MCID: ACS001
MIFTS: 60

Acoustic Neuroma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 72 49 55 40 14 69
Vestibular Schwannoma 12 49 55 28
Cerebellopontine Angle Tumor 49 69
Acoustic Neurilemoma 49 55
Acoustic Neurinoma 49 55
Neurinoma of the Acoustic Nerve 49
Vestibular Neurilemmoma 12
Neuroma, Acoustic 41
Neuroma Acoustic 51
Acoustic Tumor 49

Characteristics:

Orphanet epidemiological data:

55
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 41 D009464
NCIt 46 C3276
Orphanet 55 ORPHA252175
UMLS via Orphanet 70 C0027859
ICD10 via Orphanet 33 D33.3

Summaries for Acoustic Neuroma

MedlinePlus : 40 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neuroma and facial paralysis, and has symptoms including sleeplessness, equilibration disorder and vertigo/dizziness. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Schwannoma.

Wikipedia : 72 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 neuroma 32.1 BICRA NF2 TGFB1
2 facial paralysis 30.8 NF2 TGFB1
3 communicating hydrocephalus 29.9 OGG1 TGFB1
4 cerebellopontine angle tumor 12.4
5 neurofibromatosis, type iv, of riccardi 12.1
6 neurofibromatosis, type ii 11.3
7 neurofibromatosis, type i 11.3
8 schwannomatosis 1 11.0
9 benign meningioma 10.3 NF2 PCNA
10 malignant ependymoma 10.3 ERCC5 NF2
11 cerebrospinal fluid leak 10.3
12 headache 10.3
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
14 cockayne syndrome a 10.3 ERCC4 ERCC5
15 fibrillary astrocytoma 10.3 MGMT PCNA
16 meningioma, familial 10.3
17 cerebro-oculo-facio-skeletal syndrome 10.2 ERCC4 ERCC5
18 spinal cord ependymoma 10.2 AQP1 NF2
19 intracranial hypertension, idiopathic 10.2 AQP1 OGG1
20 xeroderma pigmentosum, complementation group g 10.2 ERCC4 ERCC5
21 branchiootic syndrome 1 10.2
22 meningitis 10.2
23 glioma 10.2
24 xeroderma pigmentosum, complementation group f 10.1 ERCC4 ERCC5
25 hydrocephalus 10.1
26 salivary gland adenoid cystic carcinoma 10.1 AQP1 PCNA
27 myoclonus and ataxia 10.0
28 hydrops, lactic acidosis, and sideroblastic anemia 10.0
29 sensorineural hearing loss 10.0
30 glioblastoma 10.0
31 aneurysm 10.0
32 attenuated familial adenomatous polyposis 10.0 MSH2 OGG1
33 glioma susceptibility 1 10.0
34 anxiety 10.0
35 episodic pain syndrome, familial, 1 10.0
36 mastoiditis 10.0
37 arachnoiditis 10.0
38 central nervous system origin vertigo 10.0
39 glioblastoma multiforme 10.0
40 cerebritis 10.0
41 herpes simplex 10.0
42 xeroderma pigmentosum, variant type 9.9 ERCC4 ERCC5 OGG1
43 ependymoma 9.9 MGMT NF2
44 otitis media 9.8
45 trigeminal neuralgia 9.8
46 lung cancer 9.8
47 costello syndrome 9.8
48 aging 9.8
49 nasopharyngeal carcinoma 9.8
50 gastric cancer 9.8

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


sleeplessness, equilibration disorder, vertigo/dizziness, sore throat, chronic pain, tremor, tinnitus, syncope, snoring, seizures, sciatica, pain, headache, coughing, back pain

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.7 BRIP1 ERCC4 LIG1 MGMT MSH2 OGG1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 LIG1 PCNA TGFB1 AQP1 ERCC4
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 LIG1 PCNA TGFB1 AQP1 ERCC4 BRIP1
4 Synthetic lethal with cisplatin GR00101-A-1 8.96 BRIP1 NF2

MGI Mouse Phenotypes related to Acoustic Neuroma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ABCA2 AQP1 BRIP1 ERCC5 LIG1 MGMT
2 endocrine/exocrine gland MP:0005379 9.87 TGFB1 AQP1 BRIP1 LIG1 MGMT NF2
3 liver/biliary system MP:0005370 9.7 BRIP1 ERCC4 ERCC5 LIG1 NF2 OGG1
4 mortality/aging MP:0010768 9.7 MGMT MSH2 NF2 OGG1 PCNA TGFB1
5 neoplasm MP:0002006 9.17 BRIP1 LIG1 MGMT MSH2 NF2 OGG1

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Early Phase 1
2 Anti-Infective Agents Phase 4,Phase 2,Early Phase 1
3 Gentamicins Phase 4
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6 Antiemetics Phase 3
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Antineoplastic Agents, Hormonal Phase 3
9 Autonomic Agents Phase 3
10 Gastrointestinal Agents Phase 3
11 glucocorticoids Phase 3
12 Hormone Antagonists Phase 3
13 Hormones Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Methylprednisolone acetate Phase 3
16 Methylprednisolone Hemisuccinate Phase 3
17 Neuroprotective Agents Phase 3
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Prednisolone acetate Phase 3
20 Prednisolone hemisuccinate Phase 3
21 Prednisolone phosphate Phase 3
22 Protective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 6436030 5284616
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
30 Protein Kinase Inhibitors Phase 2,Early Phase 1
31 Angiogenesis Inhibitors Phase 2,Phase 1
32 Angiogenesis Modulating Agents Phase 2,Phase 1
33 Antibodies Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunoglobulins Phase 2
36 Antibiotics, Antitubercular Phase 2,Early Phase 1
37 Antifungal Agents Phase 2,Early Phase 1
38 Immunosuppressive Agents Phase 2,Early Phase 1
39 Endostatins Phase 2 71581480
40 Analgesics Phase 2
41 Analgesics, Non-Narcotic Phase 2
42 Anti-Inflammatory Agents, Non-Steroidal Phase 2
43 Antipyretics Phase 2
44 Antirheumatic Agents Phase 2
45 Cyclooxygenase Inhibitors Phase 2
46 Fibrinolytic Agents Phase 2
47 Platelet Aggregation Inhibitors Phase 2
48
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
49
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
50 Alkylating Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 51)

# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
6 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
12 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
13 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
14 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2 Axitinib
15 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
16 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2 Icotinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 Study of Aspirin in Patients With Vestibular Schwannoma Not yet recruiting NCT03079999 Phase 2 Aspirin;Placebo
22 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
25 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
26 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1 lapatinib
27 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231
28 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
29 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 gentamicin
30 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099
31 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
32 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
33 A Family Study of Adults With Glioma Completed NCT00339352
34 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
35 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
36 Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study Recruiting NCT01938677
37 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325
38 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
39 Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy Recruiting NCT01129687
40 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1 AR-42
41 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
42 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Recruiting NCT02811718
43 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Active, not recruiting NCT01880749 Early Phase 1 RAD001
44 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
45 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678
46 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Not yet recruiting NCT02948790
47 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Not yet recruiting NCT03097822
48 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Not yet recruiting NCT03210285
49 Endoscopic-assisted Microsurgical Removal of Cerebellopontine Angle Lesions Not yet recruiting NCT03228511
50 Hearing Handicap in Patients With Single Sided Deafness Withdrawn NCT02525640

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Genetic tests related to Acoustic Neuroma:

# Genetic test Affiliating Genes
1 Vestibular Schwannoma 28

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

38
Brain, Testes, Bone, Temporal Lobe, Pituitary, Lung, Eye

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 595)
# Title Authors Year
1
Increased sensibility to acute acoustic and blast trauma among patients with acoustic neuroma. ( 29184217 )
2018
2
Transcanal Transpromontorial Acoustic Neuroma Surgery: Results and Facial Nerve Outcomes. ( 29227438 )
2018
3
The impact of acoustic neuroma on long-term quality-of-life outcomes in the United Kingdom. ( 29330600 )
2018
4
Ophthalmic Complications Following Acoustic Neuroma Resection. ( 29253289 )
2018
5
Patient Decision Making in Vestibular Schwannoma: A Survey of the Acoustic Neuroma Association. ( 29436268 )
2018
6
Conservative treatment of vestibular schwannoma: growth and Penn Acoustic Neuroma Quality of Life scale in French language. ( 28872162 )
2017
7
Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: AA Preliminary Report. ( 28258282 )
2017
8
Impact of insurance status and race on receipt of treatment for acoustic neuroma: A national cancer database analysis. ( 28343920 )
2017
9
Peripheral nerve function estimation by linear model of multi-CMAP responses for surgical intervention in acoustic neuroma surgery. ( 29192065 )
2017
10
The Top 50 Most-Cited Articles on Acoustic Neuroma. ( 29288105 )
2017
11
A systematic review about the position-related complications of acoustic neuroma surgery via suboccipital retrosigmoid approach: Sitting versus lateral. ( 28761510 )
2017
12
Complications of the Middle Cranial Fossa Approach for Acoustic Neuroma Removal. ( 28816690 )
2017
13
Influencing Factors Analysis of Facial Nerve Function after the Microsurgical Resection of Acoustic Neuroma. ( 28264236 )
2017
14
Probabilistic Multiple-Bias Modeling Applied to the Canadian Data From the Interphone Study of Mobile Phone Use and Risk of Glioma, Meningioma, Acoustic Neuroma, and Parotid Gland Tumors. ( 28535174 )
2017
15
Operative Mortality Rates of Acoustic Neuroma Surgery: A National Cancer Database Analysis. ( 28187056 )
2017
16
Validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) for Spanish-Speaking Patients. ( 28116984 )
2017
17
Validation of the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale. ( 28391530 )
2017
18
Signs and Symptoms of Acoustic Neuroma at Initial Presentation: An Exploratory Analysis. ( 29348989 )
2017
19
Acoustic Neuroma (Vestibular Schwannoma) ( 29262098 )
2017
20
Postoperative Headache after Undergoing Acoustic Neuroma Surgery via the Retrosigmoid Approach. ( 29021412 )
2017
21
Multistep translation and cultural adaptation of the Penn acoustic neuroma quality-of-life scale for German-speaking patients. ( 28861705 )
2017
22
Resection planning for robotic acoustic neuroma surgery. ( 28612038 )
2017
23
The Persistence of Tinnitus after Acoustic Neuroma Surgery. ( 27095048 )
2016
24
Multifactor Influences of Shared Decision-Making in Acoustic Neuroma Treatment. ( 27930442 )
2016
25
Dorsal displacement of the facial nerve in acoustic neuroma surgery: clinical features and surgical outcomes of 21 consecutive dorsal pattern cases. ( 26621676 )
2016
26
Acoustic Neuroma Mimicking Orofacial Pain: A Unique Case Report. ( 28053796 )
2016
27
Hearing preservation in acoustic neuroma resection: Analysis of petrous bone measurement and intraoperative application. ( 28144470 )
2016
28
Change in tinnitus after acoustic neuroma removal using a translabyrinthine approach. A Prospective study. ( 27067182 )
2016
29
Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis. ( 26996581 )
2016
30
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016
31
Summary and consensus in 7th International Conference on acoustic neuroma: An update for the management of sporadic acoustic neuromas. ( 29204572 )
2016
32
SU-F-T-612: Investigation of Acoustic Neuroma Planning for Stereotactic Radiosurgery Utilizing Linac-Based Cone Collimators. ( 28046447 )
2016
33
Suspected Acoustic Neuroma Demyelinating Lesions. ( 27579562 )
2016
34
Suspected Acoustic Neuroma Demyelinating Lesions. ( 28005807 )
2016
35
SU-F-T-611: Critical Analysis and Efficacy of Linac Based (Beam Modulator) and Cyberknife Treatment Plans for Acoustic Neuroma/schwannoma. ( 28047111 )
2016
36
The Fully Endoscopic Acoustic Neuroma Surgery. ( 27565388 )
2016
37
Acoustic neuroma as first sign of inner ear functional disorders. ( 27935543 )
2016
38
Surgical treatment of acoustic neuroma: Outcomes and indications. ( 27330426 )
2016
39
In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging-based fiber tracking. ( 26722859 )
2016
40
Tinnitus following treatment for sporadic Acoustic neuroma. ( 26403598 )
2015
41
Facial reanimation after acoustic neuroma resection: options and timing of intervention. ( 25958894 )
2015
42
Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma. ( 25813527 )
2015
43
Abducens nerve schwannoma in cerebellopontine angle mimicking acoustic neuroma. ( 25759926 )
2015
44
Electroacupuncture therapy for abducent palsy after acoustic neuroma surgery. ( 25739636 )
2015
45
When is an acoustic neuroma not an acoustic neuroma? Pitfalls for radiosurgeons. ( 26041515 )
2015
46
Self-reported symptoms and patient experience: A British Acoustic Neuroma Association survey. ( 26523744 )
2015
47
Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study. ( 26645964 )
2015
48
Chronic balance disorders after acoustic neuroma surgery: assessment of gravitational vertical perception. ( 25748558 )
2015
49
Retrosigmoid Versus Translabyrinthine Approach for Acoustic Neuroma Resection: An Assessment of Complications and Payments in a Longitudinal Administrative Database. ( 26623224 )
2015
50
Impact of Elevation of Temporal Lobe During Middle Fossa Acoustic Neuroma Surgery on Contralateral Speech Discrimination. ( 26536414 )
2015

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 BRIP1 ERCC4 ERCC5 LIG1 MGMT MSH2
2
Show member pathways
12.51 ERCC4 ERCC5 LIG1 PCNA
3 12.02 BRIP1 ERCC4 MGMT MSH2 PCNA
4
Show member pathways
11.93 BRIP1 ERCC4 PCNA
5
Show member pathways
11.77 ERCC4 ERCC5 LIG1 MGMT MSH2 OGG1
6 11.74 ERCC5 MGMT MSH2 PCNA
7
Show member pathways
11.62 ERCC4 ERCC5 LIG1 PCNA
8
Show member pathways
11.54 LIG1 MSH2 PCNA
9
Show member pathways
10.92 ERCC4 MGMT
10 10.87 ERCC4 MSH2

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.76 BRIP1 ERCC4 ERCC5 LIG1 MGMT MSH2
2 nucleus GO:0005634 9.36 AQP1 BRIP1 ERCC4 ERCC5 LIG1 MGMT
3 nuclear chromosome, telomeric region GO:0000784 9.13 ERCC4 MSH2 PCNA

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 AQP1 ERCC5 MGMT OGG1
2 DNA replication GO:0006260 9.79 BRIP1 LIG1 PCNA
3 response to drug GO:0042493 9.77 ABCA2 AQP1 MGMT OGG1 TGFB1
4 response to estradiol GO:0032355 9.71 OGG1 PCNA TGFB1
5 telomere maintenance GO:0000723 9.65 ERCC4 PCNA
6 response to radiation GO:0009314 9.65 OGG1 TGFB1
7 cellular response to UV GO:0034644 9.65 AQP1 ERCC4 PCNA
8 base-excision repair GO:0006284 9.64 LIG1 OGG1
9 liver regeneration GO:0097421 9.64 PCNA TGFB1
10 cellular response to ionizing radiation GO:0071479 9.63 MGMT TGFB1
11 nucleotide-excision repair GO:0006289 9.63 ERCC4 ERCC5 OGG1
12 cellular response to dexamethasone stimulus GO:0071549 9.62 AQP1 TGFB1
13 positive regulation of DNA repair GO:0045739 9.62 MGMT PCNA
14 transcription-coupled nucleotide-excision repair GO:0006283 9.62 ERCC4 ERCC5 LIG1 PCNA
15 nucleotide-excision repair, DNA gap filling GO:0006297 9.61 LIG1 PCNA
16 nucleotide-excision repair, DNA incision, 5-to lesion GO:0006296 9.61 ERCC4 ERCC5 PCNA
17 cell-cell junction organization GO:0045216 9.6 NF2 TGFB1
18 nucleotide-excision repair, DNA incision, 3-to lesion GO:0006295 9.59 ERCC4 ERCC5
19 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.58 ERCC4 ERCC5
20 negative regulation of DNA replication GO:0008156 9.58 NF2 TGFB1
21 mismatch repair GO:0006298 9.58 LIG1 MSH2 PCNA
22 negative regulation of cell-cell adhesion GO:0022408 9.57 NF2 TGFB1
23 lens fiber cell differentiation GO:0070306 9.56 NF2 TGFB1
24 cellular response to DNA damage stimulus GO:0006974 9.56 BRIP1 ERCC4 ERCC5 LIG1 MGMT MSH2
25 UV protection GO:0009650 9.55 ERCC4 ERCC5
26 response to cholesterol GO:0070723 9.52 ABCA2 TGFB1
27 response to folic acid GO:0051593 9.51 MGMT OGG1
28 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MSH2 TGFB1
29 nucleotide-excision repair, DNA incision GO:0033683 9.46 ERCC4 ERCC5 OGG1 PCNA
30 DNA ligation GO:0006266 9.43 LIG1 MGMT PCNA
31 DNA repair GO:0006281 9.23 BRIP1 ERCC4 ERCC5 LIG1 MGMT MSH2

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.76 BRIP1 ERCC4 ERCC5 LIG1 MGMT MSH2
2 protein N-terminus binding GO:0047485 9.61 ERCC4 ERCC5 TGFB1
3 single-stranded DNA binding GO:0003697 9.58 ERCC4 ERCC5 MSH2
4 endonuclease activity GO:0004519 9.54 ERCC4 ERCC5 OGG1
5 endodeoxyribonuclease activity GO:0004520 9.46 ERCC4 ERCC5
6 oxidized purine DNA binding GO:0032357 9.32 MSH2 OGG1
7 MutLalpha complex binding GO:0032405 9.26 MSH2 PCNA
8 dinucleotide insertion or deletion binding GO:0032139 8.96 MSH2 PCNA
9 damaged DNA binding GO:0003684 8.92 ERCC4 MSH2 OGG1 PCNA

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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