MCID: ACQ012
MIFTS: 35

Acquired Angioedema malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Skin diseases

Aliases & Classifications for Acquired Angioedema

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acquired Angioedema:

Name: Acquired Angioedema 45 51 65
Acquired C1 Inhibitor Deficiency 45 51
Acquired Non Histamine-Induced Angioedema 51
Acquired Bradykinine-Induced Angioedema 51
 
Acquired Angioneurotic Edema 51
Angioedema, Acquired 45
Aae 51

Characteristics:

Orphanet epidemiological data:

51
acquired angioedema:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet51 91385
ICD10 via Orphanet28 T78.3
MESH via Orphanet37 C538173
UMLS via Orphanet66 C2931758
UMLS65 C2931758

Summaries for Acquired Angioedema

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NIH Rare Diseases:45 Acquired angioedema (aae) is a rare condition characterized by recurrent episodes of swelling (edema). affected people may have swelling of the face, lips, tongue, limbs, and genitals. sometimes there is abdominal pain due to edema of the gastrointestinal mucosa, and life-threatening edema of the upper respiratory tract. swelling episodes may be triggered by mild trauma (e.g., dental work), viral illness, cold exposure, pregnancy, ingestion of certain foods, or emotional stress. there are two forms of aae: type i and type ii. aae type i is most commonly associated with b-cell lymphoproliferative disorders and consumption of c1-inh.  aae type ii is an autoimmune condition associated with the presence of an autoantibody against c1-inh. treatment aims to control episodes and normalize c1-inh levels. when possible, the underlying disorder should be treated. last updated: 8/25/2014

MalaCards based summary: Acquired Angioedema, also known as acquired c1 inhibitor deficiency, is related to acquired angioedema type 1 and acquired angioedema type 2, and has symptoms including urticaria, cutaneous edema and acute abdominal pain/colic. An important gene associated with Acquired Angioedema is SERPING1 (Serpin Family G Member 1), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Immune response Lectin induced complement pathway. Affiliated tissues include b cells, tongue and bone.

Related Diseases for Acquired Angioedema

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Graphical network of the top 20 diseases related to Acquired Angioedema:



Diseases related to acquired angioedema

Symptoms for Acquired Angioedema

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Symptoms:

 51
  • urticaria
  • cutaneous edema
  • acute abdominal pain/colic
  • angioedema/angioneurotic edema
  • intestinal obstruction/ileus
  • severe allergic reaction/atopy

Drugs & Therapeutics for Acquired Angioedema

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Drugs for Acquired Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Histamine PhosphateapprovedPhase 490651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
2
Desloratadineapproved, investigationalPhase 469100643-71-8124087
Synonyms:
100643-71-8
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8-chloro-6,11-dihydro-11-(4-Piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
AC-1279
AC1L3XUD
AKOS000280921
Aerius
Allex
Azomyr
BB_SC-2104
C121345
CHEBI:291342
CHEMBL1172
CID124087
CPD000149358
Claramax
Clarinex
Clarinex (TN)
Clarinex RediTabs
Clarinex Reditabs
D03693
D3787
DB00967
DESLORATADINE
Denosin
Desalex
Descarboethoxyloratadine
Descarboethoxyoratidine
 
Desloratadine
Desloratadine (USAN/INN)
Desloratadine [USAN]
Desloratidine
Essex brand of desloratadine
HMS2052H05
HMS2090C06
HMS2093F19
I06-1866
L001025
LS-181814
MLS000559042
MLS000759406
MLS001201801
MolPort-000-883-875
NCGC00159325-02
NCGC00159325-03
NCGC00159325-04
NSC675447
NeoClarityn
Neoclarityn
Opulis
SAM001246545
SMR000149358
STK586537
Sch 34117
Sch-34117
Schering brand of desloratadine
Schering-Plough brand of desloratadine
TL8000065
UNII-FVF865388R
desloratadine
3Histamine H1 Antagonists, Non-SedatingPhase 4323
4Neurotransmitter AgentsPhase 414795
5Histamine H1 AntagonistsPhase 4688
6Histamine AntagonistsPhase 4826
7Cholinergic AntagonistsPhase 41423
8
histaminePhase 490675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
9Cholinergic AgentsPhase 43243
10Complement System ProteinsPhase 2, Phase 3190

Interventional clinical trials:

idNameStatusNCT IDPhase
1Desloratadine 5, 10 and 20mg in Patients With Cold UrticariaCompletedNCT01444196Phase 4
2C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125541Phase 2, Phase 3
3C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125151Phase 3
4Kinetics, Efficacy and Safety of C1-Esteraseremmer-NCompletedNCT00119431Phase 2

Search NIH Clinical Center for Acquired Angioedema

Genetic Tests for Acquired Angioedema

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Anatomical Context for Acquired Angioedema

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MalaCards organs/tissues related to Acquired Angioedema:

33
B cells, Tongue, Bone, Brain, Liver, Neutrophil, T cells

Animal Models for Acquired Angioedema or affiliated genes

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Publications for Acquired Angioedema

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Articles related to Acquired Angioedema:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Reducing the risk of legionellosis in stem cell transplant recipients. (25581611)
2015
2
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. (26314415)
2015
3
The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis. (25837760)
2015
4
Carrier status of leptospirosis among cattle in sri lanka: a zoonotic threat to public health. (22998409)
2014
5
Correction: distinct distribution pattern of hepatitis B virus genotype C and d in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. (25333638)
2014
6
Simulating real world functioning in schizophrenia using a naturalistic city environment and single-trial, goal-directed navigation. (24324418)
2013
7
Spinal cord compression in pseudohypoparathyroidism. (24060230)
2013
8
The uveitis and its relationship with disease activity and quality of life in Moroccan children with juvenile idiopathic arthritis. (23636793)
2013
9
Spontaneous splenic rupture in infectious mononucleosis. (24224308)
2013
10
Rapid-developed primary malignant myoepithelioma in the cavernous sinus: a case report. (23642050)
2013
11
Acellular dermal matrix in cleft palate repair: an evidence-based review. (22743882)
2012
12
In vivo effect of glucose-dependent insulinotropic peptide (GIP) on the gene expression of calcitonin peptides in human subcutaneous adipose tissue. (22960196)
2012
13
Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. (20940296)
2011
14
Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. (21832969)
2011
15
Middle cerebral artery occlusion model in rodents: methods and potential pitfalls. (21331357)
2011
16
Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity. (21402675)
2011
17
The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. (21233283)
2011
18
A child with an FGFR3 mutation, a laterality disorder and an hepatoblastoma: novel associations and possible gene-environment interactions. (20707699)
2010
19
IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site. (19699527)
2009
20
Indoleamine 2,3-dioxygenase expression and regulation in chronic periodontitis. (19228097)
2009
21
Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. (18668543)
2008
22
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. (18039710)
2008
23
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. (17999461)
2007
24
Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis. (16601211)
2006
25
Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. (16705673)
2006
26
Plasma atrial natriuretic Peptide and brain natriuretic Peptide levels after radiofrequency catheter ablation of atrial fibrillation. (16765125)
2006
27
Fulminant neurological deterioration in a neonate with Leigh syndrome due to a maternally transmitted missense mutation in the mitochondrial ND3 gene. (16023078)
2005
28
Hepatosplenic alphabeta T-cell lymphoma with myelodysplastic syndrome. (16146847)
2005
29
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. (15368493)
2004
30
Further delineation of the Toriello-Carey syndrome: a report of two siblings. (12494442)
2003
31
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. (12954072)
2003
32
Interactions between aromatase (estrogen synthase) and dopamine in the control of male sexual behavior in quail. (11997208)
2002
33
Pattern and significance of white matter abnormalities in myotonic dystrophy type 1: an MRI study. (12242535)
2002
34
Neurologic, ophthalmic, and neuropsychiatric manifestations of pediatric systemic lupus erythematosus. (10966064)
2000
35
Ultrasonographic prenatal diagnosis of microcephalic osteodysplastic primordial dwarfism types I/III. (10951479)
2000
36
Influence of development and aging on brain biopterin: implications for dopa-responsive dystonia onset. (9710058)
1998
37
Adult respiratory distress syndrome in patients with malignant astrocytoma--three case reports. (9259158)
1997
38
Streptococcus suis toxic-shock syndrome and meningitis. (9078819)
1997
39
Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. (9467378)
1997
40
Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes. (8631897)
1996
41
The effect of c-raf antisense oligonucleotides on growth factor-induced proliferation of hematopoietic cells. (8585963)
1996
42
Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. (9041124)
1996
43
Expression of the two iduronate-2-sulfatase cDNAs. (7663435)
1995
44
Binding properties of coumestrol to expressed human estrogen receptor. (8674866)
1995
45
Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera. (8081000)
1994
46
Recurrent erythema multiforme: tissue typing in a large series of patients. (7947205)
1994
47
Clinical usefulness of rheumatoid factor in synovial fluid. Re-evaluation]. (8085060)
1993
48
Ligand-dependent quenching of tryptophan fluorescence in human erythrocyte hexose transport protein. (2340286)
1990
49
Lymphangiosarcoma in postmastectomy lymphedema (Stewart-Treves syndrome): ultrastructural and immunohistologic characteristics. (2842548)
1988
50
Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells. (2822677)
1987

Variations for Acquired Angioedema

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Expression for genes affiliated with Acquired Angioedema

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Search GEO for disease gene expression data for Acquired Angioedema.

GO Terms for genes affiliated with Acquired Angioedema

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Cellular components related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.0C1S, SERPING1

Biological processes related to Acquired Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:00450879.0C1S, SERPING1

Sources for Acquired Angioedema

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet