MCID: ACQ027
MIFTS: 29

Acquired Cutis Laxa

Categories: Fetal diseases, Cardiovascular diseases, Rare diseases, Skin diseases, Genetic diseases, Metabolic diseases, Eye diseases, Neuronal diseases, Gastrointestinal diseases, Nephrological diseases, Bone diseases, Mental diseases

Aliases & Classifications for Acquired Cutis Laxa

MalaCards integrated aliases for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 55
Cutis Laxa, Acquired Type 69
Cutis Laxa Acquisita 55

Characteristics:

Orphanet epidemiological data:

55
acquired cutis laxa
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA228285
UMLS via Orphanet 70 C0406549
UMLS 69 C0406549

Summaries for Acquired Cutis Laxa

MalaCards based summary : Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and myeloma, multiple. An important gene associated with Acquired Cutis Laxa is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Acquired Cutis Laxa

Diseases in the Cutis Laxa family:

Cutis Laxa, Autosomal Dominant 1 Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Recessive, Type Iiia Cutis Laxa, Autosomal Recessive, Type Iia
Cutis Laxa, Autosomal Recessive, Type Iib Cutis Laxa, Autosomal Recessive, Type Ic
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Dominant 3
Cutis Laxa, Autosomal Recessive, Type Iic Cutis Laxa, Autosomal Recessive, Type Iid
Cutis Laxa, Autosomal Recessive Type 1 Acquired Cutis Laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 30.5 ELN FBLN5
2 myeloma, multiple 10.5
3 amyloidosis 10.2
4 heavy chain deposition disease 10.1
5 arthritis 10.0
6 urticaria 10.0
7 dermatitis 10.0
8 blood group, i system 9.9
9 granulomatous dermatitis 9.9
10 systemic lupus erythematosus 9.9
11 dermatitis herpetiformis 9.9
12 marshall syndrome 9.9
13 vasculitis 9.9
14 rheumatoid arthritis 9.9
15 lupus erythematosus 9.9
16 dermatitis herpetiformis, familial 9.9
17 light and heavy chain deposition disease 9.9
18 alpha-1-antitrypsin deficiency 9.9
19 lymphoma 9.9
20 nephrotic syndrome 9.9
21 allergic hypersensitivity disease 9.9
22 cutaneous mastocytosis 9.9
23 plasmacytoma 9.9
24 cutis laxa, autosomal dominant 1 9.7 ELN FBLN5
25 mid-dermal elastolysis 9.7 ELN FBLN5
26 supravalvular aortic stenosis 9.7 ELN FBLN5
27 pelvic organ prolapse 9.7 ELN FBLN5
28 pneumothorax 9.6 ELN FBLN5
29 aortic aneurysm 9.5 ELN FBLN5
30 connective tissue disease 9.4 ELN FBLN5

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to Acquired Cutis Laxa

Symptoms & Phenotypes for Acquired Cutis Laxa

Drugs & Therapeutics for Acquired Cutis Laxa

Search Clinical Trials , NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

Anatomical Context for Acquired Cutis Laxa

MalaCards organs/tissues related to Acquired Cutis Laxa:

38
Skin, Neutrophil, T Cells

Publications for Acquired Cutis Laxa

Articles related to Acquired Cutis Laxa:

(show top 50) (show all 56)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
Relapsing bullous amyloidosis of the oral mucosa and acquired cutis laxa in a patient with multiple myeloma: a rare triple association. ( 28247530 )
2017
3
Multiple myeloma presenting with acquired cutis laxa and primary systemic amyloidosis. ( 29311044 )
2017
4
RESULTS OF MINIMAL INVASIVE TREATMENT IN LOCALIZED ACQUIRED CUTIS LAXA TYPE 1 AND TYPE 2 - CASE REPORT AND DISCUSSION. ( 28726647 )
2017
5
Generalized acquired cutis laxa type 1: a case report and brief review of literature. ( 27136630 )
2016
6
Generalized acquired cutis laxa with papular lesions. ( 25516168 )
2015
7
Acquired cutis laxa associated with cutaneous mastocytosis. ( 26436968 )
2015
8
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. ( 25497952 )
2015
9
Acquired cutis laxa: diagnostic and therapeutic considerations. ( 25027942 )
2014
10
Acquired cutis laxa of face with multiple myeloma. ( 25201849 )
2014
11
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. ( 24676529 )
2014
12
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
13
Emphysema associated with acquired cutis laxa. ( 23506607 )
2013
14
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. ( 24346874 )
2013
15
Acral localized acquired cutis laxa. ( 23675943 )
2013
16
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. ( 23694828 )
2013
17
Generalized acquired cutis laxa treated with facial plastic surgery. ( 21252033 )
2011
18
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. ( 20849517 )
2011
19
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. ( 21810393 )
2011
20
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. ( 21422340 )
2011
21
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. ( 21283929 )
2011
22
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. ( 20199420 )
2010
23
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. ( 20574607 )
2010
24
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. ( 21173333 )
2010
25
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. ( 20585600 )
2010
26
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. ( 19467378 )
2009
27
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. ( 19438565 )
2009
28
Acquired cutis laxa in childhood Sweet's syndrome. ( 19706111 )
2009
29
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
30
Elastic tissue damage in cephalic acquired cutis laxa. ( 18095996 )
2008
31
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. ( 18191696 )
2008
32
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. ( 16374472 )
2006
33
[Localized acquired cutis laxa associated with trachyonychia]. ( 16476396 )
2005
34
Acral localized acquired cutis laxa associated with rheumatoid arthritis. ( 11756959 )
2002
35
Acquired cutis laxa associated with multiple myeloma. ( 11868975 )
2002
36
Post febrile acquired cutis laxa. ( 20885052 )
1999
37
Increased fibroblast elastase activity in acquired cutis laxa. ( 10449932 )
1999
38
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. ( 9372355 )
1997
39
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. ( 8776377 )
1996
40
Acquired cutis laxa associated with a plasma cell dyscrasia. ( 8902101 )
1996
41
Acrolocalized acquired cutis laxa. ( 8736350 )
1996
42
Acquired cutis laxa associated with chronic urticaria. ( 7593805 )
1995
43
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency. ( 7574835 )
1995
44
Abnormalities of fibrillin in acquired cutis laxa. ( 8188885 )
1994
45
Acquired cutis laxa with dermatitis herpetiformis and sarcoidosis. ( 8408824 )
1993
46
Acquired cutis laxa confined to the face. ( 2061455 )
1991
47
Acral localized acquired cutis laxa. ( 2745770 )
1989
48
Localized acquired cutis laxa in one of identical twins. ( 2767840 )
1989
49
Acquired cutis laxa concomitant with nephrotic syndrome. ( 3307640 )
1987
50
Acquired cutis laxa: case report and review of disorders of elastolysis. ( 4011506 )
1985

Variations for Acquired Cutis Laxa

Expression for Acquired Cutis Laxa

Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for Acquired Cutis Laxa

Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 ELN FBLN5
2
Show member pathways
10.49 ELN FBLN5

GO Terms for Acquired Cutis Laxa

Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.16 ELN FBLN5
2 proteinaceous extracellular matrix GO:0005578 8.96 ELN FBLN5
3 elastic fiber GO:0071953 8.62 ELN FBLN5

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.62 ELN FBLN5

Sources for Acquired Cutis Laxa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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