AIDS
MCID: ACQ007
MIFTS: 63

Acquired Immunodeficiency Syndrome (AIDS) malady

Immune diseases category

Summaries for Acquired Immunodeficiency Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A human immunodeficiency virus infectious disease that results in reduction in the numbers of cd4-bearing helper t cells below 200 per µl of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in human immunodeficiency virus 1 or has material basis in human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. opportunistic infections are common in people with aids.

MalaCards: Acquired Immunodeficiency Syndrome, also known as AIDS, is related to sarcoma and hodgkin's lymphoma. An important gene associated with Acquired Immunodeficiency Syndrome is CXCL12 (chemokine (C-X-C motif) ligand 12). The drugs zalcitabine and didanosine and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and brain, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Daily News HIV-related news stories compiled from media sources from across the US and other countries.

Wikipedia:63 Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease of... more...

Description from OMIM:46 609423

Aliases & Classifications for Acquired Immunodeficiency Syndrome

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 38NCBI Bookshelf, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acquired immunodeficiency syndrome 8 10 60
aids 8 46 44 38
acquired immune deficiency 8


External Ids:

Disease Ontology8 DOID:635
OMIM46 609423
MeSH34 D000163
NCIt39 C2851

Related Diseases for Acquired Immunodeficiency Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 943)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.1CD163, ADA, TARDBP
2hodgkin's lymphoma30.9BCL6, MPP1, MS4A1
3pneumonia30.8SFTPD, CD9
4meningitis30.8ADA
5hepatitis30.7CXCL12, SERPINA7
6central nervous system lymphoma30.6BCL6
7dementia30.6TARDBP, CD9, CXCL12
8arthritis30.5CD163
9non-hodgkin lymphoma30.5CXCL12, MS4A1, BCL6, ADA, TNFRSF17, CXCR5
10encephalitis30.5CD9, CALB1
11thyroiditis30.5SERPINA7
12uveitis30.5CXCR5
13hepatitis c30.4CXCL12, CD9
14burkitt's lymphoma30.4ADA, BCL6
15hepatitis b30.2CD9
16leukemia30.2ADA, BCL6, CXCR5, CD79B, CD9, CXCL12
17rheumatoid arthritis30.2CXCL12, SFTPD, CD163, CXCR5, ADA, TNFRSF17
18multiple sclerosis30.2CSN2, TNFRSF17, CXCR5, CXCL12
19peritonitis30.2ADA
20immunodeficiency with hyper igm type 230.0CSN2, BCL6, SERPINA7, CD79B, CCL3L1, CALB1
21intraocular lymphoma30.0CXCR5
22myeloma30.0BCL6, TNFRSF17, CD9, CD79B, CXCR5, CXCL12
23malaria30.0MPP1
24multiple myeloma30.0CXCL12
25chronic lymphocytic leukemia29.9CD79B
26aseptic meningitis29.8CD9, ADA
27central nervous system lymphoma, primary29.8CXCR5, BCL6
28asthma29.8CXCL12, SFTPD
29plasmacytoma29.7CXCR5, BCL6, CD79B
30sepsis29.5SFTPD, CD163, CD9, CXCL12, SERPINA7
31retinitis10.8
32histoplasmosis10.7
33kaposi's sarcoma10.7
34tuberculosis10.7
35cerebritis10.6
36microsporidiosis10.6
37toxoplasmosis10.5
38candidiasis10.5
39esophagitis10.5
40pneumocystosis10.4
41pyomyositis10.4
42cryptococcosis10.4
43image syndrome10.4
44molluscum contagiosum10.4
45progressive multifocal leukoencephalopathy10.4
46granuloma annulare10.4
47scabies10.4
48norwegian scabies10.4
49strongyloidiasis10.4
50cryptosporidiosis10.4

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to acquired immunodeficiency syndrome

Clinical Features for Acquired Immunodeficiency Syndrome

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46OMIM
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Clinical features from OMIM:

609423

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acquired Immunodeficiency Syndrome

Drug clinical trials:

Search ClinicalTrials for Acquired Immunodeficiency Syndrome

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Search CenterWatch for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acquired Immunodeficiency Syndrome

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Anatomical Context for Acquired Immunodeficiency Syndrome

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32MalaCards
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MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

32
T cells, Breast, Brain, B cells, Bone, Thyroid, Bone marrow, Endothelial, Colon, Monocytes, Testes, Lung, Skin, Heart, Lymph node, Smooth muscle, Adrenal gland, Salivary gland, Small intestine, Pituitary, Liver, Spinal cord, Eye, Myeloid, Spleen, Hypothalamus

Animal Models for Acquired Immunodeficiency Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TNFRSF17, MADCAM1, CD9, CD79B, CXCR5, CXCL12
2MP:000538710.5ADA, SFTPD, TNFRSF17, MPP1, MADCAM1, CD9

Publications for Acquired Immunodeficiency Syndrome

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50PubMed
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Articles related to Acquired Immunodeficiency Syndrome:

(show top 50)    (show all 899)
idTitleAuthorsYear
1
WHO Collaborating Centre for Acquired Immunodeficiency Syndrome for the Eastern Mediterranean Regional Office, Faculty of Medicine, Kuwait University, Kuwait. (24434786)
2014
2
Meningitis and stridor in advanced Human immunodeficiency virus/acquired immune deficiency syndrome. (24049455)
2013
3
Fatal hemophagocytic syndrome as a manifestation of immune reconstitution syndrome in a patient with acquired immunodeficiency syndrome. (23974460)
2013
4
The risk of hepatocellular carcinoma among individuals with acquired immunodeficiency syndrome in the United States. (22736272)
2012
5
Fighting against acquired immunodeficiency syndrome with Chinese medicine: a perspective from China. (21611892)
2011
6
Cytomegalovirus infection presenting as a colonic mass in a patient with acquired immunodeficiency syndrome. (23754907)
2011
7
Mycobacterium tuberculosis osteomyelitis in a patient with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): a case report. (20178567)
2010
8
Case report: Esophageal histoplasmosis associated with disseminated tuberculosis in acquired immunodeficiency syndrome. (19270280)
2009
9
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector. (19544492)
2009
10
Continuing improvement in survival for children with acquired immunodeficiency syndrome in Brazil. (19672214)
2009
11
Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: in vivo confocal microscopy investigation. (19396800)
2009
12
Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting. (18028526)
2008
13
Varicella zoster meningitis in a pregnant woman with acquired immunodeficiency syndrome. (18770492)
2008
14
High rate of mutation K103N causing resistance to nevirapine in Indian children with acquired immunodeficiency syndrome. (18974494)
2008
15
Pediatric patient with systemic lupus erythematosus & congenital acquired immunodeficiency syndrome: An unusual case and a review of the literature. (18452619)
2008
16
Primary testicular non-Hodgkin's lymphoma with atrial mass as an initial presentation of acquired immunodeficiency syndrome. (17676218)
2007
17
A community randomized controlled clinical trial of mixed carotenoids and micronutrient supplementation of patients with acquired immunodeficiency syndrome. (16721396)
2006
18
Should cervical cancer be an acquired immunodeficiency syndrome-defining cancer? (16735700)
2006
19
Genotypes of JC virus, DNA of cytomegalovirus, and proviral DNA of human immunodeficiency virus in eyes of acquired immunodeficiency syndrome patients. (15804960)
2005
20
Recent advances in acquired immunodeficiency syndrome (AIDS)-related lymphoma. (16020424)
2005
21
Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma. (15578686)
2005
22
Magnetic resonance evaluation of cerebral toxoplasmosis in patients with the acquired immunodeficiency syndrome. (15191109)
2004
23
Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology. (12609827)
2003
24
T-cell receptor V beta 8.1 peptide reduces coxsackievirus-induced cardiopathology during murine acquired immunodeficiency syndrome. (12605029)
2003
25
Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndrome. (12884188)
2003
26
Risk factors for primary bacteremia and endovascular infection in patients without acquired immunodeficiency syndrome who have nontyphoid salmonellosis. (12652381)
2003
27
The prevalence of pain in pediatric human immunodeficiency virus/acquired immunodeficiency syndrome as reported by participants in the Pediatric Late Outcomes Study (PACTG 219). (12042556)
2002
28
Presumed choroidal atypical tuberculosis superinfected with cytomegalovirus retinitis in an acquired immunodeficiency syndrome patient: a case report. (12225828)
2002
29
Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome. (11703524)
2001
30
Growth failure, intracranial calcifications, acquired pancytopenia, and unusual humoral immunodeficiency: a genetic syndrome? (11074489)
2000
31
Disseminated osteoarticular sporotrichosis: treatment in a patient with acquired immunodeficiency syndrome. (10963514)
2000
32
Non-Hodgkin lymphoma in acquired immunodeficiency syndrome manifesting as bilateral hypopyon. (10025388)
1999
33
Race and the treatment of cytomegalovirus retinitis in a cohort of patients with acquired immunodeficiency syndrome. (9581441)
1998
34
Glutathione S-transferase (GSTM1) null genotype and sulphonamide intolerance in acquired immunodeficiency syndrome. (9429238)
1997
35
Abnormal expression of the B-cell homing chemokine receptor BLR1 during the progression of acquired immunodeficiency syndrome. (9226150)
1997
36
Muir-TorrAc syndrome in a patient with acquired immunodeficiency syndrome. (8776396)
1996
37
Subacute sclerosing panencephalitis and acquired immunodeficiency syndrome: role of electroencephalography and magnetic resonance imaging. (8634487)
1996
38
Cutaneous cryptococcosis with molluscum contagiosum coinfection in a patient with acquired immunodeficiency syndrome. (7851129)
1994
39
Mycobacterium marinum infection in a patient with the acquired immunodeficiency syndrome. (7956332)
1994
40
Association of herpes zoster ophthalmicus with acquired immunodeficiency syndrome and acute retinal necrosis. (8357053)
1993
41
Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. (8412739)
1993
42
The role of oral candidiasis in survival and hospitalization patterns: analysis of an inner city hospital human immunodeficiency virus/acquired immune deficiency syndrome registry. (8506895)
1993
43
Sepsis associated with Norwegian scabies in patients with acquired immunodeficiency syndrome. (1526178)
1992
44
Proinflammatory and antiinflammatory cytokines in multiple sclerosis and central nervous system acquired immunodeficiency syndrome. (1445805)
1992
45
Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS). (1281077)
1992
46
Congenital acquired immunodeficiency syndrome presenting as cor pulmonale in a 10-year-old girl. (2000766)
1991
47
Nephrotic syndrome associated with acquired immunodeficiency syndrome in children. (1941375)
1991
48
Interferon treatment of herpetic keratitis in a patient with acquired immunodeficiency syndrome. (2153343)
1990
49
Perforating granuloma annulare in a patient with acquired immunodeficiency syndrome. Immunohistologic evaluation of the cellular infiltrate. (3498442)
1987
50
Acalculous cholecystitis and cytomegalovirus infection in the acquired immunodeficiency syndrome. (3000250)
1986

Genetic Variations for Acquired Immunodeficiency Syndrome

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Expression for genes affiliated with Acquired Immunodeficiency Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Immunodeficiency Syndrome

Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.

Pathways for genes affiliated with Acquired Immunodeficiency Syndrome

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Compounds for genes affiliated with Acquired Immunodeficiency Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.0CXCL12, SFTPD, CSN2, CCL3L1, TNFRSF17, CD163
2lipid4410.9SERPINA7, CSN2, MPP1, CD163, CD9, CXCL12
3tyrosine4410.9CALB1, CSN2, MPP1, CD9, CD79B, CXCL12
4dexamethasone44 49 28 1113.8SFTPD, CALB1, CSN2, CD163, CXCL12, ADA
5rantes4410.8CXCL12, CXCR5, CD9
6estrogen4410.8ADA, CALB1, CSN2, CXCL12, SERPINA7, BCL6
7rituximab44 49 1112.7BCL6, MS4A1, CXCL12
8zidovudine44 1111.6CD9, CXCL12, ADA
9steroid4410.6SERPINA7, CXCL12, CSN2, SFTPD, CALB1
10paraffin4410.6CD163, MS4A1, BCL6, CD9
11didanosine44 1111.4ADA, CD9
12mdms4410.2CXCL12, CD9

GO Terms for genes affiliated with Acquired Immunodeficiency Syndrome

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16Gene Ontology
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Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6MPP1, CD163, CD9, CD79B, CXCR5, MS4A1
2external side of plasma membraneGO:00989710.3CD9, CD79B, CXCL12, MS4A1, ADA

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:00756810.6ADA, SERPINA7, MADCAM1
2immune responseGO:00695510.3MS4A1, CXCL12, CXCR5, CD79B, MADCAM1

Products for genes affiliated with Acquired Immunodeficiency Syndrome

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Sources for Acquired Immunodeficiency Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet