MCID: ACQ027
MIFTS: 27

Acquired Cutis Laxa malady

Categories: Skin diseases, Rare diseases, Genetic diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Fetal diseases, Mental diseases, Bone diseases, Gastrointestinal diseases, Nephrological diseases, Cardiovascular diseases

Aliases & Classifications for Acquired Cutis Laxa

Aliases & Descriptions for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 56
Cutis Laxa, Acquired Type 69
Cutis Laxa Acquisita 56

Characteristics:

Orphanet epidemiological data:

56
acquired cutis laxa
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA228285
UMLS via Orphanet 70 C0406549

Summaries for Acquired Cutis Laxa

MalaCards based summary : Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and multiple myeloma. An important gene associated with Acquired Cutis Laxa is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Acquired Cutis Laxa

Diseases in the Cutis Laxa family:

Cutis Laxa, Ad Cutis Laxa, Autosomal Recessive, Type Iiia
Cutis Laxa, Autosomal Dominant 3 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iia Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Iib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Recessive, Type Ic
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Cutis Laxa, Autosomal Dominant Cutis Laxa, Autosomal Recessive Type 1
Aldh18a1-Related Cutis Laxa Eln-Related Cutis Laxa
Pycr1-Related Cutis Laxa Acquired Cutis Laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
id Related Disease Score Top Affiliating Genes
1 cutis laxa 10.7
2 multiple myeloma 10.3
3 amyloidosis 10.1
4 urticaria 10.0
5 dermatitis 10.0
6 heavy chain deposition disease 10.0
7 arthritis 10.0
8 acute pandysautonomia 9.9 ELN FBLN5
9 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 9.9 ELN FBLN5
10 familial paroxysmal kinesigenic dyskinesia 9.9 ELN FBLN5
11 cystic adventitial disease 9.8 ELN FBLN5
12 keratoacanthoma 9.8 ELN FBLN5
13 lymphoma 9.8
14 nephrotic syndrome 9.8
15 cutaneous mastocytosis 9.8
16 plasmacytoma 9.8
17 granulomatous dermatitis 9.8
18 dermatitis herpetiformis 9.8
19 vasculitis 9.8
20 lupus erythematosus 9.8
21 rheumatoid arthritis 9.8
22 marshall syndrome 9.8
23 mastocytosis 9.8
24 systemic lupus erythematosus 9.8
25 benign focal seizures of adolescence 9.8 ELN FBLN5
26 esophagitis, eosinophilic, 1 9.7 ELN FBLN5

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to Acquired Cutis Laxa

Symptoms & Phenotypes for Acquired Cutis Laxa

Drugs & Therapeutics for Acquired Cutis Laxa

Search Clinical Trials , NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

Anatomical Context for Acquired Cutis Laxa

MalaCards organs/tissues related to Acquired Cutis Laxa:

39
Skin, Neutrophil, T Cells

Publications for Acquired Cutis Laxa

Articles related to Acquired Cutis Laxa:

(show top 50) (show all 52)
id Title Authors Year
1
Generalized acquired cutis laxa type 1: a case report and brief review of literature. ( 27136630 )
2016
2
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. ( 25497952 )
2015
3
Generalized acquired cutis laxa with papular lesions. ( 25516168 )
2015
4
Acquired cutis laxa associated with cutaneous mastocytosis. ( 26436968 )
2015
5
Acquired cutis laxa: diagnostic and therapeutic considerations. ( 25027942 )
2014
6
Acquired cutis laxa of face with multiple myeloma. ( 25201849 )
2014
7
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
8
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. ( 24676529 )
2014
9
Acral localized acquired cutis laxa. ( 23675943 )
2013
10
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. ( 23694828 )
2013
11
Emphysema associated with acquired cutis laxa. ( 23506607 )
2013
12
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. ( 24346874 )
2013
13
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. ( 21810393 )
2011
14
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. ( 21283929 )
2011
15
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. ( 20849517 )
2011
16
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. ( 21422340 )
2011
17
Generalized acquired cutis laxa treated with facial plastic surgery. ( 21252033 )
2011
18
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. ( 20199420 )
2010
19
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. ( 20585600 )
2010
20
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. ( 20574607 )
2010
21
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. ( 21173333 )
2010
22
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. ( 19467378 )
2009
23
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. ( 19438565 )
2009
24
Acquired cutis laxa in childhood Sweet's syndrome. ( 19706111 )
2009
25
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. ( 18191696 )
2008
26
Elastic tissue damage in cephalic acquired cutis laxa. ( 18095996 )
2008
27
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
28
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. ( 16374472 )
2006
29
[Localized acquired cutis laxa associated with trachyonychia]. ( 16476396 )
2005
30
Acquired cutis laxa associated with multiple myeloma. ( 11868975 )
2002
31
Acral localized acquired cutis laxa associated with rheumatoid arthritis. ( 11756959 )
2002
32
Increased fibroblast elastase activity in acquired cutis laxa. ( 10449932 )
1999
33
Post febrile acquired cutis laxa. ( 20885052 )
1999
34
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. ( 9372355 )
1997
35
Acquired cutis laxa associated with a plasma cell dyscrasia. ( 8902101 )
1996
36
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. ( 8776377 )
1996
37
Acrolocalized acquired cutis laxa. ( 8736350 )
1996
38
Acquired cutis laxa associated with chronic urticaria. ( 7593805 )
1995
39
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency. ( 7574835 )
1995
40
Abnormalities of fibrillin in acquired cutis laxa. ( 8188885 )
1994
41
Acquired cutis laxa with dermatitis herpetiformis and sarcoidosis. ( 8408824 )
1993
42
Acquired cutis laxa confined to the face. ( 2061455 )
1991
43
Localized acquired cutis laxa in one of identical twins. ( 2767840 )
1989
44
Acral localized acquired cutis laxa. ( 2745770 )
1989
45
Acquired cutis laxa concomitant with nephrotic syndrome. ( 3307640 )
1987
46
Acquired cutis laxa: case report and review of disorders of elastolysis. ( 4011506 )
1985
47
Acquired cutis laxa and multiple myeloma. ( 6696851 )
1984
48
Multiple myeloma associated with acquired cutis laxa. ( 7408543 )
1980
49
Acquired cutis laxa (generalized elastolysis): light and electron microscopic studies. ( 92145 )
1979
50
Acquired cutis laxa associated with multiple myeloma. ( 942220 )
1976

Variations for Acquired Cutis Laxa

Expression for Acquired Cutis Laxa

Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for Acquired Cutis Laxa

Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 ELN FBLN5
2
Show member pathways
10.49 ELN FBLN5

GO Terms for Acquired Cutis Laxa

Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.96 ELN FBLN5
2 elastic fiber GO:0071953 8.62 ELN FBLN5

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.62 ELN FBLN5

Sources for Acquired Cutis Laxa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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