MCID: ACQ010
MIFTS: 29

Acquired Polycythemia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Acquired Polycythemia

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Sources:
9Disease Ontology, 60UMLS, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 38NCIt, 25ICD10
See all sources

Acquired Polycythemia, Aliases & Descriptions:

Name: Acquired Polycythemia 9
Secondary Polycythemia 9 60
Secondary Polycythemia Nos 9
 
Polycythemia, Secondary 9
Polycythemia Secondary 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:2834
ICD9CM27 289.0
NCIt38 C27178
ICD1025 D75.1

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and leukemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Related Diseases for Acquired Polycythemia

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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1JAK2, EPO
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1JAK2, EPO
4
Show member pathways
9.1JAK2, EPO
5
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling36
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b736
a4b1 and a4b7 Integrin signaling36
9.1JAK2, EPO

Compounds for genes affiliated with Acquired Polycythemia

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Compounds related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100439.5JAK2, EPO
2anagrelide43 1210.4JAK2, EPO
3aminoguanidine43 28 1211.4JAK2, EPO
4hydroxyurea43 49 1211.4JAK2, EPO
5gp 130439.4EPO, JAK2
6imatinib43 49 1211.4JAK2, EPO
75-aza-2deoxycytidine439.4JAK2, EPO
8ascorbic acid43 2410.4EPO, JAK2
9butyrate439.4JAK2, EPO
10rapamycin439.3EPO, JAK2
11ly294002439.3JAK2, EPO
12cyclosporin a43 28 5911.3JAK2, EPO
13thymidine43 2410.2JAK2, EPO
14cisplatin43 49 59 1212.2EPO, JAK2
15aspartate439.1JAK2, EPO
16oxygen43 2410.1JAK2, EPO
17vegf439.0JAK2, EPO
18phosphatidylinositol438.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.2JAK2, EPO
2response to lipopolysaccharideGO:00324969.1JAK2, EPO
3signal transductionGO:00071659.1JAK2, EPO
4positive regulation of cell proliferationGO:00082849.0EPO, JAK2
5apoptotic processGO:00069158.8JAK2, EPO

Products for genes affiliated with Acquired Polycythemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acquired Polycythemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet