AN
MCID: ACN002
MIFTS: 57

Acanthosis Nigricans (AN) malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acanthosis Nigricans

Aliases & Descriptions for Acanthosis Nigricans:

Name: Acanthosis Nigricans 12 50 29 52 42 14 69
an - Acanthosis Nigricans 12
Keratosis Nigricans 12
an 50

Characteristics:

HPO:

32
acanthosis nigricans:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:3138
ICD10 33 L83
MeSH 42 D000052
NCIt 47 C26687
SNOMED-CT 64 402599005 72129000
UMLS 69 C0000889

Summaries for Acanthosis Nigricans

NIH Rare Diseases : 50 acanthosis nigricans (an) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. the exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. last updated: 8/18/2014

MalaCards based summary : Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and hyperlipoproteinemia type iv, and has symptoms including pruritus An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are PEDF Induced Signaling and p70S6K Signaling. The drugs Metformin and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and lung, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 71 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Related Diseases for Acanthosis Nigricans

Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 crouzon syndrome with acanthosis nigricans 34.1 FGFR2 FGFR3
2 hyperlipoproteinemia type iv 29.8 ADIPOQ INS LEP
3 primary biliary cirrhosis 29.6 INS INSR LEP SHBG
4 diabetes mellitus, insulin-resistant, with acanthosis nigricans 12.4
5 saddan 12.2
6 insulin-resistant acanthosis nigricans, type a 12.2
7 acanthosis nigricans with muscle cramps and acral enlargement 12.2
8 diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension 12.1
9 leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome 12.0
10 cutis gyratum acanthosis nigricans craniosynostosis 12.0
11 hair-an syndrome 12.0
12 lelis syndrome 11.9
13 beare-stevenson cutis gyrata syndrome 11.8
14 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.0
15 lipodystrophy, congenital generalized, type 1 11.0
16 lipodystrophy, familial partial, 2 11.0
17 alstrom syndrome 11.0
18 rabson-mendenhall syndrome 11.0
19 obesity 10.7
20 adenocarcinoma 10.5
21 hyperandrogenism 10.5
22 crouzon syndrome 10.4
23 gastric adenocarcinoma 10.3
24 polycystic ovary syndrome 10.3
25 intellectual disability-developmental delay-contractures syndrome 10.3 INS INSR
26 achondroplasia 10.2
27 acrocephalopolydactyly 10.2 ADIPOQ LEP
28 autosomal recessive congenital ichthyosis 10.2 INS LEP
29 malignant perineurioma 10.2 ADIPOQ LEP
30 mycosis fungoides 10.2
31 hypochondroplasia 10.2
32 lung cancer 10.2
33 familial porphyria cutanea tarda 10.2 FGFR2 FGFR3
34 hartsfield syndrome 10.2 FGFR2 FGFR3
35 pointer syndrome 10.2 FGFR2 FGFR3
36 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.2 FGFR2 FGFR3
37 cervical spinal canal and spinal cord meningioma 10.1 FGFR2 FGFR3
38 osteoglophonic dysplasia 10.1 FGFR2 FGFR3
39 mucinoses 10.1 ADIPOQ LEP
40 squamous cell carcinoma 10.1
41 hepatitis 10.1
42 pemphigus 10.1
43 diabetes mellitus, insulin-dependent, 2 10.1 INS SHBG
44 fetal warfarin syndrome 10.1 INS INSR LEP
45 aica-ribosiduria due to atic deficiency 10.1 FGFR2 FGFR3
46 diarrhea 3, secretory sodium, congenital, syndromic 10.1 IGF1R INS INSR
47 hyperinsulinemic hypoglycemia, familial, 5 10.1 IGF1R INS INSR
48 muenke syndrome 10.1 FGFR2 FGFR3
49 hypothyroidism 10.1
50 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to Acanthosis Nigricans

Symptoms & Phenotypes for Acanthosis Nigricans

Human phenotypes related to Acanthosis Nigricans:

32
id Description HPO Frequency HPO Source Accession
1 acanthosis nigricans 32 HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

GenomeRNAi Phenotypes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 FGFR2 FGFR3 IGF1R INSR
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR2 FGFR3 INSR
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 INSR

MGI Mouse Phenotypes related to Acanthosis Nigricans:

44 (show all 23)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
2 cellular MP:0005384 10.24 FGFR2 FGFR3 IGF1R INS INSR LEP
3 growth/size/body region MP:0005378 10.22 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
4 adipose tissue MP:0005375 10.21 ADIPOQ ALMS1 FGFR2 IGF1R INS INSR
5 homeostasis/metabolism MP:0005376 10.19 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
6 endocrine/exocrine gland MP:0005379 10.18 ADIPOQ ALMS1 FGFR2 IGF1R INS INSR
7 immune system MP:0005387 10.18 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
8 hematopoietic system MP:0005397 10.15 ADIPOQ FGFR2 FGFR3 IGF1R INS INSR
9 cardiovascular system MP:0005385 10.14 ADIPOQ FGFR2 IGF1R INS INSR LEP
10 digestive/alimentary MP:0005381 10.13 FGFR2 FGFR3 IGF1R INS INSR LEP
11 liver/biliary system MP:0005370 10.08 ADIPOQ ALMS1 FGFR2 IGF1R INS INSR
12 mortality/aging MP:0010768 10.06 INSR LEP LMNA ADIPOQ FGFR2 FGFR3
13 integument MP:0010771 10.05 LMNA ADIPOQ FGFR2 FGFR3 IGF1R INS
14 muscle MP:0005369 9.98 ADIPOQ FGFR2 IGF1R INS INSR LEP
15 hearing/vestibular/ear MP:0005377 9.96 ALMS1 FGFR2 FGFR3 IGF1R LMNA
16 renal/urinary system MP:0005367 9.92 ADIPOQ ALMS1 FGFR2 FGFR3 INS INSR
17 nervous system MP:0003631 9.91 FGFR2 FGFR3 IGF1R INS INSR LEP
18 limbs/digits/tail MP:0005371 9.89 IGF1R LEP LMNA FGFR2 FGFR3
19 reproductive system MP:0005389 9.86 INSR LEP LMNA ALMS1 FGFR2 FGFR3
20 neoplasm MP:0002006 9.8 ADIPOQ FGFR2 FGFR3 IGF1R LEP
21 respiratory system MP:0005388 9.7 ADIPOQ FGFR2 FGFR3 IGF1R INSR LEP
22 skeleton MP:0005390 9.5 IGF1R INS LEP LMNA ADIPOQ FGFR2
23 vision/eye MP:0005391 9.1 ALMS1 FGFR2 FGFR3 INS LEP LMNA

Drugs & Therapeutics for Acanthosis Nigricans

Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
2 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Enclomiphene Investigational Phase 3,Phase 2 15690-57-0
5 Autoantibodies Phase 3
6 insulin Phase 3,Phase 2
7 Insulin, Globin Zinc Phase 3,Phase 2
8 Clomiphene Phase 3,Phase 2
9 Estrogen Antagonists Phase 3,Phase 2
10 Estrogen Receptor Modulators Phase 3,Phase 2
11 Estrogens Phase 3,Phase 2
12 Fertility Agents Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Selective Estrogen Receptor Modulators Phase 3,Phase 2
17 Zuclomiphene Phase 3,Phase 2
18 Aromatase Inhibitors Phase 3
19 Steroid Synthesis Inhibitors Phase 3
20
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
21
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
22 Antineoplastic Agents, Hormonal Phase 2
23 diuretics Phase 2
24 Diuretics, Potassium Sparing Phase 2
25 Mineralocorticoid Receptor Antagonists Phase 2
26 Mineralocorticoids Phase 2
27 Natriuretic Agents Phase 2
28 Citrate Nutraceutical Phase 2
29
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
30
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
31
Pyridoxal Approved, Nutraceutical 66-72-8 1050
32
Pyridoxine Approved, Nutraceutical, Vet_approved 65-23-6 1054
33 Antioxidants
34 Calcium, Dietary
35 Central Nervous System Depressants
36 Protective Agents
37 Vitamin B 6
38 Vitamin B Complex
39 Vitamins

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4
2 Adjunctive Metformin Therapy in Double Diabetes Completed NCT01334125 Phase 3
3 Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome Not yet recruiting NCT03135301 Phase 3
4 Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed NCT00004311 Phase 2
5 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2
6 Prevalence of Carbohydrate Intolerance in Lean and Obese Children Unknown status NCT00000112
7 Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia Completed NCT01125150
8 Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism Completed NCT02604095

Search NIH Clinical Center for Acanthosis Nigricans

Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

Genetic tests related to Acanthosis Nigricans:

id Genetic test Affiliating Genes
1 Acanthosis Nigricans 29

Anatomical Context for Acanthosis Nigricans

MalaCards organs/tissues related to Acanthosis Nigricans:

39
Skin, Ovary, Lung, Liver, Prostate, Thyroid, B Cells

Publications for Acanthosis Nigricans

Articles related to Acanthosis Nigricans:

(show top 50) (show all 575)
id Title Authors Year
1
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges. ( 28031729 )
2017
2
Mild achondroplasia/hypochondroplasia with acanthosis nigricans, normal development, and a p.Ser348Cys FGFR3 mutation. ( 28181399 )
2017
3
The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors. ( 28081576 )
2017
4
Unilateral nevoid acanthosis nigricans treated with CO2 laser. ( 27457822 )
2016
5
Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease. ( 27051830 )
2016
6
ACANTHOSIS NIGRICANS AND SEVERE INSULIN RESISTANCE IN A BOY WITH ATAXIA. ( 27124696 )
2016
7
Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial. ( 27999648 )
2016
8
A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR. ( 27990384 )
2016
9
A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism. ( 27505086 )
2016
10
FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. ( 27190511 )
2016
11
Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection. ( 27598021 )
2016
12
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. ( 27167874 )
2016
13
Acanthosis Nigricans associated with clear-cell renal cell carcinoma. ( 27284539 )
2016
14
IMAGES IN CLINICAL MEDICINE. Acanthosis Nigricans and Insulin Resistance. ( 27305209 )
2016
15
Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific. ( 27631218 )
2016
16
Lelis Syndrome: A Rare Cause of Acanthosis Nigricans. ( 27595879 )
2016
17
Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity. ( 26588491 )
2016
18
Bilaterally mammary acanthosis nigricans as paraneoplastic manifestation of prostate adenocarcinoma. ( 27595210 )
2016
19
Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR3 mutation. ( 26818779 )
2016
20
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. ( 27746646 )
2016
21
Acanthosis Nigricans as a Clinical Predictor of Insulin Resistance in Obese Children. ( 28090470 )
2016
22
Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans. ( 26860419 )
2016
23
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer. ( 27536145 )
2016
24
Linear acanthosis nigricans on the anterior neck: Koebner phenomenon observed in a patient with acanthosis nigricans. ( 27569660 )
2016
25
Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: a case report. ( 27987313 )
2016
26
Acanthosis nigricans in insulinoma: before and after successful surgical enucleation. ( 27836838 )
2016
27
A case of acanthosis nigricans coexisting with mycosis fungoides. ( 26436975 )
2015
28
Unilateral nevoid acanthosis nigricans. ( 26123470 )
2015
29
Oral Malignant Acanthosis Nigricans and Tripe Palms Associated With Renal Urothelial Carcinoma. ( 26309230 )
2015
30
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. ( 25657419 )
2015
31
Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. ( 25817595 )
2015
32
Association of the Family Nutrition and Physical Activity Screening Tool with Weight Status, Percent Body Fat, and Acanthosis Nigricans in Children from a Low Socioeconomic, Urban Community. ( 26675805 )
2015
33
Familial hypochondroplasia and acanthosis nigricans with FGFR3 K650T mutation. ( 25809207 )
2015
34
Differentiating confluent and reticulated papillomatosis from acanthosis nigricans. ( 26264983 )
2015
35
Acral Acanthosis Nigricans in a Case of Scleroderma. ( 26288450 )
2015
36
Paraneoplastic acanthosis nigricans: the first reported case associated with a SAczary syndrome. ( 26264676 )
2015
37
Perioral Acanthosis nigricans. ( 26388207 )
2015
38
Costello syndrome with severe nodulocystic acne: unexpected significant improvement of acanthosis nigricans after oral isotretinoin treatment. ( 25815234 )
2015
39
Social anxiety, depression and self-esteem in obese adolescent girls with acanthosis nigricans. ( 25800478 )
2015
40
Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome. ( 26229697 )
2015
41
Florid cutaneous manifestations with acanthosis nigricans in a lung cancer patient. ( 25734371 )
2015
42
Regression of Acanthosis Nigricans with the Addition of Sitagliptin and Pioglitazone. ( 26360673 )
2015
43
Acanthosis nigricans: A fold (intertriginous) dermatosis. ( 26051063 )
2015
44
Unusual Presentation of Acanthosis Nigricans Associated With Metabolic Syndrome. ( 26861532 )
2015
45
Evaluation of depressive symptoms in obese patients with or without acanthosis nigricans. ( 26188226 )
2015
46
Oral malignant acanthosis nigricans associated with endometrial adenocarcinoma. ( 24406633 )
2014
47
Malignant acanthosis nigricans associated with prostate cancer: a case report. ( 25399333 )
2014
48
Generalized benign acanthosis nigricans in an infant. ( 25593799 )
2014
49
Acral acanthosis nigricans (acral acanthotic anomaly). ( 25593810 )
2014
50
Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease. ( 25506563 )
2014

Variations for Acanthosis Nigricans

ClinVar genetic disease variations for Acanthosis Nigricans:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FGFR3 NM_000142.4(FGFR3): c.1948A> C (p.Lys650Gln) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889

Expression for Acanthosis Nigricans

Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for Acanthosis Nigricans

Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 FGFR2 FGFR3 IGF1R INS INSR LEP
2
Show member pathways
12.84 FGFR2 FGFR3 IGF1R INS INSR
3
Show member pathways
12.68 FGFR2 FGFR3 IGF1R INSR
4
Show member pathways
12.61 ADIPOQ INS INSR LEP
5
Show member pathways
12.54 FGFR2 FGFR3 INS INSR
6
Show member pathways
12.52 FGFR2 FGFR3 IGF1R INS INSR
7 12.3 ADIPOQ IGF1R INS INSR
8
Show member pathways
12.25 FGFR2 FGFR3 IGF1R INSR
9 12.25 FGFR2 FGFR3 IGF1R INS INSR
10
Show member pathways
12.03 INS INSR LEP
11
Show member pathways
12.02 FGFR2 FGFR3 IGF1R INS INSR
12
Show member pathways
11.97 FGFR2 FGFR3 IGF1R INSR
13 11.93 FGFR2 FGFR3 IGF1R
14
Show member pathways
11.92 IGF1R INS INSR
15
Show member pathways
11.91 ADIPOQ IGF1R INS INSR
16
Show member pathways
11.86 IGF1R INS INSR
17 11.86 FGFR2 FGFR3 IGF1R INSR
18 11.79 ADIPOQ INS LEP LMNA
19
Show member pathways
11.77 ADIPOQ IGF1R INS INSR LEP
20 11.76 IGF1R INS INSR
21 11.73 ADIPOQ INS LEP
22
Show member pathways
11.73 ADIPOQ INS INSR
23 11.54 FGFR2 FGFR3 IGF1R INSR
24 11.39 IGF1R INS INSR
25 11.37 INS INSR LEP
26 11.21 INS INSR
27 11.1 INS INSR
28 11.03 ADIPOQ LEP
29 10.78 ADIPOQ INSR LEP
30 10.58 FGFR2 FGFR3 IGF1R INSR

GO Terms for Acanthosis Nigricans

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.94 FGFR2 FGFR3 IGF1R INSR
2 positive regulation of cell migration GO:0030335 9.79 IGF1R INS INSR
3 response to ethanol GO:0045471 9.75 ADIPOQ FGFR2 LEP
4 phosphatidylinositol-mediated signaling GO:0048015 9.73 FGFR2 FGFR3 IGF1R
5 positive regulation of protein kinase B signaling GO:0051897 9.72 INS INSR LEP
6 insulin receptor signaling pathway GO:0008286 9.7 IGF1R INS INSR
7 glucose metabolic process GO:0006006 9.67 ADIPOQ INS LEP
8 protein autophosphorylation GO:0046777 9.67 FGFR2 FGFR3 IGF1R INSR
9 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.65 FGFR3 LEP
10 bone mineralization GO:0030282 9.64 FGFR2 FGFR3
11 bone morphogenesis GO:0060349 9.63 FGFR2 FGFR3
12 activation of protein kinase B activity GO:0032148 9.63 INS INSR
13 positive regulation of cell proliferation GO:0008284 9.63 FGFR2 FGFR3 IGF1R INS INSR LEP
14 positive regulation of mitotic nuclear division GO:0045840 9.62 INS INSR
15 peptidyl-tyrosine phosphorylation GO:0018108 9.62 FGFR2 FGFR3 IGF1R INSR
16 positive regulation of cellular protein metabolic process GO:0032270 9.61 ADIPOQ INS
17 regulation of fat cell differentiation GO:0045598 9.61 ALMS1 LEP
18 positive regulation of glycogen biosynthetic process GO:0045725 9.6 INS INSR
19 positive regulation of glycolytic process GO:0045821 9.59 INS INSR
20 negative regulation of gluconeogenesis GO:0045721 9.58 ADIPOQ INS
21 positive regulation of DNA replication GO:0045740 9.58 IGF1R INS INSR
22 positive regulation of insulin receptor signaling pathway GO:0046628 9.57 INS LEP
23 positive regulation of phospholipase activity GO:0010518 9.54 FGFR2 FGFR3
24 endochondral bone growth GO:0003416 9.51 FGFR2 FGFR3
25 regulation of protein localization to nucleus GO:1900180 9.48 LEP LMNA
26 positive regulation of respiratory burst GO:0060267 9.46 INS INSR
27 positive regulation of developmental growth GO:0048639 9.43 INSR LEP
28 positive regulation of glucose import GO:0046326 9.43 ADIPOQ INS INSR
29 glucose homeostasis GO:0042593 9.35 ADIPOQ ALMS1 INS INSR LEP
30 positive regulation of MAPK cascade GO:0043410 9.02 FGFR2 FGFR3 INS INSR LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.8 FGFR2 FGFR3 IGF1R INSR
2 insulin receptor binding GO:0005158 9.51 IGF1R INS
3 hormone activity GO:0005179 9.5 ADIPOQ INS LEP
4 fibroblast growth factor binding GO:0017134 9.48 FGFR2 FGFR3
5 phosphatidylinositol 3-kinase binding GO:0043548 9.46 IGF1R INSR
6 insulin-like growth factor receptor binding GO:0005159 9.43 INS INSR
7 insulin receptor substrate binding GO:0043560 9.4 IGF1R INSR
8 insulin-like growth factor I binding GO:0031994 9.37 IGF1R INSR
9 insulin binding GO:0043559 9.26 IGF1R INSR
10 protein tyrosine kinase activity GO:0004713 9.26 FGFR2 FGFR3 IGF1R INSR
11 fibroblast growth factor-activated receptor activity GO:0005007 9.16 FGFR2 FGFR3
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 FGFR2 FGFR3 IGF1R INSR

Sources for Acanthosis Nigricans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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