Summaries for Acoustic Neuroma

Sources:
23MedlinePlus, 17Genetics Home Reference, 44Wikipedia, 22MalaCards
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MedlinePlus: Acoustic neuroma is a non-cancerous tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening.23

MalaCards: Acoustic Neuroma, also known as vestibular schwannoma, is related to neurofibromatosis and meningioma. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Assembly of the RAD51-ssDNA nucleoprotein complex and Dual incision reaction in GG-NER. The compounds cytosine and 2-deoxyribonolactone have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Genetics Home Reference: Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas or acoustic neuromas. These growths develop along the nerve that carries information from the inner ear to the brain (the auditory nerve). Tumors that occur on nerves in other areas of the brain or spinal cord are also commonly seen with this condition.17

Wikipedia: A vestibular schwannoma, often called an acoustic neuroma, is a benign primary intracranial tumor of the...44 more...

Aliases & Descriptions for Acoustic Neuroma

Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 23MedlinePlus, 43UMLS, 32Novoseek , 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

acoustic neuroma 6 30 8 23 43
vestibular schwannoma 6 30
neurinoma of the acoustic nerve 30
cerebellopontine angle tumor 30
acoustic neuroma (disorder) 6
vestibular neurilemmoma 6
acoustic neurilemoma 30
acoustic neurinoma 30
neuroma acoustic 32
acoustic tumor 30
neuroma 43

Related Diseases for Acoustic Neuroma

Sources:
13GeneCards, 14GeneDecks
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Diseases related to acoustic neuroma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis33.6VHL, MSH2, SST, NF2
2meningioma29.6PCNA, MKI67, PGR
3neurofibroma29.3B2M, SST, NF2, TGFB1
4retinoblastoma24.9PCNA, NBN, VHL, PARP1, MKI67, MGMT
5neuroma22.9ZNF350, PCNA, NBN, BRIP1, VHL, RAD51
6xeroderma pigmentosum, group c13.6RAD23B, XPC, ERCC5
7xeroderma pigmentosum, group f13.6ERCC4, OGG1
8dna ligase iv deficiency13.5LIG4, XRCC2, XRCC4
9growth retardation with deafness and mental retardation due to igf1 deficiency13.4NBN, LIG4, LIG1, ERCC5
10cerebrooculofacioskeletal syndrome13.4ERCC2, ERCC5
11xeroderma pigmentosum, group a13.4PCNA, XPC, ERCC4
12nijmegen breakage syndrome13.3NBN, RAD51, RAD52, LIG4, LIG1
13arachnoiditis13.3SSTR1, CRLF1, NF2, PGR
14microtia13.3XRCC1, XRCC4, ERCC2
15photosensitive trichthiodystrophy13.2BRIP1, RAD23B, XPC, ERCC2, ERCC5, ERCC4
16attenuated familial adenomatous polyposis13.2MUTYH, MSH2, APEX1, OGG1
17xeroderma pigmentosum, group d13.2XRCC1, XRCC4, XPC, ERCC2
18amyloidosis aa13.2B2M, IL6
19bloom syndrome13.2BRIP1, RAD51, RAD52, LIG1, XRCC2, ERCC2
20orofacial cleft13.2XRCC1, XRCC3, APEX1, ERCC2, OGG1
21actinic cheilitis13.1MSH2, MKI67, APEX1
22cheilitis13.1MSH2, MKI67, APEX1
23cardia cancer13.1PARP1, XRCC1, GAST
24intraepithelial neoplasm13.0PCNA, XRCC1, MKI67
25penis non-invasive verrucous carcinoma13.0MSH2, FKBP4, PGR
26microcephaly13.0NBN, LIG4, XRCC4, ERCC2, ERCC5, ERCC4
27early-onset ataxia with oculomotor apraxia and hypoalbuminemia13.0PARP1, XRCC1, XRCC4
28skin benign neoplasm13.0XPC, MSH2, MGMT, ERCC2
29basal cell carcinoma13.0XRCC1, XRCC3, MKI67, ERCC2
30papillary renal cell carcinoma13.0PCNA, VHL, MKI67, OGG1
31lynch syndrome12.9MSH2, MKI67, MGMT
32facial paralysis12.9FKBP4, NF2, TGFB1
33oculomotor apraxia12.9PARP1, XRCC1, XRCC4
34pancreatic cholera12.9SST, GAST
35apudoma12.9SST, GAST
36benign meningioma12.9PCNA, MKI67, NF2, PGR
37dna topoisomerase i12.8NBN, RAD52, PARP1, MKI67
38spina bifida12.8XRCC1, XRCC3, MGMT, APEX1, ERCC2, OGG1
39anaplastic meningioma12.8PCNA, MKI67, NF2, PGR
40pituitary carcinoma12.8PCNA, MGMT, SST
41mutagen sensitivity12.8PCNA, RAD23B, XRCC1, XRCC3, XPC, ERCC2
42glucagonoma12.8CCK, SST, GAST
43wermer syndrome12.8VHL, SST, GAST
44myoma12.8PCNA, XRCC4, ERCC2, PGR
45breast fibroadenoma12.8PCNA, MKI67, PGR
46smooth muscle tumor12.8PCNA, MKI67, APEX1, PGR
47functioning pituitary adenoma12.8PCNA, MKI67, SST, SSTR1
48benign tumors12.7PCNA, MKI67, NF2, PGR
49hereditary mucosal leukokeratosis12.7PCNA, XRCC1, MKI67, MGMT, ERCC2
50familial medullary thyroid carcinoma12.7VHL, CCK, SST, SSTR1, GAST

Graphical network of the top 20 diseases related to acoustic neuroma:



Graphical network of diseases related to acoustic neuroma

Clinical Features for Acoustic Neuroma

Drugs & Therapeutics for Acoustic Neuroma

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for acoustic neuroma

Search CenterWatch for acoustic neuroma

Genetic Tests for Acoustic Neuroma

Anatomical Context for Acoustic Neuroma

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22MalaCards
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MalaCards organs/tissues related to acoustic neuroma:

22
Brain, Spinal cord

Phenotypes for genes affiliated with Acoustic Neuroma

Sources:
25MGI
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Publications for genes affiliated with Acoustic Neuroma

Sources:
35PubMed
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Articles related to acoustic neuroma:

(show all 11)
idTitleAuthorsYearAffiliating Genes
1DNA repair gene polymorphisms and risk of adult menin gioma, glioma, and acoustic neuroma. (20150366)Rajaraman P.... Inskip P.D.2010LIG1, RAD51, PARP1
2Relevance between clinical behavior and bionomical f indings of acoustic neuromas]. (18510217)Yang S.M.... Yang W.Y.2008TGFB1, PCNA, MKI67
3The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas. (14747443)Stafford N.D.... Atkin S.L.2004SSTR1
4Association of proliferative activity and size in acoustic neuroma: implications for timing of surgery. (12691406)Bedavanija A.... Mann W.J.2003PCNA
5Transforming growth factor-beta1 expression in human acoustic neuroma. (9918175)Cardillo M.R.... Barbara M.1999TGFB1, NRG1
6Clinicopathologic growth factors of acoustic neuromas. (7482232)Kawamoto Y.... Sugiyama K.1995PCNA
7Human acoustic neuromas secrete interleukin-6 in cell culture: possible autocrine regulation of cell proliferation. (7800135)Adams E.F.... Fahlbusch R.1994IL6
8Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. (8217082)Irving R.M.... Maher E.R.1993VHL
9Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. (1432035)Lee J.K.... Martuza R.L.1992B2M
10Gastrin, cholecystokinin and their precursors in acoustic neuromas. (1702342)Rehfeld J.F.... Thomsen J.1990SST, CCK, GAST
11Estrogen and progesterone receptors in acoustic neuromas. (2297415)Klinken L.... Tos M.1990PGR

Expression for genes affiliated with Acoustic Neuroma

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Acoustic Neuroma

Pathways for genes affiliated with Acoustic Neuroma

Sources:
38Reactome, 41Thomson Reuters, 20KEGG, 36QIAGEN, 10EMD Millipore, 3Cell Signaling Technology
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Compounds for genes affiliated with Acoustic Neuroma

Sources:
32Novoseek , 18HMDB, 9DrugBank, 34PharmGKB, 42Tocris Bioscience
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Compounds related to acoustic neuroma according to GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cytosine32 18 11.5RAD51, POLB
22-deoxyribonolactone32 10.3APEX1, POLB, OGG1
38-oxo-dgtp32 18 11.3POLB, OGG1, MUTYH
4thymine glycol32 10.2APEX1, ERCC5, OGG1, POLB
5sugar phosphate32 10.1RAD51, APEX1, POLB
6phosphodiester32 10.1POLB, ERCC5, OGG1, APEX1, LIG1
7benzene32 10.0XRCC1, APEX1, OGG1, XRCC3
88-oxo-dg32 9.8LIG1, PCNA, APEX1, MUTYH, POLB, OGG1
9polynucleotide32 9.7RAD51, POLB, APEX1, XRCC4, XRCC1, LIG4
10thymine32 18 10.7POLB, APEX1, OGG1, RAD51, XPC, MGMT
11pancreozymin32 9.7CCK, PGR, GAST
12minigastrin32 9.7GAST, CCK, SST
13adpribose32 9.6PCNA, PARP1, APEX1, XRCC1, POLB, LIG1
14adenine32 9 18 9 12.5POLB, RAD51, MUTYH, OGG1, MSH2, APEX1
158-oxoguanine32 9.4MGMT, OGG1, APEX1, MUTYH, POLB, XRCC1
16aphidicolin32 9.4PCNA, POLB, LIG1, RAD51
17o6-methylguanine32 9.4MSH2, RAD51, PCNA, MGMT, APEX1, POLB
18loxiglumide32 9.3GAST, CCK, SST
19temozolomide32 9 9 11.3MSH2, PCNA, PARP1, MGMT, XRCC1
20irinotecan32 34 9 9 12.2PARP1, MKI67, XRCC1, ERCC2, MGMT
21mnng32 9.2XRCC1, PCNA, PARP1, MSH2, POLB, MGMT
22octreotide32 42 9 9 12.2CCK, GAST, SSTR1, SST, MKI67
23caffeine32 34 9 18 9 13.2SST, PCNA, RAD51, LIG1, XRCC2, XRCC3
24ascorbic acid32 18 10.2GAST, APEX1, POLB, OGG1, XRCC1, PCNA
25acetaminophen32 34 9 18 9 13.0PCNA, CCK, GAST, PGR, B2M
26mitomycin c32 9.0NBN, POLB, ERCC4, PCNA, MGMT, RAD51
27etoposide32 42 9 9 11.9TGFB1, XRCC1, PARP1, LIG1, PCNA, MGMT
28melphalan32 9 9 10.9ERCC2, POLB, ERCC4, IL6, MGMT, XRCC3
29camptothecin32 42 9 9 11.9NBN, PCNA, RAD51, RAD52, XRCC1, PARP1
30methylmethanesulfonate32 8.8OGG1, APEX1, MGMT, XRCC1, RAD52, RAD51
31formaldehyde32 18 9.5PCNA, B2M, MKI67, MGMT, APEX1, TGFB1
32thymidylate32 8.3MSH2, B2M, PCNA, RAD51, XRCC1, MGMT
33thyroxine32 18 9.2B2M, SST, TGFB1, PGR, GAST, PCNA
34bromodeoxyuridine32 8.1MKI67, GAST, TGFB1, NRG1, PCNA, APEX1
35glutamine32 8.0PGR, OGG1, TGFB1, CCK, B2M, XRCC1
36folate32 7.9CCK, VHL, XRCC1, XRCC3, B2M, MKI67
37methotrexate32 34 42 9 9 11.9MKI67, MGMT, IL6, PGR, PCNA, POLB
385fluorouracil32 7.7ERCC4, ERCC2, CCK, MGMT, MSH2, PCNA
39oligonucleotide32 7.3LIG1, VHL, PCNA, ERCC5, RAD51, XRCC1
40paclitaxel32 34 9 9 10.2PGR, TGFB1, PCNA, RAD51, PARP1, MKI67
41paraffin32 6.9MGMT, PCNA, SSTR1, TGFB1, NF2, NRG1
42testosterone32 9 18 9 9.8NRG1, B2M, GAST, PGR, SST, CCK
43thymidine32 18 7.6GAST, POLB, NRG1, ERCC4, PCNA, RAD51
44cycloheximide32 6.6IL6, FKBP4, RAD51, MKI67, B2M, PARP1
45doxorubicin32 34 9 9 9.6MSH2, MKI67, TGFB1, MGMT, SST, NBN
46estrogen32 6.3MGMT, PCNA, VHL, GAST, PGR, NRG1
47alanine32 6.2APEX1, MSH2, LIG4, RAD51, NRG1, XRCC4
48retinoic acid32 42 18 7.6PARP1, TGFB1, NRG1, SST, IL6, MGMT
49vegf32 5.4IL6, MKI67, B2M, GAST, ERCC2, PARP1
50cisplatin32 34 9 9 8.4PCNA, POLB, TGFB1, NRG1, ERCC4, RAD51

GO Terms for genes affiliated with Acoustic Neuroma

Sources:
12Gene Ontology
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Cellular components related to acoustic neuroma according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA ligase IV complexGO:03280710.0LIG4, XRCC4
2XPC complexGO:0719429.9XPC, RAD23B
3condensed chromosomeGO:0007939.6MKI67, XRCC4, LIG4, RAD51
4nucleolusGO:0057307.9PGR, OGG1, NF2, APEX1, FKBP4, MKI67
5nucleoplasmGO:0056546.5PCNA, XPC, MGMT, APEX1, ERCC2, ERCC5
6cytoplasmGO:0057376.0POLB, OGG1, TGFB1, NF2, CRLF1, NRG1
7nucleusGO:0056343.9ERCC5, ERCC2, APEX1, MGMT, FKBP4, MKI67

Biological processes related to acoustic neuroma according to GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.4RAD23B, XPC
2nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.4ERCC5, ERCC4
3UV protectionGO:00965010.3ERCC4, ERCC5, ERCC2
4DNA ligation involved in DNA repairGO:05110310.3LIG4, LIG1, XRCC4
5positive regulation of neurogenesisGO:05076910.3XRCC4, XRCC2, LIG4
6depurinationGO:04500710.3MUTYH, OGG1
7nucleotide-excision repair, DNA incisionGO:03368310.1ERCC4, ERCC2
8response to gamma radiationGO:01033210.1XRCC4, XRCC2, LIG4
9nucleotide-excision repair, DNA damage removalGO:00071810.1ERCC4, ERCC5, ERCC2, XPC, RAD23B
10nucleotide-excision repair, DNA gap fillingGO:00629710.1POLB, LIG1, LIG4, PCNA
11T cell differentiation in thymusGO:03307710.1B2M, XRCC4, LIG4
12immunoglobulin V(D)J recombinationGO:03315210.0XRCC4, LIG4
13response to X-rayGO:01016510.0LIG4, XRCC2, XRCC4, MSH2
14double-strand break repair via homologous recombinationGO:00072410.0ERCC4, XRCC2, LIG1, RAD52, RAD51, NBN
15mismatch repairGO:0062989.9MSH2, MUTYH, PCNA
16isotype switchingGO:0451909.9NBN, LIG4, XRCC4, MSH2
17transcription-coupled nucleotide-excision repairGO:0062839.9ERCC4, ERCC5, ERCC2, LIG1, PCNA
18mitotic recombinationGO:0063129.9RAD52, RAD51
19meiosisGO:0071269.9NBN, RAD51, XRCC2, MKI67
20negative regulation of neuron apoptotic processGO:0435249.9CRLF1, MSH2, XRCC4, XRCC2, LIG4
21double-strand break repairGO:0063029.7XRCC4, LIG1, LIG4, RAD52, RAD51, BRIP1
22telomere maintenanceGO:0007239.7RTEL1, ERCC4, PARP1, LIG1, NBN, PCNA
23in utero embryonic developmentGO:0017019.7ERCC2, MSH2, XRCC4, XRCC2, LIG4
24nucleotide-excision repairGO:0062899.5OGG1, ERCC4, ERCC5, ERCC2, XPC, LIG1
25base-excision repairGO:0062849.2POLB, OGG1, APEX1, XRCC1, MUTYH, PARP1
26cell proliferationGO:0082838.5NRG1, ERCC2, MKI67, LIG4, NBN, PCNA
27negative regulation of cell proliferationGO:0082858.4VHL, IL6, SST, SSTR1, NF2, TGFB1
28response to drugGO:0424938.3TGFB1, SST, MGMT, MSH2, B2M, XRCC1
29DNA repairGO:0062816.6PCNA, XPC, MSH2, MGMT, APEX1, ERCC2

Molecular functions related to acoustic neuroma according to GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1endodeoxyribonuclease activityGO:00452010.2ERCC4, ERCC5, APEX1
2DNA ligase activityGO:00390910.1LIG1, LIG4
3ATP-dependent DNA helicase activityGO:00400310.1RTEL1, ERCC2, BRIP1, NBN
44 iron, 4 sulfur cluster bindingGO:05153910.0RTEL1, ERCC2, MUTYH, BRIP1
5endonuclease activityGO:00451910.0MUTYH, APEX1, ERCC5, OGG1
6MutLalpha complex bindingGO:0324059.9PCNA, MUTYH, MSH2
7dinucleotide insertion or deletion bindingGO:0321399.8MSH2, PCNA
8DNA-dependent ATPase activityGO:0080949.7ERCC2, XRCC3, XRCC2
9single-stranded DNA bindingGO:0036979.7ERCC4, ERCC5, MSH2, XPC, RAD23B, RAD51
10damaged DNA bindingGO:0036849.3NBN, POLB, OGG1, ERCC4, APEX1, XPC
11protein N-terminus bindingGO:0474859.2TGFB1, ERCC4, ERCC5, ERCC2, PARP1, NBN
12metal ion bindingGO:0468729.1RTEL1, POLB, PDE8A, ERCC5, ERCC2, APEX1
13protein C-terminus bindingGO:0080229.1ERCC4, ERCC2, MKI67, MSH2, XRCC4, LIG4
14ATP bindingGO:0055248.4ERCC2, FKBP4, MKI67, MSH2, XRCC3, XRCC2
15DNA bindingGO:0036777.7MSH2, MGMT, APEX1, ERCC2, RTEL1, PGR
16protein bindingGO:0055153.8ERCC5, ERCC2, GLTSCR1, APEX1, FKBP4, MKI67

Sources for Acoustic Neuroma

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS