MCID: ACQ016
MIFTS: 25

Acquired Pure Red Cell Aplasia malady

Categories: Rare diseases, Immune diseases, Blood diseases

Aliases & Classifications for Acquired Pure Red Cell Aplasia

Aliases & Descriptions for Acquired Pure Red Cell Aplasia:

Name: Acquired Pure Red Cell Aplasia 50
Adult Pure Red Cell Aplasia 50 56
Idiopathic Pure Red Cell Aplasia 50
Acquired Red Cell Aplasia 69
Acquired Prca 50

Classifications:



External Ids:

Orphanet 56 ORPHA98872
ICD10 via Orphanet 34 D60.0
ICD10 33 D60

Summaries for Acquired Pure Red Cell Aplasia

NIH Rare Diseases : 50 acquired pure red cell aplasia (prca) is a bone marrow disorder characterized by a reduction of red blood cells (erythrocytes) produced by the bone marrow. signs and symptoms may include fatigue, lethargy, and/or abnormal paleness of the skin (pallor) due to the anemia the caused by the disorder. in most cases, the cause of acquired prca is unknown (idiopathic). in other cases it may occur secondary to autoimmune disorders, tumors of the thymus gland (thymomas), hematologic cancers, solid tumors, viral infections, or certain drugs. treatment depends on the cause of the condition (if known) but often includes transfusions for individuals who are severely anemic and have cardiorespiratory failure. last updated: 12/14/2011

MalaCards based summary : Acquired Pure Red Cell Aplasia, also known as adult pure red cell aplasia, is related to transient erythroblastopenia of childhood and pure red-cell aplasia. The drugs Iron and Deferasirox have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin.

Related Diseases for Acquired Pure Red Cell Aplasia

Diseases related to Acquired Pure Red Cell Aplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 transient erythroblastopenia of childhood 11.8
2 pure red-cell aplasia 10.7
3 rheumatoid arthritis 9.9
4 arthritis 9.9
5 chronic lymphocytic leukemia 9.9
6 hematopoietic stem cell transplantation 9.9
7 leukemia 9.9
8 thrombocytopenia 9.9
9 lymphoma 9.9
10 thymoma 9.9
11 kidney disease 9.9
12 thyroiditis 9.9
13 acquired amegakaryocytic thrombocytopenia 9.9

Graphical network of the top 20 diseases related to Acquired Pure Red Cell Aplasia:



Diseases related to Acquired Pure Red Cell Aplasia

Symptoms & Phenotypes for Acquired Pure Red Cell Aplasia

Drugs & Therapeutics for Acquired Pure Red Cell Aplasia

Drugs for Acquired Pure Red Cell Aplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Deferasirox Approved, Investigational Phase 4 201530-41-8 5493381
3 Chelating Agents Phase 4
4 Trace Elements Phase 4
5 Iron Chelating Agents Phase 4
6 Liver Extracts Phase 4
7 Micronutrients Phase 4
8
alemtuzumab Approved, Investigational Phase 2 216503-57-0
9
Lenograstim Approved Phase 2 135968-09-1
10
Melphalan Approved 148-82-3 4053 460612
11
Fludarabine Approved 21679-14-1, 75607-67-9 30751
12
Busulfan Approved, Investigational 55-98-1 2478
13 vitamin d
14 interferons
15 Mitogens
16 Vitamins
17 Interferon-gamma
18 Interleukin 1 Receptor Antagonist Protein
19 Vaccines

Interventional clinical trials:


id Name Status NCT ID Phase
1 Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload Completed NCT00673608 Phase 4
2 Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes Completed NCT00004143 Phase 2
3 Identifying Characteristics of Bone Marrow Failure Syndromes Unknown status NCT00315419
4 Cytokine Gene Polymorphisms in Bone Marrow Failure Completed NCT00085670
5 CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease Recruiting NCT01966367

Search NIH Clinical Center for Acquired Pure Red Cell Aplasia

Genetic Tests for Acquired Pure Red Cell Aplasia

Anatomical Context for Acquired Pure Red Cell Aplasia

MalaCards organs/tissues related to Acquired Pure Red Cell Aplasia:

39
Bone, Bone Marrow, Skin, Thymus, T Cells, Myeloid, B Cells

Publications for Acquired Pure Red Cell Aplasia

Articles related to Acquired Pure Red Cell Aplasia:

(show all 43)
id Title Authors Year
1
Successful high-dose dexamethasone treatment of acquired pure red cell aplasia following ABO major mismatched allogeneic hematopoietic stem cell transplantation. ( 27384857 )
2016
2
Acquired pure red cell aplasia in a patient of rheumatoid arthritis. ( 25332592 )
2014
3
Acquired pure red cell aplasia due to anti-erythropoietin antibodies in a patient with end stage chronic kidney disease. ( 23817942 )
2013
4
Successful treatment of acquired pure red cell aplasia with oral corticosteroids in a patient with B-cell CLL. ( 24234432 )
2013
5
Acquired pure red cell aplasia due to treatment with clopidogrel: first case report. ( 24297264 )
2013
6
Low-dose subcutaneous alemtuzumab is a safe and effective treatment for chronic acquired pure red cell aplasia. ( 24310664 )
2013
7
First case report of acquired pure red cell aplasia associated with micafungin. ( 21532231 )
2011
8
Acquired Pure Red Cell Aplasia caused by Parvovirus B19 Infection following a Renal Transplant. ( 21969904 )
2011
9
Diagnosis and management of acquired pure red cell aplasia. ( 19327582 )
2009
10
Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group. ( 19195037 )
2009
11
Three episodes of acquired pure red cell aplasia restricted to pregnancy. ( 18576941 )
2008
12
Acquired pure red cell aplasia: updated review of treatment. ( 18510682 )
2008
13
Antibody-mediated acquired pure red cell aplasia (PRCA) after treatment with darbepoetin. ( 17314208 )
2007
14
Response to high-dose dexamethasone for acquired pure red cell aplasia following ABO-mismatched allogeneic stem cell transplantation. ( 16699532 )
2006
15
Successful treatment of acquired pure red cell aplasia (PRCA) by allogeneic peripheral blood stem cell transplantation. ( 14635209 )
2003
16
Acquired pure red cell aplasia in a hemodialyzed patient. ( 14516404 )
2003
17
Acquired pure red cell aplasia in a child. ( 12082327 )
2002
18
Restoration of erythropoiesis by rituximab in an adult patient with primary acquired pure red cell aplasia refractory to conventional treatment. ( 11879264 )
2002
19
A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. ( 12132531 )
2002
20
Successful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulin. ( 11421300 )
2001
21
Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. ( 11435321 )
2001
22
Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation. ( 10382963 )
1999
23
Acquired pure red cell aplasia--a case report. ( 10874372 )
1998
24
Acquired pure red cell aplasia in Japan. ( 9338617 )
1997
25
Acquired pure red cell aplasia: a study of six cases. ( 7578524 )
1995
26
Acquired pure red cell aplasia: is chloroquine a culprit? ( 8307924 )
1993
27
Resolution of transfusion dependence by recombinant human erythropoietin (rHuEPO) in acquired pure red cell aplasia (PRCA) associated with myeloid metaplasia. ( 8435333 )
1993
28
Steroid-resistant acquired pure red cell aplasia: a partial remission induced by recombinant human erythropoietin. ( 1911372 )
1991
29
Acquired pure red cell aplasia without thymoma. ( 2123184 )
1990
30
The possible involvement of interferons in acquired pure red cell aplasia. ( 2451423 )
1988
31
Acquired pure red cell aplasia. ( 3103428 )
1987
32
Remission of acquired pure red cell aplasia following plasma exchanges. ( 3918338 )
1985
33
Acquired pure red-cell aplasia: a consequence of increased natural killer cell activity? ( 6700259 )
1984
34
Acquired pure red cell aplasia associated with thyroid carcinoma: case report. ( 6401898 )
1983
35
Acquired pure red cell aplasia associated with chronic lymphocytic leukemia. ( 6821851 )
1983
36
Acquired pure red cell aplasia: case report of a patient responding to prednisone. ( 7160328 )
1982
37
Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. ( 6789590 )
1981
38
Electron microscopic demonstration of IgG antibodies directed to erythroblast in primary acquired pure red cell aplasia. ( 6448720 )
1980
39
Acquired pure red-cell aplasia in adults. ( 4749529 )
1973
40
Acquired pure red cell aplasia. ( 20791480 )
1968
41
Acquired pure red cell aplasia. ( 4972858 )
1968
42
Therapeutic considerations in acquired pure red cell aplasia in adults. ( 6051100 )
1967
43
Corticosteroid-responsive acquired pure red cell aplasia in adults. ( 6054841 )
1967

Variations for Acquired Pure Red Cell Aplasia

Expression for Acquired Pure Red Cell Aplasia

Search GEO for disease gene expression data for Acquired Pure Red Cell Aplasia.

Pathways for Acquired Pure Red Cell Aplasia

GO Terms for Acquired Pure Red Cell Aplasia

Sources for Acquired Pure Red Cell Aplasia

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70 UMLS via Orphanet
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