MCID: ACN001
MIFTS: 51

Acinar Cell Carcinoma malady

Cancer diseases category

Summaries for Acinar Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards: Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatitis and adenocarcinoma. An important gene associated with Acinar Cell Carcinoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are Wnt / Hedgehog / Notch and Endometrial cancer. The compounds guanine and smcc have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour... more...

Aliases & Classifications for Acinar Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

acinar cell carcinoma 8 10 60
acinic cell carcinoma 8 42
carcinoma acinar cell 44
acinic cell tumor 42


External Ids:

Disease Ontology8 DOID:3025
NCIt39 C3768
SNOMED-CT56 45410002
MeSH34 D018267

Related Diseases for Acinar Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.5SMAD4, PLA2G1B, REG1A
2adenocarcinoma30.6APC, CTNNB1, STK11, AFP, SYP, CHGA
3pituitary adenoma30.5APC, SYP, CHGA
4adenoma30.4APC, CTNNB1, STK11, SMAD4, CEACAM5, REG1A
5hepatitis30.4AFP
6large cell carcinoma30.4SYP, CHGA, CEACAM5
7neuroendocrine carcinoma30.4CEACAM5, CHGA, SYP
8neuroendocrine tumor30.2CHGA
9pancreas disease30.2REG1A, SMAD4
10pancreatic ductal carcinoma30.2CHGA, SMAD4
11leukemia30.2BCL10
12papillary carcinoma30.1SMAD4, CHGA, SYP
13pancreatic cancer30.1CTNNB1, STK11, CHGA, REG1A, CEACAM5, SMAD4
14hepatocellular carcinoma30.1APC, CTNNB1, STK11, AFP, IGF2, REG1A
15panniculitis10.5
16pancreas adenocarcinoma10.4
17acinic cell breast carcinoma10.4
18pancreatic acinar cell adenocarcinoma10.4
19pancreatoblastoma10.4
20bile duct carcinoma10.4
21acute pancreatitis10.3
22pancreatic endocrine carcinoma10.3
23duodenitis10.3
24microglandular adenosis of breast10.2
25basal cell carcinoma10.2
26microglandular adenosis10.2
27neurofibroma10.2
28ductal carcinoma in situ10.1
29cushing's syndrome10.1
30pleomorphic carcinoma10.1
31portal hypertension10.1
32hypoglycemia10.1
33adenocarcinoma in situ10.1
34acute leukemia10.1
35hepatitis a10.1
36childhood leukemia10.1
37hypertension10.1
38in situ carcinoma10.1
39islet cell tumor10.1
40lymphoblastic leukemia10.1
41myeloma10.1
42obesity10.1
43peritonitis10.1
44pulmonary neuroendocrine tumor10.1
45parathyroid adenoma10.0CHGA
46sertoli cell tumor10.0SYP
47multiple endocrine neoplasia10.0CHGA
48extragonadal germ cell tumor10.0AFP
49diabetes mellitus10.0REG1A
50phaeochromocytoma10.0CHGA

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to acinar cell carcinoma

Clinical Features for Acinar Cell Carcinoma

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Drugs & Therapeutics for Acinar Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acinar Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Acinar Cell Carcinoma

Search NIH Clinical Center for Acinar Cell Carcinoma

Search CenterWatch for Acinar Cell Carcinoma

Genetic Tests for Acinar Cell Carcinoma

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Anatomical Context for Acinar Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Acinar Cell Carcinoma:

32
Pancreas, Liver, Skin, Brain, Colon, Ovary

Animal Models for Acinar Cell Carcinoma or affiliated genes

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36MGI
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Publications for Acinar Cell Carcinoma

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50PubMed
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Articles related to Acinar Cell Carcinoma:

(show top 50)    (show all 179)
idTitleAuthorsYear
1
CT imaging features of acinar cell carcinoma and its hepatic metastases. (23232580)
2013
2
Pancreatic panniculitis secondary to acinar cell carcinoma of the pancreas. (23763078)
2013
3
BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. (23530562)
2013
4
Clinical and CT imaging features of pancreatic acinar cell carcinoma. (23358813)
2013
5
Intraductal growing acinar cell carcinoma of the pancreas. (23515859)
2013
6
Computed tomography features of acinar cell carcinoma of the pancreas. (22961504)
2013
7
Multimodal treatment of hepatic metastasis in the form of a bile duct tumor thrombus from pancreatic acinar cell carcinoma: case report of successful resection after chemoradiation therapy. (22949891)
2012
8
Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3). (22687839)
2012
9
Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. (21893434)
2011
10
Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis. (21546712)
2011
11
Acinar cell carcinoma of the pancreas: a rare tumor with a particular clinical and paraclinical presentation. (21316330)
2011
12
An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development. (21475719)
2011
13
Expression of claudin-5 in canine pancreatic acinar cell carcinoma - An immunohistochemical study. (21354944)
2011
14
Acinar cell carcinoma of the pancreas: a case report and review of the literature. (22191136)
2011
15
Pancreatic-type acinar cell carcinoma of the liver: a clinicopathologic study of four patients. (21841771)
2011
16
PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. (20890270)
2011
17
CT and MRI features of acinar cell carcinoma of the pancreas with pathological correlations. (20152279)
2010
18
A pancreatic mass presented with multiple hot spots in the subcutaneous fat layer on positron emission tomography. Acinar cell carcinoma with multiple fat necrosis. (20800656)
2010
19
The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. (19066953)
2009
20
Spontaneous rupture of the splenic metastasis in acinar cell carcinoma. (19893460)
2009
21
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. (18724247)
2008
22
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
23
Acinar cell carcinoma--a rare tumour of the pancreas. (18807305)
2008
24
Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature. (17957440)
2008
25
Pancreatic acinar cell carcinoma with intracranial metastasis in a dog. (17283409)
2007
26
Acinar cell carcinoma arising from an ectopic pancreas. (17643220)
2007
27
Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts. (16984622)
2006
28
Radiology-pathology conference. Acinar cell carcinoma of the pancreas. (16919557)
2006
29
Cytology of pancreatic acinar cell carcinoma. (16604543)
2006
30
Recurrent pancreatitis due to a cystic pancreatic tumor: a rare presentation of acinar cell carcinoma. (15138338)
2004
31
Acinar cell carcinoma of the pancreas. (15361637)
2003
32
Acinar cell carcinoma of the pancreas in a morbidly obese patient. (12409840)
2002
33
Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. (12488412)
2002
34
Acinar cell carcinoma of the pancreas. (11473479)
2001
35
Acinar cell carcinoma with hypervascularity. (11206307)
2001
36
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. (10982618)
2000
37
Appearance of acinar cell carcinoma of the pancreas on dual-phase CT. (9843323)
1998
38
Derivation of ductlike cell lines from a transplantable acinar cell carcinoma of the rat pancreas. (8391218)
1993
39
Expression of alveolar type II cell markers in acinar adenocarcinomas and adenoid cystic carcinomas arising from segmental bronchi. A study in a heterotopic bronchogenic carcinoma model in dogs. (8386445)
1993
40
Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. (1384374)
1992
41
Acinar cell carcinoma of the pancreas. Report of two cases with complex histomorphologic features causing diagnostic problems. (1289423)
1992
42
Acinar cell carcinoma of the pancreas with elevated serum alpha-fetoprotein levels: a case report and a review of 28 cases reported in Japan. (1281798)
1992
43
Calcified brain metastases from acinar-cell carcinoma of pancreas. (2747904)
1989
44
Myeloma-like cast nephropathy associated with acinar cell carcinoma of the pancreas. (3239601)
1988
45
Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. (3940400)
1986
46
Lipid composition and 3-hydroxy-3-methylglutaryl-CoA reductase activity of acinar cell carcinoma of rat pancreas. (6882793)
1983
47
Acinar cell carcinoma of the pancreas in a cat. (473484)
1979
48
Acinar cell carcinoma of the pancreas in a 9-year-old child: case report with electron microscopic observations. (847494)
1977
49
Pancreatic acinar cell carcinoma in childhood. (4834991)
1974
50
Syndrome associated with pancreatic acinar cell carcinoma. (5429656)
1970

Genetic Variations for Acinar Cell Carcinoma

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Expression for genes affiliated with Acinar Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for genes affiliated with Acinar Cell Carcinoma

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4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AFP, CTNNB1, APC
2
Hide members
9.6APC, CTNNB1, SMAD4
39.4APC, CTNNB1, AFP, SMAD4
49.4APC, CTNNB1, STK11, SMAD4
59.0MAPK6, CTNNB1, APC
68.7MAPK6, IGF2, CTNNB1, APC

Compounds for genes affiliated with Acinar Cell Carcinoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1guanine44 11 2412.4IGF2, STK11
2smcc4410.3CHGA, SYP
3methylazoxymethanol acetate4410.3APC, CTNNB1
41-hydroxyanthraquinone4410.2CTNNB1, APC
5samp4410.2APC, CTNNB1
6steroid4410.2SYP, SMAD4, AFP
71,2-dimethylhydrazine4410.1CTNNB1, APC
8111in-pentetreotide4410.1SYP, CHGA
9lithium chloride4410.1CTNNB1, CHGA
10sodium bisulfite4410.0IGF2, CTNNB1, APC
11etoposide44 49 59 1112.8AFP, IGF2, CHGA
12tgf beta1449.8SMAD4, CTNNB1, AFP, IGF2
13acth449.7APC, IGF2, SYP, CHGA
14fatty acid449.7STK11, PLA2G1B, APC, CTNNB1
15gnrh449.7CTNNB1, SMAD4, IGF2, CHGA
165-aza-2deoxycytidine449.7IGF2, CTNNB1, APC, STK11
17chloramphenicol44 2 1111.7IGF2, CHGA, AFP, SMAD4
18dexamethasone44 49 28 1112.7PLA2G1B, IGF2, AFP, CTNNB1
19lithium44 49 11 2412.7CTNNB1, SYP, APC
20hematoxylin449.6SYP, CHGA, CEACAM5
21b 723449.6CHGA, CEACAM5, SYP, AFP
22azoxymethane449.6CTNNB1, APC
23silver449.6AFP, CHGA, CEACAM5, SYP
24gold449.5AFP, SYP, CEACAM5, CHGA
255-fluorocytosine449.5CEACAM5, AFP
26vitamin d449.5CHGA, APC, AFP, CTNNB1, IGF2
27glutamine449.4IGF2, SYP, CTNNB1, AFP, APC
28p002449.4CTNNB1, IGF2, CEACAM5, CHGA
29crcs449.4CEACAM5, SMAD4, CTNNB1, APC
30phosphoserine44 2410.4REG1A, CEACAM5, APC
31irinotecan44 49 1111.3AFP, IGF2, CEACAM5
325fluorouracil449.3AFP, CEACAM5, CTNNB1, IGF2
33alanine449.2BCL10, AFP, CTNNB1, SMAD4, STK11, IGF2
34oligonucleotide449.2IGF2, SMAD4, APC, CTNNB1, AFP, CHGA
35agar449.2CTNNB1, AFP, CEACAM5, SMAD4, IGF2
36estradiol44 11 2411.1AFP, SYP, IGF2, PLA2G1B, CEACAM5
37retinoic acid44 2410.1SYP, CTNNB1, IGF2, CHGA, APC, AFP
38testosterone44 59 11 2412.0CTNNB1, IGF2, CHGA, APC, SMAD4, AFP
39cisplatin44 49 59 1112.0CEACAM5, IGF2, CHGA, SYP, AFP, CTNNB1
40lactate448.9IGF2, PLA2G1B, CEACAM5, SMAD4, AFP, CHGA
41thymidine44 249.8AFP, SMAD4, CEACAM5, IGF2, REG1A, CTNNB1
42glucose448.7APC, STK11, IGF2, REG1A, CEACAM5, SMAD4
43threonine448.6SMAD4, MAPK6, STK11, CTNNB1, APC, AFP
44vegf448.5SMAD4, IGF2, AFP, STK11, CHGA, CTNNB1
45glycogen44 249.4AFP, SYP, CTNNB1, STK11, APC, CEACAM5
46lipid448.4STK11, APC, AFP, SYP, PLA2G1B, CEACAM5
47progesterone44 59 28 11 2412.4AFP, SYP, APC, CHGA, IGF2, CTNNB1
48paraffin448.2CEACAM5, STK11, AFP, APC, SYP, CHGA
49tyrosine447.7APC, CTNNB1, AFP, CHGA, IGF2, REG1A
50serine446.9SMAD4, BCL10, RNPS1, APC, CTNNB1, STK11

GO Terms for genes affiliated with Acinar Cell Carcinoma

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16Gene Ontology
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Cellular components related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.9CTNNB1, APC

Biological processes related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:06039510.0SMAD4, AFP
2negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:0607709.9STK11, APC
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.7BCL10, CTNNB1, APC
4canonical Wnt receptor signaling pathwayGO:0600709.5APC, CTNNB1, STK11
5negative regulation of cell proliferationGO:0082859.1SMAD4, STK11, CTNNB1, APC

Molecular functions related to Acinar Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1R-SMAD bindingGO:0704129.9SMAD4, CTNNB1
2I-SMAD bindingGO:0704119.8CTNNB1, SMAD4
3protein complex bindingGO:0324039.4SYP, STK11, CTNNB1
4protein kinase bindingGO:0199018.8BCL10, MAPK6, CTNNB1, APC

Products for genes affiliated with Acinar Cell Carcinoma

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Sources for Acinar Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet