MCID: ACQ010
MIFTS: 31

Acquired Polycythemia malady

Categories: Genetic diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

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Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 11 13
Secondary Polycythemia 11 66
Secondary Polycythemia Nos 11
 
Polycythemia, Secondary 11
Polycythemia Secondary 48

Classifications:



External Ids:

Disease Ontology11 DOID:2834
ICD1028 D75.1
ICD9CM30 289.0
NCIt43 C27178

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways are G-protein signaling_K-RAS regulation pathway and Hematopoietic cell lineage. Related mouse phenotypes are normal and liver/biliary system.

Related Diseases for Acquired Polycythemia

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Diseases in the Polycythemia family:

Primary Polycythemia acquired polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal recessive secondary polycythemia not associated with vhl gene12.1
2autosomal dominant secondary polycythemia12.1
3erythropoietin polycythemia11.1
4methemoglobinemia10.2EPO, EPOR
5dic in newborn10.2EPO, EPOR
6erythrocytosis, familial, 210.2EPO, EPOR
7budd-chiari syndrome, somatic10.2EPOR, JAK2
8asrar facharzt haque syndrome10.2EPO, EPOR
9classic hodgkin lymphoma, lymphocyte-rich type10.2EPO, JAK2
10transient neonatal neutropenia10.1EPO, EPOR
11basilar artery insufficiency10.1EPO, JAK2
12central nervous system vasculitis10.0EPO, EPOR
13focal epilepsy9.9EPO, JAK2
14peroxisome biogenesis disorder 7a9.9EPO, JAK2
15neurotic disorder9.8EPO, JAK2
16chronic myeloproliferative disease9.8EPO, EPOR, JAK2
17intestinal obstruction9.8EPO, EPOR, JAK2
18thrombocythemia 39.8EPO, EPOR, JAK2
19dilated cardiomyopathy9.8EPO, EPOR, JAK2
20polycythemia9.7
21nephrolithiasis9.6EPO, JAK2
22myelodysplastic syndrome9.6EPO, EPOR, JAK2
23stress polycythemia7.9EPO, EPOR, GYPC, JAK2, SIRPA, SLC2A9

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Hypertension, EssentialPsoriasis Susceptibility 1
Familial Atrial FibrillationRespiratory Failure
Heart DiseasePostinflammatory Pulmonary Fibrosis
Chronic Pulmonary Heart DiseaseBronchitis

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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MGI Mouse Phenotypes related to Acquired Polycythemia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5EPO, EPOR, JAK2, SLC2A9
2MP:00053708.1EPO, EPOR, JAK2, SIRPA, SLC2A9
3MP:00053877.8EPO, EPOR, JAK2, SIRPA, SLC2A9

Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.6EPO, EPOR
29.6EPO, EPOR
39.4JAK2, SIRPA
4
Show member pathways
9.4JAK2, SIRPA
59.4JAK2, SIRPA
69.4JAK2, SIRPA
7
Show member pathways
9.1EPO, EPOR, JAK2
89.1EPO, EPOR, JAK2
9
Show member pathways
9.1EPO, EPOR, JAK2
109.1EPO, EPOR, JAK2
11
Show member pathways
9.1EPO, EPOR, JAK2
12
Show member pathways
9.1EPO, EPOR, JAK2
13
Show member pathways
9.1EPO, EPOR, JAK2
14
Show member pathways
9.1EPO, EPOR, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0EPO, JAK2
2positive regulation of cytosolic calcium ion concentrationGO:00072049.8EPOR, JAK2
3negative regulation of neuron apoptotic processGO:00435249.5EPOR, JAK2
4erythrocyte differentiationGO:00302189.4EPO, JAK2
5positive regulation of neuron projection developmentGO:00109769.3EPO, EPOR
6positive regulation of cell proliferationGO:00082849.1EPO, EPOR, JAK2

Sources for Acquired Polycythemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet