:0310699.5FGF7, FGFR2
5epidermis developmentGO:0085449.5KRT16, FGF7
6positive regulation of cell divisionGO:0517819.5FGFR2, FGF7
7positive regulation of epithelial cell proliferationGO:0506799.3FGF7, FGFR2
8epithelial cell differentiationGO:0308558.9PCNA, FGFR2
9phosphatidylinositol-mediated signalingGO:0480158.8PCNA, FGFR2, FGF7

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9FGF7, FGFR2, KRIT1, KRT16, KRT1, PCNA

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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4CDC
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26ICD10
27ICD10 via Orphanet
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30KEGG
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40NDF-RT
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62UMLS via Orphanet