MCID: ACQ010
MIFTS: 29

Acquired Polycythemia malady

Genetic diseases (common), Immune diseases, Blood diseases categories

Summaries for Acquired Polycythemia

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and myeloproliferative disorder. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

About this section
Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

acquired polycythemia 9
secondary polycythemia 9 63
secondary polycythemia nos 9
polycythemia, secondary 9
polycythemia secondary 46


External Ids:

Disease Ontology9 DOID:2834
NCIt41 C27178
ICD9CM28 289.0
ICD1026 D75.1

Related Diseases for Acquired Polycythemia

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

About this section

Drugs & Therapeutics for Acquired Polycythemia

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acquired Polycythemia

Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Search CenterWatch for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

About this section

Anatomical Context for Acquired Polycythemia

About this section

Animal Models for Acquired Polycythemia or affiliated genes

About this section

Publications for Acquired Polycythemia

About this section
Sources:
53PubMed
See all sources

Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

About this section

Expression for genes affiliated with Acquired Polycythemia

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

About this section
Sources:
51PathCards, 31KEGG, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database
See all sources

Pathways related to Acquired Polycythemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1EPO, JAK2
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1EPO, JAK2
4
Show member pathways
9.1EPO, JAK2
5
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling39
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b739
a4b1 and a4b7 Integrin signaling39
9.1EPO, JAK2

Compounds for genes affiliated with Acquired Polycythemia

About this section
Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
See all sources

Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100469.5JAK2, EPO
2anagrelide46 1210.4JAK2, EPO
3aminoguanidine46 30 1211.4JAK2, EPO
4hydroxyurea46 52 1211.4JAK2, EPO
5gp 130469.4EPO, JAK2
6imatinib46 52 1211.4JAK2, EPO
75-aza-2deoxycytidine469.4JAK2, EPO
8ascorbic acid46 2510.4EPO, JAK2
9butyrate469.4JAK2, EPO
10rapamycin469.3EPO, JAK2
11ly294002469.3JAK2, EPO
12cyclosporin a46 30 6211.3JAK2, EPO
13thymidine46 2510.2JAK2, EPO
14cisplatin46 52 62 1212.2EPO, JAK2
15aspartate469.1JAK2, EPO
16oxygen46 2510.1JAK2, EPO
17vegf469.0JAK2, EPO
18phosphatidylinositol468.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2EPO, JAK2
2response to lipopolysaccharideGO:0324969.1EPO, JAK2
3signal transductionGO:0071659.1EPO, JAK2
4positive regulation of cell proliferationGO:0082849.0EPO, JAK2
5apoptotic processGO:0069158.8EPO, JAK2

Products for genes affiliated with Acquired Polycythemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Polycythemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet