MCID: ACQ010
MIFTS: 31

Acquired Polycythemia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Acquired Polycythemia

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Sources:
10Disease Ontology, 12DISEASES, 65UMLS, 47Novoseek, 59SNOMED-CT, 42NCIt, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 10 12
Secondary Polycythemia 10 65
Secondary Polycythemia Nos 10
 
Polycythemia, Secondary 10
Polycythemia Secondary 47


Classifications:



External Ids:

Disease Ontology10 DOID:2834
NCIt42 C27178
ICD9CM29 289.0
ICD1027 D75.1

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways are Hematopoietic cell lineage and G-protein signaling_K-RAS regulation pathway. Related mouse phenotypes are normal and embryogenesis.

Related Diseases for Acquired Polycythemia

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Diseases in the Polycythemia family:

Polycythemia Due to Hypoxia Primary Polycythemia
acquired polycythemia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal recessive secondary polycythemia not associated with vhl gene10.3
2autosomal dominant secondary polycythemia10.3
3neonatal diabetes mellitus10.1EPO, EPOR
4exencephaly10.1EPO, EPOR
5thbd-related atypical hemolytic-uremic syndrome10.1EPO, HBB
6posterior uveitis10.1EPO, EPOR
7hepatic encephalopathy10.1EPO, HBB
8erythrocytosis, somatic10.1EPOR, JAK2
9split cord malformation10.1EPO, JAK2
10classic hodgkin lymphoma, mixed cellularity type10.1EPO, JAK2
11platelet storage pool deficiency10.1EPO, JAK2
12adamantinous craniopharyngioma10.1HBB, JAK2
13hemoglobinuria10.1EPO, HBB
14hemangioma of intra-abdominal structure10.1EPO, EPOR
15polycythemia10.1
16snyder-robinson syndrome10.1EPO, HBB
17avoidant personality disorder10.0HBB, JAK2
18trigeminal neuralgia10.0EPO, JAK2
19hemangioma10.0
20hepatitis10.0
21leukemia10.0
22hydronephrosis10.0
23erythropoietin polycythemia10.0
24hemangioblastoma10.0
25obstructive lung disease10.0
26pulmonary embolism10.0
27respiratory failure10.0
28hypoxia10.0
29endotheliitis10.0
30multiloculated renal cyst10.0
31sickle cell anemia10.0EPO, HBB
32ewing's family of tumors10.0EPO, JAK2
33agammaglobulinemia 210.0EPO, JAK2
34congenital hypoplastic anemia10.0EPO, HBB
35mesenteric lymphadenitis9.9EPO, EPOR, JAK2
36polycythemia vera, somatic9.9EPO, EPOR, JAK2
37bone osteosarcoma9.9EPO, EPOR, JAK2
38thalassemia, hispanic gamma-delta-beta9.9EPO, HBB
39tendinitis9.9EPO, EPOR, HBB
40myelodysplastic syndrome9.9EPO, EPOR, JAK2
41thromboangiitis obliterans9.9EPO, HBB
42acute kidney failure9.7EPO, EPOR, HBB, JAK2
43polyneuropathy9.7EPO, EPOR, HBB, JAK2
44acrocephalosyndactylia9.2EPO, EPOR, HBB, JAK2, SIRPA, SLC2A9

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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MGI Mouse Phenotypes related to Acquired Polycythemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9EPO, EPOR, HBB, JAK2
2MP:00053808.7EPO, EPOR, HBB, JAK2
3MP:00053708.5EPO, EPOR, HBB, SIRPA
4MP:00053767.8EPO, EPOR, HBB, JAK2, SLC2A9
5MP:00053977.7EPO, EPOR, HBB, JAK2, SIRPA
6MP:00053787.6EPOR, HBB, JAK2, SIRPA, SLC2A9
7MP:00053877.2EPOR, HBB, JAK2, SIRPA, SLC2A9

Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EPO, EPOR
29.6EPO, EPOR
3
Show member pathways
9.1JAK2, SIRPA
49.1JAK2, SIRPA
5
Show member pathways
9.1EPO, EPOR, JAK2
6
Show member pathways
9.1EPO, EPOR, JAK2
7
Show member pathways
9.1EPO, EPOR, JAK2
89.1EPO, EPOR, JAK2
9
Show member pathways
9.1EPO, EPOR, JAK2
10
Show member pathways
9.1EPO, EPOR, JAK2
11
Show member pathways
9.1EPO, EPOR, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1EPO, JAK2
2erythrocyte differentiationGO:003021810.0EPO, JAK2
3positive regulation of cytosolic calcium ion concentrationGO:00072049.8EPOR, JAK2
4negative regulation of neuron apoptotic processGO:00435249.7EPOR, JAK2
5positive regulation of nitric oxide biosynthetic processGO:00454299.7HBB, JAK2
6blood coagulationGO:00075968.6HBB, JAK2, SIRPA

Molecular functions related to Acquired Polycythemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.4HBB, JAK2

Sources for Acquired Polycythemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet