MCID: ACQ012
MIFTS: 38

Acquired Angioedema malady

Genetic diseases, Rare diseases, Skin diseases, Bone diseases, Immune diseases categories

Summaries for Acquired Angioedema

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34MalaCards
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MalaCards: Acquired Angioedema, also known as angioedema,acquired, is related to angioedema and c1 inhibitor deficiency. An important gene associated with Acquired Angioedema is C1S (complement component 1, s subcomponent), and among its related pathways are Pertussis and Complement Pathway. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Aliases & Classifications for Acquired Angioedema

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44NIH Rare Diseases, 63UMLS
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Classifications:



Aliases & Descriptions:

acquired angioedema 44 63
angioedema,acquired 44


Related Diseases for Acquired Angioedema

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18GeneCards, 19GeneDecks
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Diseases in the Angioedema, Hereditary, Types I and Ii family:

Hereditary Angioedema Angioedema
acquired angioedema Hereditary Angioedema Type Iii
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Acquired Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1angioedema31.5SERPING1, C1S
2c1 inhibitor deficiency30.8SERPING1
3hereditary angioedema30.5C1S, SERPING1
4antithrombin iii deficiency30.1SERPINC1, F5
5antiphospholipid syndrome30.1SERPINC1, F5
6thromboembolism30.1F5, SERPINC1
7venous thrombosis30.1F5, SERPINC1
8acquired angioedema type 210.3
9chronic lymphocytic leukemia10.2
10leukemia10.2
11angioedema induced by ace inhibitors10.2
12acquired angioedema type 110.2
13branch retinal artery occlusion10.1F5
14central retinal vein occlusion10.1F5
15sneddon syndrome10.1SERPINC1
16hepatitis c10.1
17autoimmune hemolytic anemia10.1
18psoriatic arthritis10.1
19anaplastic large cell lymphoma10.1
20arthritis10.1
21hemolytic anemia10.1
22hepatitis10.1
23hodgkin's lymphoma10.1
24myelofibrosis10.1
25castleman's disease10.1
26venous thromboembolism10.1
27sinusitis10.1
28coronary thrombosis10.1SERPINC1
29eclampsia10.1SERPINC1
30capillary leak syndrome10.0SERPING1, C1S
31purpura fulminans10.0F5, SERPINC1
32post-thrombotic syndrome10.0SERPINC1, F5
33legg-calve-perthes disease10.0F5, SERPINC1
34prothrombin deficiency10.0SERPINC1, F5
35hepatic vein thrombosis10.0SERPINC1, F5
36urticaria10.0SERPING1, C1S
37sagittal sinus thrombosis10.0F5, SERPINC1
38retinal vein occlusion10.0F5, SERPINC1
39blood protein disease10.0F5, SERPINC1
40intracranial thrombosis10.0SERPINC1, F5
41portal vein thrombosis10.0SERPINC1, F5
42factor xii deficiency10.0F5, SERPINC1
43severe pre-eclampsia10.0SERPINC1, F5
44dysfibrinogenemia10.0F5, SERPINC1
45meningococcemia10.0SERPINC1, F5
46hemorrhagic disease10.0SERPINC1, F5
47placental abruption10.0SERPINC1, F5
48hellp syndrome10.0SERPINC1, F5
49factor vii deficiency10.0F5, SERPINC1
50factor viii deficiency10.0SERPINC1, F5

Graphical network of the top 20 diseases related to Acquired Angioedema:



Diseases related to acquired angioedema

Symptoms for Acquired Angioedema

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Drugs & Therapeutics for Acquired Angioedema

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acquired Angioedema

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Anatomical Context for Acquired Angioedema

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34MalaCards
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MalaCards organs/tissues related to Acquired Angioedema:

34
Skin, Testes

Animal Models for Acquired Angioedema or affiliated genes

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Publications for Acquired Angioedema

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53PubMed
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Articles related to Acquired Angioedema:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
A UK national audit of hereditary and acquired angioedema. (23786259)
2014
2
A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema. (24352125)
2013
3
Acquired angioedema with raised serum tryptase. (23244664)
2013
4
Acquired angioedema--occurrence, clinical features and associated disorders in a Danish nationwide patient cohort. (23921495)
2013
5
Chapter 22: Hereditary and acquired angioedema. (22794695)
2012
6
Acquired angioedema and marginal zone lymphoma. (22508826)
2012
7
International consensus on hereditary and acquired angioedema. (23176876)
2012
8
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
9
"Surgical" abdomen in a patient with chronic lymphocytic leukemia: a case of acquired angioedema. (21997434)
2011
10
Rapid resolution of erythema marginatum after icatibant in acquired angioedema. (21279303)
2011
11
Acquired angioedema with C1 inhibitor deficiency associated with anticardiolipin antibodies. (22230421)
2011
12
Treatment of acquired angioedema with icatibant: a case report. (20680518)
2011
13
Acquired angioedema responding to rituximab. (21691703)
2011
14
Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. (20929611)
2010
15
Acquired angioedema. (20667117)
2010
16
Successful use of etanercept in acquired angioedema in a patient with psoriatic arthritis. (20040647)
2010
17
Optimal medical management of acute attacks of acquired angioedema. (20042567)
2010
18
Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. (18204284)
2008
19
Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. (18447143)
2008
20
Acute upper airway obstruction from acquired angioedema. (17305664)
2007
21
Acquired angioedema in non-Hodgkin's lymphoma. (17317233)
2007
22
Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency. (16887400)
2006
23
Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation. (16472576)
2006
24
Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency. (16630950)
2006
25
Acquired angioedema secondary to hormone replacement therapy. (16272680)
2005
26
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. (15356535)
2004
27
Hereditary and acquired angioedema: experience with patients in Puerto Rico. (15125214)
2004
28
Acquired angioedema: a new target for rituximab? (15339702)
2004
29
Hereditary and acquired angioedema. (15515380)
2004
30
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
31
Acquired angioedema and Helicobacter pylori infection in a child. (12898238)
2003
32
Profhylaxis and treatment of hereditary and acquired angioedema at HUB; use of the C1-esterase inhibitor]. (14974880)
2003
33
Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2. (12208377)
2002
34
Anaplastic large cell lymphoma and acquired angioedema: a novel association? (12402660)
2002
35
Polyclonal autoantibodies against C1 inhibitor in a case of acquired angioedema. (12086372)
2002
36
Acquired angioedema associated with sinusitis. (10923586)
2000
37
Acquired angioedema associated with chronic hepatitis C. (10200025)
1999
38
Hereditary or acquired angioedema caused by functional deficiency of C1 inhibitor--a still unfamiliar disease picture]. (10093876)
1999
39
Acquired angioedema. (9092748)
1997
40
Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid. (8182230)
1994
41
Immunoadsorption in acquired angioedema: a therapeutic misadventure. (8453789)
1993
42
Acquired angioedema as the presenting feature of lymphoproliferative disorders of mature B-lymphocytes. (8242559)
1993
43
Replacement therapy in hereditary and acquired angioedema. (1409286)
1992
44
C1 inhibitor deficiency: molecular and immunologic basis of hereditary and acquired angioedema. (1921329)
1991
45
Acquired angioedema: observations on the mechanism of action of autoantibodies directed against C1 esterase inhibitor. (2454251)
1988
46
Acquired angioedema. (3203091)
1988
47
Electrophoretic differentiation of acquired angioedema from hereditary angioedema. (3568427)
1987
48
Acquired angioedema and hypocompleentemia in a patient with myelofibrosis. Effect of danazol treatment. (6899952)
1980
49
Acquired angioedema associated with rectal carcinoma and its response to danazol therapy. Acquired angioedema treated with danazol. (701655)
1978
50
Acquired angioedema with lymphoproliferative disorder: association of C1 inhibitor deficiency with cellular abnormality. (1085645)
1976

Variations for Acquired Angioedema

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Expression for genes affiliated with Acquired Angioedema

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Angioedema

Search GEO for disease gene expression data for Acquired Angioedema.

Pathways for genes affiliated with Acquired Angioedema

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51PathCards, 31KEGG, 54QIAGEN, 61Thomson Reuters, 56Reactome, 58SinoBiological, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Acquired Angioedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SERPING1, C1S
2
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.3SERPING1, C1S
3
Show member pathways
9.3F5, SERPING1
4
Show member pathways
9.1F5, SERPINC1
5
Show member pathways
8.5F5, SERPINC1, SERPING1
6
Show member pathways
8.5SERPING1, SERPINC1, F5
7
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.0F5, SERPINC1, SERPING1, C1S

Compounds for genes affiliated with Acquired Angioedema

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46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Acquired Angioedema according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1inogatran469.6SERPINC1, F5
2hirugen469.6F5, SERPINC1
3ecarin469.6F5, SERPINC1
4spectrozyme469.6SERPINC1, F5
5nafamostat mesilate469.6F5, SERPINC1
6danaparoid469.6F5, SERPINC1
7ximelagatran46 1210.5SERPINC1, F5
8ancrod469.5SERPINC1, F5
9heparinoids469.5SERPINC1, F5
10fondaparinux469.5F5, SERPINC1
11bivalirudin46 1210.5SERPINC1, F5
12argatroban46 1210.5F5, SERPINC1
13desogestrel46 1210.5F5, SERPINC1
14gabexate mesilate469.5F5, SERPINC1
15tranexamic acid46 1210.5C1S, SERPINC1
16protamine sulfate469.5SERPINC1, F5
17gestodene46 1210.5F5, SERPINC1
18eltrombopag52 1210.5SERPINC1, F5
19benzamidine46 1210.5F5, SERPINC1
20ristocetin469.5SERPINC1, F5
21tibolone469.5F5, SERPINC1
22levonorgestrel46 62 30 1212.5F5, SERPINC1
23abciximab46 1210.4SERPINC1, C1S
24desmopressin46 62 30 1212.4SERPINC1, F5
25coumarin46 3 52 2512.4SERPINC1, F5
26fluorescein46 1210.4F5, SERPINC1
27hirudin469.4F5, SERPINC1
28protamine469.4SERPINC1, F5
29dermatan sulfate469.4F5, SERPINC1
30raloxifene46 52 30 1212.4F5, SERPINC1
31dextran sulfate469.3SERPINC1, F5
32warfarin46 52 25 1212.3F5, SERPINC1
33progestin469.2SERPINC1, F5
34polyethylene glycol469.1F5, SERPINC1
35folate469.1F5, SERPINC1
36kininogen469.1F5, SERPINC1, C1S
37aprotinin46 1210.0F5, SERPINC1, C1S
38homocysteine46 2510.0SERPINC1, F5
39prostacyclin469.0F5, SERPINC1, C1S
40aspirin46 52 30 2512.0F5, SERPINC1, C1S
41fibrinogen469.0F5, SERPINC1, C1S
42danazol46 25 1211.0SERPINC1, SERPING1, C1S
43citrate468.8F5, SERPINC1
44arginine468.8F5, SERPINC1, C1S
45alanine468.6F5, SERPINC1, SERPING1
46heparin46 30 25 1211.4C1S, SERPING1, SERPINC1, F5
47serine468.3C1S, SERPING1, SERPINC1, F5

GO Terms for genes affiliated with Acquired Angioedema

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17Gene Ontology
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Cellular components related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0F5, SERPING1
2blood microparticleGO:0725628.5SERPINC1, SERPING1, C1S
3extracellular spaceGO:0056158.5F5, SERPINC1, SERPING1
4extracellular regionGO:0055767.9C1S, SERPING1, SERPINC1, F5

Biological processes related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.4F5, SERPING1
2complement activation, classical pathwayGO:0069589.3C1S, SERPING1
3platelet activationGO:0301689.3F5, SERPING1
4platelet degranulationGO:0025769.2F5, SERPING1
5negative regulation of endopeptidase activityGO:0109518.7SERPINC1, SERPING1
6blood coagulationGO:0075968.6F5, SERPINC1, SERPING1

Molecular functions related to Acquired Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.4F5, C1S
2serine-type endopeptidase inhibitor activityGO:0048678.7SERPINC1, SERPING1

Products for genes affiliated with Acquired Angioedema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Angioedema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet