MCID: ACQ010
MIFTS: 34

Acquired Polycythemia malady

Genetic diseases (common), Blood diseases, Immune diseases categories

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and leukemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

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Sources:
9Disease Ontology, 61UMLS, 44Novoseek, 39NCIt, 28ICD9CM, 56SNOMED-CT
See all sources

Acquired Polycythemia, Aliases & Descriptions:

Name: Acquired Polycythemia 9
Secondary Polycythemia 9 61
Secondary Polycythemia Nos 9
 
Polycythemia, Secondary 9
Polycythemia Secondary 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Blood diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:2834
NCIt39 C27178
ICD9CM28 289.0

Related Diseases for Acquired Polycythemia

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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Expression patterns in normal tissues for genes affiliated with Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1JAK2, EPO
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1JAK2, EPO
4
Show member pathways
9.1JAK2, EPO
5
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling37
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b737
a4b1 and a4b7 Integrin signaling37
9.1JAK2, EPO

Compounds for genes affiliated with Acquired Polycythemia

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Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100449.5EPO, JAK2
2anagrelide44 1210.4EPO, JAK2
3aminoguanidine44 29 1211.4JAK2, EPO
4hydroxyurea44 50 1211.4EPO, JAK2
5gp 130449.4EPO, JAK2
6imatinib44 50 1211.4EPO, JAK2
75-aza-2deoxycytidine449.4JAK2, EPO
8ascorbic acid44 2510.4EPO, JAK2
9butyrate449.4EPO, JAK2
10rapamycin449.3EPO, JAK2
11ly294002449.3JAK2, EPO
12cyclosporin a44 29 6011.3EPO, JAK2
13thymidine44 2510.2JAK2, EPO
14cisplatin44 50 60 1212.2JAK2, EPO
15aspartate449.1EPO, JAK2
16oxygen44 2510.1EPO, JAK2
17vegf449.0EPO, JAK2
18phosphatidylinositol448.8EPO, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2EPO, JAK2
2response to lipopolysaccharideGO:0324969.1EPO, JAK2
3signal transductionGO:0071659.1EPO, JAK2
4positive regulation of cell proliferationGO:0082849.0EPO, JAK2
5apoptotic processGO:0069158.8EPO, JAK2

Products for genes affiliated with Acquired Polycythemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acquired Polycythemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet