MCID: ACQ007
MIFTS: 65

Acquired Immunodeficiency Syndrome

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Acquired Immunodeficiency Syndrome

MalaCards integrated aliases for Acquired Immunodeficiency Syndrome:

Name: Acquired Immunodeficiency Syndrome 12 3 41 14 69
Acquired Immune Deficiency Syndrome 12 72 3
Aids 12 44
Acquired Immune Deficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:635
ICD10 32 B20
MeSH 41 D000163
NCIt 46 C2851
UMLS 69 C0001175

Summaries for Acquired Immunodeficiency Syndrome

Disease Ontology : 12 A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

MalaCards based summary : Acquired Immunodeficiency Syndrome, also known as acquired immune deficiency syndrome, is related to ascaris lumbricoides infection and cytomegalovirus retinitis. An important gene associated with Acquired Immunodeficiency Syndrome is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cobicistat and Darunavir have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Help

Wikipedia : 72 Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum... more...

Related Diseases for Acquired Immunodeficiency Syndrome

Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 638)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 31.9 IFNG IL1B IL6
2 cytomegalovirus retinitis 30.7 CCR2 CCR5 CSF2 IFNG TNF
3 candidiasis 30.7 CD79A IFNG IL10
4 cytomegalovirus infection 30.5 IFNG IL10 IL6 TNF
5 syphilis 30.5 B2M CD40LG CD79A
6 kaposi sarcoma 30.4 CCR5 CSF2 IFNA1 IL6 MYC TNF
7 progressive multifocal leukoencephalopathy 30.2 CD40LG IL2 TNF
8 aids dementia complex 30.2 B2M ITIH4 TNF
9 meningoencephalitis 30.2 ALB B2M CD40LG CD79A IL6
10 pneumocystosis 30.2 ALB CD4 CD40LG CD79A TNF
11 sporotrichosis 30.2 CD40LG CD79A IFNG IL10
12 cutaneous leishmaniasis 30.2 IFNG IL10 TNF
13 laryngitis 30.2 IL1B IL6 TNF
14 hepatitis c 30.1 IFNA1 IFNG IL10 TNF
15 trichosporonosis 30.1 CSF2 IFNG TNF
16 human immunodeficiency virus type 1 30.1 B2M CCL3 CCR2 CCR5 CD38 CD4
17 aspergillosis 30.1 CD79A IFNG IL10
18 mucocutaneous leishmaniasis 30.1 CCR5 IL10 TNF
19 tuberculous peritonitis 30.1 ALB IFNG TNF
20 extrapulmonary tuberculosis 30.1 IFNG IL10 IL1B
21 herpes zoster 30.0 IFNG IL10 IL2
22 skin disease 30.0 CD79A IFNG IL10 TNF
23 leishmaniasis 30.0 IFNG IL10 IL1B TNF
24 smallpox 30.0 CSF2 IFNG IL2 TNF
25 panuveitis 30.0 CD40LG IL10 TNF
26 intussusception 30.0 CD40LG CD79A IL6
27 hepatitis b 29.9 ALB IFNA1 IFNG TNF
28 posterior uveitis 29.9 IFNG IL2 TNF
29 diarrhea 29.9 ALB CD40LG CD79A TNF
30 paracoccidioidomycosis 29.9 IFNG IL10 IL2 IL6 TNF
31 hemophagocytic lymphohistiocytosis 29.9 B2M IFNG IL10 TNF
32 bronchiolitis obliterans 29.9 IFNG IL10 IL6 TNF
33 neuritis 29.9 IFNG IL1B TNF
34 endocarditis 29.8 ALB IL10 IL6 TNF
35 kawasaki disease 29.8 ALB IL10 IL6 TNF
36 salmonellosis 29.8 ALB IFNG IL1B
37 lymphadenitis 29.7 IFNG IL10 IL1B TNF
38 gingivitis 29.7 CD79A IL1B IL6 TNF
39 central nervous system disease 29.7 CCR5 IFNG IL1B TNF
40 sclerosing cholangitis 29.7 ALB CD40LG TNF
41 arthritis 29.6 CSF2 IFNG IL10 IL1B IL6 TNF
42 spondylitis 29.6 CD40LG IL6 TNF
43 purpura 29.6 CD40LG CD79A TNF
44 lymphoma, non-hodgkin, familial 29.6 B2M CD38 CD40LG CSF2 IL2 MYC
45 cholangitis 29.6 ALB CD40LG IL6 TNF
46 prostatitis 29.5 IL10 IL1B IL6 TNF
47 appendicitis 29.5 ALB IL10 IL1B IL6 TNF
48 exanthem 29.5 CD40LG CD79A IL2 TNF
49 meningitis 29.5 ALB CD40LG IFNG IL10 IL1B IL6
50 colitis 29.4 IFNG IL10 IL1B IL2 IL6 TNF

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to Acquired Immunodeficiency Syndrome

Symptoms & Phenotypes for Acquired Immunodeficiency Syndrome

GenomeRNAi Phenotypes related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CD40LG IL10 IL1B IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CD38 CD40LG IL10 IL1B IL2 MYC

MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 ALB B2M CCR2 CCR5 CD38 CD4
2 homeostasis/metabolism MP:0005376 10.41 IL1B IL2 IL6 MYC TNF ALB
3 hematopoietic system MP:0005397 10.4 B2M CCR2 CCR5 CD38 CD4 CD40LG
4 cardiovascular system MP:0005385 10.36 B2M CCR2 CCR5 CD40LG CSF2 F9
5 immune system MP:0005387 10.36 IL6 MYC TNF IL1B IL2 B2M
6 endocrine/exocrine gland MP:0005379 10.29 ALB B2M CD38 CD4 CD40LG CSF2
7 digestive/alimentary MP:0005381 10.26 ALB B2M CCR2 CCR5 CD4 IFNG
8 mortality/aging MP:0010768 10.24 CD4 CD40LG CSF2 F9 IFNG IL10
9 liver/biliary system MP:0005370 10.22 TNF ALB B2M CCR2 CCR5 CD79A
10 neoplasm MP:0002006 10.17 ALB B2M CCR2 CCR5 CD79A CSF2
11 integument MP:0010771 10.13 B2M CD4 CD40LG CSF2 IFNG IL10
12 nervous system MP:0003631 10.07 B2M CCR2 CCR5 CD4 CD40LG CD79A
13 no phenotypic analysis MP:0003012 9.81 IL10 IL2 MYC TNF CCR2 CCR5
14 reproductive system MP:0005389 9.65 B2M CCR5 CD40LG CSF2 IFNG IL10
15 skeleton MP:0005390 9.28 IL10 IL1B IL6 MYC TNF CCR2

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

Drugs for Acquired Immunodeficiency Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1204)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobicistat Approved Phase 4,Phase 3,Phase 2,Phase 1 1004316-88-4
2
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1 635728-49-3, 206361-99-1 213039
3
Rilpivirine Approved Phase 4,Phase 2,Phase 3,Phase 1 500287-72-9
4
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 143491-57-0 60877
5
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 52485-79-7 644073 40400
6
Heroin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 561-27-3 5462328
7
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136470-78-5 441300 65140
8
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 134678-17-4 60825
9
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3056-17-5 18283
10
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 1 6493-05-6 4740
11
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
12
Rifabutin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 72559-06-9 6323490
13 Dolutegravir Approved Phase 4,Phase 3,Phase 2,Phase 1 1051375-16-6 54726191
14
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 192725-17-0 92727
15
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 155213-67-5 392622
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
17
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 154598-52-4 64139
18
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 30516-87-1 35370
19
Isoniazid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 54-85-3 3767
20
Levonorgestrel Approved, Investigational Phase 4,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
21
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 71-58-9
22
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Phase 1 723-46-6 5329
23
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 738-70-5 5578
24
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 376348-65-1 3002977
25
Artemether Approved Phase 4,Phase 3,Phase 1 71963-77-4 68911 119380
26
Lumefantrine Approved Phase 4,Phase 3,Phase 1 82186-77-4 6437380
27
Nevirapine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 129618-40-2 4463
28
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5381226 5458213
29
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
30
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159989-64-7 64143
31
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
32
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
33
Amprenavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 161814-49-9 65016
34
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 1 128794-94-5 5281078
35
Mycophenolic acid Approved Phase 4,Phase 2,Phase 1 24280-93-1 446541
36
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
37
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
38
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
39
Ezetimibe Approved Phase 4,Phase 1 163222-33-1 150311
40
Fenofibrate Approved Phase 4,Phase 3,Phase 2,Phase 1 49562-28-9 3339
41
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 81093-37-0 54687
42
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
43
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 5280965 14956
44
Ethambutol Approved Phase 4,Phase 3,Phase 2,Phase 1 74-55-5 14052 3279
45
Pyrazinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 98-96-4 1046
46
Entecavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 142217-69-4 153941
47
Desogestrel Approved Phase 4,Phase 2 54024-22-5 40973
48
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
49
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
50
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 1 54048-10-1 6917715 40976

Interventional clinical trials:

(show top 50) (show all 8692)

# Name Status NCT ID Phase Drugs
1 A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication Unknown status NCT00840762 Phase 4
2 Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults Unknown status NCT01811823 Phase 4
3 Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
4 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4 Raltegravir, tenofovir/emtricitabine
5 Integrating Buprenorphine Into HIV Treatment Unknown status NCT00241930 Phase 4
6 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4 Raltegravir and Abacavir/Lamivudine
7 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4 first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT);second line ARV therapy (3TC+TDF+LPV/RTV)
8 Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
9 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4 Buprenorphine
10 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
11 Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients Unknown status NCT01059422 Phase 4 Raltegravir; Abacavir/Lamivudine
12 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
13 Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients Unknown status NCT02370979 Phase 4
14 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
15 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
16 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
17 PI Vs. NNRTI Based Therapy for HIV Advanced Disease Unknown status NCT00162643 Phase 4 zidovudine+lamivudine+lopinavir/ritonavir;zidovudine + lamivudine + efavirenz
18 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
19 Clinical Trial on the Effects of Progestin-based Contraception in the Genital Tract of HIV-infected and Uninfected Women Unknown status NCT02103660 Phase 4 Depo-Medroxyprogesterone Acetate;Progestin Contraceptive (Jadelle)
20 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
21 Maraviroc (Celsentri) With Raltegravir and Darunavir/Ritonavir for the Treatment of Triple Class Failure in Adult HIV-1 Infected Patients Unknown status NCT01013987 Phase 4 maraviroc;Raltegravir;Darunavir/ritonavir
22 Lopinavir/Ritonavir or Efavirenz as First-line Antiretroviral Therapy Unknown status NCT01049685 Phase 4 First-line Antiretroviral Therapy
23 A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients Unknown status NCT00199121 Phase 4 Zidovudine (drug)
24 Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients Unknown status NCT00620438 Phase 4 Lumefantrine-artemether and nevirapine;lumefantrine-artemether and efavirenz;Lumefantrine-artemether and rifampicin
25 Early Antiviral Therapy for Critically Ill HIV Infected Patients Unknown status NCT01455688 Phase 4 early HAART;Late HAART
26 Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Unknown status NCT00005000 Phase 4 Nelfinavir mesylate;Efavirenz;Lamivudine;Keyhole-Limpet Hemocyanin;Stavudine;Zidovudine;Didanosine
27 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
28 Effect of a Non-tenofovir, Non-efavirenz-based HIV Regimen on Bone Density and Vitamin D Levels in African-American Patients With HIV Infection Unknown status NCT01343225 Phase 4 atripla;darunavir ritonavir raltegravir
29 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
30 BLADE: Comparison of Once Daily Lopinavir/Ritonavir to Lopinavir/Ritonavir BID Dosing in HIV-Infected Subjects Unknown status NCT00388492 Phase 4
31 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
32 Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment Unknown status NCT00005017 Phase 4 Ritonavir;Abacavir sulfate;Amprenavir;Efavirenz;Lamivudine;Stavudine
33 Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3 Unknown status NCT01235013 Phase 4 Maraviroc
34 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
35 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
36 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
37 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4 once daily minimum 3-drug regimen of anti-retroviral medications
38 Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users Unknown status NCT01105611 Phase 4 Raltegravir;Atazanavir/Ritonavir
39 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
40 Simplification From Protease Inhibitors to Raltegravir Unknown status NCT00941083 Phase 4 Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy)
41 Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status NCT00843661 Phase 4 ezetimibe;fenofibrate;pravastatin
42 Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children Unknown status NCT00604617 Phase 4 RT-23
43 RAltegravir Switch STudy: Effects on Endothelial Recovery Unknown status NCT01453933 Phase 4 raltegravir
44 Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens Unknown status NCT00940771 Phase 4 Boosted Atazanavir
45 Two Different Treatments 24 vs 48 Weeks Chronic Hepatitis C Genotypes 2 and/or 3 in co-Infected HIV-HCV Unknown status NCT00611819 Phase 4 Peg interferon + Ribavirin;Peg interferon + Ribavirin
46 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
47 Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism Unknown status NCT00759070 Phase 4 Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir
48 Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Unknown status NCT00751153 Phase 4 Raltegravir and Atazanavir
49 MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS) Unknown status NCT00122226 Phase 4 Lopinavir/ritonavir + zidovudine + lamivudine;Lopinavir/ritonavir + nevirapine
50 Effects of Raltegravir Based Regimen on Platelet Reactivity, Platelet-monocyte Aggregation and Immune Activation Unknown status NCT02383355 Phase 4 Raltegravir;Continuation of own regimen

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: acquired immunodeficiency syndrome

Genetic Tests for Acquired Immunodeficiency Syndrome

Anatomical Context for Acquired Immunodeficiency Syndrome

MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

38
Testes, T Cells, Liver, Bone, Kidney, Lung, Brain

Publications for Acquired Immunodeficiency Syndrome

Articles related to Acquired Immunodeficiency Syndrome:

(show top 50) (show all 985)
# Title Authors Year
1
Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome. ( 29419696 )
2018
2
Fecal microbiota transplantation for severe complicated C. difficile colitis in a patient with acquired immunodeficiency syndrome. ( 29449093 )
2018
3
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome. ( 29435590 )
2018
4
Epidemiological situation of acquired immunodeficiency syndrome (AIDS)-related mortality in a municipality in northeastern Brazil. A retrospective cross-sectional study. ( 29340503 )
2018
5
Promoting Cardiovascular Health in Patients Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362060 )
2018
6
Total dystrophic onychomycosis caused by<i>Talaromyces marneffei</i>in a patient with Acquired immunodeficiency syndrome on combined anti-retroviral therapy. ( 29251280 )
2018
7
Positive Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362065 )
2018
8
The Role of Faith-Based Organizations in the Education, Support, and Services for Persons Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362058 )
2018
9
Cytomegalovirus Retinitis in Patients With Acquired Immunodeficiency Syndrome After Initiating Antiretroviral Therapy. ( 27984023 )
2017
10
A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )
2017
11
The Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis: A Case Report and Review of the Literature. ( 28824078 )
2017
12
Factors affecting antiretroviral treatment adherence among people living with human immunodeficiency virus/acquired immunodeficiency syndrome: A prospective study. ( 29416993 )
2017
13
Point process methods in epidemiology: application to the analysis of human immunodeficiency virus/acquired immunodeficiency syndrome mortality in urban areas. ( 28555483 )
2017
14
Extensive brain masses and cavitary lung lesions associated with toxoplasmosis and acquired immunodeficiency syndrome. ( 28632476 )
2017
15
Imaging Findings of Common Opportunistic Infections and Malignant Tumors in Acquired Immunodeficiency Syndrome Patients. ( 29338829 )
2017
16
Sinus bradycardia induced by darunavir-ritonavir in a patient with acquired immunodeficiency syndrome. ( 28865059 )
2017
17
Uveitis as an initial manifestation of acquired immunodeficiency syndrome. ( 28201950 )
2017
18
Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome-A Rare Association. ( 29225977 )
2017
19
Toxoplasmic Encephalitis in Patient with Acquired Immunodeficiency Syndrome. ( 28516077 )
2017
20
Incidence of Intermediate-stage Age-related Macular Degeneration in Patients With Acquired Immunodeficiency Syndrome. ( 28499708 )
2017
21
Reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome. ( 28562743 )
2017
22
Case Report: Disseminated Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis Coinfection in a Japanese Patient with Acquired Immunodeficiency Syndrome. ( 28719322 )
2017
23
Advantages of Chinese medicine for patients with acquired immunodeficiency syndrome in rural central China. ( 28887810 )
2017
24
Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome. ( 28944199 )
2017
25
The End of Acquired Immunodeficiency Syndrome (AIDS) in Singapore - Are We There Yet? ( 29355281 )
2017
26
Classification of deaths in women with human immunodeficiency virus/acquired immunodeficiency syndrome in pregnancy and childbirth. ( 29160431 )
2017
27
Pathology of thyroid in acquired immunodeficiency syndrome. ( 27510660 )
2016
28
The First Case of Vestibulocochlear Neuritis in a Patient with Acquired Immunodeficiency Syndrome in Korea. ( 27433384 )
2016
29
Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome. ( 26786385 )
2016
30
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in Older Adults. ( 27394024 )
2016
31
Prevalence of Malnutrition and Associated Factors among Hospitalized Patients with Acquired Immunodeficiency Syndrome in Jimma University Specialized Hospital, Ethiopia. ( 27358542 )
2016
32
Human immunodeficiency virus (HIV) is highly associated with giant idiopathic esophageal ulcers in acquired immunodeficiency syndrome (AIDS) patients. ( 27830031 )
2016
33
Analysis and Outcomes of Cataract Surgery in Patients with Acquired Immunodeficiency Syndrome. ( 27082491 )
2016
34
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era. ( 27994425 )
2016
35
Recursion-based depletion of human immunodeficiency virus-specific naive CD4(+) T cells may facilitate persistent viral replication and chronic viraemia leading to acquired immunodeficiency syndrome. ( 27515208 )
2016
36
Frosted branch angiitis in acquired immunodeficiency syndrome patients with cytomegalovirus retinitis. ( 27640360 )
2016
37
Computer simulations of the interaction of human immunodeficiency virus (HIV) aspartic protease with spherical gold nanoparticles: implications in acquired immunodeficiency syndrome (AIDS). ( 27483476 )
2016
38
Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy. ( 28459235 )
2016
39
Food Security in Households of People Living With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Cross-sectional Study in a Subdivision of Darjeeling District, West Bengal. ( 27499166 )
2016
40
First report of Cystoisospora belli parasitemia in a patient with acquired immunodeficiency syndrome. ( 26751889 )
2016
41
Study of infections among human immunodeficiency virus/acquired immunodeficiency syndrome patients in Shadan Hospital, Telangana, India. ( 27890948 )
2016
42
Hepatic Kaposi Sarcoma Revisited: An Important but Less Commonly Seen Neoplasm in Patients With Acquired Immunodeficiency Syndrome. ( 27984514 )
2016
43
Autoimmunity and dysmetabolism of human acquired immunodeficiency syndrome. ( 26676359 )
2016
44
Central Nervous System Histoplasmosis in Acquired Immunodeficiency Syndrome. ( 26897273 )
2016
45
Pathologic lesions in children with acquired immunodeficiency syndrome an autopsy study of 11 cases from Mumbai, India. ( 27166033 )
2016
46
Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil. ( 27458037 )
2016
47
Skin aging in patients with acquired immunodeficiency syndrome. ( 27649952 )
2016
48
Opportunistic Neurologic Infections in Patients with Acquired Immunodeficiency Syndrome (AIDS). ( 26747443 )
2016
49
De Novo intracerebral aneurysm in a child with acquired immunodeficiency syndrome. ( 26818175 )
2016
50
Multiple coronary aneurysms in a young adult with acquired immunodeficiency syndrome. ( 27168940 )
2016

Variations for Acquired Immunodeficiency Syndrome

Expression for Acquired Immunodeficiency Syndrome

Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.

Pathways for Acquired Immunodeficiency Syndrome

Pathways related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 B2M CCL3 CCR2 CCR5 CD4 CD40LG
2
Show member pathways
13.94 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
3
Show member pathways
13.77 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
4
Show member pathways
13.65 CCL3 CD4 IFNA1 IFNG IL10 IL1B
5
Show member pathways
13.54 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
6
Show member pathways
13.45 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
7
Show member pathways
13.35 B2M CCL3 CCR2 CCR5 CD4 CD40LG
8
Show member pathways
12.98 B2M CD4 CD40LG IFNA1 IFNG IL10
9
Show member pathways
12.9 IFNA1 IFNG IL1B IL2 IL6 TNF
10
Show member pathways
12.79 IFNA1 IFNG IL1B IL6 TNF
11
Show member pathways
12.79 CCR5 CD4 CD40LG IFNG IL1B TNF
12
Show member pathways
12.78 CD4 CD40LG CD79A IFNG IL10 IL2
13
Show member pathways
12.78 CD4 IFNG IL10 IL1B IL2 IL6
14
Show member pathways
12.77 CD40LG IL1B IL2 IL6 TNF
15
Show member pathways
12.77 CD4 IFNG IL10 IL1B IL2 IL6
16
Show member pathways
12.7 CCR5 CSF2 IFNA1 IL6 MYC TNF
17
Show member pathways
12.69 CCL3 IFNA1 IFNG IL10 IL1B IL2
18
Show member pathways
12.62 CSF2 IFNA1 IFNG IL2 TNF
19 12.58 B2M CCR2 CD38 CD40LG CD79A IFNA1
20 12.54 CSF2 IL2 IL6 MYC TNF
21
Show member pathways
12.53 CSF2 IFNA1 IFNG IL10 IL2 IL6
22
Show member pathways
12.51 CCR5 CD4 CD40LG CSF2 IFNG IL10
23
Show member pathways
12.49 ALB IFNG IL1B IL2 IL6 TNF
24
Show member pathways
12.45 CSF2 IFNG IL1B IL6 TNF
25
Show member pathways
12.42 CCR5 CD40LG IFNG IL10 IL1B TNF
26 12.39 IFNA1 IFNG IL10 IL1B IL6 TNF
27 12.36 CD38 IFNG IL10 MYC
28
Show member pathways
12.34 IFNG IL1B IL6 TNF
29
Show member pathways
12.32 IFNA1 IFNG IL10 IL1B IL2 IL6
30
Show member pathways
12.29 IFNA1 IFNG IL1B TNF
31
Show member pathways
12.26 IFNG IL1B IL6 TNF
32 12.26 IFNG IL6 MYC TNF
33 12.26 IL10 IL1B IL6 TNF
34 12.18 CCR2 IFNG IL1B IL2 IL6 MYC
35 12.14 IL10 IL1B IL6 MYC TNF
36
Show member pathways
12.14 B2M CCL3 CCR5 CD4 IFNG IL1B
37 12.1 CD38 CD4 CSF2 IL1B IL6 TNF
38 12.09 CSF2 IFNG IL10 IL1B IL6 TNF
39 12.07 CSF2 IL1B IL6 TNF
40
Show member pathways
12.07 CD4 IFNG IL10 IL1B IL2 IL6
41 12.05 CCL3 IFNG IL1B IL6
42 12.05 CCL3 CSF2 IFNG IL1B IL6 TNF
43 12.04 CCR2 CCR5 IFNA1 IFNG IL10 IL2
44 12 CCL3 CSF2 IFNG IL1B IL6
45
Show member pathways
11.98 CD4 IFNG IL1B IL6
46 11.97 CD38 CD4 CD79A CSF2 IFNG IL10
47
Show member pathways
11.94 CD40LG CSF2 IFNG IL2 TNF
48 11.93 CSF2 IFNG IL2 IL6
49 11.9 IL10 IL1B IL6 TNF
50 11.9 CCL3 CD4 IFNG IL10 IL1B IL2

GO Terms for Acquired Immunodeficiency Syndrome

Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 B2M CCR5 CD38 CD4 CD40LG TNF
2 extracellular region GO:0005576 9.8 ALB B2M CCL3 CD40LG CSF2 F9
3 external side of plasma membrane GO:0009897 9.7 B2M CCR2 CCR5 CD4 CD40LG CD79A
4 endoplasmic reticulum lumen GO:0005788 9.65 ALB B2M CD4 F9 IL6
5 extracellular space GO:0005615 9.44 ALB B2M CCL3 CD40LG CSF2 F9

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.99 CD4 CD79A IFNA1 IFNG IL2
2 cytokine-mediated signaling pathway GO:0019221 9.97 CCR2 IFNA1 IL1B IL6
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 CD40LG IL1B IL6 TNF
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.94 CCR2 CCR5 CD38 IL2
5 positive regulation of protein phosphorylation GO:0001934 9.93 CD4 IFNG IL1B IL2 TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.91 IL10 IL1B IL6 TNF
7 chemokine-mediated signaling pathway GO:0070098 9.89 CCL3 CCR2 CCR5
8 cellular response to lipopolysaccharide GO:0071222 9.89 CCR5 CSF2 IL10 IL6 TNF
9 regulation of insulin secretion GO:0050796 9.88 IFNG IL1B TNF
10 positive regulation of inflammatory response GO:0050729 9.88 CCL3 CCR2 IL2
11 response to glucocorticoid GO:0051384 9.88 IL10 IL6 TNF
12 cellular response to organic cyclic compound GO:0071407 9.88 CCL3 IL1B MYC TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL6 MYC TNF
14 MAPK cascade GO:0000165 9.87 CCL3 CCR5 CSF2 IL1B IL2 MYC
15 positive regulation of interleukin-6 production GO:0032755 9.86 IL1B IL6 TNF
16 B cell differentiation GO:0030183 9.86 CD40LG CD79A IFNA1 IL10
17 protein kinase B signaling GO:0043491 9.85 CCL3 IL1B TNF
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 CSF2 IFNG IL2 IL6
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 IFNG IL1B TNF
20 monocyte chemotaxis GO:0002548 9.83 CCL3 CCR2 IL6
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 CSF2 IL1B TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 CCL3 IL1B TNF
23 positive regulation of interferon-gamma production GO:0032729 9.78 CCR2 IL1B IL2 TNF
24 positive regulation of T cell proliferation GO:0042102 9.77 CD4 CD40LG IL1B IL2 IL6
25 inflammatory response GO:0006954 9.76 CCL3 CCR2 CCR5 CD40LG IL10 IL1B
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG IL1B TNF
27 B cell proliferation GO:0042100 9.73 CD40LG CD79A IFNA1 IL10
28 response to cholesterol GO:0070723 9.72 CCL3 CCR5
29 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
30 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.71 CD4 CSF2
31 signaling GO:0023052 9.71 CCL3 CCR5
32 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
34 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
35 fusion of virus membrane with host plasma membrane GO:0019064 9.69 CCR5 CD4
36 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.69 CCL3 CCR5
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL10 IL1B TNF
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
39 positive regulation of interleukin-23 production GO:0032747 9.68 CSF2 IFNG
40 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
41 regulation of immunoglobulin secretion GO:0051023 9.67 CD40LG TNF
42 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
43 entry into host cell GO:0030260 9.65 CCR5 CD4
44 humoral immune response GO:0006959 9.65 CCR2 IFNA1 IFNG IL6 TNF
45 regulation of receptor activity GO:0010469 9.65 CCL3 CD40LG CSF2 IFNA1 IFNG IL10
46 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
47 regulation of vascular endothelial growth factor production GO:0010574 9.62 CCR2 IL6
48 positive regulation of vitamin D biosynthetic process GO:0060557 9.6 IFNG TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG IL1B TNF
50 immune response GO:0006955 9.44 B2M CCL3 CCR2 CCR5 CD4 CD40LG

Molecular functions related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 ALB B2M CCL3 CCR2 CCR5 CD4
2 growth factor activity GO:0008083 9.46 CSF2 IL10 IL2 IL6
3 cytokine activity GO:0005125 9.32 CCL3 CD40LG CSF2 IFNA1 IFNG IL10

Sources for Acquired Immunodeficiency Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR