MCID: ACS001
MIFTS: 60

Acoustic Neuroma malady

Neuronal diseases, Cancer diseases categories

Summaries for Acoustic Neuroma

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute of deafness and communication disorders

MalaCards: Acoustic Neuroma, also known as vestibular schwannoma, is related to meningioma and facial paralysis. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Cytosolic Iron-sulfur Cluster Assembly. The compounds l189 and phosphodiester have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:63 A vestibular schwannoma, often called an acoustic neuroma, is a benign primary intracranial tumor of the... more...

Aliases & Classifications for Acoustic Neuroma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 44Novoseek, 34MeSH, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

acoustic neuroma 8 42 10 48 33 60
vestibular schwannoma 8 48
acoustic neurilemoma 42 48
acoustic neurinoma 42 48
neurinoma of the acoustic nerve 42
cerebellopontine angle tumor 42
vestibular neurilemmoma 8
neuroma acoustic 44
acoustic tumor 42


External Ids:

Disease Ontology8 DOID:12689
MeSH34 D009464
NCIt39 C3276
SNOMED-CT via Orphanet57 126949007

Related Diseases for Acoustic Neuroma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to acoustic neuroma

Clinical Features for Acoustic Neuroma

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Drugs & Therapeutics for Acoustic Neuroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acoustic Neuroma

Search CenterWatch for Acoustic Neuroma

Genetic Tests for Acoustic Neuroma

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Anatomical Context for Acoustic Neuroma

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32MalaCards
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MalaCards organs/tissues related to Acoustic Neuroma:

32
Brain, Testes, Bone, Eye, Lung, B cells, Pituitary, Temporal lobe

Animal Models for Acoustic Neuroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acoustic Neuroma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4LIG1, NF2
2MP:001077110.1XPC, XRCC2, LIG1, POLB
3MP:00036319.8CRLF1, RTEL1, MUTYH, NF2, LIG4, SSTR1
4MP:00053809.6NF2, RTEL1, RAD51, RAD23B, FKBP4, POLB
5MP:00053869.6NF2, RAD23B, ERCC2, SSTR1, LIG4, CRLF1
6MP:00053709.6NF2, POLB, ERCC4, LIG1, ERCC5, LIG4
7MP:00053849.2POLB, RAD23B, ERCC4, MUTYH, RAD52, SSTR1
8MP:00053789.2RAD51, ERCC2, FKBP4, ERCC5, ERCC4, RTEL1
9MP:00053769.1SSTR1, LIG1, LIG4, XPC, XRCC2, NF2
10MP:00107689.0FKBP4, ERCC4, ERCC5, RAD52, RAD51, RAD23B

Publications for Acoustic Neuroma

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50PubMed
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Articles related to Acoustic Neuroma:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Retrosigmoid craniotomy for resection of acoustic neuroma with hearing preservation: a video publication. (24380523)
2014
2
The safe zone of posterior semicircular canal resection in suboccipital retrosigmoid sinus approach for acoustic neuroma surgery. (24220416)
2013
3
Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh-hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma. (23350781)
2013
4
Validating the Penn Acoustic Neuroma Quality Of Life Scale in a sample of Dutch patients recently diagnosed with vestibular schwannoma. (23714709)
2013
5
Expression of p63 and p73 in acoustic neuroma and its possible clinical relevance. (22000483)
2012
6
Factors associated with anxiety and depression in the management of acoustic neuroma patients. (22051029)
2012
7
Audiometric outcomes for acoustic neuroma patients after single versus multiple fraction stereotactic irradiation. (21192276)
2011
8
Acoustic neuroma surgery for preservation of hearing: technique and experience in the Chinese PLA General Hospital. (20406132)
2010
9
Magnetic resonance imaging screening in acoustic neuroma. (20015748)
2010
10
Cell phone use and acoustic neuroma: the need for standardized questionnaires and access to industry data. (19328527)
2009
11
Predictors of hearing preservation after stereotactic radiosurgery for acoustic neuroma. (19284227)
2009
12
An integrated diffusion map for the analysis of diffusion properties: a feasibility study in patients with acoustic neuroma. (19268854)
2009
13
Acoustic neuroma presenting with a resting tremor. (17994589)
2008
14
Selection of surgical approach to acoustic neuroma. 1992. (18534336)
2008
15
Comparing size evaluation methods for acoustic neuroma after stereotactic radiosurgery. (17705004)
2007
16
INTERESTING CASE: acoustic neuroma--an unusual presentation. (16309802)
2006
17
Mobile phone use and risk of acoustic neuroma. (16570041)
2006
18
Acquired port-wine stain related to acoustic neuroma. (16309474)
2006
19
Metastatic lung cancer in the cerebellopontine angles mimicking bilateral acoustic neuroma. (15749427)
2005
20
Dissemination of fat in CSF: a common finding following translabyrinthine acoustic neuroma surgery*. (16232242)
2005
21
Acoustic neuroma radiosurgery. Origins, contemporary use and future expectations. (15179299)
2004
22
Meningitis due to Enterobacter aerogenes subsequent to resection of acoustic neuroma and percutaneous endoscopic gastrostomy tube placement: a rare nosocomial event. (14587946)
2003
23
Classic hypoglossal-facial nerve anastomosis after acoustic neuroma resection. A review of 46 cases. (12624499)
2003
24
Results of acoustic neuroma radiosurgery: an analysis of 5 years' experience using current methods. (11147876)
2001
25
Hearing preservation in acoustic neuroma surgery. (11771026)
2001
26
Relationship between cystic change and rotatory vertigo in patients with acoustic neuroma. (10897392)
2000
27
Acoustic neuroma surgery as an interdisciplinary approach. (10896683)
2000
28
Recurrence of acoustic neuroma after incomplete resection. (10821553)
2000
29
Acoustic neuroma--surgery or radiosurgery? (11279355)
2000
30
Acoustic neuroma: postoperative quality of life. (11770141)
2000
31
Long-term results of facial nerve function after acoustic neuroma surgery--clinical benefit of intraoperative facial nerve monitoring. (11291286)
2000
32
Management of acoustic neuroma. (10206835)
1999
33
Suboccipital resection of a medial acoustic neuroma with hearing preservation. (10321887)
1999
34
General anesthesia with remifentanil for Cesarean section in a parturient with an acoustic neuroma. (10391607)
1999
35
Observation versus early stereotactic radiotherapy of acoustic neuroma: what are you waiting for? (10348274)
1999
36
Headache after resection of acoustic neuroma. (15613200)
1999
37
Postoperative magnetic resonance imaging after acoustic neuroma surgery: influence of packing materials in the drilled internal auditory canal on assessment of residual tumor. (10193147)
1999
38
Adjunctive use of endoscopy during acoustic neuroma surgery. (10443819)
1999
39
Necrotizing granulomatous inflammation of the superior vestibular nerve mimicking an acoustic neuroma. (9627252)
1998
40
Images in clinical medicine. Acoustic neuroma (vestibular schwannoma). (9811919)
1998
41
Role of transient-evoked otoacoustic emissions for hearing preservation in acoustic neuroma surgery. (9391671)
1997
42
Pain after acoustic neuroma surgery. (9295259)
1997
43
Temporal bone pathology of acoustic neuroma correlating with presence of electrocochleography and absence of auditory brainstem response. (9425489)
1997
44
Acoustic neuroma and twin pregnancy. (9286868)
1997
45
Middle ear mucocele: an unusual complication of the tranlabyrinthine approach to acoustic neuroma. (17171032)
1997
46
Brain stem implantable electrodes in management of total deafness after removal of acoustic neuroma--a review of operative approaches. (9243941)
1996
47
Acoustic neuroma recurrence after suboccipital resection: management with translabyrinthine resection. (8723967)
1996
48
Iatrogenic impairment of hearing during surgery for acoustic neuroma. (17170972)
1996
49
The best treatment for vestibular schwannoma (acoustic neuroma): microsurgery or radiosurgery? (8841720)
1996
50
Cerebrospinal fluid leak after translabyrinthine surgery for acoustic neuroma. (3974394)
1985

Genetic Variations for Acoustic Neuroma

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Expression for genes affiliated with Acoustic Neuroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for genes affiliated with Acoustic Neuroma

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Sources:
53Reactome, 49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3RAD23B, XPC
210.3ERCC2, RTEL1
3
Hide members
10.3MUTYH, POLB
410.2ERCC2, XRCC3
5
Hide members
10.2RAD52, RAD51
6
Hide members
10.2LIG1, POLB, MUTYH
7
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.1RAD51, POLB, XPC
8
Hide members
10.1ERCC4, ERCC5, ERCC2
9
Hide members
10.0RAD52, RAD51, XRCC2, XRCC3
10
Hide members
10.0LIG4, LIG1, RAD51, RAD52
11
Hide members
9.9XPC, MUTYH, RAD51, RAD52, ERCC2
12
Hide members
9.7XPC, LIG4, LIG1, RAD23B, ERCC4, ERCC5
13
Hide members
9.5XPC, LIG4, LIG1, POLB, RAD23B, RAD51
14
Hide members
9.2ERCC2, XPC, LIG4, LIG1, POLB, MUTYH

Compounds for genes affiliated with Acoustic Neuroma

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Sources:
59Tocris Bioscience, 44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 11DrugBank
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Compounds related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1l1895910.5LIG1, LIG4
2phosphodiester4410.5ERCC5, POLB, LIG1
38-oxo-dg4410.5LIG1, POLB, MUTYH
48-oxo-dgtp44 2411.4MUTYH, POLB
5aphidicolin4410.4RAD51, POLB, LIG1
6sugar phosphate4410.4RAD51, POLB
7polynucleotide4410.4RAD51, POLB, LIG1, LIG4
8thymine44 2411.4RAD51, POLB, XPC
9thymine glycol4410.4POLB, ERCC5
10methylmethanesulfonate4410.3POLB, RAD51, RAD52
11caffeine44 49 28 2 11 2415.3RAD51, LIG1, XRCC2, XRCC3
12camptothecin44 59 1112.3XRCC3, XRCC2, RAD51, RAD52
13ecteinascidin 7434410.3ERCC2, ERCC5
14thymidylate4410.3POLB, RAD51, ERCC4, ERCC2
15mitomycin c4410.3XRCC3, XRCC2, POLB, RAD51, ERCC4
16melphalan44 1111.2XRCC3, POLB, RAD51, ERCC4, ERCC2
17adenine44 11 2412.1RAD51, MUTYH, POLB
188-oxoguanine4410.0MUTYH, POLB
19oligonucleotide449.8XPC, LIG1, POLB, RAD51, ERCC5
20atp44 2810.8XPC, LIG1, POLB, FKBP4, RAD51, ERCC5
21cisplatin44 49 59 1112.7ERCC2, XRCC3, XRCC2, XPC, LIG1, POLB

GO Terms for genes affiliated with Acoustic Neuroma

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16Gene Ontology
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Cellular components related to Acoustic Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.3RAD23B, XPC
2condensed chromosomeGO:00079310.3RAD51, LIG4
3holo TFIIH complexGO:0056759.9ERCC2, ERCC5
4nucleoplasmGO:0056549.3ERCC2, XPC, LIG4, LIG1, POLB, MUTYH
5cytoplasmGO:0057379.1LIG4, CRLF1, XPC, XRCC3, SSTR1, NF2
6nucleusGO:0056348.7POLB, NF2, LIG1, LIG4, XPC, XRCC2

Biological processes related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.6XPC, RAD23B
2nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.5ERCC4, ERCC5
3lagging strand elongationGO:00627310.5LIG4, LIG1
4regulation of mitotic cell cycle phase transitionGO:190199010.5XPC, ERCC2
5nucleotide-excision repair, DNA gap fillingGO:00629710.5POLB, LIG1, LIG4
6nucleotide-excision repair, DNA incisionGO:03368310.5ERCC4, ERCC2
7DNA recombinase assemblyGO:00073010.4RAD52, RAD51
8base-excision repairGO:00628410.4MUTYH, POLB, LIG1
9UV protectionGO:00965010.4ERCC2, ERCC5, ERCC4
10DNA ligation involved in DNA repairGO:05110310.4LIG1, LIG4
11mitotic recombinationGO:00631210.4RAD52, RAD51
12V(D)J recombinationGO:03315110.4LIG4, LIG1
13telomere maintenanceGO:00072310.4LIG1, RTEL1, ERCC4
14double-strand break repairGO:00630210.4LIG4, LIG1, RAD51, RAD52
15transcription-coupled nucleotide-excision repairGO:00628310.3LIG1, ERCC4, ERCC5, ERCC2
16regulation of double-strand break repair via homologous recombinationGO:01056910.3RTEL1, RAD51
17positive regulation of neurogenesisGO:05076910.3LIG4, XRCC2
18double-strand break repair via homologous recombinationGO:00072410.3XRCC2, LIG1, RAD51, RAD52, ERCC4
19nucleotide-excision repair, DNA damage removalGO:00071810.3XPC, RAD23B, ERCC4, ERCC5, ERCC2
20negative regulation of neuron apoptotic processGO:04352410.2XRCC2, CRLF1, LIG4
21double-strand break repair via nonhomologous end joiningGO:00630310.2LIG1, LIG4
22nucleotide-excision repairGO:00628910.1XPC, LIG1, RAD23B, ERCC4, ERCC5, ERCC2
23response to X-rayGO:01016510.0LIG4, XRCC2
24DNA repairGO:0062819.3ERCC2, XRCC3, XRCC2, XPC, LIG4, LIG1

Molecular functions related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
2DNA ligase activityGO:00390910.5LIG4, LIG1
3DNA-dependent ATPase activityGO:00809410.4ERCC2, XRCC2, XRCC3
44 iron, 4 sulfur cluster bindingGO:05153910.3ERCC2, RTEL1, MUTYH
5bubble DNA bindingGO:00040510.3XPC, ERCC5
6damaged DNA bindingGO:00368410.2ERCC4, RAD51, RAD23B, POLB, XPC
7single-stranded DNA bindingGO:00369710.2XPC, RAD23B, RAD51, ERCC4, ERCC5
8protein C-terminus bindingGO:00802210.1LIG4, RAD51, ERCC4, ERCC2
9protein N-terminus bindingGO:04748510.1ERCC2, ERCC5, ERCC4
10endodeoxyribonuclease activityGO:0045209.9ERCC5, ERCC4
11ATP bindingGO:0055249.8XRCC3, XRCC2, LIG4, LIG1, FKBP4, RAD51
12DNA bindingGO:0036779.7XRCC3, XRCC2, LIG4, LIG1, RAD52, RTEL1
13metal ion bindingGO:0468729.5LIG4, LIG1, POLB, MUTYH, RTEL1, ZNF350
14protein bindingGO:0055158.9POLB, NF2, LIG4, CRLF1, XPC, XRCC2

Products for genes affiliated with Acoustic Neuroma

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  • Antibodies
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Sources for Acoustic Neuroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet