MCID: ACN002
MIFTS: 57

Acanthosis Nigricans malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acanthosis Nigricans

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Aliases & Descriptions for Acanthosis Nigricans:

Name: Acanthosis Nigricans 11 47 26 49 38 13 67
an - Acanthosis Nigricans 11
 
Keratosis Nigricans 11
an 47

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:3138
ICD1029 L83
SNOMED-CT61 402599005, 72129000
MeSH38 D000052
NCIt44 C26687

Summaries for Acanthosis Nigricans

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Wikipedia:70 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

MalaCards based summary: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and beare-stevenson cutis gyrata syndrome, and has symptoms including hyperkeratosis, hypohidrosis and hypertrichosis. An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Insulin-mediated glucose transport and Aldosterone-regulated sodium reabsorption. Affiliated tissues include skin, ovary and lung, and related mouse phenotypes are neoplasm and limbs/digits/tail.

Related Diseases for Acanthosis Nigricans

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Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome with acanthosis nigricans34.4FGFR2, FGFR3
2beare-stevenson cutis gyrata syndrome32.5FGFR2, FGFR3
3alstrom syndrome31.6ALMS1, INS, LEP
4lipodystrophy, familial partial, 231.1INS, LEP, LMNA
5obesity29.4ADIPOQ, ALMS1, INS, INSR, LEP, SHBG
6diabetes mellitus, insulin-resistant, with acanthosis nigricans12.4
7saddan12.2
8insulin-resistant acanthosis nigricans, type a12.2
9acanthosis nigricans with muscle cramps and acral enlargement12.2
10diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension12.1
11cutis gyratum acanthosis nigricans craniosynostosis12.0
12leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome12.0
13lelis syndrome11.9
14hair-an syndrome11.5
15retinitis pigmentosa, deafness, mental retardation, and hypogonadism11.0
16lipodystrophy, congenital generalized, type 111.0
17rabson-mendenhall syndrome11.0
18hirschsprung disease ganglioneuroblastoma10.5INS, INSR
19adenocarcinoma10.5
20hyperandrogenism10.5
21flnb-related disorders10.4FGFR2, FGFR3
22plasmalogens synthesis deficiency isolated10.4FGFR2, FGFR3
23trigonocephaly 110.4FGFR2, FGFR3
24mite infestation10.4FGFR2, FGFR3
25bladder cancer, somatic10.4FGFR2, FGFR3
26apert syndrome10.4FGFR2, FGFR3
27hypogonadotropic hypogonadism 2 with or without anosmia10.4FGFR2, FGFR3
28central nervous system leukemia10.4FGFR2, FGFR3
29crouzon syndrome10.4
30fetal methyl mercury syndrome10.4INS, INSR
31accommodative esotropia10.4FGFR2, FGFR3
32glucosidase acid-1,4-alpha deficiency10.4INS, INSR
33polycystic ovary syndrome10.3
34gastric adenocarcinoma10.3
35maturity-onset diabetes of the young, type 1010.3INS, SHBG
36thanatophoric dysplasia, type i10.2FGFR2, FGFR3
37achondroplasia10.2
38glaucomatocyclitic crisis10.2FGFR2, FGFR3
39hypertelorism, preauricular sinus, punctal pits, and deafness10.2INS, SHBG
40pure mitochondrial myopathy10.2ADIPOQ, LEP
41lung cancer10.2
42mycosis fungoides10.2
43antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
44hypochondroplasia10.1
45hepatitis10.1
46pemphigus10.1
47conjunctival vascular disease10.1INS, SHBG
48tenosynovial giant cell tumor10.1ADIPOQ, LEP
49potato nose10.1ADIPOQ, LEP
50hypothyroidism10.1

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Symptoms for Acanthosis Nigricans

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Human phenotypes related to Acanthosis Nigricans:

 63 (show all 8)
id Description HPO Frequency HPO Source Accession
1 hyperkeratosis63 hallmark (90%) HP:0000962
2 hypohidrosis63 typical (50%) HP:0000966
3 hypertrichosis63 typical (50%) HP:0000998
4 obesity63 typical (50%) HP:0001513
5 generalized hyperpigmentation63 typical (50%) HP:0007440
6 type ii diabetes mellitus63 occasional (7.5%) HP:0005978
7 cognitive impairment63 occasional (7.5%) HP:0100543
8 acanthosis nigricans63 HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

Drugs & Therapeutics for Acanthosis Nigricans

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Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminapprovedPhase 4, Phase 3, Phase 21746657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2Hypoglycemic AgentsPhase 4, Phase 3, Phase 25733
3insulinPhase 3, Phase 24524
4Insulin, Globin ZincPhase 3, Phase 24523
5AutoantibodiesPhase 3126
6
Leuprolideapproved, investigationalPhase 229353714-56-03911, 657181
Synonyms:
(D-Leu(6),des-gly-NH2(10),pro-ethylamide(9))-gonadotropin-releasing hormone
5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
AC1L1GZK
AC1L9B44
AC1Q5OPO
AR-1G9354
C07612
CID3911
CID441410
D00989
D08113
Enantone
Enantone (TN)
I04-0109
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
L001094
 
L002030
Leuprolide
Leuprolide acetate
Leuprolide acetate (USAN)
Leuprorelin
Leuprorelin (INN)
Leuprorelin acetate (JAN)
Leuprorelina
Leuproreline
Leuprorelinum
Lupron (TN)
N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
NSC377526
NSC746847
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-NHC2H5
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-nhet
acetic acid
leuprolide
7
SpironolactoneapprovedPhase 22221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
8
EnclomipheneinvestigationalPhase 216215690-57-0
Synonyms:
 
Clomiphene trans-form
9ZuclomiphenePhase 2162
10Estrogen Receptor ModulatorsPhase 2630
11EstrogensPhase 22470
12Natriuretic AgentsPhase 21645
13Estrogen AntagonistsPhase 21315
14ClomiphenePhase 2162
15Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
16Diuretics, Potassium SparingPhase 21827
17diureticsPhase 21372
18Antineoplastic Agents, HormonalPhase 25407
19Fertility AgentsPhase 2493
20Hormone AntagonistsPhase 212778
21Mineralocorticoid Receptor AntagonistsPhase 2333
22Selective Estrogen Receptor ModulatorsPhase 2586
23HormonesPhase 213979
24MineralocorticoidsPhase 2352
25CitrateNutraceuticalPhase 21106
26
Citric Acidnutraceutical, vet_approvedPhase 2110677-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
27
Pyridoxineapproved, nutraceutical, vet_approved18665-23-61054
Synonyms:
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
12001-78-4
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3-Hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
3-Hydroxy-4,5-dimethylol-alpha-picoline
3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol
4-Deoxypyridoxine 5'-phosphate
47862_SUPELCO
5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
58-56-0
58-56-0 (HCL)
58-56-0 (hydrochloride)
65-23-6
65-23-6 (Parent)
8059-24-3
85078-23-5
AC-12024
AC-14512
AC-907/25014218
AC1L1AMH
AC1L1LMI
AC1L2XK2
AC1Q22HP
AC1Q2G66
AC1Q3F63
AI3-19016
AIDS-006784
AIDS006784
AR-1A6363
AR-1J1632
Adermin hydrochloride
Adermine
Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Alestrol
BB_NC-0050
BIDD:PXR0180
BPBio1_000646
BSPBio_000586
Becilan
Beesix
Benadon
Bonasanit
C00314
C8H11NO3
CAS-58-56-0
CBDivE_015627
CCRIS 1903
CHEBI:16709
CHEBI:30961
CHEMBL1200756
CHEMBL1364
CID104817
CID1054
CID6019
CPD0-1221
Campoviton 6
Cernevit-12
D02179
D025101
D08454
DB00165
EINECS 200-386-2
EINECS 200-603-0
EINECS 232-503-8
Godabion
Gravidox
HMS1569N08
HMS2093L07
HSDB 1212
Hexa-Betalin
Hexa-Betalin (R)
Hexa-betalin (TN)
Hexabetalin
Hexabione hydrochloride
 
Hexavibex
Hexermin
Hexermine
Hexobion
Hydoxin
I02-1897
I02-2297
KST-1A8556
LS-134393
LS-187072
LS-2332
MLS001074329
MLS002153915
MolPort-002-137-856
MolPort-002-319-991
MolPort-005-933-330
NCGC00016261-01
NCGC00164317-01
NCGC00180946-01
NSC 36225
NSC36225
NSC36225 (HCL)
Nestrex
Oprea1_061614
P0561
P4722_SIAL
P5669_SIGMA
P6280_SIGMA
P8666_SIGMA
P9755_SIAL
PN
PN HCl
PYRIDOXINE HYDROCHLORIDE
PYRIDOXINE HYDROCHLORIDE, U.S.P.
Paxadon
Piridossina
Piridossina [DCIT]
Piridoxina
Piridoxina [INN-Spanish]
Prestwick0_000623
Prestwick1_000623
Prestwick2_000623
Prestwick3_000623
Prestwick_925
Pydox
Pyridipca
Pyridox
Pyridoxin
Pyridoxin hydrochloride
Pyridoxine
Pyridoxine (INN)
Pyridoxine HCl
Pyridoxine Hydrochloride (B6)
Pyridoxine [INN:BAN]
Pyridoxine chloride
Pyridoxine hydrochloride (JP15/USP)
Pyridoxine hydrochloride [USAN:JAN]
Pyridoxine hydrogen chloride
Pyridoxine monohydrochloride
Pyridoxine, hydrochloride
Pyridoxine-HCl Microencapsulated
Pyridoxinium chloride
Pyridoxinum
Pyridoxinum [INN-Latin]
Pyridoxinum hydrochloricum
Pyridoxinum hydrochloricum (Hungarian)
Pyridoxol
Pyridoxol hydrochloride
Pyridoxol, hydrochloride
Pyridoxolum
Rodex
Rodex (R)
Rodex TD
SMP2_000230
SMR000674613
SPBio_002805
STK177324
STOCK1N-08684
Spondylonal
Tex Six T.R.
TimTec1_000657
UNII-68Y4CF58BV
UNII-KV2JZ1BI6Z
Vitamin B 6
Vitamin B6
Vitamin B6-hydrochloride
Vitamin V6
Vitamin V6 (TN)
Vitamin-?B6
Vitamin-?B6 hydrochloride
Vitaped
WLN: T6NJ B1 CQ D1Q E1Q &GH
ZINC00049154
ZINC21983293
bmse000288
c1302
component of Alestrol
nchembio.93-comp1
pyridoxine
vitamin B6
28
Pyridoxalapproved, nutraceutical18566-72-81050
Synonyms:
2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde
 
3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
Piridoxal
Pyridoxal
Pyridoxaldehyde
29
Melatoninapproved, nutraceutical, vet_approved25573-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
30Vitamin B 6186
31Vitamins5095
32Vitamin B Complex4229
33Protective Agents7190
34Antioxidants2928
35Calcium, Dietary5525
36Central Nervous System Depressants12806

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With ObesityNot yet recruitingNCT02438020Phase 4
2Adjunctive Metformin Therapy in Double DiabetesCompletedNCT01334125Phase 3
3Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans SyndromeCompletedNCT00004311Phase 2
4Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome PatientsCompletedNCT02562664Phase 2
5Prevalence of Carbohydrate Intolerance in Lean and Obese ChildrenUnknown statusNCT00000112
6Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With HyperinsulinemiaCompletedNCT01125150
7Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid MetabolismCompletedNCT02604095

Search NIH Clinical Center for Acanthosis Nigricans


Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

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Genetic tests related to Acanthosis Nigricans:

id Genetic test Affiliating Genes
1 Acanthosis Nigricans26

Anatomical Context for Acanthosis Nigricans

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MalaCards organs/tissues related to Acanthosis Nigricans:

35
Skin, Ovary, Lung, Prostate, Liver, Thyroid, B cells

Animal Models for Acanthosis Nigricans or affiliated genes

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MGI Mouse Phenotypes related to Acanthosis Nigricans:

40 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ADIPOQ, FGFR2, FGFR3, IGF1R, LEP
2MP:00053718.6FGFR2, FGFR3, IGF1R, LEP, LMNA
3MP:00053778.4ALMS1, FGFR2, FGFR3, IGF1R, LMNA
4MP:00053917.9ALMS1, FGFR2, FGFR3, INS, LEP, LMNA
5MP:00053887.9ADIPOQ, FGFR2, FGFR3, IGF1R, INSR, LEP
6MP:00053697.8ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
7MP:00053907.8ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
8MP:00107717.7ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
9MP:00036317.7FGFR2, FGFR3, IGF1R, INS, INSR, LEP
10MP:00053817.5FGFR2, FGFR3, IGF1R, INS, INSR, LEP
11MP:00053857.4ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
12MP:00053977.3ADIPOQ, FGFR2, FGFR3, IGF1R, INS, INSR
13MP:00107687.3ADIPOQ, FGFR2, FGFR3, IGF1R, INS, INSR
14MP:00053897.2ALMS1, FGFR2, FGFR3, IGF1R, INS, INSR
15MP:00053797.0ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
16MP:00053707.0ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
17MP:00053846.6ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
18MP:00053756.6ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
19MP:00053876.6ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
20MP:00053676.5ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
21MP:00053866.5ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
22MP:00053786.5ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
23MP:00053766.4ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS

Publications for Acanthosis Nigricans

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Articles related to Acanthosis Nigricans:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges. (28031729)
2017
2
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. (27746646)
2016
3
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. (27167874)
2016
4
Unusual Presentation of Acanthosis Nigricans Associated With Metabolic Syndrome. (26861532)
2015
5
Differentiating confluent and reticulated papillomatosis from acanthosis nigricans. (26264983)
2015
6
Acanthosis nigricans in type 2 diabetes: prevalence, correlates and potential as a simple clinical screening tool - a cross-sectional study in the Caribbean. (25031628)
2014
7
Malignant acanthosis nigricans, florid cutaneous papillomatosis and tripe palms syndrome associated with gastric adenocarcinoma. (24683401)
2014
8
A case of hyperpigmentation and acanthosis nigricans by testosterone injections. (24505054)
2014
9
Coexistence of insulin-derived amyloidosis and an overlying acanthosis nigricans-like lesion at the site of insulin injection. (22924529)
2013
10
Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review. (22179051)
2012
11
Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children. (23329755)
2012
12
Prevalence of Acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome. (21276250)
2011
13
This is linear verrucous epidermal nevus, not acanthosis nigricans. (20036800)
2010
14
Acanthosis nigricans in a patient with sarcoma of unknown origin. (20159329)
2010
15
Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening. (20804685)
2010
16
Significance of acanthosis nigricans in childhood obesity. (18476925)
2008
17
Nevoid acanthosis nigricans with subtle melanocyte hyperplasia. (18489033)
2008
18
Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate. (17939948)
2007
19
Confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl: two distinct pathologies with a common pathogenetic pathway or a unique entity dependent on insulin resistance? (16643163)
2006
20
Generalized acanthosis nigricans in childhood. (17083894)
2006
21
Acanthosis nigricans as an adverse effect of highly active antiretroviral therapy in an adolescent girl with human immunodeficiency virus infection. (16094236)
2005
22
Eyelid involvement in acanthosis nigricans: the importance of systemic screening. (16234716)
2005
23
Facial acanthosis nigricans associated with obesity. (15953092)
2005
24
Acanthosis nigricans in a boy with achondroplasia due to the classical Gly380Arg mutation in FGFR3. (15517832)
2004
25
Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. (12553628)
2003
26
Association of acanthosis nigricans with race and metabolic disturbances in obese women. (11743615)
2002
27
Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome). (12457412)
2002
28
Tripe palms and malignant acanthosis nigricans: cutaneous signs of imminent metastasis in bladder cancer? (11342938)
2001
29
Microscopic acanthosis nigricans in type 2 diabetes. (11907848)
2001
30
A study of insulin resistance in subjects with acanthosis nigricans. (11573555)
2001
31
The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. (10696568)
2000
32
Association of Acanthosis nigricans with risk of diabetes mellitus and hormonal disturbances in females. (11102622)
2000
33
Crouzon syndrome with acanthosis nigricans: case report and mutational analysis. (10670894)
2000
34
Malignant acanthosis nigricans: potential role of chemotherapy. (10583123)
1999
35
Malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma--a case report and review of literature. (9190991)
1997
36
Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans. (9007703)
1996
37
Case report: defective beta and alpha cell regulation in patients with hyperinsulinemia and acanthosis nigricans. (8172227)
1994
38
Malignant acanthosis nigricans associated with a renal tumor. (8125695)
1993
39
Further evidence that acanthosis nigricans maligna is linked to enhanced secretion by the tumour of transforming growth factor alpha. (1444575)
1992
40
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990
41
Medical therapy for the syndrome of familial virilization, insulin resistance, and acanthosis nigricans. (2137793)
1990
42
Acanthosis nigricans associated with alveolar cell carcinoma. (2848329)
1988
43
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
44
Antibodies against the insulin receptor in paraneoplastic acanthosis nigricans. (3605142)
1987
45
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. (3900841)
1985
46
Insulin resistance, acanthosis nigricans, and polycystic ovaries associated with a circulating inhibitor of postbinding insulin action. (3884647)
1985
47
Acanthosis nigricans maligna. Clinical and virological investigations. (6086413)
1984
48
Insulin-resistant diabetes mellitus and insulin receptor antibodies: variable association with acanthosis nigricans. (7287512)
1980
49
Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans. (6989695)
1980
50
Cutaneous manifestation of internal malignancies (I). Acanthosis nigricans. (659033)
1978

Variations for Acanthosis Nigricans

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Expression for genes affiliated with Acanthosis Nigricans

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Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

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Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.8INS, INSR
29.8INS, INSR
39.8INS, INSR
49.4INS, INSR, LEP
5
Show member pathways
9.4INS, INSR, LEP
6
Show member pathways
9.4ADIPOQ, INS, INSR
7
Show member pathways
9.3IGF1R, INS, INSR
8
Show member pathways
9.3IGF1R, INS, INSR
99.3IGF1R, INS, INSR
109.3IGF1R, INS, INSR
119.3FGFR2, FGFR3, IGF1R
129.3ADIPOQ, INS, LEP
139.0FGFR2, FGFR3, IGF1R, INSR
149.0FGFR2, FGFR3, IGF1R, INSR
15
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
16
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
17
Show member pathways
9.0FGFR2, FGFR3, IGF1R, INSR
189.0FGFR2, FGFR3, IGF1R, INSR
198.8ADIPOQ, IGF1R, INS, INSR
20
Show member pathways
8.8ADIPOQ, IGF1R, INS, INSR
218.6ADIPOQ, INS, LEP, LMNA
22
Show member pathways
8.6FGFR2, FGFR3, IGF1R, INS, INSR
238.6FGFR2, FGFR3, IGF1R, INS, INSR
24
Show member pathways
8.6FGFR2, FGFR3, IGF1R, INS, INSR
25
Show member pathways
8.6ADIPOQ, FGFR2, FGFR3, INS, LEP
26
Show member pathways
8.2FGFR2, FGFR3, IGF1R, INS, INSR, LEP

GO Terms for genes affiliated with Acanthosis Nigricans

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Cellular components related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1ADIPOQ, FGFR2, FGFR3, INS, LEP, SHBG

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:004582110.5INS, INSR
2positive regulation of developmental growthGO:004863910.4INSR, LEP
3positive regulation of glycogen biosynthetic processGO:004572510.4INS, INSR
4positive regulation of respiratory burstGO:006026710.4INS, INSR
5activation of protein kinase B activityGO:003214810.4INS, INSR
6positive regulation of insulin receptor signaling pathwayGO:004662810.4INS, LEP
7positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.3FGFR3, LEP
8bone mineralizationGO:003028210.3FGFR2, FGFR3
9positive regulation of phospholipase activityGO:001051810.3FGFR2, FGFR3
10negative regulation of gluconeogenesisGO:004572110.2ADIPOQ, INS
11positive regulation of cellular protein metabolic processGO:003227010.2ADIPOQ, INS
12response to tumor necrosis factorGO:003461210.1ADIPOQ, INSR
13bone morphogenesisGO:006034910.1FGFR2, FGFR3
14regulation of protein localization to nucleusGO:190018010.1LEP, LMNA
15fatty acid beta-oxidationGO:000663510.0ADIPOQ, LEP
16insulin receptor signaling pathwayGO:00082869.9IGF1R, INS, INSR
17positive regulation of protein kinase B signalingGO:00518979.9INS, INSR, LEP
18peptidyl-tyrosine phosphorylationGO:00181089.9FGFR2, FGFR3, INSR
19positive regulation of glucose importGO:00463269.8ADIPOQ, INS, INSR
20phosphatidylinositol-mediated signalingGO:00480159.8FGFR2, FGFR3, IGF1R
21positive regulation of mitotic nuclear divisionGO:00458409.7INS, INSR
22positive regulation of DNA replicationGO:00457409.6IGF1R, INS, INSR
23glucose metabolic processGO:00060069.6ADIPOQ, INS, LEP
24regulation of fat cell differentiationGO:00455989.5ALMS1, LEP
25response to activityGO:00148239.4ADIPOQ, INSR, LEP
26positive regulation of cell migrationGO:00303359.4IGF1R, INS, INSR
27protein autophosphorylationGO:00467779.3FGFR2, FGFR3, IGF1R, INSR
28response to ethanolGO:00454719.3ADIPOQ, INSR, LEP
29positive regulation of MAPK cascadeGO:00434109.0FGFR2, FGFR3, INS, INSR, LEP
30glucose homeostasisGO:00425938.5ADIPOQ, ALMS1, INS, INSR, LEP
31positive regulation of cell proliferationGO:00082847.9FGFR2, FGFR3, IGF1R, INS, INSR, LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.4FGFR2, FGFR3
2insulin-like growth factor receptor bindingGO:000515910.3INS, INSR
3insulin-like growth factor I bindingGO:003199410.2IGF1R, INSR
4insulin receptor substrate bindingGO:004356010.1IGF1R, INSR
5insulin bindingGO:004355910.1IGF1R, INSR
6fibroblast growth factor bindingGO:001713410.0FGFR2, FGFR3
7phosphatidylinositol 3-kinase bindingGO:00435489.9IGF1R, INSR
8insulin receptor bindingGO:00051589.6IGF1R, INS
9hormone activityGO:00051799.5ADIPOQ, INS, LEP
10protein tyrosine kinase activityGO:00047139.1FGFR2, FGFR3, IGF1R, INSR

Sources for Acanthosis Nigricans

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet