MCID: ACQ010
MIFTS: 33

Acquired Polycythemia

Categories: Immune diseases, Blood diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Acquired Polycythemia

Summaries for Acquired Polycythemia

MalaCards based summary : Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and autosomal recessive secondary polycythemia not associated with vhl gene, and has symptoms including hypertension, acrocyanosis and clubbing. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Related phenotypes are immune system and liver/biliary system

Related Diseases for Acquired Polycythemia

Diseases in the Polycythemia family:

Primary Polycythemia Acquired Polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 polycythemia 29.2 EPO EPOR JAK2
2 autosomal recessive secondary polycythemia not associated with vhl gene 12.1
3 autosomal dominant secondary polycythemia 12.1
4 erythropoietin polycythemia 11.1
5 erythrocytosis, familial, 2 10.1 EPO EPOR
6 neonatal anemia 10.1 EPO EPOR
7 retinitis pigmentosa and erythrocytic microcytosis 10.1 EPO JAK2
8 ewing's family of tumors 10.1 EPO EPOR
9 anemia of prematurity 10.1 EPO EPOR
10 splenomegaly 10.1 EPO JAK2
11 refractory anemia 10.1 EPO JAK2
12 hemangioblastoma 10.0 EPO EPOR
13 thrombocytosis 9.9 EPO JAK2
14 immune system disease 9.9 EPO JAK2
15 deficiency anemia 9.9 EPO EPOR
16 primary polycythemia 9.8 EPO EPOR JAK2
17 acute erythroid leukemia 9.8 EPO EPOR JAK2
18 erythrocytosis, familial, 1 9.8 EPO EPOR JAK2
19 bone marrow cancer 9.8 EPO EPOR JAK2
20 polycythemia vera 9.8 EPO EPOR JAK2
21 essential thrombocythemia 9.8 EPO EPOR JAK2
22 diamond-blackfan anemia 9.8 EPO EPOR JAK2
23 leukemia, chronic myeloid 9.7 EPO JAK2
24 myelodysplastic syndrome 9.7 EPO EPOR JAK2

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to Acquired Polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

Human phenotypes related to Acquired Polycythemia:

31 (show all 15)
# Description HPO Frequency HPO Source Accession
1 hypertension 31 hallmark (90%) HP:0000822
2 acrocyanosis 31 hallmark (90%) HP:0001063
3 clubbing 31 frequent (33%) HP:0001217
4 lethargy 31 hallmark (90%) HP:0001254
5 stroke 31 hallmark (90%) HP:0001297
6 obesity 31 hallmark (90%) HP:0001513
7 abnormal leukocyte morphology 31 hallmark (90%) HP:0001881
8 headache 31 hallmark (90%) HP:0002315
9 hypotension 31 hallmark (90%) HP:0002615
10 arterial thrombosis 31 hallmark (90%) HP:0004420
11 venous thrombosis 31 hallmark (90%) HP:0004936
12 gastrointestinal infarctions 31 hallmark (90%) HP:0005244
13 venous insufficiency 31 hallmark (90%) HP:0005293
14 erythema 31 hallmark (90%) HP:0010783
15 visceral angiomatosis 31 hallmark (90%) HP:0100761

MGI Mouse Phenotypes related to Acquired Polycythemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.35 EPO EPOR JAK2 SIRPA SLC2A9
2 liver/biliary system MP:0005370 9.02 EPO EPOR JAK2 SIRPA SLC2A9

Drugs & Therapeutics for Acquired Polycythemia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia Not yet recruiting NCT03008642

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

Anatomical Context for Acquired Polycythemia

Publications for Acquired Polycythemia

Articles related to Acquired Polycythemia:

# Title Authors Year
1
Congenital and acquired polycythemias. ( 19633771 )
2008

Variations for Acquired Polycythemia

Expression for Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for Acquired Polycythemia

Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 EPO EPOR JAK2
2 12.36 EPO EPOR JAK2
3
Show member pathways
12.34 EPO EPOR JAK2
4
Show member pathways
12.31 EPO EPOR JAK2
5
Show member pathways
11.88 EPO EPOR JAK2
6 11.69 JAK2 SIRPA
7
Show member pathways
11.64 EPO EPOR JAK2
8
Show member pathways
11.54 JAK2 SIRPA
9 11.46 EPO EPOR
10 11.24 EPO EPOR JAK2
11
Show member pathways
11.12 EPO EPOR JAK2
12 10.86 JAK2 SIRPA
13 10.8 EPO EPOR
14
Show member pathways
10.44 EPO EPOR JAK2

GO Terms for Acquired Polycythemia

Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 EPO JAK2
2 erythrocyte differentiation GO:0030218 8.96 EPO JAK2
3 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Acquired Polycythemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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