AN
MCID: ACN002
MIFTS: 70

Acanthosis Nigricans (AN) malady

Skin category

Summaries for Acanthosis Nigricans

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Acanthosis nigricans is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. these symptoms are more common in people with cancer. the exact cause of this condition is not well understood; but it can be genetically inherited or related to medical problems such as obesity, some prescription drugs, and cancer. last updated: 7/25/2011

MalaCards: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to insulin resistance and adenocarcinoma, and has symptoms including generalized obesity, intellectual deficit/mental/psychomotor retardation/learning disability and autosomal dominant inheritance. An important gene associated with Acanthosis Nigricans is INSR (insulin receptor), and among its related pathways are IRS activation and Selected targets of GCR-alpha. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Wikipedia:64 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Description from OMIM:47 200170,100600

Aliases & Classifications for Acanthosis Nigricans

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
acanthosis nigricans:
Inheritance: Autosomal dominant; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acanthosis nigricans 8 43 10 45 49 47 61
an - acanthosis nigricans 8
keratosis nigricans 8
an 43


External Ids:

Disease Ontology8 DOID:3138
NCIt40 C26687
MeSH35 D000052
MESH via Orphanet36 D000052
SNOMED-CT57 72129000, 402599005
ICD10 via Orphanet26 L83
SNOMED-CT via Orphanet58 402599005
UMLS via Orphanet62 C0000889
ICD1025 L83

Related Diseases for Acanthosis Nigricans

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 6596)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.6BSCL2, GH1, SHBG, AGPAT2, IGF1R, IGF1
2adenocarcinoma31.2IGF1R, CYP21A2, FGFR2, INSR, SLC2A4, TGFA
3crouzon syndrome31.1FGFR2, FGFR3
4hyperandrogenism31.1GH1, SHBG, IGF1R, IGF1, CYP21A2, INS
5adenoma31.1GH1, SHBG, IGF1R, IGF1, CYP21A2, INS
6arthritis31.1LEP, ADIPOQ
7polycystic ovary syndrome30.9INS, INSR, LEP, LMNA, SLC2A4, ADIPOQ
8achondroplasia30.9FGFR2, FGFR3
9colorectal cancer30.8IGF1R, IGF1, FGFR2, FGFR3, INSR
10alzheimer's disease30.7SHBG, FGFR3, INS, INSR, SLC2A3
11squamous cell carcinoma30.7IGF1R, MC1R, FGFR2, FGFR3, INSR, SLC2A3
12atherosclerosis30.7SHBG, IGF1, INS, LEP, LMNA, ADIPOQ
13cystic fibrosis30.6INS
14coronary artery disease,30.6INS, INSR, LMNA, ADIPOQ, ADRB3
15osteoporosis30.6GH1, SHBG, IGF1, CYP21A2, LEP
16astrocytoma30.6FGFR2, SLC2A3, TGFA
17hypochondroplasia30.5FGFR3, FGFR2
18amenorrhea30.5SHBG, IGF1, INS, LEP
19acromegaly30.5GH1, SHBG, IGF1, INS, LEP, ADIPOQ
20cushing's syndrome30.5GH1, IGF1, CYP21A2, LEP, ADIPOQ
21alopecia30.5SHBG
22blindness30.5INS
23hypoglycemia30.5GH1, IGF1, INS, INSR, SLC2A3, SLC2A4
24pheochromocytoma30.5INSR
25infertility30.4LEP, INS, CYP21A2, SHBG
26osteoarthritis30.4IGF1
27hypercholesterolemia30.4ADIPOQ, INSR, INS
28coronary heart disease30.4ADRB3, ADIPOQ, LMNA, LEP, INS, SHBG
29anorexia nervosa30.4GH1, SHBG, IGF1, LEP, ADIPOQ
30beare-stevenson cutis gyrata syndrome30.4FGFR2
31mental retardation30.4FGFR3, SHBG
32rabson-mendenhall syndrome30.4IGF1, INS, INSR
33graves' disease30.4SHBG, IGF1R, CYP21A2
34osteogenesis imperfecta30.4FGFR3
35gestational diabetes30.4INS, INSR, LEP, SLC2A3, SLC2A4, ADIPOQ
36celiac disease30.4CYP21A2
37acne30.3SHBG
38turner syndrome30.3GH1, SHBG, IGF1, CYP21A2
39metabolic acidosis30.3IGF1
40prader-willi syndrome30.3GH1, IGF1, INS, LEP, ADIPOQ
41precocious puberty30.3GH1, SHBG, IGF1, CYP21A2, LEP, TGFA
42thyrotoxicosis30.2INS
43congenital hypothyroidism30.2CYP21A2
44bronchitis30.2ADIPOQ, LEP, SHBG
45bulimia nervosa30.2LEP
46gynecomastia30.2SHBG
47growth hormone deficiency30.2GH1, IGF1, INS, LEP, ADIPOQ
48thyroid cancer30.2FGFR2
49prolactinoma30.2IGF1, GH1
50klinefelter's syndrome30.2CYP21A2, SHBG

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Clinical Features for Acanthosis Nigricans

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

200170,100600

Clinical synopsis from OMIM:

100600

Symptoms:

49 (show all 8)
  • generalized obesity
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • autosomal dominant inheritance
  • insulin-independent/type 2 diabetes
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • hirsutism/hypertrichosis/increased body hair
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • diffuse/generalised skin hyperpigmentation/melanoderma

Drugs & Therapeutics for Acanthosis Nigricans

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acanthosis Nigricans

Drug clinical trials:

Search ClinicalTrials for Acanthosis Nigricans

Search NIH Clinical Center for Acanthosis Nigricans

Search CenterWatch for Acanthosis Nigricans

Genetic Tests for Acanthosis Nigricans

Anatomical Context for Acanthosis Nigricans

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acanthosis Nigricans:

33
Skin, Ovary, Liver, Kidney, Lymph node, Lung, Bone marrow, Heart, Skeletal muscle, Thyroid, Adrenal gland, Breast, Prostate, Cervix, Myeloid, B lymphoblasts, B cells

Animal Models for Acanthosis Nigricans or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acanthosis Nigricans:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.4FGFR2, SLC2A4
2MP:000537110.3AGPAT2, LMNA
3MP:00053889.7IGF1R, IGF1, FGFR2, FGFR3, INSR
4MP:00053779.6MC1R, FGFR3, LMNA
5MP:00020069.4IGF1R, IGF1, MC1R, FGFR2, FGFR3
6MP:00053909.4IGF1R, IGF1, FGFR2, FGFR3, LMNA, TGFA
7MP:00053899.3GH1, FGFR2, FGFR3, INSR, SLC2A3, TGFA
8MP:00053759.1TGFA, BSCL2, GH1, IGF1R, LMNA, SLC2A4
9MP:00107719.0BSCL2, AGPAT2, IGF1R, MC1R, FGFR2, INS
10MP:00053829.0TGFA, LMNA, FGFR3, FGFR2, MC1R, IGF1R
11MP:00053698.9IGF1R, IGF1, INS, INSR, LEP, LMNA
12MP:00053678.9BSCL2, AGPAT2, IGF1, FGFR2, FGFR3, INS
13MP:00053978.6BSCL2, AGPAT2, IGF1R, IGF1, FGFR2, FGFR3
14MP:00053708.6BSCL2, GH1, AGPAT2, IGF1R, FGFR2, INS
15MP:00053818.5BSCL2, AGPAT2, IGF1R, FGFR2, FGFR3, INS
16MP:00053858.5BSCL2, IGF1R, IGF1, FGFR2, INS, INSR
17MP:00053848.4MC1R, IGF1, IGF1R, BSCL2, FGFR2, FGFR3
18MP:00036318.3GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
19MP:00053878.1FGFR2, IGF1, IGF1R, AGPAT2, BSCL2, FGFR3
20MP:00053868.1FGFR2, MC1R, IGF1R, AGPAT2, BSCL2, FGFR3
21MP:00107688.0FGFR2, IGF1, IGF1R, AGPAT2, BSCL2, FGFR3
22MP:00053767.6FGFR2, IGF1, IGF1R, AGPAT2, GH1, BSCL2
23MP:00053787.1FGFR2, MC1R, IGF1, IGF1R, AGPAT2, GH1

Publications for Acanthosis Nigricans

Sources:
51PubMed
See all sources

Articles related to Acanthosis Nigricans:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with acanthosis nigricans in obese adolescents. (22288782)
2012
2
Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma. (21738980)
2011
3
A study of pathogenesis of acanthosis nigricans and its clinical implications. (22345770)
2011
4
The involvement of insulin receptor genotypes in pre- and co-obese acanthosis Nigricans children and adolescent. (20857837)
2010
5
Body mass index percentile more sensitive than acanthosis nigricans for screening Native American children for diabetes risk. (21053710)
2010
6
Acanthosis nigricans identifies youth at high risk for metabolic abnormalities. (19796772)
2010
7
Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature. (19514649)
2009
8
Clearance of acanthosis nigricans associated with insulinoma following surgical resection. (18669553)
2008
9
Nevoid acanthosis nigricans with subtle melanocyte hyperplasia. (18489033)
2008
10
Oral acanthosis nigricans: case report and comparison with literature reports. (18541106)
2008
11
Severe acanthosis nigricans in a 17 year-old female with partial lipodystrophic syndrome. (19189695)
2008
12
Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate. (17939948)
2007
13
Acanthosis nigricans. (17874609)
2007
14
Adipose tissue and liver lipid metabolism in obese children: role of the body mass index and the presence of acanthosis nigricans. (17725635)
2007
15
Photo quiz. Case 7. Acanthosis nigricans. (18193511)
2007
16
Nevoid acanthosis nigricans localized to the umbilicus. (16700838)
2006
17
Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: a case report. (15663660)
2005
18
A case of nevoid acanthosis nigricans. (15202846)
2004
19
Generalized acanthosis nigricans in early childhood. (11438001)
2001
20
Diabetic ketoacidosis in association with acanthosis nigricans. (11421534)
2000
21
Malignant acanthosis nigricans in a 2 year old child with Wilm's Tumour. (20921706)
1998
22
Treatment of mixed-type acanthosis nigricans with topical calcipotriol. (9893209)
1998
23
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
24
Hyperinsulinemia and acanthosis nigricans in African Americans. (9264219)
1997
25
Is hyperinsulinemia the cause of acanthosis nigricans in the type B syndrome of insulin resistance? (9167127)
1997
26
Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans. (9007703)
1996
27
Prevalence and significance of Acanthosis nigricans in children and adolescents. (17372496)
1996
28
A case of severe hyperandrogenism, acanthosis nigricans and over diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management. (8915663)
1996
29
Topical tretinoin in acanthosis nigricans. (20948022)
1996
30
Childhood acanthosis nigricans. (7648884)
1995
31
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. (7650669)
1995
32
Keratin pattern of acanthosis nigricans in syndromelike association with polythelia, polycystic kidneys, and syndactyly. (7689823)
1993
33
Acanthosis nigricans and bile duct malignancy. (7904407)
1993
34
Insulin resistant diabetes, acanthosis nigricans and Bartter's syndrome, a fortuitous association?]. (1497426)
1992
35
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990
36
Concomitant Becker's naevus and acanthosis nigricans. (2757937)
1989
37
Improvement of oral lesions associated with malignant acanthosis nigricans after treatment of lung cancer. (2787900)
1989
38
Insulin resistance and acanthosis nigricans, type A: case report. (2473702)
1989
39
Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). (2460770)
1988
40
Acanthosis nigricans associated with mycosis fungoides. (3192779)
1988
41
Familial acanthosis nigricans. A longitudinal study. (3305929)
1987
42
Insulin resistant diabetes mellitus associated with acanthosis nigricans and systemic lupus erythematosus in a Nigerian male. (2994443)
1985
43
An unusual association of acanthosis nigricans and Crouzon's disease--a case report. (3894462)
1985
44
Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. (2933497)
1985
45
A case of acanthosis nigricans--an investigative approach. (6692587)
1984
46
Acanthosis nigricans and insulin resistance. (6373859)
1984
47
Treatment of malignant acanthosis nigricans with cyproheptadine. (7082574)
1982
48
Generalized acanthosis nigricans. (7274513)
1981
49
Acanthosis nigricans, florid cutaneous papillomatosis and the sign of Leser-TrA"lat. (7297118)
1981
50
Cutaneous manifestation of internal malignancies (I). Acanthosis nigricans. (659033)
1978

Genetic Variations for Acanthosis Nigricans

Expression for genes affiliated with Acanthosis Nigricans

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acanthosis Nigricans

Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 53R&D Systems, 4Cell Signaling Technology, 60Tocris Bioscience, 50PharmGKB
See all sources

Pathways related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2INSR, INS
210.0LEP, INSR, INS
310.0INS, INSR, LEP
4
Hide members
10.0INSR, INS, IGF1R
510.0IGF1, INS, INSR
69.9SLC2A4, INSR, INS
7
Hide members
9.9ADIPOQ, SLC2A4, INSR
89.9SLC2A3, SLC2A4
9
Apoptosis and survival Caspase cascade
Hide members
9.9LMNA, IGF1, IGF1R
109.9ADIPOQ, SLC2A4, LEP
119.9ADIPOQ, SLC2A4, LEP
129.8FGFR2, FGFR3, TGFA
139.8INSR, FGFR3, FGFR2, IGF1R
14
Hide members
9.8INSR, FGFR3, FGFR2, IGF1R
159.8IGF1R, FGFR2, FGFR3, INSR
169.8SLC2A4, LEP, INSR, INS
179.8IGF1R, IGF1, INS, INSR
18
Hide members
9.8IGF1R, IGF1, INS, INSR
199.8IGF1R, IGF1, INS, INSR
20
Hide members
9.8INS, INSR, SLC2A4, ADIPOQ
219.7ADIPOQ, SLC2A4, LEP, INSR
229.7IGF1R, FGFR2, FGFR3, ADRB3
23
Hide members
9.7SLC2A4, SLC2A3, LMNA
24
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.7ADRB3, INSR, IGF1, IGF1R
259.6IGF1R, FGFR2, FGFR3, TGFA
269.6FGFR3, IGF1, IGF1R, GH1
27
Hide members
9.6IGF1R, IGF1, FGFR2, FGFR3, INSR
28
Hide members
9.6IGF1R, FGFR2, FGFR3, INSR, SLC2A4
299.5IGF1R, INS, INSR, SLC2A4, ADIPOQ
309.5IGF1R, FGFR2, FGFR3, INSR, TGFA
31
Hide members
9.4IGF1R, IGF1, FGFR2, FGFR3, INS, INSR
32
Hide members
9.4IGF1R, IGF1, FGFR2, FGFR3, INSR, SLC2A4
33
Hide members
9.3GH1, IGF1, FGFR2, FGFR3, TGFA
34
Hide members
9.3GH1, IGF1R, FGFR2, FGFR3, INSR, ADRB3
35
Hide members
9.3IGF1R, IGF1, FGFR2, FGFR3, INS, TGFA
36
Translation Insulin regulation of translation
Hide members
9.2GH1, IGF1R, IGF1, INS, INSR, SLC2A4
37
Hide members
9.2GH1, IGF1R, FGFR2, FGFR3, INSR, TGFA
389.2GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
39
Hide members
9.1GH1, IGF1R, IGF1, FGFR2, FGFR3, TGFA
40
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
41
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
42
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
43
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
44
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
45
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
46
Hide members
8.8SLC2A4, INSR, FGFR3, FGFR2, IGF1, IGF1R
47
Hide members
8.7GH1, IGF1R, IGF1, MC1R, FGFR2, FGFR3
48
Hide members
8.6GH1, TGFA, SLC2A4, SLC2A3, FGFR3, FGFR2
498.5ADIPOQ, BSCL2, GH1, AGPAT2, IGF1, INS

Compounds for genes affiliated with Acanthosis Nigricans

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6ADRB3
2cycloheximide4510.3SLC2A3
3dehydroepiandrosterone sulfate4510.3GH1, SHBG, CYP21A2
4gnrh4510.2CYP21A2, SHBG, GH1
5mecasermin45 1111.0INS, INSR, IGF1R, IGF1
6norepinephrine45 11 2411.9SLC2A4, ADRB3, CYP21A2, TGFA
7rosiglitazone45 50 29 11 2413.8LEP, INSR, INS, SLC2A4, SHBG, LMNA
8acipimox45 2910.8GH1, ADIPOQ, INS, IGF1, LEP
9cortisone45 2410.8IGF1, LEP, INS, GH1, CYP21A2
10oxandrolone45 1110.8INS, SHBG, GH1, IGF1
11aicar45 11 2411.7INSR, LEP, INS, SLC2A4, ADIPOQ, IGF1
12pioglitazone45 50 29 1112.7INS, SLC2A4, LEP, ADIPOQ, SHBG, INSR
13tamoxifen45 50 29 1112.6TGFA, FGFR2, SLC2A4, IGF1R, IGF1
14glibenclamide45 29 50 6012.6ADIPOQ, SLC2A4, LEP, INSR, INS, BAIAP2L1
15octreotide45 60 29 1112.6INSR, INS, IGF1R, GH1, ADIPOQ, IGF1
16clomiphene citrate459.6INSR, INS, CYP21A2, IGF1, IGF1R, SHBG
17dhea459.5SHBG, INS, GH1, CYP21A2, LEP, ADIPOQ
18glucose459.5CYP21A2, BAIAP2L1, IGF1, IGF1R, SLC2A4, INSR
19androstenedione45 2410.5IGF1, ADIPOQ, INS, CYP21A2, GH1, LEP
20acth459.5GH1, MC1R, IGF1, CYP21A2, LEP
21serine459.5LEP, LMNA, GH1, MC1R, FGFR3, ADIPOQ
2211beta-hydroxysteroid459.4ADIPOQ, SLC2A4, LEP, GH1, CYP21A2
23ly294002459.4LEP, INSR, IGF1R, ADIPOQ, TGFA, SLC2A4
24thyroxine45 2410.4INS, INSR, ADIPOQ, CYP21A2, SHBG, GH1
25ibmx45 29 6011.3IGF1, SLC2A4, INSR, INS, GH1, IGF1R
26glycerol45 11 2411.3GH1, SHBG, INS, INSR, LEP, SLC2A4
27hydrocortisone45 2 60 1112.2SHBG, INSR, ADIPOQ, INS, TGFA, IGF1
28progestin459.2INSR, IGF1, IGF1R, SHBG, ADIPOQ, TGFA
292-deoxyglucose45 1110.1SLC2A3, ADIPOQ, INSR, IGF1R, SLC2A4, IGF1
30dexamethasone45 50 29 1112.1SLC2A4, GH1, SHBG, ADRB3, ADIPOQ, INSR
31metformin45 50 1111.1INS, BAIAP2L1, IGF1, SHBG, INSR, LEP
32epinephrine45 11 2411.1TGFA, ADRB3, LEP, INSR, GH1, SHBG
33rapamycin459.0FGFR2, IGF1, IGF1R, INSR, INS, LEP
34dihydrotestosterone45 29 11 2412.0INSR, LEP, TGFA, ADIPOQ, GH1, SHBG
35wortmannin459.0LEP, INSR, INS, IGF1, SLC2A4, ADIPOQ
36h2o2459.0IGF1R, BAIAP2L1, MC1R, FGFR2, LEP, SLC2A4
37c-peptide459.0CYP21A2, INSR, LEP, ADIPOQ, IGF1R, SHBG
38pd 98,059459.0SLC2A4, IGF1, IGF1R, LEP, TGFA, GH1
39creatinine458.9SLC2A4, SHBG, IGF1, IGF1R, INS, ADIPOQ
40ribonucleic acid458.9FGFR2, SLC2A3, SLC2A4, GH1, IGF1R, IGF1
41vitamin d458.7TGFA, IGF1, MC1R, FGFR2, GH1, IGF1R
42genistein45 29 60 2 11 2413.7TGFA, SLC2A4, GH1, SHBG, IGF1R, IGF1
43phosphatidylinositol458.6INS, FGFR2, BAIAP2L1, INSR, IGF1, LEP
44glycogen45 249.6SLC2A3, INSR, INS, SLC2A4, IGF1R, ADIPOQ
45progesterone45 60 29 11 2412.6SLC2A4, TGFA, SLC2A3, LEP, FGFR2, CYP21A2
46testosterone45 60 11 2411.5ADIPOQ, INSR, INS, FGFR2, IGF1, SHBG
47alanine458.5TGFA, MC1R, GH1, SHBG, IGF1R, INS
48estradiol45 11 2410.5GH1, ADIPOQ, LEP, CYP21A2, TGFA, IGF1
49arginine458.1ADIPOQ, LMNA, ADRB3, TGFA, FGFR3, LEP
50lipid458.1LMNA, LEP, INSR, INS, SLC2A4, ADIPOQ

GO Terms for genes affiliated with Acanthosis Nigricans

Sources:
16Gene Ontology
See all sources

Cellular components related to Acanthosis Nigricans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IGF1, INS, LEP, ADIPOQ, TGFA, GH1
2integral to plasma membraneGO:0058879.0IGF1R, MC1R, FGFR2, FGFR3, INSR, SLC2A4
3extracellular regionGO:0055769.0ADIPOQ, GH1, SHBG, IGF1, FGFR2, FGFR3
4plasma membraneGO:0058867.6IGF1R, IGF1, BAIAP2L1, MC1R, FGFR2, FGFR3

Biological processes related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:06026710.5INSR, INS
2positive regulation of developmental growthGO:04863910.5LEP, INSR
3bone mineralization involved in bone maturationGO:03563010.4LEP, IGF1
4bone maturationGO:07097710.4FGFR3, GH1
5positive regulation of phospholipase activityGO:01051810.4FGFR2, FGFR3
6positive regulation of protein kinase A signaling cascadeGO:01073910.4ADIPOQ, MC1R
7positive regulation of glycolysisGO:04582110.4INSR, INS, IGF1
8lung lobe morphogenesisGO:06046310.4IGF1, FGFR2
9positive regulation of glycogen biosynthetic processGO:04572510.3IGF1, INS, INSR
10positive regulation of insulin receptor signaling pathwayGO:04662810.3INS, LEP
11exocrine pancreas developmentGO:03101710.3INSR, IGF1, IGF1R
12negative regulation of mitosisGO:04583910.3FGFR2, FGFR3
13peptidyl-tyrosine phosphorylationGO:01810810.3INSR, FGFR3, FGFR2
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:06052710.3IGF1, FGFR2
15negative regulation of gluconeogenesisGO:04572110.2ADIPOQ, INS
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2GH1, FGFR3, LEP
17lens fiber cell developmentGO:07030710.2FGFR3, FGFR2
18positive regulation of glucose importGO:04632610.2IGF1, INS, INSR, ADIPOQ
19cellular response to insulin stimulusGO:03286910.2ADIPOQ, SLC2A4, INSR
20brown fat cell differentiationGO:05087310.2ADRB3, ADIPOQ, SLC2A4
21positive regulation of DNA replicationGO:04574010.2IGF1R, IGF1, INS, INSR
22protein autophosphorylationGO:04677710.1IGF1R, FGFR2, FGFR3, INSR
23positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1GH1, IGF1, INS
24glucose homeostasisGO:04259310.1ADIPOQ, SLC2A4, INSR, INS
25response to vitamin EGO:03319710.1IGF1R, LEP
26phosphatidylinositol-mediated signalingGO:04801510.1IGF1R, IGF1, FGFR2, FGFR3
27MAPK cascadeGO:00016510.1TGFA, INS, FGFR3
28positive regulation of epithelial cell proliferationGO:05067910.1IGF1, FGFR2, TGFA
29positive regulation of mitosisGO:04584010.1IGF1, INS, INSR, TGFA
30insulin receptor signaling pathwayGO:00828610.1IGF1R, FGFR2, FGFR3, INS, INSR
31male sex determinationGO:03023810.0IGF1R, INSR
32positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0ADIPOQ, INS, IGF1, GH1
33positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0IGF1, GH1
34positive regulation of protein kinase B signaling cascadeGO:05189710.0IGF1R, IGF1, MC1R, INS, INSR
35glucose transportGO:0157589.8GH1, INS, SLC2A3, SLC2A4
36positive regulation of cellular protein metabolic processGO:0322709.8ADIPOQ, INS
37positive regulation of cell proliferationGO:0082849.7IGF1R, IGF1, FGFR2, FGFR3, INS, INSR
38positive regulation of MAPK cascadeGO:0434109.4ADRB3, IGF1R, IGF1, FGFR2, FGFR3, INS

Molecular functions related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin bindingGO:04355910.3IGF1R, INSR
2fibroblast growth factor-activated receptor activityGO:00500710.2FGFR2, FGFR3
3insulin-like growth factor receptor bindingGO:00515910.2IGF1, INS, INSR
4insulin receptor substrate bindingGO:04356010.1INSR, IGF1R
5insulin receptor bindingGO:00515810.1INS, IGF1, IGF1R
6insulin-like growth factor I bindingGO:03199410.0IGF1R, INSR
7protein tyrosine kinase activityGO:00471310.0IGF1R, FGFR2, FGFR3, INSR
8hormone activityGO:0051799.7ADIPOQ, LEP, INS, IGF1, GH1
9glucose transmembrane transporter activityGO:0053559.6SLC2A4, SLC2A3
10growth factor activityGO:0080839.6TGFA, LEP, IGF1, GH1
11protein bindingGO:0055157.8GH1, IGF1R, IGF1, MC1R, FGFR2, FGFR3

Products for genes affiliated with Acanthosis Nigricans

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Acanthosis Nigricans

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet