MCID: ACN010
MIFTS: 44

Acanthoma malady

Summaries for Acanthoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT1 (keratin 1), and among its related pathways are NF-KappaB Family Pathway and Glioma. The compounds glutamate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and uterus, and related mouse phenotypes are integument and craniofacial.

Wikipedia:63 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Aliases & Classifications for Acanthoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

acanthoma 8 42 10 60


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Disease Ontology8 DOID:174
MeSH34 D049309
NCIt39 C7419

Related Diseases for Acanthoma

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17GeneCards, 18GeneDecks
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Diseases related to Acanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell acanthoma31.3IVL
2epidermolytic acanthoma30.9KRT1
3keratosis30.4CLEC2A, KRT16, KRT1, KRT10, IVL
4psoriasis30.3KRT1, KRT10, KRIT1, KRT16, IVL, FGF7
5squamous cell carcinoma30.2IVL, PCNA, KRT10, FGFR2, KRT16, FGF7
6molluscum contagiosum29.8IVL
7keratoacanthoma29.8KRT10, PCNA, IVL
8papilloma29.8IVL, KRT10, PCNA
9large cell acanthoma10.5
10acantholytic acanthoma10.5
11pilar sheath acanthoma10.4
12seborrheic keratosis10.2
13cellulitis10.1
14muir-torre syndrome10.1
15epidermodysplasia verruciformis10.1
16onychocytic matricoma10.1
17syringoma10.0KRT1
18monilethrix10.0KRT16
19ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
20epidermolytic hyperkeratosis10.0KRT1, KRT10
21cervical intraepithelial neoplasia10.0KRT10, IVL
22acrocephalosyndactylia10.0FGFR2
23keratoderma10.0KRT16, KRT1
24palmoplantar keratoderma, epidermolytic10.0KRT16, KRT1
25steatocystoma multiplex10.0KRT16, KRT10
26congenital ichthyosiform erythroderma10.0KRT10, IVL
27sarcoma10.0FGF7
28palmoplantar keratosis10.0KRT16, KRT10, KRT1
29nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1, KRT16
30syringocystadenoma papilliferum10.0CLEC2A
31hidradenoma10.0CLEC2A
32oral leukoplakia10.0PCNA, KRT1
33alopecia10.0CLEC2A
34basal cell carcinoma10.0KRT16, KRT10, IVL
35ladd syndrome10.0FGF10, FGFR2
36craniosynostosis10.0FGFR2, FGF10
37middle ear cholesteatoma10.0IVL, PCNA
38adenoameloblastoma10.0PCNA, KRT1
39cervical cancer10.0KRT10, FGF10, IVL
40aorta atresia10.0FGF10, FGFR2
41mucoepidermoid carcinoma10.0IVL, PCNA
42epidermolysis bullosa simplex10.0IVL, KRT16, KRT1, KRT10
43lichen planus10.0IVL, KRT1, KRT16, KRT10
44leukoplakia10.0PCNA, IVL, KRT1
45cleft palate10.0FGF10, FGFR2
46infectious mononucleosis10.0FGFR2, FGF10, FGF7
47meningioma10.0FGFR2, PCNA, KRT1
48synostosis10.0FGFR2, FGF10
49bowen syndrome10.0IVL, PCNA, KRT1, KRT10, KRT16
50hepatocellular carcinoma10.0PCNA, KRT1, KRIT1, FGFR2

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to acanthoma

Clinical Features for Acanthoma

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Drugs & Therapeutics for Acanthoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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32MalaCards
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MalaCards organs/tissues related to Acanthoma:

32
Skin, Ovary, Uterus, Testes

Animal Models for Acanthoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8KRT1, KRT16, FGF10, FGFR2
2MP:00053828.7KRIT1, KRT10, KRT16, FGF10, FGFR2

Publications for Acanthoma

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50PubMed
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Articles related to Acanthoma:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. (23083445)
2013
2
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. (23786782)
2013
3
Clear cell acanthoma induced by a dermatofibroma. (23122021)
2012
4
Clear cell acanthoma. (23171155)
2012
5
Rare persistent kerato-acanthoma of left lower eyelid: a case report. (23029833)
2012
6
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. (21070339)
2011
7
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). (20500186)
2010
8
Acantholytic tumor of the nail: acantholytic dyskeratotic acanthoma. (19602069)
2009
9
Clear cell acanthoma: new observations on dermatoscopy. (18583817)
2008
10
A glistening brown nodule. Pigmented clear cell acanthoma. (17310007)
2007
11
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. (17214854)
2007
12
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. (17667172)
2007
13
Clear cell acanthoma occurring in a split-thickness skin graft. (16327592)
2005
14
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. (14721785)
2003
15
Cell proliferation patterns in canine infundibular keratinizing acanthoma and well differentiated squamous cell carcinoma of the skin. (12152794)
2002
16
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. (12226748)
2002
17
Polypoid clear cell acanthoma of the scalp. (11236226)
2001
18
Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. (10810992)
2000
19
Acantholytic acanthoma. (10721663)
2000
20
Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient. (8537558)
1995
21
Isolated dyskeratotic acanthoma. A variant of isolated epidermolytic acanthoma. (7695013)
1995
22
Bilateral spectacle frame acanthoma. (7889674)
1994
23
Large-cell acanthoma is a distinctive condition. (1566974)
1992
24
Acanthoma supratrochantericum. (1628508)
1992
25
Epidermolytic acanthoma does not contain human papillomavirus DNA. (1649846)
1991
26
Melanocytes in clear cell acanthoma. (2393066)
1990
27
Pilar sheath acanthoma--report of a case with review of the literature. (2697113)
1989
28
Giant clear cell acanthoma in an atypical location. (2768587)
1989
29
Cryosurgical treatment of clear cell acanthoma. (2753589)
1989
30
Acantholytic acanthoma. (2461398)
1988
31
Vulvar localisation of epidermolytic acanthoma. A light- and electron-microscopic study. (3743846)
1986
32
Residents' corner: cryosurgery of clear cell acanthoma. (3722579)
1986
33
Disseminated epidermolytic acanthoma revealed by PUVA. (3770261)
1986
34
Clear cell acanthoma developing in epidermal nevus. (6092445)
1984
35
Pale cell acanthoma of the scrotum. (7128203)
1982
36
Multiple clear cell acanthoma. (7458369)
1981
37
Multiple kerato-acanthoma: a case report. (6162321)
1980
38
Pilar sheath acanthoma. A new benign follicular tumor. (521535)
1979
39
Pilar sheath acanthoma. (718186)
1978
40
Clear-cell acanthoma of vermilion mucosa of lower lip. (4524891)
1974
41
Clear cell acanthoma: clinicopathologic analysis of 37 new cases. (4687348)
1973
42
Multiple clear-cell acanthoma and ichthyosis. (4334961)
1972
43
Clear cell acanthoma of ear. Report of a case. (5802370)
1969
44
Kerato-acanthoma or squamous carcinoma? (5775799)
1969
45
Clinical recognition of clear-cell acanthoma (Degos'). (5350407)
1969
46
Kerato acanthoma (multiple variant). Report of a case. (6037976)
1967
47
Adeno-acanthoma of the uterus. (14407697)
1959
48
Kerato-acanthoma: an illustration of its behaviour and surgical management. (13843927)
1959
49
Molluscum sebaceum (kerato-acanthoma). (14365221)
1955
50
Molluscum sebaceum kerato-acanthoma, benign epithelioma. (12997614)
1952

Genetic Variations for Acanthoma

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Expression for genes affiliated with Acanthoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for genes affiliated with Acanthoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Acanthoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7FGF10, FGFR2
2
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9.1FGF7, FGF10, FGFR2
3
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9.1FGFR2, FGF10, FGF7
4
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9.1FGF7, FGF10, FGFR2
5
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9.1FGF7, FGF10, FGFR2
6
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9.1FGF7, FGF10, FGFR2
7
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9.1FGFR2, FGF10, FGF7
8
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9.1FGF7, FGF10, FGFR2
9
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9.1FGFR2, FGF10, FGF7
10
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9.1FGFR2, FGF10, FGF7
11
Development FGF-family signaling
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9.1FGF7, FGF10, FGFR2
12
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9.1FGF7, FGF10, FGFR2
13
Hide members
9.1FGF7, FGF10, FGFR2

Compounds for genes affiliated with Acanthoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Acanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glutamate4410.5KRIT1
2estrogen4410.4IVL
3tazarotene44 1111.2KRT10, KRT1
4isotretinoin44 1111.0KRT16, KRT1, KRT10
5dextran sulfate sodium449.8FGF7, FGF10
6palifermin44 1110.8FGF7, FGFR2
7dithranol449.8KRT16, IVL, KRT10
8calcipotriol44 59 28 1112.8KRT10, KRT16, IVL
9eosin449.7PCNA, KRT10
10dexamethasone44 49 28 1112.7PCNA, KRIT1
11sodium dodecylsulfate449.7IVL, KRT16, KRT1
12selenomethionine44 2410.6PCNA, KRIT1
13gf 109203x44 5910.6KRIT1, IVL, KRT10
14pimonidazole449.5IVL, PCNA
15retinoid449.5KRT16, IVL, KRT10, KRT1
16phenylalanine449.4KRIT1, KRT1, FGFR2
17ceramides449.4IVL, KRT1
18calcitriol44 59 11 2412.3IVL, KRT10, KRT16
19chondroitin sulfate44 2410.3IVL, FGF7, FGFR2
201,25 dihydroxy vitamin d3449.1IVL, FGF7, KRT10, KRT16
21proline449.1IVL, FGFR2, KRT16, KRT1, KRT10
2212-o-tetradecanoylphorbol 13-acetate449.0FGF7, FGFR2, IVL, KRT1
23vitamin d449.0IVL, FGF7, FGFR2, KRT10
24hematoxylin449.0KRT10, PCNA, IVL, KRT1
25steroid449.0FGF7, FGFR2, KRT16, KRT1, KRT10
26heparan sulfate44 2410.0IVL, FGF7, FGF10, FGFR2
27nicotine44 49 28 1112.0IVL, KRT1, PCNA
28thapsigargin44 599.9IVL, PCNA, KRIT1
29cyclophosphamide44 49 1110.8FGFR2, FGF7, PCNA
30adenylate448.7KRIT1, IVL, FGFR2, FGF7
31arginine448.7KRIT1, PCNA, FGFR2, KRT1, KRT10
32tamoxifen44 49 28 1111.7PCNA, FGFR2, FGF7, KRIT1
33aspartate448.6KRIT1, FGF7, KRT1, PCNA
34genistein44 28 59 2 11 2413.6PCNA, FGFR2, FGF7, KRIT1
355fluorouracil448.5FGF7, FGFR2, PCNA, IVL
36cyclosporin a44 28 5910.5IVL, FGF7, PCNA, KRIT1
37heparin44 28 11 2411.4FGF7, FGFR2, FGF10, PCNA
38progesterone44 59 28 11 2412.4FGFR2, PCNA, FGF7, KRT10, KRT1
39glutamine448.4PCNA, KRIT1, IVL, FGF7
40thymidine44 249.3IVL, FGF7, FGFR2, PCNA
41paraffin448.3PCNA, IVL, FGFR2, KRT16, KRT1, KRT10
42suramin44 28 1110.2KRIT1, IVL, PCNA, FGF7, FGFR2
43h2o2448.2PCNA, FGFR2, FGF7, KRIT1
44vegf448.1FGF7, FGF10, FGFR2, PCNA, IVL
45serine448.1KRT1, FGF7, KRIT1, KRT16, KRT10, IVL
46testosterone44 59 11 2411.1FGFR2, PCNA, KRIT1, KRT1, FGF7, FGF10
47cysteine448.0IVL, PCNA, FGFR2, FGF7, KRIT1
48tyrosine447.6FGFR2, FGF10, HPD, KRT1, IVL, KRT10
49bromodeoxyuridine447.6FGF7, KRT1, FGF10, KRT10, IVL, FGFR2
50retinoic acid44 248.3IVL, PCNA, FGFR2, FGF10, FGF7, KRT16

GO Terms for genes affiliated with Acanthoma

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16Gene Ontology
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Biological processes related to Acanthoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1mesenchymal cell differentiation involved in lung developmentGO:06091510.1FGFR2, FGF10
2branch elongation involved in salivary gland morphogenesisGO:06066710.1FGFR2, FGF10
3mammary gland bud formationGO:06061510.0FGFR2, FGF10
4fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.0FGFR2, FGF10
5lacrimal gland developmentGO:03280810.0FGFR2, FGF10
6epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.0FGF10, FGFR2
7otic vesicle formationGO:03091610.0FGFR2, FGF10
8limb bud formationGO:06017410.0FGF10, FGFR2
9regulation of smoothened signaling pathwayGO:0085899.9FGF10, FGFR2
10embryonic digestive tract morphogenesisGO:0485579.9FGF10, FGFR2
11secretion by lung epithelial cell involved in lung growthGO:0610339.9FGF10, FGF7
12embryonic pattern specificationGO:0098809.8FGF10, FGFR2
13regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8FGF10, FGF7
14positive regulation of keratinocyte migrationGO:0515499.8FGF10, FGF7
15positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.8FGFR2, FGF7
16positive regulation of keratinocyte proliferationGO:0108389.8FGF10, FGF7
17branching involved in salivary gland morphogenesisGO:0604459.7FGF7, FGFR2
18protein localization to cell surfaceGO:0343949.7FGF7, FGF10
19positive chemotaxisGO:0509189.5FGF7, FGF10
20actin cytoskeleton reorganizationGO:0315329.5FGF7, FGF10
21hair follicle morphogenesisGO:0310699.4FGFR2, FGF10, FGF7
22positive regulation of epithelial cell proliferationGO:0506799.4FGFR2, FGF10, FGF7
23insulin receptor signaling pathwayGO:0082869.3FGFR2, FGF10, FGF7
24fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR2, FGF10, FGF7
25Fc-epsilon receptor signaling pathwayGO:0380959.1FGF7, FGF10, FGFR2
26angiogenesisGO:0015259.0KRIT1, FGF10, FGFR2
27epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR2, FGF10, FGF7
28phosphatidylinositol-mediated signalingGO:0480158.6FGF7, FGF10, FGFR2, PCNA

Molecular functions related to Acanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor bindingGO:0051049.5FGF7, FGF10
2chemoattractant activityGO:0420569.2FGF7, FGF10
3heparin bindingGO:0082019.0FGF7, FGF10, FGFR2

Products for genes affiliated with Acanthoma

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Sources for Acanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet