MCID: ACS001
MIFTS: 51

Acoustic Neuroma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Acoustic Neuroma

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute of deafness and communication disorders

MalaCards: Acoustic Neuroma, also known as vestibular schwannoma, is related to neuroma and cerebrospinal fluid leak. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Homologous Recombination Repair and Homologous recombination. The compounds camptothecin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are growth/size/body and tumorigenesis.

Wikipedia:66 A vestibular schwannoma, often called an acoustic neuroma, is a benign primary intracranial tumor of the... more...

Aliases & Classifications for Acoustic Neuroma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 35MedlinePlus, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

acoustic neuroma 9 44 11 50 35 63
vestibular schwannoma 9 44 50
acoustic neurilemoma 44 50
acoustic neurinoma 44 50
neurinoma of the acoustic nerve 44
cerebellopontine angle tumor 44
vestibular neurilemmoma 9
neuroma acoustic 46
acoustic tumor 44


External Ids:

Disease Ontology9 DOID:12689
NCIt41 C3276
MeSH36 D009464
SNOMED-CT via Orphanet60 126949007
UMLS via Orphanet64 C0027859

Related Diseases for Acoustic Neuroma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to acoustic neuroma

Symptoms for Acoustic Neuroma

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Drugs & Therapeutics for Acoustic Neuroma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acoustic Neuroma

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Anatomical Context for Acoustic Neuroma

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34MalaCards
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MalaCards organs/tissues related to Acoustic Neuroma:

34
Brain, Testes, Bone, Lung, Eye, B cells, Pituitary, Temporal lobe

Animal Models for Acoustic Neuroma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acoustic Neuroma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0NF2, RAD52, XRCC2, LIG4, AQP4
2MP:00020067.8MUTYH, LIG4, XRCC2, RAD52, NF2
3MP:00036317.4AQP4, MUTYH, LIG4, XRCC2, NF2
4MP:00053767.2RAD52, XRCC2, LIG4, MUTYH, AQP4, NF2
5MP:00107687.1NF2, RAD52, XRCC2, LIG4, MUTYH, AQP4

Publications for Acoustic Neuroma

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53PubMed
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Articles related to Acoustic Neuroma:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Retrosigmoid craniotomy for resection of acoustic neuroma with hearing preservation: a video publication. (24380523)
2014
2
The case of acoustic neuroma: Comment on: Mobile phone use and risk of brain neoplasms and other cancers. (24078153)
2013
3
A case of gastric cancer manifesting as a solitary brain metastasis in the cerebellopontine angle that mimicked acoustic neuroma. (24400217)
2013
4
Recurrent nasopharyngeal carcinoma masquerading as acoustic neuroma. (22434308)
2012
5
Acoustic neuroma neurophysiologic correlates: vestibular-preoperative, intraoperative, and postoperative. (22483818)
2012
6
Acoustic neuroma surgery for preservation of hearing: technique and experience in the Chinese PLA General Hospital. (20406132)
2010
7
Acoustic neuroma identified after electroconvulsive therapy in a patient with recurrent major depression and undifferentiated somatoform disorder. (20357670)
2010
8
Re: Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma. (20447172)
2010
9
Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. (19289391)
2009
10
Future perspectives in acoustic neuroma management. (18810226)
2008
11
Management of unilateral vestibular schwannoma/acoustic neuroma. (18264185)
2007
12
Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. (17414174)
2007
13
Acoustic neuroma in a private neurotology practice: trends in demographics and practice patterns. (17828042)
2007
14
Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. (17019705)
2007
15
Conservative management of acoustic neuroma. (17077873)
2006
16
Counseling patients on surgical options for treating acoustic neuroma. (16005723)
2005
17
Stress hormones in MAcniA"re's disease and acoustic neuroma. (15925138)
2005
18
The prevalence of "incidental" acoustic neuroma. (15781765)
2005
19
Cerebrospinal fluid leak after acoustic neuroma surgery: a comparison of the translabyrinthine, middle fossa, and retrosigmoid approaches. (12544038)
2003
20
Management of unilateral acoustic neuroma in a 72-year-old patient with contralateral congenital deafness. (12447251)
2002
21
Acoustic neuroma surgery and tinnitus. (12115076)
2002
22
Factors affecting recovery after acoustic neuroma resection. (12542203)
2002
23
Symptomatic subdural hygroma and temporal lobe edema after translabyrinthine removal of acoustic neuroma. (17167613)
2001
24
Acoustic neuroma: predominance of Antoni type B cells in tumors of patients with vestibular paresis. (11300272)
2001
25
Cerebrospinal fluid leak after acoustic neuroma surgery: influence of tumor size and surgical approach on incidence and response to treatment. (11213957)
2001
26
Nuances in acoustic neuroma surgery. (11504109)
2001
27
Vasoactive treatment for hearing preservation in acoustic neuroma surgery. (11702866)
2001
28
Consensus meeting on systems for reporting results in acoustic neuroma. November 7-9, 2001. Tokyo, Japan. Abstracts. (11758537)
2001
29
Results of acoustic neuroma radiosurgery: an analysis of 5 years' experience using current methods. (11147876)
2001
30
Impact of facial paralysis on patients with acoustic neuroma. (10983957)
2000
31
Evaluation of three intraoperative auditory monitoring techniques in acoustic neuroma surgery. (10733192)
2000
32
Acoustic neuroma: outcome of surgical resection and study on the anatomy of facial and cochlear nerves. (10575527)
1999
33
Management of acoustic neuroma. (10206835)
1999
34
Stereocilia-like structures in the endolymphatic sac in MAcniA"re's disease and acoustic neuroma. (9892873)
1999
35
Suboccipital resection of a medial acoustic neuroma with hearing preservation. (10321887)
1999
36
General anesthesia with remifentanil for Cesarean section in a parturient with an acoustic neuroma. (10391607)
1999
37
Endoscopy of the posterior fossa and endoscopic dissection of acoustic neuroma. (16681355)
1999
38
Spinal subdural hematoma after resection of an acoustic neuroma. (10187952)
1999
39
Disability from vestibular symptoms after acoustic neuroma resection. (9455958)
1998
40
Acoustic neuroma presenting as orofacial anethesia. (11507494)
1998
41
Intra-operative monitoring in acoustic neuroma surgery. (9785586)
1998
42
Pneumocephalus after acoustic neuroma surgery. (9831162)
1998
43
Stereotactic radiosurgery for acoustic neuroma: a Canadian perspective. (9827233)
1998
44
A rare case of acoustic neuroma extending from the cerebellopontine angle to the external auditory canal. (18644299)
1998
45
Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention. (9202266)
1997
46
Individualizing hearing preservation in acoustic neuroma surgery. (9261005)
1997
47
Sensorineural hearing loss and cerebellopontine angle lesions. Not always an acoustic neuroma--a pictorial essay. (9156313)
1997
48
Unilateral acoustic neuroma in childhood. (9148735)
1997
49
Surgical treatment of acoustic neuroma (vestibular schwannoma) in the United States: report from the Acoustic Neuroma Registry. (8544629)
1996
50
Ramsay Hunt syndrome mimicking acoustic neuroma on MRI. (7499937)
1995

Variations for Acoustic Neuroma

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Expression for genes affiliated with Acoustic Neuroma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acoustic Neuroma

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Pathways for genes affiliated with Acoustic Neuroma

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Acoustic Neuroma

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46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB
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Compounds related to Acoustic Neuroma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1camptothecin46 62 1211.1RAD52, XRCC2
2cyclophosphamide46 52 1211.1RAD52, MUTYH
3cisplatin46 52 62 1211.5RAD52, XRCC2, MUTYH

GO Terms for genes affiliated with Acoustic Neuroma

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17Gene Ontology
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Biological processes related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:0101659.6XRCC2, LIG4
2positive regulation of neurogenesisGO:0507699.6XRCC2, LIG4
3response to gamma radiationGO:0103329.5LIG4, XRCC2
4negative regulation of neuron apoptotic processGO:0435249.5XRCC2, LIG4
5double-strand break repair via homologous recombinationGO:0007249.3RAD52, XRCC2
6double-strand break repairGO:0063029.2RAD52, LIG4
7DNA repairGO:0062818.3RAD52, XRCC2, LIG4, MUTYH

Molecular functions related to Acoustic Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.4NF2, RAD52, ZNF350, XRCC2, LIG4, MUTYH

Products for genes affiliated with Acoustic Neuroma

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  • Antibodies
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  • Antibodies

Sources for Acoustic Neuroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet