MCID: ACQ010
MIFTS: 25

Acquired Polycythemia malady

Immune, Blood categories

Summaries for Acquired Polycythemia

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33MalaCards
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MalaCards: Acquired Polycythemia, also known as secondary polycythemia, is related to primary polycythemia and myeloproliferative disorder. An important gene associated with Acquired Polycythemia is JAK2 (Janus kinase 2), and among its related pathways are Erythropoietin Pathway and PI3K-Akt signaling pathway. The compounds pp 100 and anagrelide have been mentioned in the context of this disorder.

Aliases & Classifications for Acquired Polycythemia

Sources:
8Disease Ontology, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

acquired polycythemia 8 31
secondary polycythemia 8 61
secondary polycythemia nos 8
polycythemia, secondary 8
polycythemia secondary 45


External Ids:

Disease Ontology8 DOID:2834
NCIt40 C27178
ICD9CM27 289.0
ICD1025 D75.1

Related Diseases for Acquired Polycythemia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to acquired polycythemia

Clinical Features for Acquired Polycythemia

Drugs & Therapeutics for Acquired Polycythemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Acquired Polycythemia

Drug clinical trials:

Search ClinicalTrials for Acquired Polycythemia

Search NIH Clinical Center for Acquired Polycythemia

Search CenterWatch for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

Anatomical Context for Acquired Polycythemia

Animal Models for Acquired Polycythemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Acquired Polycythemia

Sources:
51PubMed
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Articles related to Acquired Polycythemia:

idTitleAuthorsYear
1
Polycythemia vera-associated acquired von Willebrand syndrome despite near-normal platelet count. (20575028)
2010
2
Congenital and acquired polycythemias. (19633771)
2008
3
Switch in X-inactivation in a JAK2 V617F-negative case of polycythemia vera with two acquired X-autosome translocations. (17204324)
2007
4
Identification of an acquired JAK2 mutation in polycythemia vera. (15863514)
2005

Genetic Variations for Acquired Polycythemia

Expression for genes affiliated with Acquired Polycythemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for genes affiliated with Acquired Polycythemia

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
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Compounds for genes affiliated with Acquired Polycythemia

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Acquired Polycythemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pp 100459.4EPO, JAK2
2anagrelide45 1110.4EPO, JAK2
3aminoguanidine45 29 1111.4EPO, JAK2
4hydroxyurea45 50 1111.4JAK2, EPO
5gp 130459.4EPO, JAK2
6imatinib45 50 1111.4EPO, JAK2
75-aza-2deoxycytidine459.3EPO, JAK2
8ascorbic acid45 2410.3JAK2, EPO
9butyrate459.3EPO, JAK2
10rapamycin459.2EPO, JAK2
11ly294002459.2EPO, JAK2
12cyclosporin a45 29 6011.1JAK2, EPO
13aspartate459.1EPO, JAK2
14cisplatin45 50 60 1112.0EPO, JAK2
15thymidine45 249.8EPO, JAK2

GO Terms for genes affiliated with Acquired Polycythemia

Sources:
16Gene Ontology
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Biological processes related to Acquired Polycythemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:0082849.1EPO, JAK2
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.0EPO, JAK2
3response to lipopolysaccharideGO:0324968.8EPO, JAK2

Products for genes affiliated with Acquired Polycythemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acquired Polycythemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet