MCID: ACN010
MIFTS: 31

Acanthoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

Aliases & Descriptions for Acanthoma:

Name: Acanthoma 12 50 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 42 D049309
NCIt 47 C7419
UMLS 69 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 50 an acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  there are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  the exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms. last updated: 3/26/2012

MalaCards based summary : Acanthoma is related to squamous cell carcinoma and clear cell acanthoma. An important gene associated with Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes.

Wikipedia : 71 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 28.4 FGF10 FGFR2 HPD KRT1 KRT10 KRT14
2 clear cell acanthoma 12.3
3 epidermolytic acanthoma 12.2
4 large cell acanthoma 12.2
5 pilar sheath acanthoma 12.2
6 acantholytic acanthoma 11.9
7 onychocytic matricoma 10.9
8 bradyopsia 10.2 KRT1 KRT10
9 palmoplantar keratoderma, nonepidermolytic 10.2 KRT1 KRT10
10 episodic angioedema with eosinophilia 10.2 KRT1 KRT10
11 subglottis verrucous carcinoma 10.1 KRT1 KRT10
12 thymus mucoepidermoid carcinoma 10.1 KRT1 KRT10
13 ebola hemorrhagic fever 10.1 KRT10 KRT14
14 anal margin basal cell carcinoma 10.1 KRT10 KRT14
15 partial of retinal vein occlusion 10.1 FGF10 FGFR2
16 dowling-degos disease 1 10.1 KRT10 KRT14
17 basaloid squamous cell carcinoma 10.1 KRT10 KRT14
18 female reproductive system disease 10.1 KRT10 KRT14
19 scaphocephaly, maxillary retrusion, and mental retardation 10.1 FGF10 FGFR2
20 secondary corneal edema 10.1 KRT10 KRT14
21 keratosis 10.1
22 cervical cancer, somatic 10.1 FGF10 FGFR2
23 leptospirosis 10.1 KRT10 KRT14
24 amebiasis 10.1 FGF10 KRT14
25 distal arthrogryposis 10.1 KRT10 KRT14
26 dermatitis, atopic 2 10.0 KRT1 KRT14
27 mongolian spot 10.0 KRT10 KRT14
28 chronic mountain sickness 10.0 KRT1 KRT9
29 white sponge nevus 1 10.0 KRT1 KRT9
30 cole-carpenter syndrome 1 10.0 KRT1 KRT10
31 pachyonychia congenita 2 10.0 KRT10 KRT9
32 psoriasis 9.9
33 vascular dementia 9.9 FGFR2 KRT10 KRT14
34 mixed cell adenoma 9.9 KRT1 KRT10 KRT14
35 colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas 9.9 KRT1 KRT10 KRT14
36 intraocular retinoblastoma 9.9 KRT1 KRT10 KRT14
37 skin papilloma 9.9 KRT1 KRT14
38 bone chondrosarcoma 9.9 KRT1 KRT14
39 autonomic nervous system neoplasm 9.9 KRT1 KRT10 KRT14
40 saddan 9.9 FGF10 FGFR2
41 erdheim-chester disease 9.9 KRT1 KRT10 KRT9
42 ciliary dyskinesia, primary, 1, with or without situs inversus 9.9 KRT1 KRT10 KRT9
43 keratosis palmoplantaris striata iii 9.8 KRT1 KRT10 KRT9
44 carotid artery thrombosis 9.8 KRT1 KRT10 KRT9
45 ichthyosis histrix, curth-macklin type 9.8 KRT1 KRT10 KRT9
46 bowen's disease 9.8
47 cellulitis 9.8
48 muir-torre syndrome 9.8
49 epidermodysplasia verruciformis 9.8
50 adenoiditis 9.6

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

39
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 214)
id Title Authors Year
1
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
2
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
3
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. ( 28007675 )
2016
4
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
5
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
6
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
7
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
8
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
9
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
10
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
11
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
12
Porokeratotic acanthoma. ( 25631132 )
2015
13
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
14
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
15
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
16
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2014
17
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
18
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
19
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
20
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
21
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
22
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
23
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
24
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
25
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
26
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
27
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014
28
An unusual location of a pilar sheath acanthoma. ( 25368479 )
2014
29
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
30
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
31
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
32
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ( 23786782 )
2013
33
Acanthoma fissuratum on the penis. ( 21913907 )
2013
34
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? ( 23651324 )
2013
35
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
36
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
37
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
38
Solitary epidermolytic acanthoma. ( 23710687 )
2013
39
Clear cell acanthoma. ( 24087787 )
2013
40
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. ( 23083445 )
2013
41
Clear cell acanthoma. ( 23171155 )
2012
42
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. ( 22568826 )
2012
43
Dermoscopic features of reticulated acanthoma (superficial epithelioma) with sebaceous differentiation. ( 22858895 )
2012
44
Rare persistent kerato-acanthoma of left lower eyelid: a case report. ( 23029833 )
2012
45
Clear cell acanthoma induced by a dermatofibroma. ( 23122021 )
2012
46
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? ( 21317609 )
2011
47
Solitary epidermolytic acanthoma: a clinical and histopathological study. ( 20553361 )
2011
48
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. ( 21965855 )
2011
49
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. ( 21070339 )
2011
50
Isolated epidermolytic acanthoma in a renal transplant recipient. ( 21909223 )
2011

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 FGF10 FGFR2 KRT1 KRT10 KRT14 KRT9
2
Show member pathways
11.38 KRT1 KRT10 KRT14 KRT9

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.16 KRT1 KRT10
2 extracellular matrix GO:0031012 9.13 FGF10 FGFR2 KRT1
3 intermediate filament GO:0005882 8.92 KRT1 KRT10 KRT14 KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.71 FGF10 KRT14 KRT9
2 keratinization GO:0031424 9.67 KRT1 KRT10 KRT14 KRT9
3 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.64 FGF10 FGFR2
4 inner ear morphogenesis GO:0042472 9.64 FGF10 FGFR2
5 positive regulation of epithelial cell proliferation GO:0050679 9.63 FGF10 FGFR2
6 peptide cross-linking GO:0018149 9.63 KRT1 KRT10
7 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.62 FGF10 FGFR2
8 positive regulation of Wnt signaling pathway GO:0030177 9.62 FGF10 FGFR2
9 lung alveolus development GO:0048286 9.61 FGF10 FGFR2
10 digestive tract development GO:0048565 9.61 FGF10 FGFR2
11 embryonic pattern specification GO:0009880 9.6 FGF10 FGFR2
12 hair follicle morphogenesis GO:0031069 9.59 FGF10 FGFR2
13 regulation of smoothened signaling pathway GO:0008589 9.58 FGF10 FGFR2
14 embryonic digestive tract morphogenesis GO:0048557 9.58 FGF10 FGFR2
15 epithelial cell differentiation GO:0030855 9.58 FGF10 FGFR2 KRT14
16 organ growth GO:0035265 9.57 FGF10 FGFR2
17 branching involved in salivary gland morphogenesis GO:0060445 9.56 FGF10 FGFR2
18 limb bud formation GO:0060174 9.55 FGF10 FGFR2
19 skin epidermis development GO:0098773 9.52 KRT1 KRT10
20 lacrimal gland development GO:0032808 9.51 FGF10 FGFR2
21 epidermis morphogenesis GO:0048730 9.49 FGF10 FGFR2
22 bud elongation involved in lung branching GO:0060449 9.48 FGF10 FGFR2
23 otic vesicle formation GO:0030916 9.46 FGF10 FGFR2
24 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.43 FGF10 FGFR2
25 branch elongation involved in salivary gland morphogenesis GO:0060667 9.32 FGF10 FGFR2
26 mammary gland bud formation GO:0060615 9.26 FGF10 FGFR2
27 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.16 FGF10 FGFR2
28 mesenchymal cell differentiation involved in lung development GO:0060915 8.96 FGF10 FGFR2
29 cornification GO:0070268 8.92 KRT1 KRT10 KRT14 KRT9

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF10 FGFR2
2 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF10 FGFR2
3 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
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28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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43 MESH via Orphanet
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48 NDF-RT
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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