MCID: ACN001
MIFTS: 55

Acinar Cell Carcinoma malady

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Summaries for Acinar Cell Carcinoma

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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards based summary: Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatitis and pituitary adenoma. An important gene associated with Acinar Cell Carcinoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are LKB1 signaling events and Canonical Wnt signaling pathway. The compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:65 Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour... more...

Aliases & Classifications for Acinar Cell Carcinoma

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Acinar Cell Carcinoma, Aliases & Descriptions:

Name: Acinar Cell Carcinoma 8 10 62
Acinic Cell Carcinoma 8 42
 
Acinic Cell Tumor 42 62
Carcinoma Acinar Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3025
MeSH34 D018267
SNOMED-CT57 45410002
NCIt39 C3768

Related Diseases for Acinar Cell Carcinoma

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Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.9PLA2G1B, REG1A, SMAD4
2pituitary adenoma30.6SYP, CHGA, APC
3hypoglycemia30.5STK11, CHGA, IGF2
4pancreatic cancer30.3SMAD4, CEACAM5, STK11
5adenocarcinoma29.3SMAD4, AFP, APC, CHGA, REG1A, CEACAM5
6adenoma29.0IGF2, SMAD4, APC, CHGA, REG1A, CEACAM5
7panniculitis10.5
8extragonadal germ cell tumor10.5AFP
9sertoli cell tumor10.5SYP
10intussusception10.5STK11
11polyhydramnios10.5AFP
12neuroblastoma10.5SYP
13dysembryoplastic neuroepithelial tumor10.5SYP
14pancreatoblastoma10.4
15edwards syndrome10.4AFP, BCL10
16hemihypertrophy10.4IGF2
17central neurocytoma10.4CHGA, SYP
18pancreatic islet cell tumors10.4CHGA, SYP
19endocrine gland cancer10.4CHGA, SYP
20pineocytoma10.4CHGA, SYP
21pancreatic ductal carcinoma10.3SMAD4, CHGA
22merkel cell carcinoma10.3SYP, CHGA
23hepatitis10.3
24duodenitis10.3
25vipoma10.3SMAD4, CHGA
26hyperinsulinemic hypoglycemia10.3IGF2, CHGA
27omphalocele10.3IGF2, AFP
28ganglioglioma10.3SYP, CHGA
29pancreas disease10.3SMAD4, REG1A
30cowden disease10.3STK11, SMAD4
31choroid plexus papilloma10.3IGF2, SYP
32signet ring cell adenocarcinoma10.3CHGA, CEACAM5
33malignant mixed mullerian tumor10.3AFP, CTNNB1
34ganglioneuroma10.3CHGA, SYP
35rhabdoid tumor10.2SYP, IGF2
36microglandular adenosis10.2
37neurofibroma10.2
38endodermal sinus tumor10.2AFP, CEACAM5
39papillary carcinoma10.2SMAD4, CHGA, SYP
40embryonal rhabdomyosarcoma10.2IGF2, SMAD4
41paraganglioma10.2SYP, CHGA
42acute lymphoblastic leukemia10.2
43hepatocellular carcinoma10.2
44hypertension10.2
45islet cell tumor10.2
46leukemia10.2
47obesity10.2
48skin conditions10.2
49acute pancreatitis10.2
50pancreatic acinar cell adenocarcinoma10.2

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to acinar cell carcinoma

Symptoms for Acinar Cell Carcinoma

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Drugs & Therapeutics for Acinar Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Acinar Cell Carcinoma

Search NIH Clinical Center for Acinar Cell Carcinoma

Genetic Tests for Acinar Cell Carcinoma

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Anatomical Context for Acinar Cell Carcinoma

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MalaCards organs/tissues related to Acinar Cell Carcinoma:

32
Pancreas, Liver, Skin, Brain, Colon, Ovary

Animal Models for Acinar Cell Carcinoma or affiliated genes

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Publications for Acinar Cell Carcinoma

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Articles related to Acinar Cell Carcinoma:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Acinar cell carcinoma of the pancreas: clinical and cytomorphologic characteristics. (23667367)
2013
2
Primary acinar cell carcinoma of the liver. (23440644)
2013
3
"Chronic" metastatic pancreatic acinar cell carcinoma. (24075523)
2013
4
Acinar cell carcinoma presenting as a duodenal mass: review of the literature and a case report. (23550393)
2013
5
A case report of a patient with advanced acinar cell carcinoma of the pancreas: long-term survival with regional, systemic and targeted therapy. (23748831)
2013
6
CT imaging features of acinar cell carcinoma and its hepatic metastases. (23232580)
2013
7
Use of panitumumab in the treatment of acinar cell carcinoma of the pancreas: A case report. (23426888)
2013
8
Acinar cell carcinoma: a rare pancreatic malignancy. (24765506)
2013
9
Pancreatic panniculitis secondary to acinar cell carcinoma of the pancreas. (23763078)
2013
10
BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. (23530562)
2013
11
Endoscopic ultrasound image of alpha-fetoprotein-producing pancreatic acinar cell carcinoma. (21944950)
2012
12
Multimodal treatment of hepatic metastasis in the form of a bile duct tumor thrombus from pancreatic acinar cell carcinoma: case report of successful resection after chemoradiation therapy. (22949891)
2012
13
Image of the month: Cystic variant of pancreatic acinar cell carcinoma. (22582413)
2012
14
Pancreatic acinar cell carcinoma. (21982066)
2012
15
FOLFOX regimen in pancreatic acinar cell carcinoma: case report and review of the literature. (21961498)
2012
16
Intraductal polypoid growth variant of pancreatic acinar cell carcinoma metastasizing to the intrahepatic bile duct 6 years after surgery: a case report and literature review. (22487469)
2012
17
Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3). (22687839)
2012
18
Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature. (19584100)
2011
19
Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. (21893434)
2011
20
Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis. (21546712)
2011
21
Image of the month. Acinar cell carcinoma. (21931007)
2011
22
Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. (21572398)
2011
23
Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. (20534994)
2010
24
A case of pancreatic acinar cell carcinoma metastatic to skin. (21234254)
2010
25
Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst. (20090274)
2010
26
Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa. (19144387)
2009
27
Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy. (19239719)
2009
28
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. (18724247)
2008
29
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
30
Long-term survival in a patient with acinar cell carcinoma of pancreas. A case report and review of literature. (17993731)
2007
31
A long-term survivor of metastatic acinar cell carcinoma. (17312470)
2007
32
Pancreatic acinar cell carcinoma with intracranial metastasis in a dog. (17283409)
2007
33
Acinar cell carcinoma of the pancreas in a young patient with cells immunoreactive for somatostatin. (16430479)
2006
34
Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts. (16984622)
2006
35
Intraductal acinar cell carcinoma of the pancreas. (11315630)
2001
36
Acinar cell carcinoma of the pancreas successfully treated by en bloc resection and intraperitoneal chemotherapy for peritoneal relapse: a case report of a 15-year survivor. (11451140)
2001
37
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. (10982618)
2000
38
Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II. (9773947)
1998
39
Functioning pancreatic acinar cell carcinoma: immunohistochemical and ultrastructural analyses. (9020300)
1997
40
Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. (9067100)
1997
41
Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation. (7541276)
1995
42
Acinar cell carcinoma of the pancreas: a rare cause of left-sided portal hypertension. (1858743)
1991
43
Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. (3542187)
1987
44
Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. (3940400)
1986
45
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification. (3741765)
1986
46
Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism. (6494735)
1984
47
Acinar cell carcinoma of the pancreas in a cat. (473484)
1979
48
Pancreatic acinar cell carcinoma in childhood. (4834991)
1974
49
Acinar cell carcinoma of the pancreas with subcutaneous fat necrosis. (5853162)
1965
50
Functioning acinar cell carcinoma of the pancreas. (14011794)
1962

Variations for Acinar Cell Carcinoma

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Expression for genes affiliated with Acinar Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for genes affiliated with Acinar Cell Carcinoma

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Pathways related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8STK11, SMAD4
29.7CTNNB1, APC
39.5SMAD4, STK11, CTNNB1
49.5CTNNB1, STK11, SMAD4
59.4CTNNB1, APC, AFP
6
Show member pathways
Wnt Signaling Pathway NetPath37
9.3SMAD4, APC, CTNNB1
79.3CTNNB1, APC, SMAD4
8
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.3CTNNB1, APC, SMAD4
9
Show member pathways
Signal transduction PTEN pathway60
9.3CTNNB1, APC, SMAD4
109.2IGF2, APC, CTNNB1
119.1CTNNB1, APC, AFP, SMAD4
129.0CTNNB1, STK11, APC, SMAD4

Compounds for genes affiliated with Acinar Cell Carcinoma

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Compounds related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4410.0CTNNB1, APC
21-hydroxyanthraquinone4410.0APC, CTNNB1
3samp449.9APC, CTNNB1
4smcc449.9SYP, CHGA
5sodium bisulfite449.6IGF2, CTNNB1, APC
61,2-dimethylhydrazine449.6APC, CTNNB1
7b 723449.5AFP, SYP, CEACAM5, CHGA
8hematoxylin449.5CHGA, SYP, CEACAM5
9silver449.5SYP, CEACAM5, AFP, CHGA
10gold449.4SYP, CEACAM5, AFP, CHGA
11chloramphenicol44 2 50 1112.4CHGA, AFP, SMAD4, IGF2
12tgf beta1449.4CTNNB1, IGF2, AFP, SMAD4
13etoposide44 50 61 1112.3IGF2, SYP, CHGA, AFP
14gnrh449.3SMAD4, IGF2, CHGA, CTNNB1
15acth449.3APC, IGF2, SYP, CHGA
165-aza-2deoxycytidine449.2CTNNB1, STK11, APC, IGF2
17crcs449.2CTNNB1, CEACAM5, SMAD4, APC
18p002449.2CHGA, CTNNB1, CEACAM5, IGF2
19phosphoserine44 2410.2REG1A, APC, CEACAM5
20paclitaxel44 50 1111.2CHGA, CTNNB1, IGF2, AFP
215fluorouracil449.1AFP, IGF2, CTNNB1, CEACAM5
22vitamin d449.1IGF2, APC, AFP, CTNNB1, CHGA
23lithium44 50 24 1112.1APC, SYP, CTNNB1
24norepinephrine44 24 1111.0IGF2, APC, CHGA, SYP
25butyrate449.0CTNNB1, IGF2, AFP, CEACAM5
26glutamine449.0CTNNB1, AFP, APC, SYP, IGF2
27agar448.9IGF2, SMAD4, AFP, CEACAM5, CTNNB1
28alanine448.8IGF2, CTNNB1, STK11, BCL10, AFP, SMAD4
29guanine44 24 1110.8IGF2, SYP, STK11, CTNNB1, CHGA, APC
30oligonucleotide448.7SMAD4, CHGA, APC, AFP, IGF2, CTNNB1
31retinoic acid44 249.7CTNNB1, SYP, CHGA, APC, IGF2, AFP
32cisplatin44 50 61 1111.7AFP, CHGA, CEACAM5, SYP, CTNNB1, IGF2
33h2o2448.5IGF2, AFP, CTNNB1, PLA2G1B, SYP
34testosterone44 61 24 1111.4CHGA, IGF2, SMAD4, AFP, APC, CTNNB1
35estradiol44 24 1110.4SYP, CEACAM5, AFP, IGF2, PLA2G1B
36fatty acid448.4AFP, STK11, APC, PLA2G1B, CTNNB1, CHGA
37thymidine44 249.4AFP, IGF2, SMAD4, REG1A, CEACAM5, CTNNB1
38steroid448.3CTNNB1, SYP, CEACAM5, CHGA, SMAD4, IGF2
39dexamethasone44 50 28 1111.3CHGA, SYP, IGF2, CTNNB1, AFP, PLA2G1B
40lactate448.2IGF2, SMAD4, AFP, CHGA, CEACAM5, PLA2G1B
41vegf448.0CTNNB1, CHGA, SMAD4, STK11, AFP, IGF2
42glycogen44 249.0AFP, IGF2, SYP, STK11, CEACAM5, CHGA
43estrogen447.9IGF2, SYP, CEACAM5, AFP, APC, SMAD4
44glucose447.8IGF2, SMAD4, AFP, APC, REG1A, STK11
45lipid447.7BCL10, SYP, PLA2G1B, STK11, CEACAM5, APC
46paraffin447.6CTNNB1, CEACAM5, CHGA, APC, STK11, AFP
47progesterone44 28 61 24 1111.5IGF2, CTNNB1, SYP, PLA2G1B, CHGA, CEACAM5
48calcium44 50 24 1110.4CHGA, APC, CEACAM5, SYP, STK11, AFP
49serine446.8CTNNB1, IGF2, AFP, SYP, STK11, REG1A
50tyrosine446.6AFP, SYP, CTNNB1, CEACAM5, REG1A, CHGA

GO Terms for genes affiliated with Acinar Cell Carcinoma

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Cellular components related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.7CTNNB1, APC
2lateral plasma membraneGO:0163289.7CTNNB1, APC
3cell-cell adherens junctionGO:0059139.6CTNNB1, APC
4cytosolGO:0058297.9SMAD4, APC, RNPS1, STK11, BCL10, CTNNB1

Biological processes related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:06039510.0SMAD4, AFP
2negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.0STK11, APC
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.9STK11, SMAD4
4canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:0443369.9CTNNB1, APC
5gastrulation with mouth forming secondGO:0017029.8CTNNB1, SMAD4
6proximal/distal pattern formationGO:0099549.7CTNNB1, APC
7thymus developmentGO:0485389.7CTNNB1, APC
8cellular response to mechanical stimulusGO:0712609.6CTNNB1, BCL10, IGF2
9canonical Wnt signaling pathwayGO:0600709.6APC, STK11, CTNNB1
10T cell differentiation in thymusGO:0330779.6APC, CTNNB1
11negative regulation of cell proliferationGO:0082859.2CTNNB1, STK11, APC, SMAD4
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.2CTNNB1, PLA2G1B, SMAD4, IGF2

Molecular functions related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:0704119.8CTNNB1, SMAD4
2cadherin bindingGO:0452969.7CTNNB1, APC
3R-SMAD bindingGO:0704129.7CTNNB1, SMAD4
4protein complex bindingGO:0324039.2CTNNB1, SYP, STK11

Products for genes affiliated with Acinar Cell Carcinoma

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Sources for Acinar Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet