ACNE
MCID: ACN011
MIFTS: 56

Acne (ACNE) malady

Skin diseases category

Summaries for Acne

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Acne, also known as acne, unspecified, is related to hidradenitis suppurativa and arthritis. An important gene associated with Acne is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. The compounds dexamethasone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and bone.

Wikipedia:63 Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of skin with... more...

Description from OMIM:46 604324

Aliases & Classifications for Acne

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

acne 8 10 33 30 60
acne, unspecified 8


External Ids:

Disease Ontology8 DOID:6543
OMIM46 604324
NCIt39 C27195
ICD1025 L70, L70.9

Related Diseases for Acne

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acne via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa30.9PSENEN, NCSTN
2arthritis30.5IL1A, PSTPIP1, TLR2, PPARA
3psoriasis30.5IL1A, TLR2, PPARA, DEFB4A
4alopecia30.4BTD, SHBG
5skin disease30.3DEFB4A, PPARA, TLR2, IL1A, SRD5A1
6polycystic ovary syndrome30.3SHBG, CYP21A2, SRD5A1, PPARA
7hyperandrogenism30.3SRD5A1, CYP21A2, SHBG
8sarcoidosis30.3IL1A, DEFB4A, DEFB1
9dermatitis30.3IL1A, BTD, PPARA
10androgenic alopecia30.0SHBG, CYP21A2, SRD5A1
11atopic dermatitis30.0DEFB4A, TLR2
12inflammatory bowel disease30.0TLR2
13congenital adrenal hyperplasia29.9CYP21A2, BTD, SRD5A1
14ulcerative colitis29.9DEFB4A, DEFB1, IL1A, TLR2
15periodontitis29.7IL1A, DEFB4A, DEFB1, TLR2
16candidiasis29.7DEFB4A, BTD
17peritonitis29.7TLR2
18klinefelter's syndrome29.7SRD5A1, CYP21A2, SHBG
19rosacea10.7
20hidradenitis10.6
21synovitis10.6
22hyperostosis10.6
23sapho syndrome10.6
24pyoderma10.4
25pyoderma gangrenosum10.4
26osteomyelitis10.4
27folliculitis10.3
28pyogenic arthritis, pyoderma gangrenosum and acne10.3
29acne inversa, familial, 110.2
30frontalis acne10.2
31pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
32pseudotumor cerebri10.1
33cellulitis10.1
34endophthalmitis10.1
35acne inversa, familial, 310.1
36acne inversa, familial, 210.1
3721-hydroxylase deficiency10.1
38keratosis follicularis10.0
39subdural empyema10.0
40psoriatic arthritis10.0
41pityriasis rubra pilaris10.0
42keratosis10.0
43spondyloarthropathy10.0
44squamous cell carcinoma10.0
45uveitis10.0
46dowling-degos disease10.0
47retinol dystrophy, iris coloboma, and comedogenic acne syndrome10.0
48alzheimer's disease10.0PPARA, IL1A, SHBG, NCSTN, PSENEN, PSEN1
49cystic fibrosis10.0DEFB1, BTD, NF2, DEFB4A
50periodontal disease10.0DEFB4A, IL1A, DEFB1, TLR2

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Clinical Features for Acne

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

604324

Drugs & Therapeutics for Acne

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Acne

Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Search CenterWatch for Acne

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

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Anatomical Context for Acne

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acne:

32
Skin, Ovary, Bone, Brain, Monocytes, Testes, Salivary gland, Lung, Liver, Colon, T cells

Animal Models for Acne or affiliated genes

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Publications for Acne

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Sources:
50PubMed
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Articles related to Acne:

(show top 50)    (show all 896)
idTitleAuthorsYear
1
Acne in Pregnant Women: A French Survey. (23824172)
2014
2
Childhood acne in a boy with XYY syndrome. (24395875)
2014
3
Successful treatment in a case of Propionibacterium acnes-associated sarcoidosis with clarithromycin administration: a case report. (24428939)
2014
4
Randomized, controlled, evaluator-blinded studies conducted to compare the efficacy and tolerability of 3 over-the-counter acne regimens in subjects with mild or moderate acne. (23377391)
2013
5
Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. (23096708)
2013
6
The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne. (23653117)
2013
7
Most common patterns of acne in male adolescents: a population-based study. (23590370)
2013
8
Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. (24011352)
2013
9
Sensitivity and specificity of self-reported acne in 18-year-old adolescent males. (23786338)
2013
10
Salicylic acid peels versus Jessner's solution for acne vulgaris: a comparative study. (23121256)
2013
11
Evaluating of life quality in patients with acne vulgaris using generic and specific questionnaires. (24371434)
2013
12
Correlation of photographic images from the Leeds revised acne grading system with a six-category global acne severity scale. (22924863)
2013
13
Auto-classification of acne lesions using multimodal imaging. (23884485)
2013
14
The Cardiff Acne Disability Index (CADI): linguistic and cultural validation in Serbian. (22362521)
2013
15
Male acne: the importance of gender in acne treatment. (23763071)
2013
16
Comparison of the efficacies of intermittent and continuous low-dose isotretinoin regimens in the treatment of moderate acne vulgaris. (23675954)
2013
17
European Commission orders France to lift ban on acne pill. (23918671)
2013
18
A brief primer on acne therapy for adolescents with skin of color. (23961520)
2013
19
The management of acne vulgaris in pregnancy. (23996075)
2013
20
Long-term use of tetracycline and Staphylococcus aureus tetracycline resistance: not only a problem of acne. (22431791)
2012
21
Re. Inflammation in rosacea and acne: implications for patient care. (22303551)
2012
22
High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study. (22898209)
2012
23
Histological validity and clinical evidence for use of fractional lasers for acne scars. (23060702)
2012
24
Increased prevalence of metabolic syndrome in patients with acne inversa. (22359634)
2012
25
Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. (22517509)
2012
26
Native American skin offerings mistaken for acne scars in a college undergraduate. (23069975)
2012
27
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome: is PTPN22 involved? (22513164)
2012
28
Modulation of cytokine and nitric oxide production by keratinocytes, epithelial cells, and mononuclear phagocytes in a co-culture model of inflammatory acne. (22777225)
2012
29
Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study. (22399861)
2012
30
Generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris. (22470202)
2012
31
Tretinoin microsphere gel 0.04% pump for treating acne vulgaris in preadolescents: a randomized, controlled study. (22712470)
2012
32
High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life. (22909370)
2012
33
Human beta-defensin-2 and psoriasin are overexpressed in lesions of acne inversa. (19249126)
2009
34
Rosacea/acne rosacea: efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment. (18435734)
2008
35
Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblasts. (18049448)
2008
36
CBT-SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin-8 induced by Propionibacterium acnes in cultured human keratinocytes. (18667861)
2008
37
Antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists. (18924545)
2008
38
Common NOD2 mutations are rare in patients with inverse acne. (18640012)
2008
39
Acne keloidalis: a novel presentation for tinea capitis. (17141363)
2007
40
An adolescent girl with tuberous sclerosis complex and acne. (16783975)
2006
41
Hidradenitis should not be renamed acne inversa. (17459292)
2006
42
Pediatric ocular acne rosacea: long-term treatment with systemic antibiotics. (17056363)
2006
43
Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects. (16781309)
2006
44
Lithium induced hidradenitis suppurativa and acne conglobata. (17642646)
2004
45
Advances in the topical treatment of acne and rosacea. (15552595)
2004
46
Propionibacterium acnes causing delayed subdural empyema - a case report and review of literature. (15261253)
2004
47
The association of serum androsterone glucuronide with inflammatory lesions in women with adult acne. (12398233)
2002
48
Sebaceous glands in acne patients express high levels of neutral endopeptidase. (12102663)
2002
49
Clinical and hormonal effects of ethinylestradiol combined with gestodene and desogestrel in young women with acne vulgaris. (8689881)
1996
50
Experience in the long-term treatment of patients with hirsutism and/or acne with cyproterone acetate-containing preparations: efficacy, metabolic and endocrine effects. (7584530)
1995

Genetic Variations for Acne

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Expression for genes affiliated with Acne

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acne

Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems, 59Tocris Bioscience
See all sources

Pathways related to Acne according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL1A, PSEN1, PSENEN, PPARA, MT-ND4, MT-ND3
2
Hide members
10.8CYP21A2, BTD, MT-ATP8, MT-ND4L, MT-ND3, MT-ND4
3
Hide members
10.7PSEN1, PSENEN, PPARA, NCSTN, IL1A
410.7NF2, NCSTN, PSENEN, PSEN1
5
Hide members
10.7IL1A, NCSTN, PSEN1, TLR2
6
Hide members
10.6PSEN1, PSENEN, NCSTN
710.6PSEN1, PSENEN, NCSTN
810.6PSEN1, PSENEN, NCSTN
910.6PSEN1, PSENEN, NCSTN
1010.6PSEN1, PSENEN, NCSTN
11
Hide members
10.6NCSTN, PSENEN, PSEN1
1210.6NCSTN, PSENEN, PSEN1
1310.6NCSTN, PSENEN, PSEN1
14
Hide members
10.6DEFB4A, DEFB1, TLR2
15
Immune response Bacterial infections in normal airways
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10.6TLR2, DEFB4A, IL1A
16
Hide members
10.6NCSTN, PSENEN
1710.6PSENEN, PSEN1

Compounds for genes affiliated with Acne

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acne according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.3DEFB1, CYP21A2, SRD5A1, IL1A, SHBG, DEFB4A
2retinoic acid44 2412.3PSEN1, PPARA, DEFB4A, SHBG, IL1A, SRD5A1
3lipid4411.3CYP21A2, SHBG, NCSTN, DEFB4A, PPARA, PSENEN
4serine4411.3MT-ND3, TLR2, PSEN1, PSTPIP1, PPARA, NF2
5cholesterol44 28 11 2414.2TLR2, SHBG, PSEN1, PSENEN, NCSTN, CYP21A2
6arginine4411.2IL1A, PPARA, TLR2, SHBG, BTD, CYP21A2
7genistein44 28 59 2 11 2416.2SRD5A1, DEFB4A, IL1A, CYP21A2, PPARA, SHBG
8progesterone44 59 28 11 2415.2CYP21A2, NF2, SHBG, IL1A, SRD5A1, DEFB4A
9calcitriol44 59 11 2414.1IL1A, SHBG, SRD5A1, PPARA, TLR2
10vitamin d4411.1SRD5A1, TLR2, PPARA, SHBG, IL1A
11norepinephrine44 11 2413.1IL1A, PSEN1, PPARA, CYP21A2, SHBG
12ketoconazole44 28 11 2414.1SRD5A1, IL1A, CYP21A2, SHBG
13glucose4411.1DEFB1, BTD, PSEN1, CYP21A2
14biotin44 11 2413.1PSEN1, SHBG, CYP21A2, BTD
15hbd24411.1DEFB4A, TLR2, DEFB1
16alanine4411.0PSEN1, SHBG, MT-ND3, BTD, TLR2, PPARA
173-alpha-androstanediol glucuronide44 2412.0CYP21A2, SRD5A1, SHBG
1817-hydroxyprogesterone44 2412.0SHBG, SRD5A1, CYP21A2
19isotretinoin44 1112.0SRD5A1, BTD, PPARA
20simvastatin44 49 59 28 11 2416.0TLR2, IL1A, SHBG, PPARA
21polymyxin b4411.0IL1A, DEFB1, TLR2
22spironolactone49 44 59 28 1115.0SRD5A1, CYP21A2, SHBG
23valine4411.0PPARA, CYP21A2, MT-ND4, PSEN1
24mrk 5605911.0PSENEN, PSEN1
25jlk 65911.0PSEN1, PSENEN
26begacestat5911.0PSEN1, PSENEN
27cycloheximide4411.0PPARA, IL1A, PSEN1, TLR2, CYP21A2
28l-685,4585911.0PSENEN, PSEN1
29dapt5910.9PSENEN, PSEN1
30rantes4410.9DEFB1, TLR2, DEFB4A, IL1A
31dehydroepiandrosterone sulfate4410.9SHBG, SRD5A1, CYP21A2
32epitestosterone4410.9SRD5A1, SHBG
33phenytoin44 49 28 1113.9CYP21A2, SRD5A1, SHBG
34formestane4410.9SRD5A1, SHBG
35enterolactone4410.9SHBG, SRD5A1
36ment4410.9SHBG, SRD5A1
37dhea4410.9SRD5A1, CYP21A2, SHBG
38norgestimate44 1111.9SRD5A1, SHBG
39androstenediol4410.9SHBG, SRD5A1
40androstenedione44 2411.8CYP21A2, SRD5A1, SHBG
41nadh44 11 2412.8MT-ND4L, MT-ND3, MT-ATP8, MT-ND4
4217-hydroxypregnenolone4410.8CYP21A2, SHBG
43desogestrel44 1111.8SHBG, SRD5A1
44acarbose44 1111.7PPARA, SHBG
45goserelin44 28 1112.7SHBG, SRD5A1
4611 deoxycortisol4410.6CYP21A2, SHBG
47testosterone44 59 11 2413.6SRD5A1, CYP21A2, SHBG, IL1A, PPARA
48allopregnanolone4410.6SRD5A1, SHBG
49doca4410.6SRD5A1, CYP21A2
50trichloroethylene4410.3SHBG, PPARA

GO Terms for genes affiliated with Acne

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Sources:
16Gene Ontology
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Biological processes related to Acne according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:04298710.9NCSTN, PSENEN, PSEN1
2Notch receptor processingGO:00722010.8NCSTN, PSENEN, PSEN1
3membrane protein ectodomain proteolysisGO:00650910.8PSEN1, PSENEN, NCSTN
4protein processingGO:01648510.8NCSTN, PSENEN, PSEN1
5positive regulation of catalytic activityGO:04308510.8NCSTN, PSENEN, PSEN1
6beta-amyloid metabolic processGO:05043510.7PSEN1, NCSTN
7positive regulation of apoptotic processGO:04306510.7ACIN1, NCSTN, PSENEN, PSEN1
8epithelial cell proliferationGO:05067310.6NCSTN, PSEN1
9Notch signaling pathwayGO:00721910.6NCSTN, PSENEN, PSEN1
10membrane protein intracellular domain proteolysisGO:03129310.5PSENEN, NCSTN
11immune responseGO:00695510.4IL1A, DEFB4A, DEFB1, TLR2

Products for genes affiliated with Acne

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acne

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet