AIDS
MCID: ACQ007
MIFTS: 63

Acquired Immunodeficiency Syndrome (AIDS) malady

Immune diseases category

Summaries for Acquired Immunodeficiency Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A human immunodeficiency virus infectious disease that results in reduction in the numbers of cd4-bearing helper t cells below 200 per µl of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in human immunodeficiency virus 1 or has material basis in human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. opportunistic infections are common in people with aids.

MalaCards: Acquired Immunodeficiency Syndrome, also known as AIDS, is related to sarcoma and hodgkin's lymphoma. An important gene associated with Acquired Immunodeficiency Syndrome is CXCL12 (chemokine (C-X-C motif) ligand 12). The drugs zalcitabine and didanosine and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and brain, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Daily News HIV-related news stories compiled from media sources from across the US and other countries.

Wikipedia:63 Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease of... more...

Description from OMIM:46 609423

Aliases & Classifications for Acquired Immunodeficiency Syndrome

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8Disease Ontology, 10DISEASES, 60UMLS, 46OMIM, 44Novoseek, 38NCBI Bookshelf, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acquired immunodeficiency syndrome 8 10 60
aids 8 46 44 38
acquired immune deficiency 8


External Ids:

Disease Ontology8 DOID:635
OMIM46 609423
MeSH34 D000163
NCIt39 C2851

Related Diseases for Acquired Immunodeficiency Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 943)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.1CD163, ADA, TARDBP
2hodgkin's lymphoma30.9BCL6, MPP1, MS4A1
3pneumonia30.8SFTPD, CD9
4meningitis30.8ADA
5hepatitis30.7CXCL12, SERPINA7
6central nervous system lymphoma30.6BCL6
7dementia30.6TARDBP, CD9, CXCL12
8arthritis30.5CD163
9non-hodgkin lymphoma30.5CXCL12, MS4A1, BCL6, ADA, TNFRSF17, CXCR5
10encephalitis30.5CD9, CALB1
11thyroiditis30.5SERPINA7
12uveitis30.5CXCR5
13hepatitis c30.4CXCL12, CD9
14burkitt's lymphoma30.4ADA, BCL6
15hepatitis b30.2CD9
16leukemia30.2ADA, BCL6, CXCR5, CD79B, CD9, CXCL12
17rheumatoid arthritis30.2CXCL12, SFTPD, CD163, CXCR5, ADA, TNFRSF17
18multiple sclerosis30.2CSN2, TNFRSF17, CXCR5, CXCL12
19peritonitis30.2ADA
20immunodeficiency with hyper igm type 230.0CSN2, BCL6, SERPINA7, CD79B, CCL3L1, CALB1
21intraocular lymphoma30.0CXCR5
22myeloma30.0BCL6, TNFRSF17, CD9, CD79B, CXCR5, CXCL12
23malaria30.0MPP1
24multiple myeloma30.0CXCL12
25chronic lymphocytic leukemia29.9CD79B
26aseptic meningitis29.8CD9, ADA
27central nervous system lymphoma, primary29.8CXCR5, BCL6
28asthma29.8CXCL12, SFTPD
29plasmacytoma29.7CXCR5, BCL6, CD79B
30sepsis29.5SFTPD, CD163, CD9, CXCL12, SERPINA7
31retinitis10.8
32histoplasmosis10.7
33kaposi's sarcoma10.7
34tuberculosis10.7
35cerebritis10.6
36microsporidiosis10.6
37toxoplasmosis10.5
38candidiasis10.5
39esophagitis10.5
40pneumocystosis10.4
41pyomyositis10.4
42cryptococcosis10.4
43image syndrome10.4
44molluscum contagiosum10.4
45progressive multifocal leukoencephalopathy10.4
46granuloma annulare10.4
47scabies10.4
48norwegian scabies10.4
49strongyloidiasis10.4
50cryptosporidiosis10.4

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to acquired immunodeficiency syndrome

Clinical Features for Acquired Immunodeficiency Syndrome

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46OMIM
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Clinical features from OMIM:

609423

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acquired Immunodeficiency Syndrome

Drug clinical trials:

Search ClinicalTrials for Acquired Immunodeficiency Syndrome

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Search CenterWatch for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acquired Immunodeficiency Syndrome

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Anatomical Context for Acquired Immunodeficiency Syndrome

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32MalaCards
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MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

32
T cells, Breast, Brain, B cells, Bone, Bone marrow, Thyroid, Testes, Skin, Monocytes, Colon, Endothelial, Lung, Lymph node, Heart, Smooth muscle, Hypothalamus, Myeloid, Eye, Spleen, Adrenal gland, Salivary gland, Spinal cord, Liver, Small intestine, Pituitary

Animal Models for Acquired Immunodeficiency Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TNFRSF17, MADCAM1, CD9, CD79B, CXCR5, CXCL12
2MP:000538710.5ADA, SFTPD, TNFRSF17, MPP1, MADCAM1, CD9

Publications for Acquired Immunodeficiency Syndrome

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50PubMed
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Articles related to Acquired Immunodeficiency Syndrome:

(show top 50)    (show all 899)
idTitleAuthorsYear
1
Cure for acquired immunodeficiency syndrome-A global battle. (24352683)
2013
2
HIV-2 and its role in conglutinated approach towards Acquired Immunodeficiency Syndrome (AIDS) Vaccine Development. (23483108)
2013
3
Nucleoside reverse transcriptase inhibitors (zidovudine and stavudine) side-effects in people living with human immunodeficiency virus/acquired immunodeficiency syndrome attending the antiretroviral treatment center of B.J. Medical College and Civil Hospital at Ahmedabad, Gujarat, India. (24339470)
2013
4
Epidemiological aspects of acquired immunodeficiency syndrome in older Brazilians: a comparative approach. (22358353)
2012
5
A case of Good's syndrome: a rare acquired immunodeficiency associated with thymoma. (21587135)
2011
6
Extra-uterine myoid tumours in patients with acquired immunodeficiency syndrome: a clinicopathological reappraisal. (22175892)
2011
7
Images in the medical sciences. Night blindness in a patient with acquired immunodeficiency syndrome. (19884817)
2010
8
Dermoscopy of Norwegian scabies in a patient with acquired immunodeficiency syndrome. (20520938)
2010
9
Psychiatric diagnosis and antiretroviral adherence among adolescent Medicaid beneficiaries diagnosed with human immunodeficiency virus/acquired immunodeficiency syndrome. (19440109)
2009
10
Lipodystrophy in children and adolescents with acquired immunodeficiency syndrome and its relationship with the antiretroviral therapy employed. (19668909)
2009
11
High early mortality in patients with chronic acquired immunodeficiency syndrome diarrhea initiating antiretroviral therapy in Haiti: a case-control study. (19478276)
2009
12
Case of moyamoya disease in a patient with advanced acquired immunodeficiency syndrome. (18035245)
2007
13
Pulmonary embolism in patients with acquired immunodeficiency syndrome presenting with clinical picture of Pneumocystis jiroveci pneumonia: report of two cases. (17577835)
2007
14
A patient with acquired immunodeficiency syndrome (AIDS) and a cutaneous Mycobacterium avium intracellulare infection mimicking histoid leprosy. (17667188)
2007
15
Histoplasma capsulatum fungemia in patients with acquired immunodeficiency syndrome: detection by lysis-centrifugation blood-culturing technique. (17625688)
2007
16
Acquired immunodeficiency syndrome-related malignancies in the era of highly active antiretroviral therapy. (16867895)
2006
17
Current therapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome. (16867897)
2006
18
Acquired immunodeficiency syndrome-related lymphoma: simultaneous treatment with combined cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy and highly active antiretroviral therapy is safe and improves survival--results of the German Multicenter Trial. (16502436)
2006
19
Acquired immunodeficiency syndrome: manifestations in the oral cavity. (15580133)
2004
20
Massive peripapillary retinal haemorrahge in a case of acquired immunodeficiency syndrome. (15693334)
2004
21
Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. (17041454)
2003
22
Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome. (11781257)
2002
23
Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia. (11920506)
2002
24
Association of adherence to Mycobacterium avium complex prophylaxis and antiretroviral therapy with clinical outcomes in Acquired Immunodeficiency Syndrome. (11915003)
2002
25
Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome. (12585977)
2002
26
Retinal detachment risk in cytomegalovirus retinitis related to the acquired immunodeficiency syndrome. (11146724)
2001
27
A preliminary report on basal & stimulated plasma cortisol in patients with acquired immunodeficiency syndrome. (12452125)
2000
28
Zinc protoporphyrin and percentage of hypochromic erythrocytes as markers of functional iron deficiency during therapy with erythropoietin in patients with advanced acquired immunodeficiency syndrome. (10624905)
1999
29
Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. (9578085)
1998
30
MSL-109 adjuvant therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: the Monoclonal Antibody Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS Research Group. AIDS Clinical Trials Group. (9400786)
1997
31
Severe pulmonary pneumocystosis in simian acquired immunodeficiency syndrome induced by simian immunodeficiency virus. (9508438)
1997
32
CD8+ T lymphocyte counts as an adjunctive predictor of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. (9240493)
1997
33
Serum interleukin-10 in acquired immunodeficiency syndrome lymphoma patients. Seroco-Hemoco Study Group. (9010682)
1996
34
Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas. (8043869)
1994
35
Intestinal microsporidiosis in patients with acquired immunodeficiency syndrome--report of three more German cases. (7698840)
1994
36
Rochalimaea henselae infection in acquired immunodeficiency syndrome causing inflammatory disease without angiomatosis or peliosis. Demonstration by immunocytochemistry and corroboration by DNA amplification. (7506902)
1994
37
Fine-needle detection of cytomegalovirus parotitis in a patient with acquired immunodeficiency syndrome. (8166971)
1994
38
Acanthamoeba infection presenting as skin lesions in patients with the acquired immunodeficiency syndrome. (8215828)
1993
39
Progressive ocular toxoplasmosis in patients with acquired immunodeficiency syndrome. (8506909)
1993
40
Isosporiasis in Venezuela: a report of two cases in patients with acquired immunodeficiency syndrome. (8284609)
1993
41
Cytokine expression in the brain during the acquired immunodeficiency syndrome. (1586135)
1992
42
Expression of interleukin 2 receptors by monocytes from patients with acquired immunodeficiency syndrome and induction of monocyte interleukin 2 receptors by human immunodeficiency virus in vitro. (2295695)
1990
43
Severe pulmonary hypertension and cor pulmonale in the acquired immunodeficiency syndrome. (2531539)
1989
44
Chronic meningitis and vasculitis in acquired immunodeficiency syndrome. (2774861)
1989
45
Declining rates of amebiasis in Los Angeles County: a sentinel for decreasing acquired immunodeficiency syndrome (AIDS) incidence? (2817176)
1989
46
Bacteremia and ecthyma caused by Streptococcus pyogenes in a patient with acquired immunodeficiency syndrome. (3276190)
1988
47
Acquired immunodeficiency syndrome presenting as disseminated cutaneous sporotrichosis. (3229884)
1988
48
Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. (3030113)
1987
49
Membranoproliferative glomerulonephritis and plexogenic pulmonary arteriopathy in a homosexual man with acquired immunodeficiency syndrome. (3679202)
1987
50
Eosinophilic vasculitis leading to amaurosis fugax in a patient with acquired immunodeficiency syndrome. (3767551)
1986

Genetic Variations for Acquired Immunodeficiency Syndrome

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Expression for genes affiliated with Acquired Immunodeficiency Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Immunodeficiency Syndrome

Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.

Pathways for genes affiliated with Acquired Immunodeficiency Syndrome

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Compounds for genes affiliated with Acquired Immunodeficiency Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.0MS4A1, CCL3L1, CALB1, SFTPD, CSN2, TNFRSF17
2lipid4410.9SFTPD, CSN2, MPP1, CD163, CD9, CXCL12
3tyrosine4410.9CALB1, CSN2, MPP1, CD9, CD79B, CXCL12
4dexamethasone44 49 28 1113.8CALB1, SFTPD, CSN2, CD163, CXCL12, ADA
5rantes4410.8CD9, CXCR5, CXCL12
6estrogen4410.8CALB1, CSN2, CXCL12, SERPINA7, BCL6, ADA
7rituximab44 49 1112.7CXCL12, MS4A1, BCL6
8zidovudine44 1111.6CD9, CXCL12, ADA
9steroid4410.6SERPINA7, CXCL12, CSN2, SFTPD, CALB1
10paraffin4410.6BCL6, MS4A1, CD9, CD163
11didanosine44 1111.4CD9, ADA
12mdms4410.2CXCL12, CD9

GO Terms for genes affiliated with Acquired Immunodeficiency Syndrome

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16Gene Ontology
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Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6CD163, CD9, CD79B, CXCR5, MS4A1, MPP1
2external side of plasma membraneGO:00989710.3ADA, MS4A1, CXCL12, CD79B, CD9

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:00756810.6ADA, SERPINA7, MADCAM1
2immune responseGO:00695510.3MS4A1, CXCL12, CXCR5, CD79B, MADCAM1

Products for genes affiliated with Acquired Immunodeficiency Syndrome

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  • Antibodies
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Sources for Acquired Immunodeficiency Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet