MCID: ACN010
MIFTS: 46

Acanthoma malady

Rare diseases, Cancer diseases categories

Summaries for Acanthoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and FGFR ligand binding and activation. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are craniofacial and integument.

Wikipedia:66 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

acanthoma 9 44 11 63


External Ids:

Disease Ontology9 DOID:174
NCIt41 C7419
MeSH36 D049309

Related Diseases for Acanthoma

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18GeneCards, 19GeneDecks
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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma31.5IVL
2epidermolytic acanthoma31.2KRT1
3keratosis30.5KRT16, KRT1, KRT10, IVL, CLEC2A
4psoriasis30.3FGF7, KRIT1, IVL, KRT1, KRT10, KRT16
5keratoacanthoma29.9KRT10, PCNA, IVL
6papilloma29.9KRT10, PCNA, IVL
7large cell acanthoma10.6
8acantholytic acanthoma10.4
9pilar sheath acanthoma10.4
10seborrheic keratosis10.2
11epidermal nevus10.2
12epidermodysplasia verruciformis10.1
13muir-torre syndrome10.1
14cellulitis10.1
15onychocytic matricoma10.1
16monilethrix10.1KRT16
17hailey-hailey disease10.1IVL
18syringocystadenoma papilliferum10.1CLEC2A
19steatocystoma multiplex10.1KRT10, KRT16
20ichthyosis, cyclic, with epidermolytic hyperkeratosis10.1KRT10, KRT1
21epidermolytic hyperkeratosis10.1KRT10, KRT1
22palmoplantar keratoderma, epidermolytic10.1KRT1, KRT16
23keratoderma10.1KRT1, KRT16
24fibroma10.1IVL, KRT1
25congenital ichthyosiform erythroderma10.1IVL, KRT10
26actinic keratosis10.1PCNA
27cervical squamous cell carcinoma10.1IVL, KRT10
28cervical intraepithelial neoplasia10.1IVL, KRT10
29palmoplantar keratosis10.0KRT16, KRT1, KRT10
30nonepidermolytic palmoplantar keratoderma10.0KRT1, KRT10, KRT16
31basal cell carcinoma10.0KRT16, KRT10, IVL
32infectious mononucleosis10.0FGFR2, FGF7
33acrocephalosyndactylia10.0FGF7, FGFR2
34dermatitis10.0IVL, KRT16
35oral leukoplakia10.0KRT1, PCNA
36adenoameloblastoma10.0PCNA, KRT1
37middle ear cholesteatoma10.0PCNA, IVL
38smooth muscle tumor10.0PCNA, IVL
39mucoepidermoid carcinoma10.0IVL, PCNA
40epidermolysis bullosa simplex10.0KRT10, KRT16, KRT1, IVL
41lichen planus10.0KRT10, KRT16, IVL, KRT1
42leukoplakia10.0KRT1, PCNA, IVL
43molluscum contagiosum10.0
44inflamed seborrheic keratosis10.0
45adenoiditis10.0
46porokeratosis10.0
47endometriosis10.0
48inverted follicular keratosis10.0
49trichofolliculoma10.0
50warty dyskeratoma10.0

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Symptoms for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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34MalaCards
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MalaCards organs/tissues related to Acanthoma:

34
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acanthoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8KRT10, KRT16, KRIT1, FGFR2
2MP:00107718.4FGF7, FGFR2, KRT16, KRT1, KRT10
3MP:00053877.9FGF7, FGFR2, KRT1, KRT10, PCNA
4MP:00107687.4PCNA, KRT10, KRT1, KRT16, KRIT1, FGFR2

Publications for Acanthoma

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53PubMed
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Articles related to Acanthoma:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. (23539008)
2013
2
A shiny red papule in an older person. Clear cell acanthoma. (23944729)
2013
3
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
4
Isolated epidermolytic acanthoma in a renal transplant recipient. (21909223)
2011
5
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. (21965855)
2011
6
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? (21252636)
2011
7
Solitary epidermolytic acanthoma: a clinical and histopathological study. (20553361)
2011
8
Reticulated acanthoma with apocrine differentiation. (21265871)
2011
9
Postauricular pilar sheath acanthoma. (21769237)
2011
10
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. (20931670)
2010
11
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
12
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
13
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. (17214854)
2007
14
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. (17667172)
2007
15
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. (16984257)
2006
16
Clear cell acanthoma successfully treated with a carbon dioxide laser. (16188196)
2005
17
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. (14721785)
2003
18
Polypoid clear cell acanthoma of unusual size. (11174404)
2001
19
Polypoid clear cell acanthoma: case report. (11444278)
2000
20
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
21
Disseminated epidermolytic acanthoma probably related to trauma. (10583127)
1999
22
Epidermolytic acanthomas: clinical characteristics and immunohistochemical features. (9185908)
1997
23
Clear cell acanthoma developing in epidermal nevus. (9350108)
1997
24
Immunohistochemical characterization of keratin expression in clear cell acanthoma. (7547383)
1995
25
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
26
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. (8030765)
1994
27
Etretinate therapy of solar-related kerato acanthoma. (8240190)
1993
28
Melanocytes in clear cell acanthoma. (1928630)
1991
29
Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma]. (2172054)
1990
30
Achromic verrucous large cell acanthoma. (2373780)
1990
31
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
32
Large cell acanthoma. A cytologic variant of Bowen's disease? (3232750)
1988
33
Acantholytic acanthoma. (2461398)
1988
34
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. (3743846)
1986
35
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
36
Multiple kerato-acanthoma: a case report. (6162321)
1980
37
Disseminated epidermolytic acanthoma. (500873)
1979
38
Pilar sheath acanthoma. (718186)
1978
39
Squamous acanthoma of the oral mucosa. (4530964)
1974
40
Some evidence concerning the sweat duct origin of clear cell acanthoma. (4129605)
1973
41
Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration. (5413257)
1970
42
The ultrastructure of the pale cell acanthoma. (5774898)
1969
43
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
44
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
45
Adeno-acanthoma of the uterus. (14407697)
1959
46
Kerato-acanthoma; a lesion simulating carcinoma of skin. (13374633)
1956
47
Kerato-acanthoma. (13189828)
1954
48
Uterine adeno-acanthoma with metastasis; report of a case. (13214679)
1954
49
Multiple acanthoma (tumor-like keratosis of Poth). (13091403)
1953
50
Molluscum sebaceum kerato-acanthoma, benign epithelioma. (12997614)
1952

Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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51PathCards, 61Thomson Reuters, 56Reactome, 31KEGG
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Compounds for genes affiliated with Acanthoma

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1tazarotene46 1211.0KRT1, KRT10
2isotretinoin46 1210.9KRT10, KRT1, KRT16
3palifermin46 1210.7FGF7, FGFR2
4dithranol469.7KRT16, KRT10, IVL
5calcipotriol46 62 30 1212.7KRT16, KRT10, IVL
6eosin469.7KRT10, PCNA
7sodium dodecylsulfate469.6IVL, KRT1, KRT16
8gf 109203x46 6210.5KRIT1, KRT10, IVL
9selenomethionine46 2510.5KRIT1, PCNA
10pimonidazole469.4IVL, PCNA
11retinoid469.3KRT16, KRT1, KRT10, IVL
12calcitriol46 62 25 1212.3IVL, KRT10, KRT16
13chondroitin sulfate46 2510.2FGF7, FGFR2, IVL
141,25 dihydroxy vitamin d3469.1IVL, KRT10, KRT16, FGF7
15heparan sulfate46 2510.1IVL, FGFR2, FGF7
16vitamin d468.9IVL, KRT10, FGFR2, FGF7
17phenylalanine468.9KRT1, KRIT1, FGFR2
18nicotine46 30 52 1211.9KRT1, PCNA, IVL
1912-o-tetradecanoylphorbol 13-acetate468.9IVL, KRT1, FGFR2, FGF7
20proline468.9IVL, KRT10, KRT1, KRT16, FGFR2
21hematoxylin468.9IVL, PCNA, KRT10, KRT1
22thapsigargin46 629.8IVL, PCNA, KRIT1
23cyclophosphamide46 52 1210.8PCNA, FGFR2, FGF7
24adenylate468.7IVL, KRIT1, FGFR2, FGF7
25nitric oxide46 25 1210.6FGF7, FGFR2, KRIT1, KRT16
26tamoxifen46 52 30 1211.6PCNA, KRIT1, FGFR2, FGF7
27aspartate468.5PCNA, KRT1, KRIT1, FGF7
28genistein46 30 62 3 25 1213.5PCNA, KRIT1, FGFR2, FGF7
29arginine468.5PCNA, KRT10, KRT1, KRIT1, FGFR2
30glutamate468.5PCNA, KRT10, KRT1, KRIT1, FGFR2
315fluorouracil468.5IVL, PCNA, FGFR2, FGF7
32cyclosporin a46 30 6210.5IVL, PCNA, KRIT1, FGF7
33glutamine468.4IVL, PCNA, KRIT1, FGF7
34h2o2468.4PCNA, KRIT1, FGFR2, FGF7
35thymidine46 259.4FGF7, FGFR2, PCNA, IVL
36progesterone46 30 62 25 1212.3FGF7, FGFR2, KRT1, KRT10, PCNA
37steroid468.3IVL, KRT10, KRT1, KRT16, FGFR2, FGF7
38testosterone46 62 25 1211.2PCNA, KRT1, KRIT1, FGFR2, FGF7
39dexamethasone46 52 30 1211.2IVL, PCNA, KRT10, KRIT1, FGF7
40tyrosine468.1IVL, KRT10, KRT1, KRIT1, FGFR2, FGF7
41oligonucleotide468.1FGF7, FGFR2, PCNA, IVL
42suramin46 30 1210.1IVL, PCNA, KRIT1, FGFR2, FGF7
43paraffin468.1IVL, PCNA, KRT10, KRT1, KRT16, FGFR2
44calcium46 52 25 1211.1IVL, KRT10, KRT1, KRIT1, FGFR2, FGF7
45cysteine468.0IVL, PCNA, KRIT1, FGFR2, FGF7
46vegf468.0FGF7, FGFR2, PCNA, IVL
47serine467.9IVL, KRT10, KRT1, KRT16, KRIT1, FGFR2
48bromodeoxyuridine467.8FGF7, FGFR2, KRT1, KRT10, PCNA, IVL
49retinoic acid46 258.5IVL, PCNA, KRT10, KRT1, KRT16, FGFR2
50estrogen467.4IVL, PCNA, KRT10, KRT1, KRIT1, FGFR2

GO Terms for genes affiliated with Acanthoma

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17Gene Ontology
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Cellular components related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1KRT16, KRT1, KRT10, PCNA, IVL

Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:0302169.6KRT10, IVL
2positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.6FGF7, FGFR2
3branching involved in salivary gland morphogenesisGO:0604459.5FGFR2, FGF7
4hair follicle morphogenesisGO:0310699.5FGF7, FGFR2
5epidermis developmentGO:0085449.5FGF7, KRT16
6positive regulation of cell divisionGO:0517819.5FGFR2, FGF7
7positive regulation of epithelial cell proliferationGO:0506799.3FGF7, FGFR2
8epithelial cell differentiationGO:0308558.9FGFR2, PCNA
9phosphatidylinositol-mediated signalingGO:0480158.8FGF7, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9FGF7, FGFR2, KRIT1, KRT16, KRT1, PCNA

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet