MCID: ACN001
MIFTS: 46

Acinar Cell Carcinoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Acinar Cell Carcinoma

About this section

Acinar Cell Carcinoma, Aliases & Descriptions:

Name: Acinar Cell Carcinoma 9 11 60
Acinic Cell Carcinoma 9 41
Carcinoma Acinar Cell 43
 
Acinic Cell Tumor 41
Acinar Cell Tumor 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:3025
MeSH33 D018267
SNOMED-CT55 45410002
NCIt38 C3768

Summaries for Acinar Cell Carcinoma

About this section


Disease Ontology:9 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards based summary: Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatitis and islet cell tumor. An important gene associated with Acinar Cell Carcinoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are LKB1 signaling events and Canonical Wnt signaling pathway. The compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Related Diseases for Acinar Cell Carcinoma

About this section

Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.9PLA2G1B, REG1A, SMAD4
2islet cell tumor30.8CHGA, SYP
3pituitary adenoma30.6SYP, CHGA, APC
4hypoglycemia30.5STK11, CHGA, IGF2
5neuroendocrine tumor30.5CHGA, CEACAM5, SYP
6pancreatic cancer30.3SMAD4, CEACAM5, STK11
7adenocarcinoma29.3SMAD4, AFP, APC, CHGA, REG1A, CEACAM5
8adenoma29.0IGF2, SMAD4, APC, CHGA, REG1A, CEACAM5
9hepatocellular carcinoma28.7IGF2, SMAD4, AFP, APC, REG1A, CEACAM5
10panniculitis10.5
11extragonadal germ cell tumor10.5AFP
12sertoli cell tumor10.5SYP
13intussusception10.5STK11
14polyhydramnios10.5AFP
15neuroblastoma10.5SYP
16dysembryoplastic neuroepithelial tumor10.4SYP
17pancreatoblastoma10.4
18edwards syndrome10.4AFP, BCL10
19hemi 3 syndrome10.4IGF2
20central neurocytoma10.4CHGA, SYP
21endocrine gland cancer10.4CHGA, SYP
22pineocytoma10.4CHGA, SYP
23hepatitis10.3
24duodenitis10.3
25peritonitis10.3
26pancreatic ductal carcinoma10.3SMAD4, CHGA
27merkel cell carcinoma10.3SYP, CHGA
28vipoma10.3SMAD4, CHGA
29hyperinsulinemic hypoglycemia, familial, 210.3IGF2, CHGA
30omphalocele10.3IGF2, AFP
31ganglioglioma10.3SYP, CHGA
32pancreas disease10.3SMAD4, REG1A
33cowden disease10.3STK11, SMAD4
34choroid plexus papilloma10.3IGF2, SYP
35signet ring cell adenocarcinoma10.3CHGA, CEACAM5
36malignant mixed mullerian tumor10.3AFP, CTNNB1
37ganglioneuroma10.2CHGA, SYP
38microglandular adenosis10.2
39neurofibroma10.2
40superior vena cava syndrome10.2
41rhabdoid tumor10.2SYP, IGF2
42endodermal sinus tumor10.2AFP, CEACAM5
43papillary carcinoma10.2SMAD4, CHGA, SYP
44obesity10.2
45leukemia10.2
46skin conditions10.2
47portal hypertension10.2
48cushing's syndrome10.2
49pancreatic acinar cell adenocarcinoma10.2
50lymphoblastic leukemia10.2

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to acinar cell carcinoma

Symptoms for Acinar Cell Carcinoma

About this section

Drugs & Therapeutics for Acinar Cell Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Acinar Cell Carcinoma

Search NIH Clinical Center for Acinar Cell Carcinoma

Genetic Tests for Acinar Cell Carcinoma

About this section

Anatomical Context for Acinar Cell Carcinoma

About this section

MalaCards organs/tissues related to Acinar Cell Carcinoma:

31
Pancreas, Liver, Skin, Brain, Colon, Ovary

Animal Models for Acinar Cell Carcinoma or affiliated genes

About this section

Publications for Acinar Cell Carcinoma

About this section

Articles related to Acinar Cell Carcinoma:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Acinar cell carcinoma of the pancreas: clinical and cytomorphologic characteristics. (23667367)
2013
2
Primary acinar cell carcinoma of the liver. (23440644)
2013
3
"Chronic" metastatic pancreatic acinar cell carcinoma. (24075523)
2013
4
Acinar cell carcinoma presenting as a duodenal mass: review of the literature and a case report. (23550393)
2013
5
A case report of a patient with advanced acinar cell carcinoma of the pancreas: long-term survival with regional, systemic and targeted therapy. (23748831)
2013
6
CT imaging features of acinar cell carcinoma and its hepatic metastases. (23232580)
2013
7
Use of panitumumab in the treatment of acinar cell carcinoma of the pancreas: A case report. (23426888)
2013
8
Acinar cell carcinoma: a rare pancreatic malignancy. (24765506)
2013
9
Pancreatic panniculitis secondary to acinar cell carcinoma of the pancreas. (23763078)
2013
10
BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. (23530562)
2013
11
Endoscopic ultrasound image of alpha-fetoprotein-producing pancreatic acinar cell carcinoma. (21944950)
2012
12
Multimodal treatment of hepatic metastasis in the form of a bile duct tumor thrombus from pancreatic acinar cell carcinoma: case report of successful resection after chemoradiation therapy. (22949891)
2012
13
Image of the month: Cystic variant of pancreatic acinar cell carcinoma. (22582413)
2012
14
Pancreatic acinar cell carcinoma. (21982066)
2012
15
FOLFOX regimen in pancreatic acinar cell carcinoma: case report and review of the literature. (21961498)
2012
16
Intraductal polypoid growth variant of pancreatic acinar cell carcinoma metastasizing to the intrahepatic bile duct 6 years after surgery: a case report and literature review. (22487469)
2012
17
Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3). (22687839)
2012
18
Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature. (19584100)
2011
19
Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. (21893434)
2011
20
Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis. (21546712)
2011
21
Image of the month. Acinar cell carcinoma. (21931007)
2011
22
Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. (20534994)
2010
23
A case of pancreatic acinar cell carcinoma metastatic to skin. (21234254)
2010
24
Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst. (20090274)
2010
25
Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa. (19144387)
2009
26
Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy. (19239719)
2009
27
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. (18724247)
2008
28
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
29
Long-term survival in a patient with acinar cell carcinoma of pancreas. A case report and review of literature. (17993731)
2007
30
A long-term survivor of metastatic acinar cell carcinoma. (17312470)
2007
31
Pancreatic acinar cell carcinoma with intracranial metastasis in a dog. (17283409)
2007
32
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. (17196112)
2006
33
Acinar cell carcinoma of the pancreas in a young patient with cells immunoreactive for somatostatin. (16430479)
2006
34
Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts. (16984622)
2006
35
Intraductal acinar cell carcinoma of the pancreas. (11315630)
2001
36
Acinar cell carcinoma of the pancreas successfully treated by en bloc resection and intraperitoneal chemotherapy for peritoneal relapse: a case report of a 15-year survivor. (11451140)
2001
37
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. (10982618)
2000
38
Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II. (9773947)
1998
39
Functioning pancreatic acinar cell carcinoma: immunohistochemical and ultrastructural analyses. (9020300)
1997
40
Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. (9067100)
1997
41
Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation. (7541276)
1995
42
Acinar cell carcinoma of the pancreas: a rare cause of left-sided portal hypertension. (1858743)
1991
43
Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. (3542187)
1987
44
Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. (3940400)
1986
45
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification. (3741765)
1986
46
Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism. (6494735)
1984
47
Acinar cell carcinoma of the pancreas in a cat. (473484)
1979
48
Pancreatic acinar cell carcinoma in childhood. (4834991)
1974
49
Acinar cell carcinoma of the pancreas with subcutaneous fat necrosis. (5853162)
1965
50
Functioning acinar cell carcinoma of the pancreas. (14011794)
1962

Variations for Acinar Cell Carcinoma

About this section

Expression for genes affiliated with Acinar Cell Carcinoma

About this section
Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for genes affiliated with Acinar Cell Carcinoma

About this section

Pathways related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8STK11, SMAD4
29.7CTNNB1, APC
39.5SMAD4, STK11, CTNNB1
49.5CTNNB1, STK11, SMAD4
59.4CTNNB1, APC, AFP
6
Show member pathways
Wnt Signaling Pathway NetPath36
9.3SMAD4, APC, CTNNB1
79.3CTNNB1, APC, SMAD4
8
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.3CTNNB1, APC, SMAD4
9
Show member pathways
Signal transduction PTEN pathway58
9.3CTNNB1, APC, SMAD4
109.2IGF2, APC, CTNNB1
119.1CTNNB1, APC, AFP, SMAD4
129.0CTNNB1, STK11, APC, SMAD4

Compounds for genes affiliated with Acinar Cell Carcinoma

About this section

Compounds related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4310.0CTNNB1, APC
21-hydroxyanthraquinone4310.0APC, CTNNB1
3samp439.9APC, CTNNB1
4smcc439.9SYP, CHGA
5sodium bisulfite439.6IGF2, CTNNB1, APC
61,2-dimethylhydrazine439.6APC, CTNNB1
7b 723439.5AFP, SYP, CEACAM5, CHGA
8hematoxylin439.5CHGA, SYP, CEACAM5
9silver439.5SYP, CEACAM5, AFP, CHGA
10gold439.4SYP, CEACAM5, AFP, CHGA
11chloramphenicol43 2 49 1212.4CHGA, AFP, SMAD4, IGF2
12tgf beta1439.4CTNNB1, IGF2, AFP, SMAD4
13etoposide43 49 59 1212.3IGF2, SYP, CHGA, AFP
14gnrh439.3SMAD4, IGF2, CHGA, CTNNB1
15acth439.3APC, IGF2, SYP, CHGA
165-aza-2deoxycytidine439.2CTNNB1, STK11, APC, IGF2
17crcs439.2CTNNB1, CEACAM5, SMAD4, APC
18p002439.2CHGA, CTNNB1, CEACAM5, IGF2
19phosphoserine43 2410.2REG1A, APC, CEACAM5
20paclitaxel43 49 1211.2CHGA, CTNNB1, IGF2, AFP
215fluorouracil439.1AFP, IGF2, CTNNB1, CEACAM5
22vitamin d439.1IGF2, APC, AFP, CTNNB1, CHGA
23lithium43 49 24 1212.1APC, SYP, CTNNB1
24norepinephrine43 24 1211.0IGF2, APC, CHGA, SYP
25butyrate439.0CTNNB1, IGF2, AFP, CEACAM5
26glutamine439.0CTNNB1, AFP, APC, SYP, IGF2
27agar438.9IGF2, SMAD4, AFP, CEACAM5, CTNNB1
28alanine438.8IGF2, CTNNB1, STK11, BCL10, AFP, SMAD4
29guanine43 24 1210.8IGF2, SYP, STK11, CTNNB1, CHGA, APC
30oligonucleotide438.7SMAD4, CHGA, APC, AFP, IGF2, CTNNB1
31retinoic acid43 249.7CTNNB1, SYP, CHGA, APC, IGF2, AFP
32cisplatin43 49 59 1211.7AFP, CHGA, CEACAM5, SYP, CTNNB1, IGF2
33h2o2438.5IGF2, AFP, CTNNB1, PLA2G1B, SYP
34testosterone43 59 24 1211.4CHGA, IGF2, SMAD4, AFP, APC, CTNNB1
35estradiol43 24 1210.4SYP, CEACAM5, AFP, IGF2, PLA2G1B
36fatty acid438.4AFP, STK11, APC, PLA2G1B, CTNNB1, CHGA
37thymidine43 249.4AFP, IGF2, SMAD4, REG1A, CEACAM5, CTNNB1
38steroid438.3CTNNB1, SYP, CEACAM5, CHGA, SMAD4, IGF2
39dexamethasone43 49 28 1211.3CHGA, SYP, IGF2, CTNNB1, AFP, PLA2G1B
40lactate438.2IGF2, SMAD4, AFP, CHGA, CEACAM5, PLA2G1B
41vegf438.0CTNNB1, CHGA, SMAD4, STK11, AFP, IGF2
42glycogen43 249.0AFP, IGF2, SYP, STK11, CEACAM5, CHGA
43estrogen437.9IGF2, SYP, CEACAM5, AFP, APC, SMAD4
44glucose437.8IGF2, SMAD4, AFP, APC, REG1A, STK11
45lipid437.7BCL10, SYP, PLA2G1B, STK11, CEACAM5, APC
46paraffin437.6CTNNB1, CEACAM5, CHGA, APC, STK11, AFP
47progesterone43 28 59 24 1211.5IGF2, CTNNB1, SYP, PLA2G1B, CHGA, CEACAM5
48calcium43 49 24 1210.4CHGA, APC, CEACAM5, SYP, STK11, AFP
49serine436.8CTNNB1, IGF2, AFP, SYP, STK11, REG1A
50tyrosine436.6AFP, SYP, CTNNB1, CEACAM5, REG1A, CHGA

GO Terms for genes affiliated with Acinar Cell Carcinoma

About this section

Cellular components related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:00308779.7CTNNB1, APC
2lateral plasma membraneGO:00163289.7CTNNB1, APC
3cell-cell adherens junctionGO:00059139.6CTNNB1, APC
4cytosolGO:00058297.9SMAD4, APC, RNPS1, STK11, BCL10, CTNNB1

Biological processes related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:006039510.0SMAD4, AFP
2negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:006077010.0STK11, APC
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:00305119.9STK11, SMAD4
4canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:00443369.9CTNNB1, APC
5gastrulation with mouth forming secondGO:00017029.8CTNNB1, SMAD4
6proximal/distal pattern formationGO:00099549.7CTNNB1, APC
7thymus developmentGO:00485389.7CTNNB1, APC
8cellular response to mechanical stimulusGO:00712609.6CTNNB1, BCL10, IGF2
9canonical Wnt signaling pathwayGO:00600709.6APC, STK11, CTNNB1
10T cell differentiation in thymusGO:00330779.6APC, CTNNB1
11negative regulation of cell proliferationGO:00082859.2CTNNB1, STK11, APC, SMAD4
12positive regulation of transcription from RNA polymerase II promoterGO:00459448.2CTNNB1, PLA2G1B, SMAD4, IGF2

Molecular functions related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:00704119.8CTNNB1, SMAD4
2cadherin bindingGO:00452969.7CTNNB1, APC
3R-SMAD bindingGO:00704129.7CTNNB1, SMAD4
4protein complex bindingGO:00324039.2CTNNB1, SYP, STK11

Products for genes affiliated with Acinar Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acinar Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet