MCID: ACQ010
MIFTS: 30

Acquired Polycythemia malady

Categories: Genetic diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

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Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 11 13
Secondary Polycythemia 11 68
Secondary Polycythemia Nos 11
 
Polycythemia, Secondary 11
Polycythemia Secondary 50

Classifications:



External Ids:

Disease Ontology11 DOID:2834
ICD1030 D75.1
ICD9CM32 289.0
NCIt45 C27178

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including hypertension, acrocyanosis and clubbing. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways are Hematopoietic cell lineage and G-protein signaling_K-RAS regulation pathway. Related mouse phenotypes are immune system and liver/biliary system.

Related Diseases for Acquired Polycythemia

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Diseases in the Polycythemia family:

Primary Polycythemia acquired polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal recessive secondary polycythemia not associated with vhl gene12.0
2autosomal dominant secondary polycythemia11.9
3erythropoietin polycythemia11.0
4pyloric stenosis, infantile hypertrophic, 410.1EPO, JAK2
5spondylocostal dysostosis 210.1EPO, JAK2
6von hippel anomaly10.1EPO, JAK2
7atrioventricular septal defect 210.1EPO, EPOR
8disseminated intravascular coagulation10.1EPO, EPOR
9extranodal nasal nk/t cell lymphoma10.0EPO, EPOR
10dic in newborn10.0EPO, EPOR
11membranoproliferative glomerulonephritis10.0EPO, JAK2
12granular cell leiomyosarcoma10.0EPO, EPOR
13granulomatous hepatitis10.0EPO, JAK2
14queensland tick typhus10.0EPO, EPOR, JAK2
15cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 19.9EPO, EPOR, JAK2
16acute liver failure9.9EPO, EPOR, JAK2
17intestinal impaction9.9EPO, EPOR, JAK2
18erythrocytosis, somatic9.9EPO, EPOR, JAK2
19actinobacillosis9.9EPO, EPOR, JAK2
20basilar artery insufficiency9.9EPO, EPOR, JAK2
21drug-induced hepatitis9.9EPO, EPOR, JAK2
22neuromyelitis optica9.9EPO, JAK2
23leukemia, acute myeloid9.9EPO, EPOR, JAK2
24polycythemia9.6
25long qt syndrome9.2EPO, EPOR, GYPC, JAK2, SIRPA, SLC2A9

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


BronchitisChronic Pulmonary Heart Disease
Familial Atrial FibrillationHeart Disease
Hypertension, EssentialPostinflammatory Pulmonary Fibrosis
Respiratory FailurePrimary Polycythemia

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

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Human phenotypes related to Acquired Polycythemia:

 64 (show all 15)
id Description HPO Frequency HPO Source Accession
1 hypertension64 HP:0000822
2 acrocyanosis64 HP:0001063
3 clubbing64 HP:0001217
4 lethargy64 HP:0001254
5 stroke64 HP:0001297
6 obesity64 HP:0001513
7 abnormality of leukocytes64 HP:0001881
8 headache64 HP:0002315
9 hypotension64 HP:0002615
10 arterial thrombosis64 HP:0004420
11 venous thrombosis64 HP:0004936
12 gastrointestinal infarctions64 HP:0005244
13 venous insufficiency64 HP:0005293
14 erythema64 HP:0010783
15 visceral angiomatosis64 HP:0100761

MGI Mouse Phenotypes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.7EPO, EPOR, JAK2, SIRPA, SLC2A9
2MP:00053707.9EPO, EPOR, JAK2, SIRPA, SLC2A9

Drugs & Therapeutics for Acquired Polycythemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary PolycythemiaNot yet recruitingNCT03008642

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.6EPO, EPOR
29.6EPO, EPOR
39.4JAK2, SIRPA
49.4JAK2, SIRPA
59.1EPO, EPOR, JAK2
6
Show member pathways
9.1EPO, EPOR, JAK2
7
Show member pathways
9.1EPO, EPOR, JAK2
89.1EPO, EPOR, JAK2
9
Show member pathways
9.1EPO, EPOR, JAK2
10
Show member pathways
9.1EPO, EPOR, JAK2
11
Show member pathways
9.1EPO, EPOR, JAK2
12
Show member pathways
9.1EPO, EPOR, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1erythropoietin-mediated signaling pathwayGO:003816210.1EPO, EPOR
2erythrocyte differentiationGO:003021810.0EPO, JAK2
3positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.9EPO, JAK2
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.5EPO, JAK2

Sources for Acquired Polycythemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet