MCID: ACQ012
MIFTS: 35

Acquired Angioedema malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Skin diseases

Aliases & Classifications for Acquired Angioedema

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Aliases & Descriptions for Acquired Angioedema:

Name: Acquired Angioedema 46 66
Acquired C1 Inhibitor Deficiency 46
 
Angioedema, Acquired 46

Classifications:



Summaries for Acquired Angioedema

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NIH Rare Diseases:46 Acquired angioedema (aae) is a rare condition characterized by recurrent episodes of swelling (edema). affected people may have swelling of the face, lips, tongue, limbs, and genitals. sometimes there is abdominal pain due to edema of the gastrointestinal mucosa, and life-threatening edema of the upper respiratory tract. swelling episodes may be triggered by mild trauma (e.g., dental work), viral illness, cold exposure, pregnancy, ingestion of certain foods, or emotional stress. there are two forms of aae: type i and type ii. aae type i is most commonly associated with b-cell lymphoproliferative disorders and consumption of c1-inh.  aae type ii is an autoimmune condition associated with the presence of an autoantibody against c1-inh. treatment aims to control episodes and normalize c1-inh levels. when possible, the underlying disorder should be treated. last updated: 8/25/2014

MalaCards based summary: Acquired Angioedema, also known as acquired c1 inhibitor deficiency, is related to acquired angioedema type 2 and acquired angioedema type 1. An important gene associated with Acquired Angioedema is SERPING1 (Serpin Family G Member 1), and among its related pathways are Staphylococcus aureus infection and Pertussis. Affiliated tissues include b cells, tongue and testes, and related mouse phenotype cardiovascular system.

Related Diseases for Acquired Angioedema

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Diseases in the Angioedema family:

Angioedema, Hereditary, Type Iii Angioedema, Hereditary, Types I and Ii
Hereditary Angioedema acquired angioedema
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Acquired Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1acquired angioedema type 212.2
2acquired angioedema type 112.1
3angioedema induced by ace inhibitors11.1
4angioedema10.6
5autoimmune disease of endocrine system10.4C1S, SERPING1
6methylmalonic acidemia10.3C1S, SERPING1
7dermatomycosis10.3C1S, SERPING1
8autosomal dominant cerebellar ataxia10.2C3, SERPING1
9inflammatory breast carcinoma10.2C3, SERPING1
10meesmann corneal dystrophy10.2C1S, C3
11exophthalmic ophthalmoplegia10.1F5, HP
12c1 inhibitor deficiency10.1
13lymphoma10.1
14pemphigus foliaceus10.0C3, HP
15methotrexate-associated lymphoproliferation10.0C3, HP
16hereditary angioedema10.0
17mechanical lagophthalmos9.9CRP, SERPING1
18hepatoid pattern testicular yolk sac tumor9.9CRP, F5
19hyperthyroxinemia9.9CRP, HP
20homocystinuria due to defect in methylation cbl g9.9CRP, F5
21hepatocellular adenoma9.9CRP, F5
22chronic lymphocytic leukemia9.9
23leukemia9.9
24lingual-facial-buccal dyskinesia9.9CRP, F5
25balantidiasis9.8CRP, HP
26breast adenomyoepithelioma9.8CRP, HP
27post-traumatic stress disorder9.8C3, CRP
28acquired thrombocytopenia9.8C3, CRP
29polyarteritis nodosa9.8C3, CRP
30chromoblastomycosis9.8C3, CRP
31granuloma annulare9.8C1S, C3
32jumping frenchmen of maine9.8CRP, F5
33pneumocystosis9.8C3, CRP
34ulcerative blepharitis9.8CRP, F5
35vestibular nystagmus9.7CRP, HP
36borderline glaucoma9.7CRP, F5
37psoriatic arthritis9.7
38anaplastic large cell lymphoma9.7
39arthritis9.7
40b-cell lymphomas9.7
41hemolytic anemia9.7
42hepatitis9.7
43marginal zone b-cell lymphoma9.7
44myelofibrosis9.7
45sinusitis9.7
46splenic marginal zone lymphoma9.7
47hepatitis c9.7
48antiphospholipid syndrome9.7
49adenocarcinoma9.7
50autoimmune hemolytic anemia9.7

Graphical network of the top 20 diseases related to Acquired Angioedema:



Diseases related to acquired angioedema

Symptoms for Acquired Angioedema

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Drugs & Therapeutics for Acquired Angioedema

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Drugs for Acquired Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoratadinePhase 49079794-75-53957
Synonyms:
1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester
4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
79794-75-5
AC-2086
AC1L1H3E
Aerotina
Alarin
Alavert
Alavert, Claritin, Loratadine
Alerpriv
Allertidin
Amantadine
Anhissen
BB_SC-2109
BIDD:GT0198
BRD-K82795137-001-02-3
BRD-K82795137-001-10-6
BSPBio_002300
Bedix Loratadina
Biloina
Bonalerg
C22H23ClN2O2
CHEMBL998
CID3957
CPD000058255
Children's Claritin
Civeran
Claratyne
Claratyne Cold
Claratyne Decongestant
Clarinase
Clarinase Reperabs
Claritin
Claritin (TN)
Claritin D
Claritin Hives Relief
Claritin Hives Relief Reditab
Claritin Reditabs
Claritin reditab
Claritine
Clarityn
Clarityne
Clarityne Dy Repetabs
Clarityne-D
Clarium
Cronopen
D00364
D017336
DB00455
DivK1c_000792
EU-0100680
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate
Flonidan
Fristamin
HMS2051G11
HMS2090O18
HMS2093I15
HMS502H14
HSDB 3578
Histaloran
I14-0747
IDI1_000792
KBio1_000792
KBio2_001976
KBio2_004544
KBio2_007112
KBio3_001520
KBioGR_000693
KBioSS_001976
Klaritin
L 9664
L000667
L0223
L9664_SIGMA
LS-114660
 
Lergy
Lertamine
Lesidas
Lisino
Lopac-L-9664
Lopac0_000680
Loracert
Loradex
Loradif
Loranox
Lorantis
Lorastine
Loratadina
Loratadina [Spanish]
Loratadine
Loratadine (JAN/USAN/INN)
Loratadine Redidose
Loratadine Wyeth Brand
Loratadine [USAN:BAN:INN]
Loratadinum
Loratadinum [Latin]
Loratidine
Loratyne
Loraver
Lorfast
Loritine
Lowadina
MLS000069647
MLS000758260
MLS001148466
MolPort-002-507-846
NCGC00015619-01
NCGC00015619-02
NCGC00015619-06
NCGC00015619-10
NCGC00023125-02
NCGC00023125-04
NCGC00023125-05
NCGC00023125-06
NCGC00023125-07
NCI60_041473
NINDS_000792
NSC721075
Nularef
Oprea1_027965
Optimin
Polaratyne
Pylor
Restamine
Rhinase
Rinomex
Roletra
S1358_Selleck
SAM001246987
SMR000058255
SPBio_001548
SPECTRUM1503712
STK574925
Sanelor
Sch 29851
Sch-29851
Sch29851
Sensibit
Sinhistan Dy
Sohotin
Spectrum2_001584
Spectrum3_000740
Spectrum4_000177
Spectrum5_001650
Spectrum_001496
TL8005389
Tadine
Talorat Dy
Tocris-1944
UNII-7AJO3BO7QN
Velodan
Versal
Wyeth Brand of Loratadine
ZINC00537931
Zeos
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
loratadine
2
DesloratadinePhase 470100643-71-8124087
Synonyms:
100643-71-8
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-chloro-6,11-dihydro-11-(4-Piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
AC-1279
AC1L3XUD
AKOS000280921
Aerius
Allex
Azomyr
BB_SC-2104
C121345
CHEBI:291342
CHEMBL1172
CID124087
CPD000149358
Claramax
Clarinex
Clarinex (TN)
Clarinex RediTabs
Clarinex Reditabs
D03693
D3787
DB00967
DESLORATADINE
Denosin
Desalex
Descarboethoxyloratadine
Descarboethoxyoratidine
 
Desloratadine
Desloratadine (USAN/INN)
Desloratadine [USAN]
Desloratidine
Essex brand of desloratadine
HMS2052H05
HMS2090C06
HMS2093F19
I06-1866
L001025
LS-181814
MLS000559042
MLS000759406
MLS001201801
MolPort-000-883-875
NCGC00159325-02
NCGC00159325-03
NCGC00159325-04
NSC675447
NeoClarityn
Neoclarityn
Opulis
SAM001246545
SMR000149358
STK586537
Sch 34117
Sch-34117
Schering brand of desloratadine
Schering-Plough brand of desloratadine
TL8000065
UNII-FVF865388R
desloratadine
3
Histamine PhosphatePhase 4100851-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
4
histaminePhase 4100975614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
5
Bradykinin4958-82-2439201
Synonyms:
Callidin I
Kallidin 9
 
Kallidin I
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
L-Bradykinin

Interventional clinical trials:

idNameStatusNCT IDPhase
1Desloratadine 5, 10 and 20mg in Patients With Cold UrticariaCompletedNCT01444196Phase 4
2C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125541Phase 2, Phase 3
3C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125151Phase 3
4Kinetics, Efficacy and Safety of C1-Esteraseremmer-NCompletedNCT00119431Phase 2
5Determination of Specific Biomarkers of Angioneurotic CrisisRecruitingNCT02833675

Search NIH Clinical Center for Acquired Angioedema

Genetic Tests for Acquired Angioedema

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Anatomical Context for Acquired Angioedema

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MalaCards organs/tissues related to Acquired Angioedema:

34
B cells, Tongue, Testes, Skin, Colon

Animal Models for Acquired Angioedema or affiliated genes

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MGI Mouse Phenotypes related to Acquired Angioedema:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.6C3, CRP, F5, HP, SERPING1

Publications for Acquired Angioedema

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Articles related to Acquired Angioedema:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Shortened Activated Partial Thromboplastin Time May Help in Diagnosing Hereditary and Acquired Angioedema. (27463190)
2016
2
A case of acquired angioedema possibly associated with adenocarcinoma of the colon. (27026513)
2016
3
Non-myeloablative allogeneic stem cell transplantation: a new treatment option for acquired angioedema? (26478549)
2015
4
The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity. (26068904)
2015
5
A UK national audit of hereditary and acquired angioedema. (23786259)
2014
6
Acquired angioedema with C1 inhibitor deficiency secondary to splenic marginal zone B-cell lymphoma. (24970460)
2014
7
Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema. (25506230)
2014
8
An evidence based therapeutic approach to hereditary and acquired angioedema. (24983294)
2014
9
A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema. (24352125)
2013
10
Chapter 22: Hereditary and acquired angioedema. (22794695)
2012
11
Acquired angioedema and marginal zone lymphoma. (22508826)
2012
12
Rapid resolution of erythema marginatum after icatibant in acquired angioedema. (21279303)
2011
13
Treatment of acquired angioedema with icatibant: a case report. (20680518)
2011
14
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
15
"Surgical" abdomen in a patient with chronic lymphocytic leukemia: a case of acquired angioedema. (21997434)
2011
16
Acquired angioedema with C1 inhibitor deficiency associated with anticardiolipin antibodies. (22230421)
2011
17
Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. (20929611)
2010
18
Successful use of etanercept in acquired angioedema in a patient with psoriatic arthritis. (20040647)
2010
19
Optimal medical management of acute attacks of acquired angioedema. (20042567)
2010
20
Acquired angioedema. (20667117)
2010
21
Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. (18204284)
2008
22
Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. (18447143)
2008
23
Acute upper airway obstruction from acquired angioedema. (17305664)
2007
24
Acquired angioedema in non-Hodgkin's lymphoma. (17317233)
2007
25
Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency. (16887400)
2006
26
Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation. (16472576)
2006
27
Acquired angioedema secondary to hormone replacement therapy. (16272680)
2005
28
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. (15356535)
2004
29
Hereditary and acquired angioedema: experience with patients in Puerto Rico. (15125214)
2004
30
Acquired angioedema: a new target for rituximab? (15339702)
2004
31
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
32
Profhylaxis and treatment of hereditary and acquired angioedema at HUB; use of the C1-esterase inhibitor]. (14974880)
2003
33
Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2. (12208377)
2002
34
Anaplastic large cell lymphoma and acquired angioedema: a novel association? (12402660)
2002
35
Protein sgp 120 as a marker of an acquired angioedema. (11029608)
2000
36
Does acquired angioedema increase the risk of surgery with cardiopulmonary bypass? (10962426)
2000
37
Hereditary or acquired angioedema caused by functional deficiency of C1 inhibitor--a still unfamiliar disease picture]. (10093876)
1999
38
Acquired angioedema with C1 inhibitor deficiency: is the distinction between type I and type II still relevant? (10592402)
1999
39
Acquired angioedema associated with chronic hepatitis C. (10200025)
1999
40
Acquired angioedema. (9092748)
1997
41
Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid. (8182230)
1994
42
Ascher syndrome: a mimicker of acquired angioedema. (8408805)
1993
43
Immunoadsorption in acquired angioedema: a therapeutic misadventure. (8453789)
1993
44
C1 inhibitor deficiency: molecular and immunologic basis of hereditary and acquired angioedema. (1921329)
1991
45
Acquired angioedema and anti-C1-inhibitor autoantibody. (2719515)
1989
46
Acquired angioedema: observations on the mechanism of action of autoantibodies directed against C1 esterase inhibitor. (2454251)
1988
47
Acquired angioedema. (3203091)
1988
48
Acquired angioedema and hypocompleentemia in a patient with myelofibrosis. Effect of danazol treatment. (6899952)
1980
49
Acquired angioedema associated with rectal carcinoma and its response to danazol therapy. Acquired angioedema treated with danazol. (701655)
1978
50
Acquired angioedema with lymphoproliferative disorder: association of C1 inhibitor deficiency with cellular abnormality. (1085645)
1976

Variations for Acquired Angioedema

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Expression for genes affiliated with Acquired Angioedema

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Search GEO for disease gene expression data for Acquired Angioedema.

Pathways for genes affiliated with Acquired Angioedema

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GO Terms for genes affiliated with Acquired Angioedema

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Cellular components related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.2F5, SERPING1
2blood microparticleGO:00725628.7C1S, C3, HP, SERPING1
3extracellular exosomeGO:00700627.6C1S, C3, CRP, HP, SERPING1
4extracellular spaceGO:00056157.3C3, CRP, F5, HP, SERPING1
5extracellular regionGO:00055767.0C1S, C3, CRP, F5, HP, SERPING1

Biological processes related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement activationGO:00069569.8C1S, C3
2negative regulation of endopeptidase activityGO:00109519.6C3, SERPING1
3blood circulationGO:00080159.5F5, SERPING1
4platelet degranulationGO:00025769.4F5, SERPING1
5complement activation, classical pathwayGO:00069589.3C1S, C3, SERPING1
6acute-phase responseGO:00069539.2CRP, HP

Molecular functions related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042528.9C1S, C3, F5

Sources for Acquired Angioedema

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet