MCID: ACQ010
MIFTS: 31

Acquired Polycythemia malady

Categories: Genetic diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

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Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 11 13
Secondary Polycythemia 11 68
Secondary Polycythemia Nos 11
 
Polycythemia, Secondary 11
Polycythemia Secondary 50

Classifications:



External Ids:

Disease Ontology11 DOID:2834
ICD1030 D75.1
ICD9CM32 289.0
NCIt45 C27178

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways are G-protein signaling_K-RAS regulation pathway and Hematopoietic cell lineage. Related mouse phenotypes are immune system and liver/biliary system.

Related Diseases for Acquired Polycythemia

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Diseases in the Polycythemia family:

Primary Polycythemia acquired polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal recessive secondary polycythemia not associated with vhl gene12.0
2autosomal dominant secondary polycythemia11.9
3erythropoietin polycythemia10.9
4methemoglobinemia10.2EPO, EPOR
5dic in newborn10.2EPO, EPOR
6erythrocytosis, familial, 210.2EPO, EPOR
7budd-chiari syndrome, somatic10.1EPOR, JAK2
8asrar facharzt haque syndrome10.1EPO, EPOR
9classic hodgkin lymphoma, lymphocyte-rich type10.1EPO, JAK2
10transient neonatal neutropenia10.1EPO, EPOR
11basilar artery insufficiency10.1EPO, JAK2
12central nervous system vasculitis10.0EPO, EPOR
13focal epilepsy9.9EPO, JAK2
14peroxisome biogenesis disorder 7a9.9EPO, JAK2
15neurotic disorder9.8EPO, JAK2
16intestinal obstruction9.8EPO, EPOR, JAK2
17thrombocythemia 39.8EPO, EPOR, JAK2
18dilated cardiomyopathy9.8EPO, EPOR, JAK2
19nephrolithiasis9.6EPO, JAK2
20myelodysplastic syndrome9.6EPO, EPOR, JAK2
21polycythemia9.6
22stress polycythemia8.1EPO, EPOR, GYPC, JAK2, SIRPA, SLC2A9

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Hypertension, EssentialPsoriasis Susceptibility 1
Familial Atrial FibrillationRespiratory Failure
Heart DiseasePostinflammatory Pulmonary Fibrosis
Chronic Pulmonary Heart DiseaseBronchitis

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

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Human phenotypes related to Acquired Polycythemia:

 64 (show all 14)
id Description HPO Frequency HPO Source Accession
1 hypertension64 hallmark (90%) HP:0000822
2 acrocyanosis64 hallmark (90%) HP:0001063
3 obesity64 hallmark (90%) HP:0001513
4 abnormality of erythrocytes64 hallmark (90%) HP:0001877
5 migraine64 hallmark (90%) HP:0002076
6 hypotension64 hallmark (90%) HP:0002615
7 cerebral ischemia64 hallmark (90%) HP:0002637
8 reduced consciousness/confusion64 hallmark (90%) HP:0004372
9 thrombophlebitis64 hallmark (90%) HP:0004418
10 arterial thrombosis64 hallmark (90%) HP:0004420
11 gastrointestinal infarctions64 hallmark (90%) HP:0005244
12 venous insufficiency64 hallmark (90%) HP:0005293
13 visceral angiomatosis64 hallmark (90%) HP:0100761
14 clubbing of toes64 typical (50%) HP:0100760

MGI Mouse Phenotypes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.7EPO, EPOR, JAK2, SIRPA, SLC2A9
2MP:00053708.7EPO, EPOR, JAK2, SIRPA, SLC2A9
3MP:00028738.5EPO, EPOR, JAK2, SLC2A9

Drugs & Therapeutics for Acquired Polycythemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary PolycythemiaNot yet recruitingNCT03008642

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.6EPO, EPOR
29.6EPO, EPOR
39.4JAK2, SIRPA
4
Show member pathways
9.4JAK2, SIRPA
59.4JAK2, SIRPA
69.4JAK2, SIRPA
7
Show member pathways
9.1EPO, EPOR, JAK2
8
Show member pathways
9.1EPO, EPOR, JAK2
99.1EPO, EPOR, JAK2
10
Show member pathways
9.1EPO, EPOR, JAK2
11
Show member pathways
9.1EPO, EPOR, JAK2
129.1EPO, EPOR, JAK2
13
Show member pathways
9.1EPO, EPOR, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1erythrocyte differentiationGO:003021810.2EPO, JAK2
2negative regulation of neuron apoptotic processGO:004352410.2EPOR, JAK2
3positive regulation of cytosolic calcium ion concentrationGO:000720410.0EPOR, JAK2
4positive regulation of neuron projection developmentGO:00109769.9EPO, EPOR
5positive regulation of cell proliferationGO:00082849.7EPO, EPOR, JAK2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.5EPO, JAK2

Sources for Acquired Polycythemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet