MCID: ACQ012
MIFTS: 39

Acquired Angioedema malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Skin diseases

Aliases & Classifications for Acquired Angioedema

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Aliases & Descriptions for Acquired Angioedema:

Name: Acquired Angioedema 48 68
Acquired C1 Inhibitor Deficiency 48
 
Angioedema, Acquired 48

Classifications:



Summaries for Acquired Angioedema

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NIH Rare Diseases:48 Acquired angioedema (aae) is a rare condition characterized by recurrent episodes of swelling (edema). affected people may have swelling of the face, lips, tongue, limbs, and genitals. sometimes there is abdominal pain due to edema of the gastrointestinal mucosa, and life-threatening edema of the upper respiratory tract. swelling episodes may be triggered by mild trauma (e.g., dental work), viral illness, cold exposure, pregnancy, ingestion of certain foods, or emotional stress. there are two forms of aae: type i and type ii. aae type i is most commonly associated with b-cell lymphoproliferative disorders and consumption of c1-inh.  aae type ii is an autoimmune condition associated with the presence of an autoantibody against c1-inh. treatment aims to control episodes and normalize c1-inh levels. when possible, the underlying disorder should be treated. last updated: 8/25/2014

MalaCards based summary: Acquired Angioedema, also known as acquired c1 inhibitor deficiency, is related to angioedema and acquired angioedema type 2, and has symptoms including facial edema, urticaria and ascites. An important gene associated with Acquired Angioedema is SERPING1 (Serpin Family G Member 1), and among its related pathways are Staphylococcus aureus infection and Complement Pathway. Affiliated tissues include b cells, tongue and testes, and related mouse phenotype cardiovascular system.

Related Diseases for Acquired Angioedema

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Diseases in the Angioedema family:

Angioedema, Hereditary, Type Iii Angioedema, Hereditary, Types I and Ii
Hereditary Angioedema acquired angioedema
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Acquired Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1angioedema30.9C1S, SERPING1
2acquired angioedema type 212.1
3acquired angioedema type 112.0
4angioedema induced by ace inhibitors11.1
5leukocyte adhesion deficiency, type iii10.2C1S, SERPING1
6artemis deficiency10.2C1S, SERPING1
7charcot-marie-tooth disease 2a2b10.1C1S, SERPING1
8lymphangioma10.1C1S, SERPING1
9cicatricial lagophthalmos10.1CRP, SERPING1
10mechanical ectropion10.1C1S, SERPING1
11parapharyngeal meningioma10.1CRP, F5
12meesmann corneal dystrophy10.1C1S, C3
13houlston ironton temple syndrome10.1CRP, F5
14intestinal disaccharidase deficiency10.1CRP, F5
15villous adenoma10.1CRP, F5
16chronic mucocutaneous candidiasis10.1C3, CRP
17cyclotropia10.1C3, CRP
18dermatomycosis10.0C3, CRP
19arcus senilis10.0C3, CRP
20leukocyte disease10.0CRP, F5
21aids dementia complex10.0C3, F5
22hemoglobin c disease10.0CRP, HP
23c1 inhibitor deficiency10.0
24lymphoma10.0
25lung combined large cell neuroendocrine carcinoma10.0HP, SERPING1
26cervix small cell carcinoma10.0CRP, F5
27spastic entropion9.9CRP, HP
28malignant acth producing neoplasm of pituitary gland9.9C1S, C3, SERPING1
29female breast upper-inner quadrant cancer9.9CRP, HP
30uterine ligament clear cell adenocarcinoma9.9CRP, F5
31hereditary angioedema9.9
32camptodactyly-arthropathy-coxa vara-pericarditis syndrome9.9C3, CRP, SERPING1
33endometrioid ovary carcinoma9.9C3, HP
34pemphigus vulgaris9.9C3, HP
35chronic lymphocytic leukemia9.7
36leukemia9.7
37cousin syndrome9.7C1S, C3, CRP
38acute proliferative glomerulonephritis9.7F5, HP
39psoriatic arthritis9.6
40anaplastic large cell lymphoma9.6
41arthritis9.6
42b-cell lymphomas9.6
43hemolytic anemia9.6
44hepatitis9.6
45marginal zone b-cell lymphoma9.6
46myelofibrosis9.6
47sinusitis9.6
48splenic marginal zone lymphoma9.6
49thrombosis9.6
50hepatitis c9.6

Graphical network of the top 20 diseases related to Acquired Angioedema:



Diseases related to acquired angioedema

Symptoms & Phenotypes for Acquired Angioedema

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Human phenotypes related to Acquired Angioedema:

 64 (show all 8)
id Description HPO Frequency HPO Source Accession
1 facial edema64 HP:0000282
2 urticaria64 HP:0001025
3 ascites64 HP:0001541
4 abdominal pain64 HP:0002027
5 intestinal obstruction64 HP:0005214
6 intestinal edema64 HP:0005225
7 laryngeal edema64 HP:0012027
8 angioedema64 HP:0100665

MGI Mouse Phenotypes related to Acquired Angioedema according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.6C3, CRP, F5, HP, SERPING1

Drugs & Therapeutics for Acquired Angioedema

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Drugs for Acquired Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Desloratadineapproved, investigationalPhase 470100643-71-8124087
Synonyms:
100643-71-8
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-chloro-6,11-dihydro-11-(4-Piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
AC-1279
AC1L3XUD
AKOS000280921
Aerius
Allex
Azomyr
BB_SC-2104
C121345
CHEBI:291342
CHEMBL1172
CID124087
CPD000149358
Claramax
Clarinex
Clarinex (TN)
Clarinex RediTabs
Clarinex Reditabs
D03693
D3787
DB00967
DESLORATADINE
Denosin
Desalex
Descarboethoxyloratadine
Descarboethoxyoratidine
 
Desloratadine
Desloratadine (USAN/INN)
Desloratadine [USAN]
Desloratidine
Essex brand of desloratadine
HMS2052H05
HMS2090C06
HMS2093F19
I06-1866
L001025
LS-181814
MLS000559042
MLS000759406
MLS001201801
MolPort-000-883-875
NCGC00159325-02
NCGC00159325-03
NCGC00159325-04
NSC675447
NeoClarityn
Neoclarityn
Opulis
SAM001246545
SMR000149358
STK586537
Sch 34117
Sch-34117
Schering brand of desloratadine
Schering-Plough brand of desloratadine
TL8000065
UNII-FVF865388R
desloratadine
2
LoratadineapprovedPhase 410079794-75-53957
Synonyms:
1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester
4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
79794-75-5
AC-2086
AC1L1H3E
Aerotina
Alarin
Alavert
Alavert, Claritin, Loratadine
Alerpriv
Allertidin
Amantadine
Anhissen
BB_SC-2109
BIDD:GT0198
BRD-K82795137-001-02-3
BRD-K82795137-001-10-6
BSPBio_002300
Bedix Loratadina
Biloina
Bonalerg
C22H23ClN2O2
CHEMBL998
CID3957
CPD000058255
Children's Claritin
Civeran
Claratyne
Claratyne Cold
Claratyne Decongestant
Clarinase
Clarinase Reperabs
Claritin
Claritin (TN)
Claritin D
Claritin Hives Relief
Claritin Hives Relief Reditab
Claritin Reditabs
Claritin reditab
Claritine
Clarityn
Clarityne
Clarityne Dy Repetabs
Clarityne-D
Clarium
Cronopen
D00364
D017336
DB00455
DivK1c_000792
EU-0100680
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate
Flonidan
Fristamin
HMS2051G11
HMS2090O18
HMS2093I15
HMS502H14
HSDB 3578
Histaloran
I14-0747
IDI1_000792
KBio1_000792
KBio2_001976
KBio2_004544
KBio2_007112
KBio3_001520
KBioGR_000693
KBioSS_001976
Klaritin
L 9664
L000667
L0223
L9664_SIGMA
LS-114660
 
Lergy
Lertamine
Lesidas
Lisino
Lopac-L-9664
Lopac0_000680
Loracert
Loradex
Loradif
Loranox
Lorantis
Lorastine
Loratadina
Loratadina [Spanish]
Loratadine
Loratadine (JAN/USAN/INN)
Loratadine Redidose
Loratadine Wyeth Brand
Loratadine [USAN:BAN:INN]
Loratadinum
Loratadinum [Latin]
Loratidine
Loratyne
Loraver
Lorfast
Loritine
Lowadina
MLS000069647
MLS000758260
MLS001148466
MolPort-002-507-846
NCGC00015619-01
NCGC00015619-02
NCGC00015619-06
NCGC00015619-10
NCGC00023125-02
NCGC00023125-04
NCGC00023125-05
NCGC00023125-06
NCGC00023125-07
NCI60_041473
NINDS_000792
NSC721075
Nularef
Oprea1_027965
Optimin
Polaratyne
Pylor
Restamine
Rhinase
Rinomex
Roletra
S1358_Selleck
SAM001246987
SMR000058255
SPBio_001548
SPECTRUM1503712
STK574925
Sanelor
Sch 29851
Sch-29851
Sch29851
Sensibit
Sinhistan Dy
Sohotin
Spectrum2_001584
Spectrum3_000740
Spectrum4_000177
Spectrum5_001650
Spectrum_001496
TL8005389
Tadine
Talorat Dy
Tocris-1944
UNII-7AJO3BO7QN
Velodan
Versal
Wyeth Brand of Loratadine
ZINC00537931
Zeos
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
loratadine
3
Histamineapproved, investigationalPhase 4105075614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-(4-imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
4-imidazoleethylamine
5-Imidazoleethylamine
5-imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminoethylglyoxaline
beta-aminoethylimidazole
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
4Histamine H1 Antagonists, Non-SedatingPhase 4359
5Anti-Allergic AgentsPhase 41522
6Neurotransmitter AgentsPhase 418340
7Histamine H1 AntagonistsPhase 4791
8
Histamine PhosphatePhase 4104951-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
LS-78569
UNII-QWB37T4WZZ
9Histamine AntagonistsPhase 4961
10AntipruriticsPhase 4841
11Cholinergic AgentsPhase 43992
12Dermatologic AgentsPhase 45806
13Cholinergic AntagonistsPhase 41706
14Complement System ProteinsPhase 2, Phase 3232
15Immunosuppressive AgentsPhase 2, Phase 313086
16Complement C1 Inhibitor ProteinPhase 2, Phase 352
17Complement Inactivating AgentsPhase 2, Phase 396
18Complement C1 Inactivator ProteinsPhase 2, Phase 351
19Vasodilator Agents3543
20Kininogens50
21Complement C1s32
22
Bradykinin5058-82-2439201
Synonyms:
Callidin I
Kallidin 9
 
Kallidin I
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
L-Bradykinin

Interventional clinical trials:

idNameStatusNCT IDPhase
1Desloratadine 5, 10 and 20mg in Patients With Cold UrticariaCompletedNCT01444196Phase 4
2C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125541Phase 2, Phase 3
3C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125151Phase 3
4Kinetics, Efficacy and Safety of C1-Esteraseremmer-NCompletedNCT00119431Phase 2
5Biomarker for Hereditary Angioedema Disease Type 1RecruitingNCT03029728
6Determination of Specific Biomarkers of Angioneurotic CrisisRecruitingNCT02833675

Search NIH Clinical Center for Acquired Angioedema

Genetic Tests for Acquired Angioedema

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Anatomical Context for Acquired Angioedema

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MalaCards organs/tissues related to Acquired Angioedema:

36
B cells, Tongue, Testes, Skin, Colon

Publications for Acquired Angioedema

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Articles related to Acquired Angioedema:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Rituximab in a patient with splenic marginal zone lymphoma and acquired angioedema. (27017557)
2016
2
A case of acquired angioedema possibly associated with adenocarcinoma of the colon. (27026513)
2016
3
Shortened Activated Partial Thromboplastin Time May Help in Diagnosing Hereditary and Acquired Angioedema. (27463190)
2016
4
Perioperative course in patients with hereditary or acquired angioedema. (27687418)
2016
5
Comparing acquired angioedema with hereditary angioedema (type I/II): Findings from the Icatibant Outcome Survey. (27936514)
2016
6
The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity. (26068904)
2015
7
Non-myeloablative allogeneic stem cell transplantation: a new treatment option for acquired angioedema? (26478549)
2015
8
A UK national audit of hereditary and acquired angioedema. (23786259)
2014
9
An evidence based therapeutic approach to hereditary and acquired angioedema. (24983294)
2014
10
Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema. (25506230)
2014
11
Acquired angioedema with C1 inhibitor deficiency secondary to splenic marginal zone B-cell lymphoma. (24970460)
2014
12
Use of recombinant C1 inhibitor in patients with resistant or frequent attacks of hereditary or acquired angioedema. (24556385)
2014
13
New perspectives in acquired angioedema. (24979839)
2014
14
Acquired angioedema--occurrence, clinical features and associated disorders in a Danish nationwide patient cohort. (23921495)
2013
15
A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema. (24352125)
2013
16
A patient with chronic lymphocytic leukemia and acquired angioedema: correlation of clinical and biochemical response to CLL therapy. (23441138)
2013
17
Acquired angioedema with raised serum tryptase. (23244664)
2013
18
International consensus on hereditary and acquired angioedema. (23176876)
2012
19
Acquired angioedema and marginal zone lymphoma. (22508826)
2012
20
Chapter 22: Hereditary and acquired angioedema. (22794695)
2012
21
Acquired angioedema with C1 inhibitor deficiency associated with anticardiolipin antibodies. (22230421)
2011
22
Treatment of acquired angioedema with icatibant: a case report. (20680518)
2011
23
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
24
Acquired angioedema responding to rituximab. (21691703)
2011
25
Surgical" abdomen in a patient with chronic lymphocytic leukemia: a case of acquired angioedema. (21997434)
2011
26
Update on laboratory tests for the diagnosis and differentiation of hereditary angioedema and acquired angioedema. (22195757)
2011
27
Rapid resolution of erythema marginatum after icatibant in acquired angioedema. (21279303)
2011
28
Successful use of etanercept in acquired angioedema in a patient with psoriatic arthritis. (20040647)
2010
29
Acquired angioedema. (20667117)
2010
30
Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. (20929611)
2010
31
Optimal medical management of acute attacks of acquired angioedema. (20042567)
2010
32
Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. (18204284)
2008
33
Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. (18447143)
2008
34
Acute upper airway obstruction from acquired angioedema. (17305664)
2007
35
Acquired angioedema in non-Hodgkin's lymphoma. (17317233)
2007
36
Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation. (16472576)
2006
37
Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency. (16630950)
2006
38
Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency. (16887400)
2006
39
Deep venous thrombosis associated with acquired angioedema type II in a patient heterozygous for the mutation of factor V Leiden: effective treatment and follow-up for four years. (16676085)
2006
40
Acquired angioedema secondary to hormone replacement therapy. (16272680)
2005
41
Hereditary and acquired angioedema: experience with patients in Puerto Rico. (15125214)
2004
42
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. (15356535)
2004
43
Acquired angioedema: a new target for rituximab? (15339702)
2004
44
Hereditary and acquired angioedema. (15515380)
2004
45
Acquired angioedema and Helicobacter pylori infection in a child. (12898238)
2003
46
Profhylaxis and treatment of hereditary and acquired angioedema at HUB; use of the C1-esterase inhibitor]. (14974880)
2003
47
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
48
Polyclonal autoantibodies against C1 inhibitor in a case of acquired angioedema. (12086372)
2002
49
Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2. (12208377)
2002
50
Anaplastic large cell lymphoma and acquired angioedema: a novel association? (12402660)
2002

Variations for Acquired Angioedema

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Expression for genes affiliated with Acquired Angioedema

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Search GEO for disease gene expression data for Acquired Angioedema.

Pathways for genes affiliated with Acquired Angioedema

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GO Terms for genes affiliated with Acquired Angioedema

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Cellular components related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5F5, SERPING1
2blood microparticleGO:00725629.0C1S, C3, HP, SERPING1
3extracellular exosomeGO:00700628.4C1S, C3, CRP, HP, SERPING1
4extracellular spaceGO:00056158.1C3, CRP, F5, HP, SERPING1
5extracellular regionGO:00055767.8C1S, C3, CRP, F5, HP, SERPING1

Biological processes related to Acquired Angioedema according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:000801510.3F5, SERPING1
2hemostasisGO:000759910.3F5, SERPING1
3platelet degranulationGO:000257610.2F5, SERPING1
4complement activationGO:000695610.1C1S, C3
5acute-phase responseGO:00069539.9CRP, HP
6complement activation, classical pathwayGO:00069589.7C1S, C3, SERPING1
7immune system processGO:00023769.7C1S, C3, SERPING1
8innate immune responseGO:00450879.7C1S, C3, SERPING1
9regulation of complement activationGO:00304499.0C1S, C3, SERPING1
10proteolysisGO:00065088.6C1S, C3, F5, HP

Molecular functions related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042528.1C1S, C3, F5, HP

Sources for Acquired Angioedema

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
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