ACNE
MCID: ACN011
MIFTS: 56

Acne (ACNE) malady

Skin diseases category
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Summaries for Acne

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Acne, also known as acne, unspecified, is related to hidradenitis suppurativa and synovitis. An important gene associated with Acne is NCSTN (nicastrin), and among its related pathways are Nuclear signaling by ERBB4 and Signaling by NOTCH2. The compounds dapt and begacestat have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and bone, and related mouse phenotypes are cardiovascular system and immune system.

Wikipedia:65 Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of seborrhea... more...

Description from OMIM:47 604324

Aliases & Classifications for Acne

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 47OMIM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

acne 8 10 34 31 62
acne, unspecified 8


External Ids:

Disease Ontology8 DOID:6543
OMIM47 604324
NCIt40 C27195
ICD1025 L70, L70.9

Related Diseases for Acne

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acne via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa31.1NCSTN, PSENEN
2synovitis30.9TLR2, IL1A
3alopecia30.6SHBG
4arthritis30.6TLR2, IL1A, PSTPIP1
5psoriasis30.5TLR2, DEFB4A, IL1A
6polycystic ovary syndrome30.5SHBG, CYP21A2
7hyperandrogenism30.4SHBG, CYP21A2
8sarcoidosis30.4DEFB4A, IL1A, DEFB1
9skin disease30.3IL1A, DEFB4A, TLR2
10insulin resistance30.2RBP4, SHBG, CYP21A2
11psoriatic arthritis30.1TLR2, IL1A
12atopic dermatitis30.1DEFB4A, TLR2
13inflammatory bowel disease30.0DEFB4A, PSTPIP1, DEFB1, TLR2
14candidiasis29.9DEFB4A
15ulcerative colitis29.9DEFB1, TLR2, IL1A, DEFB4A
16klinefelter's syndrome29.8SHBG, CYP21A2
17periodontitis29.8IL1A, TLR2
18osteoarthritis29.7TLR2, IL1A, DEFB4A
19pneumonia29.7DEFB4A, DEFB1, TLR2, RBP4
20obesity29.6SHBG, CYP21A2, TLR2, RBP4
21rosacea10.7
22hidradenitis10.7
23hyperostosis10.6
24sapho syndrome10.6
25blindness10.5
26pyoderma10.5
27pyogenic arthritis, pyoderma gangrenosum and acne10.4
28pyoderma gangrenosum10.4
29osteomyelitis10.4
30folliculitis10.4
31pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.3
32dermatitis10.3
33acne inversa, familial, 110.3
34frontalis acne10.2
35dissecting cellulitis of the scalp10.2
36pseudotumor cerebri10.2
37cellulitis10.2
38endophthalmitis10.2
39keloids10.2
40acne inversa, familial, 310.2
41acne inversa, familial, 210.2
4221-hydroxylase deficiency10.1
43oral candidiasis10.1DEFB4A
44keratosis follicularis10.1
45pityriasis rubra pilaris10.1
46subdural empyema10.1
47keratosis10.1
48spondyloarthropathy10.1
49uveitis10.1
50chronic recurrent multifocal osteomyelitis10.1

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Symptoms for Acne

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Sources:
47OMIM
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Clinical features from OMIM:

604324

Drugs & Therapeutics for Acne

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

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Anatomical Context for Acne

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Sources:
33MalaCards
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MalaCards organs/tissues related to Acne:

33
Skin, Ovary, Bone, Brain, Monocytes, Testes, Salivary gland, Lung, Liver, Colon, T cells

Animal Models for Acne or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Acne:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1TLR2, PSEN1, IL1A, NCSTN, RBP4
2MP:00053877.4DEFB1, TLR2, PSEN1, PSTPIP1, IL1A, NCSTN

Publications for Acne

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Sources:
52PubMed
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Articles related to Acne:

(show top 50)    (show all 888)
idTitleAuthorsYear
1
Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. (24265031)
2014
2
Randomized clinical trial of CO2 LASER pinpoint irradiation technique versus chemical reconstruction of skin scars (CROSS) in treating ice pick acne scars. (24131091)
2013
3
Comparative antimicrobial efficacy of Metapex, Metronidazole, BioPure MTAD, Aztreonam on Bacteroides fragilis and Propionibacterium acne. (23956535)
2013
4
Comparison of Fractional, Non-ablative, 1550-nm Laser and 595-nm, Pulsed Dye Laser for the Treatment of Facial Erythema Resulting from Acne: A Split-face, Evaluator-blinded, Randomized Pilot Study. (24131072)
2013
5
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy. (23673498)
2013
6
Comparison of fractional erbium-doped yttrium aluminum garnet and carbon dioxide lasers in resurfacing of atrophic acne scars in Asians. (23205717)
2013
7
Absence of pathogenic I^-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). (23013355)
2013
8
Efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. (24250593)
2013
9
Intense pulsed light versus benzoyl peroxide 5A % gel in treatment of acne vulgaris. (24114421)
2013
10
What's new in acne and inflammation? (23839203)
2013
11
Concomitant antibiotic usage does not augment the risk of inflammatory bowel disease with isotretinoin treatment for acne: a review of the Food and Drug Administration Adverse Event Reporting System. (23052415)
2013
12
A phase IV, open-label study evaluating the use of triple-combination therapy with minocycline HCl extended-release tablets, a topical antibiotic/retinoid preparation and benzoyl peroxide in patients with moderate to severe acne vulgaris. (23839176)
2013
13
Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne. (23545906)
2013
14
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
15
Home laser treatments: acne, aging, and unwanted hair. (22527442)
2012
16
Over-the-counter Acne Treatments: A Review. (22808307)
2012
17
Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial. (22678562)
2012
18
Effects of isotretinoin on social anxiety and quality of life in patients with acne vulgaris: a prospective trial. (22726279)
2012
19
Doxycycline-isoniazid: a new therapeutic association for recalcitrant acne agminata. (22741939)
2012
20
Minocycline in the management of acne vulgaris: the challenge of conveying pharmacovigilance data to primary care. (22626037)
2012
21
Management of acne scarring, part I: a comparative review of laser surgical approaches. (22612738)
2012
22
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
23
A split-face comparison of a fractional microneedle radiofrequency device and fractional carbon dioxide laser therapy in acne patients. (23016530)
2012
24
Photodynamic therapy with intralesional 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: a comparative study. (22591502)
2012
25
Do automated text messages increase adherence to acne therapy? Results of a randomized, controlled trial. (22521201)
2012
26
Efficacy and tolerability of topical 0.2% MyrtacineAr and 4% vitamin PP for prevention and treatment of retinoid dermatitis in patients with mild to moderate acne. (23007255)
2012
27
Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study. (22585103)
2012
28
Comparison of Q-Switched 1064-nm Nd: YAG laser and fractional CO2 laser efficacies on improvement of atrophic facial acne scar. (22973388)
2011
29
D-penicillamine induced elastosis perforans serpiginosa mimicking acne keloidalis nuchae. (21965866)
2011
30
IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes. (20130231)
2010
31
Tibial chronic osteomyelitis due to Propionibacterium acnes in a patient with sickle cell anemia. (19913448)
2010
32
Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris. (20630038)
2010
33
Updates on the pathophysiology and management of acne rosacea. (19820288)
2009
34
The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. (19563582)
2009
35
Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema. (19236289)
2009
36
Concentration of selected cytokines in serum of patients with acne rosacea]. (19140384)
2008
37
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
38
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
39
Rosacea/acne rosacea: efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment. (18435734)
2008
40
Acne keloidalis: a novel presentation for tinea capitis. (17141363)
2007
41
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation. (16778789)
2007
42
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
43
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
44
Acne in the male resistant to isotretinoin and responsibility of androgens: 9 cases, therapeutic implications]. (10095884)
1999
45
Androgen metabolism in sebaceous glands from subjects with and without acne. (10490108)
1999
46
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
47
Clinical and hormonal effects of ethinylestradiol combined with gestodene and desogestrel in young women with acne vulgaris. (8689881)
1996
48
Inflammatory levels of interleukin 1 alpha are present in the majority of open comedones in acne vulgaris. (1830734)
1991
49
Essential-fatty-acid metabolites in plasma phospholipids in patients with ichthyosis vulgaris, acne vulgaris and psoriasis. (2142029)
1990
50
Hemihypertrophy with unilateral folliculitis and acne. (161466)
1979

Variations for Acne

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Expression for genes affiliated with Acne

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acne

Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 61Tocris Bioscience, 5Cell Signaling Technology, 54R&D Systems, 53QIAGEN, 60Thomson Reuters
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Pathways related to Acne according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9PSENEN, NCSTN
2
Show member pathways
9.9NCSTN, PSENEN
3
Show member pathways
Notch signaling pathway38
9.9PSENEN, NCSTN
49.8PSENEN, PSEN1
59.5NCSTN, PSEN1, PSENEN
6
Show member pathways
Alzheimers Disease38
9.5PSENEN, NCSTN, PSEN1
79.5NCSTN, PSEN1, PSENEN
89.5NCSTN, PSENEN, PSEN1
99.5PSENEN, NCSTN, PSEN1
109.5NCSTN, PSENEN, PSEN1
11
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
9.5PSENEN, PSEN1, NCSTN
12
Show member pathways
9.5PSEN1, NCSTN, PSENEN
139.5PSEN1, NCSTN, PSENEN
14
Show member pathways
Development Notch Signaling Pathway60
Transcription Sin3 and NuRD in transcription regulation60
9.0PSENEN, PSEN1, IL1A, NCSTN
15
Show member pathways
8.8DEFB1, DEFB4A, TLR2
16
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7IL1A, TLR2, DEFB4A
17
Show member pathways
8.5NCSTN, PSEN1, TLR2, IL1A

Compounds for genes affiliated with Acne

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Sources:
61Tocris Bioscience, 45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Acne according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1dapt6110.2PSENEN, PSEN1
2begacestat6110.2PSEN1, PSENEN
3jlk 66110.2PSEN1, PSENEN
4l-685,4586110.2PSENEN, PSEN1
5mrk 5606110.2PSENEN, PSEN1
617-hydroxypregnenolone459.7CYP21A2, SHBG
711 deoxycortisol459.7CYP21A2, SHBG
8leuprolide acetate459.6CYP21A2, SHBG
9ciprofloxacin45 51 1111.6IL1A, DEFB1
10clomiphene citrate459.6SHBG, CYP21A2
11hcec459.5DEFB4A, TLR2
123-alpha-androstanediol glucuronide45 2410.5SHBG, CYP21A2
13valine459.4PSEN1, RBP4, CYP21A2
14flagellin45 2910.4TLR2, DEFB4A
15dehydroepiandrosterone sulfate459.4CYP21A2, RBP4, SHBG
16androstenedione45 2410.4RBP4, SHBG, CYP21A2
17biotin45 24 1111.3CYP21A2, SHBG, PSEN1
1817-hydroxyprogesterone45 2410.3CYP21A2, SHBG
19thyroxine45 2410.3RBP4, CYP21A2, SHBG
20imiquimod45 61 29 1112.2TLR2, IL1A
21hbd2459.2DEFB4A, DEFB1, TLR2
22nacl459.2DEFB4A, CYP21A2, DEFB1
23ketoconazole45 29 24 1112.2CYP21A2, SHBG, IL1A
24hydrocortisone45 3 61 1112.2SHBG, CYP21A2, IL1A
25polymyxin b459.1TLR2, DEFB1, IL1A
26ascorbic acid45 2410.1SHBG, IL1A, RBP4
27acth459.1CYP21A2, SHBG, IL1A
28ionomycin459.1TLR2, IL1A, PSEN1
29aspartate459.1PSEN1, SHBG, IL1A, RBP4
30endotoxin459.1IL1A, DEFB4A, TLR2
31spironolactone45 61 29 51 1113.0CYP21A2, SHBG
32calcitriol45 61 24 1111.9TLR2, SHBG, IL1A
33norepinephrine45 24 1110.8PSEN1, IL1A, SHBG, CYP21A2
34genistein45 29 61 3 24 1113.8CYP21A2, SHBG, IL1A, DEFB4A
35steroid458.8CYP21A2, DEFB4A, SHBG, RBP4
36testosterone45 61 24 1111.7CYP21A2, SHBG, IL1A, RBP4
37epinephrine45 24 1110.7CYP21A2, SHBG, IL1A
38simvastatin45 51 61 29 24 1113.7RBP4, IL1A, SHBG, TLR2
39rantes458.7IL1A, TLR2, DEFB1, DEFB4A
40leucine458.7CYP21A2, TLR2, RBP4, PSEN1
41ribonucleic acid458.6IL1A, CYP21A2, RBP4, TLR2
42progesterone45 29 61 24 1112.5CYP21A2, DEFB4A, SHBG, IL1A, RBP4
43cycloheximide458.5IL1A, TLR2, PSEN1, CYP21A2
44arginine458.0CYP21A2, PSEN1, SHBG, TLR2, IL1A
45serine457.9CYP21A2, RBP4, IL1A, TLR2, PSTPIP1, PSEN1
46glucose457.8SHBG, RBP4, PSEN1, TLR2, DEFB1, CYP21A2
47cholesterol45 29 24 1110.7RBP4, CYP21A2, TLR2, SHBG, PSEN1, PSENEN
48retinoic acid45 248.5RBP4, DEFB1, DEFB4A, TLR2, IL1A, SHBG
49lipid457.2PSENEN, PSEN1, SHBG, CYP21A2, DEFB4A, RBP4
50dexamethasone45 51 29 1110.2RBP4, TLR2, CYP21A2, SHBG, IL1A, DEFB1

GO Terms for genes affiliated with Acne

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Sources:
16Gene Ontology
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Cellular components related to Acne according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7NCSTN, PSENEN, PSEN1, TLR2
2extracellular regionGO:0055767.9RBP4, IL1A, SHBG, DEFB1, DEFB4A

Biological processes related to Acne according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.0NCSTN, PSEN1
2membrane protein intracellular domain proteolysisGO:03129310.0PSENEN, NCSTN
3epithelial cell proliferationGO:05067310.0PSEN1, NCSTN
4amyloid precursor protein catabolic processGO:0429879.8NCSTN, PSENEN, PSEN1
5membrane protein ectodomain proteolysisGO:0065099.8PSEN1, PSENEN, NCSTN
6Notch receptor processingGO:0072209.8NCSTN, PSENEN, PSEN1
7protein processingGO:0164859.8PSEN1, PSENEN, NCSTN
8positive regulation of catalytic activityGO:0430859.8NCSTN, PSENEN, PSEN1
9Notch signaling pathwayGO:0072199.7NCSTN, PSENEN, PSEN1
10positive regulation of apoptotic processGO:0430659.4NCSTN, PSENEN, PSEN1
11response to insulinGO:0328689.3RBP4, TLR2
12positive regulation of cytokine secretionGO:0507159.1TLR2, IL1A
13innate immune responseGO:0450878.5PSTPIP1, TLR2, DEFB1, DEFB4A
14inflammatory responseGO:0069548.5IL1A, PSTPIP1, TLR2
15immune responseGO:0069558.5DEFB4A, DEFB1, TLR2, IL1A

Molecular functions related to Acne according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:0041759.8NCSTN, PSEN1

Products for genes affiliated with Acne

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acne

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet