MCID: ACN001
MIFTS: 51

Acinar Cell Carcinoma malady

Cancer diseases category

Summaries for Acinar Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards: Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatitis and adenocarcinoma. An important gene associated with Acinar Cell Carcinoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are Wnt / Hedgehog / Notch and Endometrial cancer. The compounds guanine and smcc have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour... more...

Aliases & Classifications for Acinar Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

acinar cell carcinoma 8 10 60
acinic cell carcinoma 8 42
carcinoma acinar cell 44
acinic cell tumor 42


External Ids:

Disease Ontology8 DOID:3025
NCIt39 C3768
SNOMED-CT56 45410002
MeSH34 D018267

Related Diseases for Acinar Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.5SMAD4, PLA2G1B, REG1A
2adenocarcinoma30.6APC, CTNNB1, STK11, AFP, SYP, CHGA
3pituitary adenoma30.5APC, SYP, CHGA
4adenoma30.4APC, CTNNB1, STK11, SMAD4, CEACAM5, REG1A
5hepatitis30.4AFP
6large cell carcinoma30.4SYP, CHGA, CEACAM5
7neuroendocrine carcinoma30.4CEACAM5, CHGA, SYP
8neuroendocrine tumor30.2CHGA
9pancreas disease30.2REG1A, SMAD4
10pancreatic ductal carcinoma30.2CHGA, SMAD4
11leukemia30.2BCL10
12papillary carcinoma30.1SMAD4, CHGA, SYP
13pancreatic cancer30.1CTNNB1, STK11, CHGA, REG1A, CEACAM5, SMAD4
14hepatocellular carcinoma30.1APC, CTNNB1, STK11, AFP, IGF2, REG1A
15panniculitis10.5
16pancreas adenocarcinoma10.4
17acinic cell breast carcinoma10.4
18pancreatic acinar cell adenocarcinoma10.4
19pancreatoblastoma10.4
20bile duct carcinoma10.4
21acute pancreatitis10.3
22pancreatic endocrine carcinoma10.3
23duodenitis10.3
24microglandular adenosis of breast10.2
25basal cell carcinoma10.2
26microglandular adenosis10.2
27neurofibroma10.2
28ductal carcinoma in situ10.1
29cushing's syndrome10.1
30pleomorphic carcinoma10.1
31portal hypertension10.1
32hypoglycemia10.1
33adenocarcinoma in situ10.1
34acute leukemia10.1
35hepatitis a10.1
36childhood leukemia10.1
37hypertension10.1
38in situ carcinoma10.1
39islet cell tumor10.1
40lymphoblastic leukemia10.1
41myeloma10.1
42obesity10.1
43peritonitis10.1
44pulmonary neuroendocrine tumor10.1
45parathyroid adenoma10.0CHGA
46sertoli cell tumor10.0SYP
47multiple endocrine neoplasia10.0CHGA
48extragonadal germ cell tumor10.0AFP
49diabetes mellitus10.0REG1A
50phaeochromocytoma10.0CHGA

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to acinar cell carcinoma

Clinical Features for Acinar Cell Carcinoma

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Drugs & Therapeutics for Acinar Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acinar Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Acinar Cell Carcinoma

Search NIH Clinical Center for Acinar Cell Carcinoma

Search CenterWatch for Acinar Cell Carcinoma

Genetic Tests for Acinar Cell Carcinoma

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Anatomical Context for Acinar Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Acinar Cell Carcinoma:

32
Pancreas, Liver, Skin, Brain, Colon, Ovary

Animal Models for Acinar Cell Carcinoma or affiliated genes

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36MGI
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Publications for Acinar Cell Carcinoma

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50PubMed
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Articles related to Acinar Cell Carcinoma:

(show top 50)    (show all 179)
idTitleAuthorsYear
1
"Chronic" metastatic pancreatic acinar cell carcinoma. (24075523)
2013
2
Acinar cell carcinoma presenting as a duodenal mass: review of the literature and a case report. (23550393)
2013
3
A case report of a patient with advanced acinar cell carcinoma of the pancreas: long-term survival with regional, systemic and targeted therapy. (23748831)
2013
4
Brush cytology of acinar cell carcinoma of the pancreas with intraductal growth: A case report. (24376257)
2013
5
FOLFOX regimen in pancreatic acinar cell carcinoma: case report and review of the literature. (21961498)
2012
6
Pure pancreatic-type acinar cell carcinoma of the stomach: a case report. (22467716)
2012
7
Acinar cell carcinoma of the pancreas: a possible role of S-1 as chemotherapy for acinar cell carcinoma. A case report. (22233955)
2012
8
Spontaneous rupture of a pancreatic acinar cell carcinoma presenting as an acute abdomen. (22543229)
2012
9
Image of the month. Acinar cell carcinoma. (21931007)
2011
10
Pancreatic panniculitis associated with acinar cell carcinoma of the pancreas: a case report. (21747626)
2011
11
Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review. (20803029)
2011
12
A case of pancreatic acinar cell carcinoma metastatic to skin. (21234254)
2010
13
Acinar cell carcinoma of the pancreas in a young patient with chronic pancreatitis. (20133240)
2010
14
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. (20182344)
2010
15
Acinar cell carcinoma of the pancreas with intraductal growth: report of a case. (19882327)
2009
16
Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. (19720778)
2009
17
Metastatic acinar cell carcinoma of the pancreas responding to gemcitabine, 5-fluorouracil and leucovorin therapy: a case report. (19445023)
2009
18
A spontaneous acinar cell carcinoma model for monitoring progression of pancreatic lesions and response to treatment through noninvasive bioluminescence imaging. (19622581)
2009
19
Acinar cell carcinoma versus solid pseudopapillary tumor of the pancreas in children: a comparison of two rare and overlapping entities with review of the literature. (19006424)
2008
20
672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. (18656619)
2008
21
Primary acinar cell carcinoma of the liver. (18193278)
2008
22
Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression. (17703084)
2007
23
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. (17196112)
2006
24
Acinar cell carcinoma of the pancreas in a young patient with cells immunoreactive for somatostatin. (16430479)
2006
25
DNA quantification as prognostic factor in a case of acinar cell carcinoma of the parotid gland, diagnosed by FNA. (16056182)
2005
26
CT and MRI features of pure acinar cell carcinoma of the pancreas in adults. (15671372)
2005
27
Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. (15517367)
2004
28
Acinar cell carcinoma of the pancreas: clinical and computed tomography manifestations. (15091120)
2004
29
Acinar cell carcinoma of the pancreas with intraductal growth: report of a case. (12657959)
2003
30
Acinar cell carcinoma of the pancreas with and without endocrine differentiation. (18332930)
2002
31
Acinar cell carcinoma of the pancreas successfully treated by en bloc resection and intraperitoneal chemotherapy for peritoneal relapse: a case report of a 15-year survivor. (11451140)
2001
32
Pancreatic acinar cell carcinoma. (11345238)
2001
33
Acinar cell carcinoma of the pancreas showing finger-print-like zymogen granules by electron microscopy: immunohistochemical study. (10982600)
2000
34
Acinar cell carcinoma of the pancreas. (11013963)
2000
35
Immunohistochemical analysis and clinical course of high-malignant composite endocrine-acinar cell carcinoma: a case report. (9700956)
1998
36
Functioning pancreatic acinar cell carcinoma: immunohistochemical and ultrastructural analyses. (9020300)
1997
37
Fine needle aspiration cytology of acinar cell carcinoma of the pancreas: a report of two cases. (8669201)
1996
38
Resected acinar cell carcinoma of the pancreas with tumor thrombus extending into the main portal vein: report of a case. (8726623)
1996
39
Acinar cell carcinoma of the pancreas. A histologic, immunocytochemical and ultrastructural study. (8003821)
1994
40
Needle aspiration cytology of acinar-cell carcinoma of the pancreas: report of a case with diagnostic pitfalls and unusual ultrastructural findings. (7924811)
1994
41
Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. (8362971)
1993
42
Alpha-fetoprotein-producing acinar cell carcinoma of the pancreas. (1377164)
1992
43
Acinar cell carcinoma of the pancreas: a rare cause of left-sided portal hypertension. (1858743)
1991
44
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification. (3741765)
1986
45
Demonstration of kallikrein in a rat pancreatic acinar cell carcinoma. (2578095)
1985
46
Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism. (6494735)
1984
47
Acinar cell carcinoma of the rat pancreas grown in cell culture and in nude mice. (7471079)
1980
48
Transplantable acinar cell carcinoma of the rat pancreas. (426031)
1979
49
Acinar cell carcinoma of the pancreas with subcutaneous fat necrosis. (5853162)
1965
50
Functioning acinar cell carcinoma of the pancreas. (14011794)
1962

Genetic Variations for Acinar Cell Carcinoma

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Expression for genes affiliated with Acinar Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for genes affiliated with Acinar Cell Carcinoma

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Sources:
4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AFP, CTNNB1, APC
2
Hide members
9.6APC, CTNNB1, SMAD4
39.4APC, CTNNB1, AFP, SMAD4
49.4APC, CTNNB1, STK11, SMAD4
59.0MAPK6, CTNNB1, APC
68.7MAPK6, IGF2, CTNNB1, APC

Compounds for genes affiliated with Acinar Cell Carcinoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1guanine44 11 2412.4IGF2, STK11
2smcc4410.3CHGA, SYP
3methylazoxymethanol acetate4410.3APC, CTNNB1
41-hydroxyanthraquinone4410.2CTNNB1, APC
5samp4410.2APC, CTNNB1
6steroid4410.2SYP, SMAD4, AFP
71,2-dimethylhydrazine4410.1CTNNB1, APC
8111in-pentetreotide4410.1SYP, CHGA
9lithium chloride4410.1CTNNB1, CHGA
10sodium bisulfite4410.0IGF2, CTNNB1, APC
11etoposide44 49 59 1112.8AFP, IGF2, CHGA
12tgf beta1449.8SMAD4, CTNNB1, AFP, IGF2
13acth449.7APC, IGF2, SYP, CHGA
14fatty acid449.7STK11, PLA2G1B, APC, CTNNB1
15gnrh449.7CTNNB1, SMAD4, IGF2, CHGA
165-aza-2deoxycytidine449.7IGF2, CTNNB1, APC, STK11
17chloramphenicol44 2 1111.7IGF2, CHGA, AFP, SMAD4
18dexamethasone44 49 28 1112.7PLA2G1B, IGF2, AFP, CTNNB1
19lithium44 49 11 2412.7CTNNB1, SYP, APC
20hematoxylin449.6SYP, CHGA, CEACAM5
21b 723449.6CHGA, CEACAM5, SYP, AFP
22azoxymethane449.6CTNNB1, APC
23silver449.6AFP, CHGA, CEACAM5, SYP
24gold449.5AFP, SYP, CEACAM5, CHGA
255-fluorocytosine449.5CEACAM5, AFP
26vitamin d449.5CHGA, APC, AFP, CTNNB1, IGF2
27glutamine449.4IGF2, SYP, CTNNB1, AFP, APC
28p002449.4CTNNB1, IGF2, CEACAM5, CHGA
29crcs449.4CEACAM5, SMAD4, CTNNB1, APC
30phosphoserine44 2410.4REG1A, CEACAM5, APC
31irinotecan44 49 1111.3AFP, IGF2, CEACAM5
325fluorouracil449.3AFP, CEACAM5, CTNNB1, IGF2
33alanine449.2BCL10, AFP, CTNNB1, SMAD4, STK11, IGF2
34oligonucleotide449.2IGF2, SMAD4, APC, CTNNB1, AFP, CHGA
35agar449.2CTNNB1, AFP, CEACAM5, SMAD4, IGF2
36estradiol44 11 2411.1AFP, SYP, IGF2, PLA2G1B, CEACAM5
37retinoic acid44 2410.1SYP, CTNNB1, IGF2, CHGA, APC, AFP
38testosterone44 59 11 2412.0CTNNB1, IGF2, CHGA, APC, SMAD4, AFP
39cisplatin44 49 59 1112.0CEACAM5, IGF2, CHGA, SYP, AFP, CTNNB1
40lactate448.9IGF2, PLA2G1B, CEACAM5, SMAD4, AFP, CHGA
41thymidine44 249.8AFP, SMAD4, CEACAM5, IGF2, REG1A, CTNNB1
42glucose448.7APC, STK11, IGF2, REG1A, CEACAM5, SMAD4
43threonine448.6SMAD4, MAPK6, STK11, CTNNB1, APC, AFP
44vegf448.5SMAD4, IGF2, AFP, STK11, CHGA, CTNNB1
45glycogen44 249.4AFP, SYP, CTNNB1, STK11, APC, CEACAM5
46lipid448.4STK11, APC, AFP, SYP, PLA2G1B, CEACAM5
47progesterone44 59 28 11 2412.4AFP, SYP, APC, CHGA, IGF2, CTNNB1
48paraffin448.2CEACAM5, STK11, AFP, APC, SYP, CHGA
49tyrosine447.7APC, CTNNB1, AFP, CHGA, IGF2, REG1A
50serine446.9SMAD4, BCL10, RNPS1, APC, CTNNB1, STK11

GO Terms for genes affiliated with Acinar Cell Carcinoma

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16Gene Ontology
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Cellular components related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.9CTNNB1, APC

Biological processes related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:06039510.0SMAD4, AFP
2negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:0607709.9STK11, APC
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.7BCL10, CTNNB1, APC
4canonical Wnt receptor signaling pathwayGO:0600709.5CTNNB1, APC, STK11
5negative regulation of cell proliferationGO:0082859.1CTNNB1, APC, STK11, SMAD4

Molecular functions related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1R-SMAD bindingGO:0704129.9SMAD4, CTNNB1
2I-SMAD bindingGO:0704119.8CTNNB1, SMAD4
3protein complex bindingGO:0324039.4CTNNB1, STK11, SYP
4protein kinase bindingGO:0199018.8BCL10, MAPK6, CTNNB1, APC

Products for genes affiliated with Acinar Cell Carcinoma

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Sources for Acinar Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet