AIDS
MCID: ACQ007
MIFTS: 62

Acquired Immunodeficiency Syndrome (AIDS) malady

Immune category

Summaries for Acquired Immunodeficiency Syndrome

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A human immunodeficiency virus infectious disease that results in reduction in the numbers of cd4-bearing helper t cells below 200 per µl of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in human immunodeficiency virus 1 or has material basis in human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. opportunistic infections are common in people with aids.

MalaCards: Acquired Immunodeficiency Syndrome, also known as AIDS, is related to burkitt's lymphoma and central nervous system lymphoma. An important gene associated with Acquired Immunodeficiency Syndrome is CXCL12 (chemokine (C-X-C motif) ligand 12). The drugs zalcitabine and didanosine and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Daily News HIV-related news stories compiled from media sources from across the US and other countries.

Wikipedia:64 Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease of... more...

Description from OMIM:47 609423

Aliases & Classifications for Acquired Immunodeficiency Syndrome

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

acquired immunodeficiency syndrome 8 10 61
aids 8 47 45 39
acquired immune deficiency 8


External Ids:

Disease Ontology8 DOID:635
OMIM47 609423
MeSH35 D000163
NCIt40 C2851

Related Diseases for Acquired Immunodeficiency Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 898)
idRelated DiseaseScoreTop Affiliating Genes
1burkitt's lymphoma30.6MS4A1, MPP1, CXCR5, BCL6
2central nervous system lymphoma30.6BCL6
3arthritis30.5CD163
4uveitis30.5CXCR5
5hepatitis c30.4CXCL12, CD9
6sepsis30.2SFTPD, CD163, CD9, CXCL12, SERPINA7
7immunodeficiency with hyper igm type 230.0CSN2, BCL6, SERPINA7, CD79B, CCL3L1, CALB1
8hepatitis b30.0CD9
9intraocular lymphoma30.0CXCR5
10non-hodgkin lymphoma30.0CXCL12, MS4A1, BCL6, ADA, TNFRSF17, CXCR5
11b-cell lymphomas30.0CXCR5, BCL6, MS4A1, CD79B
12thyroiditis30.0SERPINA7
13central nervous system lymphoma, primary30.0CXCR5, BCL6
14lymphoma, diffuse large cell30.0MS4A1, BCL6
15follicular lymphoma29.9MS4A1, CXCR5, BCL6
16aseptic meningitis29.8CD9, ADA
17asthma29.8CXCL12, SFTPD
18b-cell chronic lymphocytic leukemia29.5CXCL12, CD79B, MS4A1, BCL6
19n syndrome11.1
20kaposi's sarcoma10.8
21cytomegalovirus retinitis10.8
22micro syndrome10.7
23tuberculosis10.7
24toxoplasmosis10.6
25char syndrome10.5
26angiomatosis10.5
27cytomegalovirus infection10.5
28pneumocystosis10.5
29pyomyositis10.5
30cryptococcosis10.5
31mycobacterium kansasii10.5
32mass syndrome10.5
33bacteremia10.5
34molluscum contagiosum10.4
35progressive multifocal leukoencephalopathy10.4
36granuloma annulare10.4
37hepatitis a10.4
38lymphomatoid granulomatosis10.4
39aids phobia10.4
40norwegian scabies10.4
41strongyloidiasis10.4
42cryptosporidiosis10.4
43meningoencephalitis10.4
44blastomycosis10.4
45adult syndrome10.4
46oral candidiasis10.4
47malakoplakia10.4
48esophageal candidiasis10.3
49acalculous cholecystitis10.3
50porphyria cutanea tarda10.3

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to acquired immunodeficiency syndrome

Clinical Features for Acquired Immunodeficiency Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

609423

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acquired Immunodeficiency Syndrome

Drug clinical trials:

Search ClinicalTrials for Acquired Immunodeficiency Syndrome

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Search CenterWatch for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Acquired Immunodeficiency Syndrome

Anatomical Context for Acquired Immunodeficiency Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

33
Skin, Liver, Spinal cord, Brain, Lymph node, Lung, Spleen, Bone marrow, Heart, Smooth muscle, Small intestine, Colon, Thyroid, Salivary gland, Adrenal gland, Breast, Myeloid, Monocytes, T cells, B cells, Endothelial, Hypothalamus, Pituitary

Animal Models for Acquired Immunodeficiency Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TNFRSF17, MADCAM1, CD9, CD79B, CXCR5, CXCL12
2MP:000538710.5ADA, SFTPD, TNFRSF17, MPP1, MADCAM1, CD9

Publications for Acquired Immunodeficiency Syndrome

Sources:
51PubMed
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Articles related to Acquired Immunodeficiency Syndrome:

(show top 50)    (show all 899)
idTitleAuthorsYear
1
Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: A case report and review of the literature. (24257110)
2014
2
Non-cytomegalovirus ocular opportunistic infections in patients with acquired immunodeficiency syndrome. (23068916)
2013
3
Depression among people living with human immunodeficiency virus infection/acquired immunodeficiency syndrome in Benin City, Nigeria: a comparative study. (23563469)
2013
4
Prevalence and characteristics associated with malnutrition at hospitalization among patients with acquired immunodeficiency syndrome in Brazil. (23144941)
2012
5
Science and ethics of human immunodeficiency virus/acquired immunodeficiency syndrome controversies in Africa. (21951451)
2011
6
Clonal B-cell population in a reactive lymph node in acquired immunodeficiency syndrome. (19582804)
2009
7
Spontaneous regression of bowenoid papulosis in a patient with acquired immunodeficiency syndrome after an increase in peripheral CD4+ T lymphocytes. (19200210)
2009
8
Rhodococcus equi subcutaneous abscess in a patient with acquired immunodeficiency syndrome. (18181997)
2008
9
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
10
Gelatinous transformation of bone marrow in acquired immunodeficiency syndrome. (17454770)
2007
11
Rhodococcus equi infection in acquired immunodeficiency syndrome. Computed tomography aspects. (17268743)
2006
12
Proteolytic activity of IgG antibodies from blood of acquired immunodeficiency syndrome patients. (16545061)
2006
13
Presentation and outcomes of systemic non-Hodgkin's lymphoma: a comparison between patients with acquired immunodeficiency syndrome (AIDS) treated with highly active antiretroviral therapy and patients without AIDS. (17064995)
2006
14
Evaluation of stroma in human immunodeficiency virus/acquired immunodeficiency syndrome-affected bone marrows and correlation with CD4 counts. (16119986)
2005
15
Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors. (14679459)
2004
16
Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation. (15204928)
2004
17
Disseminated strongyloidiasis in a patient with acquired immunodeficiency syndrome. (15668090)
2004
18
Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. (12523893)
2003
19
Central diabetes insipidus due to cytomegalovirus infection of the hypothalamus in a patient with acquired immunodeficiency syndrome: a clinical, pathological, and immunohistochemical case study. (12519829)
2003
20
Therapeutic drug monitoring in human immunodeficiency virus/acquired immunodeficiency syndrome. Quo vadis? (12562273)
2003
21
Bilateral lesions in the basal ganglia of a patient with acquired immunodeficiency syndrome. (14521151)
2003
22
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
23
Estimation of risk of cancers before occurrence of acquired immunodeficiency syndrome in persons infected with human immunodeficiency virus. (11790679)
2002
24
Histopathology of deep-seated fungal infections and detailed examination of granulomatous response against cryptococci in patients with acquired immunodeficiency syndrome. (12145628)
2002
25
Acquired immunodeficiency syndrome in the intensive care unit: will human immunodeficiency virus-related admissions continue to decline? (12153952)
2002
26
Cavitary lung lesions due to coinfection of Rhodococcus equi and Mycobacterium kansasii in a patient with acquired immunodeficiency syndrome. (12034423)
2002
27
Pro- and anti-inflammatory cytokines in human immunodeficiency virus infection and acquired immunodeficiency syndrome. (12243799)
2002
28
Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8. (11704031)
2001
29
Disseminated Penicilliosis marneffei in a patient with acquired immunodeficiency syndrome: a first case report from China. (11776124)
2000
30
Interleukin-15 triggers activation and growth of the CD8 T-cell pool in extravascular tissues of patients with acquired immunodeficiency syndrome. (9242543)
1997
31
Therapy with a combination of intravitreal foscarnet and intravenous ganciclovir in clinically resistant cytomegalovirus retinitis and patients with acquired immunodeficiency syndrome. (9479542)
1996
32
Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome. (7995937)
1995
33
Adenosine deaminase in the cerebrospinal fluid of patients with acquired immunodeficiency syndrome]. (8729768)
1995
34
Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. (7780129)
1995
35
Tuberculous choroiditis and acquired immunodeficiency syndrome. (8010705)
1994
36
Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodeficiency syndrome. (1642470)
1992
37
Incidence of microalbuminuria in ambulatory patients with acquired immunodeficiency syndrome. (1516282)
1992
38
Circulating interferon-alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. (1996584)
1991
39
Interferon-alpha therapy in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome. (1823908)
1991
40
Profound papilledema due to cryptococcal meningitis in acquired immunodeficiency syndrome: successful treatment with fluconazole. (2000533)
1991
41
Protective effect of cyclosporin A on immune abnormalities observed in the murine acquired immunodeficiency syndrome. (1647958)
1991
42
Nontropical pyomyositis as a cause of subacute, multifocal myalgia in the acquired immunodeficiency syndrome. (2242070)
1990
43
Malignant histiocytosis in a patient with acquired immunodeficiency syndrome-related complex. (2181964)
1990
44
Bacillary (epithelioid) angiomatosis and concurrent Kaposi's sarcoma in acquired immunodeficiency syndrome. (2817918)
1989
45
Atypical granuloma annulare in patients with the acquired immunodeficiency syndrome. (2915072)
1989
46
Sporotrichosis in the acquired immunodeficiency syndrome. (2808849)
1989
47
Invasive trichosporonosis in a patient with the acquired immunodeficiency syndrome. (2760494)
1989
48
Epididymitis and the acquired immunodeficiency syndrome. (3336084)
1988
49
Norwegian scabies in acquired immunodeficiency syndrome: report of a case resulting in death from associated sepsis. (3819082)
1987
50
Broviac catheter-related infection due to Mycobacterium fortuitum in a patient with acquired immunodeficiency syndrome. (3601500)
1987

Genetic Variations for Acquired Immunodeficiency Syndrome

Expression for genes affiliated with Acquired Immunodeficiency Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acquired Immunodeficiency Syndrome

Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.

Pathways for genes affiliated with Acquired Immunodeficiency Syndrome

Compounds for genes affiliated with Acquired Immunodeficiency Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.0MS4A1, CCL3L1, CALB1, SFTPD, CSN2, TNFRSF17
2lipid4510.9SFTPD, CSN2, MPP1, CD163, CD9, CXCL12
3tyrosine4510.9CALB1, CSN2, MPP1, CD9, CD79B, CXCL12
4dexamethasone45 50 29 1113.8CALB1, SFTPD, CSN2, CD163, CXCL12, ADA
5rantes4510.8CD9, CXCR5, CXCL12
6estrogen4510.8CALB1, CSN2, CXCL12, SERPINA7, BCL6, ADA
7rituximab45 50 1112.7CXCL12, MS4A1, BCL6
8zidovudine45 1111.6CD9, CXCL12, ADA
9steroid4510.6SERPINA7, CXCL12, CSN2, SFTPD, CALB1
10paraffin4510.6BCL6, MS4A1, CD9, CD163
11didanosine45 1111.4CD9, ADA
12mdms4510.2CXCL12, CD9

GO Terms for genes affiliated with Acquired Immunodeficiency Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6MPP1, CD163, CD9, CD79B, CXCR5, MS4A1
2external side of plasma membraneGO:00989710.3CD9, CD79B, CXCL12, MS4A1, ADA

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:00756810.6ADA, SERPINA7, MADCAM1
2immune responseGO:00695510.3MS4A1, CXCL12, CXCR5, CD79B, MADCAM1

Products for genes affiliated with Acquired Immunodeficiency Syndrome

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  • Antibodies

Sources for Acquired Immunodeficiency Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet