MCID: ACN002
MIFTS: 57

Acanthosis Nigricans malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acanthosis Nigricans

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Aliases & Descriptions for Acanthosis Nigricans:

Name: Acanthosis Nigricans 10 45 47 12 36 65
an - Acanthosis Nigricans 10
 
Keratosis Nigricans 10
an 45

Characteristics:



Classifications:



External Ids:

Disease Ontology10 DOID:3138
ICD1027 L83
SNOMED-CT59 402599005, 72129000
MeSH36 D000052
NCIt42 C26687
UMLS65 C0000889

Summaries for Acanthosis Nigricans

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NIH Rare Diseases:45 Acanthosis nigricans (an) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. the exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. last updated: 8/18/2014

MalaCards based summary: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and beare-stevenson cutis gyrata syndrome, and has symptoms including hyperkeratosis, hypohidrosis and hypertrichosis. An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and Transcription_Transcription factor Tubby signaling pathways. Affiliated tissues include skin, bone and lung, and related mouse phenotypes are tumorigenesis and respiratory system.

Wikipedia:68 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Related Diseases for Acanthosis Nigricans

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Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome with acanthosis nigricans34.6FGFR2, FGFR3
2beare-stevenson cutis gyrata syndrome33.0FGFR2, FGFR3
3alstrom syndrome30.3ALMS1, LEP
4lipodystrophy, familial partial, 230.2LEP, LMNA
5hypogonadism30.1PRL, SHBG
6adrenal carcinoma29.1LEP, PRL
7obesity28.6ADIPOQ, ALMS1, INS, INSR, LEP, PRL
8diabetes mellitus, insulin-resistant, with acanthosis nigricans12.4
9insulin-resistant acanthosis nigricans, type a12.3
10acanthosis nigricans muscle cramps acral enlargement12.2
11diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension12.2
12saddan12.1
13cutis gyratum acanthosis nigricans craniosynostosis12.1
14leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome12.1
15acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome12.1
16hair-an syndrome11.8
17lelis syndrome11.8
18retinitis pigmentosa, deafness, mental retardation, and hypogonadism11.1
19adenocarcinoma10.6
20glomerulosclerosis, focal segmental, 110.6INS, INSR
21plagiocephaly and x-linked mental retardation10.6FGFR2, FGFR3
22hyperandrogenism10.6
23flna-related periventricular nodular heterotopia10.6FGFR2, FGFR3
24bladder cancer, somatic10.6FGFR2, FGFR3
25hypogonadotropic hypogonadism 2 with or without anosmia10.5FGFR2, FGFR3
26cyclotropia10.5FGFR2, FGFR3
27apert syndrome10.5FGFR2, FGFR3
28poland syndrome10.5FGFR2, FGFR3
29diverticulitis of colon10.5FGFR2, FGFR3
30crouzon syndrome10.5
31thanatophoric dysplasia, type i10.5FGFR2, FGFR3
32antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.5FGFR2, FGFR3
33fetal methimazole syndrome10.4INS, LEP
34polycystic ovary syndrome10.4
35gastric adenocarcinoma10.4
36maturity-onset diabetes of the young, type 1010.4INS, SHBG
37achondroplasia10.3
38slc16a1-related hyperinsulinism10.3FGFR2, FGFR3
39acquired hemophilia10.3ADIPOQ, LEP
40headache10.3INS, PRL
41mycosis fungoides10.3
42sella turcica neoplasm10.3INS, PRL
43lethal infantile mitochondrial myopathy10.3ADIPOQ, LEP
44graphite pneumoconiosis10.3INS, PRL
45arteriovenous malformation10.3INS, PRL
46acanthosis nigricans10.3ADIPOQ, LEP
47pulmonary embolism10.3INS, PRL
48idiopathic hypersomnia10.3ADIPOQ, INS
49lung cancer10.3
50hypochondroplasia10.3

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Symptoms for Acanthosis Nigricans

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HPO human phenotypes related to Acanthosis Nigricans:

(show all 8)
id Description Frequency HPO Source Accession
1 hyperkeratosis hallmark (90%) HP:0000962
2 hypohidrosis typical (50%) HP:0000966
3 hypertrichosis typical (50%) HP:0000998
4 obesity typical (50%) HP:0001513
5 generalized hyperpigmentation typical (50%) HP:0007440
6 type ii diabetes mellitus occasional (7.5%) HP:0005978
7 cognitive impairment occasional (7.5%) HP:0100543
8 acanthosis nigricans HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

Drugs & Therapeutics for Acanthosis Nigricans

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Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminapprovedPhase 4, Phase 3, Phase 21645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2Hypoglycemic AgentsPhase 4, Phase 3, Phase 24503
3Insulin, Globin ZincPhase 3, Phase 24278
4AutoantibodiesPhase 3117
5insulinPhase 3, Phase 24278
6
Leuprolideapproved, investigationalPhase 227953714-56-03911, 657181
Synonyms:
(D-Leu(6),des-gly-NH2(10),pro-ethylamide(9))-gonadotropin-releasing hormone
5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
AC1L1GZK
AC1L9B44
AC1Q5OPO
AR-1G9354
C07612
CID3911
CID441410
D00989
D08113
Eligard
Enantone
Enantone (TN)
I04-0109
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
L001094
 
L002030
Leuprolide
Leuprolide Acetate
Leuprolide acetate
Leuprolide acetate (USAN)
Leuprorelin
Leuprorelin (INN)
Leuprorelin acetate (JAN)
Leuprorelina
Leuproreline
Leuprorelinum
Lupron
Lupron (TN)
N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
NSC377526
NSC746847
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-NHC2H5
PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-nhet
acetic acid
leuprolide
7
SpironolactoneapprovedPhase 21591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
8Antineoplastic Agents, HormonalPhase 24256
9Natriuretic AgentsPhase 21403
10Diuretics, Potassium SparingPhase 21445
11EnclomiphenePhase 2158
12ZuclomiphenePhase 2158
13MineralocorticoidsPhase 2301
14ClomiphenePhase 2158
15HormonesPhase 211748
16Mineralocorticoid Receptor AntagonistsPhase 2284
17Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
18Hormone AntagonistsPhase 210002
19diureticsPhase 21194
20CitrateNutraceuticalPhase 21001
21
Citric AcidnutraceuticalPhase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
22
Melatoninapproved, nutraceutical23473-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
23
Pyridoxalapproved, nutraceutical16365-22-5, 66-72-81050
Synonyms:
3-HYDROXY-5-(hydroxymethyl)-2-methylisonicotinaldehyde
 
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
Pyridoxal
Pyridoxaldehyde
24
Pyridoxineapproved, nutraceutical16565-23-61054
Synonyms:
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
12001-78-4
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3-Hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
3-Hydroxy-4,5-dimethylol-alpha-picoline
3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol
4-Deoxypyridoxine 5'-phosphate
47862_SUPELCO
5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
58-56-0
58-56-0 (HCL)
58-56-0 (hydrochloride)
65-23-6
65-23-6 (Parent)
8059-24-3
85078-23-5
AC-12024
AC-14512
AC-907/25014218
AC1L1AMH
AC1L1LMI
AC1L2XK2
AC1Q22HP
AC1Q2G66
AC1Q3F63
AI3-19016
AIDS-006784
AIDS006784
AR-1A6363
AR-1J1632
Adermin hydrochloride
Adermine
Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Alestrol
BB_NC-0050
BIDD:PXR0180
BPBio1_000646
BSPBio_000586
Becilan
Beesix
Benadon
Bonasanit
C00314
C8H11NO3
CAS-58-56-0
CBDivE_015627
CCRIS 1903
CHEBI:16709
CHEBI:30961
CHEMBL1200756
CHEMBL1364
CID104817
CID1054
CID6019
CPD0-1221
Campoviton 6
Cernevit-12
D02179
D025101
D08454
DB00165
EINECS 200-386-2
EINECS 200-603-0
EINECS 232-503-8
Godabion
Gravidox
HMS1569N08
HMS2093L07
HSDB 1212
Hexa-Betalin
Hexa-Betalin (R)
Hexa-betalin (TN)
Hexabetalin
Hexabione hydrochloride
Hexavibex
 
Hexermin
Hexermine
Hexobion
Hydoxin
I02-1897
I02-2297
KST-1A8556
LS-134393
LS-187072
LS-2332
MLS001074329
MLS002153915
MolPort-002-137-856
MolPort-002-319-991
MolPort-005-933-330
NCGC00016261-01
NCGC00164317-01
NCGC00180946-01
NSC 36225
NSC36225
NSC36225 (HCL)
Nestrex
Oprea1_061614
P0561
P4722_SIAL
P5669_SIGMA
P6280_SIGMA
P8666_SIGMA
P9755_SIAL
PN
PN HCl
PYRIDOXINE HYDROCHLORIDE
PYRIDOXINE HYDROCHLORIDE, U.S.P.
Paxadon
Piridossina
Piridossina [DCIT]
Piridoxina
Piridoxina [INN-Spanish]
Prestwick0_000623
Prestwick1_000623
Prestwick2_000623
Prestwick3_000623
Prestwick_925
Pydox
Pyridipca
Pyridox
Pyridoxin
Pyridoxin hydrochloride
Pyridoxine
Pyridoxine (INN)
Pyridoxine HCl
Pyridoxine Hydrochloride
Pyridoxine Hydrochloride (B6)
Pyridoxine [INN:BAN]
Pyridoxine chloride
Pyridoxine hydrochloride
Pyridoxine hydrochloride (JP15/USP)
Pyridoxine hydrochloride [USAN:JAN]
Pyridoxine hydrogen chloride
Pyridoxine monohydrochloride
Pyridoxine, hydrochloride
Pyridoxine-HCl Microencapsulated
Pyridoxinium chloride
Pyridoxinum
Pyridoxinum [INN-Latin]
Pyridoxinum hydrochloricum
Pyridoxinum hydrochloricum (Hungarian)
Pyridoxol
Pyridoxol hydrochloride
Pyridoxol, hydrochloride
Pyridoxolum
Rodex
Rodex (R)
Rodex TD
SMP2_000230
SMR000674613
SPBio_002805
STK177324
STOCK1N-08684
Spondylonal
Tex Six T.R.
TimTec1_000657
UNII-68Y4CF58BV
UNII-KV2JZ1BI6Z
Vitamin B 6
Vitamin B6
Vitamin B6-hydrochloride
Vitamin V6
Vitamin V6 (TN)
Vitamin-?B6
Vitamin-?B6 hydrochloride
Vitaped
WLN: T6NJ B1 CQ D1Q E1Q &GH
ZINC00049154
ZINC21983293
bmse000288
c1302
component of Alestrol
nchembio.93-comp1
pyridoxine
vitamin B6
25Vitamin B 6165
26Vitamin B Complex2847
27Vitamins3857
28Calcium, Dietary4678
29Antioxidants2442
30Central Nervous System Depressants10016
31Protective Agents5651

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With ObesityNot yet recruitingNCT02438020Phase 4
2Adjunctive Metformin Therapy in Double DiabetesCompletedNCT01334125Phase 3
3Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans SyndromeCompletedNCT00004311Phase 2
4Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome PatientsCompletedNCT02562664Phase 2
5Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With HyperinsulinemiaCompletedNCT01125150
6Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid MetabolismCompletedNCT02604095
7Prevalence of Carbohydrate Intolerance in Lean and Obese ChildrenRecruitingNCT00000112

Search NIH Clinical Center for Acanthosis Nigricans


Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

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Anatomical Context for Acanthosis Nigricans

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MalaCards organs/tissues related to Acanthosis Nigricans:

