AN
MCID: ACN002
MIFTS: 73

Acanthosis Nigricans (AN) malady

Skin diseases category

Summaries for Acanthosis Nigricans

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Acanthosis nigricans is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. these symptoms are more common in people with cancer. the exact cause of this condition is not well understood; but it can be genetically inherited or related to medical problems such as obesity, some prescription drugs, and cancer. last updated: 7/25/2011

MalaCards: Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to obesity and breast cancer, and has symptoms including autosomal dominant inheritance, hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance and diffuse/generalised skin hyperpigmentation/melanoderma. An important gene associated with Acanthosis Nigricans is INSR (insulin receptor), and among its related pathways are IRS activation and Selected targets of GCR-alpha. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and lung, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Wikipedia:63 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Description from OMIM:46 200170,100600

Aliases & Classifications for Acanthosis Nigricans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
acanthosis nigricans:
Inheritance: Autosomal dominant; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acanthosis nigricans 8 42 10 44 48 46 60
an - acanthosis nigricans 8
keratosis nigricans 8
an 42


External Ids:

Disease Ontology8 DOID:3138
NCIt39 C26687
MeSH34 D000052
MESH via Orphanet35 D000052
SNOMED-CT56 72129000, 402599005
ICD10 via Orphanet26 L83
SNOMED-CT via Orphanet57 402599005
UMLS via Orphanet61 C0000889
ICD1025 L83

Related Diseases for Acanthosis Nigricans

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 5871)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.4MC1R, INS, INSR, LEP, LMNA, SLC2A3
2breast cancer31.2MC1R, CYP21A2, BAIAP2L1, IGF1, IGF1R, SHBG
3adenocarcinoma31.1IGF1R, CYP21A2, FGFR2, INSR, SLC2A4, TGFA
4hyperandrogenism31.1GH1, SHBG, IGF1R, IGF1, CYP21A2, INS
5arthritis31.1LEP, ADIPOQ
6crouzon syndrome31.0FGFR2, FGFR3
7adenoma31.0GH1, SHBG, IGF1R, IGF1, CYP21A2, INS
8prostate cancer31.0TGFA, FGFR2, IGF1, IGF1R
9diabetes mellitus31.0INSR, LEP, LMNA, SLC2A3, SLC2A4, ADIPOQ
10myocardial infarction30.9ADIPOQ, SHBG
11schizophrenia30.9INSR, INS
12alzheimer's disease30.9SHBG, FGFR3, INS, INSR, SLC2A3
13neuropathy30.9INS, LMNA
14rheumatoid arthritis30.9INSR, ADIPOQ
15polycystic ovary syndrome30.9INS, INSR, LEP, LMNA, SLC2A4, ADIPOQ
16colorectal cancer30.8IGF1R, IGF1, FGFR2, FGFR3, INSR
17achondroplasia30.8FGFR2, FGFR3
18ischemia30.8INSR, SLC2A4
19dementia30.8INSR
20multiple sclerosis30.8MC1R
21myeloma30.7FGFR3, IGF1, IGF1R
22atherosclerosis30.7SHBG, IGF1, INS, LEP, LMNA, ADIPOQ
23rhabdomyosarcoma30.7IGF1R
24cystic fibrosis30.7INS
25squamous cell carcinoma30.6IGF1R, MC1R, FGFR2, FGFR3, INSR, SLC2A3
26pancreatic cancer30.6TGFA, FGFR2, IGF1R
27myopathy30.6IGF1, INS, LMNA, SLC2A4
28colon cancer30.6TGFA, SLC2A3, IGF1, IGF1R
29infertility30.6LEP, INS, CYP21A2, SHBG
30multiple myeloma30.6FGFR3, IGF1
31coronary artery disease30.6INS, INSR, LMNA, ADIPOQ, ADRB3
32lung cancer30.6IGF1R, IGF1
33hypothyroidism30.6SHBG, LEP, ADIPOQ
34osteoporosis30.6GH1, SHBG, IGF1, CYP21A2, LEP
35astrocytoma30.6FGFR2, SLC2A3, TGFA
36eating disorder30.6LEP, INS
37psoriasis30.6TGFA
38retinoblastoma30.5LMNA, INSR, FGFR3, FGFR2
39osteosarcoma30.5IGF1R, IGF1
40alopecia30.5SHBG
41endometriosis30.5ADIPOQ
42leiomyoma30.5INSR
43hypochondroplasia30.5FGFR3, FGFR2
44acromegaly30.5GH1, IGF1
45amenorrhea30.5SHBG, IGF1, INS, LEP
46hypertension30.5IGF1, INS, INSR, LEP, ADRB3
47hypoglycemia30.5GH1, IGF1, INS, INSR, SLC2A3, SLC2A4
48cushing's syndrome30.5GH1, IGF1, CYP21A2, LEP, ADIPOQ
49pituitary adenoma30.5LEP, FGFR2, IGF1, GH1
50pheochromocytoma30.5INSR

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to acanthosis nigricans

Clinical Features for Acanthosis Nigricans

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

200170,100600

Clinical synopsis from OMIM:

100600

Symptoms:

48 (show all 8)
  • autosomal dominant inheritance
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • hirsutism/hypertrichosis/increased body hair
  • generalized obesity
  • insulin-independent/type 2 diabetes
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures

Drugs & Therapeutics for Acanthosis Nigricans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acanthosis Nigricans

Drug clinical trials:

Search ClinicalTrials for Acanthosis Nigricans

Search NIH Clinical Center for Acanthosis Nigricans

Search CenterWatch for Acanthosis Nigricans

Genetic Tests for Acanthosis Nigricans

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Anatomical Context for Acanthosis Nigricans

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32MalaCards
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MalaCards organs/tissues related to Acanthosis Nigricans:

32
Skin, Ovary, Lung, Liver, Thyroid, B cells, Kidney, Breast, Prostate, Cervix, Myeloid, Skeletal muscle, Heart, Lymph node, Bone, Bone marrow

Animal Models for Acanthosis Nigricans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acanthosis Nigricans:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.4FGFR2, SLC2A4
2MP:000537110.3AGPAT2, LMNA
3MP:00053889.7IGF1R, IGF1, FGFR2, FGFR3, INSR
4MP:00053779.6MC1R, FGFR3, LMNA
5MP:00020069.4IGF1R, IGF1, MC1R, FGFR2, FGFR3
6MP:00053909.4IGF1R, IGF1, FGFR2, FGFR3, LMNA, TGFA
7MP:00053899.3GH1, FGFR2, FGFR3, INSR, SLC2A3, TGFA
8MP:00053759.1TGFA, BSCL2, GH1, IGF1R, LMNA, SLC2A4
9MP:00107719.0BSCL2, AGPAT2, IGF1R, MC1R, FGFR2, INS
10MP:00053829.0TGFA, LMNA, FGFR3, FGFR2, MC1R, IGF1R
11MP:00053698.9IGF1R, IGF1, INS, INSR, LEP, LMNA
12MP:00053678.9BSCL2, AGPAT2, IGF1, FGFR2, FGFR3, INS
13MP:00053978.6BSCL2, AGPAT2, IGF1R, IGF1, FGFR2, FGFR3
14MP:00053708.6BSCL2, GH1, AGPAT2, IGF1R, FGFR2, INS
15MP:00053818.5BSCL2, AGPAT2, IGF1R, FGFR2, FGFR3, INS
16MP:00053858.5BSCL2, IGF1R, IGF1, FGFR2, INS, INSR
17MP:00053848.4MC1R, IGF1, IGF1R, BSCL2, FGFR2, FGFR3
18MP:00036318.3GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
19MP:00053878.1FGFR2, IGF1, IGF1R, AGPAT2, BSCL2, FGFR3
20MP:00053868.1FGFR2, MC1R, IGF1R, AGPAT2, BSCL2, FGFR3
21MP:00107688.0FGFR2, IGF1, IGF1R, AGPAT2, BSCL2, FGFR3
22MP:00053767.6FGFR2, IGF1, IGF1R, AGPAT2, GH1, BSCL2
23MP:00053787.1FGFR2, MC1R, IGF1, IGF1R, AGPAT2, GH1

Publications for Acanthosis Nigricans

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Sources:
50PubMed
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Articles related to Acanthosis Nigricans:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Coexistence of insulin-derived amyloidosis and an overlying acanthosis nigricans-like lesion at the site of insulin injection. (22924529)
2013
2
Medical image. Acanthosis nigricans maligna. (23824031)
2013
3
Acanthosis nigricans. (23906259)
2013
4
Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children. (23329755)
2012
5
Nevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal nevus): three cases]. (22401682)
2012
6
Quantitative skin color measurements in acanthosis nigricans patients: colorimetry and diffuse reflectance spectroscopy. (23017175)
2012
7
Crouzon syndrome associated with acanthosis nigricans: prenatal 2D and 3D ultrasound findings and postnatal 3D CT findings. (23986840)
2012
8
Case report: acanthosis nigricans resulting from repetitive same-site insulin injections. (23377528)
2012
9
A comparison of blood pressure, body mass index, and acanthosis nigricans in school-age children. (20335230)
2010
10
Prevalence of acanthosis nigricans and its correlates in a cross-section of Nigerians with type 2 diabetes mellitus. (19762579)
2009
11
Acanthosis nigricans. (19460927)
2009
12
A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. (19470471)
2009
13
Significance of acanthosis nigricans in childhood obesity. (18476925)
2008
14
Treatment options in insulin resistance obesity-related acanthosis nigricans. (18492785)
2008
15
Paraneoplastic acanthosis nigricans and silent meningioma producing transforming growth factor-alpha. (19049942)
2008
16
Familial acanthosis nigricans due to K650T FGFR3 mutation. (17875876)
2007
17
Acanthosis nigricans and diabetes risk factors: prevalence in young persons seen in southwestern US primary care practices. (17548847)
2007
18
Physical signs for the general dental practitioner. Acanthosis nigricans. (17432778)
2007
19
Atypical localization of acanthosis nigricans in an obese patient with increased leptin level: is there an association? (16843127)
2006
20
Prevalence of obesity, acanthosis nigricans and hyperinsulinemia in an adolescent clinic. (16161528)
2005
21
Hyperkeratosis of the nipple and areola as a sign of malignant acanthosis nigricans. (16197404)
2005
22
Malignant acanthosis nigricans with liver secondaries from an occult primary adenocarcinoma of gastrointestinal tract. (16394413)
2005
23
Acanthosis nigricans. (15595345)
2004
24
Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome). (12457412)
2002
25
Association of acanthosis nigricans with risk of diabetes mellitus, and hormonal disturbances in arabian females: case-control study. (11684373)
2001
26
Pregnancy after treatment with the insulin-sensitizing agent troglitazone in an obese woman with the hyperandrogenic, insulin-resistant acanthosis nigricans syndrome. (10231062)
1999
27
Crouzon disease with acanthosis nigricans and melanocytic nevi. (8919518)
1996
28
Acromegaly-like features in a patient with severe Acanthosis nigricans and insulin resistance. (17429269)
1996
29
Malignant acanthosis nigricans in adrenal carcinoma. (8635841)
1995
30
Acanthosis nigricans caused by nicotinic acid: case report and review of the literature. (8075456)
1994
31
The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response. (8137990)
1994
32
Amenorrhea, insulin resistance and acanthosis nigricans. A hyperandrogenic and a normoandrogenic clinical forms]. (8303114)
1993
33
Acanthosis nigricans with oral lesions and a malignant visceral tumor: a case report. (1732492)
1992
34
Acanthosis nigricans and a rectal carcinoid. (1894773)
1991
35
Acanthosis nigricans. (1931564)
1991
36
Transient acanthosis nigricans following bone marrow transplantation for lymphoid malignancy. (2337739)
1990
37
Autophosphorylation of cultured skin fibroblast insulin receptors from patients with severe insulin resistance and acanthosis nigricans. (2645188)
1989
38
Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology. (3177823)
1988
39
Familial insulin-resistant diabetes mellitus without acanthosis nigricans or androgenization. (3144912)
1988
40
Hyperandrogenism, insulin resistance, acanthosis nigricans, and systemic lupus erythematosis associated with insulin receptor antibodies. (3386533)
1988
41
Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans. (2950000)
1987
42
Treatment of acanthosis nigricans with etretinate (Tigason) in a patient with Lawrence-Seip syndrome (generalized lipodystrophy). (2424246)
1986
43
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. (3900841)
1985
44
Insulin resistance, acanthosis nigricans, and polycystic ovaries associated with a circulating inhibitor of postbinding insulin action. (3884647)
1985
45
Metabolic importance of acanthosis nigricans. (3977332)
1985
46
Niacinamide and acanthosis nigricans. (6237615)
1984
47
Acanthosis nigricans combined with endocrinopathy--2 case reports. (6593428)
1984
48
Glycosaminoglycan deposition in the acanthosis nigricans lesions of the polycystic ovary syndrome. (6344826)
1983
49
Acanthosis nigricans, hirsutism, insulin resistance and insulin receptor defect. (6749340)
1982
50
Treatment of acanthosis nigricans with oral isotretinoin. (7352756)
1980

Genetic Variations for Acanthosis Nigricans

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Expression for genes affiliated with Acanthosis Nigricans

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acanthosis Nigricans

Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for genes affiliated with Acanthosis Nigricans

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2INSR, INS
210.0LEP, INSR, INS
310.0INS, INSR, LEP
4
Hide members
10.0INSR, INS, IGF1R
510.0IGF1, INS, INSR
69.9SLC2A4, INSR, INS
7
Hide members
9.9ADIPOQ, SLC2A4, INSR
89.9SLC2A3, SLC2A4
9
Apoptosis and survival Caspase cascade
Hide members
9.9LMNA, IGF1, IGF1R
109.9ADIPOQ, SLC2A4, LEP
119.9ADIPOQ, SLC2A4, LEP
129.8FGFR2, FGFR3, TGFA
139.8INSR, FGFR3, FGFR2, IGF1R
14
Hide members
9.8INSR, FGFR3, FGFR2, IGF1R
159.8IGF1R, FGFR2, FGFR3, INSR
169.8SLC2A4, LEP, INSR, INS
179.8IGF1R, IGF1, INS, INSR
18
Hide members
9.8IGF1R, IGF1, INS, INSR
199.8IGF1R, IGF1, INS, INSR
20
Hide members
9.8INS, INSR, SLC2A4, ADIPOQ
219.7ADIPOQ, SLC2A4, LEP, INSR
229.7IGF1R, FGFR2, FGFR3, ADRB3
23
Hide members
9.7SLC2A4, SLC2A3, LMNA
24
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.7ADRB3, INSR, IGF1, IGF1R
259.6IGF1R, FGFR2, FGFR3, TGFA
269.6FGFR3, IGF1, IGF1R, GH1
27
Hide members
9.6IGF1R, IGF1, FGFR2, FGFR3, INSR
28
Hide members
9.6IGF1R, FGFR2, FGFR3, INSR, SLC2A4
299.5IGF1R, INS, INSR, SLC2A4, ADIPOQ
309.5IGF1R, FGFR2, FGFR3, INSR, TGFA
31
Hide members
9.4IGF1R, IGF1, FGFR2, FGFR3, INS, INSR
32
Hide members
9.4IGF1R, IGF1, FGFR2, FGFR3, INSR, SLC2A4
33
Hide members
9.3GH1, IGF1, FGFR2, FGFR3, TGFA
34
Hide members
9.3GH1, IGF1R, FGFR2, FGFR3, INSR, ADRB3
35
Hide members
9.3IGF1R, IGF1, FGFR2, FGFR3, INS, TGFA
36
Translation Insulin regulation of translation
Hide members
9.2GH1, IGF1R, IGF1, INS, INSR, SLC2A4
37
Hide members
9.2GH1, IGF1R, FGFR2, FGFR3, INSR, TGFA
389.2GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
39
Hide members
9.1GH1, IGF1R, IGF1, FGFR2, FGFR3, TGFA
40
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
41
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
42
Hide members
9.0GH1, IGF1R, IGF1, FGFR2, FGFR3, INSR
43
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
44
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
45
Hide members
8.8GH1, IGF1R, IGF1, FGFR2, FGFR3, INS
46
Hide members
8.8SLC2A4, INSR, FGFR3, FGFR2, IGF1, IGF1R
47
Hide members
8.7GH1, IGF1R, IGF1, MC1R, FGFR2, FGFR3
48
Hide members
8.6GH1, TGFA, SLC2A4, SLC2A3, FGFR3, FGFR2
498.5ADIPOQ, BSCL2, GH1, AGPAT2, IGF1, INS

Compounds for genes affiliated with Acanthosis Nigricans

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6ADRB3
2cycloheximide4410.3SLC2A3
3dehydroepiandrosterone sulfate4410.3GH1, SHBG, CYP21A2
4gnrh4410.2CYP21A2, SHBG, GH1
5mecasermin44 1111.0INS, INSR, IGF1R, IGF1
6norepinephrine44 11 2411.9SLC2A4, ADRB3, CYP21A2, TGFA
7rosiglitazone44 49 28 11 2413.8LEP, INSR, INS, SLC2A4, SHBG, LMNA
8acipimox44 2810.8GH1, ADIPOQ, INS, IGF1, LEP
9cortisone44 2410.8IGF1, LEP, INS, GH1, CYP21A2
10oxandrolone44 1110.8INS, SHBG, GH1, IGF1
11aicar44 11 2411.7INSR, LEP, INS, SLC2A4, ADIPOQ, IGF1
12pioglitazone44 49 28 1112.7INS, SLC2A4, LEP, ADIPOQ, SHBG, INSR
13tamoxifen44 49 28 1112.6TGFA, FGFR2, SLC2A4, IGF1R, IGF1
14glibenclamide44 28 49 5912.6ADIPOQ, SLC2A4, LEP, INSR, INS, BAIAP2L1
15octreotide44 59 28 1112.6INSR, INS, IGF1R, GH1, ADIPOQ, IGF1
16clomiphene citrate449.6INSR, INS, CYP21A2, IGF1, IGF1R, SHBG
17dhea449.5SHBG, INS, GH1, CYP21A2, LEP, ADIPOQ
18glucose449.5CYP21A2, BAIAP2L1, IGF1, IGF1R, SLC2A4, INSR
19androstenedione44 2410.5IGF1, ADIPOQ, INS, CYP21A2, GH1, LEP
20acth449.5GH1, MC1R, IGF1, CYP21A2, LEP
21serine449.5LEP, LMNA, GH1, MC1R, FGFR3, ADIPOQ
2211beta-hydroxysteroid449.4ADIPOQ, SLC2A4, LEP, GH1, CYP21A2
23ly294002449.4LEP, INSR, IGF1R, ADIPOQ, TGFA, SLC2A4
24thyroxine44 2410.4INS, INSR, ADIPOQ, CYP21A2, SHBG, GH1
25ibmx44 28 5911.3IGF1, SLC2A4, INSR, INS, GH1, IGF1R
26glycerol44 11 2411.3GH1, SHBG, INS, INSR, LEP, SLC2A4
27hydrocortisone44 2 59 1112.2SHBG, INSR, ADIPOQ, INS, TGFA, IGF1
28progestin449.2INSR, IGF1, IGF1R, SHBG, ADIPOQ, TGFA
292-deoxyglucose44 1110.1SLC2A3, ADIPOQ, INSR, IGF1R, SLC2A4, IGF1
30dexamethasone44 49 28 1112.1SLC2A4, GH1, SHBG, ADRB3, ADIPOQ, INSR
31metformin44 49 1111.1INS, BAIAP2L1, IGF1, SHBG, INSR, LEP
32epinephrine44 11 2411.1TGFA, ADRB3, LEP, INSR, GH1, SHBG
33rapamycin449.0FGFR2, IGF1, IGF1R, INSR, INS, LEP
34dihydrotestosterone44 28 11 2412.0INSR, LEP, TGFA, ADIPOQ, GH1, SHBG
35wortmannin449.0LEP, INSR, INS, IGF1, SLC2A4, ADIPOQ
36h2o2449.0IGF1R, BAIAP2L1, MC1R, FGFR2, LEP, SLC2A4
37c-peptide449.0CYP21A2, INSR, LEP, ADIPOQ, IGF1R, SHBG
38pd 98,059449.0SLC2A4, IGF1, IGF1R, LEP, TGFA, GH1
39creatinine448.9SLC2A4, SHBG, IGF1, IGF1R, INS, ADIPOQ
40ribonucleic acid448.9FGFR2, SLC2A3, SLC2A4, GH1, IGF1R, IGF1
41vitamin d448.7TGFA, IGF1, MC1R, FGFR2, GH1, IGF1R
42genistein44 28 59 2 11 2413.7TGFA, SLC2A4, GH1, SHBG, IGF1R, IGF1
43phosphatidylinositol448.6INS, FGFR2, BAIAP2L1, INSR, IGF1, LEP
44glycogen44 249.6SLC2A3, INSR, INS, SLC2A4, IGF1R, ADIPOQ
45progesterone44 59 28 11 2412.6SLC2A4, TGFA, SLC2A3, LEP, FGFR2, CYP21A2
46testosterone44 59 11 2411.5ADIPOQ, INSR, INS, FGFR2, IGF1, SHBG
47alanine448.5TGFA, MC1R, GH1, SHBG, IGF1R, INS
48estradiol44 11 2410.5GH1, ADIPOQ, LEP, CYP21A2, TGFA, IGF1
49arginine448.1ADIPOQ, LMNA, ADRB3, TGFA, FGFR3, LEP
50lipid448.1LMNA, LEP, INSR, INS, SLC2A4, ADIPOQ

GO Terms for genes affiliated with Acanthosis Nigricans

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Sources:
16Gene Ontology
See all sources

Cellular components related to Acanthosis Nigricans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IGF1, INS, LEP, ADIPOQ, TGFA, GH1
2integral to plasma membraneGO:0058879.0IGF1R, MC1R, FGFR2, FGFR3, INSR, SLC2A4
3extracellular regionGO:0055769.0ADIPOQ, GH1, SHBG, IGF1, FGFR2, FGFR3
4plasma membraneGO:0058867.6IGF1R, IGF1, BAIAP2L1, MC1R, FGFR2, FGFR3

Biological processes related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:06026710.5INSR, INS
2positive regulation of developmental growthGO:04863910.5LEP, INSR
3bone mineralization involved in bone maturationGO:03563010.4LEP, IGF1
4bone maturationGO:07097710.4FGFR3, GH1
5positive regulation of phospholipase activityGO:01051810.4FGFR2, FGFR3
6positive regulation of protein kinase A signaling cascadeGO:01073910.4ADIPOQ, MC1R
7positive regulation of glycolysisGO:04582110.4INSR, INS, IGF1
8lung lobe morphogenesisGO:06046310.4IGF1, FGFR2
9positive regulation of glycogen biosynthetic processGO:04572510.3IGF1, INS, INSR
10positive regulation of insulin receptor signaling pathwayGO:04662810.3INS, LEP
11exocrine pancreas developmentGO:03101710.3INSR, IGF1, IGF1R
12negative regulation of mitosisGO:04583910.3FGFR2, FGFR3
13peptidyl-tyrosine phosphorylationGO:01810810.3INSR, FGFR3, FGFR2
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:06052710.3IGF1, FGFR2
15negative regulation of gluconeogenesisGO:04572110.2ADIPOQ, INS
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2GH1, FGFR3, LEP
17lens fiber cell developmentGO:07030710.2FGFR3, FGFR2
18positive regulation of glucose importGO:04632610.2IGF1, INS, INSR, ADIPOQ
19cellular response to insulin stimulusGO:03286910.2ADIPOQ, SLC2A4, INSR
20brown fat cell differentiationGO:05087310.2ADRB3, ADIPOQ, SLC2A4
21positive regulation of DNA replicationGO:04574010.2IGF1R, IGF1, INS, INSR
22protein autophosphorylationGO:04677710.1IGF1R, FGFR2, FGFR3, INSR
23positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1GH1, IGF1, INS
24glucose homeostasisGO:04259310.1ADIPOQ, SLC2A4, INSR, INS
25response to vitamin EGO:03319710.1IGF1R, LEP
26phosphatidylinositol-mediated signalingGO:04801510.1IGF1R, IGF1, FGFR2, FGFR3
27MAPK cascadeGO:00016510.1TGFA, INS, FGFR3
28positive regulation of epithelial cell proliferationGO:05067910.1IGF1, FGFR2, TGFA
29positive regulation of mitosisGO:04584010.1IGF1, INS, INSR, TGFA
30insulin receptor signaling pathwayGO:00828610.1IGF1R, FGFR2, FGFR3, INS, INSR
31male sex determinationGO:03023810.0IGF1R, INSR
32positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0ADIPOQ, INS, IGF1, GH1
33positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0IGF1, GH1
34positive regulation of protein kinase B signaling cascadeGO:05189710.0IGF1R, IGF1, MC1R, INS, INSR
35glucose transportGO:0157589.8GH1, INS, SLC2A3, SLC2A4
36positive regulation of cellular protein metabolic processGO:0322709.8ADIPOQ, INS
37positive regulation of cell proliferationGO:0082849.7IGF1R, IGF1, FGFR2, FGFR3, INS, INSR
38positive regulation of MAPK cascadeGO:0434109.4ADRB3, IGF1R, IGF1, FGFR2, FGFR3, INS

Molecular functions related to Acanthosis Nigricans according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin bindingGO:04355910.3IGF1R, INSR
2fibroblast growth factor-activated receptor activityGO:00500710.2FGFR2, FGFR3
3insulin-like growth factor receptor bindingGO:00515910.2IGF1, INS, INSR
4insulin receptor substrate bindingGO:04356010.1INSR, IGF1R
5insulin receptor bindingGO:00515810.1INS, IGF1, IGF1R
6insulin-like growth factor I bindingGO:03199410.0IGF1R, INSR
7protein tyrosine kinase activityGO:00471310.0IGF1R, FGFR2, FGFR3, INSR
8hormone activityGO:0051799.7ADIPOQ, LEP, INS, IGF1, GH1
9glucose transmembrane transporter activityGO:0053559.6SLC2A4, SLC2A3
10growth factor activityGO:0080839.6TGFA, LEP, IGF1, GH1
11protein bindingGO:0055157.8GH1, IGF1R, IGF1, MC1R, FGFR2, FGFR3

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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36MGI
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40NDF-RT
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