MCID: ACN002
MIFTS: 59

Acanthosis Nigricans malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acanthosis Nigricans

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Aliases & Descriptions for Acanthosis Nigricans:

Name: Acanthosis Nigricans 11 46 13 25 48 37 66
an - Acanthosis Nigricans 11
 
Keratosis Nigricans 11
an 46

Characteristics:



Classifications:



External Ids:

Disease Ontology11 DOID:3138
ICD1028 L83
SNOMED-CT60 402599005, 72129000
MeSH37 D000052
NCIt43 C26687

Summaries for Acanthosis Nigricans

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NIH Rare Diseases:46 Acanthosis nigricans (an) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. the exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. last updated: 8/18/2014

MalaCards based summary: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and beare-stevenson cutis gyrata syndrome, and has symptoms including hyperkeratosis, hypohidrosis and hypertrichosis. An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Insulin-mediated glucose transport and Signaling events mediated by TCPTP. Affiliated tissues include skin, ovary and lung, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Wikipedia:69 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Related Diseases for Acanthosis Nigricans

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Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome with acanthosis nigricans34.6FGFR2, FGFR3
2beare-stevenson cutis gyrata syndrome33.1FGFR2, FGFR3
3lipodystrophy, familial partial, 230.8INS, LEP
4alstrom syndrome30.2ALMS1, INS, LEP
5adrenal carcinoma30.0INS, PRL
6obesity28.6ADIPOQ, ALMS1, INS, INSR, LEP, PRL
7diabetes mellitus, insulin-resistant, with acanthosis nigricans12.4
8insulin-resistant acanthosis nigricans, type a12.3
9acanthosis nigricans with muscle cramps and acral enlargement12.3
10diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension12.2
11saddan12.1
12cutis gyratum acanthosis nigricans craniosynostosis12.1
13leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome12.1
14lelis syndrome11.8
15hair-an syndrome11.8
16retinitis pigmentosa, deafness, mental retardation, and hypogonadism11.2
17adenocarcinoma10.6
18hyperandrogenism10.6
19hirschsprung disease ganglioneuroblastoma10.6INS, INSR
20flnb-related disorders10.5FGFR2, FGFR3
21plasmalogens synthesis deficiency isolated10.5FGFR2, FGFR3
22trigonocephaly 110.5FGFR2, FGFR3
23mite infestation10.5FGFR2, FGFR3
24bladder cancer, somatic10.5FGFR2, FGFR3
25apert syndrome10.5FGFR2, FGFR3
26acute hydrops keratoconus10.5FGFR3, INS
27crouzon syndrome10.5
28hypogonadotropic hypogonadism 2 with or without anosmia10.5FGFR2, FGFR3
29central nervous system leukemia10.5FGFR2, FGFR3
30accommodative esotropia10.5FGFR2, FGFR3
31fetal methyl mercury syndrome10.5INS, INSR
32glucosidase acid-1,4-alpha deficiency10.5INS, INSR
33thanatophoric dysplasia, type i10.4FGFR2, FGFR3
34polycystic ovary syndrome10.4
35gastric adenocarcinoma10.4
36antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.4FGFR2, FGFR3
37achondroplasia10.3
38lung cancer10.3
39mycosis fungoides10.3
40secondary syphilis10.3IGF1R, INSR
41bardet-biedl syndrome10.3INS, PRL
42retinal microaneurysm10.3INS, PRL
43postpartum depression10.3INS, PRL
44hypochondroplasia10.3
45hepatitis10.3
46pemphigus10.3
47hypothalamic neoplasm10.3INS, PRL
48hemiplegia alterans10.3INS, PRL
49central retinal vein occlusion10.2INS, PRL
50hypothyroidism10.2

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Symptoms for Acanthosis Nigricans

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HPO human phenotypes related to Acanthosis Nigricans:

(show all 8)
id Description Frequency HPO Source Accession
1 hyperkeratosis hallmark (90%) HP:0000962
2 hypohidrosis typical (50%) HP:0000966
3 hypertrichosis typical (50%) HP:0000998
4 obesity typical (50%) HP:0001513
5 generalized hyperpigmentation typical (50%) HP:0007440
6 type ii diabetes mellitus occasional (7.5%) HP:0005978
7 cognitive impairment occasional (7.5%) HP:0100543
8 acanthosis nigricans HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

Drugs & Therapeutics for Acanthosis Nigricans

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Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminPhase 4, Phase 3, Phase 21701657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2insulinPhase 3, Phase 24401
3
Citric AcidPhase 2106377-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
4CLOMIPHENEPhase 2161
5
LeuprolidePhase 228453714-56-03911, 657181
Synonyms:
(D-Leu(6),des-gly-NH2(10),pro-ethylamide(9))-gonadotropin-releasing hormone
5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
AC1L1GZK
AC1L9B44
AC1Q5OPO
AR-1G9354
C07612
CID3911
CID441410
D00989
D08113
Enantone
Enantone (TN)
I04-0109
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
L001094
 
L002030
Leuprolide
Leuprolide acetate
Leuprolide acetate (USAN)
Leuprorelin
Leuprorelin (INN)
Leuprorelin acetate (JAN)
Leuprorelina
Leuproreline
Leuprorelinum
Lupron (TN)
N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
NSC377526
NSC746847
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-NHC2H5
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-nhet
acetic acid
leuprolide
6diureticsPhase 21338
7
EnclomiphenePhase 216115690-57-0
Synonyms:
 
Clomiphene trans-form
8
SpironolactonePhase 22171952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
9CitrateNutraceuticalPhase 21063
10
PyridoxineNutraceutical18065-23-61054
Synonyms:
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
12001-78-4
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3-Hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
3-Hydroxy-4,5-dimethylol-alpha-picoline
3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol
4-Deoxypyridoxine 5'-phosphate
47862_SUPELCO
5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
58-56-0
58-56-0 (HCL)
58-56-0 (hydrochloride)
65-23-6
65-23-6 (Parent)
8059-24-3
85078-23-5
AC-12024
AC-14512
AC-907/25014218
AC1L1AMH
AC1L1LMI
AC1L2XK2
AC1Q22HP
AC1Q2G66
AC1Q3F63
AI3-19016
AIDS-006784
AIDS006784
AR-1A6363
AR-1J1632
Adermin hydrochloride
Adermine
Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Alestrol
BB_NC-0050
BIDD:PXR0180
BPBio1_000646
BSPBio_000586
Becilan
Beesix
Benadon
Bonasanit
C00314
C8H11NO3
CAS-58-56-0
CBDivE_015627
CCRIS 1903
CHEBI:16709
CHEBI:30961
CHEMBL1200756
CHEMBL1364
CID104817
CID1054
CID6019
CPD0-1221
Campoviton 6
Cernevit-12
D02179
D025101
D08454
DB00165
EINECS 200-386-2
EINECS 200-603-0
EINECS 232-503-8
Godabion
Gravidox
HMS1569N08
HMS2093L07
HSDB 1212
Hexa-Betalin
Hexa-Betalin (R)
Hexa-betalin (TN)
Hexabetalin
Hexabione hydrochloride
 
Hexavibex
Hexermin
Hexermine
Hexobion
Hydoxin
I02-1897
I02-2297
KST-1A8556
LS-134393
LS-187072
LS-2332
MLS001074329
MLS002153915
MolPort-002-137-856
MolPort-002-319-991
MolPort-005-933-330
NCGC00016261-01
NCGC00164317-01
NCGC00180946-01
NSC 36225
NSC36225
NSC36225 (HCL)
Nestrex
Oprea1_061614
P0561
P4722_SIAL
P5669_SIGMA
P6280_SIGMA
P8666_SIGMA
P9755_SIAL
PN
PN HCl
PYRIDOXINE HYDROCHLORIDE
PYRIDOXINE HYDROCHLORIDE, U.S.P.
Paxadon
Piridossina
Piridossina [DCIT]
Piridoxina
Piridoxina [INN-Spanish]
Prestwick0_000623
Prestwick1_000623
Prestwick2_000623
Prestwick3_000623
Prestwick_925
Pydox
Pyridipca
Pyridox
Pyridoxin
Pyridoxin hydrochloride
Pyridoxine
Pyridoxine (INN)
Pyridoxine HCl
Pyridoxine Hydrochloride (B6)
Pyridoxine [INN:BAN]
Pyridoxine chloride
Pyridoxine hydrochloride (JP15/USP)
Pyridoxine hydrochloride [USAN:JAN]
Pyridoxine hydrogen chloride
Pyridoxine monohydrochloride
Pyridoxine, hydrochloride
Pyridoxine-HCl Microencapsulated
Pyridoxinium chloride
Pyridoxinum
Pyridoxinum [INN-Latin]
Pyridoxinum hydrochloricum
Pyridoxinum hydrochloricum (Hungarian)
Pyridoxol
Pyridoxol hydrochloride
Pyridoxol, hydrochloride
Pyridoxolum
Rodex
Rodex (R)
Rodex TD
SMP2_000230
SMR000674613
SPBio_002805
STK177324
STOCK1N-08684
Spondylonal
Tex Six T.R.
TimTec1_000657
UNII-68Y4CF58BV
UNII-KV2JZ1BI6Z
Vitamin B 6
Vitamin B6
Vitamin B6-hydrochloride
Vitamin V6
Vitamin V6 (TN)
Vitamin-?B6
Vitamin-?B6 hydrochloride
Vitaped
WLN: T6NJ B1 CQ D1Q E1Q &GH
ZINC00049154
ZINC21983293
bmse000288
c1302
component of Alestrol
nchembio.93-comp1
pyridoxine
vitamin B6
11
PyridoxalNutraceutical17966-72-81050
Synonyms:
2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde
 
3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
Piridoxal
Pyridoxal
Pyridoxaldehyde
12
MelatoninNutraceutical24573-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With ObesityNot yet recruitingNCT02438020Phase 4
2Adjunctive Metformin Therapy in Double DiabetesCompletedNCT01334125Phase 3
3Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans SyndromeCompletedNCT00004311Phase 2
4Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome PatientsCompletedNCT02562664Phase 2
5Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With HyperinsulinemiaCompletedNCT01125150
6Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid MetabolismCompletedNCT02604095
7Prevalence of Carbohydrate Intolerance in Lean and Obese ChildrenRecruitingNCT00000112

Search NIH Clinical Center for Acanthosis Nigricans


Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

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Genetic tests related to Acanthosis Nigricans:

id Genetic test Affiliating Genes
1 Acanthosis Nigricans25

Anatomical Context for Acanthosis Nigricans

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MalaCards organs/tissues related to Acanthosis Nigricans:

34
Skin, Ovary, Lung, Prostate, Liver, Thyroid, B cells

Animal Models for Acanthosis Nigricans or affiliated genes

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MGI Mouse Phenotypes related to Acanthosis Nigricans:

39 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3ALMS1, FGFR2, FGFR3, IGF1R
2MP:00053918.6ALMS1, FGFR2, FGFR3, INS, LEP
3MP:00053818.3FGFR2, FGFR3, IGF1R, INS, INSR, LEP
4MP:00053887.9ADIPOQ, FGFR2, FGFR3, IGF1R, INSR, LEP
5MP:00053697.9ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
6MP:00053857.7ADIPOQ, FGFR2, IGF1R, INS, INSR, LEP
7MP:00020067.6ADIPOQ, FGFR2, FGFR3, IGF1R, LEP, PRL
8MP:00036317.6FGFR2, FGFR3, IGF1R, INS, INSR, LEP
9MP:00053977.5ADIPOQ, FGFR2, FGFR3, IGF1R, INS, INSR
10MP:00053907.5ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
11MP:00107717.4ADIPOQ, FGFR2, FGFR3, IGF1R, INS, LEP
12MP:00053677.4ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
13MP:00053757.3ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
14MP:00053897.3ALMS1, FGFR2, FGFR3, IGF1R, INS, INSR
15MP:00053847.1ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
16MP:00053706.9ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
17MP:00053786.7ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
18MP:00053796.6ADIPOQ, ALMS1, FGFR2, IGF1R, INS, INSR
19MP:00053876.5ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
20MP:00053866.0ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS
21MP:00053765.8ADIPOQ, ALMS1, FGFR2, FGFR3, IGF1R, INS

Publications for Acanthosis Nigricans

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Articles related to Acanthosis Nigricans:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. (27167874)
2016
2
Unusual Presentation of Acanthosis Nigricans Associated With Metabolic Syndrome. (26861532)
2015
3
Differentiating confluent and reticulated papillomatosis from acanthosis nigricans. (26264983)
2015
4
Acanthosis nigricans in type 2 diabetes: prevalence, correlates and potential as a simple clinical screening tool - a cross-sectional study in the Caribbean. (25031628)
2014
5
Malignant acanthosis nigricans, florid cutaneous papillomatosis and tripe palms syndrome associated with gastric adenocarcinoma. (24683401)
2014
6
A case of hyperpigmentation and acanthosis nigricans by testosterone injections. (24505054)
2014
7
Coexistence of insulin-derived amyloidosis and an overlying acanthosis nigricans-like lesion at the site of insulin injection. (22924529)
2013
8
Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review. (22179051)
2012
9
Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children. (23329755)
2012
10
Prevalence of Acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome. (21276250)
2011
11
This is linear verrucous epidermal nevus, not acanthosis nigricans. (20036800)
2010
12
Acanthosis nigricans in a patient with sarcoma of unknown origin. (20159329)
2010
13
Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening. (20804685)
2010
14
Evaluation of insulin resistance in obese women with and without acanthosis nigricans. (19348659)
2009
15
Significance of acanthosis nigricans in childhood obesity. (18476925)
2008
16
Nevoid acanthosis nigricans with subtle melanocyte hyperplasia. (18489033)
2008
17
Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate. (17939948)
2007
18
Confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl: two distinct pathologies with a common pathogenetic pathway or a unique entity dependent on insulin resistance? (16643163)
2006
19
Generalized acanthosis nigricans in childhood. (17083894)
2006
20
Acanthosis nigricans as an adverse effect of highly active antiretroviral therapy in an adolescent girl with human immunodeficiency virus infection. (16094236)
2005
21
Eyelid involvement in acanthosis nigricans: the importance of systemic screening. (16234716)
2005
22
Facial acanthosis nigricans associated with obesity. (15953092)
2005
23
Acanthosis nigricans in a boy with achondroplasia due to the classical Gly380Arg mutation in FGFR3. (15517832)
2004
24
Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. (12553628)
2003
25
Association of acanthosis nigricans with race and metabolic disturbances in obese women. (11743615)
2002
26
Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome). (12457412)
2002
27
Tripe palms and malignant acanthosis nigricans: cutaneous signs of imminent metastasis in bladder cancer? (11342938)
2001
28
Microscopic acanthosis nigricans in type 2 diabetes. (11907848)
2001
29
A study of insulin resistance in subjects with acanthosis nigricans. (11573555)
2001
30
The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. (10696568)
2000
31
Association of Acanthosis nigricans with risk of diabetes mellitus and hormonal disturbances in females. (11102622)
2000
32
Crouzon syndrome with acanthosis nigricans: case report and mutational analysis. (10670894)
2000
33
Malignant acanthosis nigricans: potential role of chemotherapy. (10583123)
1999
34
Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. (10377013)
1999
35
Malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma--a case report and review of literature. (9190991)
1997
36
Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans. (9007703)
1996
37
Case report: defective beta and alpha cell regulation in patients with hyperinsulinemia and acanthosis nigricans. (8172227)
1994
38
Malignant acanthosis nigricans associated with a renal tumor. (8125695)
1993
39
Further evidence that acanthosis nigricans maligna is linked to enhanced secretion by the tumour of transforming growth factor alpha. (1444575)
1992
40
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990
41
Medical therapy for the syndrome of familial virilization, insulin resistance, and acanthosis nigricans. (2137793)
1990
42
Acanthosis nigricans associated with alveolar cell carcinoma. (2848329)
1988
43
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
44
Antibodies against the insulin receptor in paraneoplastic acanthosis nigricans. (3605142)
1987
45
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. (3900841)
1985
46
Insulin resistance, acanthosis nigricans, and polycystic ovaries associated with a circulating inhibitor of postbinding insulin action. (3884647)
1985
47
Acanthosis nigricans maligna. Clinical and virological investigations. (6086413)
1984
48
Insulin-resistant diabetes mellitus and insulin receptor antibodies: variable association with acanthosis nigricans. (7287512)
1980
49
Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans. (6989695)
1980
50
Cutaneous manifestation of internal malignancies (I). Acanthosis nigricans. (659033)
1978

Variations for Acanthosis Nigricans

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Expression for genes affiliated with Acanthosis Nigricans

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Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

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Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathwaysScoreTop Affiliating Genes
19.8INS, INSR
29.8INS, INSR
39.8INS, INSR
49.8INS, INSR
59.7FGFR2, FGFR3
6
Show member pathways
9.2INS, INSR, LEP
7
Show member pathways
9.2IGF1R, INS, INSR
8
Show member pathways
9.2IGF1R, INS, INSR
99.2IGF1R, INS, INSR
109.2IGF1R, INS, INSR
119.2FGFR2, FGFR3, IGF1R
129.2FGFR2, FGFR3, IGF1R
13
Show member pathways
9.0FGFR2, FGFR3, INS, INSR
14
Show member pathways
9.0INS, LEP, PRL
15
Show member pathways
8.9ADIPOQ, INS, INSR
16
Show member pathways
8.9FGFR2, FGFR3, IGF1R, INSR
17
Show member pathways
8.9FGFR2, FGFR3, IGF1R, INSR
188.9FGFR2, FGFR3, IGF1R, INSR
19
Show member pathways
8.9FGFR2, FGFR3, IGF1R, INSR
208.9FGFR2, FGFR3, IGF1R, INSR
21
Show member pathways
8.9FGFR2, FGFR3, IGF1R, INSR
22
Show member pathways
8.9FGFR2, FGFR3, IGF1R, INSR
238.9FGFR2, FGFR3, IGF1R, INSR
248.8ADIPOQ, INS, LEP
258.8ADIPOQ, INS, LEP
268.6INS, INSR, LEP, PRL
27
Show member pathways
8.5FGFR2, FGFR3, IGF1R, INS, INSR
28
Show member pathways
8.5FGFR2, FGFR3, IGF1R, INS, INSR
29
Show member pathways
8.4ADIPOQ, INS, INSR, LEP
30
Show member pathways
8.4ADIPOQ, INS, INSR, LEP
318.4ADIPOQ, IGF1R, INS, INSR
32
Show member pathways
8.4ADIPOQ, IGF1R, INS, INSR
33
Show member pathways
8.0ADIPOQ, FGFR2, FGFR3, INS, LEP
34
Show member pathways
7.9ADIPOQ, IGF1R, INS, INSR, LEP
35
Show member pathways
7.9FGFR2, FGFR3, IGF1R, INS, INSR, PRL
367.9FGFR2, FGFR3, IGF1R, INS, INSR, PRL
37
Show member pathways
7.4FGFR2, FGFR3, IGF1R, INS, INSR, LEP

GO Terms for genes affiliated with Acanthosis Nigricans

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Cellular components related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.4ADIPOQ, FGFR2, FGFR3, INS, LEP, PRL

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:004582110.4INS, INSR
2positive regulation of glycogen biosynthetic processGO:004572510.4INS, INSR
3positive regulation of respiratory burstGO:006026710.4INS, INSR
4activation of protein kinase B activityGO:003214810.4INS, INSR
5positive regulation of insulin receptor signaling pathwayGO:004662810.3INS, LEP
6positive regulation of phospholipase activityGO:001051810.2FGFR2, FGFR3
7positive regulation of developmental growthGO:004863910.2INSR, LEP
8positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2FGFR3, LEP
9bone mineralizationGO:003028210.1FGFR2, FGFR3
10positive regulation of nitric oxide biosynthetic processGO:004542910.1INS, INSR
11peptidyl-tyrosine autophosphorylationGO:003808310.0IGF1R, INSR
12bone morphogenesisGO:006034910.0FGFR2, FGFR3
13regulation of fat cell differentiationGO:00455989.9ALMS1, LEP
14insulin receptor signaling pathwayGO:00082869.9IGF1R, INS, INSR
15negative regulation of gluconeogenesisGO:00457219.9ADIPOQ, INS
16positive regulation of cellular protein metabolic processGO:00322709.8ADIPOQ, INS
17peptidyl-tyrosine phosphorylationGO:00181089.8FGFR2, FGFR3, INSR
18response to tumor necrosis factorGO:00346129.8ADIPOQ, INSR
19positive regulation of JAK-STAT cascadeGO:00464279.8LEP, PRL
20phosphatidylinositol-mediated signalingGO:00480159.8FGFR2, FGFR3, IGF1R
21cell-cell signalingGO:00072679.7FGFR2, FGFR3, INS
22MAPK cascadeGO:00001659.7FGFR2, FGFR3, INS
23positive regulation of protein kinase B signalingGO:00518979.7INS, INSR, LEP
24positive regulation of mitotic nuclear divisionGO:00458409.7INS, INSR
25positive regulation of DNA replicationGO:00457409.6IGF1R, INS, INSR
26fatty acid beta-oxidationGO:00066359.6ADIPOQ, LEP
27positive regulation of glucose importGO:00463269.5ADIPOQ, INS, INSR
28regulation of multicellular organism growthGO:00400149.4FGFR2, PRL
29positive regulation of cell migrationGO:00303359.4IGF1R, INS, INSR
30protein autophosphorylationGO:00467779.3FGFR2, FGFR3, IGF1R, INSR
31glucose metabolic processGO:00060069.2ADIPOQ, INS, LEP
32response to activityGO:00148238.9ADIPOQ, INSR, LEP
33positive regulation of MAPK cascadeGO:00434108.8FGFR2, FGFR3, INS, INSR, LEP
34response to ethanolGO:00454718.8ADIPOQ, INSR, LEP
35glucose homeostasisGO:00425938.4ADIPOQ, ALMS1, INS, INSR, LEP
36positive regulation of cell proliferationGO:00082847.7FGFR2, FGFR3, IGF1R, INS, INSR, LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.3FGFR2, FGFR3
2insulin-like growth factor receptor bindingGO:000515910.2INS, INSR
31-phosphatidylinositol-3-kinase activityGO:001630310.2FGFR2, FGFR3
4insulin-like growth factor I bindingGO:003199410.2IGF1R, INSR
5insulin receptor substrate bindingGO:004356010.1IGF1R, INSR
6insulin bindingGO:004355910.0IGF1R, INSR
7fibroblast growth factor bindingGO:001713410.0FGFR2, FGFR3
8phosphatidylinositol 3-kinase bindingGO:00435489.8IGF1R, INSR
9insulin receptor bindingGO:00051589.6IGF1R, INS
10protein tyrosine kinase activityGO:00047139.1FGFR2, FGFR3, IGF1R, INSR
11hormone activityGO:00051798.4ADIPOQ, INS, LEP, PRL

Sources for Acanthosis Nigricans

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet