MCID: ACN010
MIFTS: 44

Acanthoma malady

Summaries for Acanthoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT1 (keratin 1), and among its related pathways are NF-KappaB Family Pathway and Fc epsilon receptor (FCERI) signaling. The compounds glutamate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are integument and craniofacial.

Wikipedia:63 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

acanthoma 8 42 10 60


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Disease Ontology8 DOID:174
MeSH34 D049309
NCIt39 C7419

Related Diseases for Acanthoma

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17GeneCards, 18GeneDecks
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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma31.3IVL
2epidermolytic acanthoma30.9KRT1
3keratosis30.4CLEC2A, KRT16, KRT1, KRT10, IVL
4psoriasis30.3KRT1, KRT10, KRIT1, KRT16, IVL, FGF7
5squamous cell carcinoma30.2IVL, PCNA, KRT10, FGFR2, KRT16, FGF7
6molluscum contagiosum29.8IVL
7keratoacanthoma29.8KRT10, PCNA, IVL
8papilloma29.8IVL, KRT10, PCNA
9large cell acanthoma10.5
10acantholytic acanthoma10.5
11pilar sheath acanthoma10.4
12seborrheic keratosis10.2
13cellulitis10.1
14muir-torre syndrome10.1
15epidermodysplasia verruciformis10.1
16onychocytic matricoma10.1
17syringoma10.0KRT1
18monilethrix10.0KRT16
19ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
20epidermolytic hyperkeratosis10.0KRT1, KRT10
21cervical intraepithelial neoplasia10.0KRT10, IVL
22acrocephalosyndactylia10.0FGFR2
23keratoderma10.0KRT16, KRT1
24palmoplantar keratoderma, epidermolytic10.0KRT16, KRT1
25steatocystoma multiplex10.0KRT16, KRT10
26congenital ichthyosiform erythroderma10.0KRT10, IVL
27sarcoma10.0FGF7
28palmoplantar keratosis10.0KRT16, KRT10, KRT1
29nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1, KRT16
30syringocystadenoma papilliferum10.0CLEC2A
31hidradenoma10.0CLEC2A
32oral leukoplakia10.0PCNA, KRT1
33alopecia10.0CLEC2A
34basal cell carcinoma10.0KRT16, KRT10, IVL
35ladd syndrome10.0FGF10, FGFR2
36craniosynostosis10.0FGFR2, FGF10
37middle ear cholesteatoma10.0IVL, PCNA
38adenoameloblastoma10.0PCNA, KRT1
39cervical cancer10.0KRT10, FGF10, IVL
40aorta atresia10.0FGF10, FGFR2
41mucoepidermoid carcinoma10.0IVL, PCNA
42epidermolysis bullosa simplex10.0IVL, KRT16, KRT1, KRT10
43lichen planus10.0IVL, KRT1, KRT16, KRT10
44leukoplakia10.0PCNA, IVL, KRT1
45cleft palate10.0FGF10, FGFR2
46infectious mononucleosis10.0FGFR2, FGF10, FGF7
47meningioma10.0FGFR2, PCNA, KRT1
48synostosis10.0FGFR2, FGF10
49bowen syndrome10.0IVL, PCNA, KRT1, KRT10, KRT16
50hepatocellular carcinoma10.0PCNA, KRT1, KRIT1, FGFR2

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Clinical Features for Acanthoma

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Drugs & Therapeutics for Acanthoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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32MalaCards
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MalaCards organs/tissues related to Acanthoma:

32
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8KRT1, KRT16, FGF10, FGFR2
2MP:00053828.7KRIT1, KRT10, KRT16, FGF10, FGFR2

Publications for Acanthoma

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50PubMed
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Articles related to Acanthoma:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Solitary epidermolytic acanthoma. (23710687)
2013
2
Clear cell acanthoma. (24087787)
2013
3
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? (24117902)
2013
4
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. (22568826)
2012
5
Dermoscopic features of reticulated acanthoma (superficial epithelioma) with sebaceous differentiation. (22858895)
2012
6
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
7
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
8
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? (21317609)
2011
9
Linear epidermolytic acanthoma of vulva: an unusual presentation. (20061731)
2010
10
Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation. (19889591)
2010
11
A case of polypoid clear cell acanthoma on the nipple. (20711275)
2010
12
Plaque form of warty dyskeratoma - acantholytic dyskeratotic acanthoma. (17518779)
2007
13
Reticulated acanthoma with sebaceous differentiation. (16625081)
2006
14
Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. (17083866)
2006
15
Clear cell acanthoma occurring on the hallux: the first case report. (16987281)
2006
16
Clear cell acanthoma successfully treated with a carbon dioxide laser. (16188196)
2005
17
Granular parakeratotic acanthoma. (16148407)
2005
18
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature. (16043921)
2005
19
A case of polypoid clear cell acanthoma on the scrotum. (15187345)
2004
20
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
21
The dermatoscopic pattern of clear-cell acanthoma resembles psoriasis vulgaris. (11549800)
2001
22
Polypoid clear cell acanthoma: case report. (11444278)
2000
23
Giant clear cell acanthoma. (11069543)
2000
24
Epidermolytic acanthomas: clinical characteristics and immunohistochemical features. (9185908)
1997
25
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
26
Cystic clear cell acanthoma. (7560357)
1995
27
Pigmented clear cell acanthoma. (8030764)
1994
28
Acantholytic acanthoma. (8517501)
1993
29
Melanocytes in clear cell acanthoma. (1928630)
1991
30
Acanthoma fissuratum. (2026947)
1991
31
Achromic verrucous large cell acanthoma. (2373780)
1990
32
Large cell acanthoma. A cytologic variant of Bowen's disease? (3232750)
1988
33
Pilar sheath acanthoma. (3579335)
1987
34
Giant clear cell acanthoma. (3655031)
1987
35
Clear cell acanthoma: a metabolic variant of seborrheic keratosis. (6966747)
1980
36
Disseminated epidermolytic acanthoma. (500873)
1979
37
Clear cell acanthoma. (422318)
1979
38
Acanthoma fissuratum. Histopathology and review of the literature. (477393)
1979
39
Acanthoma fissuratum--spectacle frame acanthoma. (55043)
1975
40
Clear cell acanthoma: a widely unknown tumor-like dermal lesion. (1212166)
1975
41
Some evidence concerning the sweat duct origin of clear cell acanthoma. (4129605)
1973
42
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. (5413257)
1970
43
Clear-cell acanthoma. Experience of 8 years. (4916780)
1970
44
Kerato-acanthoma. (5356657)
1969
45
Adeno-acanthoma of the ovary; report of 3 cases. (13740176)
1960
46
Molluscum sebaceum; kerato-acanthoma. (13510526)
1958
47
Kerato-acanthoma. (13189828)
1954
48
Uterine adeno-acanthoma with metastasis; report of a case. (13214679)
1954
49
Primary and secondary ovarian adeno-acanthoma. (13205409)
1954
50
Adeno-acanthoma of the cecum. (18862423)
1948

Genetic Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Acanthoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7FGFR2, FGF10
2
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9.1FGFR2, FGF7, FGF10
3
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9.1FGFR2, FGF10, FGF7
4
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9.1FGF7, FGF10, FGFR2
5
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9.1FGFR2, FGF10, FGF7
6
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9.1FGFR2, FGF10, FGF7
7
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9.1FGF7, FGF10, FGFR2
8
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9.1FGFR2, FGF10, FGF7
9
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9.1FGF7, FGF10, FGFR2
10
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9.1FGFR2, FGF10, FGF7
11
Development FGF-family signaling
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9.1FGF7, FGFR2, FGF10
12
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9.1FGFR2, FGF10, FGF7
13
Hide members
9.1FGF10, FGFR2, FGF7

Compounds for genes affiliated with Acanthoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glutamate4410.5KRIT1
2estrogen4410.4IVL
3tazarotene44 1111.2KRT10, KRT1
4isotretinoin44 1111.0KRT16, KRT1, KRT10
5dextran sulfate sodium449.8FGF7, FGF10
6palifermin44 1110.8FGF7, FGFR2
7dithranol449.8KRT16, IVL, KRT10
8calcipotriol44 59 28 1112.8KRT10, KRT16, IVL
9eosin449.7PCNA, KRT10
10dexamethasone44 49 28 1112.7PCNA, KRIT1
11sodium dodecylsulfate449.7IVL, KRT16, KRT1
12selenomethionine44 2410.6PCNA, KRIT1
13gf 109203x44 5910.6KRIT1, IVL, KRT10
14pimonidazole449.5IVL, PCNA
15retinoid449.5KRT16, IVL, KRT10, KRT1
16phenylalanine449.4KRIT1, KRT1, FGFR2
17ceramides449.4IVL, KRT1
18calcitriol44 59 11 2412.3IVL, KRT10, KRT16
19chondroitin sulfate44 2410.3IVL, FGF7, FGFR2
201,25 dihydroxy vitamin d3449.1IVL, FGF7, KRT10, KRT16
21proline449.1IVL, FGFR2, KRT16, KRT1, KRT10
2212-o-tetradecanoylphorbol 13-acetate449.0FGF7, FGFR2, IVL, KRT1
23vitamin d449.0IVL, FGF7, FGFR2, KRT10
24hematoxylin449.0KRT10, PCNA, IVL, KRT1
25steroid449.0FGF7, FGFR2, KRT16, KRT1, KRT10
26heparan sulfate44 2410.0IVL, FGF7, FGF10, FGFR2
27nicotine44 49 28 1112.0IVL, KRT1, PCNA
28thapsigargin44 599.9IVL, PCNA, KRIT1
29cyclophosphamide44 49 1110.8FGFR2, FGF7, PCNA
30adenylate448.7KRIT1, IVL, FGFR2, FGF7
31arginine448.7KRIT1, PCNA, FGFR2, KRT1, KRT10
32tamoxifen44 49 28 1111.7PCNA, FGFR2, FGF7, KRIT1
33aspartate448.6KRIT1, FGF7, KRT1, PCNA
34genistein44 28 59 2 11 2413.6PCNA, FGFR2, FGF7, KRIT1
355fluorouracil448.5FGF7, FGFR2, PCNA, IVL
36cyclosporin a44 28 5910.5IVL, FGF7, PCNA, KRIT1
37heparin44 28 11 2411.4FGF7, FGFR2, FGF10, PCNA
38progesterone44 59 28 11 2412.4FGFR2, PCNA, FGF7, KRT10, KRT1
39glutamine448.4PCNA, KRIT1, IVL, FGF7
40thymidine44 249.3IVL, FGF7, FGFR2, PCNA
41paraffin448.3PCNA, IVL, FGFR2, KRT16, KRT1, KRT10
42suramin44 28 1110.2KRIT1, IVL, PCNA, FGF7, FGFR2
43h2o2448.2PCNA, FGFR2, FGF7, KRIT1
44vegf448.1FGF7, FGF10, FGFR2, PCNA, IVL
45serine448.1KRT1, FGF7, KRIT1, KRT16, KRT10, IVL
46testosterone44 59 11 2411.1FGFR2, PCNA, KRIT1, KRT1, FGF7, FGF10
47cysteine448.0IVL, PCNA, FGFR2, FGF7, KRIT1
48tyrosine447.6FGFR2, FGF10, HPD, KRT1, IVL, KRT10
49bromodeoxyuridine447.6FGF7, KRT1, FGF10, KRT10, IVL, FGFR2
50retinoic acid44 248.3IVL, PCNA, FGFR2, FGF10, FGF7, KRT16

GO Terms for genes affiliated with Acanthoma

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16Gene Ontology
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Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1mesenchymal cell differentiation involved in lung developmentGO:06091510.1FGFR2, FGF10
2branch elongation involved in salivary gland morphogenesisGO:06066710.1FGFR2, FGF10
3mammary gland bud formationGO:06061510.0FGFR2, FGF10
4fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.0FGFR2, FGF10
5lacrimal gland developmentGO:03280810.0FGFR2, FGF10
6epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.0FGF10, FGFR2
7otic vesicle formationGO:03091610.0FGFR2, FGF10
8limb bud formationGO:06017410.0FGF10, FGFR2
9regulation of smoothened signaling pathwayGO:0085899.9FGF10, FGFR2
10embryonic digestive tract morphogenesisGO:0485579.9FGF10, FGFR2
11secretion by lung epithelial cell involved in lung growthGO:0610339.9FGF10, FGF7
12embryonic pattern specificationGO:0098809.8FGF10, FGFR2
13regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8FGF10, FGF7
14positive regulation of keratinocyte migrationGO:0515499.8FGF10, FGF7
15positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.8FGFR2, FGF7
16positive regulation of keratinocyte proliferationGO:0108389.8FGF10, FGF7
17branching involved in salivary gland morphogenesisGO:0604459.7FGF7, FGFR2
18protein localization to cell surfaceGO:0343949.7FGF7, FGF10
19positive chemotaxisGO:0509189.5FGF7, FGF10
20actin cytoskeleton reorganizationGO:0315329.5FGF7, FGF10
21hair follicle morphogenesisGO:0310699.4FGFR2, FGF10, FGF7
22positive regulation of epithelial cell proliferationGO:0506799.4FGFR2, FGF10, FGF7
23insulin receptor signaling pathwayGO:0082869.3FGFR2, FGF10, FGF7
24fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR2, FGF10, FGF7
25Fc-epsilon receptor signaling pathwayGO:0380959.1FGF7, FGF10, FGFR2
26angiogenesisGO:0015259.0KRIT1, FGF10, FGFR2
27epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR2, FGF10, FGF7
28phosphatidylinositol-mediated signalingGO:0480158.6FGF7, FGF10, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor bindingGO:0051049.5FGF7, FGF10
2chemoattractant activityGO:0420569.2FGF7, FGF10
3heparin bindingGO:0082019.0FGF7, FGF10, FGFR2

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet