MCID: ACQ027
MIFTS: 41

Acquired Cutis Laxa malady

Genetic diseases, Skin diseases, Rare diseases, Neuronal diseases, Eye diseases, Bone diseases, Metabolic diseases, Fetal diseases categories
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Summaries for Acquired Cutis Laxa

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MalaCards based summary: Acquired Cutis Laxa, also known as cutis laxa acquisita, is related to cutis laxa and myeloma. An important gene associated with Acquired Cutis Laxa is FBLN5 (fibulin 5), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Elastic fibre formation. The compounds orcein and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and neutrophil, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Acquired Cutis Laxa

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Acquired Cutis Laxa, Aliases & Descriptions:

Name: Acquired Cutis Laxa 48 62
 
Cutis Laxa Acquisita 48


Classifications:

Orphanet: 48 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

48
acquired cutis laxa:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

UMLS via Orphanet63 C0406549

Related Diseases for Acquired Cutis Laxa

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Diseases in the Atp6v0a2-Related Cutis Laxa family:

Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Eln-Related Cutis Laxa
Pycr1-Related Cutis Laxa Aldh18a1-Related Cutis Laxa
Cutis Laxa, Ad acquired cutis laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1cutis laxa31.0ELN, ELANE, FBLN5, FBN1
2myeloma10.8
3multiple myeloma10.8
4amyloidosis10.5
5dermatitis10.4
6urticaria10.4
7fbln5-related cutis laxa10.4FBLN5
8aortic disease10.4FBN1
9aortic aneurysm10.4FBN1
10homocysteinemia10.4ELN
11costello syndrome10.4ELN
12cutaneous mastocytosis10.3
13mastocytosis10.3
14alpha 1-antitrypsin deficiency10.3
15arthritis10.3
16rheumatoid arthritis10.3
17systemic lupus erythematosus10.3
18granulomatous dermatitis10.3
19dermatitis herpetiformis10.3
20lupus erythematosus10.3
21nephrotic syndrome10.3
22plasmacytoma10.3
23sarcoidosis10.3
24vasculitis10.3
25marshall syndrome10.3
26heavy chain deposition disease10.3
27emphysema due to aat deficiency10.2ELANE
28thoracic aortic aneurysm10.1FBN1, ELN
29exfoliation syndrome10.1ELN, FBN1
30pseudoxanthoma elasticum10.1ELN, FBN1
31telangiectasis10.1ELN, FBN1
32marfan syndrome10.1ELN, FBN1
33williams syndrome10.1FBN1, ELN
34hypertrophic scars10.1ELN, FBN1
35ehlers-danlos syndrome10.1FBN1, ELN
36hyperhomocysteinemia10.1FBN1, ELN
37cerebral aneurysms10.0ELANE, ELN
38pulmonary emphysema10.0ELANE, ELN
39adult respiratory distress syndrome10.0ELN, ELANE
40intracranial aneurysm10.0ELANE, ELN
41congenital heart disease10.0FBN1, ELN
42wegener's granulomatosis9.9ELN, ELANE
43pulmonary hypertension9.9ELANE, ELN
44mental retardation9.9ELN, FBN1
45supravalvular aortic stenosis9.9FBN1, ELN, FBLN5
46connective tissue disease9.9ELN, FBLN5, FBN1
47pulmonary fibrosis9.9ELANE, ELN
48chronic obstructive pulmonary disease9.9ELANE, ELN
49cork-handlers' disease9.9ELANE, ELN
50vascular disease9.8ELANE, ELN

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to acquired cutis laxa

Symptoms for Acquired Cutis Laxa

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Drugs & Therapeutics for Acquired Cutis Laxa

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Drug clinical trials:

Search ClinicalTrials for Acquired Cutis Laxa

Search NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

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Anatomical Context for Acquired Cutis Laxa

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MalaCards organs/tissues related to Acquired Cutis Laxa:

32
Skin, T cells, Neutrophil

Animal Models for Acquired Cutis Laxa or affiliated genes

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MGI Mouse Phenotypes related to Acquired Cutis Laxa:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8ELN, FBLN5, FBN1
2MP:00053888.5FBN1, FBLN5, ELN
3MP:00053767.9ELN, ELANE, FBLN5, FBN1

Publications for Acquired Cutis Laxa

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Articles related to Acquired Cutis Laxa:

(show all 47)
idTitleAuthorsYear
1
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. (25133950)
2014
2
Acquired cutis laxa of face with multiple myeloma. (25201849)
2014
3
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. (24676529)
2014
4
Acquired cutis laxa: diagnostic and therapeutic considerations. (25027942)
2014
5
Acral localized acquired cutis laxa. (23675943)
2013
6
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. (24346874)
2013
7
Emphysema associated with acquired cutis laxa. (23506607)
2013
8
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. (23694828)
2013
9
Generalized acquired cutis laxa treated with facial plastic surgery. (21252033)
2011
10
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. (21810393)
2011
11
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. (20849517)
2011
12
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. (21283929)
2011
13
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. (21422340)
2011
14
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. (20574607)
2010
15
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. (20585600)
2010
16
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. (20199420)
2010
17
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. (21173333)
2010
18
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. (19467378)
2009
19
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. (19438565)
2009
20
Acquired cutis laxa in childhood Sweet's syndrome. (19706111)
2009
21
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. (18191696)
2008
22
Elastic tissue damage in cephalic acquired cutis laxa. (18095996)
2008
23
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. (16374472)
2006
24
Localized acquired cutis laxa associated with trachyonychia]. (16476396)
2005
25
Acral localized acquired cutis laxa associated with rheumatoid arthritis. (11756959)
2002
26
Acquired cutis laxa associated with multiple myeloma. (11868975)
2002
27
Increased fibroblast elastase activity in acquired cutis laxa. (10449932)
1999
28
Post febrile acquired cutis laxa. (20885052)
1999
29
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. (9372355)
1997
30
Acquired cutis laxa associated with a plasma cell dyscrasia. (8902101)
1996
31
Acrolocalized acquired cutis laxa. (8736350)
1996
32
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. (8776377)
1996
33
Acquired cutis laxa associated with chronic urticaria. (7593805)
1995
34
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency. (7574835)
1995
35
Abnormalities of fibrillin in acquired cutis laxa. (8188885)
1994
36
Acquired cutis laxa with dermatitis herpetiformis and sarcoidosis. (8408824)
1993
37
Acquired cutis laxa confined to the face. (2061455)
1991
38
Localized acquired cutis laxa in one of identical twins. (2767840)
1989
39
Acral localized acquired cutis laxa. (2745770)
1989
40
Acquired cutis laxa concomitant with nephrotic syndrome. (3307640)
1987
41
Acquired cutis laxa: case report and review of disorders of elastolysis. (4011506)
1985
42
Acquired cutis laxa and multiple myeloma. (6696851)
1984
43
Multiple myeloma associated with acquired cutis laxa. (7408543)
1980
44
Acquired cutis laxa (generalized elastolysis): light and electron microscopic studies. (92145)
1979
45
Acquired cutis laxa associated with multiple myeloma. (942220)
1976
46
Acquired cutis laxa. Primary generalized elastolysis. (5555855)
1971
47
Tracheobronchiomegaly and acquired cutis laxa in a child. Physiologic and immunologic studies. (4192682)
1969

Variations for Acquired Cutis Laxa

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Expression for genes affiliated with Acquired Cutis Laxa

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Expression patterns in normal tissues for genes affiliated with Acquired Cutis Laxa

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Pathways for genes affiliated with Acquired Cutis Laxa

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Pathways related to Acquired Cutis Laxa according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ELN, ELANE
2
Show member pathways
8.8ELN, FBLN5, FBN1
3
Show member pathways
8.0ELN, ELANE, FBLN5, FBN1

Compounds for genes affiliated with Acquired Cutis Laxa

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Compounds related to Acquired Cutis Laxa according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1orcein449.7FBN1, ELN
2cacl2449.7ELN, FBN1
3hydroxyproline44 24 1111.7ELN, FBN1
4chondroitin sulfate44 2410.6FBN1, ELN
5amine449.6FBN1, ELN
6tgf beta1449.5FBN1, ELN
7heparan sulfate44 2410.5ELN, FBN1
8isodesmosine449.4ELN, ELANE
9tannins449.4ELANE, ELN
10(4-aminophenyl)mercuric acetate449.4ELN, ELANE
11thermolysin449.4ELANE, ELN
12diisopropylfluorophosphate449.4ELN, ELANE
13alginate449.4ELN, ELANE
14dermatan sulfate449.4ELN, ELANE
15doxycycline44 1110.4ELN, ELANE
16sodium nitroprusside449.3ELANE, ELN
17hydrocortisone44 2 61 1112.3ELN, ELANE
18carbon449.2ELN, ELANE
19valine449.1ELANE, ELN
20vitamin a44 24 1111.1ELN, ELANE
21chloramphenicol44 2 50 1112.0ELANE, ELN
22ascorbic acid44 2410.0ELN, FBN1
23fibrinogen449.0ELN, ELANE
24desmosine448.9ELN, ELANE, FBN1
25sodium dodecylsulfate448.9ELN, ELANE, FBN1
26hyaluronic acid44 249.9ELN, ELANE, FBN1
27vitamin d448.9FBN1, ELANE, ELN
28heparin44 28 24 1111.9FBN1, ELANE, ELN
29glutamate448.8ELN, ELANE, FBN1
30estrogen448.8ELN, ELANE, FBN1
31retinoic acid44 249.8ELN, ELANE, FBN1
32cysteine448.7FBN1, ELANE, ELN
33serine448.4ELN, ELANE, FBN1

GO Terms for genes affiliated with Acquired Cutis Laxa

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Cellular components related to Acquired Cutis Laxa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.4FBLN5, FBN1
2elastic fiberGO:0719539.3FBLN5, ELN
3proteinaceous extracellular matrixGO:0055788.7FBN1, FBLN5, ELN
4extracellular regionGO:0055767.7FBN1, FBLN5, ELANE, ELN

Biological processes related to Acquired Cutis Laxa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226178.5ELN, ELANE, FBN1
2extracellular matrix organizationGO:0301987.7ELN, ELANE, FBLN5, FBN1

Molecular functions related to Acquired Cutis Laxa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.3ELN, FBN1

Products for genes affiliated with Acquired Cutis Laxa

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Sources for Acquired Cutis Laxa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet