Aliases & Classifications for Acanthosis Nigricans

MalaCards integrated aliases for Acanthosis Nigricans:

Name: Acanthosis Nigricans 53 12 72 49 28 51 41 14 69
an - Acanthosis Nigricans 12
Keratosis Nigricans 12
an 49

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
acanthosis nigricans:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 100600
Disease Ontology 12 DOID:3138
ICD10 32 L83
MeSH 41 D000052
NCIt 46 C26687
SNOMED-CT 64 402599005 72129000
MedGen 39 C0000889
SNOMED-CT via HPO 65 263681008
UMLS 69 C0000889

Summaries for Acanthosis Nigricans

NIH Rare Diseases : 49 Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. This condition usually appears slowly and doesn't cause any symptoms other than skin changes. Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. Less commonly, the lips, palms, soles of the feet, or other areas may be affected. The exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. Last updated: 8/18/2014

MalaCards based summary : Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to beare-stevenson cutis gyrata syndrome and pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities, and has symptoms including pruritus An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are PEDF Induced Signaling and p70S6K Signaling. The drugs Metformin and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and lung, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 72 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Description from OMIM: 100600

Related Diseases for Acanthosis Nigricans

Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 beare-stevenson cutis gyrata syndrome 33.4 FGFR2 FGFR3
2 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 32.2 INS INSR
3 alstrom syndrome 31.7 ALMS1 INS LEP
4 lipodystrophy, familial partial, type 2 31.2 INS LEP LMNA
5 congenital generalized lipodystrophy 31.2 INS LEP LMNA
6 hyperandrogenism 30.9 INS INSR SHBG
7 hypochondroplasia 30.7 FGFR2 FGFR3
8 luteoma 30.3 FGFR2 FGFR3
9 thanatophoric dysplasia, type i 30.2 FGFR2 FGFR3
10 body mass index quantitative trait locus 11 30.2 ADIPOQ INS INSR LEP SHBG
11 polycystic ovary syndrome 30.1 INS INSR LEP SHBG
12 nonalcoholic steatohepatitis 29.7 ADIPOQ INS LEP
13 diabetes mellitus 29.7 ADIPOQ INS INSR LEP SHBG
14 morbid obesity 29.7 ADIPOQ INS LEP
15 hyperinsulinism 29.4 INS INSR LEP SHBG
16 gestational diabetes 29.0 ADIPOQ INS INSR LEP SHBG
17 lipodystrophy 29.0 ADIPOQ INS LEP LMNA
18 diabetes mellitus, noninsulin-dependent 27.2 ADIPOQ IGF1R INS INSR LEP LMNA
19 crouzon syndrome with acanthosis nigricans 12.7
20 achondroplasia, severe, with developmental delay and acanthosis nigricans 12.7
21 diabetes mellitus, insulin-resistant, with acanthosis nigricans 12.5
22 acanthosis nigricans with muscle cramps and acral enlargement 12.4
23 insulin-resistant acanthosis nigricans, type a 12.3
24 cutis gyratum acanthosis nigricans craniosynostosis 12.1
25 leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome 12.1
26 hair-an syndrome 12.1
27 lelis syndrome 12.1
28 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.2
29 papillomatosis, confluent and reticulated 11.1
30 lipodystrophy, congenital generalized, type 1 11.1
31 aromatase deficiency 11.1
32 insulin-resistance type b 11.1
33 retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome 11.1
34 body mass index quantitative trait locus 9 10.8
35 body mass index quantitative trait locus 8 10.8
36 body mass index quantitative trait locus 7 10.8
37 body mass index quantitative trait locus 12 10.8
38 body mass index quantitative trait locus 14 10.8
39 body mass index quantitative trait locus 18 10.8
40 body mass index quantitative trait locus 4 10.8
41 body mass index quantitative trait locus 10 10.8
42 adenocarcinoma 10.6
43 crouzon syndrome 10.5
44 insulin autoimmune syndrome 10.4 INS INSR
45 gastric adenocarcinoma 10.4
46 plagiocephaly 10.4 FGFR2 FGFR3
47 osteoglophonic dysplasia 10.3 FGFR2 FGFR3
48 achondroplasia 10.3
49 jackson-weiss syndrome 10.3 FGFR2 FGFR3
50 pigmentation disease 10.3 FGFR3 INS

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to Acanthosis Nigricans

Symptoms & Phenotypes for Acanthosis Nigricans

Symptoms via clinical synopsis from OMIM:

53
Skin:
benign acanthosis nigricans
thick hyperpigmented flexural area skin


Clinical features from OMIM:

100600

Human phenotypes related to Acanthosis Nigricans:

31
# Description HPO Frequency HPO Source Accession
1 acanthosis nigricans 31 HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

GenomeRNAi Phenotypes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 FGFR2 FGFR3 IGF1R INSR
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR2 FGFR3 INSR
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 INSR

MGI Mouse Phenotypes related to Acanthosis Nigricans:

43 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 INSR ALMS1 LMNA ADIPOQ FGFR2 LEP
2 cellular MP:0005384 10.25 INSR ALMS1 LMNA ADIPOQ FGFR2 LEP
3 growth/size/body region MP:0005378 10.23 ALMS1 INSR LMNA ADIPOQ FGFR2 LEP
4 adipose tissue MP:0005375 10.22 ALMS1 LMNA ADIPOQ FGFR2 LEP INSR
5 homeostasis/metabolism MP:0005376 10.2 FGFR2 LEP ALMS1 INSR LMNA ADIPOQ
6 endocrine/exocrine gland MP:0005379 10.19 INSR ALMS1 LMNA ADIPOQ FGFR2 LEP
7 immune system MP:0005387 10.19 INSR ALMS1 LMNA ADIPOQ FGFR2 LEP
8 hematopoietic system MP:0005397 10.16 FGFR2 LEP INSR LMNA ADIPOQ INS
9 cardiovascular system MP:0005385 10.15 LEP FGFR2 INSR ADIPOQ LMNA INS
10 digestive/alimentary MP:0005381 10.14 INSR LMNA FGFR2 LEP INS IGF1R
11 liver/biliary system MP:0005370 10.1 INSR ALMS1 LMNA ADIPOQ FGFR2 LEP
12 mortality/aging MP:0010768 10.08 ADIPOQ LEP FGFR2 INSR INS FGFR3
13 integument MP:0010771 10.07 LMNA ADIPOQ FGFR2 LEP INS IGF1R
14 nervous system MP:0003631 10.01 FGFR2 LEP ALMS1 INSR INS IGF1R
15 muscle MP:0005369 10 INSR LMNA ADIPOQ FGFR2 LEP INS
16 hearing/vestibular/ear MP:0005377 9.97 FGFR2 ALMS1 IGF1R FGFR3 LMNA
17 renal/urinary system MP:0005367 9.92 INSR ALMS1 FGFR3 LMNA ADIPOQ FGFR2
18 limbs/digits/tail MP:0005371 9.91 LEP FGFR2 LMNA IGF1R FGFR3
19 reproductive system MP:0005389 9.86 INSR ALMS1 LMNA FGFR2 LEP IGF1R
20 neoplasm MP:0002006 9.83 LEP FGFR2 ADIPOQ IGF1R FGFR3
21 respiratory system MP:0005388 9.7 INSR LMNA ADIPOQ FGFR2 LEP IGF1R
22 pigmentation MP:0001186 9.67 LEP FGFR2 ALMS1 LMNA
23 skeleton MP:0005390 9.5 FGFR2 LEP ADIPOQ INS IGF1R FGFR3
24 vision/eye MP:0005391 9.1 LEP FGFR2 ALMS1 LMNA INS FGFR3

Drugs & Therapeutics for Acanthosis Nigricans

Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 4091 14219
2 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Enclomiphene Investigational Phase 3,Phase 2 15690-57-0
5 Autoantibodies Phase 3
6 insulin Phase 3,Phase 2
7 Insulin, Globin Zinc Phase 3,Phase 2
8 Clomiphene Phase 3,Phase 2
9 Estrogen Antagonists Phase 3,Phase 2
10 Estrogen Receptor Modulators Phase 3,Phase 2
11 Estrogens Phase 3,Phase 2
12 Fertility Agents Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Selective Estrogen Receptor Modulators Phase 3,Phase 2
17 Zuclomiphene Phase 3,Phase 2
18 Aromatase Inhibitors Phase 3
19 Steroid Synthesis Inhibitors Phase 3
20
Leuprolide Approved, Investigational Phase 2 53714-56-0 657181 3911
21
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
22
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
23 Antineoplastic Agents, Hormonal Phase 2
24 diuretics Phase 2
25 Diuretics, Potassium Sparing Phase 2
26 Mineralocorticoid Receptor Antagonists Phase 2
27 Mineralocorticoids Phase 2
28 Natriuretic Agents Phase 2
29 Citrate Nutraceutical Phase 2
30
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
31
Pyridoxal Approved, Nutraceutical 66-72-8 1050
32
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved 65-23-6 1054
33 Antioxidants
34 Calcium, Dietary
35 Central Nervous System Depressants
36 Protective Agents
37 Vitamin B 6
38 Vitamin B Complex
39 Vitamins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
2 Adjunctive Metformin Therapy in Double Diabetes Completed NCT01334125 Phase 3 Metformin;Placebo
3 Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome Recruiting NCT03135301 Phase 3 letrozole plus metformin;letrozole
4 Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed NCT00004311 Phase 2 leuprolide acetate;spironolactone
5 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2 CC;Placebo tablets;Metformin
6 Prevalence of Carbohydrate Intolerance in Lean and Obese Children Unknown status NCT00000112
7 Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia Completed NCT01125150 Metformin
8 Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism Completed NCT02604095

Search NIH Clinical Center for Acanthosis Nigricans

Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

Genetic tests related to Acanthosis Nigricans:

# Genetic test Affiliating Genes
1 Acanthosis Nigricans 28

Anatomical Context for Acanthosis Nigricans

MalaCards organs/tissues related to Acanthosis Nigricans:

38
Skin, Ovary, Lung, Liver, Prostate, Thyroid, Testes

Publications for Acanthosis Nigricans

Articles related to Acanthosis Nigricans:

(show top 50) (show all 602)
# Title Authors Year
1
Familial acanthosis nigricans with p.K650T FGFR3 mutation. ( 29068064 )
2018
2
Acanthosis nigricans and the metabolic syndrome. ( 29241752 )
2018
3
Crouzon with Acanthosis Nigricans and Odontogenic Tumors: A Rare Form of Syndromic Craniosynostosis. ( 29351036 )
2018
4
The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices. ( 28367214 )
2017
5
Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children. ( 28892990 )
2017
6
Paediatric obesity treatment had better outcomes when children were younger, well motivated and did not have acanthosis nigricans. ( 28685930 )
2017
7
Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans. ( 29115953 )
2017
8
A study of the association of acanthosis nigricans with subclinical atherosclerosis. ( 28164885 )
2017
9
Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review. ( 28295566 )
2017
10
Association of metabolic syndrome with low birth weight, intake of high-calorie diets and acanthosis nigricans in children and adolescents with overweight and obesity. ( 28440765 )
2017
11
Mild achondroplasia/hypochondroplasia with acanthosis nigricans, normal development, and a p.Ser348Cys FGFR3 mutation. ( 28181399 )
2017
12
Image Gallery: Generalized mucosal and cutaneous papillomatosis, a unique sign of malignant acanthosis nigricans. ( 28504375 )
2017
13
Gastric Cancer Associated With Malignant Acanthosis Nigricans. ( 28317636 )
2017
14
Comment about the article: A<Association of metabolic syndrome with low birth weight, intake of high-calorie diets and acanthosis nigricans in children and adolescents with overweight and obesityA>. ( 29066311 )
2017
15
Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female. ( 28413386 )
2017
16
Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma. ( 29178944 )
2017
17
Effects of glycolic acid peeling on the cutaneous manifestation of generalized acanthosis nigricans caused by FGFR3 mutation: A report of one sporadic and two familial cases. ( 28620983 )
2017
18
Acanthosis Nigricans and Its Response to Metformin. ( 28758315 )
2017
19
Acanthosis Nigricans ( 28613711 )
2017
20
Reply to the comment to our article titled: A<Association of metabolic syndrome with low birth weight of birth, intake hypercaloric diets and acanthosis nigricans in childhood and teens with overweight and obesityA>. ( 29179858 )
2017
21
Successful Repigmentation of Vitiligo-Like Hypopigmentation in a Case of Acanthosis Nigricans. ( 28392666 )
2017
22
Arterial stiffening, insulin resistance and acanthosis nigricans in a community sample of adolescents with obesity. ( 28465605 )
2017
23
Acanthosis nigricans: A screening test for insulin resistance - An important risk factor for diabetes mellitus type-2. ( 29026747 )
2017
24
Terra Firma-Forme Dermatosis Misdiagnosed as Nevoid Acanthosis Nigricans. ( 28930108 )
2017
25
Facial Acanthosis Nigricans: A Morphological Marker of Metabolic Syndrome. ( 29263532 )
2017
26
A Mutation in INSR in a Child Presenting with Severe Acanthosis Nigricans. ( 28663160 )
2017
27
The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors. ( 28081576 )
2017
28
Acanthosis nigricans in a Japanese boy with hypochondroplasia due to a K650T mutation in<i>FGFR3</i>. ( 29026271 )
2017
29
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges. ( 28031729 )
2017
30
FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. ( 27190511 )
2016
31
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer. ( 27536145 )
2016
32
IMAGES IN CLINICAL MEDICINE. Acanthosis Nigricans and Insulin Resistance. ( 27305209 )
2016
33
Acanthosis Nigricans associated with clear-cell renal cell carcinoma. ( 27284539 )
2016
34
Bilaterally mammary acanthosis nigricans as paraneoplastic manifestation of prostate adenocarcinoma. ( 27595210 )
2016
35
Unilateral nevoid acanthosis nigricans treated with CO2 laser. ( 27457822 )
2016
36
Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans. ( 26860419 )
2016
37
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. ( 27167874 )
2016
38
Lelis Syndrome: A Rare Cause of Acanthosis Nigricans. ( 27595879 )
2016
39
Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: a case report. ( 27987313 )
2016
40
Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial. ( 27999648 )
2016
41
ACANTHOSIS NIGRICANS AND SEVERE INSULIN RESISTANCE IN A BOY WITH ATAXIA. ( 27124696 )
2016
42
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. ( 27746646 )
2016
43
Acanthosis nigricans in insulinoma: before and after successful surgical enucleation. ( 27836838 )
2016
44
Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR3 mutation. ( 26818779 )
2016
45
Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific. ( 27631218 )
2016
46
Linear acanthosis nigricans on the anterior neck: Koebner phenomenon observed in a patient with acanthosis nigricans. ( 27569660 )
2016
47
Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease. ( 27051830 )
2016
48
Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection. ( 27598021 )
2016
49
A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism. ( 27505086 )
2016
50
A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR. ( 27990384 )
2016

Variations for Acanthosis Nigricans

ClinVar genetic disease variations for Acanthosis Nigricans:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FGFR3 NM_000142.4(FGFR3): c.1948A> C (p.Lys650Gln) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
2 FGFR3 NM_000142.4(FGFR3): c.1943A> C (p.Tyr648Ser) single nucleotide variant Likely pathogenic rs587779383 GRCh38 Chromosome 4, 1806157: 1806157

Expression for Acanthosis Nigricans

Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for Acanthosis Nigricans

Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 FGFR2 FGFR3 IGF1R INS INSR LEP
2
Show member pathways
12.85 FGFR2 FGFR3 IGF1R INS INSR
3
Show member pathways
12.77 FGFR2 FGFR3 IGF1R INS INSR
4
Show member pathways
12.6 ADIPOQ INS INSR LEP
5
Show member pathways
12.55 FGFR2 FGFR3 INS INSR
6 12.54 FGFR2 FGFR3 IGF1R INS INSR
7
Show member pathways
12.5 FGFR2 FGFR3 IGF1R INS INSR
8 12.34 ADIPOQ IGF1R INS INSR
9
Show member pathways
12.25 FGFR2 FGFR3 IGF1R INSR
10 12.22 FGFR2 FGFR3 IGF1R
11
Show member pathways
12.04 INS INSR LEP
12
Show member pathways
12.02 FGFR2 FGFR3 IGF1R INS INSR
13 11.94 FGFR2 FGFR3 IGF1R
14
Show member pathways
11.93 IGF1R INS INSR
15
Show member pathways
11.91 ADIPOQ IGF1R INS INSR
16
Show member pathways
11.87 IGF1R INS INSR
17 11.87 FGFR2 FGFR3 IGF1R INSR
18
Show member pathways
11.84 FGFR2 FGFR3 IGF1R INSR LMNA
19 11.79 ADIPOQ INS LEP LMNA
20 11.77 IGF1R INS INSR
21
Show member pathways
11.77 ADIPOQ IGF1R INS INSR LEP
22 11.74 ADIPOQ INS LEP
23
Show member pathways
11.73 ADIPOQ INS INSR
24 11.39 IGF1R INS INSR
25 11.37 INS INSR LEP
26 11.22 INS INSR
27 11.22 FGFR2 FGFR3 IGF1R INSR
28 11.11 INS INSR
29 11.03 ADIPOQ LEP
30 10.84 FGFR2 FGFR3 IGF1R INSR
31 10.84 ADIPOQ INSR LEP
32 10.58 FGFR2 FGFR3 IGF1R INSR

GO Terms for Acanthosis Nigricans

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.94 FGFR2 FGFR3 IGF1R INSR
2 positive regulation of cell migration GO:0030335 9.81 IGF1R INS INSR
3 response to ethanol GO:0045471 9.77 ADIPOQ FGFR2 LEP
4 insulin receptor signaling pathway GO:0008286 9.73 IGF1R INS INSR
5 protein autophosphorylation GO:0046777 9.71 FGFR2 FGFR3 IGF1R INSR
6 glucose metabolic process GO:0006006 9.67 ADIPOQ INS LEP
7 peptidyl-tyrosine phosphorylation GO:0018108 9.67 FGFR2 FGFR3 IGF1R INSR
8 bone mineralization GO:0030282 9.65 FGFR2 FGFR3
9 activation of protein kinase B activity GO:0032148 9.65 INS INSR
10 bone morphogenesis GO:0060349 9.64 FGFR2 FGFR3
11 positive regulation of mitotic nuclear division GO:0045840 9.63 INS INSR
12 positive regulation of cell proliferation GO:0008284 9.63 FGFR2 FGFR3 IGF1R INS INSR LEP
13 positive regulation of glycolytic process GO:0045821 9.62 INS INSR
14 positive regulation of cellular protein metabolic process GO:0032270 9.62 ADIPOQ INS
15 positive regulation of glycogen biosynthetic process GO:0045725 9.61 INS INSR
16 negative regulation of gluconeogenesis GO:0045721 9.61 ADIPOQ INS
17 positive regulation of DNA replication GO:0045740 9.61 IGF1R INS INSR
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.6 INS LEP
19 amyloid-beta clearance GO:0097242 9.58 IGF1R INSR
20 dendritic spine maintenance GO:0097062 9.58 IGF1R INSR
21 positive regulation of phospholipase activity GO:0010518 9.57 FGFR2 FGFR3
22 glucose homeostasis GO:0042593 9.56 ADIPOQ INS INSR LEP
23 endochondral bone growth GO:0003416 9.55 FGFR2 FGFR3
24 regulation of protein localization to nucleus GO:1900180 9.54 LEP LMNA
25 positive regulation of respiratory burst GO:0060267 9.52 INS INSR
26 neuron projection maintenance GO:1990535 9.51 INS INSR
27 positive regulation of glucose import GO:0046326 9.5 ADIPOQ INS INSR
28 positive regulation of developmental growth GO:0048639 9.48 INSR LEP
29 positive regulation of protein complex disassembly GO:0043243 9.46 IGF1R INSR
30 positive regulation of protein kinase B signaling GO:0051897 9.35 FGFR2 FGFR3 INS INSR LEP
31 positive regulation of MAPK cascade GO:0043410 9.02 FGFR2 FGFR3 INS INSR LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.8 FGFR2 FGFR3 IGF1R INSR
2 insulin receptor binding GO:0005158 9.51 IGF1R INS
3 hormone activity GO:0005179 9.5 ADIPOQ INS LEP
4 fibroblast growth factor binding GO:0017134 9.48 FGFR2 FGFR3
5 phosphatidylinositol 3-kinase binding GO:0043548 9.46 IGF1R INSR
6 insulin-like growth factor receptor binding GO:0005159 9.43 INS INSR
7 insulin receptor substrate binding GO:0043560 9.4 IGF1R INSR
8 insulin-like growth factor I binding GO:0031994 9.37 IGF1R INSR
9 fibroblast growth factor-activated receptor activity GO:0005007 9.26 FGFR2 FGFR3
10 protein tyrosine kinase activity GO:0004713 9.26 FGFR2 FGFR3 IGF1R INSR
11 insulin binding GO:0043559 9.16 IGF1R INSR
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 FGFR2 FGFR3 IGF1R INSR

Sources for Acanthosis Nigricans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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