MCID: ACQ027
MIFTS: 37

Acquired Cutis Laxa malady

Genetic diseases, Skin diseases, Rare diseases, Eye diseases, Bone diseases, Metabolic diseases, Fetal diseases, Gastrointestinal diseases, Nephrological diseases, Neuronal diseases, Cardiovascular diseases categories

Summaries for Acquired Cutis Laxa

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MalaCards based summary: Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and myeloma. An important gene associated with Acquired Cutis Laxa is FBLN5 (fibulin 5), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Elastic fibre formation. The compounds orcein and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and neutrophil, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Acquired Cutis Laxa

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Acquired Cutis Laxa, Aliases & Descriptions:

Name: Acquired Cutis Laxa 47
Cutis Laxa, Acquired Type 60
 
Cutis Laxa Acquisita 47


Classifications:

Orphanet: 47 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

47
cutis laxa acquisita:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 228285
UMLS via Orphanet61 C0406549

Related Diseases for Acquired Cutis Laxa

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Diseases in the Cutis Laxa family:

Cutis Laxa, Autosomal Recessive, Type Iiia Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iia Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Iib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Recessive, Type Ic
Cutis Laxa, Ad Atp6v0a2-Related Cutis Laxa
Efemp2-Related Cutis Laxa Fbln5-Related Cutis Laxa
Cutis Laxa, Autosomal Dominant Cutis Laxa, Autosomal Recessive Type 1
Eln-Related Cutis Laxa Pycr1-Related Cutis Laxa
Aldh18a1-Related Cutis Laxa acquired cutis laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1cutis laxa31.0ELN, ELANE, FBLN5, FBN1
2myeloma10.8
3multiple myeloma10.8
4amyloidosis10.5
5fbln5-related cutis laxa10.4FBLN5
6arthritis10.4
7dermatitis10.4
8heavy chain deposition disease10.4
9aortic disease10.4FBN1
10aortic aneurysm10.4FBN1
11homocysteinemia10.4ELN
12costello syndrome10.3ELN
13cutaneous mastocytosis10.3
14mastocytosis10.3
15rheumatoid arthritis10.3
16marshall syndrome10.3
17systemic lupus erythematosus10.3
18granulomatous dermatitis10.3
19dermatitis herpetiformis10.3
20lupus erythematosus10.3
21nephrotic syndrome10.3
22plasmacytoma10.3
23urticaria10.3
24vasculitis10.3
25emphysema due to aat deficiency10.2ELANE
26aortic valve disease 110.1FBN1, ELN
27thoracic aortic aneurysm10.1FBN1, ELN
28exfoliation syndrome10.1ELN, FBN1
29telangiectasis10.1FBN1, ELN
30pseudoxanthoma elasticum10.1FBN1, ELN
31marfan syndrome10.1ELN, FBN1
32williams-beuren syndrome10.1ELN, FBN1
33hypertrophic scars10.1ELN, FBN1
34ehlers-danlos syndrome10.1FBN1, ELN
35hyperhomocysteinemia10.1FBN1, ELN
36cerebral aneurysms10.0ELN, ELANE
37pulmonary emphysema10.0ELN, ELANE
38acute respiratory distress syndrome10.0ELN, ELANE
39intracranial aneurysm10.0ELANE, ELN
40congenital heart disease10.0ELN, FBN1
41wegener granulomatosis9.9ELN, ELANE
42pulmonary hypertension9.9ELN, ELANE
43mental retardation9.9ELN, FBN1
44supravalvar aortic stenosis9.9FBN1, FBLN5, ELN
45connective tissue disease9.9FBN1, FBLN5, ELN
46pulmonary fibrosis9.9ELN, ELANE
47pulmonary disease, chronic obstructive9.9ELN, ELANE
48cork-handlers' disease9.9ELN, ELANE
49vascular disease9.8ELN, ELANE
50abdominal aortic aneurysm9.8ELN, ELANE, FBN1

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to acquired cutis laxa

Symptoms for Acquired Cutis Laxa

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Drugs & Therapeutics for Acquired Cutis Laxa

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Drug clinical trials:

Search ClinicalTrials for Acquired Cutis Laxa

Search NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

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Anatomical Context for Acquired Cutis Laxa

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MalaCards organs/tissues related to Acquired Cutis Laxa:

31
Skin, T cells, Neutrophil

Animal Models for Acquired Cutis Laxa or affiliated genes

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MGI Mouse Phenotypes related to Acquired Cutis Laxa:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8ELN, FBLN5, FBN1
2MP:00053888.5FBN1, FBLN5, ELN
3MP:00053767.9ELN, ELANE, FBLN5, FBN1

Publications for Acquired Cutis Laxa

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Articles related to Acquired Cutis Laxa:

(show all 49)
idTitleAuthorsYear
1
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. (25497952)
2015
2
Generalized acquired cutis laxa with papular lesions. (25516168)
2015
3
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. (25133950)
2014
4
Acquired cutis laxa of face with multiple myeloma. (25201849)
2014
5
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. (24676529)
2014
6
Acquired cutis laxa: diagnostic and therapeutic considerations. (25027942)
2014
7
Acral localized acquired cutis laxa. (23675943)
2013
8
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. (24346874)
2013
9
Emphysema associated with acquired cutis laxa. (23506607)
2013
10
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. (23694828)
2013
11
Generalized acquired cutis laxa treated with facial plastic surgery. (21252033)
2011
12
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. (21810393)
2011
13
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. (20849517)
2011
14
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. (21283929)
2011
15
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. (21422340)
2011
16
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. (20574607)
2010
17
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. (20585600)
2010
18
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. (20199420)
2010
19
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. (21173333)
2010
20
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. (19467378)
2009
21
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. (19438565)
2009
22
Acquired cutis laxa in childhood Sweet's syndrome. (19706111)
2009
23
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. (18191696)
2008
24
Acquired cutis laxa associated with heavy chain deposition disease. (19119136)
2008
25
Elastic tissue damage in cephalic acquired cutis laxa. (18095996)
2008
26
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. (16374472)
2006
27
Localized acquired cutis laxa associated with trachyonychia]. (16476396)
2005
28
Acral localized acquired cutis laxa associated with rheumatoid arthritis. (11756959)
2002
29
Acquired cutis laxa associated with multiple myeloma. (11868975)
2002
30
Increased fibroblast elastase activity in acquired cutis laxa. (10449932)
1999
31
Post febrile acquired cutis laxa. (20885052)
1999
32
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. (9372355)
1997
33
Acquired cutis laxa associated with a plasma cell dyscrasia. (8902101)
1996
34
Acrolocalized acquired cutis laxa. (8736350)
1996
35
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. (8776377)
1996
36
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency. (7574835)
1995
37
Abnormalities of fibrillin in acquired cutis laxa. (8188885)
1994
38
Acquired cutis laxa with dermatitis herpetiformis and sarcoidosis. (8408824)
1993
39
Acquired cutis laxa confined to the face. (2061455)
1991
40
Localized acquired cutis laxa in one of identical twins. (2767840)
1989
41
Acral localized acquired cutis laxa. (2745770)
1989
42
Acquired cutis laxa concomitant with nephrotic syndrome. (3307640)
1987
43
Acquired cutis laxa: case report and review of disorders of elastolysis. (4011506)
1985
44
Acquired cutis laxa and multiple myeloma. (6696851)
1984
45
Multiple myeloma associated with acquired cutis laxa. (7408543)
1980
46
Acquired cutis laxa (generalized elastolysis): light and electron microscopic studies. (92145)
1979
47
Acquired cutis laxa associated with multiple myeloma. (942220)
1976
48
Acquired cutis laxa. Primary generalized elastolysis. (5555855)
1971
49
Tracheobronchiomegaly and acquired cutis laxa in a child. Physiologic and immunologic studies. (4192682)
1969

Variations for Acquired Cutis Laxa

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Expression for genes affiliated with Acquired Cutis Laxa

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Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for genes affiliated with Acquired Cutis Laxa

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Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ELN, ELANE
2
Show member pathways
8.8ELN, FBLN5, FBN1
3
Show member pathways
8.0ELN, ELANE, FBLN5, FBN1

Compounds for genes affiliated with Acquired Cutis Laxa

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Compounds related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1orcein439.7FBN1, ELN
2cacl2439.7ELN, FBN1
3hydroxyproline43 24 1211.7ELN, FBN1
4chondroitin sulfate43 2410.6FBN1, ELN
5amine439.6FBN1, ELN
6tgf beta1439.5FBN1, ELN
7heparan sulfate43 2410.5ELN, FBN1
8isodesmosine439.4ELN, ELANE
9tannins439.4ELANE, ELN
10(4-aminophenyl)mercuric acetate439.4ELN, ELANE
11thermolysin439.4ELANE, ELN
12diisopropylfluorophosphate439.4ELN, ELANE
13alginate439.4ELN, ELANE
14dermatan sulfate439.4ELN, ELANE
15doxycycline43 1210.4ELN, ELANE
16sodium nitroprusside439.3ELANE, ELN
17hydrocortisone43 2 59 1212.3ELN, ELANE
18carbon439.2ELN, ELANE
19valine439.1ELANE, ELN
20vitamin a43 24 1211.1ELN, ELANE
21chloramphenicol43 2 49 1212.0ELANE, ELN
22ascorbic acid43 2410.0ELN, FBN1
23fibrinogen439.0ELN, ELANE
24desmosine438.9ELN, ELANE, FBN1
25sodium dodecylsulfate438.9ELN, ELANE, FBN1
26hyaluronic acid43 249.9ELN, ELANE, FBN1
27vitamin d438.9FBN1, ELANE, ELN
28heparin43 28 24 1211.9FBN1, ELANE, ELN
29glutamate438.8ELN, ELANE, FBN1
30estrogen438.8ELN, ELANE, FBN1
31retinoic acid43 249.8ELN, ELANE, FBN1
32cysteine438.7FBN1, ELANE, ELN
33serine438.4ELN, ELANE, FBN1

GO Terms for genes affiliated with Acquired Cutis Laxa

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Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.4FBLN5, FBN1
2elastic fiberGO:00719539.3ELN, FBLN5
3proteinaceous extracellular matrixGO:00055788.7ELN, FBLN5, FBN1
4extracellular regionGO:00055767.7FBN1, FBLN5, ELANE, ELN

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:00226178.5ELN, ELANE, FBN1
2extracellular matrix organizationGO:00301987.7ELN, ELANE, FBLN5, FBN1

Molecular functions related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00052019.3ELN, FBN1

Products for genes affiliated with Acquired Cutis Laxa

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Sources for Acquired Cutis Laxa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet