MCID: ACQ010
MIFTS: 34

Acquired Polycythemia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Summaries for Acquired Polycythemia

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MalaCards based summary: Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and leukemia, and has symptoms including hypertension, acrocyanosis and obesity. An important gene associated with Acquired Polycythemia is EPO (erythropoietin), and among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

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Sources:
10Disease Ontology, 62UMLS, 45Novoseek, 57SNOMED-CT, 29ICD9CM, 40NCIt
See all sources

Acquired Polycythemia, Aliases & Descriptions:

Name: Acquired Polycythemia 10
Secondary Polycythemia 10 62
Secondary Polycythemia Nos 10
 
Polycythemia, Secondary 10
Polycythemia Secondary 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology10 DOID:2834
ICD9CM29 289.0
NCIt40 C27178

Related Diseases for Acquired Polycythemia

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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Symptoms for Acquired Polycythemia

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HPO human phenotypes related to Acquired Polycythemia:

(show all 14)
id Description Frequency HPO Source Accession
1 hypertension hallmark (90%) HP:0000822
2 acrocyanosis hallmark (90%) HP:0001063
3 obesity hallmark (90%) HP:0001513
4 abnormality of erythrocytes hallmark (90%) HP:0001877
5 migraine hallmark (90%) HP:0002076
6 hypotension hallmark (90%) HP:0002615
7 cerebral ischemia hallmark (90%) HP:0002637
8 reduced consciousness/confusion hallmark (90%) HP:0004372
9 thrombophlebitis hallmark (90%) HP:0004418
10 arterial thrombosis hallmark (90%) HP:0004420
11 gastrointestinal infarctions hallmark (90%) HP:0005244
12 venous insufficiency hallmark (90%) HP:0005293
13 visceral angiomatosis hallmark (90%) HP:0100761
14 clubbing of toes typical (50%) HP:0100760

Drugs & Therapeutics for Acquired Polycythemia

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Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

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Anatomical Context for Acquired Polycythemia

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Animal Models for Acquired Polycythemia or affiliated genes

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Publications for Acquired Polycythemia

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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Congenital and acquired polycythemias. (19633771)
2008

Variations for Acquired Polycythemia

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Expression for genes affiliated with Acquired Polycythemia

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Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

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Pathways related to Acquired Polycythemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1JAK2, EPO
2
Show member pathways
9.1JAK2, EPO
3
Show member pathways
9.1JAK2, EPO
4
Show member pathways
9.1JAK2, EPO
5
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.1EPO, JAK2
6
Show member pathways
EPO Receptor Signaling38
EPO signaling pathway38
9.1JAK2, EPO
7
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.1JAK2, EPO
8
Show member pathways
Type III interferon signaling38
9.1JAK2, EPO
9
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b738
a4b1 and a4b7 Integrin signaling38
9.1JAK2, EPO

Compounds for genes affiliated with Acquired Polycythemia

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Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1pp 100459.5JAK2, EPO
2anagrelide45 1310.4JAK2, EPO
3aminoguanidine45 30 1311.4JAK2, EPO
4hydroxyurea45 51 1311.4JAK2, EPO
5gp 130459.4EPO, JAK2
6imatinib45 51 1311.4JAK2, EPO
75-aza-2deoxycytidine459.4JAK2, EPO
8ascorbic acid45 2610.4EPO, JAK2
9butyrate459.4JAK2, EPO
10rapamycin459.3EPO, JAK2
11ly294002459.3JAK2, EPO
12cyclosporin a45 30 6111.3JAK2, EPO
13thymidine45 2610.2JAK2, EPO
14cisplatin45 51 61 1312.2EPO, JAK2
15aspartate459.1JAK2, EPO
16oxygen45 2610.1JAK2, EPO
17vegf459.0JAK2, EPO
18phosphatidylinositol458.8JAK2, EPO

GO Terms for genes affiliated with Acquired Polycythemia

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Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.2JAK2, EPO
2response to lipopolysaccharideGO:00324969.1JAK2, EPO
3signal transductionGO:00071659.1JAK2, EPO
4positive regulation of cell proliferationGO:00082849.0EPO, JAK2
5apoptotic processGO:00069158.8JAK2, EPO

Products for genes affiliated with Acquired Polycythemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acquired Polycythemia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet