MCID: ACS001
MIFTS: 54

Acoustic Neuroma malady

Neuronal, Cancer categories

Summaries for Acoustic Neuroma

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. the tumor usually grows slowly. as it grows, it presses against the hearing and balance nerves. at first, you may have no symptoms or mild symptoms. they can include loss of hearing on one side ringing in ears dizziness and balance problems the tumor can also eventually cause numbness or paralysis of the face. if it grows large enough, it can press against the brain, becoming life-threatening. acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. ear exams, hearing tests, and scans can show if you have it. if the tumor stays small, you may only need to have it checked regularly. if you do need treatment, surgery and radiation are options. if the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. nih: national institute of deafness and communication disorders

MalaCards: Acoustic Neuroma, also known as vestibular schwannoma, is related to adenocarcinoma and adenoma. An important gene associated with Acoustic Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Cytosolic Iron-sulfur Cluster Assembly. The compounds l189 and phosphodiester have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and b cells, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:64 A vestibular schwannoma, often called an acoustic neuroma, is a benign primary intracranial tumor of the... more...

Aliases & Classifications for Acoustic Neuroma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 45Novoseek, 35MeSH, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

acoustic neuroma 8 43 10 49 34 61
vestibular schwannoma 8 49
acoustic neurilemoma 43 49
acoustic neurinoma 43 49
neurinoma of the acoustic nerve 43
cerebellopontine angle tumor 43
vestibular neurilemmoma 8
neuroma acoustic 45
acoustic tumor 43


External Ids:

Disease Ontology8 DOID:12689
MeSH35 D009464
NCIt40 C3276

Related Diseases for Acoustic Neuroma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to acoustic neuroma

Clinical Features for Acoustic Neuroma

Drugs & Therapeutics for Acoustic Neuroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Acoustic Neuroma

Drug clinical trials:

Search ClinicalTrials for Acoustic Neuroma

Search NIH Clinical Center for Acoustic Neuroma

Search CenterWatch for Acoustic Neuroma

Genetic Tests for Acoustic Neuroma

Anatomical Context for Acoustic Neuroma

Sources:
33MalaCards
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MalaCards organs/tissues related to Acoustic Neuroma:

33
Brain, Lung, B cells, Temporal lobe, Occipital lobe, Pituitary

Animal Models for Acoustic Neuroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Acoustic Neuroma

Sources:
51PubMed
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Articles related to Acoustic Neuroma:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Intractable headache after excision of an acoustic neuroma treated by stent revascularisation of the sigmoid sinus. (23647052)
2013
2
Interaural Difference of Wave V Predicting Postoperative Hearing in Gardner-Robertson Class II Acoustic Neuroma Patients. (24436924)
2013
3
Acoustic neuroma neurophysiologic correlates: vestibular-preoperative, intraoperative, and postoperative. (22483818)
2012
4
The impact of comorbidities, regional trends, and hospital factors on discharge dispositions and hospital costs after acoustic neuroma microsurgery: a United States nationwide inpatient data sample study (2005-2009). (22937854)
2012
5
Intraoperative continuous monitoring of evoked facial nerve electromyograms in acoustic neuroma surgery. (21340712)
2011
6
Long-term follow-up confirms the efficacy of linac radiosurgery for acoustic neuroma and meningioma patients. A single institution's experience. (20414930)
2010
7
Prevalence of acoustic neuroma associated with each configuration of pure tone audiogram in patients with asymmetric sensorineural hearing loss. (21033029)
2010
8
The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. (19358774)
2009
9
Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. (19128648)
2008
10
Environmental risk factors for sporadic acoustic neuroma (Interphone Study Group, Germany). (17600696)
2007
11
Ruptured intracranial aneurysm following gamma knife surgery for acoustic neuroma. (17043748)
2006
12
Re: "Exposure to loud noise and risk of acoustic neuroma". (16943265)
2006
13
Unilateral deafness after acoustic neuroma surgery: subjective hearing handicap and the effect of the bone-anchored hearing aid. (16885786)
2006
14
Mobile phone use and acoustic neuroma risk in Japan. (16912083)
2006
15
An unusual site of a CSF leak following resection of a retrosigmoid acoustic neuroma. (16615598)
2006
16
Distortion of magnetic resonance images used in gamma knife radiosurgery treatment planning: implications for acoustic neuroma outcomes. (16272946)
2005
17
Case report: optic disc edema without hydrocephalus in acoustic neuroma. (16148986)
2005
18
Perioperative complications in acoustic neuroma (vestibular schwannoma) surgery. (15129121)
2004
19
Acoustic neuroma ingrowth in the cochlear nerve: does it influence the clinical presentation? (15274421)
2004
20
Translabyrinthine approach for acoustic neuroma. (14744286)
2004
21
Histopathology of the inner ear in unoperated acoustic neuroma. (14653368)
2003
22
Surgical excision of acoustic neuroma: patient outcome and provider caseload. (12897555)
2003
23
Re: Factors affecting recovery after acoustic neuroma resection by Cohen et al. (14575408)
2003
24
Acoustic neuroma: outcome study. (12240754)
2002
25
Osteoplastic lateral suboccipital approach for acoustic neuroma surgery. (11152354)
2001
26
Audiovestibular findings and location of an acoustic neuroma. (10923934)
2000
27
My experience with acoustic neuroma. (11188573)
2000
28
Immediate neurological deterioration after gamma knife radiosurgery for acoustic neuroma. Case report. (11143268)
2000
29
There is a role for ABR audiometry in the diagnosis of acoustic neuroma. (10037294)
1999
30
Cost-effective screening for acoustic neuroma. (10580257)
1999
31
Haemorrhagic acoustic neuroma with features of a vascular malformation. A case report. (10552033)
1999
32
Disability from vestibular symptoms after acoustic neuroma resection. (9455958)
1998
33
Intra-operative monitoring in acoustic neuroma surgery. (9785586)
1998
34
Pneumocephalus after acoustic neuroma surgery. (9831162)
1998
35
Quality of life following acoustic neuroma surgery. (17112220)
1998
36
Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention. (9202266)
1997
37
Electrically evoked auditory brainstem response by direct electrical stimulation to the cochlear nerve in acoustic neuroma patients. (9166874)
1997
38
Preoperative electroneuronography and facial nerve outcome in acoustic neuroma surgery. (9149839)
1997
39
Hearing preservation after acoustic neuroma resection with tumor size used as a clinical prognosticator. (9261019)
1997
40
Tinnitus and translabyrinthine acoustic neuroma surgery. (9390844)
1997
41
The evolving MR appearance of structures in the internal auditory canal after removal of an acoustic neuroma. (9111669)
1997
42
The widened retrolabyrinthe approach: a new concept in acoustic neuroma surgery. (9126897)
1997
43
Surgical treatment of acoustic neuroma (vestibular schwannoma) in the United States: report from the Acoustic Neuroma Registry. (8544629)
1996
44
Residual and recurrent acoustic neuroma in hearing preservation procedures: neuroradiologic and surgical findings. (17170984)
1996
45
Normal hearing in acoustic neuroma patients: a critical evaluation. (8694116)
1996
46
Cerebrospinal fluid drainage in the management of CSF leak following acoustic neuroma surgery. (8699889)
1996
47
Cochlear implantation in a patient after removal of an acoustic neuroma. (8630217)
1996
48
Radiosurgery: a minimally interventional alternative to microsurgery in the management of acoustic neuroma. (8861308)
1996
49
Early audiological findings of NF2 with an acoustic neuroma. (8689710)
1995
50
Comparative study on gait abnormality in patients with vestibular neuronitis and patients with large acoustic neuroma. (7610866)
1995

Genetic Variations for Acoustic Neuroma

Expression for genes affiliated with Acoustic Neuroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for genes affiliated with Acoustic Neuroma

Sources:
54Reactome, 50PharmGKB, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
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Pathways related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3RAD23B, XPC
210.3ERCC2, RTEL1
3
Hide members
10.3MUTYH, POLB
410.2ERCC2, XRCC3
5
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10.2RAD52, RAD51
6
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10.2LIG1, POLB, MUTYH
7
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.1RAD51, POLB, XPC
8
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10.1ERCC4, ERCC5, ERCC2
9
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10.0RAD52, RAD51, XRCC2, XRCC3
10
Hide members
10.0LIG4, LIG1, RAD51, RAD52
11
Hide members
9.9XPC, MUTYH, RAD51, RAD52, ERCC2
12
Hide members
9.7XPC, LIG4, LIG1, RAD23B, ERCC4, ERCC5
13
Hide members
9.5XPC, LIG4, LIG1, POLB, RAD23B, RAD51
14
Hide members
9.2ERCC2, XPC, LIG4, LIG1, POLB, MUTYH

Compounds for genes affiliated with Acoustic Neuroma

Sources:
60Tocris Bioscience, 45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 11DrugBank
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Compounds related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1l1896010.5LIG1, LIG4
2phosphodiester4510.5ERCC5, POLB, LIG1
38-oxo-dg4510.5LIG1, POLB, MUTYH
48-oxo-dgtp45 2411.4MUTYH, POLB
5aphidicolin4510.4RAD51, POLB, LIG1
6sugar phosphate4510.4RAD51, POLB
7polynucleotide4510.4RAD51, POLB, LIG1, LIG4
8thymine45 2411.4RAD51, POLB, XPC
9thymine glycol4510.4POLB, ERCC5
10methylmethanesulfonate4510.3POLB, RAD51, RAD52
11caffeine45 50 29 2 11 2415.3RAD51, LIG1, XRCC2, XRCC3
12camptothecin45 60 1112.3XRCC3, XRCC2, RAD51, RAD52
13ecteinascidin 7434510.3ERCC2, ERCC5
14thymidylate4510.3POLB, RAD51, ERCC4, ERCC2
15mitomycin c4510.3XRCC3, XRCC2, POLB, RAD51, ERCC4
16melphalan45 1111.2XRCC3, POLB, RAD51, ERCC4, ERCC2
17adenine45 11 2412.1RAD51, MUTYH, POLB
188-oxoguanine4510.0MUTYH, POLB
19oligonucleotide459.8XPC, LIG1, POLB, RAD51, ERCC5
20atp45 2910.8XPC, LIG1, POLB, FKBP4, RAD51, ERCC5
21cisplatin45 50 60 1112.7ERCC2, XRCC3, XRCC2, XPC, LIG1, POLB

GO Terms for genes affiliated with Acoustic Neuroma

Sources:
16Gene Ontology
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Cellular components related to Acoustic Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.3RAD23B, XPC
2condensed chromosomeGO:00079310.3RAD51, LIG4
3holo TFIIH complexGO:0056759.9ERCC2, ERCC5
4nucleoplasmGO:0056549.3ERCC2, XPC, LIG4, LIG1, POLB, MUTYH
5cytoplasmGO:0057379.1LIG4, CRLF1, XPC, XRCC3, SSTR1, NF2
6nucleusGO:0056348.7POLB, NF2, LIG1, LIG4, XPC, XRCC2

Biological processes related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.6XPC, RAD23B
2nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.5ERCC4, ERCC5
3lagging strand elongationGO:00627310.5LIG4, LIG1
4regulation of mitotic cell cycle phase transitionGO:190199010.5XPC, ERCC2
5nucleotide-excision repair, DNA gap fillingGO:00629710.5POLB, LIG1, LIG4
6nucleotide-excision repair, DNA incisionGO:03368310.5ERCC4, ERCC2
7DNA recombinase assemblyGO:00073010.4RAD52, RAD51
8base-excision repairGO:00628410.4MUTYH, POLB, LIG1
9UV protectionGO:00965010.4ERCC2, ERCC5, ERCC4
10DNA ligation involved in DNA repairGO:05110310.4LIG1, LIG4
11mitotic recombinationGO:00631210.4RAD52, RAD51
12V(D)J recombinationGO:03315110.4LIG4, LIG1
13telomere maintenanceGO:00072310.4LIG1, RTEL1, ERCC4
14double-strand break repairGO:00630210.4LIG4, LIG1, RAD51, RAD52
15transcription-coupled nucleotide-excision repairGO:00628310.3LIG1, ERCC4, ERCC5, ERCC2
16regulation of double-strand break repair via homologous recombinationGO:01056910.3RTEL1, RAD51
17positive regulation of neurogenesisGO:05076910.3LIG4, XRCC2
18double-strand break repair via homologous recombinationGO:00072410.3XRCC2, LIG1, RAD51, RAD52, ERCC4
19nucleotide-excision repair, DNA damage removalGO:00071810.3XPC, RAD23B, ERCC4, ERCC5, ERCC2
20negative regulation of neuron apoptotic processGO:04352410.2XRCC2, CRLF1, LIG4
21double-strand break repair via nonhomologous end joiningGO:00630310.2LIG1, LIG4
22nucleotide-excision repairGO:00628910.1XPC, LIG1, RAD23B, ERCC4, ERCC5, ERCC2
23response to X-rayGO:01016510.0LIG4, XRCC2
24DNA repairGO:0062819.3ERCC2, XRCC3, XRCC2, XPC, LIG4, LIG1

Molecular functions related to Acoustic Neuroma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
2DNA ligase activityGO:00390910.5LIG4, LIG1
3DNA-dependent ATPase activityGO:00809410.4ERCC2, XRCC2, XRCC3
44 iron, 4 sulfur cluster bindingGO:05153910.3ERCC2, RTEL1, MUTYH
5bubble DNA bindingGO:00040510.3XPC, ERCC5
6damaged DNA bindingGO:00368410.2ERCC4, RAD51, RAD23B, POLB, XPC
7single-stranded DNA bindingGO:00369710.2XPC, RAD23B, RAD51, ERCC4, ERCC5
8protein C-terminus bindingGO:00802210.1LIG4, RAD51, ERCC4, ERCC2
9protein N-terminus bindingGO:04748510.1ERCC2, ERCC5, ERCC4
10endodeoxyribonuclease activityGO:0045209.9ERCC5, ERCC4
11ATP bindingGO:0055249.8XRCC3, XRCC2, LIG4, LIG1, FKBP4, RAD51
12DNA bindingGO:0036779.7XRCC3, XRCC2, LIG4, LIG1, RAD52, RTEL1
13metal ion bindingGO:0468729.5LIG4, LIG1, POLB, MUTYH, RTEL1, ZNF350
14protein bindingGO:0055158.9POLB, NF2, LIG4, CRLF1, XPC, XRCC2

Products for genes affiliated with Acoustic Neuroma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Acoustic Neuroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet