MCID: ACS001
MIFTS: 43

Acoustic Neuroma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Acoustic Neuroma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 32MedlinePlus, 60UMLS, 43Novoseek, 55SNOMED-CT, 33MeSH, 38NCIt, 61UMLS via Orphanet
See all sources

Acoustic Neuroma, Aliases & Descriptions:

Name: Acoustic Neuroma 9 41 11 47 32 60
Vestibular Schwannoma 9 41 47
Cerebellopontine Angle Tumor 41 60
Acoustic Neurilemoma 41 47
Acoustic Neurinoma 41 47
 
Neurinoma of the Acoustic Nerve 41
Vestibular Neurilemmoma 9
Neuroma Acoustic 43
Acoustic Tumor 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
acoustic neuroma:
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000


External Ids:

Disease Ontology9 DOID:12689
MeSH33 D009464
NCIt38 C3276
Orphanet47 252175
UMLS via Orphanet61 C0027859

Summaries for Acoustic Neuroma

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MedlinePlus:32 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute on deafness and communication disorders

MalaCards based summary: Acoustic Neuroma, also known as vestibular schwannoma, is related to neuroma and cerebrospinal fluid leak. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Homologous Recombination Repair and Homologous recombination. The compounds camptothecin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are growth/size/body and tumorigenesis.

Related Diseases for Acoustic Neuroma

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Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to acoustic neuroma

Symptoms for Acoustic Neuroma

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Drugs & Therapeutics for Acoustic Neuroma

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Drug clinical trials:

Search ClinicalTrials for Acoustic Neuroma

Search NIH Clinical Center for Acoustic Neuroma

Genetic Tests for Acoustic Neuroma

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Anatomical Context for Acoustic Neuroma

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MalaCards organs/tissues related to Acoustic Neuroma:

31
Brain, Testes, Bone, Eye, Lung, B cells, Temporal lobe, Pituitary

Animal Models for Acoustic Neuroma or affiliated genes

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MGI Mouse Phenotypes related to Acoustic Neuroma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0NF2, RAD52, XRCC2, LIG4, AQP4
2MP:00020067.8NF2, RAD52, XRCC2, LIG4, MUTYH
3MP:00036317.4AQP4, MUTYH, LIG4, XRCC2, NF2
4MP:00053767.2AQP4, MUTYH, LIG4, XRCC2, RAD52, NF2
5MP:00107687.1AQP4, MUTYH, LIG4, XRCC2, RAD52, NF2

Publications for Acoustic Neuroma

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Articles related to Acoustic Neuroma:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Acoustic neuroma manifesting as toothache and numbness. (25625716)
2015
2
Radiosurgery, a treatment for acoustic neuroma. Ten years' experience. (24846561)
2014
3
Retrosigmoid craniotomy for resection of acoustic neuroma with hearing preservation: a video publication. (24380523)
2014
4
Validation of self-reported start year of mobile phone use in a Swedish case-control study on radiofrequency fields and acoustic neuroma risk. (25352163)
2014
5
The case of acoustic neuroma: Comment on: Mobile phone use and risk of brain neoplasms and other cancers. (24078153)
2013
6
A case of gastric cancer manifesting as a solitary brain metastasis in the cerebellopontine angle that mimicked acoustic neuroma. (24400217)
2013
7
Recurrent nasopharyngeal carcinoma masquerading as acoustic neuroma. (22434308)
2012
8
Acoustic neuroma neurophysiologic correlates: vestibular-preoperative, intraoperative, and postoperative. (22483818)
2012
9
Acoustic neuroma surgery for preservation of hearing: technique and experience in the Chinese PLA General Hospital. (20406132)
2010
10
Acoustic neuroma identified after electroconvulsive therapy in a patient with recurrent major depression and undifferentiated somatoform disorder. (20357670)
2010
11
Re: Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma. (20447172)
2010
12
Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. (19289391)
2009
13
Future perspectives in acoustic neuroma management. (18810226)
2008
14
Management of unilateral vestibular schwannoma/acoustic neuroma. (18264185)
2007
15
Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. (17414174)
2007
16
Acoustic neuroma in a private neurotology practice: trends in demographics and practice patterns. (17828042)
2007
17
Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. (17019705)
2007
18
Conservative management of acoustic neuroma. (17077873)
2006
19
Counseling patients on surgical options for treating acoustic neuroma. (16005723)
2005
20
Stress hormones in MAcniA"re's disease and acoustic neuroma. (15925138)
2005
21
The prevalence of "incidental" acoustic neuroma. (15781765)
2005
22
Cerebrospinal fluid leak after acoustic neuroma surgery: a comparison of the translabyrinthine, middle fossa, and retrosigmoid approaches. (12544038)
2003
23
Management of unilateral acoustic neuroma in a 72-year-old patient with contralateral congenital deafness. (12447251)
2002
24
Acoustic neuroma surgery and tinnitus. (12115076)
2002
25
Factors affecting recovery after acoustic neuroma resection. (12542203)
2002
26
Symptomatic subdural hygroma and temporal lobe edema after translabyrinthine removal of acoustic neuroma. (17167613)
2001
27
Acoustic neuroma: predominance of Antoni type B cells in tumors of patients with vestibular paresis. (11300272)
2001
28
Cerebrospinal fluid leak after acoustic neuroma surgery: influence of tumor size and surgical approach on incidence and response to treatment. (11213957)
2001
29
Nuances in acoustic neuroma surgery. (11504109)
2001
30
Vasoactive treatment for hearing preservation in acoustic neuroma surgery. (11702866)
2001
31
Consensus meeting on systems for reporting results in acoustic neuroma. November 7-9, 2001. Tokyo, Japan. Abstracts. (11758537)
2001
32
Results of acoustic neuroma radiosurgery: an analysis of 5 years' experience using current methods. (11147876)
2001
33
Impact of facial paralysis on patients with acoustic neuroma. (10983957)
2000
34
Evaluation of three intraoperative auditory monitoring techniques in acoustic neuroma surgery. (10733192)
2000
35
Acoustic neuroma: outcome of surgical resection and study on the anatomy of facial and cochlear nerves. (10575527)
1999
36
Management of acoustic neuroma. (10206835)
1999
37
Stereocilia-like structures in the endolymphatic sac in MAcniA"re's disease and acoustic neuroma. (9892873)
1999
38
Suboccipital resection of a medial acoustic neuroma with hearing preservation. (10321887)
1999
39
General anesthesia with remifentanil for Cesarean section in a parturient with an acoustic neuroma. (10391607)
1999
40
Endoscopy of the posterior fossa and endoscopic dissection of acoustic neuroma. (16681355)
1999
41
Disability from vestibular symptoms after acoustic neuroma resection. (9455958)
1998
42
Acoustic neuroma presenting as orofacial anethesia. (11507494)
1998
43
Intra-operative monitoring in acoustic neuroma surgery. (9785586)
1998
44
Pneumocephalus after acoustic neuroma surgery. (9831162)
1998
45
Stereotactic radiosurgery for acoustic neuroma: a Canadian perspective. (9827233)
1998
46
Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention. (9202266)
1997
47
Individualizing hearing preservation in acoustic neuroma surgery. (9261005)
1997
48
Sensorineural hearing loss and cerebellopontine angle lesions. Not always an acoustic neuroma--a pictorial essay. (9156313)
1997
49
Surgical treatment of acoustic neuroma (vestibular schwannoma) in the United States: report from the Acoustic Neuroma Registry. (8544629)
1996
50
Ramsay Hunt syndrome mimicking acoustic neuroma on MRI. (7499937)
1995

Variations for Acoustic Neuroma

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Expression for genes affiliated with Acoustic Neuroma

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Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for genes affiliated with Acoustic Neuroma

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Compounds for genes affiliated with Acoustic Neuroma

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Compounds related to Acoustic Neuroma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1camptothecin43 59 1211.1RAD52, XRCC2
2cyclophosphamide43 49 1211.1RAD52, MUTYH
3cisplatin43 49 59 1211.5RAD52, XRCC2, MUTYH

GO Terms for genes affiliated with Acoustic Neuroma

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Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:00101659.6XRCC2, LIG4
2positive regulation of neurogenesisGO:00507699.6XRCC2, LIG4
3response to gamma radiationGO:00103329.5LIG4, XRCC2
4negative regulation of neuron apoptotic processGO:00435249.5XRCC2, LIG4
5double-strand break repair via homologous recombinationGO:00007249.3RAD52, XRCC2
6double-strand break repairGO:00063029.2RAD52, LIG4
7DNA repairGO:00062818.3RAD52, XRCC2, LIG4, MUTYH

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.4NF2, RAD52, ZNF350, XRCC2, LIG4, MUTYH

Products for genes affiliated with Acoustic Neuroma

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Sources for Acoustic Neuroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet