MCID: ACS001
MIFTS: 58

Acoustic Neuroma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Acoustic Neuroma

Aliases & Descriptions for Acoustic Neuroma:

Name: Acoustic Neuroma 12 50 56 41 14 69
Vestibular Schwannoma 12 50 56 29
Cerebellopontine Angle Tumor 50 69
Acoustic Neurilemoma 50 56
Acoustic Neurinoma 50 56
Neurinoma of the Acoustic Nerve 50
Vestibular Neurilemmoma 12
Neuroma, Acoustic 42
Neuroma Acoustic 52
Acoustic Tumor 50

Characteristics:

Orphanet epidemiological data:

56
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 42 D009464
NCIt 47 C3276
Orphanet 56 ORPHA252175
UMLS via Orphanet 70 C0027859
ICD10 via Orphanet 34 D33.3
UMLS 69 C0027859

Summaries for Acoustic Neuroma

MedlinePlus : 41 an acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute on deafness and communication disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to cerebellopontine angle tumor and neurofibromatosis, and has symptoms including back pain, coughing and headache. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)

Wikipedia : 71 A vestibular schwannoma is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 cerebellopontine angle tumor 12.3
2 neurofibromatosis 12.0
3 neurofibromatosis, type 2 11.5
4 neuroma 11.1
5 neurofibromatosis, type 1 11.0
6 schwannomatosis 10.9
7 cerebrospinal fluid leak 10.2
8 headache 10.2
9 benign paroxysmal positional nystagmus 10.2 NF2 TGFB1
10 childhood brainstem astrocytoma 10.1 AQP1 AQP4
11 progesterone resistance 10.1 NBN PCNA
12 ehlers-danlos syndrome, kyphoscoliotic form 10.1 AQP1 AQP4
13 common bile duct neoplasm 10.1 NF2 PCNA
14 facial paralysis 10.1
15 superior vena cava syndrome 10.1 AQP1 AQP4
16 meningitis 10.1
17 hydrocephalus 10.0
18 glioma 10.0
19 connective tissue cancer 10.0 AQP4 NF2 PCNA TGFB1
20 glioblastoma 10.0
21 sensorineural hearing loss 10.0
22 aneurysm 10.0
23 t-cell large granular lymphocyte leukemia 9.9 ERCC5 MSH2 NF2
24 amyloid tumor 9.9 MGMT PCNA
25 herpes simplex 9.9
26 arachnoiditis 9.9
27 glioblastoma multiforme 9.9
28 cerebritis 9.9
29 mastoiditis 9.9
30 intracranial aneurysm 9.7
31 neuronitis 9.7
32 occipital neuralgia 9.7
33 lung cancer 9.7
34 pulmonary edema 9.7
35 pituitary tumors 9.7
36 otitis media 9.7
37 cholesteatoma 9.7
38 tremor 9.7
39 costello syndrome 9.7
40 otosclerosis 9.7
41 neuropathy 9.7
42 whiplash 9.7
43 nasopharyngeal carcinoma 9.7
44 vestibular neuronitis 9.7
45 communicating hydrocephalus 9.7
46 encephalitis 9.7
47 neurofibroma 9.7
48 trigeminal neuralgia 9.7
49 meniere's disease 9.7
50 cataract 9.7

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


back pain, coughing, headache, pain, sciatica, seizures, snoring, syncope, tremor, chronic pain, sore throat, vertigo/dizziness, equilibration disorder, sleeplessness

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.43 LIG1 MGMT MSH2 NBN PARP1 PCNA
2 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.33 MSH2 NBN PCNA
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 AQP1 LIG1 NBN PCNA TGFB1
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 AQP1 LIG1 NBN PCNA TGFB1

MGI Mouse Phenotypes related to Acoustic Neuroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 ABCA2 AQP1 AQP4 ERCC5 LIG1 NBN
2 homeostasis/metabolism MP:0005376 10.11 ABCA2 AQP1 AQP4 ERCC5 LIG1 MGMT
3 endocrine/exocrine gland MP:0005379 10.06 AQP1 AQP4 LIG1 MGMT NBN NF2
4 hematopoietic system MP:0005397 10.06 AQP1 AQP4 ERCC5 LIG1 MSH2 NBN
5 mortality/aging MP:0010768 10.03 ABCA2 AQP1 AQP4 ERCC5 LIG1 MGMT
6 immune system MP:0005387 9.97 AQP4 ERCC5 LIG1 MSH2 NBN NF2
7 neoplasm MP:0002006 9.63 MGMT MSH2 NBN NF2 TGFB1 LIG1
8 nervous system MP:0003631 9.56 TGFB1 ABCA2 AQP1 AQP4 MSH2 NBN
9 reproductive system MP:0005389 9.17 ABCA2 AQP1 NBN NF2 PARP1 PCNA

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Early Phase 1
2 Anti-Infective Agents Phase 4,Phase 2,Early Phase 1
3 Gentamicins Phase 4
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6 Antiemetics Phase 3
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Antineoplastic Agents, Hormonal Phase 3
9 Autonomic Agents Phase 3
10 Gastrointestinal Agents Phase 3
11 glucocorticoids Phase 3
12 Hormone Antagonists Phase 3
13 Hormones Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Methylprednisolone acetate Phase 3
16 Methylprednisolone Hemisuccinate Phase 3
17 Neuroprotective Agents Phase 3
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Prednisolone acetate Phase 3
20 Prednisolone hemisuccinate Phase 3
21 Prednisolone phosphate Phase 3
22 Protective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 5284616 6436030 46835353
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
30 Protein Kinase Inhibitors Phase 2,Early Phase 1
31 Angiogenesis Inhibitors Phase 2,Phase 1
32 Angiogenesis Modulating Agents Phase 2,Phase 1
33 Antibodies Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunoglobulins Phase 2
36 Antibiotics, Antitubercular Phase 2,Early Phase 1
37 Antifungal Agents Phase 2,Early Phase 1
38 Immunosuppressive Agents Phase 2,Early Phase 1
39 Endostatins Phase 2 71581480
40
Lactitol Phase 2 585-86-4 3871
41 Analgesics Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 2
44 Antipyretics Phase 2
45 Antirheumatic Agents Phase 2
46 Cyclooxygenase Inhibitors Phase 2
47 Fibrinolytic Agents Phase 2
48 Platelet Aggregation Inhibitors Phase 2
49 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole Phase 2
50
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166

Interventional clinical trials:

(show top 50) (show all 54)
id Name Status NCT ID Phase
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3
5 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
6 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2
11 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
12 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2
13 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Recruiting NCT01345136 Phase 2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2
17 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2
18 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Recruiting NCT02831257 Phase 2
19 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2
20 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
21 Study of Aspirin in Patients With Vestibular Schwannoma Not yet recruiting NCT03079999 Phase 2
22 PTC299 for Treatment of Neurofibromatosis Type 2 Suspended NCT00911248 Phase 2
23 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2
24 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
25 An Implant for Hearing Loss Due to Removal of Neurofibromatosis 2 Tumors Completed NCT00030043 Phase 1
26 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1
27 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
28 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1
29 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231
30 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
31 NF2 Natural History Consortium Unknown status NCT00004483
32 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896
33 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
34 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
35 A Family Study of Adults With Glioma Completed NCT00339352
36 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
37 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
38 Resiliency Training for Patients With Neurofibromatosis Via Videoconferencing With Skype Completed NCT02298270
39 Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study Recruiting NCT01938677
40 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325
41 Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy Recruiting NCT01129687
42 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1
43 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Recruiting NCT01880749 Early Phase 1
44 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Recruiting NCT02811718
45 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
46 Neurofibromatosis (NF) Registry Portal Recruiting NCT01885767
47 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Active, not recruiting NCT02309099
48 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
49 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678
50 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Not yet recruiting NCT02948790

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Genetic tests related to Acoustic Neuroma:

id Genetic test Affiliating Genes
1 Vestibular Schwannoma 29

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

39
Brain, Testes, Bone, Temporal Lobe, Lung, Eye, Pituitary

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 571)
id Title Authors Year
1
Acoustic neuroma as first sign of inner ear functional disorders. ( 27935543 )
2016
2
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016
3
Suspected Acoustic Neuroma Demyelinating Lesions. ( 28005807 )
2016
4
The Fully Endoscopic Acoustic Neuroma Surgery. ( 27565388 )
2016
5
SU-F-T-611: Critical Analysis and Efficacy of Linac Based (Beam Modulator) and Cyberknife Treatment Plans for Acoustic Neuroma/schwannoma. ( 28047111 )
2016
6
Acoustic Neuroma Mimicking Orofacial Pain: A Unique Case Report. ( 28053796 )
2016
7
The Persistence of Tinnitus after Acoustic Neuroma Surgery. ( 27095048 )
2016
8
In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging-based fiber tracking. ( 26722859 )
2016
9
Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis. ( 26996581 )
2016
10
Change in tinnitus after acoustic neuroma removal using a translabyrinthine approach. A Prospective study. ( 27067182 )
2016
11
Surgical treatment of acoustic neuroma: Outcomes and indications. ( 27330426 )
2016
12
Dorsal displacement of the facial nerve in acoustic neuroma surgery: clinical features and surgical outcomes of 21 consecutive dorsal pattern cases. ( 26621676 )
2016
13
Multifactor Influences of Shared Decision-Making in Acoustic Neuroma Treatment. ( 27930442 )
2016
14
SU-F-T-612: Investigation of Acoustic Neuroma Planning for Stereotactic Radiosurgery Utilizing Linac-Based Cone Collimators. ( 28046447 )
2016
15
Suspected Acoustic Neuroma Demyelinating Lesions. ( 27579562 )
2016
16
Unilateral acoustic neuromas in childhood without evidence of neurofibromatosis: experience in 10 patients at a single institute. ( 27593791 )
2015
17
Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma. ( 25813527 )
2015
18
Life-threatening posterior fossa cyst induced by pseudomeningocele after operation for acoustic neuroma. ( 25883852 )
2015
19
Fat graft-assisted internal auditory canal closure after retrosigmoid transmeatal resection of acoustic neuroma: Technique for prevention of cerebrospinal fluid leakage. ( 26482457 )
2015
20
Chronic balance disorders after acoustic neuroma surgery: assessment of gravitational vertical perception. ( 25748558 )
2015
21
Quality of life in acoustic neuroma patients. ( 25473957 )
2015
22
Impact of Elevation of Temporal Lobe During Middle Fossa Acoustic Neuroma Surgery on Contralateral Speech Discrimination. ( 26536414 )
2015
23
Acoustic neuroma manifesting as toothache and numbness. ( 25625716 )
2015
24
When is an acoustic neuroma not an acoustic neuroma? Pitfalls for radiosurgeons. ( 26041515 )
2015
25
Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study. ( 26645964 )
2015
26
Self-reported symptoms and patient experience: A British Acoustic Neuroma Association survey. ( 26523744 )
2015
27
Otologic manifestations of acoustic neuroma. ( 25578127 )
2015
28
Facial reanimation after acoustic neuroma resection: options and timing of intervention. ( 25958894 )
2015
29
Abducens nerve schwannoma in cerebellopontine angle mimicking acoustic neuroma. ( 25759926 )
2015
30
Retrosigmoid Versus Translabyrinthine Approach for Acoustic Neuroma Resection: An Assessment of Complications and Payments in a Longitudinal Administrative Database. ( 26623224 )
2015
31
Electroacupuncture therapy for abducent palsy after acoustic neuroma surgery. ( 25739636 )
2015
32
Retrosigmoid versus translabyrinthine approach to acoustic neuroma resection: A comparative cost-effectiveness analysis. ( 26490680 )
2015
33
Risk Factors for Postoperative Cerebral Vasospasm After Surgical Resection of Acoustic Neuroma. ( 26187110 )
2015
34
Tinnitus following treatment for sporadic Acoustic neuroma. ( 26403598 )
2015
35
Preoperative Lumbar Drain Use During Acoustic Neuroma Surgery and Effect on CSF Leak Incidence. ( 26239000 )
2015
36
The changing face of acoustic neuroma management in the USA: Analysis of the 1998 and 2008 patient surveys from the acoustic neuroma association. ( 23869572 )
2014
37
Facial neuroma masquerading as acoustic neuroma. ( 24775608 )
2014
38
Protection of Facial Nerves During Acoustic Neuroma Surgery. ( 25420533 )
2014
39
Magnetic Resonance Spectroscopy Features of Heschl's Gyri in Patients with Unilateral Acoustic Neuroma: Preliminary Study. ( 25172413 )
2014
40
Improved preservation of function during acoustic neuroma surgery. ( 25343177 )
2014
41
Long-term mobile phone use and acoustic neuroma. ( 25076157 )
2014
42
Acoustic neuroma: An investigation of associations between tumor size and diagnostic delays, facial weakness, and surgical complications. ( 25181660 )
2014
43
Loud noise exposure and acoustic neuroma. ( 24786799 )
2014
44
What is the best method to treat CSF leaks following resection of an acoustic neuroma? ( 25263342 )
2014
45
Retractorless translabyrinthine approach for resection of a large acoustic neuroma: operative video and technical nuances. ( 24380514 )
2014
46
Validation of self-reported start year of mobile phone use in a Swedish case-control study on radiofrequency fields and acoustic neuroma risk. ( 25352163 )
2014
47
Acoustic neuroma: potential risk factors and audiometric surveillance in the aluminium industry. ( 25015928 )
2014
48
Retrosigmoid removal of small acoustic neuroma: curative tumor removal with preservation of function. ( 24995779 )
2014
49
Long-term Mobile Phone Use and Acoustic Neuroma Risk. ( 24434752 )
2014
50
A United Kingdom Survey of Concerns, Needs, and Priorities Reported by Patients Diagnosed With Acoustic Neuroma. ( 25118579 )
2014

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 ERCC5 LIG1 MGMT MSH2 NBN PARP1
2
Show member pathways
12.49 ERCC5 LIG1 PARP1 PCNA
3 12.09 MGMT MSH2 NBN PCNA
4
Show member pathways
11.77 ERCC5 LIG1 MGMT MSH2 NBN PARP1
5 11.69 ERCC5 MGMT MSH2 PCNA
6 11.66 AQP1 AQP4 TGFB1
7
Show member pathways
11.54 LIG1 MSH2 PCNA
8
Show member pathways
11.52 ERCC5 LIG1 PARP1 PCNA
9 10.9 NBN PCNA

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.86 ERCC5 LIG1 MGMT MSH2 NBN PARP1
2 nucleus GO:0005634 9.7 AQP1 ERCC5 LIG1 MGMT MSH2 NBN
3 replication fork GO:0005657 9.16 NBN PCNA
4 nuclear chromosome, telomeric region GO:0000784 8.92 MSH2 NBN PARP1 PCNA

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 ABCA2 AQP1 MGMT TGFB1
2 DNA replication GO:0006260 9.81 LIG1 NBN PCNA
3 cell cycle arrest GO:0007050 9.79 MSH2 NBN TGFB1
4 DNA damage response, detection of DNA damage GO:0042769 9.67 PARP1 PCNA
5 cellular response to dexamethasone stimulus GO:0071549 9.67 AQP1 TGFB1
6 liver regeneration GO:0097421 9.66 PCNA TGFB1
7 renal water homeostasis GO:0003091 9.66 AQP1 AQP4
8 cellular response to ionizing radiation GO:0071479 9.65 MGMT TGFB1
9 mitotic cell cycle checkpoint GO:0007093 9.65 NBN TGFB1
10 positive regulation of DNA repair GO:0045739 9.65 MGMT PCNA
11 transcription-coupled nucleotide-excision repair GO:0006283 9.65 ERCC5 LIG1 PCNA
12 nucleotide-excision repair, preincision complex assembly GO:0006294 9.64 ERCC5 PARP1
13 nucleotide-excision repair, DNA gap filling GO:0006297 9.63 LIG1 PCNA
14 cell-cell junction organization GO:0045216 9.63 NF2 TGFB1
15 double-strand break repair GO:0006302 9.63 MSH2 NBN PARP1
16 nucleotide-excision repair, DNA incision, 3-to lesion GO:0006295 9.62 ERCC5 PARP1
17 positive regulation of protein localization to nucleus GO:1900182 9.62 PARP1 TGFB1
18 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.61 ERCC5 PARP1
19 negative regulation of DNA replication GO:0008156 9.6 NF2 TGFB1
20 water transport GO:0006833 9.59 AQP1 AQP4
21 isotype switching GO:0045190 9.58 MSH2 NBN
22 positive regulation of transcription regulatory region DNA binding GO:2000679 9.58 PARP1 TGFB1
23 telomere maintenance GO:0000723 9.58 NBN PARP1 PCNA
24 negative regulation of cell-cell adhesion GO:0022408 9.57 NF2 TGFB1
25 lens fiber cell differentiation GO:0070306 9.56 NF2 TGFB1
26 negative regulation of telomere maintenance via telomere lengthening GO:1904357 9.54 NBN PARP1
27 nucleotide-excision repair, DNA incision GO:0033683 9.54 ERCC5 PARP1 PCNA
28 positive regulation of SMAD protein import into nucleus GO:0060391 9.52 PARP1 TGFB1
29 DNA ligation involved in DNA repair GO:0051103 9.51 LIG1 PARP1
30 nucleotide-excision repair, DNA incision, 5-to lesion GO:0006296 9.5 ERCC5 PARP1 PCNA
31 cellular response to DNA damage stimulus GO:0006974 9.5 ERCC5 LIG1 MGMT MSH2 NBN PARP1
32 multicellular organismal water homeostasis GO:0050891 9.49 AQP1 AQP4
33 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MSH2 TGFB1
34 mismatch repair GO:0006298 9.43 LIG1 MSH2 PCNA
35 DNA ligation GO:0006266 9.33 LIG1 MGMT PCNA
36 DNA repair GO:0006281 9.17 ERCC5 LIG1 MGMT MSH2 NBN PARP1

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 MSH2 PARP1 PCNA TGFB1
2 transporter activity GO:0005215 9.65 ABCA2 AQP1 AQP4
3 water channel activity GO:0015250 9.4 AQP1 AQP4
4 MutLalpha complex binding GO:0032405 9.37 MSH2 PCNA
5 damaged DNA binding GO:0003684 9.33 MSH2 NBN PCNA
6 water transmembrane transporter activity GO:0005372 9.32 AQP1 AQP4
7 DNA ligase (ATP) activity GO:0003910 9.26 LIG1 PARP1
8 dinucleotide insertion or deletion binding GO:0032139 8.96 MSH2 PCNA
9 protein N-terminus binding GO:0047485 8.92 ERCC5 NBN PARP1 TGFB1
10 DNA binding GO:0003677 10 ERCC5 LIG1 MGMT MSH2 PARP1 PCNA

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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