MCID: ACQ010
MIFTS: 30

Acquired Polycythemia malady

Categories: Immune diseases, Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

Aliases & Descriptions for Acquired Polycythemia:

Name: Acquired Polycythemia 12 14
Secondary Polycythemia 12 69
Secondary Polycythemia Nos 12
Polycythemia, Secondary 12
Polycythemia Secondary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:2834
ICD10 33 D75.1
ICD9CM 35 289.0
NCIt 47 C27178
UMLS 69 C1318533

Summaries for Acquired Polycythemia

MalaCards based summary : Acquired Polycythemia, also known as secondary polycythemia, is related to autosomal recessive secondary polycythemia not associated with vhl gene and autosomal dominant secondary polycythemia, and has symptoms including headache, lethargy and clubbing. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Beta-Adrenergic Signaling. Related phenotypes are immune system and liver/biliary system

Related Diseases for Acquired Polycythemia

Diseases in the Polycythemia family:

Primary Polycythemia Acquired Polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
id Related Disease Score Top Affiliating Genes
1 autosomal recessive secondary polycythemia not associated with vhl gene 12.0
2 autosomal dominant secondary polycythemia 11.9
3 erythropoietin polycythemia 11.0
4 pyloric stenosis, infantile hypertrophic, 4 10.1 EPO JAK2
5 spondylocostal dysostosis 2 10.1 EPO JAK2
6 von hippel anomaly 10.1 EPO JAK2
7 atrioventricular septal defect 2 10.1 EPO EPOR
8 disseminated intravascular coagulation 10.1 EPO EPOR
9 extranodal nasal nk/t cell lymphoma 10.0 EPO EPOR
10 dic in newborn 10.0 EPO EPOR
11 membranoproliferative glomerulonephritis 10.0 EPO JAK2
12 granular cell leiomyosarcoma 10.0 EPO EPOR
13 granulomatous hepatitis 10.0 EPO JAK2
14 queensland tick typhus 10.0 EPO EPOR JAK2
15 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 9.9 EPO EPOR JAK2
16 acute liver failure 9.9 EPO EPOR JAK2
17 intestinal impaction 9.9 EPO EPOR JAK2
18 erythrocytosis, somatic 9.9 EPO EPOR JAK2
19 actinobacillosis 9.9 EPO EPOR JAK2
20 basilar artery insufficiency 9.9 EPO EPOR JAK2
21 drug-induced hepatitis 9.9 EPO EPOR JAK2
22 neuromyelitis optica 9.9 EPO JAK2
23 leukemia, acute myeloid 9.9 EPO EPOR JAK2
24 polycythemia 9.6
25 long qt syndrome 9.2 EPO EPOR GYPC JAK2 SIRPA SLC2A9

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to Acquired Polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

Human phenotypes related to Acquired Polycythemia:

32 (show all 15)
id Description HPO Frequency HPO Source Accession
1 headache 32 HP:0002315
2 lethargy 32 HP:0001254
3 clubbing 32 HP:0001217
4 obesity 32 HP:0001513
5 hypertension 32 HP:0000822
6 hypotension 32 HP:0002615
7 acrocyanosis 32 HP:0001063
8 venous thrombosis 32 HP:0004936
9 visceral angiomatosis 32 HP:0100761
10 erythema 32 HP:0010783
11 stroke 32 HP:0001297
12 arterial thrombosis 32 HP:0004420
13 venous insufficiency 32 HP:0005293
14 gastrointestinal infarctions 32 HP:0005244
15 abnormality of leukocytes 32 HP:0001881

MGI Mouse Phenotypes related to Acquired Polycythemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.35 EPO EPOR JAK2 SIRPA SLC2A9
2 liver/biliary system MP:0005370 9.02 EPO EPOR JAK2 SIRPA SLC2A9

Drugs & Therapeutics for Acquired Polycythemia

Interventional clinical trials:


id Name Status NCT ID Phase
1 CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia Not yet recruiting NCT03008642

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

Anatomical Context for Acquired Polycythemia

Publications for Acquired Polycythemia

Articles related to Acquired Polycythemia:

id Title Authors Year
1
Congenital and acquired polycythemias. ( 19633771 )
2008

Variations for Acquired Polycythemia

Expression for Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for Acquired Polycythemia

Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 EPO EPOR JAK2
2
Show member pathways
12.31 EPO EPOR JAK2
3 12.11 EPO EPOR JAK2
4
Show member pathways
11.74 EPO EPOR JAK2
5 11.66 JAK2 SIRPA
6
Show member pathways
11.64 EPO EPOR JAK2
7 11.44 EPO EPOR
8
Show member pathways
11.32 EPO EPOR JAK2
9 10.96 EPO EPOR JAK2
10 10.86 JAK2 SIRPA
11 10.8 EPO EPOR
12
Show member pathways
10.44 EPO EPOR JAK2

GO Terms for Acquired Polycythemia

Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 EPO JAK2
2 erythrocyte differentiation GO:0030218 9.16 EPO JAK2
3 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 8.96 EPO JAK2
4 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Acquired Polycythemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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