MCID: ACQ012
MIFTS: 38

Acquired Angioedema malady

Genetic diseases, Rare diseases, Skin diseases, Bone diseases, Immune diseases categories
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Summaries for Acquired Angioedema

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33MalaCards
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MalaCards: Acquired Angioedema, also known as angioedema,acquired, is related to angioedema and c1 inhibitor deficiency. An important gene associated with Acquired Angioedema is C1S (complement component 1, s subcomponent), and among its related pathways are Pertussis and Complement Pathway. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Aliases & Classifications for Acquired Angioedema

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43NIH Rare Diseases, 62UMLS
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Classifications:



Aliases & Descriptions:

acquired angioedema 43 62
angioedema,acquired 43


Related Diseases for Acquired Angioedema

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17GeneCards, 18GeneDecks
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Diseases in the Angioedema, Hereditary, Types I and Ii family:

Hereditary Angioedema Angioedema
acquired angioedema Hereditary Angioedema Type Iii
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Acquired Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1angioedema31.5SERPING1, C1S
2c1 inhibitor deficiency30.8SERPING1
3hereditary angioedema30.5C1S, SERPING1
4antithrombin iii deficiency30.1SERPINC1, F5
5antiphospholipid syndrome30.1SERPINC1, F5
6thromboembolism30.1F5, SERPINC1
7venous thrombosis30.1F5, SERPINC1
8acquired angioedema type 210.3
9chronic lymphocytic leukemia10.2
10leukemia10.2
11angioedema induced by ace inhibitors10.2
12acquired angioedema type 110.2
13branch retinal artery occlusion10.1F5
14central retinal vein occlusion10.1F5
15sneddon syndrome10.1SERPINC1
16hepatitis c10.1
17autoimmune hemolytic anemia10.1
18psoriatic arthritis10.1
19anaplastic large cell lymphoma10.1
20arthritis10.1
21hemolytic anemia10.1
22hepatitis10.1
23hodgkin's lymphoma10.1
24myelofibrosis10.1
25castleman's disease10.1
26venous thromboembolism10.1
27sinusitis10.1
28coronary thrombosis10.1SERPINC1
29eclampsia10.1SERPINC1
30capillary leak syndrome10.0SERPING1, C1S
31purpura fulminans10.0F5, SERPINC1
32post-thrombotic syndrome10.0SERPINC1, F5
33legg-calve-perthes disease10.0F5, SERPINC1
34prothrombin deficiency10.0SERPINC1, F5
35hepatic vein thrombosis10.0SERPINC1, F5
36urticaria10.0SERPING1, C1S
37sagittal sinus thrombosis10.0F5, SERPINC1
38retinal vein occlusion10.0F5, SERPINC1
39blood protein disease10.0F5, SERPINC1
40intracranial thrombosis10.0SERPINC1, F5
41portal vein thrombosis10.0SERPINC1, F5
42factor xii deficiency10.0F5, SERPINC1
43severe pre-eclampsia10.0SERPINC1, F5
44dysfibrinogenemia10.0F5, SERPINC1
45meningococcemia10.0SERPINC1, F5
46hemorrhagic disease10.0SERPINC1, F5
47placental abruption10.0SERPINC1, F5
48hellp syndrome10.0SERPINC1, F5
49factor vii deficiency10.0F5, SERPINC1
50factor viii deficiency10.0SERPINC1, F5

Graphical network of the top 20 diseases related to Acquired Angioedema:



Diseases related to acquired angioedema

Symptoms for Acquired Angioedema

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Drugs & Therapeutics for Acquired Angioedema

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Acquired Angioedema

Search NIH Clinical Center for Acquired Angioedema

Genetic Tests for Acquired Angioedema

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Anatomical Context for Acquired Angioedema

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33MalaCards
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MalaCards organs/tissues related to Acquired Angioedema:

33
Skin, Testes

Animal Models for Acquired Angioedema or affiliated genes

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Publications for Acquired Angioedema

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52PubMed
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Articles related to Acquired Angioedema:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
A UK national audit of hereditary and acquired angioedema. (23786259)
2014
2
A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema. (24352125)
2013
3
Acquired angioedema with raised serum tryptase. (23244664)
2013
4
Acquired angioedema--occurrence, clinical features and associated disorders in a Danish nationwide patient cohort. (23921495)
2013
5
Chapter 22: Hereditary and acquired angioedema. (22794695)
2012
6
Acquired angioedema and marginal zone lymphoma. (22508826)
2012
7
International consensus on hereditary and acquired angioedema. (23176876)
2012
8
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
9
"Surgical" abdomen in a patient with chronic lymphocytic leukemia: a case of acquired angioedema. (21997434)
2011
10
Rapid resolution of erythema marginatum after icatibant in acquired angioedema. (21279303)
2011
11
Acquired angioedema with C1 inhibitor deficiency associated with anticardiolipin antibodies. (22230421)
2011
12
Treatment of acquired angioedema with icatibant: a case report. (20680518)
2011
13
Acquired angioedema responding to rituximab. (21691703)
2011
14
Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. (20929611)
2010
15
Acquired angioedema. (20667117)
2010
16
Successful use of etanercept in acquired angioedema in a patient with psoriatic arthritis. (20040647)
2010
17
Optimal medical management of acute attacks of acquired angioedema. (20042567)
2010
18
Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. (18204284)
2008
19
Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. (18447143)
2008
20
Acute upper airway obstruction from acquired angioedema. (17305664)
2007
21
Acquired angioedema in non-Hodgkin's lymphoma. (17317233)
2007
22
Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency. (16887400)
2006
23
Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation. (16472576)
2006
24
Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency. (16630950)
2006
25
Acquired angioedema secondary to hormone replacement therapy. (16272680)
2005
26
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. (15356535)
2004
27
Hereditary and acquired angioedema: experience with patients in Puerto Rico. (15125214)
2004
28
Acquired angioedema: a new target for rituximab? (15339702)
2004
29
Hereditary and acquired angioedema. (15515380)
2004
30
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
31
Acquired angioedema and Helicobacter pylori infection in a child. (12898238)
2003
32
Profhylaxis and treatment of hereditary and acquired angioedema at HUB; use of the C1-esterase inhibitor]. (14974880)
2003
33
Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2. (12208377)
2002
34
Anaplastic large cell lymphoma and acquired angioedema: a novel association? (12402660)
2002
35
Polyclonal autoantibodies against C1 inhibitor in a case of acquired angioedema. (12086372)
2002
36
Acquired angioedema associated with sinusitis. (10923586)
2000
37
Acquired angioedema associated with chronic hepatitis C. (10200025)
1999
38
Hereditary or acquired angioedema caused by functional deficiency of C1 inhibitor--a still unfamiliar disease picture]. (10093876)
1999
39
Acquired angioedema. (9092748)
1997
40
Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid. (8182230)
1994
41
Immunoadsorption in acquired angioedema: a therapeutic misadventure. (8453789)
1993
42
Acquired angioedema as the presenting feature of lymphoproliferative disorders of mature B-lymphocytes. (8242559)
1993
43
Replacement therapy in hereditary and acquired angioedema. (1409286)
1992
44
C1 inhibitor deficiency: molecular and immunologic basis of hereditary and acquired angioedema. (1921329)
1991
45
Acquired angioedema: observations on the mechanism of action of autoantibodies directed against C1 esterase inhibitor. (2454251)
1988
46
Acquired angioedema. (3203091)
1988
47
Electrophoretic differentiation of acquired angioedema from hereditary angioedema. (3568427)
1987
48
Acquired angioedema and hypocompleentemia in a patient with myelofibrosis. Effect of danazol treatment. (6899952)
1980
49
Acquired angioedema associated with rectal carcinoma and its response to danazol therapy. Acquired angioedema treated with danazol. (701655)
1978
50
Acquired angioedema with lymphoproliferative disorder: association of C1 inhibitor deficiency with cellular abnormality. (1085645)
1976

Variations for Acquired Angioedema

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Expression for genes affiliated with Acquired Angioedema

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Angioedema

Search GEO for disease gene expression data for Acquired Angioedema.

Pathways for genes affiliated with Acquired Angioedema

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50PathCards, 30KEGG, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological, 38NCBI BioSystems Database, 54R&D Systems
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Pathways related to Acquired Angioedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SERPING1, C1S
2
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.3SERPING1, C1S
3
Show member pathways
9.3F5, SERPING1
4
Show member pathways
9.1F5, SERPINC1
5
Show member pathways
8.5F5, SERPINC1, SERPING1
6
Show member pathways
8.5SERPING1, SERPINC1, F5
7
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.0F5, SERPINC1, SERPING1, C1S

Compounds for genes affiliated with Acquired Angioedema

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Acquired Angioedema according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1inogatran459.6SERPINC1, F5
2hirugen459.6F5, SERPINC1
3ecarin459.6F5, SERPINC1
4spectrozyme459.6SERPINC1, F5
5nafamostat mesilate459.6F5, SERPINC1
6danaparoid459.6F5, SERPINC1
7ximelagatran45 1110.5SERPINC1, F5
8ancrod459.5SERPINC1, F5
9heparinoids459.5SERPINC1, F5
10fondaparinux459.5F5, SERPINC1
11bivalirudin45 1110.5SERPINC1, F5
12argatroban45 1110.5F5, SERPINC1
13desogestrel45 1110.5F5, SERPINC1
14gabexate mesilate459.5F5, SERPINC1
15tranexamic acid45 1110.5C1S, SERPINC1
16protamine sulfate459.5SERPINC1, F5
17gestodene45 1110.5F5, SERPINC1
18eltrombopag51 1110.5SERPINC1, F5
19benzamidine45 1110.5F5, SERPINC1
20ristocetin459.5SERPINC1, F5
21tibolone459.5F5, SERPINC1
22levonorgestrel45 61 29 1112.5F5, SERPINC1
23abciximab45 1110.4SERPINC1, C1S
24desmopressin45 61 29 1112.4SERPINC1, F5
25coumarin45 3 51 2412.4SERPINC1, F5
26fluorescein45 1110.4F5, SERPINC1
27hirudin459.4F5, SERPINC1
28protamine459.4SERPINC1, F5
29dermatan sulfate459.4F5, SERPINC1
30raloxifene45 51 29 1112.4F5, SERPINC1
31dextran sulfate459.3SERPINC1, F5
32warfarin45 51 24 1112.3F5, SERPINC1
33progestin459.2SERPINC1, F5
34polyethylene glycol459.1F5, SERPINC1
35folate459.1F5, SERPINC1
36kininogen459.1F5, SERPINC1, C1S
37aprotinin45 1110.0F5, SERPINC1, C1S
38homocysteine45 2410.0SERPINC1, F5
39prostacyclin459.0F5, SERPINC1, C1S
40aspirin45 51 29 2412.0F5, SERPINC1, C1S
41fibrinogen459.0F5, SERPINC1, C1S
42danazol45 24 1111.0SERPINC1, SERPING1, C1S
43citrate458.8F5, SERPINC1
44arginine458.8F5, SERPINC1, C1S
45alanine458.6F5, SERPINC1, SERPING1
46heparin45 29 24 1111.4C1S, SERPING1, SERPINC1, F5
47serine458.3C1S, SERPING1, SERPINC1, F5

GO Terms for genes affiliated with Acquired Angioedema

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16Gene Ontology
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Cellular components related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0F5, SERPING1
2blood microparticleGO:0725628.5SERPINC1, SERPING1, C1S
3extracellular spaceGO:0056158.5F5, SERPINC1, SERPING1
4extracellular regionGO:0055767.9C1S, SERPING1, SERPINC1, F5

Biological processes related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.4F5, SERPING1
2complement activation, classical pathwayGO:0069589.3C1S, SERPING1
3platelet activationGO:0301689.3F5, SERPING1
4platelet degranulationGO:0025769.2F5, SERPING1
5negative regulation of endopeptidase activityGO:0109518.7SERPINC1, SERPING1
6blood coagulationGO:0075968.6F5, SERPINC1, SERPING1

Molecular functions related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.4F5, C1S
2serine-type endopeptidase inhibitor activityGO:0048678.7SERPINC1, SERPING1

Products for genes affiliated with Acquired Angioedema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Angioedema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet