MCID: ACQ022
MIFTS: 37

Acquired Generalized Lipodystrophy malady

Skin diseases, Endocrine diseases, Genetic diseases categories

Summaries for Acquired Generalized Lipodystrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acquired generalized lipodystrophy (also known as \"Lawrence syndrome,\" and \"Lawrence–Seip... more...

MalaCards: Acquired Generalized Lipodystrophy, also known as familial partial lipodystrophy, type 2, is related to lipodystrophy and familial partial lipodystrophy. An important gene associated with Acquired Generalized Lipodystrophy is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Selected targets of C/EBPalpha and Selected targets of C/EBPbeta. The compounds norepinephrine and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for Acquired Generalized Lipodystrophy

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Skin diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
acquired generalized lipodystrophy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

acquired generalized lipodystrophy 48
familial partial lipodystrophy, type 2 60
familial generalized lipodystrophy 60
acquired lipoatrophic diabetes 48
lawrence-seip syndrome 48
lawrence syndrome 48


External Ids:

ICD10 via Orphanet26 E88.1
SNOMED-CT via Orphanet57 86907008
UMLS via Orphanet61 C0271693

Related Diseases for Acquired Generalized Lipodystrophy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Congenital Generalized Lipodystrophy Type 2 family:

Congenital Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 1
Congenital Generalized Lipodystrophy Type 4 Congenital Generalized Lipodystrophy Type 3
acquired generalized lipodystrophy

Diseases related to Acquired Generalized Lipodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1lipodystrophy30.9ADIPOQ, LEP, INS, RETN
2familial partial lipodystrophy30.8LEP, INS
3acanthosis nigricans30.4INS, LEP, ADIPOQ
4vascular disease30.3ADIPOQ, INS, RETN
5congenital generalized lipodystrophy type 230.3ADIPOQ, LEP, INS
6type 2 diabetes mellitus30.1RETN, INS, LEP, ADIPOQ
7diabetes mellitus30.1ADIPOQ, LEP, INS, RETN
8lipodystrophy, familial partial, type 210.4
9skin disease10.3
10vascular skin disease10.3
11lipoatrophic diabetes10.2
12unicameral bone cyst10.1
13pulmonary tuberculosis10.1
14congenital generalized lipodystrophy10.1
15autoimmune hepatitis10.1
16hepatitis10.1
17panniculitis10.1
18tuberculosis10.1
19berardinelli-seip congenital lipodystrophy10.1
20acute pancreatitis10.0RETN
21acute myocardial infarction10.0RETN
22osteoarthritis10.0RETN
23rabson-mendenhall syndrome10.0INS
24adenoma10.0INS
25diabetic retinopathy10.0INS
26thyrotoxicosis10.0INS
27asthma10.0ADIPOQ
28hepatitis b10.0ADIPOQ
29hyperuricemia10.0INS
30alzheimer's disease10.0INS
31myopathy10.0INS
32stomach cancer10.0ADIPOQ
33blindness10.0INS
34cystic fibrosis10.0INS
35choriocarcinoma10.0LEP
36neuropathy10.0INS
37severe pre-eclampsia10.0LEP
38prediabetes syndrome10.0ADIPOQ, INS
39arteriosclerosis10.0ADIPOQ
40myocardial infarction10.0ADIPOQ, RETN
41idiopathic edema10.0ADIPOQ, INS
42proteinuria10.0INS, ADIPOQ
43rheumatoid arthritis10.0ADIPOQ, RETN
44pancreatitis10.0INS
45familial combined hyperlipidemia10.0INS, ADIPOQ
46bulimia nervosa10.0RETN, LEP
47morbid obesity10.0INS, LEP
48amenorrhea10.0INS, LEP
49galactosemia10.0LEP, INS
50fetal macrosomia10.0INS, LEP

Graphical network of the top 20 diseases related to Acquired Generalized Lipodystrophy:



Diseases related to acquired generalized lipodystrophy

Clinical Features for Acquired Generalized Lipodystrophy

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Drugs & Therapeutics for Acquired Generalized Lipodystrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acquired Generalized Lipodystrophy

Drug clinical trials:

Search ClinicalTrials for Acquired Generalized Lipodystrophy

Search NIH Clinical Center for Acquired Generalized Lipodystrophy

Search CenterWatch for Acquired Generalized Lipodystrophy

Genetic Tests for Acquired Generalized Lipodystrophy

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Anatomical Context for Acquired Generalized Lipodystrophy

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32MalaCards
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MalaCards organs/tissues related to Acquired Generalized Lipodystrophy:

32
Skin

Animal Models for Acquired Generalized Lipodystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acquired Generalized Lipodystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.7RETN
2MP:00053708.0ADIPOQ, LEP, INS, RETN

Publications for Acquired Generalized Lipodystrophy

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Genetic Variations for Acquired Generalized Lipodystrophy

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Expression for genes affiliated with Acquired Generalized Lipodystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Generalized Lipodystrophy

Search GEO for disease gene expression data for Acquired Generalized Lipodystrophy.

Pathways for genes affiliated with Acquired Generalized Lipodystrophy

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12EMD Millipore, 52R&D Systems, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Acquired Generalized Lipodystrophy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.4RETN
2p0034410.3RETN
32-arachidonoylglycerol44 2810.6LEP, ADIPOQ
4rimonabant44 28 1111.6ADIPOQ, LEP
5stavudine44 1110.5ADIPOQ, LEP
6atazanavir44 49 1111.4ADIPOQ, INS
7topiramate44 11 2411.4ADIPOQ, LEP
8olmesartan44 28 1111.4INS, ADIPOQ
9exenatide44 1110.4INS, LEP
1011beta-hydroxysteroid449.2ADIPOQ, LEP, RETN
11pramlintide44 1110.2LEP, INS
12p002449.2RETN, LEP, ADIPOQ
13beta-hydroxybutyrate449.1INS, LEP
14ramipril44 1110.1INS, ADIPOQ
15gliclazide44 49 1111.0ADIPOQ, INS
16glimepiride44 49 1111.0ADIPOQ, INS, RETN
17vitamin a44 11 2411.0RETN, LEP, ADIPOQ
18sibutramine44 119.9ADIPOQ, LEP, INS
19acipimox44 289.9ADIPOQ, LEP, INS
20telmisartan44 28 1110.9INS, LEP, ADIPOQ
21orlistat44 59 1110.9ADIPOQ, LEP, INS
22aicar44 11 2410.9ADIPOQ, LEP, INS
23olanzapine49 44 28 11 2412.9ADIPOQ, LEP, INS
24glibenclamide44 28 49 5911.9INS, LEP, ADIPOQ
25triacylglycerol448.9ADIPOQ, LEP, INS
26androstenedione44 249.9INS, LEP, ADIPOQ
27troglitazone44 28 59 1111.8ADIPOQ, LEP, INS
28carbohydrates448.8INS, LEP, ADIPOQ
29glycerol44 11 2410.8ADIPOQ, LEP, INS
30intralipid448.7LEP, INS
31nash448.4ADIPOQ, LEP, INS, RETN
32thiazolidinedione448.4RETN, INS, LEP, ADIPOQ
338-isoprostane448.4RETN, INS, LEP, ADIPOQ
34fenofibrate44 49 1110.4ADIPOQ, LEP, INS, RETN
35metformin44 49 1110.4RETN, INS, LEP, ADIPOQ
36c-peptide448.4RETN, INS, LEP, ADIPOQ
37dhea448.4ADIPOQ, LEP, INS, RETN
38pioglitazone44 49 28 1111.4RETN, INS, LEP, ADIPOQ
39rosiglitazone44 49 28 11 2412.4RETN, INS, LEP, ADIPOQ
40thyroxine44 249.4RETN, INS, LEP, ADIPOQ
41fibrinogen448.4ADIPOQ, LEP, INS, RETN
42ly294002448.4RETN, INS, LEP, ADIPOQ
43creatinine448.4RETN, INS, LEP, ADIPOQ
44testosterone44 59 11 2411.4RETN, INS, LEP, ADIPOQ
45cholesterol44 28 11 2411.3ADIPOQ, LEP, INS, RETN
46dexamethasone44 49 28 1111.3ADIPOQ, LEP, INS, RETN
47phosphatidylinositol448.3ADIPOQ, LEP, INS, RETN
48glutamate448.3RETN, INS, LEP, ADIPOQ
49estrogen448.2ADIPOQ, LEP, INS, RETN
50lipid448.0ADIPOQ, LEP, INS, RETN

GO Terms for genes affiliated with Acquired Generalized Lipodystrophy

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16Gene Ontology
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Cellular components related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0ADIPOQ, LEP, INS, RETN
2extracellular spaceGO:0056157.7ADIPOQ, LEP, INS, RETN

Biological processes related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1circadian rhythmGO:0076239.5ADIPOQ, LEP
2response to insulin stimulusGO:0328689.4RETN, LEP
3negative regulation of gluconeogenesisGO:0457219.4INS, ADIPOQ
4positive regulation of cellular protein metabolic processGO:0322709.3ADIPOQ, INS
5positive regulation of glucose importGO:0463269.3INS, ADIPOQ
6positive regulation of insulin receptor signaling pathwayGO:0466289.3INS, LEP
7positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1ADIPOQ, INS
8positive regulation of MAPK cascadeGO:0434109.1LEP, INS
9energy reserve metabolic processGO:0061129.0INS, LEP
10regulation of insulin secretionGO:0507968.9LEP, INS
11glucose homeostasisGO:0425938.8ADIPOQ, INS
12glucose metabolic processGO:0060068.8ADIPOQ, LEP, INS

Molecular functions related to Acquired Generalized Lipodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.0ADIPOQ, LEP, INS, RETN

Products for genes affiliated with Acquired Generalized Lipodystrophy

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  • Antibodies
  • Proteins
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Sources for Acquired Generalized Lipodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet