ACNE
MCID: ACN011
MIFTS: 56

Acne (ACNE) malady

Skin diseases category

Summaries for Acne

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Acne, also known as acne, unspecified, is related to hidradenitis suppurativa and arthritis. An important gene associated with Acne is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. The compounds dexamethasone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and bone.

Wikipedia:63 Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of skin with... more...

Description from OMIM:46 604324

Aliases & Classifications for Acne

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

acne 8 10 33 30 60
acne, unspecified 8


External Ids:

Disease Ontology8 DOID:6543
OMIM46 604324
NCIt39 C27195
ICD1025 L70, L70.9

Related Diseases for Acne

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acne via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa30.9PSENEN, NCSTN
2arthritis30.5IL1A, PSTPIP1, TLR2, PPARA
3psoriasis30.5IL1A, TLR2, PPARA, DEFB4A
4alopecia30.4BTD, SHBG
5skin disease30.3DEFB4A, PPARA, TLR2, IL1A, SRD5A1
6polycystic ovary syndrome30.3SHBG, CYP21A2, SRD5A1, PPARA
7hyperandrogenism30.3SRD5A1, CYP21A2, SHBG
8sarcoidosis30.3IL1A, DEFB4A, DEFB1
9dermatitis30.3IL1A, BTD, PPARA
10androgenic alopecia30.0SHBG, CYP21A2, SRD5A1
11atopic dermatitis30.0DEFB4A, TLR2
12inflammatory bowel disease30.0TLR2
13congenital adrenal hyperplasia29.9CYP21A2, BTD, SRD5A1
14ulcerative colitis29.9DEFB4A, DEFB1, IL1A, TLR2
15periodontitis29.7IL1A, DEFB4A, DEFB1, TLR2
16candidiasis29.7DEFB4A, BTD
17peritonitis29.7TLR2
18klinefelter's syndrome29.7SRD5A1, CYP21A2, SHBG
19rosacea10.7
20hidradenitis10.6
21synovitis10.6
22hyperostosis10.6
23sapho syndrome10.6
24pyoderma10.4
25pyoderma gangrenosum10.4
26osteomyelitis10.4
27folliculitis10.3
28pyogenic arthritis, pyoderma gangrenosum and acne10.3
29acne inversa, familial, 110.2
30frontalis acne10.2
31pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
32pseudotumor cerebri10.1
33cellulitis10.1
34endophthalmitis10.1
35acne inversa, familial, 310.1
36acne inversa, familial, 210.1
3721-hydroxylase deficiency10.1
38keratosis follicularis10.0
39subdural empyema10.0
40psoriatic arthritis10.0
41pityriasis rubra pilaris10.0
42keratosis10.0
43spondyloarthropathy10.0
44squamous cell carcinoma10.0
45uveitis10.0
46dowling-degos disease10.0
47retinol dystrophy, iris coloboma, and comedogenic acne syndrome10.0
48alzheimer's disease10.0PPARA, IL1A, SHBG, NCSTN, PSENEN, PSEN1
49cystic fibrosis10.0DEFB1, BTD, NF2, DEFB4A
50periodontal disease10.0DEFB4A, IL1A, DEFB1, TLR2

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Clinical Features for Acne

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Sources:
46OMIM
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Clinical features from OMIM:

604324

Drugs & Therapeutics for Acne

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Acne

Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Search CenterWatch for Acne

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

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Anatomical Context for Acne

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acne:

32
Skin, Ovary, Bone, Brain, Monocytes, Testes, Salivary gland, Lung, Liver, Colon, T cells

Animal Models for Acne or affiliated genes

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Publications for Acne

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Sources:
50PubMed
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Articles related to Acne:

(show top 50)    (show all 896)
idTitleAuthorsYear
1
Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. (24265031)
2014
2
The phototoxic and photoallergy potential of clindamycin phosphate 1.2%/ tretinoin 0.025% gel for facial acne: results of two single-center, evaluator-blinded, randomized, vehicle-controlled phase 1 studies in healthy volunteers. (24385115)
2014
3
Intense pulsed light versus benzoyl peroxide 5A % gel in treatment of acne vulgaris. (24114421)
2013
4
Resident Rounds. Part III A. Serendipitous improvement in moderate to severe acne in psoriasis patients treated with ustekinumab: a two-case series. (23839194)
2013
5
Clinical and bacteriological evaluation of adapalene 0.1% gel plus nadifloxacin 1% cream versus adapalene 0.1% gel in patients with acne vulgaris. (23724808)
2013
6
Acute and severe acne in a patient treated with bevacizumab. (23432695)
2013
7
The Role of Inflammation in the Pathology of Acne. (24062871)
2013
8
Treatment of acne vulgaris during pregnancy and lactation. (23657872)
2013
9
Percutaneous absorption and antibacterial activities of lipid nanocarriers loaded with dual drugs for acne treatment. (23370356)
2013
10
Polymorphisms in the promoters of MMP-2 and TIMP-2 genes in patients with acne vulgaris. (24260605)
2013
11
Acne inversa goes an extra mile than hidradenitis suppurativa. (24278084)
2013
12
The efficacy and safety of gamma-linolenic acid for the treatment of acne vulgaris. (23675697)
2013
13
Medication adherence, healthcare costs and utilization associated with acne drugs in Medicaid enrollees with acne vulgaris. (23572294)
2013
14
Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation. (24191156)
2013
15
Safety and efficacy of tazarotene foam for the treatment of acne vulgaris. (23696711)
2013
16
Cognitive behavioral therapy for acne and other chronic skin disorders. (23786756)
2013
17
Doxycycline-induced cutaneous inflammation with systemic symptoms in a patient with acne vulgaris. (23815962)
2013
18
Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris. (24168697)
2013
19
Acne and its management. (24187141)
2013
20
Hormonal profile and polycystic ovaries in women with acne vulgaris. (23619449)
2013
21
Short contact therapy of acne with tretinoin. (23167277)
2013
22
Tazarotene foam versus tazarotene gel: a randomized relative bioavailability study in acne vulgaris. (23456673)
2013
23
A novel topical ingredient derived from seaweed significantly reduces symptoms of acne vulgaris: a general literature review. (23752036)
2013
24
Doxycycline-isoniazid: a new therapeutic association for recalcitrant acne agminata. (22741939)
2012
25
Lipase, protease, and biofilm as the major virulence factors in staphylococci isolated from acne lesions. (23006962)
2012
26
Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. (22648222)
2012
27
Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. (22085193)
2012
28
Combined use of fractional CO2 laser and radiofrequency waves to treat acne scars: a pilot study on 15 patients. (22658207)
2012
29
"Tram track effect" after treatment of acne scars using a microneedling device. (22587597)
2012
30
Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway. (22684779)
2012
31
The tolerability profile of clindamycin 1%/benzoyl peroxide 5% gel vs. adapalene 0.1%/benzoyl peroxide 2.5% gel for facial acne: results of a randomized, single-blind, split-face study. (23174047)
2012
32
Role of the TNFA -308G > A polymorphism in the genetic susceptibility to acne vulgaris in a Sicilian population. (23193891)
2012
33
Five things to know about...: acne. (22353591)
2012
34
Combined oral contraceptives for the treatment of acne: a practical guide. (22988652)
2012
35
Comparison between the efficacy of Q-Switched 1064-nm Nd: YAG laser and Fraxel CO(2) laser on improvement of atrophic facial acne scars: A letter to editor. (22973357)
2011
36
Acne rosacea: effectiveness of 532 nm laser on the cosmetic appearance of the skin. (20470675)
2010
37
Increased enthesopathy among BehAset's syndrome patients with acne and arthritis: an ultrasonography study. (18438817)
2008
38
Creatine phosphokinase values during isotretinoin treatment for acne. (18377609)
2008
39
A case of SAPHO (synovitis-acne-pustulosis-hyperostosis-osteomyelitis) syndrome in which [18F]fluorodeoxyglucose positron emission tomography was useful for differentiating from multiple metastatic bone tumors. (17278026)
2007
40
Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. (16528362)
2006
41
Drugs for acne, rosacea and psoriasis. (15961971)
2005
42
The role of the antioxidative defense system in papulopustular acne. (11349462)
2001
43
Acne in Becker's nevus. (11737455)
2001
44
Effect of the bacillus of Calmette-GuAcrin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine. (10392627)
1999
45
Oral isotretinoin therapy in severe acne induces transient suppression of biochemical markers of bone turnover and calcium homeostasis. (9689293)
1998
46
Isotretinoin, tetracycline and circulating hormones in acne. (9298137)
1997
47
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
48
Psoriatic arthritis and synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. (8357739)
1993
49
Isoniazid-induced acne and pellagra. Occurrence in slow inactivators of isoniazid. (4273616)
1974
50
Hypochromic anemia with epithelial changes and acne rosacea. (21005788)
1945

Genetic Variations for Acne

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Expression for genes affiliated with Acne

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acne

Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems, 59Tocris Bioscience
See all sources

Pathways related to Acne according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL1A, PSEN1, PSENEN, PPARA, MT-ND4, MT-ND3
2
Hide members
10.8CYP21A2, BTD, MT-ATP8, MT-ND4L, MT-ND3, MT-ND4
3
Hide members
10.7PSEN1, PSENEN, PPARA, NCSTN, IL1A
410.7NF2, NCSTN, PSENEN, PSEN1
5
Hide members
10.7IL1A, NCSTN, PSEN1, TLR2
6
Hide members
10.6PSEN1, PSENEN, NCSTN
710.6PSEN1, PSENEN, NCSTN
810.6PSEN1, PSENEN, NCSTN
910.6PSEN1, PSENEN, NCSTN
1010.6PSEN1, PSENEN, NCSTN
11
Hide members
10.6NCSTN, PSENEN, PSEN1
1210.6NCSTN, PSENEN, PSEN1
1310.6NCSTN, PSENEN, PSEN1
14
Hide members
10.6DEFB4A, DEFB1, TLR2
15
Immune response Bacterial infections in normal airways
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10.6TLR2, DEFB4A, IL1A
16
Hide members
10.6NCSTN, PSENEN
1710.6PSENEN, PSEN1

Compounds for genes affiliated with Acne

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acne according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.3DEFB1, CYP21A2, SRD5A1, IL1A, SHBG, DEFB4A
2retinoic acid44 2412.3PSEN1, PPARA, DEFB4A, SHBG, IL1A, SRD5A1
3lipid4411.3CYP21A2, SHBG, NCSTN, DEFB4A, PPARA, PSENEN
4serine4411.3MT-ND3, TLR2, PSEN1, PSTPIP1, PPARA, NF2
5cholesterol44 28 11 2414.2TLR2, SHBG, PSEN1, PSENEN, NCSTN, CYP21A2
6arginine4411.2IL1A, PPARA, TLR2, SHBG, BTD, CYP21A2
7genistein44 28 59 2 11 2416.2SRD5A1, DEFB4A, IL1A, CYP21A2, PPARA, SHBG
8progesterone44 59 28 11 2415.2CYP21A2, NF2, SHBG, IL1A, SRD5A1, DEFB4A
9calcitriol44 59 11 2414.1IL1A, SHBG, SRD5A1, PPARA, TLR2
10vitamin d4411.1SRD5A1, TLR2, PPARA, SHBG, IL1A
11norepinephrine44 11 2413.1IL1A, PSEN1, PPARA, CYP21A2, SHBG
12ketoconazole44 28 11 2414.1SRD5A1, IL1A, CYP21A2, SHBG
13glucose4411.1DEFB1, BTD, PSEN1, CYP21A2
14biotin44 11 2413.1PSEN1, SHBG, CYP21A2, BTD
15hbd24411.1DEFB4A, TLR2, DEFB1
16alanine4411.0PSEN1, SHBG, MT-ND3, BTD, TLR2, PPARA
173-alpha-androstanediol glucuronide44 2412.0CYP21A2, SRD5A1, SHBG
1817-hydroxyprogesterone44 2412.0SHBG, SRD5A1, CYP21A2
19isotretinoin44 1112.0SRD5A1, BTD, PPARA
20simvastatin44 49 59 28 11 2416.0TLR2, IL1A, SHBG, PPARA
21polymyxin b4411.0IL1A, DEFB1, TLR2
22spironolactone49 44 59 28 1115.0SRD5A1, CYP21A2, SHBG
23valine4411.0PPARA, CYP21A2, MT-ND4, PSEN1
24mrk 5605911.0PSENEN, PSEN1
25jlk 65911.0PSEN1, PSENEN
26begacestat5911.0PSEN1, PSENEN
27cycloheximide4411.0PPARA, IL1A, PSEN1, TLR2, CYP21A2
28l-685,4585911.0PSENEN, PSEN1
29dapt5910.9PSENEN, PSEN1
30rantes4410.9DEFB1, TLR2, DEFB4A, IL1A
31dehydroepiandrosterone sulfate4410.9SHBG, SRD5A1, CYP21A2
32epitestosterone4410.9SRD5A1, SHBG
33phenytoin44 49 28 1113.9CYP21A2, SRD5A1, SHBG
34formestane4410.9SRD5A1, SHBG
35enterolactone4410.9SHBG, SRD5A1
36ment4410.9SHBG, SRD5A1
37dhea4410.9SRD5A1, CYP21A2, SHBG
38norgestimate44 1111.9SRD5A1, SHBG
39androstenediol4410.9SHBG, SRD5A1
40androstenedione44 2411.8CYP21A2, SRD5A1, SHBG
41nadh44 11 2412.8MT-ND4L, MT-ND3, MT-ATP8, MT-ND4
4217-hydroxypregnenolone4410.8CYP21A2, SHBG
43desogestrel44 1111.8SHBG, SRD5A1
44acarbose44 1111.7PPARA, SHBG
45goserelin44 28 1112.7SHBG, SRD5A1
4611 deoxycortisol4410.6CYP21A2, SHBG
47testosterone44 59 11 2413.6SRD5A1, CYP21A2, SHBG, IL1A, PPARA
48allopregnanolone4410.6SRD5A1, SHBG
49doca4410.6SRD5A1, CYP21A2
50trichloroethylene4410.3SHBG, PPARA

GO Terms for genes affiliated with Acne

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Sources:
16Gene Ontology
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Biological processes related to Acne according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:04298710.9NCSTN, PSENEN, PSEN1
2Notch receptor processingGO:00722010.8NCSTN, PSENEN, PSEN1
3membrane protein ectodomain proteolysisGO:00650910.8PSEN1, PSENEN, NCSTN
4protein processingGO:01648510.8NCSTN, PSENEN, PSEN1
5positive regulation of catalytic activityGO:04308510.8NCSTN, PSENEN, PSEN1
6beta-amyloid metabolic processGO:05043510.7PSEN1, NCSTN
7positive regulation of apoptotic processGO:04306510.7ACIN1, NCSTN, PSENEN, PSEN1
8epithelial cell proliferationGO:05067310.6NCSTN, PSEN1
9Notch signaling pathwayGO:00721910.6NCSTN, PSENEN, PSEN1
10membrane protein intracellular domain proteolysisGO:03129310.5PSENEN, NCSTN
11immune responseGO:00695510.4IL1A, DEFB4A, DEFB1, TLR2

Products for genes affiliated with Acne

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acne

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet