MCID: ACQ005
MIFTS: 34

Acquired Thrombocytopenia

Categories: Immune diseases, Blood diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 14 69
Secondary Thrombocytopenia 12 51
Secondary Thrombocytopenia Nos 12
Preliminary Data 41

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD10 32 D69.5
ICD9CM 34 287.4
UMLS 69 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to thrombocytopenia and thrombocytopenic purpura, autoimmune. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are PAK Pathway and Jak-STAT signaling pathway (KEGG). The drugs Bivalirudin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Acquired Thrombocytopenia Thrombocytopenia Due to Platelet Alloimmunization
Primary Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 29.9 IL11 THPO
2 thrombocytopenic purpura, autoimmune 10.0 IL11 THPO
3 dengue disease 10.0 IL11 THPO
4 thrombocytosis 10.0 IL11 THPO
5 megakaryocytic leukemia 10.0 IL11 THPO
6 hemorrhagic disease 9.9 F11 THPO
7 deficiency anemia 9.9 IL11 THPO
8 essential thrombocythemia 9.9 IL11 THPO
9 aplastic anemia 9.6 IL11 THPO
10 retinitis 9.6
11 myocardial infarction 9.6
12 acute myocardial infarction 9.6
13 heart disease 9.6
14 heparin-induced thrombocytopenia 9.6
15 alzheimer disease 9.5
16 breast cancer 9.5
17 allergic rhinitis 9.5
18 psoriatic arthritis 9.5
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.5
20 arthritis 9.5
21 bronchopulmonary dysplasia 9.5
22 myelomeningocele 9.5
23 dementia 9.5
24 acromegaly 9.5
25 transitional cell carcinoma 9.5
26 rhinitis 9.5
27 cardiogenic shock 9.5
28 colorectal cancer 9.4
29 multiple sclerosis 9.4
30 systemic lupus erythematosus 9.4
31 ovarian cancer 9.4

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Anemia, Autoimmune Hemolytic Aortic Valve Disease 1
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Ischemic Heart Disease
Leukemia, Chronic Lymphocytic Megakaryocytic Leukemia
Mitral Valve Disease Neutropenia
Oral Candidiasis Portal Hypertension
Primary Thrombocytopenia Protein-Energy Malnutrition
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2 Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
2
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
3
Thrombin Approved, Investigational Phase 3
4 Anticoagulants Phase 3
5 Antithrombin III Phase 3
6 Antithrombins Phase 3
7 calcium heparin Phase 3
8 Calcium, Dietary Phase 3
9 Fibrinolytic Agents Phase 3
10 Hirudins Phase 3
11 HIV Protease Inhibitors Phase 3
12
protease inhibitors Phase 3
13 Serine Proteinase Inhibitors Phase 3
14 serine Nutraceutical Phase 3
15
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
16
Daunorubicin Approved Phase 2 20830-81-3 30323
17 Anti-Bacterial Agents Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Anti-Infective Agents Phase 2
20 Antimetabolites Phase 2
21 Antimetabolites, Antineoplastic Phase 2
22 Antiviral Agents Phase 2
23 Immunosuppressive Agents Phase 2
24 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed NCT01651780 Phase 3 Bivalirudin;Unfractionated Heparin
2 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2 eltrombopag
3 A Safety and Efficacy Study of Eltrombopag in Subjects With AML Completed NCT01890746 Phase 2 Daunorubicin;Cytarabine;Eltrombopag;Placebo
4 WEUSKOP5410: Observational Study in ENABLE Clinical Trials Completed NCT01458080 eltrombopag

Search NIH Clinical Center for Acquired Thrombocytopenia

Cochrane evidence based reviews: preliminary data

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

38
Heart

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 14)
# Title Authors Year
1
Recent advances in understanding and management of acquired thrombocytopenia. ( 29399327 )
2018
2
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. ( 29368387 )
2018
3
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )
2016
4
Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )
2014
5
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )
2014
6
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )
2014
7
Hospital-acquired thrombocytopenia. ( 25502138 )
2014
8
Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )
2012
9
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )
2011
10
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )
2005
11
Congenital and acquired thrombocytopenia. ( 15561694 )
2004
12
Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )
2004
13
Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )
1972
14
Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )
1956

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

GO Terms for Acquired Thrombocytopenia

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL11 THPO
2 growth factor activity GO:0008083 8.62 IL11 THPO

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....