MCID: ACQ022
MIFTS: 40

Acquired Generalized Lipodystrophy malady

Genetic diseases, Skin diseases, Endocrine diseases, Rare diseases, Neuronal diseases, Muscle diseases categories

Aliases & Classifications for Acquired Generalized Lipodystrophy

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet, 26ICD10 via Orphanet
See all sources

Acquired Generalized Lipodystrophy, Aliases & Descriptions:

Name: Acquired Generalized Lipodystrophy 47
Familial Generalized Lipodystrophy 60
Acquired Lipoatrophic Diabetes 47
 
Lawrence-Seip Syndrome 47
Lawrence Syndrome 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
acquired generalized lipodystrophy:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 79086
UMLS via Orphanet61 C0271693
ICD10 via Orphanet26 E88.1

Summaries for Acquired Generalized Lipodystrophy

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Wikipedia:63 Acquired generalized lipodystrophy (also known as \"Lawrence syndrome,\" and \"Lawrence?Seip syndrome\")... more...

MalaCards based summary: Acquired Generalized Lipodystrophy, also known as familial generalized lipodystrophy, is related to lipodystrophy and acanthosis nigricans. An important gene associated with Acquired Generalized Lipodystrophy is RETN (resistin), and among its related pathways are Selected targets of C EBPalpha and Selected targets of C EBPbeta. The compounds atazanavir and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Related Diseases for Acquired Generalized Lipodystrophy

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Diseases in the Acquired Generalized Lipodystrophy family:

Lipodystrophy, Congenital Generalized, Type 3 Lipodystrophy, Congenital Generalized, Type 1
Lipodystrophy, Congenital Generalized, Type 2 Lipodystrophy, Congenital Generalized, Type 4
Congenital Generalized Lipodystrophy

Diseases related to Acquired Generalized Lipodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1lipodystrophy30.5INS, RETN, LEP, ADIPOQ
2acanthosis nigricans30.2LEP, ADIPOQ, INS
3rabson-mendenhall syndrome10.4INS
4autoimmune hepatitis10.2
5hepatitis10.2
6pulmonary tuberculosis10.2
7panniculitis10.2
8tuberculosis10.2
9cerebellar degeneration10.2
10prediabetes syndrome10.1ADIPOQ, INS
11idiopathic edema10.1INS, ADIPOQ
12liver disease10.1INS, LEP
13familial partial lipodystrophy10.0INS, LEP
14fetal macrosomia10.0LEP, INS
15hyperlipidemia, familial combined10.0ADIPOQ, INS
16anovulation10.0LEP, INS
17bulimia nervosa10.0LEP, RETN
18obstructive sleep apnea10.0ADIPOQ, LEP
19amenorrhea10.0LEP, INS
20morbid obesity10.0INS, LEP
21liver cirrhosis10.0RETN, ADIPOQ
22hypopituitarism10.0LEP, INS
23eating disorder10.0RETN, LEP
24polycystic ovary syndrome9.9INS, LEP
25microvascular complications of diabetes 39.9INS, ADIPOQ
26hypercholesterolemia, familial9.9INS, RETN, ADIPOQ
27vascular disease9.9ADIPOQ, RETN, INS
28primary hyperoxaluria9.9LEP, INS
29coronary artery disease9.9INS, RETN, ADIPOQ
30non-suppurative otitis media9.9ADIPOQ, LEP
31hyperinsulinism9.8RETN, LEP, INS
32fatty liver disease9.8INS, RETN, LEP
33proteinuria9.8ADIPOQ, INS
34hyperthyroidism9.8INS, LEP, RETN
35hypothyroidism9.8LEP, INS, RETN
36congenital heart disease9.8LEP, INS, RETN
37infertility9.8LEP, RETN, INS
38diabetes mellitus, insulin-dependent9.8LEP, INS, RETN
39berardinelli-seip congenital lipodystrophy9.8LEP, INS, ADIPOQ
40growth hormone deficiency9.8INS, ADIPOQ, LEP
41hypertension, essential9.8RETN, LEP, INS
42anorexia nervosa9.8LEP, ADIPOQ, RETN
43uremia9.8ADIPOQ, LEP, RETN
44cushing's syndrome9.8LEP, ADIPOQ, RETN
45nutritional deficiency disease9.8LEP, RETN, ADIPOQ
46hypogonadism9.8LEP, ADIPOQ, INS
47hypertriglyceridemia9.8INS, ADIPOQ, LEP
48preeclampsia/eclampsia 19.7LEP, ADIPOQ, RETN
49arthritis9.7RETN, ADIPOQ, LEP
50mody, type ii9.6INS, RETN, ADIPOQ, LEP

Graphical network of the top 20 diseases related to Acquired Generalized Lipodystrophy:



Diseases related to acquired generalized lipodystrophy

Symptoms for Acquired Generalized Lipodystrophy

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Drugs & Therapeutics for Acquired Generalized Lipodystrophy

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Drug clinical trials:

Search ClinicalTrials for Acquired Generalized Lipodystrophy

Search NIH Clinical Center for Acquired Generalized Lipodystrophy

Genetic Tests for Acquired Generalized Lipodystrophy

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Anatomical Context for Acquired Generalized Lipodystrophy

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MalaCards organs/tissues related to Acquired Generalized Lipodystrophy:

31
Skin, Bone

Animal Models for Acquired Generalized Lipodystrophy or affiliated genes

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MGI Mouse Phenotypes related to Acquired Generalized Lipodystrophy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5ADIPOQ, LEP, INS
2MP:00053678.4ADIPOQ, LEP, INS
3MP:00053698.2INS, LEP, ADIPOQ
4MP:00053758.1RETN, ADIPOQ, LEP, INS
5MP:00053708.1INS, LEP, ADIPOQ, RETN
6MP:00053768.0INS, LEP, ADIPOQ, RETN

Publications for Acquired Generalized Lipodystrophy

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Articles related to Acquired Generalized Lipodystrophy:

(show all 13)
idTitleAuthorsYear
1
Lymphoma in acquired generalized lipodystrophy. (25864863)
2015
2
Response to comments on "Late-onset acquired generalized lipodystrophy with muscle involvement". (23962584)
2013
3
Comment on: late-onset acquired generalized lipodystrophy with muscle involvement. (23985087)
2013
4
Acquired generalized lipodystrophy associated with peripheral TA cell lymphoma with cutaneous infiltration. (24168394)
2013
5
Late-onset acquired generalized lipodystrophy with muscle involvement. (22188950)
2012
6
Acquired generalized lipodystrophy associated with autoimmune hepatitis and low serum C4 level. (21274335)
2010
7
Case report: unicameral bone cysts in a young patient with acquired generalized lipodystrophy. (19924491)
2010
8
Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessment. (20616664)
2010
9
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. (17940115)
2008
10
Acquired generalized lipodystrophy (panniculitis variety) triggered by pulmonary tuberculosis. (17651183)
2007
11
A case of acquired generalized lipodystrophy with cerebellar degeneration and type 2 diabetes mellitus. (17491704)
2004
12
Dysregulation of growth hormone in acquired generalized lipodystrophy. (15573230)
2004
13
Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. (12640189)
2003

Variations for Acquired Generalized Lipodystrophy

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Expression for genes affiliated with Acquired Generalized Lipodystrophy

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Search GEO for disease gene expression data for Acquired Generalized Lipodystrophy.

Pathways for genes affiliated with Acquired Generalized Lipodystrophy

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Pathways related to Acquired Generalized Lipodystrophy according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ADIPOQ, INS
2
Show member pathways
9.3ADIPOQ, INS
3
Show member pathways
9.1LEP, INS
4
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.1LEP, INS
59.1INS, LEP
6
Show member pathways
9.1INS, LEP
7
Show member pathways
9.0ADIPOQ, LEP
89.0LEP, ADIPOQ
99.0ADIPOQ, LEP
10
Show member pathways
8.5INS, LEP, ADIPOQ
11
Show member pathways
8.5ADIPOQ, LEP, INS
128.0RETN, ADIPOQ, LEP, INS
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.0RETN, ADIPOQ, LEP, INS

Compounds for genes affiliated with Acquired Generalized Lipodystrophy

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Compounds related to Acquired Generalized Lipodystrophy according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1atazanavir43 49 1211.5ADIPOQ, INS
2olmesartan43 28 1211.4ADIPOQ, INS
3exenatide43 1210.4INS, LEP
4glimepiride43 49 1211.2RETN, ADIPOQ, INS
52-arachidonoylglycerol43 2810.2ADIPOQ, LEP
6pramlintide43 1210.1INS, LEP
7beta-hydroxybutyrate439.1LEP, INS
8rimonabant43 28 1211.1LEP, ADIPOQ
9sibutramine43 129.9LEP, ADIPOQ, INS
10stavudine43 129.9LEP, ADIPOQ
11acipimox43 289.9INS, ADIPOQ, LEP
12telmisartan43 28 1210.9LEP, INS, ADIPOQ
13orlistat43 59 1210.9ADIPOQ, INS, LEP
14aicar43 24 1210.9LEP, ADIPOQ, INS
1511beta-hydroxysteroid438.9RETN, ADIPOQ, LEP
16dehydroepiandrosterone sulfate438.9ADIPOQ, LEP, INS
17glibenclamide43 28 49 5911.9ADIPOQ, INS, LEP
18olanzapine43 49 28 24 1212.9LEP, INS, ADIPOQ
19triacylglycerol438.9LEP, INS, ADIPOQ
20androstenedione43 249.9INS, LEP, ADIPOQ
21p003438.8LEP, ADIPOQ, RETN
22p002438.8RETN, ADIPOQ, LEP
23troglitazone43 28 59 1211.8LEP, INS, ADIPOQ
24carbohydrates438.8INS, LEP, ADIPOQ
25glycerol43 24 1210.7LEP, ADIPOQ, INS
26vitamin a43 24 1210.7LEP, ADIPOQ, RETN
27nash438.4RETN, ADIPOQ, LEP, INS
28thiazolidinedione438.4INS, LEP, ADIPOQ, RETN
298-isoprostane438.4RETN, INS, LEP, ADIPOQ
30fenofibrate43 49 1210.4INS, LEP, RETN, ADIPOQ
31metformin43 49 1210.4RETN, LEP, INS, ADIPOQ
32c-peptide438.4RETN, ADIPOQ, LEP, INS
33dhea438.4INS, ADIPOQ, LEP, RETN
34pioglitazone28 43 49 1211.4ADIPOQ, INS, LEP, RETN
35uric acid43 249.4RETN, INS, LEP, ADIPOQ
36rosiglitazone28 43 49 24 1212.4ADIPOQ, LEP, INS, RETN
37thyroxine43 249.4RETN, ADIPOQ, LEP, INS
38fibrinogen438.4ADIPOQ, LEP, RETN, INS
39norepinephrine43 24 1210.4RETN, ADIPOQ, INS, LEP
40ly294002438.4LEP, ADIPOQ, INS, RETN
41fatty acid438.4INS, ADIPOQ, LEP, RETN
42creatinine438.4INS, LEP, RETN, ADIPOQ
43testosterone43 59 24 1211.3ADIPOQ, LEP, RETN, INS
44cholesterol43 28 24 1211.3LEP, RETN, ADIPOQ, INS
45dexamethasone43 49 28 1211.3ADIPOQ, LEP, INS, RETN
46phosphatidylinositol438.3ADIPOQ, RETN, INS, LEP
47glutamate438.3RETN, ADIPOQ, INS, LEP
48estrogen438.2RETN, INS, LEP, ADIPOQ
49glucose438.2ADIPOQ, LEP, INS, RETN
50lipid437.7ADIPOQ, LEP, INS, RETN

GO Terms for genes affiliated with Acquired Generalized Lipodystrophy

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Cellular components related to Acquired Generalized Lipodystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5ADIPOQ, LEP, INS
2extracellular spaceGO:00056157.7RETN, ADIPOQ, LEP, INS

Biological processes related to Acquired Generalized Lipodystrophy according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:020002529.7RETN, INS
2negative regulation of gluconeogenesisGO:00457219.6INS, ADIPOQ
3positive regulation of cellular protein metabolic processGO:00322709.6ADIPOQ, INS
4positive regulation of glucose importGO:00463269.5ADIPOQ, INS
5positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4ADIPOQ, INS
6positive regulation of insulin receptor signaling pathwayGO:00466289.4INS, LEP
7response to insulinGO:00328689.3RETN, LEP
8positive regulation of MAPK cascadeGO:00434109.2LEP, INS
9glucose homeostasisGO:00425939.2INS, ADIPOQ
10circadian rhythmGO:00076239.2LEP, ADIPOQ
11regulation of insulin secretionGO:00507969.1INS, LEP
12response to hypoxiaGO:00016669.0ADIPOQ, LEP
13energy reserve metabolic processGO:00061128.8LEP, INS
14glucose metabolic processGO:00060068.8ADIPOQ, LEP, INS

Molecular functions related to Acquired Generalized Lipodystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.0RETN, ADIPOQ, LEP, INS

Products for genes affiliated with Acquired Generalized Lipodystrophy

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Sources for Acquired Generalized Lipodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet