MCID: ACQ027
MIFTS: 27

Acquired Cutis Laxa malady

Categories: Genetic diseases, Skin diseases, Rare diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Fetal diseases, Mental diseases, Bone diseases, Gastrointestinal diseases, Nephrological diseases, Cardiovascular diseases

Aliases & Classifications for Acquired Cutis Laxa

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Sources:
52Orphanet, 66UMLS, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 52
Cutis Laxa, Acquired Type 66
 
Cutis Laxa Acquisita 52

Characteristics:

Orphanet epidemiological data:

52
cutis laxa acquisita:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

Orphanet52 ORPHA228285
UMLS via Orphanet67 C0406549

Summaries for Acquired Cutis Laxa

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MalaCards based summary: Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and myeloma. An important gene associated with Acquired Cutis Laxa is FBLN5 (Fibulin 5), and among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Acquired Cutis Laxa

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Diseases in the Cutis Laxa family:

Cutis Laxa, Ad Cutis Laxa, Autosomal Recessive, Type Iiia
Cutis Laxa, Autosomal Dominant 3 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iia Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Iib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Recessive, Type Ic
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Cutis Laxa, Autosomal Dominant Cutis Laxa, Autosomal Recessive Type 1
Aldh18a1-Related Cutis Laxa Eln-Related Cutis Laxa
Pycr1-Related Cutis Laxa acquired cutis laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1cutis laxa10.8
2myeloma10.5
3multiple myeloma10.5
4amyloidosis10.2
5arthritis10.1
6urticaria10.1
7dermatitis10.1
8heavy chain deposition disease10.1
9rheumatoid arthritis9.9
10marshall syndrome9.9
11systemic lupus erythematosus9.9
12lymphoma9.9
13nephrotic syndrome9.9
14cutaneous mastocytosis9.9
15plasmacytoma9.9
16granulomatous dermatitis9.9
17dermatitis herpetiformis9.9
18vasculitis9.9
19lupus erythematosus9.9
20mastocytosis9.9
21esophagitis, eosinophilic, 19.7ELN, FBLN5
22late-onset focal dermal elastosis9.7ELN, FBLN5
23flna-related periventricular nodular heterotopia9.7ELN, FBLN5
24spastic paraplegia 19.6ELN, FBLN5
25acquired pseudoxanthoma elasticum9.6ELN, FBLN5
26cutis laxa, ad9.5ELN, FBLN5
27childhood spinal cord tumor9.5ELN, FBLN5
28lipid metabolism disorder9.4ELN, FBLN5
29anoxia9.2ELN, FBLN5

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to acquired cutis laxa

Symptoms for Acquired Cutis Laxa

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Drugs & Therapeutics for Acquired Cutis Laxa

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

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Anatomical Context for Acquired Cutis Laxa

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MalaCards organs/tissues related to Acquired Cutis Laxa:

34
Skin, Neutrophil, T cells

Animal Models for Acquired Cutis Laxa or affiliated genes

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Publications for Acquired Cutis Laxa

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Articles related to Acquired Cutis Laxa:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Generalized acquired cutis laxa type 1: a case report and brief review of literature. (27136630)
2016
2
Acquired cutis laxa associated with cutaneous mastocytosis. (26436968)
2015
3
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. (25497952)
2015
4
Generalized acquired cutis laxa with papular lesions. (25516168)
2015
5
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. (24676529)
2014
6
Acquired cutis laxa: diagnostic and therapeutic considerations. (25027942)
2014
7
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. (25133950)
2014
8
Acquired cutis laxa of face with multiple myeloma. (25201849)
2014
9
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. (24346874)
2013
10
Emphysema associated with acquired cutis laxa. (23506607)
2013
11
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. (23694828)
2013
12
Acral localized acquired cutis laxa. (23675943)
2013
13
Generalized acquired cutis laxa treated with facial plastic surgery. (21252033)
2011
14
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. (21810393)
2011
15
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. (20849517)
2011
16
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. (21283929)
2011
17
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. (21422340)
2011
18
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. (20574607)
2010
19
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. (20199420)
2010
20
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. (20585600)
2010
21
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. (21173333)
2010
22
Acquired cutis laxa in childhood Sweet's syndrome. (19706111)
2009
23
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. (19467378)
2009
24
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. (19438565)
2009
25
Acquired cutis laxa associated with heavy chain deposition disease. (19119136)
2008
26
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. (18191696)
2008
27
Elastic tissue damage in cephalic acquired cutis laxa. (18095996)
2008
28
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. (16374472)
2006
29
Localized acquired cutis laxa associated with trachyonychia]. (16476396)
2005
30
Acquired cutis laxa associated with multiple myeloma. (11868975)
2002
31
Acral localized acquired cutis laxa associated with rheumatoid arthritis. (11756959)
2002
32
Increased fibroblast elastase activity in acquired cutis laxa. (10449932)
1999
33
Post febrile acquired cutis laxa. (20885052)
1999
34
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. (9372355)
1997
35
Acquired cutis laxa associated with a plasma cell dyscrasia. (8902101)
1996
36
Acrolocalized acquired cutis laxa. (8736350)
1996
37
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency. (7574835)
1995
38
Acquired cutis laxa associated with chronic urticaria. (7593805)
1995
39
Abnormalities of fibrillin in acquired cutis laxa. (8188885)
1994
40
Acquired cutis laxa confined to the face. (2061455)
1991
41
Localized acquired cutis laxa in one of identical twins. (2767840)
1989
42
Acral localized acquired cutis laxa. (2745770)
1989
43
Acquired cutis laxa concomitant with nephrotic syndrome. (3307640)
1987
44
Acquired cutis laxa: case report and review of disorders of elastolysis. (4011506)
1985
45
Acquired cutis laxa and multiple myeloma. (6696851)
1984
46
Multiple myeloma associated with acquired cutis laxa. (7408543)
1980
47
Acquired cutis laxa (generalized elastolysis): light and electron microscopic studies. (92145)
1979
48
Acquired cutis laxa associated with multiple myeloma. (942220)
1976
49
Acquired cutis laxa. Primary generalized elastolysis. (5555855)
1971
50
Tracheobronchiomegaly and acquired cutis laxa in a child. Physiologic and immunologic studies. (4192682)
1969

Variations for Acquired Cutis Laxa

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Expression for genes affiliated with Acquired Cutis Laxa

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Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for genes affiliated with Acquired Cutis Laxa

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Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1ELN, FBLN5
2
Show member pathways
9.1ELN, FBLN5

GO Terms for genes affiliated with Acquired Cutis Laxa

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Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1elastic fiberGO:00719539.7ELN, FBLN5
2proteinaceous extracellular matrixGO:00055789.1ELN, FBLN5

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1ELN, FBLN5

Sources for Acquired Cutis Laxa

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet