MCID: ACQ016
MIFTS: 26

Acquired Pure Red Cell Aplasia malady

Rare diseases, Immune diseases, Blood diseases categories
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Summaries for Acquired Pure Red Cell Aplasia

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Acquired pure red cell aplasia (prca) is a bone marrow disorder characterized by a reduction of red blood cells (erythrocytes) produced by the bone marrow. signs and symptoms may include fatigue, lethargy, and/or abnormal paleness of the skin (pallor) due to the anemia the caused by the disorder. in most cases, the cause of acquired prca is unknown (idiopathic). in other cases it may occur secondary to autoimmune disorders, tumors of the thymus gland (thymomas), hematologic cancers, solid tumors, viral infections, or certain drugs. treatment depends on the cause of the condition (if known) but often includes transfusions for individuals who are severely anemic and have cardiorespiratory failure. last updated: 12/14/2011

MalaCards: Acquired Pure Red Cell Aplasia, also known as adult pure red cell aplasia, is related to pure red-cell aplasia and transient erythroblastopenia of childhood. An important gene associated with Acquired Pure Red Cell Aplasia is EPO (erythropoietin). Affiliated tissues include bone, bone marrow and skin.

Aliases & Classifications for Acquired Pure Red Cell Aplasia

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43NIH Rare Diseases, 49Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

acquired pure red cell aplasia 43
adult pure red cell aplasia 43 49
idiopathic pure red cell aplasia 43
acquired prca 43


External Ids:

ICD10 via Orphanet26 D60.0
ICD1025 D60

Related Diseases for Acquired Pure Red Cell Aplasia

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17GeneCards, 18GeneDecks
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Diseases related to Acquired Pure Red Cell Aplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1pure red-cell aplasia11.2
2transient erythroblastopenia of childhood10.7
3enterocele10.5
4chronic lymphocytic leukemia10.4
5kidney disease10.4
6leukemia10.4
7thrombocytopenia10.4
8thyroiditis10.4
9systemic lupus erythematosus10.4
10lupus erythematosus10.4

Graphical network of diseases related to Acquired Pure Red Cell Aplasia:



Diseases related to acquired pure red cell aplasia

Symptoms for Acquired Pure Red Cell Aplasia

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Drugs & Therapeutics for Acquired Pure Red Cell Aplasia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Acquired Pure Red Cell Aplasia

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Anatomical Context for Acquired Pure Red Cell Aplasia

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33MalaCards
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MalaCards organs/tissues related to Acquired Pure Red Cell Aplasia:

33
Bone, Bone marrow, Skin, Thymus, Testes, Kidney, Thyroid, Myeloid, T cells, B cells

Animal Models for Acquired Pure Red Cell Aplasia or affiliated genes

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Publications for Acquired Pure Red Cell Aplasia

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52PubMed
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Articles related to Acquired Pure Red Cell Aplasia:

(show all 40)
idTitleAuthorsYear
1
Acquired pure red cell aplasia due to anti-erythropoietin antibodies in a patient with end stage chronic kidney disease. (23817942)
2013
2
Low-dose subcutaneous alemtuzumab is a safe and effective treatment for chronic acquired pure red cell aplasia. (24310664)
2013
3
Successful treatment of acquired pure red cell aplasia with oral corticosteroids in a patient with B-cell CLL. (24234432)
2013
4
Acquired pure red cell aplasia due to treatment with clopidogrel: first case report. (24297264)
2013
5
Acquired Pure Red Cell Aplasia caused by Parvovirus B19 Infection following a Renal Transplant. (21969904)
2011
6
First case report of acquired pure red cell aplasia associated with micafungin. (21532231)
2011
7
Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group. (19195037)
2009
8
Diagnosis and management of acquired pure red cell aplasia. (19327582)
2009
9
Acquired pure red cell aplasia: updated review of treatment. (18510682)
2008
10
Three episodes of acquired pure red cell aplasia restricted to pregnancy. (18576941)
2008
11
Antibody-mediated acquired pure red cell aplasia (PRCA) after treatment with darbepoetin. (17314208)
2007
12
Response to high-dose dexamethasone for acquired pure red cell aplasia following ABO-mismatched allogeneic stem cell transplantation. (16699532)
2006
13
Successful treatment of acquired pure red cell aplasia (PRCA) by allogeneic peripheral blood stem cell transplantation. (14635209)
2003
14
Acquired pure red cell aplasia in a hemodialyzed patient. (14516404)
2003
15
A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. (12132531)
2002
16
Acquired pure red cell aplasia in a child. (12082327)
2002
17
Restoration of erythropoiesis by rituximab in an adult patient with primary acquired pure red cell aplasia refractory to conventional treatment. (11879264)
2002
18
Successful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulin. (11421300)
2001
19
Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. (11435321)
2001
20
Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation. (10382963)
1999
21
Acquired pure red cell aplasia--a case report. (10874372)
1998
22
Acquired pure red cell aplasia in Japan. (9338617)
1997
23
Acquired pure red cell aplasia: a study of six cases. (7578524)
1995
24
Resolution of transfusion dependence by recombinant human erythropoietin (rHuEPO) in acquired pure red cell aplasia (PRCA) associated with myeloid metaplasia. (8435333)
1993
25
Acquired pure red cell aplasia: is chloroquine a culprit? (8307924)
1993
26
Steroid-resistant acquired pure red cell aplasia: a partial remission induced by recombinant human erythropoietin. (1911372)
1991
27
The possible involvement of interferons in acquired pure red cell aplasia. (2451423)
1988
28
Acquired pure red cell aplasia. (3103428)
1987
29
Remission of acquired pure red cell aplasia following plasma exchanges. (3918338)
1985
30
Acquired pure red-cell aplasia: a consequence of increased natural killer cell activity? (6700259)
1984
31
Acquired pure red cell aplasia associated with chronic lymphocytic leukemia. (6821851)
1983
32
Acquired pure red cell aplasia associated with thyroid carcinoma: case report. (6401898)
1983
33
Acquired pure red cell aplasia: case report of a patient responding to prednisone. (7160328)
1982
34
Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. (6789590)
1981
35
Electron microscopic demonstration of IgG antibodies directed to erythroblast in primary acquired pure red cell aplasia. (6448720)
1980
36
Acquired pure red-cell aplasia in adults. (4749529)
1973
37
Acquired pure red cell aplasia. (20791480)
1968
38
Acquired pure red cell aplasia. (4972858)
1968
39
Therapeutic considerations in acquired pure red cell aplasia in adults. (6051100)
1967
40
Corticosteroid-responsive acquired pure red cell aplasia in adults. (6054841)
1967

Variations for Acquired Pure Red Cell Aplasia

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Expression for genes affiliated with Acquired Pure Red Cell Aplasia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Pure Red Cell Aplasia

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Pathways for genes affiliated with Acquired Pure Red Cell Aplasia

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Compounds for genes affiliated with Acquired Pure Red Cell Aplasia

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GO Terms for genes affiliated with Acquired Pure Red Cell Aplasia

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Products for genes affiliated with Acquired Pure Red Cell Aplasia

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Sources for Acquired Pure Red Cell Aplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet