MCID: ACQ010
MIFTS: 29

Acquired Polycythemia malady

Genetic diseases (common), Immune diseases, Blood diseases categories
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Summaries for Acquired Polycythemia

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33MalaCards
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MalaCards: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and myeloproliferative disorder. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

acquired polycythemia 8
secondary polycythemia 8 62
secondary polycythemia nos 8
polycythemia, secondary 8
polycythemia secondary 45


External Ids:

Disease Ontology8 DOID:2834
NCIt40 C27178
ICD9CM27 289.0
ICD1025 D75.1

Related Diseases for Acquired Polycythemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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Drugs & Therapeutics for Acquired Polycythemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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52PubMed
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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Acquired Polycythemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1EPO, JAK2
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1EPO, JAK2
4
Show member pathways
9.1EPO, JAK2
5
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling38
EPO signaling pathway38
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling38
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b738
a4b1 and a4b7 Integrin signaling38
9.1EPO, JAK2

Compounds for genes affiliated with Acquired Polycythemia

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100459.5JAK2, EPO
2anagrelide45 1110.4JAK2, EPO
3aminoguanidine45 29 1111.4JAK2, EPO
4hydroxyurea45 51 1111.4JAK2, EPO
5gp 130459.4EPO, JAK2
6imatinib45 51 1111.4JAK2, EPO
75-aza-2deoxycytidine459.4JAK2, EPO
8ascorbic acid45 2410.4EPO, JAK2
9butyrate459.4JAK2, EPO
10rapamycin459.3EPO, JAK2
11ly294002459.3JAK2, EPO
12cyclosporin a45 29 6111.3JAK2, EPO
13thymidine45 2410.2JAK2, EPO
14cisplatin45 51 61 1112.2EPO, JAK2
15aspartate459.1JAK2, EPO
16oxygen45 2410.1JAK2, EPO
17vegf459.0JAK2, EPO
18phosphatidylinositol458.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

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16Gene Ontology
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Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2EPO, JAK2
2response to lipopolysaccharideGO:0324969.1EPO, JAK2
3signal transductionGO:0071659.1EPO, JAK2
4positive regulation of cell proliferationGO:0082849.0EPO, JAK2
5apoptotic processGO:0069158.8EPO, JAK2

Products for genes affiliated with Acquired Polycythemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Polycythemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet