Acne malady

MedlinePlus: Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Acne, also known as acne, unspecified (disorder), is related to hidradenitis suppurativa and rosacea. An important gene associated with Acne is ACN9 (ACN9 homolog (S. cerevisiae)), and among its related pathways are Bacterial infections in CF airways and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds estradiol and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, skin and ovary, and related mouse phenotypes are hematopoietic system and craniofacial.

Wikipedia: Acne vulgaris (cystic acne or simply acne) is a common human skin disease, characterized by areas of...⁴⁴ more...

Aliases & Descriptions:

acne 6 23 43 acne, unspecified (disorder) 6

acne, unspecified 6 acne (disorder) 6

Diseases related to acne by text searches and GeneDecks gene sharing:

(show top 50)    (show all 994)

id	Related Disease	Score	Top Affiliating Genes
1	hidradenitis suppurativa	31.9	NCSTN, HSD17B13, TNF, TNFRSF1B, CYP1A1, SRD5A1
2	rosacea	31.7	IL18, IL8, CAMP, EGF, TLR2, SOD1
3	hidradenitis	31.2	NCSTN, HSD17B13, TNF, CYP1A1, SRD5A1, NOD2
4	21-hydroxylase deficiency	30.0	IFNA2, ALPP, KRT8, TIMP1, GGT1
5	familial male-limited precocious puberty	30.0	LEP, IGFBP3, IGF1, CYP21A2, SHBG, PRL
6	sapho syndrome	29.9	HLA-B, TNF, NOD2, PRL
7	arthritis	29.2	IL1A, IL8, TNF, NR4A2, TIMP1
8	pyoderma gangrenosum	29.1	MMP1, IL1R1, IL8, IFNA2, TNF, NOD2
9	pyoderma	29.1	MMP1, IL1R1, IL8, IFNA2, TNF, NOD2
10	polycystic ovary syndrome	28.9	LEP, AR, INS, INSR, IGF1R, IGFBP3
11	acanthoma	28.5	FGFR2, KRT16, KRT1, KRT10
12	creatine phosphokinase	28.2	PIK3C2A, CHKB, ALPP, HSD17B13, SOD1, SLPI
13	alcohol dependence	27.6	LEP, MMP9, IL1A, IL1RN, IGF1, CAT
14	amenorrhea	27.1	BGLAP, LEP, AR, INS, IGFBP3, IGF1
15	adrenal hyperplasia	27.0	BTD, LEP, CD36, AR, INS, IGFBP3
16	acanthosis nigricans	26.8	LEP, INS, INSR, FGFR2, IGF1R, IGF1
17	periodontitis	26.4	MPO, CD209, CD36, MMP1, MMP9, IL1A
18	squamous cell carcinoma of the head and neck	25.8	JUN, MMP1, MMP2, MMP9, IL4, IGF1R
19	hyperandrogenism	25.6	LEP, CD36, AR, INS, INSR, IGF1R
20	sarcoidosis	24.5	PIK3C2A, MMP1, MMP9, GZMB, IL18, IL1A
21	squamous cell carcinoma	24.4	BMP6, LDLR, MT-CO1, MT-CO2, S100A7, XDH
22	sinusitis	23.9	BMP6, BGLAP, MPO, MMP2, MMP9, INS
23	homocysteine	23.1	PIK3C2A, BTD, LEP, LDLR, MT-CO3, XDH
24	dermatitis	22.8	PIK3C2A, BTD, BGLAP, LEP, S100A7, ATP2A2
25	insulin resistance	20.1	BMP6, BGLAP, LEP, CHKB, LDLR, MT-ND3
26	obesity	18.1	PIK3C2A, PCSK9, BMP6, BGLAP, LEP, CHKB
27	carcinoma	15.1	PIK3C2A, PCSK9, BTD, BMP6, USP25, BGLAP
28	androgenetic alopecia	14.2	AR, CYP21A2, SRD5A1, SHBG, STS
29	bowen syndrome	14.1	FLG, KRT16, KRT17, KRT1, KRT10, KRT14
30	keratoderma	14.1	FLG, KRT16, KRT17, KRT1, KRT10, KRT14
31	epidermolysis bullosa simplex	14.1	ATP2A2, FLG, KRT16, KRT17, KRT1, KRT10
32	keratoacanthoma	14.1	MMP1, GZMB, FLG, CRABP2, KRT16, KRT17
33	epidermolytic acanthoma	14.0	KRT16, KRT1, KRT10
34	male pseudohermaphroditism due to defective lh	14.0	AR, ALPP, HSD17B13, CYP17A1, SRD5A1, NR5A1
35	ichthyosis	14.0	FLG, CRABP2, NOD2, KRT16, KRT17, KRT1
36	oral candidiasis	14.0	MPO, DEFB1, DEFB4A, PSTPIP1, SLPI
37	steatocystoma multiplex	14.0	KRT16, KRT17, KRT10
38	palmoplantar keratosis	14.0	KRT16, KRT17, KRT1, KRT10
39	tonsillitis	14.0	DEFB1, DEFB4A, SOD1
40	gonadal dysgenesis	14.0	BGLAP, XDH, CYP21A2, SRD5A1, NR5A1, SHBG
41	micropenis	14.0	AR, IGFBP3, CYP17A1, SRD5A1, NR5A1
42	mayer-rokitansky-kuster-hauser syndrome	14.0	BTD, LDLR, CD36, FLG, APOC2, CBS
43	trichoepithelioma	14.0	MME, KRT8, KRT17, KRT10, KRT14
44	androgen insensitivity syndrome, partial	14.0	AR, SRD5A1, SHBG
45	epidermolytic palmoplantar keratoderma	14.0	KRT16, KRT17, KRT1
46	hypospadias	13.9	AR, FGFR2, ESR1, CYP1A1, CYP17A1, CYP21A2
47	basal cell carcinoma	13.9	S100A7, MME, MMP1, GZMB, CYP1A1, CRABP2
48	bronchitis	13.9	LEP, CHKB, ANPEP, ALOX5, CAMP, CYP1A1
49	epidermolytic hyperkeratosis	13.9	FLG, KRT16, KRT1, KRT10
50	giant cell hepatitis	13.9	CYP1A1, CYP17A1, CYP21A2, GGT1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acne:

²²

MGI Mouse Phenotypes related to acne:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.7	CMAHP, UNG, ZC3H12A, GZMB, IREB2, FLG
2	craniofacial phenotype	MP:0005382	10.4	KRT10, SHARPIN, TTN, DSC1, PSEN1, CSF1
3	endocrine/exocrine gland phenotype	MP:0005379	10.3	GGT1, PSEN1, DPP4, TLR2, NR5A1, IFNG
4	embryogenesis phenotype	MP:0005380	9.9	KRT8, EGFR, G6PD, TTN, TFAP2A, PSEN1
5	pigmentation phenotype	MP:0001186	9.8	GGT1, POMC, TFAP2A, TLR4, KRT14, KRT1
6	hearing/vestibular/ear phenotype	MP:0005377	9.5	CRABP2, KRT10, EGFR, TLR4, TFAP2A, SOD1
7	liver/biliary system phenotype	MP:0005370	9.4	IL22, IFNG, CBS, HSPG2, TNFAIP3, NR5A2
8	no phenotypic analysis	MP:0003012	9.3	CYP1A1, CYP26A1, EGFR, POMC, RORC, ADARB1
9	limbs/digits/tail phenotype	MP:0005371	9.2	CRABP2, KRT10, EGFR, TLR4, TFAP2A, PSEN1
10	integument phenotype	MP:0010771	9.0	BTD, LDLR, XDH, ATP2A2, MME, FLG
11	normal phenotype	MP:0002873	8.9	NR5A1, CRH, SHARPIN, ACO1, HIF1A, TTN
12	reproductive system phenotype	MP:0005389	8.8	KRT14, KRT8, NR5A2, NR5A1, SHARPIN, TLR4
13	skeleton phenotype	MP:0005390	8.8	RASGRP4, LEP, JUN, MMP2, MMP9, IREB2
14	mortality/aging	MP:0010768	8.6	PIK3C2A, NCSTN, CMAHP, UNG, ZC3H12A, LEP
15	immune system phenotype	MP:0005387	8.3	GZMB, IREB2, FLG, FGFR2, ANPEP, IGF1R
16	growth/size phenotype	MP:0005378	8.0	PPARA, PSEN1, RORA, RORB, RORC, ADARB1
17	tumorigenesis	MP:0002006	7.9	KRT10, TNFRSF1B, TNF, ESR1, HP, CAT
18	vision/eye phenotype	MP:0005391	7.0	NCSTN, BTD, LEP, LDLR, MT-ND6, TNFRSF1B
19	digestive/alimentary phenotype	MP:0005381	INF	CD36, NOD2, KRT8, KRT16, KRT17, KRT14
20	homeostasis/metabolism phenotype	MP:0005376	INF	SOD1, SORT1, CSF1, POMC, SLPI, RORA
21	respiratory system phenotype	MP:0005388	INF	RORA, PSEN1, SHARPIN, CRH, CBS, APOE
22	renal/urinary system phenotype	MP:0005367	INF	TNFAIP3, TNFRSF1B, CYP26A1, EGFR, HIF1A, PSEN1
23	adipose tissue phenotype	MP:0005375	INF	IGFBP3, IGF1, ALOX5, ESR1, TNF, TNFRSF1B
24	nervous system phenotype	MP:0003631	INF	NR5A1, CRH, EGFR, G6PD, HIF1A, TLR2
25	muscle phenotype	MP:0005369	INF	MMP9, AR, , FGFR2, IL18, IL1R1
26	behavior/neurological phenotype	MP:0005386	INF	TTN, KRT16, NR5A1, NR4A2, CYP17A1, TNFRSF1B
27	cardiovascular system phenotype	MP:0005385	INF	CYP26A1, RORA, POMC, CSF1, PPARA, NR5A1
28	cellular phenotype	MP:0005384	INF	G6PD, LY96, RORC, HIF1A, TTN, TLR2

Articles related to acne:

(show top 50)    (show all 144)

id	Title	Authors	Year	Affiliating Genes
1	Deficiency of IL-22 contributes to a chronic inflamma tory disease: pathogenetic mechanisms in acne inversa. (21148041)	Wolk K.... Sabat R.	2011	IL22
2	TNFR 2 M196R polymorphism and acne vulgaris in Han Ch inese: a case-control study. (20556591)	Tian L.... Wang W.	2010	TNFRSF10A
3	Association Study of Tumor Necrosis Factor Receptor T ype 2 M196R and Toll-Like Receptor 2 Arg753Gln Polymorphisms with Acne Vulgaris in a Chinese Han Ethnic Group. (20861605)	Tian L.M.... Wang W.Z.	2010	TNFRSF1B, TLR2
4	Role of insulin, insulin-like growth factor-1, hyperg lycaemic food and milk consumption in the pathogenesis of acne vulgaris. (19709092)	Melnik B.C.... Schmitz G.	2009	IGF1, INS
5	Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines. (18704103)	Shibata M.... Tagami H.	2009	TLR2
6	Human beta-defensin-2 and psoriasin are overexpressed in lesions of acne inversa. (19249126)	Schlapbach C.... Hunger R.E.	2009	S100A7, DEFB4A
7	Aczone, a topical gel formulation of the antibacterial, anti-inflammatory dapsone for the treatment of acne. (19431080)	Scheinfeld N.	2009	G6PD
8	Relationship between the CAG Repeat Polymorphism in the Androgen Receptor Gene and Acne in the Han Ethnic Group. (19218788)	Yang Z.... He L.	2009	AR
9	In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402. (19775376)	Witter K.... Kauke T.	2009	HLA-DPB1
10	Anti-acne agents attenuate FGFR2 signal transduction in acne. (19225542)	Melnik B.C.... Zouboulis C.C.	2009	FGFR2
11	Lack of association between the promoter polymorphism s at positions -238 and -308 of the tumour necrosis factor alpha gene and acne vulgaris in Polish patients. (18624881)	Sobjanek M.... WA8odarkiewicz A.	2009	TNF
12	Pyogenic arthritis, pyoderma gangrenosum, and acne sy ndrome (PAPA syndrome): report of a sporadic case without an identifiable mutat ion in the CD2BP1 gene. (19700023)	Hong J.B.... Chiu H.C.	2009	PSTPIP1
13	Plasma homocysteine level is elevated in patients on isotretinoin therapy for cystic acne: a prospective controlled study. (18608712)	Polat M.... Alli N.	2008	CBS
14	Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. (18200058)	Lee D.Y.... Gallo R.L.	2008	CAMP
15	Concentration of selected cytokines in serum of patients with acne rosacea (19140384)	Salamon M.... Wozniacka A.	2008	IL18
16	Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris. (18463682)	Nakatsuji T.... Huang C.M.	2008	IL8
17	Hematologic safety of dapsone gel, 5%, for topical tr eatment of acne vulgaris. (19075138)	Piette W.W.... Wilson D.	2008	G6PD, HP
18	TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. (17033191)	Koreck A.... Szell M.	2006	TLR2
19	Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. (16528362)	Trivedi N.R.... Thiboutot D.M.	2006	MMP1, GZMB
20	Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. (16205063)	Kim J.	2005	TLR1, TLR2, TLR6
21	Modulation of androgen receptor transcriptional activity by anti-acne reagents. (15519139)	Inui S.... Itami S.	2004	AR, TGFB1I1
22	A systemic type I 5 alpha-reductase inhibitor is inef fective in the treatment of acne vulgaris. (14988688)	Leyden J.... Waldstreicher J.	2004	SRD5A1
23	Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. (15030323)	Graham G.M.... Ingham E.	2004	CSF1
24	Isotretinoin treatment of acne in a patient with Apert syndrome. (14521567)	Gilaberte M.... Alomar A.	2003	FGFR2
25	Treatment with Propionibacterium acnes modulates the late phase reaction of immediate hypersensitivity in mice. (12880687)	Braga E.G.... Longo-MaugAcri I.M.	2003	IL4
26	Defensins and acne. (14568392)	Philpott M.P.	2003	DEFB1, DEFB4A
27	A randomized controlled trial of second- versus third-generation oral contraceptives in the treatment of acne vulgaris. (12748463)	Rosen M.P.... Nagamani M.	2003	SHBG
28	The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defence system in papulopustular acne. (11809596)	Basak P.Y.... Delibas N.	2002	SOD1, CAT
29	The association of serum androsterone glucuronide with inflammatory lesions in women with adult acne. (12398233)	Carmina E.... Lobo R.A.	2002	SRD5A1
30	Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. (11277950)	Schulpis K.H.... Tsakiris S.	2001	CBS, BTD
31	Exploration of retinoid activity and the role of infl ammation in acne: issues affecting future directions for acne therapy. (11843237)	Zouboulis C.C.	2001	CYP1A1
32	Clinical significance of markedly elevated serum crea tine kinase levels in patients with acne on isotretinoin. (11800143)	Landau M.... Nevo Y.	2001	CHKB
33	The role of the antioxidative defense system in papulopustular acne. (11349462)	Basak P.Y.... Kilinc I.	2001	SOD1, CAT
34	Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. (11710922)	Chronnell C.M.... MA1ller-RAPver S.	2001	DEFB1, DEFB4A
35	The role of androgens in determining acne severity in adult women. (10951152)	Cibula D.... Zivny J.	2000	SHBG
36	Is acne an infection of blocked pilosebaceous follicles? Implications for antimicrobial treatment. (11702364)	Eady E.A.... Cove J.H.	2000	IL1A
37	Tretinoin-iontophoresis in atrophic acne scars. (10192170)	Schmidt J.B.... Reiner A.	1999	CD36
38	Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. (10584414)	Wang H.S.... Soong Y.K.	1999	SHBG
39	Forms of epithelial differentiation of draining sinus in acne inversa (hidradenitis suppurativa). (10468793)	Kurzen H.... Moll R.	1999	DSG2, DSC2, KRT10
40	Do some men with acne vulgaris have raised levels of LH? (10435067)	Farrell A.... Cream J.J.	1999	SHBG
41	Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris. (9557222)	Thiboutot D.... Lin G.	1998	SRD5A1, HSD17B13
42	Carrier status for steroid 21-hydroxylase deficiency is only one factor in the variable phenotype of acne. (9579234)	Ostlere L.S.... Honour J.W.	1998	CYP21A2
43	Isotretinoin, tetracycline and circulating hormones i n acne. (9298137)	Palatsi R.... Oikarinen A.	1997	SRD5A1
44	Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. (7608381)	Aizawa H.... Niimura M.	1995	IGF1
45	Raised serum 11-deoxycortisol in men with persistent acne vulgaris. (7586599)	Ramsay B.... Cream J.J.	1995	SHBG
46	Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline. (1357852)	Akamatsu H.... Niwa Y.	1992	XDH
47	Isotretinoin treatment alters steroid metabolism in w omen with acne. (1827343)	Rademaker M.... Simpson N.B.	1991	SRD5A1
48	Intrascrotal and seminal vesicular granuloma probably induced by propionibacterium acnes (1755428)	Yamamoto S.... Yoshida O.	1991	CRP
49	Late onset adrenal hyperplasia in a group of Irish females who presented with hirsutism, irregular menses and/or cystic acne. (2139596)	McLaughlin B.... Devlin J.G.	1990	CYP21A2
50	Steroid sulfatase activity in epidermis of acne-prone and non-acne-prone skin of patients with acne vulgaris. (2145810)	Milewich L.... Herndon J.H.	1990	STS

Genes related to acne according to GeneCards:

(show top 50)    (show all 156)

id	Symbol	Description	Score	GeneCards Section Context
1	ACN9	ACN9 homolog (S. cerevisiae)	11.1	Domains & Families, Aliases & Descriptions, Gene, Publications (show all 8 sections) Databases, Transcripts, Orthologs, Proteins
2	ACIN1	apoptotic chromatin condensation inducer 1	11.0	Aliases & Descriptions
3	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	11.0	Publications
4	PSENEN	presenilin enhancer 2 homolog (C. elegans)	11.0	Publications
5	NCSTN	nicastrin	11.0	Publications
6	PSEN1	presenilin 1	11.0	Publications
7	DEFB1	defensin, beta 1	11.0	Publications
8	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
9	DEFB4A	defensin, beta 4A	11.0	Publications
10	SHBG	sex hormone-binding globulin	11.0	Publications
11	TLR2	toll-like receptor 2	11.0	Publications
12	BTD	biotinidase	11.0	Publications
13	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
14	IL1A	interleukin 1, alpha	11.0	Publications
15	PPARA	peroxisome proliferator-activated receptor alpha	11.0	Publications
16	DUX4L14	double homeobox 4 like 14	10.9
17	DUX4L2	double homeobox 4 like 2	10.9
18	FOXD4L2	forkhead box D4-like 2	10.9	Databases
19	RASGRP4	RAS guanyl releasing protein 4	10.9
20	ODF3	outer dense fiber of sperm tails 3	10.9
21	TNFAIP3	tumor necrosis factor, alpha-induced protein 3	10.9
22	DNAAF2	dynein, axonemal, assembly factor 2	10.9
23	HAS3	hyaluronan synthase 3	10.9
24	APOL6	apolipoprotein L, 6	10.9
25	ZC3H12A	zinc finger CCCH-type containing 12A	10.9
26	B3GALT4	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	10.9
27	DNASE2	deoxyribonuclease II, lysosomal	10.9
28	SHARPIN	SHANK-associated RH domain interactor	10.9
29	SKA2	spindle and kinetochore associated complex subunit 2	10.9
30	TGFB1I1	transforming growth factor beta 1 induced transcript 1	10.9	Publications
31	S100A7	S100 calcium binding protein A7	10.9	Publications
32	RSL24D1	ribosomal L24 domain containing 1	10.9	Databases
33	CLEC4D	C-type lectin domain family 4, member D	10.9	Publications
34	IL22	interleukin 22	10.9	Publications
35	DSC1	desmocollin 1	10.9	Publications
36	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	10.9	Publications
37	DSC2	desmocollin 2	10.9	Publications
38	KRT17	keratin 17	10.9	Publications
39	KRT16	keratin 16	10.9	Publications
40	NR4A2	nuclear receptor subfamily 4, group A, member 2	10.9
41	FRMD7	FERM domain containing 7	10.9
42	FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	10.9
43	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	10.9	Publications
44	B4GALT4	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	10.9
45	TLR1	toll-like receptor 1	10.9	Publications
46	RORC	RAR-related orphan receptor C	10.9	Orthologs
47	CREB3	cAMP responsive element binding protein 3	10.9
48	ALDH4A1	aldehyde dehydrogenase 4 family, member A1	10.9
49	TLR6	toll-like receptor 6	10.9	Publications
50	STS	steroid sulfatase (microsomal), isozyme S	10.9	Publications

Pathways related to acne according to GeneDecks:

(show top 50)    (show all 108)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.9	LY96, TLR2, DEFB4A, IL1R1, TLR1
2	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.6	TLR1, TLR6, JUN, LY96
3	Graft-versus-host disease20	10.6	HLA-DPB1, IL1A, HLA-C, HLA-A, HLA-B
4	RAR-Gamma-RXR-Alpha Degradation36	10.5	CSF1, IL22, TBP, CRABP2
5	Immune response_Bacterial infections in normal airways41	10.5	IFNG, TLR1, IL1R1, LY96, DEFB4A
6	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.4	TLR1, TLR2, TLR4, IL4, IL22, IFNG
7	Toll-Like Receptor Signaling Pathways37	10.3	CD36, IL18, TLR2, TLR6, LY96, TLR4
8	NOD-like receptor signaling pathway20	10.2	IL18, PSTPIP1, NOD2, NOD1, TNFAIP3, TNF
9	Immune response_TLR signaling pathways41	10.2	IL8, LY96, TLR6, TLR4, TLR2, IL4
10	TRAF Pathway36	10.2	IL1A, JUN, IL1R1, TNF, TNFRSF1B, TLR1
11	Tuberculosis20	10.2	HLA-DPB1, IL1A, IFNG, TLR4, IL18, CD209
12	Akt Signaling36	10.1	TNF, CCL2, IL4, IL22, IL18, TNFRSF10A
13	Th1 Differentiation37	10.1	TLR6, TLR2, TLR1, TNF, IFNG, IL18
14	MIF Mediated Glucocorticoid Regulation36	10.0	IL8, IL4, CCL2, TNF, TLR4, CSF1
15	Type I diabetes mellitus20	9.9	TNF, GZMB, INS, HLA-DPB1, HLA-C, HLA-B
16	all-trans-Retinoic Acid Signaling in Brain36	9.9	BMP6, CRABP2, CSF1, IL22, IL18, IL1A
17	Glucocorticoid Receptor Signaling36	9.9	IL1A, IL1R1, IL22, IL4, CCL2, TNFRSF10A
18	NF-KappaB (p50-p65) Pathway36	9.9	BMP6, TNF, TNFAIP3, TNFRSF1B, EGF, EGFR
19	Allograft rejection20	9.9	HLA-DPB1, TNF, IL4, IFNG, HLA-A, HLA-C
20	Toll-like receptor signaling pathway20	9.9	TNF, JUN, IL8, IFNA2, TLR1, TLR4
21	Malaria20	9.8	CD36, IL18, IL8, TNF, TLR2, CCL2
22	Cytokine Network36	9.8	IFNA2, IL8, IL1A, IL4, TNF, IFNG
23	NF-KappaB Family Pathway36	9.8	BMP6, EGF, TNF, TIMP1, TLR2, IL1R1
24	MIF Regulation of Innate Immune Cells36	9.8	LY96, CSF1, TLR4, CCL2, IL8, IL4
25	Rheumatoid arthritis20	9.8	CSF1, JUN, IL18, MMP1, IL1A, IL8
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.7	BGLAP, IL1A, IGF1, TNF, JUN, AR
27	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.7	AR, IFNG, BGLAP, JUN, TNF, APOE
28	Cell adhesion ECM remodeling10	9.5	IGF1R, MMP1, MMP2, MMP9, IL8, IGF1
29	Cell adhesion_ECM remodeling41	9.5	IL8, EGFR, IGF1, IGF1R, MMP9, MMP2
30	Colorectal Cancer Metastasis36	9.4	EGF, MMP1, MMP9, TLR2, TLR1, TLR6
31	TGF-Beta Pathway36	9.2	JUN, EGFR, BMP6, IGF1, TNFRSF10A, TNFRSF1B
32	STAT3 Pathway36	9.2	IL1R1, IL4, IL8, CSF1, CCL2, TNFRSF10A
33	Influenza A20	9.2	IFNG, IFNA2, CCL2, IL8, IL18, JUN
34	MAPK Family Pathway36	9.1	IL22, IL1A, IL1R1, CCL2, IGF1, TNFRSF1B
35	PAK Pathway36	9.0	BMP6, CSF1, TIMP1, EGFR, TNF, IGF1
36	Cytokine-cytokine receptor interaction20	9.0	IL4, PRL, TNFRSF10A, CSF1, EGFR, EGF
37	Antioxidant Action of Vitamin-C36	8.9	IL1A, IL4, IL22, IL1R1, IL18, JUN
38	Alzheimers disease20	8.5	TNF, MT-CO1, MT-ATP8, ATP2A2, MME, APOE
39	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.38	5.9	MT-ND3, MT-ATP8, MT-ND1, MT-ND5, MT-ND2, MT-CO3
40	Parkinsons disease20	5.8	MT-ND3, MT-CO1, MT-CO2, MT-ND4, MT-CO3, MT-ND1
41	Oxidative phosphorylation20	5.8	MT-ND6, MT-ND5, MT-ND4L, MT-ND3, MT-CO1, MT-CO2
42	Metabolic pathways20	5.5	MT-ND4, MT-CO2, MT-ND3, CYP17A1, CYP21A2, ABO
43	PGC1Alpha Pathway36	INF	IL4, IL18, CREB3, PPARA, TNFRSF1B, TNFRSF10A
44	ERK Signaling36	INF	FGFR2, IL4, IGF1R, BMP6, HSPG2, TIMP1
45	Rho Family GTPases36	INF	CSF1, BMP6, JUN, IL8, FGFR2, IL18
46	p38 Signaling36	INF	IL8, IGF1R, IGF1, TNF, TNFRSF10A, TNFRSF1B
47	Tec Kinases Signaling36	INF	TLR2, TLR1, EGFR, TLR4, TNFRSF1B, TNFRSF10A
48	Molecular Mechanisms of Cancer36	INF	FGFR2, TNFRSF10A, , PSEN1, HIF1A, EGFR
49	JAK-STAT Pathway36	INF	F2R, IL18, FGFR2, , JUN, BMP6
50	Endothelin-1 Signaling Pathway36	INF	IGF1R, , FGFR2, IL18, IL1A, BMP6

Compounds related to acne according to GeneDecks:

(show top 50)    (show all 517)

id	Compound	Score	Top Affiliating Genes
1	estradiol32 9 18 9	13.1	CHKB, AR, IL18, IL1R1, HSD17B13, ESR1
2	endotoxin32	10.0	CHKB, IL18, IL1R1, IL1RAPL2, CAMP, HP
3	calcitriol32 42 9 18 9	13.7	BMP6, BGLAP, JUN, CD36, FLG, AR
4	corticosterone32 18	10.7	BGLAP, MPO, IL1A, IL1R1, IL1RAPL2, IL1RN
5	calcium32 9 18 9	12.5	PIK3C2A, PCSK9, BGLAP, CHKB, S100A7, MPO
6	12-o-tetradecanoylphorbol 13-acetate32	9.4	BMP6, MME, MMP2, MMP9, GZMB, FGFR2
7	sulfasalazine32 9 9	11.3	MPO, IL1A, IL1R1, IL1RAPL2, IL1RN, CCL2
8	superoxide32 18	10.1	PIK3C2A, UNG, CHKB, XDH, MPO, MME
9	n acetylcysteine32	9.1	MMP1, MMP2, MMP9, AR, FGFR2, IL18
10	histamine32 18	10.1	BMP6, BGLAP, MPO, MME, IL18, IL1RAPL2
11	polymyxin b32	9.1	LDLR, IL1A, IL1RN, IL4, IL8, CCL2
12	glucose32	9.0	BTD, MT-CO1, MT-ND4, MT-CO3, MT-ND1, MME
13	atorvastatin32 34 9 18 9	13.0	PIK3C2A, BMP6, CHKB, LDLR, MMP1, MMP2
14	nitric oxide32 9 18 9	12.0	BMP6, CHKB, ATP2A2, MPO, MME, GZMB
15	il 1032	8.9	BMP6, IL18, IL1A, IL1R1, IL1RAPL2, IL1RN
16	neopterin32	8.9	CHKB, GZMB, IL18, IL1A, IL1R1, IL1RAPL2
17	retinoid32	8.8	BMP6, JUN, MMP1, FLG, AR, APOE
18	tacrolimus32 34 9 9	11.8	BMP6, CHKB, ATP2A2, CD36, GZMB, INS
19	oxygen32 18	9.8	PIK3C2A, CHKB, MT-CO1, MT-ND2, S100A7, ATP2A2
20	butyrate32	8.7	BMP6, LEP, MPO, JUN, MMP9, IL18
21	arginine32	8.6	PIK3C2A, BTD, BGLAP, LEP, CHKB, LDLR
22	methotrexate32 34 42 9 9	12.6	PIK3C2A, BMP6, LEP, CHKB, MMP1, MMP2
23	cisplatin32 34 9 9	11.6	PIK3C2A, BMP6, BGLAP, UNG, LEP, XDH
24	cholesterol32 9 18 9	11.5	PIK3C2A, NCSTN, PCSK9, LEP, CHKB, LDLR
25	norepinephrine32 9 18 9	11.5	PIK3C2A, BMP6, LEP, CHKB, ATP2A2, MMP1
26	alpha tocopherol32	8.5	BGLAP, LEP, CHKB, LDLR, XDH, CD36
27	adenylate32	8.4	CHKB, LDLR, MME, MMP9, AR, FGFR2
28	simvastatin32 34 42 9 18 9	13.4	PIK3C2A, BMP6, BGLAP, CHKB, LDLR, MMP9
29	ribonucleic acid32	8.4	BMP6, MT-CO1, ATP2A2, MME, MMP1, MMP2
30	paraffin32	7.9	BGLAP, LEP, CHKB, MPO, CD36, MME
31	indomethacin32 9 9	9.8	BMP6, LEP, LDLR, MPO, MME, MMP1
32	cyclosporin a32 42	8.5	PIK3C2A, BMP6, BGLAP, LEP, CHKB, LDLR
33	retinoic acid32 42 18	8.8	BMP6, BGLAP, LDLR, S100A7, MPO, JUN
34	lactate32	6.6	PIK3C2A, BTD, BMP6, CHKB, MT-CO2, MT-ND4
35	citrate32	INF	PIK3C2A, CHKB, MT-CO1, MT-CO2, MT-CO3, MME
36	rosiglitazone32 9 18 9	INF	JUN, CD36, MMP1, MMP2, MMP9, INS
37	glutamate32	INF	BMP6, LEP, LDLR, MME, MMP2, MMP9
38	hydrocortisone32 9 9	INF	BMP6, BGLAP, CD36, MMP1, MMP2, INS
39	herbimycin a32 42	INF	BMP6, JUN, CD36, MMP1, MMP2, MMP9
40	actinomycin d32	INF	LDLR, JUN, MME, MMP9, IREB2, AR
41	genistein32 9 18 9	INF	LDLR, JUN, CD36, MMP1, MMP2, MMP9
42	thyroxine32 18	INF	PIK3C2A, BGLAP, LEP, CHKB, LDLR, INS
43	cysteine32	INF	BTD, BGLAP, CHKB, LDLR, XDH, MMP1
44	estrogen32	INF	BGLAP, LEP, CHKB, S100A7, CD36, MMP1
45	chloroquine32 34 9 9	INF	BMP6, LDLR, , IL18, IL1R1, IL1RN
46	sb 20358032 42	INF	BMP6, BGLAP, CD36, MMP1, MMP2, MMP9
47	dexamethasone32 42 34 9 9	INF	BMP6, BGLAP, LEP, CHKB, LDLR, JUN
48	dihydrotestosterone32 9 18 9	INF	BMP6, BGLAP, LEP, CHKB, AR,
49	lipid32	INF	PIK3C2A, NCSTN, PCSK9, LEP, LDLR, MT-ND2
50	valine32	INF	MT-ND5, MT-ND4, MT-ND1, MT-ND2, MT-ND6, MPO

Cellular components related to acne according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.2	KRT14, KRT10, KRT1, KRT17, KRT16, KRT8
2	phagocytic vesicle membrane	GO:030670	10.1	TLR6, TLR1, HLA-C, HLA-B, HLA-A
3	Golgi apparatus	GO:005794	10.0	CREB3, ACO1, DPP4, TFAP2A, STS, PSEN1
4	cell surface	GO:009986	9.9	TNF, NOD2, TLR2, DPP4, SORT1, ALPP
5	external side of plasma membrane	GO:009897	9.5	TLR2, TNF, IFNG, ANPEP, IL4, CD36
6	extracellular region	GO:005576	7.4	SLPI, POMC, SOD1, PRL, DEFB4A, DEFB1
7	extracellular space	GO:005615	7.1	LY96, IL22, IL1RN, IL1A, IL18, INS
8	plasma membrane	GO:005886	INF	DSC1, TLR6, TLR4, TLR2, TLR1, EGFR
9	membrane	GO:016020	INF	CREB3, KRT1, EGFR, TLR1, DSC1, STS
10	integral to plasma membrane	GO:005887	INF	HLA-B, HLA-C, TNF, TLR1, TLR2, TLR4

Biological processes related to acne according to GeneDecks:

(show top 50)    (show all 59)

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	11.0	STS, KRT14, KRT10, KRT1, KRT17, KRT16
2	intracellular receptor mediated signaling pathway	GO:030522	10.7	RORC, RORB, RORA, NR5A2, NR5A1, NR4A2
3	toll-like receptor signaling pathway	GO:002224	10.6	LY96, TLR6, TLR4, TLR2, TLR1, NOD2
4	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.6	TLR4, TLR2, NOD2, CCL2
5	defense response to bacterium	GO:042742	10.6	DEFB4A, DEFB1, TLR6, TLR4, TLR1, NOD2
6	lipoprotein metabolic process	GO:042157	10.6	PPARA, HSPG2, APOL6, APOE, APOC2, APOC1
7	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.6	TLR4, NOD2, NOD1, TNF, F2R, IL1A
8	toll-like receptor 1 signaling pathway	GO:034130	10.6	LY96, TLR6, TLR4, TLR2, NOD2, NOD1
9	toll-like receptor 2 signaling pathway	GO:034134	10.6	LY96, TLR6, TLR4, TLR2, NOD2, NOD1
10	positive regulation of interleukin-6 production	GO:032755	10.5	TLR4, CD36, IL1A, TNF, NOD1, NOD2
11	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.5	LY96, TLR6, TLR4, TLR2, NOD2, NOD1
12	positive regulation of chemokine production	GO:032722	10.5	TLR4, TLR2, HIF1A, TNF, IL18
13	lipopolysaccharide-mediated signaling pathway	GO:031663	10.5	LY96, TLR4, TLR2, TNF, CCL2, IL18
14	Toll signaling pathway	GO:008063	10.5	LY96, TLR6, TLR4, TLR2, NOD2, NOD1
15	innate immune response	GO:045087	10.4	TLR2, TLR4, TLR6, DEFB1, DEFB4A, PSTPIP1
16	toll-like receptor 4 signaling pathway	GO:034142	10.4	LY96, TLR6, TLR4, TLR2, NOD2, NOD1
17	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.4	TLR6, TLR4, SHARPIN, NOD2, NOD1, TNF
18	transcription initiation from RNA polymerase II promoter	GO:006367	10.4	RORC, RORB, RORA, NR5A2, NR5A1, NR4A2
19	positive regulation of tumor necrosis factor production	GO:032760	10.3	IL18, IFNG, NOD1, NOD2, TLR2, TLR4
20	negative regulation of growth of symbiont in host	GO:044130	10.3	TLR2, TNF, CAMP, IFNG, CD36
21	positive regulation of monocyte differentiation	GO:045657	10.3	JUN, ACIN1, CSF1
22	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.2	TLR4, TLR2, NOD2, NOD1, TNF, CAT
23	defense response to Gram-positive bacterium	GO:050830	10.2	TLR2, NOD1, TNF, CAMP, CD36
24	detection of bacterium	GO:016045	10.2	NOD2, NOD1, HLA-B, HLA-A
25	cellular response to lipopolysaccharide	GO:071222	10.1	TLR4, CYP17A1, TNFRSF1B, TNFAIP3, IFNG, CCL2
26	response to hyperoxia	GO:055093	10.1	MMP9, IL18, ALOX5, CAT
27	cholesterol metabolic process	GO:008203	10.1	CAT, APOE, APOC1, IL4, LDLR, LEP
28	lipid metabolic process	GO:006629	10.1	G6PD, PPARA, HSPG2, APOE, APOC2, APOC1
29	inflammatory response	GO:006954	10.0	BMP6, CRH, CRP, NOD1, TLR1, TLR2
30	positive regulation of nitric-oxide synthase activity	GO:051000	10.0	HIF1A, ESR1, APOE, INS
31	anti-apoptosis	GO:006916	10.0	SOD1, PSEN1, TNFAIP3, TNF, IGF1, IGF1R
32	immune response	GO:006955	9.9	HLA-C, TLR1, TLR2, TLR4, TLR6, DEFB1
33	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.9	TNFRSF1B, TNF, IFNG, APOE
34	angiogenesis	GO:001525	9.8	ANPEP, CCL2, HSPG2, EGF, HIF1A, IL8
35	response to hypoxia	GO:001666	9.8	PPARA, CRP, HIF1A, TLR4, DPP4, TNF
36	positive regulation of transcription, DNA-dependent	GO:045893	9.7	CREB3, EGF, HIF1A, TGFB1I1, TFAP2A, RORB
37	positive regulation of neuron apoptotic process	GO:043525	9.7	TFAP2A, TNF, IL18, JUN, PCSK9
38	small molecule metabolic process	GO:044281	9.5	CYP1A1, CYP26A1, CYP17A1, CYP21A2, SRD5A1, PPARA
39	response to drug	GO:042493	9.3	IFNG, TNF, CYP17A1, SRD5A1, SOD1, CCL2
40	negative regulation of apoptotic process	GO:043066	9.3	SORT1, TFAP2A, TIMP1, EGFR, TNF, CAT
41	signal transduction	GO:007165	9.3	EGF, EGFR, HIF1A, TLR1, TLR2, TLR6
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	NR5A1, CREB3, HIF1A, TLR2, TLR4, TFAP2A
43	positive regulation of DNA replication	GO:045740	INF	EGFR, IGF1, IGF1R, , INS, JUN
44	positive regulation of MAPK cascade	GO:043410	INF	F2R, IGF1, IGFBP3, FGFR2, , INS
45	response to activity	GO:014823	INF	BGLAP, , CCL2, TNF, TLR4
46	response to ethanol	GO:045471	INF	SOD1, TLR4, CCL2, IL4, , MMP9
47	positive regulation of glycolysis	GO:045821	INF	HIF1A, IGF1, , INS
48	positive regulation of cell proliferation	GO:008284	INF	EGF, EGFR, TIMP1, DPP4, STS, CSF1
49	positive regulation of mitosis	GO:045840	INF	EGF, TNF, IGF1, IL1A, , INS
50	positive regulation of nitric oxide biosynthetic process	GO:045429	INF	TLR4, TLR2, EGFR, TNF, ESR1, IFNG

Molecular functions related to acne according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide receptor activity	GO:001875	10.4	LY96, TLR4, TLR2
2	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.4	RORC, RORB, RORA, NR5A2, NR5A1, NR4A2
3	steroid hormone receptor activity	GO:003707	10.3	RORC, RORB, RORA, NR5A2, NR5A1, NR4A2
4	protease binding	GO:002020	9.9	DPP4, TTN, TNFAIP3, TNF, IL1R1, INS
5	enzyme binding	GO:019899	9.9	ACIN1, HIF1A, TTN, SORT1, SLPI, EGFR
6	Gram-positive bacterial cell surface binding	GO:051637	9.9	CRP, CD36, TLR2
7	protein homodimerization activity	GO:042803	9.6	NOD1, SHBG, G6PD, DPP4, TFAP2A, SOD1
8	cytokine activity	GO:005125	9.4	CSF1, TNF, IFNG, IFNA2, IL4, IL22
9	protein binding	GO:005515	INF	GGT1, SHARPIN, KRT14, KRT1, KRT17, KRT16