MCID: ACQ010
MIFTS: 29

Acquired Polycythemia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Acquired Polycythemia

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Sources:
8Disease Ontology, 61UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 8
Secondary Polycythemia 8 61
Secondary Polycythemia Nos 8
 
Polycythemia, Secondary 8
Polycythemia Secondary 44


Classifications:



External Ids:

Disease Ontology8 DOID:2834
ICD9CM27 289.0
NCIt39 C27178
ICD1025 D75.1

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and leukemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Related Diseases for Acquired Polycythemia

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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1JAK2, EPO
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1JAK2, EPO
4
Show member pathways
9.1JAK2, EPO
5
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling36
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b736
a4b1 and a4b7 Integrin signaling36
9.1JAK2, EPO

Compounds for genes affiliated with Acquired Polycythemia

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Compounds related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100449.5JAK2, EPO
2anagrelide44 1110.4JAK2, EPO
3aminoguanidine44 28 1111.4JAK2, EPO
4hydroxyurea44 50 1111.4JAK2, EPO
5gp 130449.4EPO, JAK2
6imatinib44 50 1111.4JAK2, EPO
75-aza-2deoxycytidine449.4JAK2, EPO
8ascorbic acid44 2410.4EPO, JAK2
9butyrate449.4JAK2, EPO
10rapamycin449.3EPO, JAK2
11ly294002449.3JAK2, EPO
12cyclosporin a44 28 6011.3JAK2, EPO
13thymidine44 2410.2JAK2, EPO
14cisplatin44 50 60 1112.2EPO, JAK2
15aspartate449.1JAK2, EPO
16oxygen44 2410.1JAK2, EPO
17vegf449.0JAK2, EPO
18phosphatidylinositol448.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.2JAK2, EPO
2response to lipopolysaccharideGO:00324969.1JAK2, EPO
3signal transductionGO:00071659.1JAK2, EPO
4positive regulation of cell proliferationGO:00082849.0EPO, JAK2
5apoptotic processGO:00069158.8JAK2, EPO

Sources for Acquired Polycythemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet