MCID: ACN002
MIFTS: 57

Acanthosis Nigricans malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acanthosis Nigricans

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Aliases & Descriptions for Acanthosis Nigricans:

Name: Acanthosis Nigricans 11 48 27 50 39 13 68
an - Acanthosis Nigricans 11
 
Keratosis Nigricans 11
an 48

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:3138
ICD1030 L83
SNOMED-CT62 402599005, 72129000
MeSH39 D000052
NCIt45 C26687

Summaries for Acanthosis Nigricans

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NIH Rare Diseases:48 Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. This condition usually appears slowly and doesn't cause any symptoms other than skin changes. Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. Less commonly, the lips, palms, soles of the feet, or other areas may be affected. The exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. Last updated: 8/18/2014

MalaCards based summary: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and beare-stevenson cutis gyrata syndrome, and has symptoms including hyperkeratosis, hypohidrosis and hypertrichosis. An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Insulin-mediated glucose transport and Aldosterone-regulated sodium reabsorption. Affiliated tissues include skin, ovary and lung, and related mouse phenotypes are Decreased substrate adherent cell growth and Decreased human cytomegalovirus (HCMV) strain AD169 replication.

Wikipedia:71 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Related Diseases for Acanthosis Nigricans

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Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome with acanthosis nigricans34.4FGFR2, FGFR3
2beare-stevenson cutis gyrata syndrome32.5FGFR2, FGFR3
3alstrom syndrome31.6ALMS1, INS, LEP
4lipodystrophy, familial partial, 231.1INS, LEP, LMNA
5obesity29.4ADIPOQ, ALMS1, INS, INSR, LEP, SHBG
6diabetes mellitus, insulin-resistant, with acanthosis nigricans12.4
7saddan12.2
8insulin-resistant acanthosis nigricans, type a12.2
9acanthosis nigricans with muscle cramps and acral enlargement12.2
10diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension12.1
11cutis gyratum acanthosis nigricans craniosynostosis12.0
12leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome12.0
13lelis syndrome11.9
14hair-an syndrome11.5
15retinitis pigmentosa, deafness, mental retardation, and hypogonadism11.0
16lipodystrophy, congenital generalized, type 111.0
17rabson-mendenhall syndrome11.0
18hirschsprung disease ganglioneuroblastoma10.5INS, INSR
19adenocarcinoma10.5
20hyperandrogenism10.5
21flnb-related disorders10.4FGFR2, FGFR3
22plasmalogens synthesis deficiency isolated10.4FGFR2, FGFR3
23trigonocephaly 110.4FGFR2, FGFR3
24mite infestation10.4FGFR2, FGFR3
25bladder cancer, somatic10.4FGFR2, FGFR3
26apert syndrome10.4FGFR2, FGFR3
27hypogonadotropic hypogonadism 2 with or without anosmia10.4FGFR2, FGFR3
28central nervous system leukemia10.4FGFR2, FGFR3
29crouzon syndrome10.4
30fetal methyl mercury syndrome10.4INS, INSR
31accommodative esotropia10.4FGFR2, FGFR3
32glucosidase acid-1,4-alpha deficiency10.4INS, INSR
33polycystic ovary syndrome10.3
34gastric adenocarcinoma10.3
35maturity-onset diabetes of the young, type 1010.3INS, SHBG
36thanatophoric dysplasia, type i10.2FGFR2, FGFR3
37achondroplasia10.2
38glaucomatocyclitic crisis10.2FGFR2, FGFR3
39hypertelorism, preauricular sinus, punctal pits, and deafness10.2INS, SHBG
40pure mitochondrial myopathy10.2ADIPOQ, LEP
41lung cancer10.2
42mycosis fungoides10.2
43antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
44hypochondroplasia10.1
45hepatitis10.1
46pemphigus10.1
47conjunctival vascular disease10.1INS, SHBG
48tenosynovial giant cell tumor10.1ADIPOQ, LEP
49potato nose10.1ADIPOQ, LEP
50hypothyroidism10.1

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Symptoms & Phenotypes for Acanthosis Nigricans

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Human phenotypes related to Acanthosis Nigricans:

 64 (show all 8)
id Description HPO Frequency HPO Source Accession
1 hyperkeratosis64 hallmark (90%) HP:0000962
2 hypohidrosis64 typical (50%) HP:0000966
3 hypertrichosis64 typical (50%) HP:0000998
4 obesity64 typical (50%) HP:0001513
5 generalized hyperpigmentation64 typical (50%) HP:0007440
6 type ii diabetes mellitus64 occasional (7.5%) HP:0005978
7 cognitive impairment64 occasional (7.5%) HP:0100543
8 acanthosis nigricans64 HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

GenomeRNAi Phenotypes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-310.0FGFR2, FGFR3, INSR
2GR00248-A9.6FGFR2, FGFR3, IGF1R, INSR

MGI Mouse Phenotypes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

41 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ADIPOQ, FGFR2, FGFR3, IGF1R, LEP
2MP:00053718.6FGFR2, FGFR3, IGF1R, LEP, LMNA
3MP:00053778.4ALMS1, FGFR2, FGFR3, IGF1R, LMNA
4MP:00053917.9ALMS1, FGFR2, FGFR3, INS, LEP, LMNA
5MP:00053887.9ADIPOQ, FGFR2, FGFR3, IGF1R, INSR, LEP
6MP:00053697.8ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
7MP:00053907.8ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
8MP:00107717.7ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
9MP:00036317.7FGFR2, FGFR3, IGF1R, INS, INSR, LEP
10MP:00053817.5FGFR2, FGFR3, IGF1R, INS, INSR, LEP
11MP:00053857.4ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
12MP:00053977.3ADIPOQ, FGFR2, FGFR3, IGF1R, INS, INSR
13MP:00107687.3ADIPOQ, FGFR2, FGFR3, IGF1R, INS, INSR
14MP:00053897.2ALMS1, FGFR2, FGFR3, IGF1R, INS, INSR
15MP:00053797.0ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
16MP:00053707.0ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
17MP:00053846.6ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
18MP:00053756.6ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
19MP:00053876.6ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
20MP:00053676.5ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
21MP:00053866.5ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
22MP:00053786.5ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
23MP:00053766.4ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS

Drugs & Therapeutics for Acanthosis Nigricans

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Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminapprovedPhase 4, Phase 3, Phase 21746657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2Hypoglycemic AgentsPhase 4, Phase 3, Phase 25733
3insulinPhase 3, Phase 24524
4Insulin, Globin ZincPhase 3, Phase 24523
5AutoantibodiesPhase 3126
6
Leuprolideapproved, investigationalPhase 229353714-56-03911, 657181
Synonyms:
(D-Leu(6),des-gly-NH2(10),pro-ethylamide(9))-gonadotropin-releasing hormone
5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
AC1L1GZK
AC1L9B44
AC1Q5OPO
AR-1G9354
C07612
CID3911
CID441410
D00989
D08113
Enantone
Enantone (TN)
I04-0109
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
L001094
 
L002030
Leuprolide
Leuprolide acetate
Leuprolide acetate (USAN)
Leuprorelin
Leuprorelin (INN)
Leuprorelin acetate (JAN)
Leuprorelina
Leuproreline
Leuprorelinum
Lupron (TN)
N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
NSC377526
NSC746847
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-NHC2H5
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-nhet
acetic acid
leuprolide
7
SpironolactoneapprovedPhase 22221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
8
EnclomipheneinvestigationalPhase 216215690-57-0
Synonyms:
 
Clomiphene trans-form
9ZuclomiphenePhase 2162
10Estrogen Receptor ModulatorsPhase 2630
11EstrogensPhase 22470
12Natriuretic AgentsPhase 21645
13Estrogen AntagonistsPhase 21315
14ClomiphenePhase 2162
15Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
16Diuretics, Potassium SparingPhase 21827
17diureticsPhase 21372
18Antineoplastic Agents, HormonalPhase 25407
19Fertility AgentsPhase 2493
20Hormone AntagonistsPhase 212778
21Mineralocorticoid Receptor AntagonistsPhase 2333
22Selective Estrogen Receptor ModulatorsPhase 2586
23HormonesPhase 213979
24MineralocorticoidsPhase 2352
25CitrateNutraceuticalPhase 21106
26
Citric Acidnutraceutical, vet_approvedPhase 2110677-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
27
Pyridoxineapproved, nutraceutical, vet_approved18665-23-61054
Synonyms:
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
12001-78-4
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3-Hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
3-Hydroxy-4,5-dimethylol-alpha-picoline
3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol
4-Deoxypyridoxine 5'-phosphate
47862_SUPELCO
5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
58-56-0
58-56-0 (HCL)
58-56-0 (hydrochloride)
65-23-6
65-23-6 (Parent)
8059-24-3
85078-23-5
AC-12024
AC-14512
AC-907/25014218
AC1L1AMH
AC1L1LMI
AC1L2XK2
AC1Q22HP
AC1Q2G66
AC1Q3F63
AI3-19016
AIDS-006784
AIDS006784
AR-1A6363
AR-1J1632
Adermin hydrochloride
Adermine
Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Alestrol
BB_NC-0050
BIDD:PXR0180
BPBio1_000646
BSPBio_000586
Becilan
Beesix
Benadon
Bonasanit
C00314
C8H11NO3
CAS-58-56-0
CBDivE_015627
CCRIS 1903
CHEBI:16709
CHEBI:30961
CHEMBL1200756
CHEMBL1364
CID104817
CID1054
CID6019
CPD0-1221
Campoviton 6
Cernevit-12
D02179
D025101
D08454
DB00165
EINECS 200-386-2
EINECS 200-603-0
EINECS 232-503-8
Godabion
Gravidox
HMS1569N08
HMS2093L07
HSDB 1212
Hexa-Betalin
Hexa-Betalin (R)
Hexa-betalin (TN)
Hexabetalin
Hexabione hydrochloride
 
Hexavibex
Hexermin
Hexermine
Hexobion
Hydoxin
I02-1897
I02-2297
KST-1A8556
LS-134393
LS-187072
LS-2332
MLS001074329
MLS002153915
MolPort-002-137-856
MolPort-002-319-991
MolPort-005-933-330
NCGC00016261-01
NCGC00164317-01
NCGC00180946-01
NSC 36225
NSC36225
NSC36225 (HCL)
Nestrex
Oprea1_061614
P0561
P4722_SIAL
P5669_SIGMA
P6280_SIGMA
P8666_SIGMA
P9755_SIAL
PN
PN HCl
PYRIDOXINE HYDROCHLORIDE
PYRIDOXINE HYDROCHLORIDE, U.S.P.
Paxadon
Piridossina
Piridossina [DCIT]
Piridoxina
Piridoxina [INN-Spanish]
Prestwick0_000623
Prestwick1_000623
Prestwick2_000623
Prestwick3_000623
Prestwick_925
Pydox
Pyridipca
Pyridox
Pyridoxin
Pyridoxin hydrochloride
Pyridoxine
Pyridoxine (INN)
Pyridoxine HCl
Pyridoxine Hydrochloride (B6)
Pyridoxine [INN:BAN]
Pyridoxine chloride
Pyridoxine hydrochloride (JP15/USP)
Pyridoxine hydrochloride [USAN:JAN]
Pyridoxine hydrogen chloride
Pyridoxine monohydrochloride
Pyridoxine, hydrochloride
Pyridoxine-HCl Microencapsulated
Pyridoxinium chloride
Pyridoxinum
Pyridoxinum [INN-Latin]
Pyridoxinum hydrochloricum
Pyridoxinum hydrochloricum (Hungarian)
Pyridoxol
Pyridoxol hydrochloride
Pyridoxol, hydrochloride
Pyridoxolum
Rodex
Rodex (R)
Rodex TD
SMP2_000230
SMR000674613
SPBio_002805
STK177324
STOCK1N-08684
Spondylonal
Tex Six T.R.
TimTec1_000657
UNII-68Y4CF58BV
UNII-KV2JZ1BI6Z
Vitamin B 6
Vitamin B6
Vitamin B6-hydrochloride
Vitamin V6
Vitamin V6 (TN)
Vitamin-?B6
Vitamin-?B6 hydrochloride
Vitaped
WLN: T6NJ B1 CQ D1Q E1Q &GH
ZINC00049154
ZINC21983293
bmse000288
c1302
component of Alestrol
nchembio.93-comp1
pyridoxine
vitamin B6
28
Pyridoxalapproved, nutraceutical18566-72-81050
Synonyms:
2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde
 
3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
Piridoxal
Pyridoxal
Pyridoxaldehyde
29
Melatoninapproved, nutraceutical, vet_approved25573-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
30Vitamin B 6186
31Vitamins5095
32Vitamin B Complex4229
33Protective Agents7190
34Antioxidants2928
35Calcium, Dietary5525
36Central Nervous System Depressants12806

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With ObesityNot yet recruitingNCT02438020Phase 4
2Adjunctive Metformin Therapy in Double DiabetesCompletedNCT01334125Phase 3
3Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans SyndromeCompletedNCT00004311Phase 2
4Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome PatientsCompletedNCT02562664Phase 2
5Prevalence of Carbohydrate Intolerance in Lean and Obese ChildrenUnknown statusNCT00000112
6Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With HyperinsulinemiaCompletedNCT01125150
7Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid MetabolismCompletedNCT02604095

Search NIH Clinical Center for Acanthosis Nigricans


Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

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Genetic tests related to Acanthosis Nigricans:

id Genetic test Affiliating Genes
1 Acanthosis Nigricans27

Anatomical Context for Acanthosis Nigricans

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MalaCards organs/tissues related to Acanthosis Nigricans:

36
Skin, Ovary, Lung, Prostate, Liver, Thyroid, B cells

Publications for Acanthosis Nigricans

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Articles related to Acanthosis Nigricans:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges. (28031729)
2017
2
The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors. (28081576)
2017
3
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. (27746646)
2016
4
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. (27167874)
2016
5
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer. (27536145)
2016
6
Acanthosis Nigricans associated with clear-cell renal cell carcinoma. (27284539)
2016
7
Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans. (26860419)
2016
8
Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection. (27598021)
2016
9
FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. (27190511)
2016
10
Linear acanthosis nigricans on the anterior neck: Koebner phenomenon observed in a patient with acanthosis nigricans. (27569660)
2016
11
Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: a case report. (27987313)
2016
12
Bilaterally mammary acanthosis nigricans as paraneoplastic manifestation of prostate adenocarcinoma. (27595210)
2016
13
Unilateral nevoid acanthosis nigricans treated with CO2 laser. (27457822)
2016
14
A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism. (27505086)
2016
15
Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity. (26588491)
2016
16
Acanthosis Nigricans as a Clinical Predictor of Insulin Resistance in Obese Children. (28090470)
2016
17
Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR3 mutation. (26818779)
2016
18
Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial. (27999648)
2016
19
ACANTHOSIS NIGRICANS AND SEVERE INSULIN RESISTANCE IN A BOY WITH ATAXIA. (27124696)
2016
20
A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR. (27990384)
2016
21
Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific. (27631218)
2016
22
Lelis Syndrome: A Rare Cause of Acanthosis Nigricans. (27595879)
2016
23
Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease. (27051830)
2016
24
IMAGES IN CLINICAL MEDICINE. Acanthosis Nigricans and Insulin Resistance. (27305209)
2016
25
Acanthosis nigricans in insulinoma: before and after successful surgical enucleation. (27836838)
2016
26
Unusual Presentation of Acanthosis Nigricans Associated With Metabolic Syndrome. (26861532)
2015
27
Differentiating confluent and reticulated papillomatosis from acanthosis nigricans. (26264983)
2015
28
Paraneoplastic acanthosis nigricans: the first reported case associated with a SAczary syndrome. (26264676)
2015
29
Florid cutaneous manifestations with acanthosis nigricans in a lung cancer patient. (25734371)
2015
30
Regression of Acanthosis Nigricans with the Addition of Sitagliptin and Pioglitazone. (26360673)
2015
31
Evaluation of depressive symptoms in obese patients with or without acanthosis nigricans. (26188226)
2015
32
Acral Acanthosis Nigricans in a Case of Scleroderma. (26288450)
2015
33
Acanthosis nigricans: A fold (intertriginous) dermatosis. (26051063)
2015
34
Costello syndrome with severe nodulocystic acne: unexpected significant improvement of acanthosis nigricans after oral isotretinoin treatment. (25815234)
2015
35
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. (25657419)
2015
36
Oral Malignant Acanthosis Nigricans and Tripe Palms Associated With Renal Urothelial Carcinoma. (26309230)
2015
37
Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. (25817595)
2015
38
Association of the Family Nutrition and Physical Activity Screening Tool with Weight Status, Percent Body Fat, and Acanthosis Nigricans in Children from a Low Socioeconomic, Urban Community. (26675805)
2015
39
Social anxiety, depression and self-esteem in obese adolescent girls with acanthosis nigricans. (25800478)
2015
40
Familial hypochondroplasia and acanthosis nigricans with FGFR3 K650T mutation. (25809207)
2015
41
Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome. (26229697)
2015
42
A case of acanthosis nigricans coexisting with mycosis fungoides. (26436975)
2015
43
Unilateral nevoid acanthosis nigricans. (26123470)
2015
44
Perioral Acanthosis nigricans. (26388207)
2015
45
Acanthosis nigricans in type 2 diabetes: prevalence, correlates and potential as a simple clinical screening tool - a cross-sectional study in the Caribbean. (25031628)
2014
46
Malignant acanthosis nigricans, florid cutaneous papillomatosis and tripe palms syndrome associated with gastric adenocarcinoma. (24683401)
2014
47
A case of hyperpigmentation and acanthosis nigricans by testosterone injections. (24505054)
2014
48
Correlates of Leisure-Time Physical Activity Participation Among Latino Children and Adolescents with Acanthosis Nigricans. (24500001)
2014
49
Epidermal insulin resistance as a therapeutic target in acanthosis nigricans? (24514457)
2014
50
Hypochondroplasia, Acanthosis Nigricans, and Insulin Resistance in a Child with FGFR3 Mutation: Is It Just an Association? (25505998)
2014

Variations for Acanthosis Nigricans

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Expression for genes affiliated with Acanthosis Nigricans

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Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

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Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.8INS, INSR
29.8INS, INSR
39.8INS, INSR
49.4INS, INSR, LEP
5
Show member pathways
9.4INS, INSR, LEP
6
Show member pathways
9.4ADIPOQ, INS, INSR
7
Show member pathways
9.3IGF1R, INS, INSR
8
Show member pathways
9.3IGF1R, INS, INSR
99.3IGF1R, INS, INSR
109.3IGF1R, INS, INSR
119.3FGFR2, FGFR3, IGF1R
129.3ADIPOQ, INS, LEP
139.0FGFR2, FGFR3, IGF1R, INSR
149.0FGFR2, FGFR3, IGF1R, INSR
15
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
16
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
17
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
189.0FGFR2, FGFR3, IGF1R, INSR
198.8ADIPOQ, IGF1R, INS, INSR
20
Show member pathways
8.8ADIPOQ, IGF1R, INS, INSR
218.6ADIPOQ, INS, LEP, LMNA
22
Show member pathways
8.6FGFR2, FGFR3, IGF1R, INS, INSR
238.6FGFR2, FGFR3, IGF1R, INS, INSR
24
Show member pathways
8.6FGFR2, FGFR3, IGF1R, INS, INSR
25
Show member pathways
8.6ADIPOQ, FGFR2, FGFR3, INS, LEP
26
Show member pathways
8.2FGFR2, FGFR3, IGF1R, INS, INSR, LEP

GO Terms for genes affiliated with Acanthosis Nigricans

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Cellular components related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1ADIPOQ, FGFR2, FGFR3, INS, LEP, SHBG

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1activation of protein kinase B activityGO:003214810.6INS, INSR
2bone mineralizationGO:003028210.5FGFR2, FGFR3
3bone morphogenesisGO:006034910.5FGFR2, FGFR3
4positive regulation of glycogen biosynthetic processGO:004572510.5INS, INSR
5positive regulation of glycolytic processGO:004582110.5INS, INSR
6positive regulation of mitotic nuclear divisionGO:004584010.5INS, INSR
7positive regulation of phospholipase activityGO:001051810.5FGFR2, FGFR3
8positive regulation of respiratory burstGO:006026710.5INS, INSR
9positive regulation of developmental growthGO:004863910.4INSR, LEP
10negative regulation of gluconeogenesisGO:004572110.4ADIPOQ, INS
11positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.4FGFR3, LEP
12positive regulation of insulin receptor signaling pathwayGO:004662810.4INS, LEP
13positive regulation of cellular protein metabolic processGO:003227010.4ADIPOQ, INS
14fatty acid beta-oxidationGO:000663510.4ADIPOQ, LEP
15peptidyl-tyrosine phosphorylationGO:001810810.2FGFR2, FGFR3, INSR
16positive regulation of protein kinase B signalingGO:005189710.0INS, INSR, LEP
17positive regulation of glucose importGO:004632610.0ADIPOQ, INS, INSR
18regulation of protein localization to nucleusGO:190018010.0LEP, LMNA
19insulin receptor signaling pathwayGO:000828610.0IGF1R, INS, INSR
20phosphatidylinositol-mediated signalingGO:004801510.0FGFR2, FGFR3, IGF1R
21positive regulation of cell migrationGO:003033510.0IGF1R, INS, INSR
22glucose metabolic processGO:000600610.0ADIPOQ, INS, LEP
23positive regulation of DNA replicationGO:004574010.0IGF1R, INS, INSR
24response to activityGO:00148239.8ADIPOQ, INSR, LEP
25regulation of fat cell differentiationGO:00455989.8ALMS1, LEP
26response to tumor necrosis factorGO:00346129.7ADIPOQ, INSR
27response to ethanolGO:00454719.7ADIPOQ, INSR, LEP
28protein autophosphorylationGO:00467779.5FGFR2, FGFR3, IGF1R, INSR
29positive regulation of MAPK cascadeGO:00434109.4FGFR2, FGFR3, INS, INSR, LEP
30positive regulation of cell proliferationGO:00082848.9FGFR2, FGFR3, IGF1R, INS, INSR, LEP
31glucose homeostasisGO:00425938.9ADIPOQ, ALMS1, INS, INSR, LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:001713410.4FGFR2, FGFR3
2fibroblast growth factor-activated receptor activityGO:000500710.4FGFR2, FGFR3
3insulin-like growth factor receptor bindingGO:000515910.4INS, INSR
4insulin bindingGO:004355910.2IGF1R, INSR
5insulin receptor substrate bindingGO:004356010.2IGF1R, INSR
6insulin-like growth factor I bindingGO:003199410.2IGF1R, INSR
7insulin receptor bindingGO:000515810.2IGF1R, INS
8phosphatidylinositol 3-kinase bindingGO:004354810.2IGF1R, INSR
9hormone activityGO:00051799.9ADIPOQ, INS, LEP
10protein tyrosine kinase activityGO:00047139.0FGFR2, FGFR3, IGF1R, INSR

Sources for Acanthosis Nigricans

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet