MCID: ACQ022
MIFTS: 46

Acquired Generalized Lipodystrophy malady

Genetic diseases, Skin diseases, Endocrine diseases, Rare diseases, Fetal diseases, Neuronal diseases, Muscle diseases categories
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Summaries for Acquired Generalized Lipodystrophy

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Wikipedia:65 Acquired generalized lipodystrophy (also known as \"Lawrence syndrome,\" and \"Lawrence?Seip syndrome\")... more...

MalaCards based summary: Acquired Generalized Lipodystrophy, also known as lawrence-seip syndrome, is related to lipodystrophy and acanthosis nigricans. An important gene associated with Acquired Generalized Lipodystrophy is RETN (resistin), and among its related pathways are Selected targets of C EBPalpha and Selected targets of C EBPbeta. The compounds atazanavir and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Acquired Generalized Lipodystrophy

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet, 26ICD10 via Orphanet
See all sources

Acquired Generalized Lipodystrophy, Aliases & Descriptions:

Name: Acquired Generalized Lipodystrophy 48
Lawrence-Seip Syndrome 48 62
 
Lawrence Syndrome 48 62
Acquired Lipoatrophic Diabetes 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
lawrence-seip syndrome:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

UMLS via Orphanet63 C0271693
ICD10 via Orphanet26 E88.1

Related Diseases for Acquired Generalized Lipodystrophy

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Diseases in the Congenital Generalized Lipodystrophy Type 2 family:

Congenital Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 1
Congenital Generalized Lipodystrophy Type 4 Congenital Generalized Lipodystrophy Type 3
acquired generalized lipodystrophy

Diseases related to Acquired Generalized Lipodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1lipodystrophy30.5INS, RETN, LEP, ADIPOQ
2acanthosis nigricans30.2LEP, ADIPOQ, INS
3type 2 diabetes mellitus29.6RETN, INS, LEP, ADIPOQ
4insulin resistance29.6RETN, ADIPOQ, LEP, INS
5diabetes mellitus29.6INS, LEP, RETN, ADIPOQ
6rabson-mendenhall syndrome10.4INS
7lipoatrophic diabetes10.3
8autoimmune hepatitis10.2
9hepatitis10.2
10pulmonary tuberculosis10.2
11panniculitis10.2
12tuberculosis10.2
13cerebellar degeneration10.2
14prediabetes syndrome10.1ADIPOQ, INS
15idiopathic edema10.1INS, ADIPOQ
16familial partial lipodystrophy10.0INS, LEP
17familial combined hyperlipidemia10.0ADIPOQ, INS
18fetal macrosomia10.0LEP, INS
19anovulation10.0LEP, INS
20bulimia nervosa10.0LEP, RETN
21amenorrhea10.0LEP, INS
22obstructive sleep apnea10.0ADIPOQ, LEP
23morbid obesity10.0INS, LEP
24hypopituitarism10.0LEP, INS
25eating disorder10.0RETN, LEP
26liver cirrhosis10.0RETN, ADIPOQ
27polycystic ovary syndrome10.0INS, LEP
28diabetic nephropathy9.9INS, ADIPOQ
29hypercholesterolemia9.9INS, RETN, ADIPOQ
30primary hyperoxaluria9.9LEP, INS
31vascular disease9.9ADIPOQ, RETN, INS
32non-suppurative otitis media9.9ADIPOQ, LEP
33short stature9.9INS, LEP
34coronary artery anomaly9.9INS, RETN, ADIPOQ
35hyperinsulinism9.8RETN, LEP, INS
36fatty liver disease9.8INS, RETN, LEP
37proteinuria9.8ADIPOQ, INS
38hyperthyroidism9.8INS, LEP, RETN
39hypothyroidism9.8LEP, INS, RETN
40congenital heart disease9.8LEP, INS, RETN
41infertility9.8LEP, RETN, INS
42type 1 diabetes mellitus9.8LEP, INS, RETN
43congenital generalized lipodystrophy type 29.8LEP, INS, ADIPOQ
44hypertension9.8RETN, LEP, INS
45growth hormone deficiency9.8INS, ADIPOQ, LEP
46anorexia nervosa9.8LEP, ADIPOQ, RETN
47uremia9.8ADIPOQ, LEP, RETN
48cushing's syndrome9.8LEP, ADIPOQ, RETN
49hypogonadism9.8LEP, ADIPOQ, INS
50hypertriglyceridemia9.8INS, ADIPOQ, LEP

Graphical network of the top 20 diseases related to Acquired Generalized Lipodystrophy:



Diseases related to acquired generalized lipodystrophy

Symptoms for Acquired Generalized Lipodystrophy

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Drugs & Therapeutics for Acquired Generalized Lipodystrophy

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Drug clinical trials:

Search ClinicalTrials for Acquired Generalized Lipodystrophy

Search NIH Clinical Center for Acquired Generalized Lipodystrophy

Genetic Tests for Acquired Generalized Lipodystrophy

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Anatomical Context for Acquired Generalized Lipodystrophy

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MalaCards organs/tissues related to Acquired Generalized Lipodystrophy:

32
Skin, Bone

Animal Models for Acquired Generalized Lipodystrophy or affiliated genes

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MGI Mouse Phenotypes related to Acquired Generalized Lipodystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5ADIPOQ, LEP, INS
2MP:00053678.4ADIPOQ, LEP, INS
3MP:00053698.2INS, LEP, ADIPOQ
4MP:00053758.1RETN, ADIPOQ, LEP, INS
5MP:00053708.1INS, LEP, ADIPOQ, RETN
6MP:00053768.0INS, LEP, ADIPOQ, RETN

Publications for Acquired Generalized Lipodystrophy

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Articles related to Acquired Generalized Lipodystrophy:

(show all 12)
idTitleAuthorsYear
1
Response to comments on "Late-onset acquired generalized lipodystrophy with muscle involvement". (23962584)
2013
2
Comment on: late-onset acquired generalized lipodystrophy with muscle involvement. (23985087)
2013
3
Acquired generalized lipodystrophy associated with peripheral TA cell lymphoma with cutaneous infiltration. (24168394)
2013
4
Late-onset acquired generalized lipodystrophy with muscle involvement. (22188950)
2012
5
Acquired generalized lipodystrophy associated with autoimmune hepatitis and low serum C4 level. (21274335)
2010
6
Case report: unicameral bone cysts in a young patient with acquired generalized lipodystrophy. (19924491)
2010
7
Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessment. (20616664)
2010
8
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. (17940115)
2008
9
Acquired generalized lipodystrophy (panniculitis variety) triggered by pulmonary tuberculosis. (17651183)
2007
10
A case of acquired generalized lipodystrophy with cerebellar degeneration and type 2 diabetes mellitus. (17491704)
2004
11
Dysregulation of growth hormone in acquired generalized lipodystrophy. (15573230)
2004
12
Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. (12640189)
2003

Variations for Acquired Generalized Lipodystrophy

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Expression for genes affiliated with Acquired Generalized Lipodystrophy

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Expression patterns in normal tissues for genes affiliated with Acquired Generalized Lipodystrophy

Search GEO for disease gene expression data for Acquired Generalized Lipodystrophy.

Pathways for genes affiliated with Acquired Generalized Lipodystrophy

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Pathways related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3RETN, ADIPOQ
29.3RETN, ADIPOQ
39.3ADIPOQ, INS
4
Show member pathways
9.3ADIPOQ, INS
59.1LEP, INS
6
Show member pathways
9.1LEP, INS
7
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.1LEP, INS
89.1INS, LEP
9
Show member pathways
9.1INS, LEP
10
Show member pathways
9.0ADIPOQ, LEP
119.0LEP, ADIPOQ
129.0ADIPOQ, LEP
13
Show member pathways
8.5INS, LEP, ADIPOQ
14
Show member pathways
8.5ADIPOQ, LEP, INS
158.0RETN, ADIPOQ, LEP, INS
16
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.0RETN, ADIPOQ, LEP, INS

Compounds for genes affiliated with Acquired Generalized Lipodystrophy

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Compounds related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1atazanavir44 50 1111.5INS, ADIPOQ
2olmesartan44 28 1111.4INS, ADIPOQ
3exenatide44 1110.4INS, LEP
4glimepiride44 50 1111.2INS, ADIPOQ, RETN
52-arachidonoylglycerol44 2810.2ADIPOQ, LEP
6pramlintide44 1110.1INS, LEP
7beta-hydroxybutyrate449.1LEP, INS
8rimonabant44 28 1111.1ADIPOQ, LEP
9sibutramine44 119.9INS, LEP, ADIPOQ
10stavudine44 119.9LEP, ADIPOQ
11acipimox44 289.9ADIPOQ, LEP, INS
12telmisartan44 28 1110.9ADIPOQ, LEP, INS
13orlistat44 61 1110.9ADIPOQ, LEP, INS
14aicar44 24 1110.9INS, LEP, ADIPOQ
1511beta-hydroxysteroid448.9LEP, ADIPOQ, RETN
16dehydroepiandrosterone sulfate448.9ADIPOQ, LEP, INS
17glibenclamide44 28 50 6111.9ADIPOQ, LEP, INS
18olanzapine44 50 28 24 1112.9INS, LEP, ADIPOQ
19triacylglycerol448.9ADIPOQ, LEP, INS
20androstenedione44 249.9ADIPOQ, LEP, INS
21p003448.8RETN, ADIPOQ, LEP
22p002448.8RETN, ADIPOQ, LEP
23troglitazone44 28 61 1111.8INS, LEP, ADIPOQ
24carbohydrates448.8ADIPOQ, LEP, INS
25glycerol44 24 1110.7ADIPOQ, LEP, INS
26vitamin a44 24 1110.7RETN, ADIPOQ, LEP
27nash448.4RETN, ADIPOQ, LEP, INS
28thiazolidinedione448.4INS, LEP, ADIPOQ, RETN
298-isoprostane448.4INS, LEP, ADIPOQ, RETN
30fenofibrate44 50 1110.4INS, LEP, ADIPOQ, RETN
31c-peptide448.4INS, LEP, ADIPOQ, RETN
32metformin44 50 1110.4INS, LEP, ADIPOQ, RETN
33dhea448.4INS, LEP, ADIPOQ, RETN
34pioglitazone28 44 50 1111.4INS, LEP, ADIPOQ, RETN
35uric acid44 249.4INS, LEP, ADIPOQ, RETN
36rosiglitazone28 44 50 24 1112.4RETN, ADIPOQ, LEP, INS
37thyroxine44 249.4RETN, ADIPOQ, LEP, INS
38fibrinogen448.4INS, LEP, ADIPOQ, RETN
39norepinephrine44 24 1110.4RETN, ADIPOQ, LEP, INS
40ly294002448.4INS, LEP, ADIPOQ, RETN
41fatty acid448.4INS, LEP, ADIPOQ, RETN
42creatinine448.4INS, LEP, ADIPOQ, RETN
43testosterone44 61 24 1111.3INS, LEP, ADIPOQ, RETN
44cholesterol44 28 24 1111.3INS, LEP, ADIPOQ, RETN
45dexamethasone44 50 28 1111.3INS, LEP, ADIPOQ, RETN
46phosphatidylinositol448.3INS, LEP, ADIPOQ, RETN
47glutamate448.3RETN, ADIPOQ, LEP, INS
48estrogen448.2INS, LEP, ADIPOQ, RETN
49glucose448.2INS, LEP, ADIPOQ, RETN
50lipid447.7RETN, ADIPOQ, LEP, INS

GO Terms for genes affiliated with Acquired Generalized Lipodystrophy

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Cellular components related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ADIPOQ, LEP, INS
2extracellular spaceGO:0056157.7RETN, ADIPOQ, LEP, INS

Biological processes related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:20002529.7RETN, INS
2negative regulation of gluconeogenesisGO:0457219.6INS, ADIPOQ
3positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, INS
4positive regulation of glucose importGO:0463269.5ADIPOQ, INS
5positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4ADIPOQ, INS
6positive regulation of insulin receptor signaling pathwayGO:0466289.4INS, LEP
7response to insulinGO:0328689.3RETN, LEP
8positive regulation of MAPK cascadeGO:0434109.2LEP, INS
9glucose homeostasisGO:0425939.2INS, ADIPOQ
10circadian rhythmGO:0076239.2LEP, ADIPOQ
11regulation of insulin secretionGO:0507969.1INS, LEP
12response to hypoxiaGO:0016669.0ADIPOQ, LEP
13energy reserve metabolic processGO:0061128.8LEP, INS
14glucose metabolic processGO:0060068.8ADIPOQ, LEP, INS

Molecular functions related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.0RETN, ADIPOQ, LEP, INS

Products for genes affiliated with Acquired Generalized Lipodystrophy

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Sources for Acquired Generalized Lipodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet