ACNE
MCID: ACN011
MIFTS: 54

Acne (ACNE) malady

Skin category

Summaries for Acne

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Acne, also known as acne, unspecified, is related to hidradenitis suppurativa and arthritis. An important gene associated with Acne is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. The compounds dexamethasone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver.

Wikipedia:64 Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of skin with... more...

Description from OMIM:47 604324

Aliases & Classifications for Acne

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 47OMIM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

acne 8 10 34 31 61
acne, unspecified 8


External Ids:

Disease Ontology8 DOID:6543
OMIM47 604324
NCIt40 C27195
ICD1025 L70, L70.9

Related Diseases for Acne

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acne via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa31.0PSENEN, NCSTN
2arthritis30.6IL1A, PSTPIP1, TLR2, PPARA
3alopecia30.4BTD, SHBG
4polycystic ovary syndrome30.4SHBG, CYP21A2, SRD5A1, PPARA
5hyperandrogenism30.3SRD5A1, CYP21A2, SHBG
6insulin resistance30.1PPARA, SHBG, CYP21A2
7atopic dermatitis30.1DEFB4A, TLR2
8congenital adrenal hyperplasia29.9CYP21A2, BTD, SRD5A1
9ulcerative colitis29.9DEFB4A, DEFB1, IL1A, TLR2
10sinusitis29.7DEFB4A
11klinefelter's syndrome29.7SRD5A1, CYP21A2, SHBG
12rosacea10.7
13synovitis10.6
14sapho syndrome10.6
15pyoderma gangrenosum10.4
16folliculitis10.3
17pyogenic arthritis, pyoderma gangrenosum and acne10.3
18n syndrome10.2
19acne inversa, familial, 110.2
20pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
21pseudotumor cerebri10.2
22cellulitis10.2
23synovitis, chronic10.2
24acne inversa, familial, 310.2
25acne inversa, familial, 210.2
26pyoderma gangrenosum - acne - suppurative hidradenitis10.2
27frontalis acne10.1
28isotretinoin syndrome10.1
29keratosis follicularis10.1
30subdural empyema10.1
31psoriatic arthritis10.1
32pityriasis rubra pilaris10.1
33spondyloarthropathy10.1
34squamous cell carcinoma10.1
35uveitis10.1
36dowling-degos disease10.1
37keloids10.1
38retinol dystrophy, iris coloboma, and comedogenic acne syndrome10.1
39alzheimer's disease10.0PPARA, IL1A, SHBG, NCSTN, PSENEN, PSEN1
40skin disease10.0DEFB4A, PPARA, TLR2, IL1A, SRD5A1
41cystic fibrosis10.0DEFB1, BTD, NF2, DEFB4A
42periodontitis10.0IL1A, DEFB4A, DEFB1, TLR2
43periodontal disease10.0DEFB4A, IL1A, DEFB1, TLR2
44adenocarcinoma10.0NF2, PPARA, SRD5A1, CYP21A2
45androgenic alopecia10.0SHBG, CYP21A2, SRD5A1
46dermatitis10.0IL1A, BTD, PPARA
47metabolic syndrome x10.0PPARA, CYP21A2, BTD, SHBG
48psoriasis10.0IL1A, TLR2, PPARA, DEFB4A
49breast cancer10.0SRD5A1, CYP21A2, PPARA, NF2, SHBG
50anovulation10.0CYP21A2, SHBG, SRD5A1

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Clinical Features for Acne

Sources:
47OMIM
See all sources

Clinical features from OMIM:

604324

Drugs & Therapeutics for Acne

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Acne

Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Search CenterWatch for Acne

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

Anatomical Context for Acne

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acne:

33
Skin, Ovary, Liver, Brain, Lung, Colon, Salivary gland, Adrenal gland, Breast, Monocytes, T cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Acne or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Acne

Sources:
51PubMed
See all sources

Articles related to Acne:

(show top 50)    (show all 926)
idTitleAuthorsYear
1
Relationships of Self-Reported Dietary Factors and Perceived Acne Severity in a Cohort of New York Young Adults. (24412232)
2014
2
Which factors influence quality of life in acne patients? (23240552)
2014
3
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy. (23673498)
2013
4
Resident Rounds. Part III A. Serendipitous improvement in moderate to severe acne in psoriasis patients treated with ustekinumab: a two-case series. (23839194)
2013
5
Propionibacterium acnes activates caspase-1 in human neutrophils. (23278288)
2013
6
Treatment of acne scars and wrinkles in asian patients using carbon-dioxide fractional laser resurfacing: its effects on skin biophysical profiles. (24371392)
2013
7
Evidence on acne therapy. (23903269)
2013
8
Treating acne scars in patients with Fitzpatrick skin types IV to VI using the 1450-nm diode laser. (23961527)
2013
9
Novel techniques for enhancement and segmentation of acne vulgaris lesions. (24329769)
2013
10
Commentary: salicylic acid peels versus Jessner's solution peels for acne vulgaris: a comparative study. (23387358)
2013
11
Intense pulsed light enhances transforming growth factor beta1/Smad3 signaling in acne-prone skin. (23992161)
2013
12
Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients. (24313686)
2013
13
A brief primer on acne therapy for adolescents with skin of color. (23961520)
2013
14
Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. (23458393)
2013
15
Extended-release Formulation of Minocycline in the Treatment of Moderate-to-severe Acne Vulgaris in Patients Over the Age of 12 Years. (23882310)
2013
16
Etiologic link between sarcoidosis and Propionibacterium acnes. (23790733)
2013
17
Home laser treatments: acne, aging, and unwanted hair. (22527442)
2012
18
A split-face comparison of a fractional microneedle radiofrequency device and fractional carbon dioxide laser therapy in acne patients. (23016530)
2012
19
A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. (22395584)
2012
20
Staphylococcus aureus in Acne Pathogenesis: A Case-Control Study. (23181229)
2012
21
Physical and psychosocial impact of acne in adult females. (22470204)
2012
22
Role of growth hormone and insulin-like growth factor-I in hyperandrogenism and the severity of acne vulgaris in young males. (23147876)
2012
23
Effects of fish oil supplementation on inflammatory acne. (23206895)
2012
24
Mediterranean diet and familial dysmetabolism as factors influencing the development of acne. (22833557)
2012
25
Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris. (22705603)
2012
26
New antibiotic therapies for acne and rosacea. (22591497)
2012
27
Acne & rosacea: thinking outside the box. (23377506)
2012
28
Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study. (22105812)
2012
29
Acne and diet: facts and controversies. (23069302)
2012
30
What's new in antibiotics in the management of acne? (22648324)
2012
31
Tretinoin microsphere gel 0.04% pump for treating acne vulgaris in preadolescents: a randomized, controlled study. (22712470)
2012
32
Clinical inquiries. What is the most effective treatment for acne rosacea? (21301648)
2011
33
Correlation and agreement of self-assessed and objective skin disease severity in a cross-sectional study of patients with acne, psoriasis, and atopic eczema. (22097994)
2011
34
Acne and dairy products. (22360052)
2011
35
Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis. (19659829)
2010
36
Aczone, a topical gel formulation of the antibacterial, anti-inflammatory dapsone for the treatment of acne. (19431080)
2009
37
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate. (19539848)
2009
38
Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne. (19525031)
2009
39
CD209(+) macrophages mediate host defense against Propionibacterium acnes. (18354216)
2008
40
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation. (16778789)
2007
41
In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions. (17518990)
2007
42
Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris. (15283020)
2004
43
Acneiform follicular mucinosis of the head and neck region. (12695140)
2003
44
Diffuse chronic sclerosing osteomyelitis and the synovitis, acne, pustolosis, hyperostosis, osteitis (SAPHO) syndrome in two sisters. (10691145)
2000
45
Exocellular phospholipase C activity from a Propionibacterium acnes strain isolated from a periodontal pocket. (9150042)
1997
46
Keratin expression in pilosebaceous epithelia in truncal skin of acne patients. (8746337)
1996
47
Acne fulminans coexisting with pyoderma gangrenosum-like eruptions and posterior scleritis. (8720256)
1996
48
Anterior mediastinal fibrosis with superior vena caval obstruction complicating the synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome. (8495263)
1993
49
Demodectic eruptions (demodicidosis) in the human. 30 years' experience with 2 commonly unrecognized entities: pityriasis folliculorum (Demodex) and acne rosacea (Demodex type). (13685388)
1961
50
Hypochromic anemia with epithelial changes and acne rosacea. (21005788)
1945

Genetic Variations for Acne

Expression for genes affiliated with Acne

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acne

Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems, 60Tocris Bioscience
See all sources

Pathways related to Acne according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL1A, PSEN1, PSENEN, PPARA, MT-ND4, MT-ND3
2
Hide members
10.8CYP21A2, BTD, MT-ATP8, MT-ND4L, MT-ND3, MT-ND4
3
Hide members
10.7PSEN1, PSENEN, PPARA, NCSTN, IL1A
410.7NF2, NCSTN, PSENEN, PSEN1
5
Hide members
10.7IL1A, NCSTN, PSEN1, TLR2
6
Hide members
10.6PSEN1, PSENEN, NCSTN
710.6PSEN1, PSENEN, NCSTN
810.6PSEN1, PSENEN, NCSTN
910.6PSEN1, PSENEN, NCSTN
1010.6PSEN1, PSENEN, NCSTN
11
Hide members
10.6NCSTN, PSENEN, PSEN1
1210.6NCSTN, PSENEN, PSEN1
1310.6NCSTN, PSENEN, PSEN1
14
Hide members
10.6DEFB4A, DEFB1, TLR2
15
Immune response Bacterial infections in normal airways
Hide members
10.6TLR2, DEFB4A, IL1A
16
Hide members
10.6NCSTN, PSENEN
1710.6PSENEN, PSEN1

Compounds for genes affiliated with Acne

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Acne according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1114.3SRD5A1, TLR2, PPARA, DEFB1, DEFB4A, SHBG
2retinoic acid45 2412.3TLR2, PSEN1, PPARA, DEFB1, DEFB4A, SHBG
3lipid4511.3TLR2, PSEN1, PSENEN, PPARA, DEFB4A, NCSTN
4serine4511.3TLR2, PSEN1, PSTPIP1, PPARA, MT-ND3, NF2
5cholesterol45 29 11 2414.2TLR2, PSEN1, PSENEN, PPARA, NCSTN, SHBG
6arginine4511.2TLR2, PSEN1, PPARA, SHBG, BTD, CYP21A2
7genistein45 29 60 2 11 2416.2PPARA, DEFB4A, SHBG, CYP21A2, IL1A, SRD5A1
8progesterone45 60 29 11 2415.2DEFB4A, SHBG, NF2, CYP21A2, IL1A, SRD5A1
9calcitriol45 60 11 2414.1TLR2, PPARA, SHBG, IL1A, SRD5A1
10vitamin d4511.1TLR2, PPARA, SHBG, IL1A, SRD5A1
11norepinephrine45 11 2413.1PSEN1, PPARA, SHBG, CYP21A2, IL1A
12ketoconazole45 29 11 2414.1SHBG, CYP21A2, IL1A, SRD5A1
13glucose4511.1PSEN1, DEFB1, BTD, CYP21A2
14biotin45 11 2413.1PSEN1, SHBG, BTD, CYP21A2
15hbd24511.1DEFB4A, DEFB1, TLR2
16alanine4511.0TLR2, PSEN1, PPARA, MT-ND3, SHBG, BTD
173-alpha-androstanediol glucuronide45 2412.0SHBG, CYP21A2, SRD5A1
1817-hydroxyprogesterone45 2412.0SHBG, CYP21A2, SRD5A1
19simvastatin45 50 60 29 11 2416.0TLR2, PPARA, SHBG, IL1A
20isotretinoin45 1112.0PPARA, BTD, SRD5A1
21polymyxin b4511.0TLR2, DEFB1, IL1A
22spironolactone50 45 60 29 1115.0SHBG, CYP21A2, SRD5A1
23valine4511.0PSEN1, PPARA, MT-ND4, CYP21A2
24mrk 5606011.0PSEN1, PSENEN
25jlk 66011.0PSEN1, PSENEN
26begacestat6011.0PSEN1, PSENEN
27cycloheximide4511.0TLR2, PSEN1, PPARA, CYP21A2, IL1A
28l-685,4586011.0PSEN1, PSENEN
29dapt6010.9PSEN1, PSENEN
30rantes4510.9TLR2, DEFB1, DEFB4A, IL1A
31dehydroepiandrosterone sulfate4510.9SRD5A1, CYP21A2, SHBG
32epitestosterone4510.9SHBG, SRD5A1
33phenytoin45 50 29 1113.9SHBG, CYP21A2, SRD5A1
34ment4510.9SHBG, SRD5A1
35formestane4510.9SHBG, SRD5A1
36enterolactone4510.9SHBG, SRD5A1
37dhea4510.9SRD5A1, CYP21A2, SHBG
38norgestimate45 1111.9SRD5A1, SHBG
39androstenediol4510.9SRD5A1, SHBG
40androstenedione45 2411.8SRD5A1, CYP21A2, SHBG
41nadh45 11 2412.8MT-ATP8, MT-ND4L, MT-ND3, MT-ND4
4217-hydroxypregnenolone4510.8CYP21A2, SHBG
43acarbose45 1111.8PPARA, SHBG
44desogestrel45 1111.7SHBG, SRD5A1
45doca4510.7CYP21A2, SRD5A1
4611 deoxycortisol4510.6SHBG, CYP21A2
47testosterone45 60 11 2413.6PPARA, SHBG, CYP21A2, IL1A, SRD5A1
48goserelin45 29 1112.6SHBG, SRD5A1
49allopregnanolone4510.6SRD5A1, SHBG
50trichloroethylene4510.3SHBG, PPARA

GO Terms for genes affiliated with Acne

Sources:
16Gene Ontology
See all sources

Biological processes related to Acne according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:04298710.9NCSTN, PSENEN, PSEN1
2Notch receptor processingGO:00722010.8NCSTN, PSENEN, PSEN1
3membrane protein ectodomain proteolysisGO:00650910.8PSEN1, PSENEN, NCSTN
4protein processingGO:01648510.8NCSTN, PSENEN, PSEN1
5positive regulation of catalytic activityGO:04308510.8NCSTN, PSENEN, PSEN1
6beta-amyloid metabolic processGO:05043510.7PSEN1, NCSTN
7positive regulation of apoptotic processGO:04306510.7ACIN1, NCSTN, PSENEN, PSEN1
8epithelial cell proliferationGO:05067310.6NCSTN, PSEN1
9Notch signaling pathwayGO:00721910.6NCSTN, PSENEN, PSEN1
10membrane protein intracellular domain proteolysisGO:03129310.5PSENEN, NCSTN
11immune responseGO:00695510.4IL1A, DEFB4A, DEFB1, TLR2

Products for genes affiliated with Acne

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acne

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet