MCID: ACN001
MIFTS: 55

Acinar Cell Carcinoma malady

Rare diseases, Cancer diseases categories

Summaries for Acinar Cell Carcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards: Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatitis and pituitary adenoma. An important gene associated with Acinar Cell Carcinoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are LKB1 signaling events and Canonical Wnt signaling pathway. The compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:66 Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour... more...

Aliases & Classifications for Acinar Cell Carcinoma

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9Disease Ontology, 11DISEASES, 63UMLS, 44NIH Rare Diseases, 46Novoseek, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

acinar cell carcinoma 9 11 63
acinic cell carcinoma 9 44
carcinoma acinar cell 46
acinic cell tumor 44


External Ids:

Disease Ontology9 DOID:3025
MeSH36 D018267
SNOMED-CT59 45410002
NCIt41 C3768

Related Diseases for Acinar Cell Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.7PLA2G1B, REG1A, SMAD4
2pituitary adenoma30.6APC, CHGA, SYP
3adenocarcinoma30.4REG1A, CHGA, AFP, SMAD4, APC, CEACAM5
4hypoglycemia30.3IGF2, STK11, CHGA
5pancreatic cancer30.3SMAD4, CEACAM5, STK11
6adenoma30.2SMAD4, CEACAM5, STK11, REG1A, APC, CHGA
7hepatocellular carcinoma29.9STK11, SMAD4, AFP, APC, REG1A, CEACAM5
8panniculitis10.5
9pancreatoblastoma10.4
10duodenitis10.3
11hepatitis10.3
12microglandular adenosis10.2
13neurofibroma10.2
14acute pancreatitis10.2
15portal hypertension10.2
16cushing's syndrome10.2
17pancreatic acinar cell adenocarcinoma10.2
18hypertension10.2
19islet cell tumor10.2
20leukemia10.2
21lymphoblastic leukemia10.2
22myeloma10.2
23neuroendocrine tumor10.2
24obesity10.2
25peritonitis10.2
26glucagonoma10.2
27extragonadal germ cell tumor10.1AFP
28sertoli cell tumor10.1SYP
29intussusception10.1STK11
30polyhydramnios10.1AFP
31neuroblastoma10.1SYP
32dysembryoplastic neuroepithelial tumor10.1SYP
33edwards syndrome10.1BCL10, AFP
34hemihypertrophy10.1IGF2
35central neurocytoma10.1SYP, CHGA
36pancreatic islet cell tumors10.1CHGA, SYP
37endocrine gland cancer10.1SYP, CHGA
38pineocytoma10.1SYP, CHGA
39merkel cell carcinoma10.1CHGA, SYP
40pancreatic ductal carcinoma10.1SMAD4, CHGA
41vipoma10.1SMAD4, CHGA
42hyperinsulinemic hypoglycemia10.1CHGA, IGF2
43omphalocele10.1AFP, IGF2
44ganglioglioma10.1CHGA, SYP
45pancreas disease10.1REG1A, SMAD4
46cowden disease10.1SMAD4, STK11
47choroid plexus papilloma10.1SYP, IGF2
48signet ring cell adenocarcinoma10.1CEACAM5, CHGA
49malignant mixed mullerian tumor10.1CTNNB1, AFP
50ganglioneuroma10.1CHGA, SYP

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to acinar cell carcinoma

Symptoms for Acinar Cell Carcinoma

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Drugs & Therapeutics for Acinar Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acinar Cell Carcinoma

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Anatomical Context for Acinar Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Acinar Cell Carcinoma:

34
Pancreas, Liver, Skin, Brain, Ovary

Animal Models for Acinar Cell Carcinoma or affiliated genes

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38MGI
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Publications for Acinar Cell Carcinoma

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53PubMed
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Articles related to Acinar Cell Carcinoma:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Acinar cell carcinoma of the pancreas: clinical and cytomorphologic characteristics. (23667367)
2013
2
Primary acinar cell carcinoma of the liver. (23440644)
2013
3
"Chronic" metastatic pancreatic acinar cell carcinoma. (24075523)
2013
4
Acinar cell carcinoma presenting as a duodenal mass: review of the literature and a case report. (23550393)
2013
5
A case report of a patient with advanced acinar cell carcinoma of the pancreas: long-term survival with regional, systemic and targeted therapy. (23748831)
2013
6
CT imaging features of acinar cell carcinoma and its hepatic metastases. (23232580)
2013
7
Use of panitumumab in the treatment of acinar cell carcinoma of the pancreas: A case report. (23426888)
2013
8
Pancreatic panniculitis secondary to acinar cell carcinoma of the pancreas. (23763078)
2013
9
BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. (23530562)
2013
10
Endoscopic ultrasound image of alpha-fetoprotein-producing pancreatic acinar cell carcinoma. (21944950)
2012
11
Multimodal treatment of hepatic metastasis in the form of a bile duct tumor thrombus from pancreatic acinar cell carcinoma: case report of successful resection after chemoradiation therapy. (22949891)
2012
12
Image of the month: Cystic variant of pancreatic acinar cell carcinoma. (22582413)
2012
13
Pancreatic acinar cell carcinoma. (21982066)
2012
14
FOLFOX regimen in pancreatic acinar cell carcinoma: case report and review of the literature. (21961498)
2012
15
Intraductal polypoid growth variant of pancreatic acinar cell carcinoma metastasizing to the intrahepatic bile duct 6 years after surgery: a case report and literature review. (22487469)
2012
16
Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3). (22687839)
2012
17
Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature. (19584100)
2011
18
Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. (21893434)
2011
19
Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis. (21546712)
2011
20
Image of the month. Acinar cell carcinoma. (21931007)
2011
21
Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. (21572398)
2011
22
Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. (20534994)
2010
23
A case of pancreatic acinar cell carcinoma metastatic to skin. (21234254)
2010
24
Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst. (20090274)
2010
25
Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa. (19144387)
2009
26
Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy. (19239719)
2009
27
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. (18724247)
2008
28
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
29
Long-term survival in a patient with acinar cell carcinoma of pancreas. A case report and review of literature. (17993731)
2007
30
A long-term survivor of metastatic acinar cell carcinoma. (17312470)
2007
31
Pancreatic acinar cell carcinoma with intracranial metastasis in a dog. (17283409)
2007
32
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. (17196112)
2006
33
Acinar cell carcinoma of the pancreas in a young patient with cells immunoreactive for somatostatin. (16430479)
2006
34
Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts. (16984622)
2006
35
Intraductal acinar cell carcinoma of the pancreas. (11315630)
2001
36
Acinar cell carcinoma of the pancreas successfully treated by en bloc resection and intraperitoneal chemotherapy for peritoneal relapse: a case report of a 15-year survivor. (11451140)
2001
37
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. (10982618)
2000
38
Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II. (9773947)
1998
39
Functioning pancreatic acinar cell carcinoma: immunohistochemical and ultrastructural analyses. (9020300)
1997
40
Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. (9067100)
1997
41
Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation. (7541276)
1995
42
Acinar cell carcinoma of the pancreas: a rare cause of left-sided portal hypertension. (1858743)
1991
43
Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. (3542187)
1987
44
Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. (3940400)
1986
45
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification. (3741765)
1986
46
Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism. (6494735)
1984
47
Acinar cell carcinoma of the pancreas in a cat. (473484)
1979
48
Pancreatic acinar cell carcinoma in childhood. (4834991)
1974
49
Acinar cell carcinoma of the pancreas with subcutaneous fat necrosis. (5853162)
1965
50
Functioning acinar cell carcinoma of the pancreas. (14011794)
1962

Variations for Acinar Cell Carcinoma

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Expression for genes affiliated with Acinar Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for genes affiliated with Acinar Cell Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 55R&D Systems, 31KEGG, 61Thomson Reuters, 54QIAGEN
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Pathways related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8STK11, SMAD4
29.7CTNNB1, APC
39.5SMAD4, STK11, CTNNB1
49.5CTNNB1, STK11, SMAD4
59.4CTNNB1, APC, AFP
6
Show member pathways
Wnt Signaling Pathway NetPath39
9.3SMAD4, APC, CTNNB1
79.3CTNNB1, APC, SMAD4
8
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.3CTNNB1, APC, SMAD4
9
Show member pathways
Signal transduction PTEN pathway61
9.3CTNNB1, APC, SMAD4
109.2IGF2, APC, CTNNB1
119.1CTNNB1, APC, AFP, SMAD4
129.0CTNNB1, STK11, APC, SMAD4

Compounds for genes affiliated with Acinar Cell Carcinoma

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Sources:
46Novoseek, 3BitterDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4610.0CTNNB1, APC
21-hydroxyanthraquinone4610.0APC, CTNNB1
3samp469.9APC, CTNNB1
4smcc469.9SYP, CHGA
5sodium bisulfite469.6IGF2, CTNNB1, APC
61,2-dimethylhydrazine469.6APC, CTNNB1
7b 723469.5AFP, SYP, CEACAM5, CHGA
8hematoxylin469.5CHGA, SYP, CEACAM5
9silver469.5SYP, CEACAM5, AFP, CHGA
10gold469.4SYP, CEACAM5, AFP, CHGA
11chloramphenicol46 3 52 1212.4CHGA, AFP, SMAD4, IGF2
12tgf beta1469.4CTNNB1, IGF2, AFP, SMAD4
13etoposide46 52 62 1212.3IGF2, SYP, CHGA, AFP
14gnrh469.3SMAD4, IGF2, CHGA, CTNNB1
15acth469.3APC, IGF2, SYP, CHGA
165-aza-2deoxycytidine469.2CTNNB1, STK11, APC, IGF2
17crcs469.2CTNNB1, CEACAM5, SMAD4, APC
18p002469.2CHGA, CTNNB1, CEACAM5, IGF2
19phosphoserine46 2510.2REG1A, APC, CEACAM5
20paclitaxel46 52 1211.2CHGA, CTNNB1, IGF2, AFP
215fluorouracil469.1AFP, IGF2, CTNNB1, CEACAM5
22vitamin d469.1IGF2, APC, AFP, CTNNB1, CHGA
23lithium46 52 25 1212.1APC, SYP, CTNNB1
24norepinephrine46 25 1211.0IGF2, APC, CHGA, SYP
25butyrate469.0CTNNB1, IGF2, AFP, CEACAM5
26glutamine469.0CTNNB1, AFP, APC, SYP, IGF2
27agar468.9IGF2, SMAD4, AFP, CEACAM5, CTNNB1
28alanine468.8IGF2, CTNNB1, STK11, BCL10, AFP, SMAD4
29guanine46 25 1210.8IGF2, SYP, STK11, CTNNB1, CHGA, APC
30oligonucleotide468.7SMAD4, CHGA, APC, AFP, IGF2, CTNNB1
31retinoic acid46 259.7CTNNB1, SYP, CHGA, APC, IGF2, AFP
32cisplatin46 52 62 1211.7AFP, CHGA, CEACAM5, SYP, CTNNB1, IGF2
33h2o2468.5IGF2, AFP, CTNNB1, PLA2G1B, SYP
34testosterone46 62 25 1211.4CHGA, IGF2, SMAD4, AFP, APC, CTNNB1
35estradiol46 25 1210.4SYP, CEACAM5, AFP, IGF2, PLA2G1B
36fatty acid468.4AFP, STK11, APC, PLA2G1B, CTNNB1, CHGA
37thymidine46 259.4AFP, IGF2, SMAD4, REG1A, CEACAM5, CTNNB1
38steroid468.3CTNNB1, SYP, CEACAM5, CHGA, SMAD4, IGF2
39dexamethasone46 52 30 1211.3CHGA, SYP, IGF2, CTNNB1, AFP, PLA2G1B
40lactate468.2IGF2, SMAD4, AFP, CHGA, CEACAM5, PLA2G1B
41vegf468.0CTNNB1, CHGA, SMAD4, STK11, AFP, IGF2
42glycogen46 259.0AFP, IGF2, SYP, STK11, CEACAM5, CHGA
43estrogen467.9IGF2, SYP, CEACAM5, AFP, APC, SMAD4
44glucose467.8IGF2, SMAD4, AFP, APC, REG1A, STK11
45lipid467.7BCL10, SYP, PLA2G1B, STK11, CEACAM5, APC
46paraffin467.6CTNNB1, CEACAM5, CHGA, APC, STK11, AFP
47progesterone46 30 62 25 1211.5IGF2, CTNNB1, SYP, PLA2G1B, CHGA, CEACAM5
48calcium46 52 25 1210.4CHGA, APC, CEACAM5, SYP, STK11, AFP
49serine466.8CTNNB1, IGF2, AFP, SYP, STK11, REG1A
50tyrosine466.6AFP, SYP, CTNNB1, CEACAM5, REG1A, CHGA

GO Terms for genes affiliated with Acinar Cell Carcinoma

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17Gene Ontology
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Cellular components related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.7CTNNB1, APC
2lateral plasma membraneGO:0163289.7CTNNB1, APC
3cell-cell adherens junctionGO:0059139.6CTNNB1, APC
4cytosolGO:0058297.9SMAD4, APC, RNPS1, STK11, BCL10, CTNNB1

Biological processes related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:06039510.0SMAD4, AFP
2negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.0STK11, APC
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.9STK11, SMAD4
4canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:0443369.9CTNNB1, APC
5gastrulation with mouth forming secondGO:0017029.8CTNNB1, SMAD4
6proximal/distal pattern formationGO:0099549.7CTNNB1, APC
7thymus developmentGO:0485389.7CTNNB1, APC
8cellular response to mechanical stimulusGO:0712609.6CTNNB1, BCL10, IGF2
9canonical Wnt signaling pathwayGO:0600709.6APC, STK11, CTNNB1
10T cell differentiation in thymusGO:0330779.6APC, CTNNB1
11negative regulation of cell proliferationGO:0082859.2CTNNB1, STK11, APC, SMAD4
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.2CTNNB1, PLA2G1B, SMAD4, IGF2

Molecular functions related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:0704119.8CTNNB1, SMAD4
2cadherin bindingGO:0452969.7CTNNB1, APC
3R-SMAD bindingGO:0704129.7CTNNB1, SMAD4
4protein complex bindingGO:0324039.2CTNNB1, SYP, STK11

Products for genes affiliated with Acinar Cell Carcinoma

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Sources for Acinar Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet