MCID: ACS001
MIFTS: 60

Acoustic Neuroma malady

Neuronal diseases, Cancer diseases categories

Summaries for Acoustic Neuroma

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute of deafness and communication disorders

MalaCards: Acoustic Neuroma, also known as vestibular schwannoma, is related to meningioma and facial paralysis. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Cytosolic Iron-sulfur Cluster Assembly. The compounds l189 and phosphodiester have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:63 A vestibular schwannoma, often called an acoustic neuroma, is a benign primary intracranial tumor of the... more...

Aliases & Classifications for Acoustic Neuroma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

acoustic neuroma 8 42 10 48 33 60
vestibular schwannoma 8 48
acoustic neurilemoma 42 48
acoustic neurinoma 42 48
neurinoma of the acoustic nerve 42
cerebellopontine angle tumor 42
vestibular neurilemmoma 8
neuroma acoustic 44
acoustic tumor 42


External Ids:

Disease Ontology8 DOID:12689
MeSH34 D009464
NCIt39 C3276
SNOMED-CT via Orphanet57 126949007

Related Diseases for Acoustic Neuroma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to acoustic neuroma

Clinical Features for Acoustic Neuroma

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Drugs & Therapeutics for Acoustic Neuroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acoustic Neuroma

Search CenterWatch for Acoustic Neuroma

Genetic Tests for Acoustic Neuroma

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Anatomical Context for Acoustic Neuroma

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32MalaCards
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MalaCards organs/tissues related to Acoustic Neuroma:

32
Brain, Testes, Bone, Eye, Lung, B cells, Pituitary, Temporal lobe

Animal Models for Acoustic Neuroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acoustic Neuroma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4NF2, LIG1
2MP:001077110.1XRCC2, XPC, LIG1, POLB
3MP:00036319.8CRLF1, LIG4, SSTR1, NF2, MUTYH, RTEL1
4MP:00053809.6XRCC2, LIG1, NF2, POLB, FKBP4, RAD23B
5MP:00053869.6CRLF1, LIG4, SSTR1, NF2, POLB, RAD23B
6MP:00053709.6LIG4, LIG1, NF2, POLB, ERCC4, ERCC5
7MP:00053849.2XRCC2, XPC, LIG4, LIG1, SSTR1, POLB
8MP:00053789.2POLB, NF2, LIG1, LIG4, XPC, XRCC2
9MP:00053769.1NF2, SSTR1, LIG1, LIG4, XPC, XRCC2
10MP:00107689.0ERCC2, XRCC2, XPC, CRLF1, LIG4, LIG1

Publications for Acoustic Neuroma

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50PubMed
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Articles related to Acoustic Neuroma:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
A case of gastric cancer manifesting as a solitary brain metastasis in the cerebellopontine angle that mimicked acoustic neuroma. (24400217)
2013
2
Acoustic neuroma observation associated with an increase in symptomatic tinnitus: results of the 2007-2008 Acoustic Neuroma Association survey. (23790115)
2013
3
You're the flight surgeon. Acoustic neuroma. (22946361)
2012
4
Retromastoid-sub occipital: A novel approach to cerebello pontine angle in acoustic neuroma surgery-our experience in 21 cases. (21716801)
2011
5
Gait instability in patients with small acoustic neuroma. (21740788)
2011
6
A case-case study of mobile phone use and acoustic neuroma risk in Japan. (21225885)
2011
7
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. (20150366)
2010
8
Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery. (21359005)
2010
9
Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report. (18549411)
2009
10
Management of unilateral vestibular schwannoma/acoustic neuroma. (18264185)
2007
11
Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. (17414174)
2007
12
Balance impairment after acoustic neuroma surgery. (17948359)
2007
13
Acoustic neuroma (vestibular schwannoma): surgical results on 240 patients operated on dorsal decubitus position. (17876399)
2007
14
Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. (17079691)
2007
15
Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. (15744156)
2005
16
Postural stability of preoperative acoustic neuroma patients assessed by sway magnetometry: are they unsteady? (12671420)
2003
17
Self-assessed quality of life after acoustic neuroma surgery. (14609159)
2003
18
Distal mycotic aneurysm of the AICA mimicking intracanalicular acoustic neuroma. (14672274)
2003
19
Facial motion analysis with a video and computer system after treatment of acoustic neuroma. (12170163)
2002
20
Distance from acoustic neuroma to fundus and a postoperative facial palsy. (11802057)
2002
21
Hearing preservation in acoustic neuroma surgery: the impact of different patient selection criteria. (12439179)
2002
22
Vestibular function after acoustic neuroma removal with preservation of one branch of the vestibular nerve. (12218629)
2002
23
Symptomatic subdural hygroma and temporal lobe edema after translabyrinthine removal of acoustic neuroma. (17167613)
2001
24
Vasoactive treatment for hearing preservation in acoustic neuroma surgery. (11702866)
2001
25
Intracochlea acoustic neuroma: a case report and discussion. (11829196)
2001
26
Electromyographic evaluation of facial nerve damage in acoustic neuroma surgery. (11449116)
2001
27
A modified retrosigmoid approach for direct exposure of the fundus of the internal auditory canal for hearing preservation in acoustic neuroma surgery. (10651442)
2000
28
Short-term antibiotic prophylaxis for the prevention of wound infection and secondary meningitis in acoustic neuroma surgery: a ten-year experience in a regional hospital. (11154037)
2000
29
Three-dimensional imaging of the internal auditory canal in patients with acoustic neuroma. (10897391)
2000
30
Acuteness of preoperative factors to predict hearing preservation in acoustic neuroma surgery. (10646731)
2000
31
Fractionated stereotactic radiation therapy and single high-dose radiosurgery for acoustic neuroma: early results of a prospective clinical study. (10656371)
2000
32
Normal audiologic presentations in patients with acoustic neuroma: An evaluation using strict audiologic parameters. (10652383)
2000
33
Endoscopy of the posterior fossa and endoscopic dissection of acoustic neuroma. (16681355)
1999
34
Is there still a role for auditory brainstem response audiometry in the diagnosis of acoustic neuroma? (10037293)
1999
35
Vascular compression of the cochlear nerve identified by endoscopy during acoustic neuroma surgery. (10187950)
1999
36
Comparison of different wound closure techniques in translabyrinthine acoustic neuroma surgery. (17171111)
1999
37
Is the presence of transient evoked otoacoustic emmissions in ears with acoustic neuroma significant? (9546278)
1998
38
Ultra high resolution nonenhanced fast spin echo magnetic resonance imaging: cost-effective screening for acoustic neuroma in patients with sudden sensorineural hearing loss. (9781992)
1998
39
A case of pneumocephalus secondary to VP shunt in a patient with acoustic neuroma. (18639019)
1998
40
Non-acoustic neuroma tumor (NANT) of the cerebello-pontine angle: a 15-year experience. (9385566)
1997
41
Intraoperative monitoring of facial nerve antidromic potentials during acoustic neuroma surgery. (9349860)
1997
42
Acoustic neuroma surgery: outcome analysis of patient-perceived disability. (9233481)
1997
43
Management of the contracted mastoid in the translabyrinthine removal of acoustic neuroma. (9076243)
1997
44
MR imaging of acoustic neuroma with high resolution fast spin echo T2-weighted sequence. (9056152)
1997
45
Direct cochlear nerve action potentials as an aid to hearing preservation in middle fossa acoustic neuroma resection. (8841717)
1996
46
Evolution of the management of hydrocephalus associated with acoustic neuroma. (8583854)
1996
47
Hypoglossal-facial nerve anastomosis after acoustic neuroma resection: influence of the time anastomosis on recovery of facial movement. (8718535)
1996
48
Treating the oral sequelae of an acoustic neuroma. (8682992)
1996
49
Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. (8217082)
1993
50
Diagnosis of middle ear disease and acoustic neuroma. (6859244)
1983

Genetic Variations for Acoustic Neuroma

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Expression for genes affiliated with Acoustic Neuroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for genes affiliated with Acoustic Neuroma

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Sources:
53Reactome, 49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3RAD23B, XPC
210.3ERCC2, RTEL1
3
Hide members
10.3MUTYH, POLB
410.2ERCC2, XRCC3
5
Hide members
10.2RAD52, RAD51
6
Hide members
10.2LIG1, POLB, MUTYH
7
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.1RAD51, POLB, XPC
8
Hide members
10.1ERCC4, ERCC5, ERCC2
9
Hide members
10.0RAD52, RAD51, XRCC2, XRCC3
10
Hide members
10.0LIG4, LIG1, RAD51, RAD52
11
Hide members
9.9XPC, MUTYH, RAD51, RAD52, ERCC2
12
Hide members
9.7XPC, LIG4, LIG1, RAD23B, ERCC4, ERCC5
13
Hide members
9.5XPC, LIG4, LIG1, POLB, RAD23B, RAD51
14
Hide members
9.2ERCC2, XPC, LIG4, LIG1, POLB, MUTYH

Compounds for genes affiliated with Acoustic Neuroma

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Sources:
59Tocris Bioscience, 44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 11DrugBank
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Compounds related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1l1895910.5LIG1, LIG4
2phosphodiester4410.5ERCC5, POLB, LIG1
38-oxo-dg4410.5LIG1, POLB, MUTYH
48-oxo-dgtp44 2411.4MUTYH, POLB
5aphidicolin4410.4RAD51, POLB, LIG1
6sugar phosphate4410.4RAD51, POLB
7polynucleotide4410.4RAD51, POLB, LIG1, LIG4
8thymine44 2411.4RAD51, POLB, XPC
9thymine glycol4410.4POLB, ERCC5
10methylmethanesulfonate4410.3POLB, RAD51, RAD52
11caffeine44 49 28 2 11 2415.3RAD51, LIG1, XRCC2, XRCC3
12camptothecin44 59 1112.3XRCC3, XRCC2, RAD51, RAD52
13ecteinascidin 7434410.3ERCC2, ERCC5
14thymidylate4410.3POLB, RAD51, ERCC4, ERCC2
15mitomycin c4410.3XRCC3, XRCC2, POLB, RAD51, ERCC4
16melphalan44 1111.2XRCC3, POLB, RAD51, ERCC4, ERCC2
17adenine44 11 2412.1RAD51, MUTYH, POLB
188-oxoguanine4410.0MUTYH, POLB
19oligonucleotide449.8XPC, LIG1, POLB, RAD51, ERCC5
20atp44 2810.8XPC, LIG1, POLB, FKBP4, RAD51, ERCC5
21cisplatin44 49 59 1112.7ERCC2, XRCC3, XRCC2, XPC, LIG1, POLB

GO Terms for genes affiliated with Acoustic Neuroma

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16Gene Ontology
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Cellular components related to Acoustic Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.3RAD23B, XPC
2condensed chromosomeGO:00079310.3RAD51, LIG4
3holo TFIIH complexGO:0056759.9ERCC2, ERCC5
4nucleoplasmGO:0056549.3ERCC2, XPC, LIG4, LIG1, POLB, MUTYH
5cytoplasmGO:0057379.1LIG4, CRLF1, XPC, XRCC3, SSTR1, NF2
6nucleusGO:0056348.7POLB, NF2, LIG1, LIG4, XPC, XRCC2

Biological processes related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.6XPC, RAD23B
2nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.5ERCC4, ERCC5
3lagging strand elongationGO:00627310.5LIG4, LIG1
4regulation of mitotic cell cycle phase transitionGO:190199010.5XPC, ERCC2
5nucleotide-excision repair, DNA gap fillingGO:00629710.5POLB, LIG1, LIG4
6nucleotide-excision repair, DNA incisionGO:03368310.5ERCC4, ERCC2
7DNA recombinase assemblyGO:00073010.4RAD52, RAD51
8base-excision repairGO:00628410.4MUTYH, POLB, LIG1
9UV protectionGO:00965010.4ERCC2, ERCC5, ERCC4
10DNA ligation involved in DNA repairGO:05110310.4LIG1, LIG4
11mitotic recombinationGO:00631210.4RAD52, RAD51
12V(D)J recombinationGO:03315110.4LIG4, LIG1
13telomere maintenanceGO:00072310.4LIG1, RTEL1, ERCC4
14double-strand break repairGO:00630210.4LIG4, LIG1, RAD51, RAD52
15transcription-coupled nucleotide-excision repairGO:00628310.3LIG1, ERCC4, ERCC5, ERCC2
16regulation of double-strand break repair via homologous recombinationGO:01056910.3RTEL1, RAD51
17positive regulation of neurogenesisGO:05076910.3LIG4, XRCC2
18double-strand break repair via homologous recombinationGO:00072410.3XRCC2, LIG1, RAD51, RAD52, ERCC4
19nucleotide-excision repair, DNA damage removalGO:00071810.3XPC, RAD23B, ERCC4, ERCC5, ERCC2
20negative regulation of neuron apoptotic processGO:04352410.2XRCC2, CRLF1, LIG4
21double-strand break repair via nonhomologous end joiningGO:00630310.2LIG1, LIG4
22nucleotide-excision repairGO:00628910.1XPC, LIG1, RAD23B, ERCC4, ERCC5, ERCC2
23response to X-rayGO:01016510.0LIG4, XRCC2
24DNA repairGO:0062819.3ERCC2, XRCC3, XRCC2, XPC, LIG4, LIG1

Molecular functions related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
2DNA ligase activityGO:00390910.5LIG4, LIG1
3DNA-dependent ATPase activityGO:00809410.4ERCC2, XRCC2, XRCC3
44 iron, 4 sulfur cluster bindingGO:05153910.3ERCC2, RTEL1, MUTYH
5bubble DNA bindingGO:00040510.3XPC, ERCC5
6damaged DNA bindingGO:00368410.2ERCC4, RAD51, RAD23B, POLB, XPC
7single-stranded DNA bindingGO:00369710.2XPC, RAD23B, RAD51, ERCC4, ERCC5
8protein C-terminus bindingGO:00802210.1LIG4, RAD51, ERCC4, ERCC2
9protein N-terminus bindingGO:04748510.1ERCC2, ERCC5, ERCC4
10endodeoxyribonuclease activityGO:0045209.9ERCC5, ERCC4
11ATP bindingGO:0055249.8XRCC3, XRCC2, LIG4, LIG1, FKBP4, RAD51
12DNA bindingGO:0036779.7XRCC3, XRCC2, LIG4, LIG1, RAD52, RTEL1
13metal ion bindingGO:0468729.5LIG4, LIG1, POLB, MUTYH, RTEL1, ZNF350
14protein bindingGO:0055158.9POLB, NF2, LIG4, CRLF1, XPC, XRCC2

Products for genes affiliated with Acoustic Neuroma

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  • Antibodies
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Sources for Acoustic Neuroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet