MCID: ACN011
MIFTS: 58

Acne malady

Skin diseases category

Summaries for Acne

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MedlinePlus:32 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Acne, also known as acne vulgaris, is related to hidradenitis suppurativa and alopecia. An important gene associated with Acne is NCSTN (nicastrin), and among its related pathways are Nuclear signaling by ERBB4 and Signaling by NOTCH2. The drugs isotretinoin and erythromycin pwdr and the compounds dapt and begacestat have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and monocytes, and related mouse phenotypes are cardiovascular system and immune system.

Disease Ontology:9 A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.

Wikipedia:63 Acne vulgaris (or simply acne) is a chronic skin condition characterized by areas of blackheads,... more...

Aliases & Classifications for Acne

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Acne, Aliases & Descriptions:

Name: Acne 30 9 11 32 60
Acne Vulgaris 9 43 60
 
Acne Varioliformis 9 60
Frontalis Acne 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Acne

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Diseases related to Acne via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa31.6NCSTN, PSENEN
2alopecia31.1SHBG
3synovitis30.9TLR2, IL1A
4polycystic ovary syndrome30.7SHBG, CYP21A2
5hyperandrogenism30.6SHBG, CYP21A2
6candidiasis30.4DEFB4A
7arthritis30.4TLR2, IL1A, PSTPIP1
8psoriasis30.3TLR2, DEFB4A, IL1A
9skin disease30.3IL1A, DEFB4A, TLR2
10atopic dermatitis30.2DEFB4A, TLR2
11psoriatic arthritis30.2TLR2, IL1A
12oligomenorrhea30.0SHBG, CYP21A2
13acanthosis nigricans30.0SHBG, CYP21A2
14klinefelter's syndrome29.9SHBG, CYP21A2
15periodontitis29.9IL1A, TLR2
16colitis29.9TLR2, DEFB1, DEFB4A
17inflammatory bowel disease29.8DEFB4A, PSTPIP1, DEFB1, TLR2
18ulcerative colitis29.5DEFB1, TLR2, IL1A, DEFB4A
19osteoarthritis29.5TLR2, IL1A, DEFB4A
20pneumonia29.4DEFB4A, DEFB1, TLR2, RBP4
21obesity29.2SHBG, CYP21A2, TLR2, RBP4
22rosacea10.7
23hidradenitis10.7
24hyperostosis10.7
25sapho syndrome10.7
26blindness10.6
27pyogenic arthritis, pyoderma gangrenosum and acne10.5
28pyoderma10.5
29pyoderma gangrenosum10.5
30oral candidiasis10.5DEFB4A
31osteomyelitis10.4
32folliculitis10.4
33acne inversa, familial, 110.3
34acne inversa, familial, 310.3
35pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.3
36dermatitis10.3
37tonsillitis10.3DEFB4A, DEFB1
38acne inversa, familial, 210.3
39duodenal ulcer10.3DEFB4A, DEFB1
40leprosy10.3TLR2
41middle ear cholesteatoma10.2IL1A, DEFB4A
42retinol dystrophy, iris coloboma, and comedogenic acne syndrome10.2
43dissecting cellulitis of the scalp10.2
44mody, type ii10.2RBP4, SHBG
45keloids10.2
46pseudotumor cerebri10.2
47cellulitis10.2
48endophthalmitis10.2
49hypothyroidism10.2SHBG, IL1A
50alopecia, androgenetic, 110.1CYP21A2, SHBG

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Symptoms for Acne

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Drugs & Therapeutics for Acne

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Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

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Anatomical Context for Acne

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MalaCards organs/tissues related to Acne:

31
Skin, Ovary, Monocytes, Neutrophil, Bone, Brain, Spinal cord, Colon, Liver, Lung, Salivary gland, Testes, T cells, B cells

Animal Models for Acne or affiliated genes

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MGI Mouse Phenotypes related to Acne:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1RBP4, NCSTN, IL1A, PSEN1, TLR2
2MP:00053877.4NCSTN, DEFB1, TLR2, PSEN1, PSTPIP1, IL1A

Publications for Acne

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Articles related to Acne:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris. (25853176)
2015
2
Multi-drugs resistant acne rosacea in a child affected by Ataxia-Telangiectasia: successful treatment with Isotretinoin. (25881033)
2015
3
Randomized Split-Face Controlled Study to Evaluate 1550-nm Fractionated Erbium Glass Laser for Treatment of Acne Vulgaris-An Image Analysis Evaluation. (25310750)
2014
4
Randomized clinical trial of CO2 LASER pinpoint irradiation technique versus chemical reconstruction of skin scars (CROSS) in treating ice pick acne scars. (24131091)
2013
5
Comparative antimicrobial efficacy of Metapex, Metronidazole, BioPure MTAD, Aztreonam on Bacteroides fragilis and Propionibacterium acne. (23956535)
2013
6
Comparison of Fractional, Non-ablative, 1550-nm Laser and 595-nm, Pulsed Dye Laser for the Treatment of Facial Erythema Resulting from Acne: A Split-face, Evaluator-blinded, Randomized Pilot Study. (24131072)
2013
7
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy. (23673498)
2013
8
Comparison of fractional erbium-doped yttrium aluminum garnet and carbon dioxide lasers in resurfacing of atrophic acne scars in Asians. (23205717)
2013
9
Absence of pathogenic I^-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). (23013355)
2013
10
Efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. (24250593)
2013
11
Intense pulsed light versus benzoyl peroxide 5A % gel in treatment of acne vulgaris. (24114421)
2013
12
What's new in acne and inflammation? (23839203)
2013
13
Concomitant antibiotic usage does not augment the risk of inflammatory bowel disease with isotretinoin treatment for acne: a review of the Food and Drug Administration Adverse Event Reporting System. (23052415)
2013
14
A phase IV, open-label study evaluating the use of triple-combination therapy with minocycline HCl extended-release tablets, a topical antibiotic/retinoid preparation and benzoyl peroxide in patients with moderate to severe acne vulgaris. (23839176)
2013
15
Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne. (23545906)
2013
16
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
17
Home laser treatments: acne, aging, and unwanted hair. (22527442)
2012
18
Over-the-counter Acne Treatments: A Review. (22808307)
2012
19
Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial. (22678562)
2012
20
Effects of isotretinoin on social anxiety and quality of life in patients with acne vulgaris: a prospective trial. (22726279)
2012
21
Doxycycline-isoniazid: a new therapeutic association for recalcitrant acne agminata. (22741939)
2012
22
Minocycline in the management of acne vulgaris: the challenge of conveying pharmacovigilance data to primary care. (22626037)
2012
23
Management of acne scarring, part I: a comparative review of laser surgical approaches. (22612738)
2012
24
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
25
A split-face comparison of a fractional microneedle radiofrequency device and fractional carbon dioxide laser therapy in acne patients. (23016530)
2012
26
Photodynamic therapy with intralesional 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: a comparative study. (22591502)
2012
27
Do automated text messages increase adherence to acne therapy? Results of a randomized, controlled trial. (22521201)
2012
28
Efficacy and tolerability of topical 0.2% MyrtacineAr and 4% vitamin PP for prevention and treatment of retinoid dermatitis in patients with mild to moderate acne. (23007255)
2012
29
Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study. (22585103)
2012
30
Comparison of Q-Switched 1064-nm Nd: YAG laser and fractional CO2 laser efficacies on improvement of atrophic facial acne scar. (22973388)
2011
31
IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes. (20130231)
2010
32
Tibial chronic osteomyelitis due to Propionibacterium acnes in a patient with sickle cell anemia. (19913448)
2010
33
Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris. (20630038)
2010
34
Updates on the pathophysiology and management of acne rosacea. (19820288)
2009
35
The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. (19563582)
2009
36
Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema. (19236289)
2009
37
Concentration of selected cytokines in serum of patients with acne rosacea]. (19140384)
2008
38
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
39
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
40
Rosacea/acne rosacea: efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment. (18435734)
2008
41
Acne keloidalis: a novel presentation for tinea capitis. (17141363)
2007
42
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
43
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
44
Acne in the male resistant to isotretinoin and responsibility of androgens: 9 cases, therapeutic implications]. (10095884)
1999
45
Androgen metabolism in sebaceous glands from subjects with and without acne. (10490108)
1999
46
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
47
Clinical and hormonal effects of ethinylestradiol combined with gestodene and desogestrel in young women with acne vulgaris. (8689881)
1996
48
Inflammatory levels of interleukin 1 alpha are present in the majority of open comedones in acne vulgaris. (1830734)
1991
49
Essential-fatty-acid metabolites in plasma phospholipids in patients with ichthyosis vulgaris, acne vulgaris and psoriasis. (2142029)
1990
50
Hemihypertrophy with unilateral folliculitis and acne. (161466)
1979

Variations for Acne

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Expression for genes affiliated with Acne

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Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

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Pathways related to Acne according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9NCSTN, PSENEN
2
Show member pathways
9.9NCSTN, PSENEN
3
Show member pathways
Notch signaling pathway36
9.9NCSTN, PSENEN
49.8PSENEN, PSEN1
5
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.5NCSTN, PSENEN, PSEN1
6
Show member pathways
Alzheimers Disease36
9.5NCSTN, PSENEN, PSEN1
79.5NCSTN, PSENEN, PSEN1
89.5NCSTN, PSENEN, PSEN1
99.5PSEN1, PSENEN, NCSTN
109.5PSEN1, PSENEN, NCSTN
119.5PSEN1, PSENEN, NCSTN
129.5PSEN1, PSENEN, NCSTN
13
Show member pathways
9.5PSEN1, PSENEN, NCSTN
14
Show member pathways
Development Notch Signaling Pathway58
Transcription Sin3 and NuRD in transcription regulation58
9.0PSEN1, PSENEN, IL1A, NCSTN
15
Show member pathways
8.8TLR2, DEFB1, DEFB4A
16
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.7IL1A, TLR2, DEFB4A
17
Show member pathways
8.5TLR2, PSEN1, IL1A, NCSTN

Compounds for genes affiliated with Acne

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Compounds related to Acne according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1dapt5910.2PSENEN, PSEN1
2begacestat5910.2PSEN1, PSENEN
3jlk 65910.2PSEN1, PSENEN
4l-685,4585910.2PSENEN, PSEN1
5mrk 5605910.2PSENEN, PSEN1
617-hydroxypregnenolone439.7CYP21A2, SHBG
711 deoxycortisol439.7CYP21A2, SHBG
8leuprolide acetate439.6CYP21A2, SHBG
9ciprofloxacin43 49 1211.6IL1A, DEFB1
10clomiphene citrate439.6SHBG, CYP21A2
11hcec439.5DEFB4A, TLR2
123-alpha-androstanediol glucuronide43 2410.5SHBG, CYP21A2
13valine439.4PSEN1, RBP4, CYP21A2
14flagellin43 2810.4TLR2, DEFB4A
15dehydroepiandrosterone sulfate439.4CYP21A2, RBP4, SHBG
16androstenedione43 2410.4RBP4, SHBG, CYP21A2
17biotin43 24 1211.3CYP21A2, SHBG, PSEN1
1817-hydroxyprogesterone43 2410.3CYP21A2, SHBG
19thyroxine43 2410.3RBP4, CYP21A2, SHBG
20imiquimod43 59 28 1212.2TLR2, IL1A
21hbd2439.2DEFB4A, DEFB1, TLR2
22nacl439.2DEFB4A, CYP21A2, DEFB1
23ketoconazole43 28 24 1212.2CYP21A2, SHBG, IL1A
24hydrocortisone43 2 59 1212.2SHBG, CYP21A2, IL1A
25polymyxin b439.1TLR2, DEFB1, IL1A
26ascorbic acid43 2410.1SHBG, IL1A, RBP4
27acth439.1CYP21A2, SHBG, IL1A
28ionomycin439.1TLR2, IL1A, PSEN1
29aspartate439.1PSEN1, SHBG, IL1A, RBP4
30endotoxin439.1IL1A, DEFB4A, TLR2
31spironolactone43 59 28 49 1213.0CYP21A2, SHBG
32calcitriol43 59 24 1211.9TLR2, SHBG, IL1A
33norepinephrine43 24 1210.8PSEN1, IL1A, SHBG, CYP21A2
34genistein43 28 59 2 24 1213.8CYP21A2, SHBG, IL1A, DEFB4A
35steroid438.8CYP21A2, DEFB4A, SHBG, RBP4
36testosterone43 59 24 1211.7CYP21A2, SHBG, IL1A, RBP4
37epinephrine43 24 1210.7CYP21A2, SHBG, IL1A
38simvastatin43 49 59 28 24 1213.7RBP4, IL1A, SHBG, TLR2
39rantes438.7IL1A, TLR2, DEFB1, DEFB4A
40leucine438.7CYP21A2, TLR2, RBP4, PSEN1
41ribonucleic acid438.6IL1A, CYP21A2, RBP4, TLR2
42progesterone43 28 59 24 1212.5CYP21A2, DEFB4A, SHBG, IL1A, RBP4
43cycloheximide438.5IL1A, TLR2, PSEN1, CYP21A2
44arginine438.0CYP21A2, PSEN1, SHBG, TLR2, IL1A
45serine437.9CYP21A2, RBP4, IL1A, TLR2, PSTPIP1, PSEN1
46glucose437.8SHBG, RBP4, PSEN1, TLR2, DEFB1, CYP21A2
47cholesterol43 28 24 1210.7RBP4, CYP21A2, TLR2, SHBG, PSEN1, PSENEN
48retinoic acid43 248.5RBP4, DEFB1, DEFB4A, TLR2, IL1A, SHBG
49lipid437.2PSENEN, PSEN1, SHBG, CYP21A2, DEFB4A, RBP4
50dexamethasone43 49 28 1210.2RBP4, TLR2, CYP21A2, SHBG, IL1A, DEFB1

GO Terms for genes affiliated with Acne

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Cellular components related to Acne according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7NCSTN, PSENEN, PSEN1, TLR2
2extracellular regionGO:00055767.9RBP4, IL1A, SHBG, DEFB1, DEFB4A

Biological processes related to Acne according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:005043510.0NCSTN, PSEN1
2membrane protein intracellular domain proteolysisGO:003129310.0PSENEN, NCSTN
3epithelial cell proliferationGO:005067310.0PSEN1, NCSTN
4amyloid precursor protein catabolic processGO:00429879.8NCSTN, PSENEN, PSEN1
5membrane protein ectodomain proteolysisGO:00065099.8PSEN1, PSENEN, NCSTN
6Notch receptor processingGO:00072209.8NCSTN, PSENEN, PSEN1
7protein processingGO:00164859.8PSEN1, PSENEN, NCSTN
8positive regulation of catalytic activityGO:00430859.8NCSTN, PSENEN, PSEN1
9Notch signaling pathwayGO:00072199.7NCSTN, PSENEN, PSEN1
10positive regulation of apoptotic processGO:00430659.4NCSTN, PSENEN, PSEN1
11response to insulinGO:00328689.3RBP4, TLR2
12positive regulation of cytokine secretionGO:00507159.1TLR2, IL1A
13innate immune responseGO:00450878.5PSTPIP1, TLR2, DEFB1, DEFB4A
14inflammatory responseGO:00069548.5IL1A, PSTPIP1, TLR2
15immune responseGO:00069558.5DEFB4A, DEFB1, TLR2, IL1A

Molecular functions related to Acne according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:00041759.8NCSTN, PSEN1

Products for genes affiliated with Acne

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Sources for Acne

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet