MCID: ACQ007
MIFTS: 60

Acquired Immunodeficiency Syndrome

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Acquired Immunodeficiency Syndrome

MalaCards integrated aliases for Acquired Immunodeficiency Syndrome:

Name: Acquired Immunodeficiency Syndrome 12 3 42 14 69
Acquired Immune Deficiency Syndrome 12 3
Aids 12 45
Acquired Immune Deficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:635
ICD10 33 B20
MeSH 42 D000163
NCIt 47 C2851
UMLS 69 C0001175

Summaries for Acquired Immunodeficiency Syndrome

Disease Ontology : 12 A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

MalaCards based summary : Acquired Immunodeficiency Syndrome, also known as acquired immune deficiency syndrome, is related to toxoplasmosis and cryptococcosis. An important gene associated with Acquired Immunodeficiency Syndrome is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cobicistat and Darunavir have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cellular

CDC : 3 Help

Related Diseases for Acquired Immunodeficiency Syndrome

Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 647)
id Related Disease Score Top Affiliating Genes
1 toxoplasmosis 31.2 IFNA1 IL6 TNF
2 cryptococcosis 30.6 CD40LG IL10 TNF
3 uveitis 30.5 CD40LG CD79A TNF
4 extrapulmonary tuberculosis 30.4 CD40LG CD79A IL10
5 hepatitis b 30.3 B2M IFNG IL10 TNF
6 chorioretinitis 30.1 CD40LG IFNA1
7 granuloma annulare 29.9 ALB CD40LG CD79A IL1B
8 glioblastoma multiforme 29.9 CD40LG IL10 TNF
9 kaposi sarcoma 29.8 CD40LG CD79A IL1B IL6 TNF
10 calciphylaxis 29.8 ALB IL1B IL6
11 noma 29.8 IL10 IL1B IL6 TNF
12 choroiditis 29.7 ALB IL10 IL1B IL6 TNF
13 hemophagocytic lymphohistiocytosis 29.6 IFNG IL10 IL2 IL6 TNF
14 cataract 29.6 ALB CSF2 IL1B TNF
15 mucocutaneous leishmaniasis 29.6 ALB IFNG IL10 IL2 TNF
16 hypertrichosis 29.5 ALB IL1B IL6 TNF
17 scabies 29.4 ALB B2M IFNG IL10 IL1B IL6
18 membranoproliferative glomerulonephritis 29.3 CD40LG CD79A IFNG IL2 TNF
19 atherosclerosis 29.3 CSF2 IFNG IL10 IL1B IL6 TNF
20 lymphoma 29.0 ALB CD40LG CD79A IFNG IL10 IL1B
21 pulmonary embolism 28.4 ALB CD40LG IFNG IL10 IL1B IL6
22 systemic lupus erythematosus 28.4 ALB CD40LG CD79A IFNA1 IFNG IL10
23 malaria 26.7 ALB CCL3 CD40LG CSF2 IFNG IL10
24 rheumatoid arthritis 26.4 CCL3 CCR2 CD40LG CD79A CSF2 IFNG
25 aids - neurological complications 12.0
26 hiv-1 11.1
27 primary central nervous system lymphoma 11.1
28 atopic dermatitis 5 10.9 ALB CD79A
29 malignant renovascular hypertension 10.9 CD79A IFNG
30 ovary transitional cell carcinoma 10.9 ALB CD79A
31 non-congenital cyst of kidney 10.9 ALB B2M CD79A
32 herpangina 10.8 IFNG IL10 IL6
33 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.8 IFNG IL10 IL6
34 eye accommodation disease 10.8 IFNG IL10
35 crustacean allergy 10.8 CCR5 CD79A IL10
36 diffuse glomerulonephritis 10.8 CD79A IFNG IL6
37 pure autonomic failure 10.8 IL10 TNF
38 loiasis 10.8 CD79A IFNG IL10
39 cataract 25 10.8 ALB B2M
40 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
41 erythema multiforme 10.8 ALB CCR5 IL10
42 epidermolysis bullosa acquisita 10.8 ALB IFNG IL10
43 efavirenz, poor metabolism of 10.8
44 oral hairy leukoplakia 10.8
45 solitary plasmacytoma of chest wall 10.8 B2M IL2 IL6
46 chronic endophthalmitis 10.8 ALB CSF2 IL6
47 acute ackee fruit intoxication 10.8 IL10 TNF
48 congenital dyserythropoietic anemia 10.8 ALB TNF
49 breast papillary carcinoma 10.8 ALB IL10 IL6
50 alcoholic neuropathy 10.8 CD40LG CD79A

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to Acquired Immunodeficiency Syndrome

Symptoms & Phenotypes for Acquired Immunodeficiency Syndrome

GenomeRNAi Phenotypes related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL1B IL2 TNF CD40LG IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 IL2 MYC TNF CD38 CD40LG IL10

MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 CCR5 CD38 CD4 CD40LG CD79A CSF2
2 homeostasis/metabolism MP:0005376 10.41 TNF ALB B2M CCR2 CCR5 CD38
3 hematopoietic system MP:0005397 10.4 CSF2 F9 IFNG IL10 IL1B IL2
4 cardiovascular system MP:0005385 10.36 B2M CCR2 CCR5 CD40LG CSF2 F9
5 immune system MP:0005387 10.36 B2M CCR2 CCR5 CD38 CD4 CD40LG
6 endocrine/exocrine gland MP:0005379 10.29 CD4 CD40LG CSF2 IFNG IL10 IL2
7 digestive/alimentary MP:0005381 10.26 ALB B2M CCR2 CCR5 CD4 IFNG
8 mortality/aging MP:0010768 10.24 ALB B2M CCR2 CCR5 CD4 CD40LG
9 liver/biliary system MP:0005370 10.22 ALB B2M CCR2 CCR5 CD79A F9
10 neoplasm MP:0002006 10.17 IFNG IL10 IL1B IL2 IL6 ITIH4
11 integument MP:0010771 10.13 CSF2 IFNG IL10 IL1B IL6 MYC
12 nervous system MP:0003631 10.07 CD79A CSF2 IFNG IL10 IL1B IL6
13 no phenotypic analysis MP:0003012 9.81 CCR2 CCR5 CD4 CD79A IFNG IL10
14 reproductive system MP:0005389 9.65 CCR5 CD40LG CSF2 IFNG IL10 IL2
15 skeleton MP:0005390 9.28 CCR2 CD40LG CSF2 IFNG IL10 IL1B

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

Drugs for Acquired Immunodeficiency Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1186)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobicistat Approved Phase 4,Phase 3,Phase 2,Phase 1 1004316-88-4
2
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1 635728-49-3, 206361-99-1 213039
3
Rilpivirine Approved Phase 4,Phase 2,Phase 3,Phase 1 500287-72-9
4
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 52485-79-7 40400 644073
5
Heroin Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 561-27-3 5462328
6
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 143491-57-0 60877
7
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 134678-17-4 60825
8
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3056-17-5 18283
9
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136470-78-5 65140 441300
10
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 154598-52-4 64139
11
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 192725-17-0 92727
12
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 155213-67-5 392622
13
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 30516-87-1 35370
14
Rifabutin Approved Phase 4,Phase 2,Phase 3,Phase 1 72559-06-9 6323490
15
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 1 6493-05-6 4740
16
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
17
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
18 Dolutegravir Approved Phase 4,Phase 3,Phase 2,Phase 1 1051375-16-6 54726191
19
Isoniazid Approved Phase 4,Phase 3,Phase 2,Phase 1 54-85-3 3767
20
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Phase 1 723-46-6 5329
21
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 738-70-5 5578
22
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 376348-65-1 3002977
23
Artemether Approved Phase 4,Phase 3,Phase 1 71963-77-4 119380 68911
24
Lumefantrine Approved Phase 4,Phase 3,Phase 1 82186-77-4 6437380
25
Nevirapine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 129618-40-2 4463
26
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5458213 5381226
27
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
28
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159989-64-7 64143
29
Amprenavir Approved Phase 4,Phase 2,Phase 3,Phase 1 161814-49-9 65016
30
Candesartan Approved Phase 4 139481-59-7 2541
31
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
32
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 1 128794-94-5 5281078
33
Mycophenolic acid Approved Phase 4,Phase 2,Phase 1 24280-93-1 446541
34
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
35
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
36
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
37
Ezetimibe Approved Phase 4,Phase 1 163222-33-1 150311
38
Fenofibrate Approved Phase 4,Phase 3,Phase 2,Phase 1 49562-28-9 3339
39
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 81093-37-0 54687
40
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
41
Ethambutol Approved Phase 4,Phase 3,Phase 2,Phase 1 74-55-5 3279 14052
42
Pyrazinamide Approved Phase 4,Phase 3,Phase 2,Phase 1 98-96-4 1046
43
Entecavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 142217-69-4 153941
44
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
45
Desogestrel Approved Phase 4,Phase 2 54024-22-5 40973
46
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
47
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
48
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 1 54048-10-1 40976 6917715
49
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
50
Capsaicin Approved Phase 4,Phase 3,Phase 2 404-86-4 1548943

Interventional clinical trials:

(show top 50) (show all 8512)

id Name Status NCT ID Phase Drugs
1 A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication Unknown status NCT00840762 Phase 4
2 Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults Unknown status NCT01811823 Phase 4
3 Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
4 Integrating Buprenorphine Into HIV Treatment Unknown status NCT00241930 Phase 4
5 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4 Raltegravir, tenofovir/emtricitabine
6 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4 first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT);second line ARV therapy (3TC+TDF+LPV/RTV)
7 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4 Raltegravir and Abacavir/Lamivudine
8 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4 Buprenorphine
9 Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
10 PI Vs. NNRTI Based Therapy for HIV Advanced Disease Unknown status NCT00162643 Phase 4 zidovudine+lamivudine+lopinavir/ritonavir;zidovudine + lamivudine + efavirenz
11 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
12 Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients Unknown status NCT01059422 Phase 4 Raltegravir; Abacavir/Lamivudine
13 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
14 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
15 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
16 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
17 Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients Unknown status NCT02370979 Phase 4
18 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
19 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
20 Maraviroc (Celsentri) With Raltegravir and Darunavir/Ritonavir for the Treatment of Triple Class Failure in Adult HIV-1 Infected Patients Unknown status NCT01013987 Phase 4 maraviroc;Raltegravir;Darunavir/ritonavir
21 A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients Unknown status NCT00199121 Phase 4 Zidovudine (drug)
22 Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients Unknown status NCT00620438 Phase 4 Lumefantrine-artemether and nevirapine;lumefantrine-artemether and efavirenz;Lumefantrine-artemether and rifampicin
23 Lopinavir/Ritonavir or Efavirenz as First-line Antiretroviral Therapy Unknown status NCT01049685 Phase 4 First-line Antiretroviral Therapy
24 Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Unknown status NCT00005000 Phase 4 Nelfinavir mesylate;Efavirenz;Lamivudine;Keyhole-Limpet Hemocyanin;Stavudine;Zidovudine;Didanosine
25 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
26 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
27 Evaluation of the Efficacy and Safety Between Two Antiretroviral Regimens, in HIV-1-infected Treatment-naïve Subjects With Low CD4 Counts Unknown status NCT01928407 Phase 4 DARUNAVIR;ATAZANAVIR
28 Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment Unknown status NCT00005017 Phase 4 Ritonavir;Abacavir sulfate;Amprenavir;Efavirenz;Lamivudine;Stavudine
29 Early Antiviral Therapy for Critically Ill HIV Infected Patients Unknown status NCT01455688 Phase 4 early HAART;Late HAART
30 BLADE: Comparison of Once Daily Lopinavir/Ritonavir to Lopinavir/Ritonavir BID Dosing in HIV-Infected Subjects Unknown status NCT00388492 Phase 4
31 Effect of a Non-tenofovir, Non-efavirenz-based HIV Regimen on Bone Density and Vitamin D Levels in African-American Patients With HIV Infection Unknown status NCT01343225 Phase 4 atripla;darunavir ritonavir raltegravir
32 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
33 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
34 Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3 Unknown status NCT01235013 Phase 4 Maraviroc
35 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4 once daily minimum 3-drug regimen of anti-retroviral medications
36 Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users Unknown status NCT01105611 Phase 4 Raltegravir;Atazanavir/Ritonavir
37 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
38 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
39 The Self-Collection Study: a Study of Self-collected HPV Testing and Results Counseling Unknown status NCT01843478 Phase 4
40 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
41 Simplification From Protease Inhibitors to Raltegravir Unknown status NCT00941083 Phase 4 Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy)
42 Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status NCT00843661 Phase 4 ezetimibe;fenofibrate;pravastatin
43 Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children Unknown status NCT00604617 Phase 4 RT-23
44 Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens Unknown status NCT00940771 Phase 4 Boosted Atazanavir
45 RAltegravir Switch STudy: Effects on Endothelial Recovery Unknown status NCT01453933 Phase 4 raltegravir
46 Two Different Treatments 24 vs 48 Weeks Chronic Hepatitis C Genotypes 2 and/or 3 in co-Infected HIV-HCV Unknown status NCT00611819 Phase 4 Peg interferon + Ribavirin;Peg interferon + Ribavirin
47 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
48 Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism Unknown status NCT00759070 Phase 4 Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir
49 Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Unknown status NCT00751153 Phase 4 Raltegravir and Atazanavir
50 MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS) Unknown status NCT00122226 Phase 4 Lopinavir/ritonavir + zidovudine + lamivudine;Lopinavir/ritonavir + nevirapine

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: acquired immunodeficiency syndrome

Genetic Tests for Acquired Immunodeficiency Syndrome

Anatomical Context for Acquired Immunodeficiency Syndrome

MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

39
Testes, T Cells, Liver, Bone, Kidney, Lung, Brain

Publications for Acquired Immunodeficiency Syndrome

Articles related to Acquired Immunodeficiency Syndrome:

(show top 50) (show all 973)
id Title Authors Year
1
Extensive brain masses and cavitary lung lesions associated with toxoplasmosis and acquired immunodeficiency syndrome. ( 28632476 )
2017
2
The Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis: A Case Report and Review of the Literature. ( 28824078 )
2017
3
Case Report: Disseminated Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis Coinfection in a Japanese Patient with Acquired Immunodeficiency Syndrome. ( 28719322 )
2017
4
Point process methods in epidemiology: application to the analysis of human immunodeficiency virus/acquired immunodeficiency syndrome mortality in urban areas. ( 28555483 )
2017
5
Sinus bradycardia induced by darunavir-ritonavir in a patient with acquired immunodeficiency syndrome. ( 28865059 )
2017
6
A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )
2017
7
Cytomegalovirus Retinitis in Patients With Acquired Immunodeficiency Syndrome After Initiating Antiretroviral Therapy. ( 27984023 )
2017
8
Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome. ( 28944199 )
2017
9
Uveitis as an initial manifestation of acquired immunodeficiency syndrome. ( 28201950 )
2017
10
Toxoplasmic Encephalitis in Patient with Acquired Immunodeficiency Syndrome. ( 28516077 )
2017
11
Advantages of Chinese medicine for patients with acquired immunodeficiency syndrome in rural central China. ( 28887810 )
2017
12
Reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome. ( 28562743 )
2017
13
Incidence of Intermediate-stage Age-related Macular Degeneration in Patients With Acquired Immunodeficiency Syndrome. ( 28499708 )
2017
14
Opportunistic Neurologic Infections in Patients with Acquired Immunodeficiency Syndrome (AIDS). ( 26747443 )
2016
15
Analysis and Outcomes of Cataract Surgery in Patients with Acquired Immunodeficiency Syndrome. ( 27082491 )
2016
16
Miliary tuberculosis and acquired immunodeficiency syndrome - 'a cursed duet'. ( 27802849 )
2016
17
Skin aging in patients with acquired immunodeficiency syndrome. ( 27649952 )
2016
18
Frosted branch angiitis in acquired immunodeficiency syndrome patients with cytomegalovirus retinitis. ( 27640360 )
2016
19
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. ( 26962942 )
2016
20
Hepatic Kaposi Sarcoma Revisited: An Important but Less Commonly Seen Neoplasm in Patients With Acquired Immunodeficiency Syndrome. ( 27984514 )
2016
21
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in Older Adults. ( 27394024 )
2016
22
Recursion-based depletion of human immunodeficiency virus-specific naive CD4(+) T cells may facilitate persistent viral replication and chronic viraemia leading to acquired immunodeficiency syndrome. ( 27515208 )
2016
23
Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil. ( 27458037 )
2016
24
Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy. ( 28459235 )
2016
25
Central Nervous System Histoplasmosis in Acquired Immunodeficiency Syndrome. ( 26897273 )
2016
26
The First Case of Vestibulocochlear Neuritis in a Patient with Acquired Immunodeficiency Syndrome in Korea. ( 27433384 )
2016
27
Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome. ( 26786385 )
2016
28
Pathologic lesions in children with acquired immunodeficiency syndrome an autopsy study of 11 cases from Mumbai, India. ( 27166033 )
2016
29
Pathology of thyroid in acquired immunodeficiency syndrome. ( 27510660 )
2016
30
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era. ( 27994425 )
2016
31
Computer simulations of the interaction of human immunodeficiency virus (HIV) aspartic protease with spherical gold nanoparticles: implications in acquired immunodeficiency syndrome (AIDS). ( 27483476 )
2016
32
De Novo intracerebral aneurysm in a child with acquired immunodeficiency syndrome. ( 26818175 )
2016
33
First report of Cystoisospora belli parasitemia in a patient with acquired immunodeficiency syndrome. ( 26751889 )
2016
34
Autoimmunity and dysmetabolism of human acquired immunodeficiency syndrome. ( 26676359 )
2016
35
Multiple coronary aneurysms in a young adult with acquired immunodeficiency syndrome. ( 27168940 )
2016
36
Food Security in Households of People Living With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Cross-sectional Study in a Subdivision of Darjeeling District, West Bengal. ( 27499166 )
2016
37
Prevalence of Malnutrition and Associated Factors among Hospitalized Patients with Acquired Immunodeficiency Syndrome in Jimma University Specialized Hospital, Ethiopia. ( 27358542 )
2016
38
Human immunodeficiency virus (HIV) is highly associated with giant idiopathic esophageal ulcers in acquired immunodeficiency syndrome (AIDS) patients. ( 27830031 )
2016
39
Study of infections among human immunodeficiency virus/acquired immunodeficiency syndrome patients in Shadan Hospital, Telangana, India. ( 27890948 )
2016
40
Longitudinal Melanonychia in an African Patient with Acquired Immunodeficiency Syndrome (AIDS). ( 26137665 )
2015
41
Co-infections with Ureaplasma parvum and Herpes simplex virus in an acquired immunodeficiency syndrome patient. ( 26392670 )
2015
42
Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report. ( 25542475 )
2015
43
Ocular Manifestations of Acquired Immunodeficiency Syndrome. ( 26240508 )
2015
44
A Clinical Study of Acquired Immunodeficiency Syndrome Associated Penicillium Marneffei Infection from a Non-Endemic Area in China. ( 26083736 )
2015
45
Public perceptions about HIV/AIDS and discriminatory attitudes toward people living with acquired immunodeficiency syndrome in Iran. ( 26726933 )
2015
46
De Novo intracerebral aneurysm in a child with acquired immunodeficiency syndrome. ( 26166600 )
2015
47
Prevalence of Intermediate-Stage Age-Related Macular Degeneration in Patients With Acquired Immunodeficiency Syndrome. ( 25769246 )
2015
48
Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective. ( 26798547 )
2015
49
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Risk (HIV/AIDS)-Taking Behavior and HIV/AIDS Knowledge With African-American Women. ( 26870711 )
2015
50
Retrospective study of cytomegalovirus retinitis complicated with acquired immunodeficiency syndrome. ( 26309620 )
2015

Variations for Acquired Immunodeficiency Syndrome

Expression for Acquired Immunodeficiency Syndrome

Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.

Pathways for Acquired Immunodeficiency Syndrome

Pathways related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 B2M CCL3 CCR2 CCR5 CD4 CD40LG
2
Show member pathways
13.96 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
3
Show member pathways
13.77 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
4
Show member pathways
13.65 CCL3 CD4 IFNA1 IFNG IL10 IL1B
5
Show member pathways
13.54 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
6
Show member pathways
13.45 CCL3 CCR2 CCR5 CD4 CD40LG CSF2
7
Show member pathways
13.35 B2M CCL3 CCR2 CCR5 CD4 CD40LG
8
Show member pathways
13.03 CCL3 IFNA1 IFNG IL10 IL1B IL2
9
Show member pathways
12.98 B2M CD4 CD40LG IFNA1 IFNG IL10
10
Show member pathways
12.9 IFNA1 IFNG IL1B IL2 IL6 TNF
11
Show member pathways
12.79 IFNA1 IFNG IL1B IL6 TNF
12
Show member pathways
12.78 CCR5 CD4 CD40LG IFNG IL1B TNF
13
Show member pathways
12.78 CD4 CD40LG CD79A IFNG IL10 IL2
14
Show member pathways
12.78 CD4 IFNG IL10 IL1B IL2 IL6
15
Show member pathways
12.77 CD4 IFNG IL10 IL1B IL2 IL6
16
Show member pathways
12.76 CD40LG IL1B IL2 IL6 TNF
17
Show member pathways
12.61 CSF2 IFNA1 IFNG IL2 TNF
18 12.56 B2M CCR2 CD38 CD40LG CD79A IFNA1
19 12.53 CSF2 IL2 IL6 MYC TNF
20
Show member pathways
12.51 CCR5 CD4 CD40LG CSF2 IFNG IL10
21
Show member pathways
12.45 CSF2 IFNG IL1B IL6 TNF
22
Show member pathways
12.41 CCR5 CD40LG IFNG IL10 IL1B TNF
23 12.39 IFNA1 IFNG IL10 IL1B IL6 TNF
24
Show member pathways
12.38 CSF2 IFNA1 IFNG IL10 IL2 IL6
25 12.36 CD38 IFNG IL10 MYC
26
Show member pathways
12.34 IFNG IL1B IL6 TNF
27
Show member pathways
12.32 IFNA1 IFNG IL10 IL1B IL2 IL6
28
Show member pathways
12.26 IFNG IL1B IL6 TNF
29 12.26 IFNG IL6 MYC TNF
30 12.25 IL10 IL1B IL6 TNF
31 12.18 CCR2 IFNG IL1B IL2 IL6 MYC
32
Show member pathways
12.14 B2M CCL3 CCR5 CD4 IFNG IL1B
33 12.13 IL10 IL1B IL6 MYC TNF
34 12.09 CD38 CD4 CSF2 IL1B IL6 TNF
35 12.08 CSF2 IFNG IL10 IL1B IL6 TNF
36
Show member pathways
12.08 CD4 IFNG IL10 IL1B IL2 IL6
37 12.07 CCR2 CCR5 IFNA1 IFNG IL10 IL2
38 12.06 CSF2 IL1B IL6 TNF
39 12.05 CCL3 IFNG IL1B IL6
40 12.05 CCL3 CSF2 IFNG IL1B IL6 TNF
41
Show member pathways
12.03 CD4 IFNG IL1B IL6
42 12 CCL3 CSF2 IFNG IL1B IL6
43 11.98 CD38 CD4 CD79A CSF2 IFNG IL10
44
Show member pathways
11.94 CD40LG CSF2 IFNG IL2 TNF
45 11.93 CSF2 IFNG IL2 IL6
46 11.9 CCL3 CD4 IFNG IL10 IL1B IL2
47 11.89 IL10 IL1B IL6 TNF
48 11.85 CD40LG IL10 IL6 TNF
49 11.85 CCL3 CCR2 CSF2 IL1B IL6 TNF
50
Show member pathways
11.78 B2M IFNG IL2 TNF

GO Terms for Acquired Immunodeficiency Syndrome

Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 B2M CCR5 CD38 CD4 CD40LG TNF
2 extracellular space GO:0005615 9.77 ALB B2M CCL3 CD40LG CSF2 F9
3 endoplasmic reticulum lumen GO:0005788 9.65 ALB B2M CD4 F9 IL6
4 external side of plasma membrane GO:0009897 9.23 B2M CCR5 CD4 CD40LG CD79A IFNG
5 extracellular region GO:0005576 10 ALB B2M CCL3 CD40LG CSF2 F9

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 CCR2 IFNA1 IL1B IL6
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.97 CCR2 CCR5 CD38 IL2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 CD40LG IL1B IL6 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.96 CD4 IFNG IL1B IL2 TNF
5 positive regulation of gene expression GO:0010628 9.95 CCL3 CSF2 IFNG IL1B IL6 MYC
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.92 IL10 IL1B IL6 TNF
7 cellular response to organic cyclic compound GO:0071407 9.91 CCL3 IL1B TNF
8 chemokine-mediated signaling pathway GO:0070098 9.91 CCL3 CCR2 CCR5
9 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
10 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
11 neutrophil chemotaxis GO:0030593 9.89 CCL3 IFNG IL1B
12 positive regulation of inflammatory response GO:0050729 9.89 CCL3 CCR2 IL2
13 response to cytokine GO:0034097 9.88 CD38 IL6 ITIH4
14 B cell differentiation GO:0030183 9.88 CD40LG CD79A IFNA1 IL10
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 CSF2 IFNG IL2 IL6
16 MAPK cascade GO:0000165 9.87 CCL3 CCR5 CSF2 IL1B IL2 MYC
17 positive regulation of interleukin-6 production GO:0032755 9.86 IL1B IL6 TNF
18 humoral immune response GO:0006959 9.85 IFNA1 IFNG IL6 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 CSF2 IL1B TNF
20 protein kinase B signaling GO:0043491 9.82 CCL3 IL1B TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 CCL3 IL1B TNF
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IFNG IL1B IL6 TNF
23 defense response to protozoan GO:0042832 9.79 IFNG IL10 IL6
24 positive regulation of interferon-gamma production GO:0032729 9.78 CCR2 IL1B IL2 TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.77 IFNG IL10 TNF
27 B cell proliferation GO:0042100 9.76 CD40LG CD79A IFNA1 IL10
28 inflammatory response GO:0006954 9.76 CCL3 CCR2 CCR5 CD40LG IL10 IL1B
29 positive regulation of podosome assembly GO:0071803 9.74 CSF2 TNF
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IFNG IL2
31 response to cholesterol GO:0070723 9.73 CCL3 CCR5
32 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
33 cellular response to lipopolysaccharide GO:0071222 9.73 CCR5 CSF2 IFNG IL10 IL6 TNF
34 regulation of defense response to virus by host GO:0050691 9.72 IFNG IL1B
35 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.72 CD4 CSF2
36 signaling GO:0023052 9.72 CCL3 CCR5
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 IFNG IL1B
38 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IFNG IL10
40 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
41 fusion of virus membrane with host plasma membrane GO:0019064 9.7 CCR5 CD4
42 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.7 CCL3 CCR5
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.69 IL6 TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IFNG IL1B TNF
47 positive regulation of interleukin-23 production GO:0032747 9.68 CSF2 IFNG
48 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
49 regulation of immunoglobulin secretion GO:0051023 9.68 CD40LG TNF
50 sequestering of triglyceride GO:0030730 9.67 IL1B TNF

Molecular functions related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL3 CD40LG CSF2 IFNA1 IFNG IL10
2 growth factor activity GO:0008083 9.26 CSF2 IL10 IL2 IL6

Sources for Acquired Immunodeficiency Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN