MCID: ACN018
MIFTS: 45

Acne Inversa, Familial, 1 malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acne Inversa, Familial, 1

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Aliases & Descriptions for Acne Inversa, Familial, 1:

Name: Acne Inversa, Familial, 1 51 69 26 12
Hidradenitis Suppurativa 11 47 25 37 38 13 67
Hidradenitis Suppurativa Familial 69 26
Acne Inversa 47 25
Hidradenitis Suppurativa, Familial 67
Hidradenitides, Suppurative 25
 
Suppurative Hidradenitides 25
Hidradenitis, Suppurative 25
Suppurative Hidradenitis 25
Acne Inversa, Familial 11
Acne Inversa Familial 69
Acninv1 69

Characteristics:

HPO:

63
acne inversa, familial, 1:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM51 142690
Disease Ontology11 DOID:2280
ICD1029 L73.2
MeSH38 D017497
MedGen36 C1840560

Summaries for Acne Inversa, Familial, 1

About this section
OMIM:51 Acne inversa is a chronic relapsing inflammatory skin disease characterized by recurrent draining sinuses and... (142690) more...

MalaCards based summary: Acne Inversa, Familial, 1, also known as hidradenitis suppurativa, is related to sinusitis and lymphangioma, and has symptoms including recurrent cutaneous abscess formation, atypical scarring of skin and pruritus. An important gene associated with Acne Inversa, Familial, 1 is NCSTN (Nicastrin), and among its related pathways are 14-3-3 and Regulation of BAD Activity and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include skin and breast.

UniProtKB/Swiss-Prot:69 Acne inversa, familial, 1: A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty.

MedlinePlus:37 Hidradenitis suppurativa (hs) is a chronic skin disease. it can occur in one or multiple areas of your body. hs usually develops in your armpits, groin, and anal area. it causes long-term skin inflammation and can be painful. symptoms include blackheads and red, tender bumps, called abscesses. the abscesses get bigger, break open, and leak pus tunnels that form under the skin between abscesses scarring no one knows what causes hs. it is more common in women, african americans, and people who have had acne. it usually starts after the teenage years. treatments include antibiotics, anti-inflammatory medicines, and sometimes surgery. losing weight or wearing looser clothing may help some patients avoid skin irritation.

Genetics Home Reference:25 Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.

Wikipedia:70 Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic skin disease characterized by... more...

Related Diseases for Acne Inversa, Familial, 1

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Diseases related to Acne Inversa, Familial, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1sinusitis29.9IL1RN, TNF
2lymphangioma29.7IL1RN, TNF
3pyoderma gangrenosum-acne-suppurative hidradenitis syndrome12.0
4hidradenitis11.2
5perifolliculitis capitis abscedens et suffodiens, familial11.1
6acne inversa, familial, 311.1
7acne inversa, familial, 211.1
8acne10.7
9crohn's disease10.4
10cerebral hemorrhage10.4IL1RN, TNFRSF1B
11hemangioma of spleen10.4IL1RN, TNFRSF1B
12uveoparotid fever10.4TNF, TNFRSF1B
13brain stem cancer10.4TNF, TNFRSF1B
14cerebral atherosclerosis10.4TNF, TNFRSF1B
15stone in bladder diverticulum10.4TNF, TNFRSF1B
16vaginal squamous tumor10.4IL1RN, TNFRSF1B
17neuromuscular disease10.4TNF, TNFRSF1B
18night blindness10.4TNF, TNFRSF1B
19lens disease10.4IL1RN, TNFRSF1B
20fetal erythroblastosis10.3TNF, TNFRSF1B
21primary biliary cirrhosis10.3TNF, TNFRSF1B
22salpingitis10.3TNF, TNFRSF1B
23crest syndrome10.3TNF, TNFRSF1B
24warm antibody hemolytic anemia10.3IL1RN, TNF
25non-secretory myeloma10.3IL1RN, TNF
26allergic hypersensitivity disease10.3TNF, TNFRSF1B
27chromosome 9p deletion syndrome10.3TNF, TNFRSF1B
28oral candidiasis10.3IL1RN, TNF
29pyoderma10.3
30pyoderma gangrenosum10.3
31keloids10.3IL1RN, TNF
32nephrosclerosis10.3TNF, TNFRSF1B
33arthritis10.2
34senile cataract10.2IL1RN, TNF
35achilles bursitis10.2TNF, TNFRSF1B
36osmotic diarrhea10.2IL1RN, TNF
37psoriasis10.2
38tibialis tendinitis10.2IL1RN, TNF
39oropharynx cancer10.2PSTPIP1, TNF
40uterine corpus endometrial stromal sarcoma10.2PSTPIP1, TNF
41spondyloarthropathy10.2
42pediatric supratentorial ependymoma10.2IL1RN, TNF
43retroperitoneal fibrosis10.2IL1RN, TNF
44keratitis10.1
45cellulitis10.1
46elephantiasis10.1
47pyloric stenosis, infantile hypertrophic, 210.1PSTPIP1, TNF
48esophagus melanoma10.1IL1RN, TNF
49capillary lymphangioma10.1NCSTN, PSENEN, TNF
50female reproductive system disease10.1NCSTN, PSENEN, TNF

Graphical network of the top 20 diseases related to Acne Inversa, Familial, 1:



Diseases related to acne inversa, familial, 1

Symptoms for Acne Inversa, Familial, 1

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Symptoms by clinical synopsis from OMIM:

142690

Clinical features from OMIM:

142690

Human phenotypes related to Acne Inversa, Familial, 1:

 63 (show all 13)
id Description HPO Frequency HPO Source Accession
1 recurrent cutaneous abscess formation63 hallmark (90%) HP:0100838
2 atypical scarring of skin63 typical (50%) HP:0000987
3 pruritus63 typical (50%) HP:0000989
4 acne63 typical (50%) HP:0001061
5 abnormality of temperature regulation63 typical (50%) HP:0004370
6 hyperhidrosis63 occasional (7.5%) HP:0000975
7 lymphedema63 occasional (7.5%) HP:0001004
8 arthritis63 occasional (7.5%) HP:0001369
9 weight loss63 occasional (7.5%) HP:0001824
10 microcytic anemia63 occasional (7.5%) HP:0001935
11 neoplasm of the skin63 occasional (7.5%) HP:0008069
12 intestinal fistula63 occasional (7.5%) HP:0100819
13 acne inversa63 HP:0040154

UMLS symptoms related to Acne Inversa, Familial, 1:


exanthema, pruritus

Drugs & Therapeutics for Acne Inversa, Familial, 1

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Drugs for Acne Inversa, Familial, 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 61)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AdalimumabapprovedPhase 4, Phase 3, Phase 2478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
2Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 210355
3Antirheumatic AgentsPhase 4, Phase 3, Phase 210627
4Antibiotics, AntitubercularPhase 36972
5Anti-Bacterial AgentsPhase 3, Phase 210884
6
InfliximabapprovedPhase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
7
Ustekinumabapproved, investigationalPhase 282815610-63-0
Synonyms:
 
Stelera
8
Etanerceptapproved, investigationalPhase 2397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
9
Apremilastapproved, investigationalPhase 264608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
10
Ethinyl EstradiolapprovedPhase 271257-63-65991
Synonyms:
17 alpha-Ethinylestradiol
17 alpha-Ethynylestradiol
17 alpha-Ethynyloestradiol
17 alpha-ethinyestradiol
17-Ethinyl-3,17-estradiol
17-Ethinyl-3,17-oestradiol
17-Ethinylestradiol
17-Ethynylestradiol
17-Ethynylestradiol ram
17-Ethynyloestradiol
17-alpha-Ethinyl-17-beta-estradiol
17-alpha-Ethynyl-17-beta-oestradiol
17-alpha-Ethynylestradiol
17-alpha-Ethynylestradiol-17-beta
17-alpha-ethynyl estradiol
17-ethinyl-3,17-estradiol
17-ethinyl-3,17-oestradiol
17-ethinylestradiol
17.alpha.-Ethinyl-17.beta.-estradiol
17.alpha.-Ethinylestradiol
17.alpha.-Ethynyl-17.beta.-oestradiol
17.alpha.-Ethynylestradiol
17.alpha.-Ethynylestradiol-l7.beta.
17.alpha.-Ethynyloestradiol
17.alpha.-Ethynyloestradiol-17.beta.
17a-Ethinyl-17b-estradiol
17a-Ethinylestradiol
17a-Ethynyl-17b-oestradiol
17a-Ethynylestradiol
17a-Ethynylestradiol-l7b
17a-Ethynyloestradiol
17a-Ethynyloestradiol-17b
17alpha-Ethinyl estradiol
17alpha-Ethinylestradiol
17alpha-Ethinylestradiol-17beta
17alpha-Ethynylestradiol
17alpha-Ethynyloestradiol
17alpha-Ethynyloestradiol-17beta
17α-ethynylestradiol
406932-93-2
46263_FLUKA
46263_RIEDEL
57-63-6
77538-56-8
AC-2169
AC1L1LK6
AI3-52941
Aethinyloestradiolum
Aethinyoestradiol
Aethinyoestradiol [German]
Alora
Amenoron
Amenorone
Anovlar
BIDD:ER0162
BRN 2419975
Bio-0610
C07534
CCRIS 286
CHEBI:4903
CHEMBL691
CID5991
CPD000058319
Certostat
Chee-O-Gen
Chee-O-Genf
Cyclosa
D004997
D00554
DB00977
Dicromil
Diognat-E
Diogyn E
Diogyn-E
Diprol
Dyloform
E4876_SIGMA
EE
EE(sub 2)
EE2
EINECS 200-342-2
EO
ETHINYLESTRADIOL
Effik Brand of Ethinyl Estradiol
Ertonyl
Esclim
Esteed
Estigyn
Estinyl
Estinyl (TN)
Eston-E
Estopherol
Estoral
Estoral (Orion)
Estoral (VAN)
Estoral [Orion]
Estoral {[Orion]}
Estorals
Estradiol, Ethinyl
Estradiol, Ethynyl
Estring
Estrogen
Ethidol
Ethinoral
Ethinyl E2
Ethinyl Estradiol Hemihydrate
Ethinyl Estradiol [USP]
 
Ethinyl Estradiol, (8 alpha)-Isomer
Ethinyl Oestradiol Effik
Ethinyl estradiol
Ethinyl estradiol (USP)
Ethinyl-Oestradiol Effik
Ethinyl-Oestranol
Ethinyl-oestranol
Ethinylestradiol
Ethinylestradiol (JP15/INN)
Ethinylestradiol Jenapharm
Ethinylestradiol [INN:BAN:JAN]
Ethinylestradiolum
Ethinylestradiolum [INN-Latin]
Ethinylestriol
Ethinyloestradiol
Ethinyloestradiol [Steroidal oestrogens]
Ethy 11
Ethynyl estradiol
Ethynylestradiol
Ethynylestradiol, Ethinyl Estradiol
Ethynyloestradiol
Eticyclin
Eticyclol
Eticylol
Etinestrol
Etinestryl
Etinilestradiol
Etinilestradiol [INN-Spanish]
Etinilestradiolo
Etinilestradiolo [DCIT]
Etinoestryl
Etistradiol
Etivex
Evra
Feminone
Fempatch
Follicoral
Ginestrene
Gynodiol
Gynolett
HMS2051I19
HSDB 3587
Halodrin
Hemihydrate, Ethinyl Estradiol
Inestra
Innofem
Jenapharm Brand of Ethinyl Estradiol
Jenapharm, Ethinylestradiol
Kolpolyn
LMST02010036
LS-231
Linoral
Lynoral
MLS000028479
MLS000758274
Marvelon
Menolyn
Menostar
Mercilon
Microfollin
Microfollin Forte
MolPort-001-794-636
NCGC00091533-01
NCGC00091533-04
NCGC00091533-05
NCI60_000234
NSC-10973
NSC10973
Neo-Estrone
Nogest-S
Novestrol
OVULEN-21
OVULEN-28
Oradiol
Orestralyn
Orestrayln
Organon Brand of Ethinyl Estradiol
Ortho-Cyclen
Ovex
Oviol
PUBERTAL ETHINYL ESTRADIOL STUDY
Palonyl
Perovex
Primogyn
Primogyn C
Primogyn M
Progynon C
Progynon M
Prosexol
S1625_Selleck
SAM001247008
SGCUT00127
SMR000058319
Schering Brand of Ethinyl Estradiol
Spanestrin
Thiuram E
Thiuranide
UNII-423D2T571U
Vagifem
Varnoline
WLN: L E5 B666TTT&J E1 FQ F1UU1 OQ
Ylestrol
component of Demulen
component of Oracon
component of Ortrel
ethinyl estradiol
ethynyl estradiol
to_000048
11
DrospirenoneapprovedPhase 210267392-87-468873
Synonyms:
(6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,14,15,15a,16-Hexadecahydro-10,13-dimethylspiro-(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione
1, 2-Dihydrospirorenone
1,2-Dihydrospirorenone
1,2-dihydro-spirorenone
15,16]-17alpha-pregn-4-ene-21,17-carbolactone
15-beta,16-beta-Dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone
15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
17-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone
3-oxo-6alpha,7alpha,15alpha,16alpha-tetrahydro-7'H,16'H-dicyclopropa[6,7
6-beta,7-beta
67392-87-4
6beta,7Beta
6beta,7beta
6beta,7beta,15beta,16beta-dimethylen-3-oxo-17alpha-pregn-4-en-21,17-carbolacton
6beta,7beta,15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17 carbolactone
6β,7β,15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17 carbolactone
AC1L2AMM
Angeliq, Drospirenone
BRN 4765500
C035144
C24H30O3
CCRIS 6523
CHEBI:50838
 
CHEMBL1509
CID68873
D03917
DB01395
DRSP
Dehydrospirorenone
Dihydrospirorenone
Drospirenona
Drospirenona [INN-Spanish]
Drospirenona [inn-spanish]
Drospirenone
Drospirenone (JAN/USAN/INN)
Drospirenone [INN]
Drospirenonum
Drospirenonum [INN-Latin]
Drospirenonum [inn-latin]
EINECS 266-679-2
LS-146115
S1377_Selleck
SH-470
Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta
UNII-N295J34A25
ZINC03927200
ZK 30595
ZK-30595
ZK30595
12
Estradiolapproved, investigational, vet_approvedPhase 2128350-28-25757, 53477783
Synonyms:
(+)-3,17b-Estradiol
(17b)-Estra-1,3,5(10)-triene-3,17-diol
(17beta)-Estra-1,3,5(10)-triene-3,17-diol
.alpha.-Estradiol
.alpha.-Oestradiol
.beta.-Estradiol
.beta.-Oestradiol
1,3,5[10]-Estratriene-3,17beta-diol 3-sulfate
1,3,5[10]-Estratriene-3,17beta-diol 3-sulphate
13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol
17 beta-Estradiol
17-.BETA.-Estradiol
17-E
17-beta
17-beta-OH-estradiol
17-beta-estradiol
17.beta.-Estradiol
17.beta.-Oestradiol
17E
17b-Estradiol
17b-Oestradiol
17beta Oestradiol
17beta oestradiol
17beta-Estra-1,3,5(10)-triene-3,17-diol
17beta-Estradiol
17beta-Oestradiol
1jgl
1qkt
1qku
2d06
3,17-Epidihydroxyestratriene
3,17-beta-Estradiol
3,17-beta-Oestradiol
3,17.beta.-Estradiol
3,17b-Dihydroxyestra-1,3,5(10)-triene
3,17b-Estradiol
3,17beta-Estradiol
3,17beta-dihydroxy-1,3,5[10]-estratriene 3-sulfate
3,17beta-dihydroxy-1,3,5[10]-estratriene 3-sulphate
50-28-2
73459-61-7
873662-39-6
AC-10460
AC1L1L2K
Aerodiol
Agofollin
Alora
Altrad
Amnestrogen
Aquadiol
B-Estradiol
BEDOs
BIDD:ER0125
BIDD:PXR0065
BPBio1_000532
BSPBio_000482
BSPBio_001065
Bardiol
Benzhormovarine
Beta-estradiol
Bio-0812
Bio-E-Gel
Bio1_000403
Bio1_000892
Bio1_001381
Bio2_000363
Bio2_000843
C00951
C18H24O2
CCRIS 280
CHEBI:16469
CHEMBL135
CID5757
CMC_11154
CPD-352
CPD000059126
Climaderm
Climara
Climara (TN)
Climara Forte
Compudose
Compudose 200
Compudose 365
Corpagen
D-3,17beta-Estradiol
D-Estradiol
D-Oestradiol
D00105
DB00783
Dermestril
Destradiol
Dihydro-Theelin
Dihydrofollicular hormone
Dihydrofolliculin
Dihydromenformon
Dihydrotheelin
Dihydroxyesterin
Dihydroxyestrin
Dihydroxyoestrin
Dimenformon
Diogyn
Diogynets
Divigel
Divigel (TN)
E 2
E 8875
E(sub 2)
E0025
E1024_SIGMA
E1132_SIGMA
E2257_SIGMA
E2758_SIGMA
E8875_SIGMA
EINECS 200-023-8
EU-0100503
Elestrin
Encore
Epiestriol 50
Esclim
Estra-1,3,5(10)-triene-3,17b-diol
Estrace
Estrace (TN)
Estraderm
Estraderm (TN)
Estraderm MX
Estraderm TTS
Estraderm TTS 100
Estraderm TTS 50
Estradiol
Estradiol [USAN:INN]
Estradiol-17 beta
Estradiol-17-beta
Estradiol-17.beta.
Estradiol-17beta
Estradiol-3,17beta
Estradiolo
Estradiolo [DCIT]
Estradiolum
Estradiolum [INN]
Estradot
Estraldine
Estrapak 50
Estrasorb
Estrasorb (TN)
Estreva
Estrifam
Estring
Estring (TN)
Estring Vaginal Ring
Estring vaginal ring
Estroclim
Estroclim 50
Estrodiolum
Estrofem 2
Estrofem Forte
Estrogel
 
Estrogel (TN)
Estrogel HBF
Estrovite
Evamist
Evorel
Extrasorb
Femanest
Femestral
Femestrol
Femogen
Fempatch
Femtrace
Femtran
Follicyclin
Gelestra
Ginedisc
Ginosedol
GynPolar
Gynergon
Gynestrel
Gynodiol
Gynoestryl
HMS1362E07
HMS1569I04
HMS1792E07
HMS1990E07
HMS2051C17
HMS2090E18
HSDB 3589
IDI1_002118
Innofem
Innofem (TN)
KBio2_000405
KBio2_002269
KBio2_002973
KBio2_004837
KBio2_005541
KBio2_007405
KBio3_000769
KBio3_000770
KBio3_002749
KBioGR_000405
KBioGR_002269
KBioSS_000405
KBioSS_002270
LMST02010001
LS-137
Lamdiol
Lio-Oid
Lopac0_000503
MLS000069494
MLS000758312
MLS001076331
Macrodiol
Macrol
Menest
Menorest
Menostar
Microdiol
MolPort-001-794-632
NCGC00091544-00
NCGC00091544-01
NCGC00091544-02
NCGC00091544-04
NCGC00091544-05
NCGC00091544-06
NCGC00091544-07
NCGC00091544-08
NCGC00091544-09
NCGC00091544-12
NCGC00179321-01
NCGC00179321-02
NSC-9895
NSC9895
Nordicol
Oesclim
Oestergon
Oestra-1,3,5(10)-triene-3,17b-diol
Oestradiol
Oestradiol Berco
Oestradiol R
Oestradiol-17-beta
Oestradiol-17.beta.
Oestradiol-17beta
Oestradiolum
Oestrogel
Oestroglandol
Oestrogynal
Ovahormon
Ovasterol
Ovastevol
Ovociclina
Ovocyclin
Ovocycline
Ovocylin
Perlatanol
Polyestradiol
Prestwick0_000441
Prestwick1_000441
Prestwick2_000441
Prestwick3_000441
Prestwick_207
Primofol
Profoliol
Profoliol B
Progynon
Progynon DH
Progynon-DH
S-21400
S1709_Selleck
SAM001247032
SK-Estrogens
SL-1100
SMP1_000121
SMR000059126
SPBio_002421
Sandrena 1
Sandrena Gel
Sisare Gel
Spectrum5_002055
Syndiol
Systen
Tradelia
Trial SAT
Trocosone
UNII-4TI98Z838E
VIVELLE-DOT
Vagifem
Vagifem (TN)
Vivelle
Vivelle (TN)
Zerella
Zesteem
Zesteen
Zumenon
[2,4,6,7-3H]-E2
[3H]-estradiol
[3H]]estradiol
b-Estradiol
beta-Estradiol
beta-Estradiol 3-sulfate
beta-Estradiol 3-sulphate
bmse000642
cMAP_000005
cis-Estradiol
cis-Oestradiol
component of Menrium
delta-Estradiol
delta-Oestradiol
estradiol
estradiol-17beta
nchembio.168-comp3
nchembio.76-comp2
nchembio775-comp2
nchembio794-comp6
nchembio860-comp1
progynon
13Anti-Infective AgentsPhase 2, Phase 121402
14HormonesPhase 213979
15Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
16Immunosuppressive AgentsPhase 212770
17Hormone AntagonistsPhase 212778
18Dermatologic AgentsPhase 25674
19AnalgesicsPhase 211287
20Analgesics, Non-NarcoticPhase 26260
21AntibodiesPhase 2, Phase 16045
22ImmunoglobulinsPhase 2, Phase 16045
23Peripheral Nervous System AgentsPhase 222776
24Anti-Inflammatory Agents, Non-SteroidalPhase 24295
25Antibodies, MonoclonalPhase 2, Phase 13795
26Gastrointestinal AgentsPhase 28109
27Interleukin 1 Receptor Antagonist ProteinPhase 296
28Angiogenesis InhibitorsPhase 24143
29Angiogenesis Modulating AgentsPhase 24072
30Complement System ProteinsPhase 2228
31Mineralocorticoid Receptor AntagonistsPhase 2333
32Contraceptives, OralPhase 21292
33Natriuretic AgentsPhase 21645
34MineralocorticoidsPhase 2352
35Polyestradiol phosphatePhase 21283
36Contraceptive AgentsPhase 21901
37Diuretics, Potassium SparingPhase 21827
38diureticsPhase 21372
39Drospirenone and ethinyl estradiol combinationPhase 283
40Estradiol 17 beta-cypionatePhase 21283
41Estradiol valeratePhase 21283979-32-8
42Estradiol 3-benzoatePhase 21283
43EstrogensPhase 22470
44
Phenolapproved, experimentalPhase 145108-95-2996
Synonyms:
Acide carbolique
Acide phenique
Anbesol
Benzenol
Benzophenol
Campho-phenique cold sore gel
Campho-phenique gel
Campho-phenique liquid
Carbolic acid
Carbolic acid liquid
Carbolic oil
Carbolicum acidum
Carbolsaeure
Carbolsaure
Cepastat lozenges
Cuticura pain relieving ointment
Fenol
Fenolo
Fenosmolin
Fenosmoline
Hydroxy-benzene
Hydroxybenzene
IPH
IZAL
Karbolsaeure
Liquefied phenol
Liquid phenol
Liquified phenol
 
Monohydroxy benzene
Monohydroxybenzene
Monophenol
Oxybenzene
PHOH
Paoscle
Phenic
Phenic Acid
Phenic acid
Phenic alcohol
Phenol
Phenol alcohol
Phenol homopolymer
Phenol liquid
Phenol molten
Phenol polymer-bound
Phenol solution
Phenol synthetic
Phenolated water
Phenolated water for disinfection
Phenole
Phenosmolin
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic acid
Phenylic alcohol
Synthetic phenol
Tea polyphenol
45Pharmaceutical SolutionsPhase 17793
46Anti-Infective Agents, LocalPhase 11785
47DisinfectantsPhase 1547
48AnestheticsPhase 19001
49
Triamcinoloneapproved, vet_approved482124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
50
Clindamycinapproved, vet_approved16818323-44-929029
Synonyms:
13441-63-9
16669-21-9
18323-44-9
21462-39-5 (mono-hydrochloride)
24620-78-8
24696-19-3
58207-19-5
7(S)-Chloro-7-deoxylincomycin
7-CDL
7-Chloro-7-deoxylincomycin
7-Chlorolincomycin
7-Deoxy-7(S)-chlorolincomycin
AC1L1EGQ
AC1L1GLA
AC1L9JV8
AC1MHD7N
AC1MHE1M
AC1MHUOE
AC1MHX4G
AC1NWAKO
AC1O7ENS
AC1O7GED
AC1OFCIP
AC1OFCIV
AC1OFCJ1
AC1OFCJ7
AC1OIBYJ
AC1OIBYL
AC1OIBYN
AC1Q2V4O
Antirobe
BIDD:GT0418
BPBio1_000236
BRD-A23034328-003-03-4
BSPBio_000214
BSPBio_002049
C06914
C18H33ClN2O5S
CAS-21462-39-5
CHEBI:3745
CHEMBL187
CID2786
CID29029
CID3000512
CID3001928
CID3032758
CID3034218
CID446598
CID5702026
CID6602476
CID6604361
CID7048642
CID7048644
CID7048646
CID7048648
CID7276014
CID7276016
CID7276018
CID9812677
CLDM
CLINDA & IL-12
CLY
Chlolincocin
Chlorlincocin
Chlorodeoxylincomycin
Chlorolincomycin
Cleocin
Cleocin (TN)
Cleocin (tn)
Cleocin HCl
Cleocin Hcl
Cleocin Pediatric
Cleocin Phosphate
Cleocin T
Cleocin T Gel
Cleocin T Lotion
Cleocin T Topical Solution
 
Clinda-Derm
ClindaDerm
Clindagel
Clindamicina
Clindamicina [INN-Spanish]
Clindamycin
Clindamycin & Interleukin 12
Clindamycin & VRC3375
Clindamycin (USAN/INN)
Clindamycin Hcl
Clindamycin Hydrochloride
Clindamycin Phosphate
Clindamycin [USAN:BAN:INN]
Clindamycine
Clindamycine [French]
Clindamycine [INN-French]
Clindamycinum
Clindamycinum [INN-Latin]
Clindesse
Clindets
Clinimycin
D00277
DB01190
Dalacin
Dalacin C
Dalacin C Flavored Granules
Dalacin C Phosphate
Dalacin T Topical Solution
Dalacine
DivK1c_000464
EINECS 242-209-1
Evoclin
HMS2089A05
HMS2089N16
HSDB 3037
I06-0826
IDI1_000464
KBio1_000464
KBio2_000638
KBio2_003206
KBio2_005774
KBio3_001269
KBioGR_000844
KBioSS_000638
Klimicin
Klindan 300
LS-187128
LS-98131
MLS001183714
Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
MolPort-002-323-206
MolPort-002-964-479
NCGC00016752-01
NCGC00178843-01
NCGC00179636-01
NINDS_000464
Prestwick0_000137
Prestwick1_000137
Prestwick2_000137
Prestwick3_000137
ResiDerm A
SMP2_000295
SMR000677917
SPBio_000670
SPBio_002153
STK177246
STOCK1N-31150
Sobelin
Spectrum2_000885
Spectrum3_000355
Spectrum4_000292
Spectrum5_001525
Spectrum_000158
U 21251
U-21,251
U-21251
UNII-3U02EL437C
Zindaclin
clindamycin

Interventional clinical trials:

(show all 39)
idNameStatusNCT IDPhase
1Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study)RecruitingNCT02808975Phase 4
2Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis SuppurativaCompletedNCT01468207Phase 3
3Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis SuppurativaCompletedNCT01468233Phase 3
4Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis SuppurativaCompletedNCT01635764Phase 3
5Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis SuppurativaRecruitingNCT02904902Phase 3
6Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis SuppurativaNot yet recruitingNCT02805595Phase 3
7To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis SuppurativaTerminatedNCT00367328Phase 3
8To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis SuppurativaCompletedNCT00827996Phase 2
9Etanercept in Hidradenitis SuppurativaCompletedNCT00329823Phase 2
10Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa PatientsCompletedNCT02421172Phase 2
11Anakinra as a Treatment for Hydradenitis SuppurativaCompletedNCT01516749Phase 2
12Anakinra in Hidradenitis SuppurativaCompletedNCT01558375Phase 2
13A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis SuppurativaCompletedNCT01704534Phase 2
14Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis SuppurativaCompletedNCT00918255Phase 2
15Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis SuppurtativaCompletedNCT00795574Phase 2
16Etanercept for Treatment of HidradenitisCompletedNCT00107991Phase 2
17Single Center Study of Apremilast for the Treatment of Hidradenitis SuppurativaRecruitingNCT02695212Phase 2
18Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis SuppurativaRecruitingNCT03001622Phase 2
19MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMABActive, not recruitingNCT02643654Phase 2
20Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis SuppurativaTerminatedNCT01838499Phase 2
21A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HSTerminatedNCT00722800Phase 2
22Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis SuppurativaCompletedNCT00134134Phase 1
23Endoscopic Pilonidal Sinus Treatment With Additional Crystalized PhenolCompletedNCT02277340Phase 1
24An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.Unknown statusNCT01818167
25Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical DeroofingUnknown statusNCT02163746
26Trial Comparing Efficacy of Treatments for Hidradenitis SuppurativaUnknown statusNCT01063270
27Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary FistulaUnknown statusNCT01315080
28Study on the Effect of NdYag Laser for the Treatment of Hidradenitis SuppurativaCompletedNCT00494351
29A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis SuppurativaCompletedNCT00395187
30Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa PatientsCompletedNCT02833909
31Treatment of Hidradenitis Suppurativa Using EtanerceptCompletedNCT00949546
32Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life SettingRecruitingNCT02786576
33A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.RecruitingNCT02781818
34Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) PatientsRecruitingNCT02739828
35Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of IllnessRecruitingNCT02896920
36Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of LifeRecruitingNCT02904408
37Quality of Life After Wide Surgical Excision in Patients With Hidradenitis SuppurativaEnrolling by invitationNCT02593604
38Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa SubjectsNot yet recruitingNCT03001115
39Patients With Hidradenitis vs Patients With Psoriasis: Psychological ImpactNot yet recruitingNCT02999698

Search NIH Clinical Center for Acne Inversa, Familial, 1


Cochrane evidence based reviews: hidradenitis suppurativa

Genetic Tests for Acne Inversa, Familial, 1

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Genetic tests related to Acne Inversa, Familial, 1:

id Genetic test Affiliating Genes
1 Familial Acne Inversa 126
2 Hidradenitis Suppurativa, Familial26

Anatomical Context for Acne Inversa, Familial, 1

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MalaCards organs/tissues related to Acne Inversa, Familial, 1:

35
Skin, Breast

Animal Models for Acne Inversa, Familial, 1 or affiliated genes

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Publications for Acne Inversa, Familial, 1

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Variations for Acne Inversa, Familial, 1

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UniProtKB/Swiss-Prot genetic disease variations for Acne Inversa, Familial, 1:

69
id Symbol AA change Variation ID SNP ID
1NCSTNp.Pro211ArgVAR_067756

Clinvar genetic disease variations for Acne Inversa, Familial, 1:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NCSTNNCSTN, 1-BP DEL, 1752GdeletionPathogenicChr na, -1: -1
2NCSTNNCSTN, IVS13, G-A, +1SNVPathogenicChr na, -1: -1
3NCSTNNM_015331.2(NCSTN): c.349C> T (p.Arg117Ter)SNVPathogenicrs387906896GRCh37Chr 1, 160319373: 160319373

Expression for genes affiliated with Acne Inversa, Familial, 1

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Search GEO for disease gene expression data for Acne Inversa, Familial, 1.

Pathways for genes affiliated with Acne Inversa, Familial, 1

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Pathways related to Acne Inversa, Familial, 1 according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.7TNF, TNFRSF1B
2
Show member pathways
9.7TNF, TNFRSF1B
3
Show member pathways
9.7TNF, TNFRSF1B
49.7TNF, TNFRSF1B
59.3IL1RN, TNF, TNFRSF1B
6
Show member pathways
9.2APH1A, NCSTN, PSENEN
79.2APH1A, NCSTN, PSENEN
8
Show member pathways
9.2APH1A, NCSTN, PSENEN
99.2APH1A, NCSTN, PSENEN
109.2APH1A, NCSTN, PSENEN
119.2APH1A, NCSTN, PSENEN
12
Show member pathways
9.2APH1A, NCSTN, PSENEN
139.2APH1A, NCSTN, PSENEN
14
Show member pathways
8.7APH1A, NCSTN, PSENEN, TNF

GO Terms for genes affiliated with Acne Inversa, Familial, 1

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Cellular components related to Acne Inversa, Familial, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.4APH1A, NCSTN, PSENEN, TNF, TNFRSF1B
2plasma membraneGO:00058867.1APH1A, IL1RN, NCSTN, PSENEN, PSTPIP1, TNF

Biological processes related to Acne Inversa, Familial, 1 according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:005104410.3TNF, TNFRSF1B
2extrinsic apoptotic signaling pathwayGO:009719110.2TNF, TNFRSF1B
3intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.1TNF, TNFRSF1B
4membrane protein intracellular domain proteolysisGO:00312939.7APH1A, NCSTN, PSENEN
5membrane protein ectodomain proteolysisGO:00065099.5APH1A, NCSTN, PSENEN
6protein processingGO:00164859.5APH1A, NCSTN, PSENEN
7amyloid precursor protein catabolic processGO:00429879.5APH1A, NCSTN, PSENEN
8Notch receptor processingGO:00072209.2APH1A, NCSTN, PSENEN
9Notch signaling pathwayGO:00072199.2APH1A, NCSTN, PSENEN
10positive regulation of catalytic activityGO:00430859.2APH1A, NCSTN, PSENEN
11ephrin receptor signaling pathwayGO:00480139.1APH1A, NCSTN, PSENEN
12positive regulation of apoptotic processGO:00430658.4APH1A, NCSTN, PSENEN, TNF

Molecular functions related to Acne Inversa, Familial, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:00041759.5APH1A, NCSTN

Sources for Acne Inversa, Familial, 1

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet