ACNE
MCID: ACN011
MIFTS: 56

Acne (ACNE) malady

Skin diseases category

Summaries for Acne

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Acne is a common skin disease that causes pimples. pimples form when hair follicles under your skin clog up. most pimples form on the face, neck, back, chest, and shoulders. anyone can get acne, but it is common in teenagers and young adults. it is not serious, but it can cause scars. no one knows exactly what causes acne. hormone changes, such as those during the teenage years and pregnancy, probably play a role. there are many myths about what causes acne. chocolate and greasy foods are often blamed, but there is little evidence that foods have much effect on acne in most people. another common myth is that dirty skin causes acne; however, blackheads and pimples are not caused by dirt. stress doesn't cause acne, but stress can make it worse. if you have acne clean your skin gently try not to touch your skin avoid the sun treatments for acne include medicines and creams. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Acne, also known as acne, unspecified, is related to hidradenitis suppurativa and arthritis. An important gene associated with Acne is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. The compounds dexamethasone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and bone.

Wikipedia:63 Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of skin with... more...

Description from OMIM:46 604324

Aliases & Classifications for Acne

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

acne 8 10 33 30 60
acne, unspecified 8


External Ids:

Disease Ontology8 DOID:6543
OMIM46 604324
NCIt39 C27195
ICD1025 L70, L70.9

Related Diseases for Acne

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acne via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa30.9PSENEN, NCSTN
2arthritis30.5IL1A, PSTPIP1, TLR2, PPARA
3psoriasis30.5IL1A, TLR2, PPARA, DEFB4A
4alopecia30.4BTD, SHBG
5skin disease30.3DEFB4A, PPARA, TLR2, IL1A, SRD5A1
6polycystic ovary syndrome30.3SHBG, CYP21A2, SRD5A1, PPARA
7hyperandrogenism30.3SRD5A1, CYP21A2, SHBG
8sarcoidosis30.3IL1A, DEFB4A, DEFB1
9dermatitis30.3IL1A, BTD, PPARA
10androgenic alopecia30.0SHBG, CYP21A2, SRD5A1
11atopic dermatitis30.0DEFB4A, TLR2
12inflammatory bowel disease30.0TLR2
13congenital adrenal hyperplasia29.9CYP21A2, BTD, SRD5A1
14ulcerative colitis29.9DEFB4A, DEFB1, IL1A, TLR2
15periodontitis29.7IL1A, DEFB4A, DEFB1, TLR2
16candidiasis29.7DEFB4A, BTD
17peritonitis29.7TLR2
18klinefelter's syndrome29.7SRD5A1, CYP21A2, SHBG
19rosacea10.7
20hidradenitis10.6
21synovitis10.6
22hyperostosis10.6
23sapho syndrome10.6
24pyoderma10.4
25pyoderma gangrenosum10.4
26osteomyelitis10.4
27folliculitis10.3
28pyogenic arthritis, pyoderma gangrenosum and acne10.3
29acne inversa, familial, 110.2
30frontalis acne10.2
31pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
32pseudotumor cerebri10.1
33cellulitis10.1
34endophthalmitis10.1
35acne inversa, familial, 310.1
36acne inversa, familial, 210.1
3721-hydroxylase deficiency10.1
38keratosis follicularis10.0
39subdural empyema10.0
40psoriatic arthritis10.0
41pityriasis rubra pilaris10.0
42keratosis10.0
43spondyloarthropathy10.0
44squamous cell carcinoma10.0
45uveitis10.0
46dowling-degos disease10.0
47retinol dystrophy, iris coloboma, and comedogenic acne syndrome10.0
48alzheimer's disease10.0PPARA, IL1A, SHBG, NCSTN, PSENEN, PSEN1
49cystic fibrosis10.0DEFB1, BTD, NF2, DEFB4A
50periodontal disease10.0DEFB4A, IL1A, DEFB1, TLR2

Graphical network of the top 20 diseases related to Acne:



Diseases related to acne

Clinical Features for Acne

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Sources:
46OMIM
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Clinical features from OMIM:

604324

Drugs & Therapeutics for Acne

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Acne

Drug clinical trials:

Search ClinicalTrials for Acne

Search NIH Clinical Center for Acne

Search CenterWatch for Acne

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acne cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acne:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Acne:
Skin-derived fibroblasts, PMIDs: 21287562, 23211390, 10805306

Genetic Tests for Acne

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Anatomical Context for Acne

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acne:

32
Skin, Ovary, Bone, Brain, Monocytes, Testes, Salivary gland, Lung, Liver, Colon, T cells

Animal Models for Acne or affiliated genes

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Publications for Acne

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Sources:
50PubMed
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Articles related to Acne:

(show top 50)    (show all 896)
idTitleAuthorsYear
1
Comparative antimicrobial efficacy of Metapex, Metronidazole, BioPure MTAD, Aztreonam on Bacteroides fragilis and Propionibacterium acne. (23956535)
2013
2
What's new in acne and inflammation? (23839203)
2013
3
Side effects of common acne treatments. (23163336)
2013
4
Biochemical markers of oxidative and nitrosative stress in acne vulgaris: correlation with disease activity. (23325743)
2013
5
The effect of genetic polymorphisms of RARA gene on the adverse effects profile of isotretinoin-treated acne patients. (23782583)
2013
6
Complementary, holistic, and integrative medicine: acne. (23378616)
2013
7
Response to the commentaries on the paper: Propionibacterium acnes strain populations in the human skin microbiome associated with acne. (23774528)
2013
8
SAPHO syndrome associated with acne conglobata successfully treated with etanercept. (24189486)
2013
9
Cutaneous hyperandrogenism: role of antiandrogen therapy in acne, hirsutism, and androgenetic alopecia. (24358489)
2013
10
Efficacy and tolerability of fixed-combination acne treatment in adolescents. (23617089)
2013
11
Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms? (23808708)
2013
12
Effects of isotretinoin on serum vitamin E levels in patients with acne. (23414163)
2013
13
Acne vulgaris is associated with intensive pubertal development and altitude of residence--a cross-sectional population-based study on 6,200 boys. (23247617)
2013
14
Enzymatically generated hydrogen peroxide reduces the number of acne lesions in acne vulgaris. (23449126)
2013
15
Transient postnatal secretion of androgen hormones is associated with acne and sebaceous gland hypertrophy in early infancy. (23144469)
2013
16
The efficacy and tolerability of dapsone 5% gel in female vs male patients with facial acne vulgaris: gender as a clinically relevant outcome variable. (23377510)
2012
17
Acne and skin bleaching in LomAc, Togo. (23210949)
2012
18
Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa. (22136668)
2012
19
Segmental acne versus mosaic conditions with acne lesions. (22456681)
2012
20
Management of acne scarring, part II: a comparative review of non-laser-based, minimally invasive approaches. (22849351)
2012
21
Mediterranean diet and familial dysmetabolism as factors influencing the development of acne. (22833557)
2012
22
Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation. (22759266)
2012
23
Efficacy and safety of a ceramide containing moisturizer followed by fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 2.5% gel in the morning in combination with a ceramide containing moisturizer followed by tretinoin 0.05% gel in the evening for the treatment of facial acne vulgaris. (22648223)
2012
24
Gender as a clinically relevant outcome variable in acne: benefits of a fixed combination clindamycin phosphate (1.2%) and benzoyl peroxide (2.5%) aqueous gel. (23377514)
2012
25
"Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome": comment on the article by Zhao et al. (22211732)
2012
26
Triple combination and glycolic peels in post-acne hyperpigmentation. (22557866)
2012
27
Evaluation of the clinical efficacy of fractional radiofrequency microneedle treatment in acne scars and large facial pores. (22487513)
2012
28
In vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris. (22870816)
2012
29
Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of moderate to severe acne vulgaris in Chinese patients. (22971307)
2012
30
Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. (21148041)
2011
31
Puzzles in practice. Syndrome of synovitis, acne, pustulosis, hyperostosis, and osteitis. (19820290)
2009
32
Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism. (19352298)
2009
33
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
34
Acne vulgaris and acne rosacea as part of immune reconstitution disease in HIV-1 infected patients starting antiretroviral therapy. (18574128)
2008
35
A case of discoid lupus erythematosus masquerading as acne. (18311454)
2008
36
Superoxide dismutase and myeloperoxidase activities in polymorphonuclear leukocytes in acne vulgaris. (16001098)
2005
37
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome in a 14-year-old boy: an immunohistochemical study of infiltrating lymphocytes in acneous skin regions. (15906088)
2005
38
Treatment with Propionibacterium acnes modulates the late phase reaction of immediate hypersensitivity in mice. (12880687)
2003
39
Effects of minocycline on the ocular flora of patients with acne rosacea or seborrheic blepharitis. (12883348)
2003
40
The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defence system in papulopustular acne. (11809596)
2002
41
Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. (11277950)
2001
42
Eruptive acne vulgaris with infectious mononucleosis. (10792257)
2000
43
A case report of synovitis, acne, pustulosis, hyperostosis and osteitis syndrome presenting with spondylodiscitis. (10851353)
2000
44
Acute anterior uveitis in a patient with sacroiliitis and acne conglobata. (10501443)
1999
45
Case report. synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. (9161184)
1996
46
The clinical spectrum of the arthropathy associated with hidradenitis suppurativa and acne conglobata. (8496865)
1993
47
Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline. (1357852)
1992
48
Successful treatment of hidradenitis suppurativa and retroauricular acne with etretinate. (1533313)
1992
49
Endocrine parameters in acne vulgaris. (2151388)
1990
50
Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. (128323)
1975

Genetic Variations for Acne

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Expression for genes affiliated with Acne

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acne

Search GEO for disease gene expression data for Acne.

Pathways for genes affiliated with Acne

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems, 59Tocris Bioscience
See all sources

Pathways related to Acne according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9MT-ATP8, IL1A, MT-ND4L, MT-ND3, MT-ND4, PPARA
2
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10.8PPARA, MT-ATP8, MT-ND4, MT-ND4L, MT-ND3, CYP21A2
3
Hide members
10.7PSENEN, NCSTN, PSEN1, PPARA, IL1A
410.7PSEN1, NF2, NCSTN, PSENEN
5
Hide members
10.7TLR2, PSEN1, IL1A, NCSTN
6
Hide members
10.6PSEN1, PSENEN, NCSTN
7
Hide members
10.6PSEN1, PSENEN, NCSTN
810.6PSENEN, NCSTN, PSEN1
910.6PSEN1, NCSTN, PSENEN
1010.6NCSTN, PSENEN, PSEN1
1110.6NCSTN, PSENEN, PSEN1
1210.6NCSTN, PSENEN, PSEN1
1310.6PSENEN, PSEN1, NCSTN
14
Hide members
10.6DEFB1, TLR2, DEFB4A
15
Immune response Bacterial infections in normal airways
Hide members
10.6DEFB4A, IL1A, TLR2
16
Hide members
10.6PSENEN, NCSTN
1710.6PSENEN, PSEN1

Compounds for genes affiliated with Acne

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acne according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.3DEFB1, CYP21A2, SRD5A1, IL1A, SHBG, DEFB4A
2retinoic acid44 2412.3PSEN1, PPARA, DEFB4A, SHBG, IL1A, SRD5A1
3lipid4411.3CYP21A2, SHBG, NCSTN, DEFB4A, PPARA, PSENEN
4serine4411.3MT-ND3, TLR2, PSEN1, PSTPIP1, PPARA, NF2
5cholesterol44 28 11 2414.2TLR2, SHBG, PSEN1, PSENEN, NCSTN, CYP21A2
6arginine4411.2IL1A, PPARA, TLR2, SHBG, BTD, CYP21A2
7genistein44 28 59 2 11 2416.2SRD5A1, DEFB4A, IL1A, CYP21A2, PPARA, SHBG
8progesterone44 59 28 11 2415.2CYP21A2, NF2, SHBG, IL1A, SRD5A1, DEFB4A
9calcitriol44 59 11 2414.1IL1A, SHBG, SRD5A1, PPARA, TLR2
10vitamin d4411.1SRD5A1, TLR2, PPARA, SHBG, IL1A
11norepinephrine44 11 2413.1IL1A, PSEN1, PPARA, CYP21A2, SHBG
12ketoconazole44 28 11 2414.1SRD5A1, IL1A, CYP21A2, SHBG
13glucose4411.1DEFB1, BTD, PSEN1, CYP21A2
14biotin44 11 2413.1PSEN1, SHBG, CYP21A2, BTD
15hbd24411.1DEFB4A, TLR2, DEFB1
16alanine4411.0PSEN1, SHBG, MT-ND3, BTD, TLR2, PPARA
173-alpha-androstanediol glucuronide44 2412.0CYP21A2, SRD5A1, SHBG
1817-hydroxyprogesterone44 2412.0SHBG, SRD5A1, CYP21A2
19isotretinoin44 1112.0SRD5A1, BTD, PPARA
20simvastatin44 49 59 28 11 2416.0TLR2, IL1A, SHBG, PPARA
21polymyxin b4411.0IL1A, DEFB1, TLR2
22spironolactone49 44 59 28 1115.0SRD5A1, CYP21A2, SHBG
23valine4411.0PPARA, CYP21A2, MT-ND4, PSEN1
24mrk 5605911.0PSENEN, PSEN1
25jlk 65911.0PSEN1, PSENEN
26begacestat5911.0PSEN1, PSENEN
27cycloheximide4411.0PPARA, IL1A, PSEN1, TLR2, CYP21A2
28l-685,4585911.0PSENEN, PSEN1
29dapt5910.9PSENEN, PSEN1
30rantes4410.9DEFB1, TLR2, DEFB4A, IL1A
31dehydroepiandrosterone sulfate4410.9SHBG, SRD5A1, CYP21A2
32epitestosterone4410.9SRD5A1, SHBG
33phenytoin44 49 28 1113.9CYP21A2, SRD5A1, SHBG
34formestane4410.9SRD5A1, SHBG
35enterolactone4410.9SHBG, SRD5A1
36ment4410.9SHBG, SRD5A1
37dhea4410.9SRD5A1, CYP21A2, SHBG
38norgestimate44 1111.9SRD5A1, SHBG
39androstenediol4410.9SHBG, SRD5A1
40androstenedione44 2411.8CYP21A2, SRD5A1, SHBG
41nadh44 11 2412.8MT-ND4L, MT-ND3, MT-ATP8, MT-ND4
4217-hydroxypregnenolone4410.8CYP21A2, SHBG
43desogestrel44 1111.8SHBG, SRD5A1
44acarbose44 1111.7PPARA, SHBG
45goserelin44 28 1112.7SHBG, SRD5A1
4611 deoxycortisol4410.6CYP21A2, SHBG
47testosterone44 59 11 2413.6SRD5A1, CYP21A2, SHBG, IL1A, PPARA
48allopregnanolone4410.6SRD5A1, SHBG
49doca4410.6SRD5A1, CYP21A2
50trichloroethylene4410.3SHBG, PPARA

GO Terms for genes affiliated with Acne

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Sources:
16Gene Ontology
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Biological processes related to Acne according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:04298710.9NCSTN, PSENEN, PSEN1
2Notch receptor processingGO:00722010.8NCSTN, PSEN1, PSENEN
3membrane protein ectodomain proteolysisGO:00650910.8PSENEN, NCSTN, PSEN1
4protein processingGO:01648510.8NCSTN, PSENEN, PSEN1
5positive regulation of catalytic activityGO:04308510.8NCSTN, PSENEN, PSEN1
6beta-amyloid metabolic processGO:05043510.7NCSTN, PSEN1
7positive regulation of apoptotic processGO:04306510.7ACIN1, NCSTN, PSENEN, PSEN1
8epithelial cell proliferationGO:05067310.6NCSTN, PSEN1
9Notch signaling pathwayGO:00721910.6PSEN1, NCSTN, PSENEN
10membrane protein intracellular domain proteolysisGO:03129310.5PSENEN, NCSTN
11immune responseGO:00695510.4TLR2, DEFB1, DEFB4A, IL1A

Products for genes affiliated with Acne

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acne

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet