MCID: ACQ010
MIFTS: 35

Acquired Polycythemia malady

Categories: Genetic diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

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Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 10 12
Secondary Polycythemia 10 65
Secondary Polycythemia Nos 10
 
Polycythemia, Secondary 10
Polycythemia Secondary 47

Classifications:



External Ids:

Disease Ontology10 DOID:2834
ICD1027 D75.1
ICD9CM29 289.0
NCIt42 C27178
UMLS65 C1318533

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways are G-protein signaling_K-RAS regulation pathway and Hematopoietic cell lineage. Affiliated tissues include b cells, prostate and breast, and related mouse phenotypes are normal and liver/biliary system.

Related Diseases for Acquired Polycythemia

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Diseases in the Polycythemia family:

Primary Polycythemia acquired polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal recessive secondary polycythemia not associated with vhl gene12.1
2autosomal dominant secondary polycythemia12.1
3erythropoietin polycythemia11.1
4arthritis10.3EPO, EPOR
5erythrocytosis, familial, 210.3EPO, EPOR
6transient neonatal neutropenia10.3EPO, EPOR
7neonatal anemia10.3EPO, EPOR
8budd-chiari syndrome, somatic10.2EPOR, JAK2
9classic hodgkin lymphoma, mixed cellularity type10.2EPO, JAK2
10thrombocytosis10.2EPO, JAK2
11megakaryocytic tumor10.2EPO, JAK2
12split hand foot malformation10.1EPO, JAK2
13basilar artery insufficiency10.0EPO, JAK2
14thbd-related atypical hemolytic-uremic syndrome9.9EPO, HBB
15neonatal stroke9.9EPO, JAK2
16pulmonary alveolar proteinosis9.9EPO, HBB
17malignant adult ependymoma9.9EPO, HBB
18mesenteric lymphadenitis9.9EPO, EPOR, JAK2
19thrombocythemia 39.9EPO, EPOR, JAK2
20congenital nonspherocytic hemolytic anemia9.8EPO, HBB
21pericardial tuberculosis9.8EPO, EPOR, JAK2
22diffuse large b-cell lymphoma9.8EPO, EPOR, JAK2
23snyder-robinson syndrome9.8EPO, HBB
24thalassemia-beta, dominant inclusion-body9.8EPO, HBB
25myelodysplastic syndrome9.7EPO, EPOR, JAK2
26polycythemia9.7
27sickle cell anemia9.6EPO, HBB
28agammaglobulinemia 29.6EPO, JAK2
29thromboangiitis obliterans9.6EPO, HBB
30tendinitis9.5EPO, EPOR, HBB
31acute kidney failure9.1EPO, EPOR, HBB, JAK2
32thyroid malformation9.1EPO, EPOR, HBB, JAK2
33polycythemia due to hypoxia8.0EPO, EPOR, HBB, JAK2, SIRPA, SLC2A9

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


BronchitisChronic Pulmonary Heart Disease
Familial Atrial FibrillationHeart Disease
Hypertension, EssentialPostinflammatory Pulmonary Fibrosis
Respiratory FailurePsoriasis Susceptibility 1

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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MalaCards organs/tissues related to Acquired Polycythemia:

33
B cells, Prostate, Breast, Thyroid, Kidney

Animal Models for Acquired Polycythemia or affiliated genes

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MGI Mouse Phenotypes related to Acquired Polycythemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5EPO, EPOR, JAK2, SLC2A9
2MP:00053707.8EPO, EPOR, JAK2, SIRPA, SLC2A9

Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.6EPO, EPOR
29.6EPO, EPOR
3
Show member pathways
9.4JAK2, SIRPA
49.4JAK2, SIRPA
5
Show member pathways
9.1EPO, EPOR, JAK2
6
Show member pathways
9.1EPO, EPOR, JAK2
79.1EPO, EPOR, JAK2
8
Show member pathways
9.1EPO, EPOR, JAK2
99.1EPO, EPOR, JAK2
10
Show member pathways
9.1EPO, EPOR, JAK2
11
Show member pathways
9.1EPO, EPOR, JAK2
12
Show member pathways
9.1EPO, EPOR, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8EPO, JAK2
2positive regulation of cytosolic calcium ion concentrationGO:00072049.5EPOR, JAK2
3positive regulation of neuron projection developmentGO:00109769.3EPO, EPOR

Sources for Acquired Polycythemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet