Aliases & Classifications for Acanthosis Nigricans

MalaCards integrated aliases for Acanthosis Nigricans:

Name: Acanthosis Nigricans 12 50 29 52 42 14 69
an - Acanthosis Nigricans 12
Keratosis Nigricans 12
an 50

Characteristics:

HPO:

32
acanthosis nigricans:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:3138
ICD10 33 L83
MeSH 42 D000052
NCIt 47 C26687
SNOMED-CT 64 402599005 72129000
UMLS 69 C0000889

Summaries for Acanthosis Nigricans

NIH Rare Diseases : 50 acanthosis nigricans (an) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. this condition usually appears slowly and doesn't cause any symptoms other than skin changes. eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. less commonly, the lips, palms, soles of the feet, or other areas may be affected. the exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer. last updated: 8/18/2014

MalaCards based summary : Acanthosis Nigricans, also known as an - acanthosis nigricans, is related to crouzon syndrome with acanthosis nigricans and alstrom syndrome, and has symptoms including pruritus An important gene associated with Acanthosis Nigricans is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are PEDF Induced Signaling and p70S6K Signaling. The drugs Metformin and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and lung, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 72 Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is... more...

Related Diseases for Acanthosis Nigricans

Diseases related to Acanthosis Nigricans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
id Related Disease Score Top Affiliating Genes
1 crouzon syndrome with acanthosis nigricans 34.5 FGFR2 FGFR3
2 alstrom syndrome 31.6 ALMS1 INS LEP
3 lipodystrophy, familial partial, type 2 31.0 INS LEP LMNA
4 hyperlipoproteinemia type iv 29.6 ADIPOQ INS LEP
5 diabetes mellitus, insulin-resistant, with acanthosis nigricans 12.4
6 insulin-resistant acanthosis nigricans, type a 12.2
7 saddan 12.2
8 acanthosis nigricans with muscle cramps and acral enlargement 12.1
9 diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension 12.1
10 cutis gyratum acanthosis nigricans craniosynostosis 12.0
11 leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome 12.0
12 hair-an syndrome 12.0
13 lelis syndrome 11.9
14 beare-stevenson cutis gyrata syndrome 11.8
15 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.0
16 lipodystrophy, congenital generalized, type 1 11.0
17 aromatase deficiency 11.0
18 rabson-mendenhall syndrome 11.0
19 insulin-resistance type b 11.0
20 obesity 10.7
21 intellectual deficit buenos-aires type 10.6 INS INSR
22 plasmalogens synthesis deficiency isolated 10.5 FGFR2 FGFR3
23 trigonocephaly 1 10.5 FGFR2 FGFR3
24 ocular hypotension 10.5 FGFR2 FGFR3
25 adenocarcinoma 10.5
26 apert syndrome 10.5 FGFR2 FGFR3
27 hyperandrogenism 10.5
28 hypogonadotropic hypogonadism 2 with or without anosmia 10.5 FGFR2 FGFR3
29 esotropia 10.4 FGFR2 FGFR3
30 acute hydrops keratoconus 10.4 FGFR3 INS
31 myh-9 related disease 10.4 INS LEP
32 crouzon syndrome 10.4
33 thanatophoric dysplasia, type i 10.3 FGFR2 FGFR3
34 maturity-onset diabetes of the young, type 10 10.3 INS SHBG
35 polycystic ovary syndrome 10.3
36 gastric adenocarcinoma 10.3
37 acquired hypoprothrombinemia 10.3 ADIPOQ LEP
38 achondroplasia 10.2
39 leigh syndrome with leukodystrophy 10.2 ADIPOQ LEP
40 conjunctival vascular disease 10.2 INS SHBG
41 idiopathic juxtafoveal retinal telangiectasia 10.2 ADIPOQ INS
42 fetal parvovirus syndrome 10.2 INS INSR LEP
43 scleredema adultorum 10.2 ADIPOQ LEP
44 lung cancer 10.2
45 hypochondroplasia 10.2
46 mycosis fungoides 10.2
47 not otherwise specified 3-mga-uria type 10.2 ADIPOQ LEP
48 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.2 FGFR2 FGFR3
49 hepatitis 10.1
50 squamous cell carcinoma 10.1

Graphical network of the top 20 diseases related to Acanthosis Nigricans:



Diseases related to Acanthosis Nigricans

Symptoms & Phenotypes for Acanthosis Nigricans

Human phenotypes related to Acanthosis Nigricans:

32
id Description HPO Frequency HPO Source Accession
1 acanthosis nigricans 32 HP:0000956

UMLS symptoms related to Acanthosis Nigricans:


pruritus

GenomeRNAi Phenotypes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 FGFR2 FGFR3 IGF1R INSR
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 INSR FGFR2
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 INSR

MGI Mouse Phenotypes related to Acanthosis Nigricans:

44 (show all 23)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 FGFR3 IGF1R INS INSR LEP LMNA
2 cellular MP:0005384 10.24 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
3 growth/size/body region MP:0005378 10.22 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
4 adipose tissue MP:0005375 10.21 LEP LMNA ADIPOQ ALMS1 FGFR2 IGF1R
5 homeostasis/metabolism MP:0005376 10.19 LEP ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R
6 endocrine/exocrine gland MP:0005379 10.18 ADIPOQ ALMS1 FGFR2 IGF1R INS INSR
7 immune system MP:0005387 10.18 ADIPOQ ALMS1 FGFR2 FGFR3 IGF1R INS
8 hematopoietic system MP:0005397 10.15 ADIPOQ FGFR2 FGFR3 IGF1R INS INSR
9 cardiovascular system MP:0005385 10.14 INS INSR LEP LMNA ADIPOQ FGFR2
10 digestive/alimentary MP:0005381 10.13 FGFR2 FGFR3 IGF1R INS INSR LEP
11 liver/biliary system MP:0005370 10.08 ADIPOQ ALMS1 FGFR2 IGF1R INS INSR
12 mortality/aging MP:0010768 10.06 ADIPOQ FGFR2 FGFR3 IGF1R INS INSR
13 integument MP:0010771 10.05 ADIPOQ FGFR2 FGFR3 IGF1R INS LEP
14 muscle MP:0005369 9.98 FGFR2 IGF1R INS INSR LEP LMNA
15 hearing/vestibular/ear MP:0005377 9.96 ALMS1 FGFR2 FGFR3 IGF1R LMNA
16 renal/urinary system MP:0005367 9.92 ADIPOQ ALMS1 FGFR2 FGFR3 INS INSR
17 nervous system MP:0003631 9.91 INSR LEP LMNA FGFR3 IGF1R INS
18 limbs/digits/tail MP:0005371 9.89 FGFR2 FGFR3 IGF1R LEP LMNA
19 reproductive system MP:0005389 9.86 ALMS1 FGFR2 FGFR3 IGF1R INS INSR
20 neoplasm MP:0002006 9.8 ADIPOQ FGFR2 FGFR3 IGF1R LEP
21 respiratory system MP:0005388 9.7 ADIPOQ FGFR2 FGFR3 IGF1R INSR LEP
22 skeleton MP:0005390 9.5 ADIPOQ FGFR2 FGFR3 IGF1R INS LEP
23 vision/eye MP:0005391 9.1 ALMS1 FGFR2 FGFR3 INS LEP LMNA

Drugs & Therapeutics for Acanthosis Nigricans

Drugs for Acanthosis Nigricans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
2 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Enclomiphene Investigational Phase 3,Phase 2 15690-57-0
5 Autoantibodies Phase 3
6 insulin Phase 3,Phase 2
7 Insulin, Globin Zinc Phase 3,Phase 2
8 Clomiphene Phase 3,Phase 2
9 Estrogen Antagonists Phase 3,Phase 2
10 Estrogen Receptor Modulators Phase 3,Phase 2
11 Estrogens Phase 3,Phase 2
12 Fertility Agents Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Selective Estrogen Receptor Modulators Phase 3,Phase 2
17 Zuclomiphene Phase 3,Phase 2
18 Aromatase Inhibitors Phase 3
19 Steroid Synthesis Inhibitors Phase 3
20
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
21
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
22 Antineoplastic Agents, Hormonal Phase 2
23 diuretics Phase 2
24 Diuretics, Potassium Sparing Phase 2
25 Mineralocorticoid Receptor Antagonists Phase 2
26 Mineralocorticoids Phase 2
27 Natriuretic Agents Phase 2
28 Citrate Nutraceutical Phase 2
29
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
30
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
31
Pyridoxal Approved, Nutraceutical 66-72-8 1050
32
Pyridoxine Approved, Nutraceutical, Vet_approved 65-23-6 1054
33 Antioxidants
34 Calcium, Dietary
35 Central Nervous System Depressants
36 Protective Agents
37 Vitamin B 6
38 Vitamin B Complex
39 Vitamins

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
2 Adjunctive Metformin Therapy in Double Diabetes Completed NCT01334125 Phase 3 Metformin;Placebo
3 Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome Recruiting NCT03135301 Phase 3 letrozole plus metformin;letrozole
4 Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed NCT00004311 Phase 2 leuprolide acetate;spironolactone
5 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2 CC;Placebo tablets;Metformin
6 Prevalence of Carbohydrate Intolerance in Lean and Obese Children Unknown status NCT00000112
7 Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia Completed NCT01125150 Metformin
8 Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism Completed NCT02604095

Search NIH Clinical Center for Acanthosis Nigricans

Cochrane evidence based reviews: acanthosis nigricans

Genetic Tests for Acanthosis Nigricans

Genetic tests related to Acanthosis Nigricans:

id Genetic test Affiliating Genes
1 Acanthosis Nigricans 29

Anatomical Context for Acanthosis Nigricans

MalaCards organs/tissues related to Acanthosis Nigricans:

39
Skin, Ovary, Lung, Liver, Prostate, Thyroid, B Cells

Publications for Acanthosis Nigricans

Articles related to Acanthosis Nigricans:

(show top 50) (show all 591)
id Title Authors Year
1
Mild achondroplasia/hypochondroplasia with acanthosis nigricans, normal development, and a p.Ser348Cys FGFR3 mutation. ( 28181399 )
2017
2
Gastric Cancer Associated With Malignant Acanthosis Nigricans. ( 28317636 )
2017
3
The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors. ( 28081576 )
2017
4
Terra Firma-Forme Dermatosis Misdiagnosed as Nevoid Acanthosis Nigricans. ( 28930108 )
2017
5
A study of the association of acanthosis nigricans with subclinical atherosclerosis. ( 28164885 )
2017
6
Arterial stiffening, insulin resistance and acanthosis nigricans in a community sample of adolescents with obesity. ( 28465605 )
2017
7
Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female. ( 28413386 )
2017
8
A Mutation in INSR in a Child Presenting with Severe Acanthosis Nigricans. ( 28663160 )
2017
9
Acanthosis Nigricans ( 28613711 )
2017
10
Acanthosis Nigricans and Its Response to Metformin. ( 28758315 )
2017
11
Association of metabolic syndrome with low birth weight, intake of high-calorie diets and acanthosis nigricans in children and adolescents with overweight and obesity. ( 28440765 )
2017
12
The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices. ( 28367214 )
2017
13
Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review. ( 28295566 )
2017
14
Effects of glycolic acid peeling on the cutaneous manifestation of generalized acanthosis nigricans caused by FGFR3 mutation: A report of one sporadic and two familial cases. ( 28620983 )
2017
15
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges. ( 28031729 )
2017
16
Successful Repigmentation of Vitiligo-Like Hypopigmentation in a Case of Acanthosis Nigricans. ( 28392666 )
2017
17
Paediatric obesity treatment had better outcomes when children were younger, well motivated and did not have acanthosis nigricans. ( 28685930 )
2017
18
Image Gallery: Generalized mucosal and cutaneous papillomatosis, a unique sign of malignant acanthosis nigricans. ( 28504375 )
2017
19
Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children. ( 28892990 )
2017
20
Acanthosis Nigricans associated with clear-cell renal cell carcinoma. ( 27284539 )
2016
21
Linear acanthosis nigricans on the anterior neck: Koebner phenomenon observed in a patient with acanthosis nigricans. ( 27569660 )
2016
22
Lelis Syndrome: A Rare Cause of Acanthosis Nigricans. ( 27595879 )
2016
23
Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease. ( 27051830 )
2016
24
Acanthosis nigricans in insulinoma: before and after successful surgical enucleation. ( 27836838 )
2016
25
ACANTHOSIS NIGRICANS AND SEVERE INSULIN RESISTANCE IN A BOY WITH ATAXIA. ( 27124696 )
2016
26
IMAGES IN CLINICAL MEDICINE. Acanthosis Nigricans and Insulin Resistance. ( 27305209 )
2016
27
Diffuse esophageal papillomatosis in a patient with acanthosis nigricans. ( 27167874 )
2016
28
Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans. ( 26860419 )
2016
29
Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR3 mutation. ( 26818779 )
2016
30
Unilateral nevoid acanthosis nigricans treated with CO2 laser. ( 27457822 )
2016
31
FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. ( 27190511 )
2016
32
A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism. ( 27505086 )
2016
33
Bilaterally mammary acanthosis nigricans as paraneoplastic manifestation of prostate adenocarcinoma. ( 27595210 )
2016
34
Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity. ( 26588491 )
2016
35
Acanthosis Nigricans as a Clinical Predictor of Insulin Resistance in Obese Children. ( 28090470 )
2016
36
Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial. ( 27999648 )
2016
37
Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific. ( 27631218 )
2016
38
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer. ( 27536145 )
2016
39
Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: a case report. ( 27987313 )
2016
40
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. ( 27746646 )
2016
41
Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection. ( 27598021 )
2016
42
A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR. ( 27990384 )
2016
43
Florid cutaneous manifestations with acanthosis nigricans in a lung cancer patient. ( 25734371 )
2015
44
Social anxiety, depression and self-esteem in obese adolescent girls with acanthosis nigricans. ( 25800478 )
2015
45
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. ( 25657419 )
2015
46
Acral Acanthosis Nigricans in a Case of Scleroderma. ( 26288450 )
2015
47
Unilateral nevoid acanthosis nigricans. ( 26123470 )
2015
48
Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. ( 25817595 )
2015
49
Familial hypochondroplasia and acanthosis nigricans with FGFR3 K650T mutation. ( 25809207 )
2015
50
Costello syndrome with severe nodulocystic acne: unexpected significant improvement of acanthosis nigricans after oral isotretinoin treatment. ( 25815234 )
2015

Variations for Acanthosis Nigricans

ClinVar genetic disease variations for Acanthosis Nigricans:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FGFR3 NM_000142.4(FGFR3): c.1948A> C (p.Lys650Gln) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889

Expression for Acanthosis Nigricans

Search GEO for disease gene expression data for Acanthosis Nigricans.

Pathways for Acanthosis Nigricans

Pathways related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 FGFR2 FGFR3 IGF1R INS INSR LEP
2
Show member pathways
12.84 FGFR2 FGFR3 IGF1R INS INSR
3
Show member pathways
12.68 FGFR2 FGFR3 IGF1R INSR
4
Show member pathways
12.61 ADIPOQ INS INSR LEP
5
Show member pathways
12.54 FGFR2 FGFR3 INS INSR
6
Show member pathways
12.5 FGFR2 FGFR3 IGF1R INS INSR
7 12.46 FGFR2 FGFR3 IGF1R INS INSR
8 12.3 ADIPOQ IGF1R INS INSR
9 12.24 FGFR2 FGFR3 IGF1R
10
Show member pathways
12.23 FGFR2 FGFR3 IGF1R INSR
11
Show member pathways
12.03 INS INSR LEP
12
Show member pathways
12.02 FGFR2 FGFR3 IGF1R INS INSR
13 11.93 FGFR2 FGFR3 IGF1R
14
Show member pathways
11.92 IGF1R INS INSR
15
Show member pathways
11.91 ADIPOQ IGF1R INS INSR
16
Show member pathways
11.87 FGFR2 FGFR3 IGF1R INSR LMNA
17
Show member pathways
11.86 IGF1R INS INSR
18 11.86 FGFR2 FGFR3 IGF1R INSR
19 11.79 ADIPOQ INS LEP LMNA
20
Show member pathways
11.77 ADIPOQ IGF1R INS INSR LEP
21 11.76 IGF1R INS INSR
22 11.73 ADIPOQ INS LEP
23
Show member pathways
11.73 ADIPOQ INS INSR
24 11.54 FGFR2 FGFR3 IGF1R INSR
25 11.37 IGF1R INS INSR
26 11.35 INS INSR LEP
27 11.21 INS INSR
28 11.1 INS INSR
29 11.03 ADIPOQ LEP
30 10.84 ADIPOQ INSR LEP
31 10.58 FGFR2 FGFR3 IGF1R INSR

GO Terms for Acanthosis Nigricans

Biological processes related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.94 FGFR2 FGFR3 IGF1R INSR
2 positive regulation of cell migration GO:0030335 9.8 IGF1R INS INSR
3 response to ethanol GO:0045471 9.75 ADIPOQ FGFR2 LEP
4 phosphatidylinositol-mediated signaling GO:0048015 9.73 FGFR2 FGFR3 IGF1R
5 positive regulation of protein kinase B signaling GO:0051897 9.72 INS INSR LEP
6 insulin receptor signaling pathway GO:0008286 9.7 IGF1R INS INSR
7 protein autophosphorylation GO:0046777 9.67 FGFR2 FGFR3 IGF1R INSR
8 bone mineralization GO:0030282 9.64 FGFR2 FGFR3
9 bone morphogenesis GO:0060349 9.63 FGFR2 FGFR3
10 glucose metabolic process GO:0006006 9.63 ADIPOQ INS LEP
11 positive regulation of cell proliferation GO:0008284 9.63 FGFR2 FGFR3 IGF1R INS INSR LEP
12 activation of protein kinase B activity GO:0032148 9.62 INS INSR
13 positive regulation of mitotic nuclear division GO:0045840 9.62 INS INSR
14 peptidyl-tyrosine phosphorylation GO:0018108 9.62 FGFR2 FGFR3 IGF1R INSR
15 positive regulation of glycolytic process GO:0045821 9.61 INS INSR
16 positive regulation of cellular protein metabolic process GO:0032270 9.61 ADIPOQ INS
17 regulation of fat cell differentiation GO:0045598 9.6 ALMS1 LEP
18 positive regulation of glycogen biosynthetic process GO:0045725 9.59 INS INSR
19 negative regulation of gluconeogenesis GO:0045721 9.58 ADIPOQ INS
20 positive regulation of DNA replication GO:0045740 9.58 IGF1R INS INSR
21 positive regulation of insulin receptor signaling pathway GO:0046628 9.57 INS LEP
22 positive regulation of phospholipase activity GO:0010518 9.54 FGFR2 FGFR3
23 endochondral bone growth GO:0003416 9.51 FGFR2 FGFR3
24 regulation of protein localization to nucleus GO:1900180 9.49 LEP LMNA
25 positive regulation of respiratory burst GO:0060267 9.48 INS INSR
26 positive regulation of developmental growth GO:0048639 9.43 INSR LEP
27 positive regulation of glucose import GO:0046326 9.43 ADIPOQ INS INSR
28 glucose homeostasis GO:0042593 9.35 ADIPOQ ALMS1 INS INSR LEP
29 positive regulation of MAPK cascade GO:0043410 9.02 FGFR2 FGFR3 INS INSR LEP

Molecular functions related to Acanthosis Nigricans according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.8 FGFR2 FGFR3 IGF1R INSR
2 insulin receptor binding GO:0005158 9.51 IGF1R INS
3 hormone activity GO:0005179 9.5 ADIPOQ INS LEP
4 fibroblast growth factor binding GO:0017134 9.48 FGFR2 FGFR3
5 phosphatidylinositol 3-kinase binding GO:0043548 9.46 IGF1R INSR
6 insulin-like growth factor receptor binding GO:0005159 9.43 INS INSR
7 insulin receptor substrate binding GO:0043560 9.4 IGF1R INSR
8 insulin-like growth factor I binding GO:0031994 9.37 IGF1R INSR
9 fibroblast growth factor-activated receptor activity GO:0005007 9.26 FGFR2 FGFR3
10 protein tyrosine kinase activity GO:0004713 9.26 FGFR2 FGFR3 IGF1R INSR
11 insulin binding GO:0043559 9.16 IGF1R INSR
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 FGFR2 FGFR3 IGF1R INSR

Sources for Acanthosis Nigricans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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