33
Skin, Bone, Lung, Liver, Thyroid, Prostate, Ovary

Animal Models for Acanthosis Nigricans or affiliated genes

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MGI Mouse Phenotypes related to Acanthosis Nigricans:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9ADIPOQ, FGFR2, FGFR3, LEP, PRL
2MP:00053888.5ADIPOQ, FGFR2, FGFR3, INSR, LEP, LMNA
3MP:00053818.5FGFR2, FGFR3, INS, INSR, LEP, LMNA
4MP:00053698.2ADIPOQ, FGFR2, INS, INSR, LEP, LMNA
5MP:00053908.1ADIPOQ, FGFR2, FGFR3, INS, LEP, LMNA
6MP:00053918.1ALMS1, FGFR2, FGFR3, INS, LEP, LMNA
7MP:00036318.0FGFR2, FGFR3, INS, INSR, LEP, LMNA
8MP:00107718.0ADIPOQ, FGFR2, FGFR3, INS, LEP, LMNA
9MP:00053757.5ADIPOQ, ALMS1, FGFR2, INS, INSR, LEP
10MP:00053977.4ADIPOQ, FGFR2, FGFR3, INS, INSR, LEP
11MP:00053897.2ALMS1, FGFR2, FGFR3, INS, INSR, LEP
12MP:00053677.2ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
13MP:00053847.2ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
14MP:00053797.2ADIPOQ, ALMS1, FGFR2, INS, INSR, LEP
15MP:00053707.2ADIPOQ, ALMS1, FGFR2, INS, INSR, LEP
16MP:00053787.0ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
17MP:00053866.7ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
18MP:00053766.6ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR
19MP:00053876.3ADIPOQ, ALMS1, FGFR2, FGFR3, INS, INSR

Publications for Acanthosis Nigricans

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Articles related to Acanthosis Nigricans:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Unusual Presentation of Acanthosis Nigricans Associated With Metabolic Syndrome. (26861532)
2015
2
Acanthosis nigricans in type 2 diabetes: prevalence, correlates and potential as a simple clinical screening tool - a cross-sectional study in the Caribbean. (25031628)
2014
3
An approach to acanthosis nigricans. (25165638)
2014
4
Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease. (25506563)
2014
5
Paraneoplastic acanthosis nigricans maligna. (24353797)
2013
6
Generalised Acanthosis Nigricans in Childhood with Short Stature Associated with Poor Response to Growth Hormone Provocation. (24285118)
2013
7
Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review. (22179051)
2012
8
Atypical presentation of acanthosis nigricans. (23226673)
2012
9
Prevalence of Acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome. (21276250)
2011
10
Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach. (21698027)
2011
11
Malignant acanthosis nigricans in rectal adenocarcinoma. (21980718)
2011
12
Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids. (20865850)
2010
13
This is linear verrucous epidermal nevus, not acanthosis nigricans. (20036800)
2010
14
The involvement of insulin receptor genotypes in pre- and co-obese acanthosis Nigricans children and adolescent. (20857837)
2010
15
Significance of acanthosis nigricans in childhood obesity. (18476925)
2008
16
Acanthosis nigricans: a practical approach to evaluation and management. (19061584)
2008
17
Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate. (17939948)
2007
18
Acanthosis nigricans as an adverse effect of highly active antiretroviral therapy in an adolescent girl with human immunodeficiency virus infection. (16094236)
2005
19
Eyelid involvement in acanthosis nigricans: the importance of systemic screening. (16234716)
2005
20
Prevalence of acanthosis nigricans in newly-diagnosed type 2 diabetes. (15256325)
2004
21
Acanthosis nigricans in a boy with achondroplasia due to the classical Gly380Arg mutation in FGFR3. (15517832)
2004
22
Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome). (15456556)
2004
23
Acanthosis nigricans is a reliable cutaneous marker of insulin resistance in obese Japanese children. (14651545)
2003
24
Association of acanthosis nigricans with race and metabolic disturbances in obese women. (11743615)
2002
25
The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. (10696568)
2000
26
Acanthosis nigricans. (10212845)
1998
27
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
28
Malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma--a case report and review of literature. (9190991)
1997
29
Insulin receptor defects in the erythrocytes of obese Indian women with Acanthosis Nigricans. (9352137)
1997
30
Crouzon disease with acanthosis nigricans and melanocytic nevi. (8919518)
1996
31
Childhood acanthosis nigricans. (7648884)
1995
32
Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. (7493034)
1995
33
Acanthosis nigricans. (8021347)
1994
34
Case report: defective beta and alpha cell regulation in patients with hyperinsulinemia and acanthosis nigricans. (8172227)
1994
35
Malignant acanthosis nigricans associated with a renal tumor. (8125695)
1993
36
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990
37
Medical therapy for the syndrome of familial virilization, insulin resistance, and acanthosis nigricans. (2137793)
1990
38
Epidermal nevus syndrome with hemimegalencephaly: a clinical report of a case with acanthosis nigricans-like nevi on the face and neck, hemimegalencephaly, and hemihypertrophy of the body. (2751068)
1989
39
Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology. (3177823)
1988
40
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1988. A 13-year-old girl with secondary amenorrhea, obesity, acanthosis nigricans, and hirsutism. (3367952)
1988
41
Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans. (2950000)
1987
42
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (3305551)
1987
43
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. (3900841)
1985
44
Insulin-resistant diabetes mellitus and insulin receptor antibodies: variable association with acanthosis nigricans. (7287512)
1980
45
Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans. (6989695)
1980
46
Steroid-induced acanthosis nigricans in dermatomyositis. (443833)
1979
47
Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect. (400728)
1978
48
Cutaneous manifestation of internal malignancies (I). Acanthosis nigricans. (659033)
1978
49
50

Variations for Acanthosis Nigricans

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Expression for genes affiliated with Acanthosis Nigricans

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Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

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Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.8FGFR2, FGFR3
29.7INS, INSR
39.7INS, INSR
49.7INS, INSR
59.7INS, INSR
69.5FGFR2, FGFR3, INSR
7
Show member pathways
9.5FGFR2, FGFR3, INSR
8
Show member pathways
9.3ADIPOQ, INS, INSR
9
Show member pathways
9.3ADIPOQ, INS, INSR
109.2ADIPOQ, INS, LEP
11
Show member pathways
9.1FGFR2, FGFR3, INS, INSR
12
Show member pathways
8.9ADIPOQ, INS, INSR, LEP
13
Show member pathways
8.9ADIPOQ, INS, INSR, LEP
14
Show member pathways
8.9ADIPOQ, INS, INSR, LEP
15
Show member pathways
8.9ADIPOQ, INS, INSR, LEP
168.8INS, INSR, LEP, PRL
178.7ADIPOQ, INS, LEP, LMNA
188.6FGFR2, FGFR3, INS, INSR, PRL
19
Show member pathways
8.2FGFR2, FGFR3, INS, INSR, LEP, PRL

GO Terms for genes affiliated with Acanthosis Nigricans

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Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:004582110.4INS, INSR
2positive regulation of phospholipase activityGO:001051810.4FGFR2, FGFR3
3fatty acid beta-oxidationGO:000663510.3ADIPOQ, LEP
4negative regulation of gluconeogenesisGO:004572110.2ADIPOQ, INS
5activation of protein kinase B activityGO:003214810.2INS, INSR
6positive regulation of cellular protein metabolic processGO:003227010.2ADIPOQ, INS
7positive regulation of JAK-STAT cascadeGO:004642710.1LEP, PRL
8bone morphogenesisGO:00603499.9FGFR2, FGFR3
9response to tumor necrosis factorGO:00346129.9ADIPOQ, INSR
10regulation of multicellular organism growthGO:00400149.9FGFR2, PRL
11bone mineralizationGO:00302829.8FGFR2, FGFR3
12protein autophosphorylationGO:00467779.8FGFR2, FGFR3, INSR
13response to nutrient levelsGO:00316679.8ADIPOQ, INSR, LEP
14response to activityGO:00148239.8INSR, LEP
15MAPK cascadeGO:00001659.6FGFR2, FGFR3, INS
16response to ethanolGO:00454719.5ADIPOQ, INSR, LEP
17insulin receptor signaling pathwayGO:00082869.3FGFR2, FGFR3, INS
18positive regulation of MAPK cascadeGO:00434109.1FGFR2, FGFR3, INS, INSR, LEP
19glucose metabolic processGO:00060068.9ADIPOQ, INS, LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.3FGFR2, FGFR3
2protein tyrosine kinase activityGO:00047139.5FGFR2, FGFR3, INSR

Sources for Acanthosis Nigricans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet