MCID: ACQ010
MIFTS: 29

Acquired Polycythemia malady

Immune diseases, Blood diseases categories

Summaries for Acquired Polycythemia

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32MalaCards
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MalaCards: Acquired Polycythemia, also known as secondary polycythemia, is related to primary polycythemia and polycythemia. An important gene associated with Acquired Polycythemia is JAK2 (Janus kinase 2), and among its related pathways are Erythropoietin Pathway and PI3K-Akt signaling pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

acquired polycythemia 8
secondary polycythemia 8 60
secondary polycythemia nos 8
polycythemia, secondary 8
polycythemia secondary 44


External Ids:

Disease Ontology8 DOID:2834
NCIt39 C27178
ICD9CM27 289.0
ICD1025 D75.1

Related Diseases for Acquired Polycythemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Clinical Features for Acquired Polycythemia

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Drugs & Therapeutics for Acquired Polycythemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acquired Polycythemia

Search CenterWatch for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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50PubMed
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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Polycythemia vera-associated acquired von Willebrand syndrome despite near-normal platelet count. (20575028)
2010
2
Congenital and acquired polycythemias. (19633771)
2008
3
Switch in X-inactivation in a JAK2 V617F-negative case of polycythemia vera with two acquired X-autosome translocations. (17204324)
2007
4
Identification of an acquired JAK2 mutation in polycythemia vera. (15863514)
2005

Genetic Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Acquired Polycythemia

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pp 100449.4JAK2, EPO
2anagrelide44 1110.4JAK2, EPO
3aminoguanidine44 28 1111.4JAK2, EPO
4hydroxyurea44 49 1111.4EPO, JAK2
5gp 130449.4JAK2, EPO
6imatinib44 49 1111.4JAK2, EPO
75-aza-2deoxycytidine449.3JAK2, EPO
8ascorbic acid44 2410.3EPO, JAK2
9butyrate449.3JAK2, EPO
10rapamycin449.2JAK2, EPO
11ly294002449.2EPO, JAK2
12cyclosporin a44 28 5911.1JAK2, EPO
13aspartate449.1JAK2, EPO
14cisplatin44 49 59 1112.0EPO, JAK2
15thymidine44 249.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

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16Gene Ontology
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Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:0082849.1EPO, JAK2
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.0EPO, JAK2
3response to lipopolysaccharideGO:0324968.8EPO, JAK2

Products for genes affiliated with Acquired Polycythemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Polycythemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet