MCID: ACQ005
MIFTS: 35

Acquired Thrombocytopenia malady

Categories: Immune diseases, Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Acquired Thrombocytopenia

Aliases & Descriptions for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 14 69
Secondary Thrombocytopenia 12 52
Secondary Thrombocytopenia Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD10 33 D69.5
ICD9CM 35 287.4
UMLS 69 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to vulvar childhood botryoid-type embryonal rhabdomyosarcoma and acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Bivalirudin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 4 Thrombocytopenia 2
Thrombocytopenia 5 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Myh9 Related Thrombocytopenia Mastl-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia Thrombocytopenia 6

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 vulvar childhood botryoid-type embryonal rhabdomyosarcoma 10.3 SIK1 SLC35G5
2 acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia 10.3 F11 F8
3 acromegaloid hypertrichosis syndrome 10.2 F11 F8
4 agammaglobulinemia 2 10.2 CBL KCNJ11 SLC35G5
5 acrodysplasia scoliosis 10.2 F11 F8
6 zika virus congenital syndrome 10.2 F8 SERPINC1 THPO
7 freiberg's disease 10.2 F8 SERPINC1
8 scapuloperoneal myopathy, x-linked dominant 10.2 F11 F8 SERPINC1
9 pregnancy loss, recurrent 2 10.2 F11 F8 SERPINC1
10 aids dementia complex 10.2 F11 F8 SERPINC1
11 haemonchiasis 10.1 ITGA2B SERPINC1 THPO
12 essential thrombocythemia 10.1 F8 ITGA2B SERPINC1
13 functional diarrhea 10.1 ATP12A ATP4A
14 scrotum melanoma 10.1 ATP12A ATP4A
15 congenital diaphragmatic hernia 10.1 ATP12A ATP4A
16 secondary syphilis 10.1 ATP12A ATP4A
17 brain edema 10.1 ATP12A ATP4A
18 intracranial hypertension 10.1 ATP12A ATP4A
19 staphyloenterotoxemia 10.1 ATP12A ATP4A
20 microphthalmia, syndromic 12 10.1 ATP12A ATP4A
21 amyotrophic lateral sclerosis type 10 10.1 ATP12A ATP4A
22 cytokine receptor deficiency 10.1 IL11 THPO
23 phencyclidine abuse 10.1 F8 WT1
24 ocular hyperemia 10.1 F8 ITGA2B SERPINC1 THPO
25 myeloproliferative neoplasm 10.1 F8 ITGA2B SERPINC1 THPO
26 membranoproliferative glomerulonephritis 10.1 F8 ITGA2B SERPINC1 THPO
27 abnormal pupillary function 10.0 ATP12A ATP4A
28 thrombocytopenia 10.0
29 mesenteric vascular occlusion 10.0 ATP12A ATP4A WT1
30 adult extraosseous chondrosarcoma 10.0 ATP12A ATP4A
31 perichondritis of auricle 10.0 F11 F8 ITGA2B SERPINC1 THPO
32 tracheal disease 10.0 IL11 ITGA2B SERPINC1 THPO
33 synostosis 9.9 ATP12A ATP4A
34 ceruminoma 9.8 ATP12A ATP4A IFNA1
35 basilar artery insufficiency 9.8 IFNA1 IL11 ITGA2B THPO
36 myocardial infarction 9.5
37 acute myocardial infarction 9.5
38 heparin-induced thrombocytopenia 9.5
39 prostatic cyst 7.9 ATP12A ATP4A CBL CD1A CTNNA1 CTPS1

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Aplastic Anemia Autoimmune Hemolytic Anemia
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Ventricular Outflow Tract Obstruction Leukemia, B-Cell, Chronic
Megakaryocytic Leukemia Mitral Valve Disease
Neutropenia Oral Candidiasis
Portal Hypertension Primary Thrombocytopenia
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
2
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
3
Dalteparin Approved Phase 3 9041-08-1
4
Levoleucovorin Approved Phase 3 68538-85-2
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Trimetrexate Approved, Investigational Phase 3 52128-35-5 5583
7
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
8
Peginterferon alfa-2a Approved, Investigational Phase 3 198153-51-4 5360545
9
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
10
Ribavirin Approved Phase 3 36791-04-5 37542
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
13 tannic acid Approved, Nutraceutical Phase 3
14 Anticoagulants Phase 3
15 Fibrinolytic Agents Phase 3
16 Antithrombin III Phase 3
17 Antithrombins Phase 3
18 calcium heparin Phase 3
19 Calcium, Dietary Phase 3
20 Hirudins Phase 3
21 HIV Protease Inhibitors Phase 3,Phase 2
22
protease inhibitors Phase 3,Phase 2
23 Serine Proteinase Inhibitors Phase 3
24 Thrombin Phase 3
25 Heparin, Low-Molecular-Weight Phase 3
26 Antidotes Phase 3
27 Antifungal Agents Phase 3
28 Anti-Infective Agents Phase 3,Phase 2
29 Antimetabolites Phase 3,Phase 2,Phase 1
30 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
31 Antiprotozoal Agents Phase 3
32 Folic Acid Antagonists Phase 3
33 Protective Agents Phase 3,Phase 1,Phase 2
34 Vitamin B Complex Phase 3
35 Antiviral Agents Phase 3,Phase 2
36 interferons Phase 3
37 Liver Extracts Phase 3,Phase 2,Phase 1
38 serine Nutraceutical Phase 3
39 Folate Nutraceutical Phase 3
40 Vitamin B9 Nutraceutical Phase 3
41
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
42
Daunorubicin Approved Phase 2 20830-81-3 30323
43
rituximab Approved Phase 2 174722-31-7 10201696
44
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
45
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
46
Decitabine Approved, Investigational Phase 2 2353-33-5 451668
47
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
48
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
49
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
50
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751

Interventional clinical trials:

(show all 26)
id Name Status NCT ID Phase
1 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4
2 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed NCT01651780 Phase 3
3 PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT Pilot) Completed NCT00182364 Phase 3
4 An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies Completed NCT00000714 Phase 3
5 Clinical Trial for Non-responders Who Previously Participated in Eltrombopag Studies TPL 103922 or TPL 108390 Completed NCT00996216 Phase 3
6 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Benefit Subjects With Hepatitis C Liver Disease Completed NCT00529568 Phase 3
7 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Subjects With Hepatitis C Related Liver Disease Completed NCT00516321 Phase 3
8 Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura Recruiting NCT02553317 Phase 3
9 Follow-up Study for Patients Who Completed Study ALX0681-C301 (Post-HERCULES) Recruiting NCT02878603 Phase 3
10 Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedures Terminated NCT00678587 Phase 3
11 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2
12 A Safety and Efficacy Study of Eltrombopag in Subjects With AML Completed NCT01890746 Phase 2
13 Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Completed NCT00907751 Phase 2
14 Japanese Phase II Study of SB-497115-GR in Hepatitis C Virus Infected Patients Completed NCT01636778 Phase 2
15 Study to Assess Efficacy and Safety of Anti-von Willebrand Factor Nanobody in Patients With Acquired Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT01151423 Phase 2
16 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2
17 A Multi-center Study of Low-dose Decitabine for the Treatment of Immune Thrombocytopenia Recruiting NCT01568333 Phase 2
18 Low Dose Rituximab in Thrombotic Thrombocytopenic Purpura Recruiting NCT01554514 Phase 2
19 CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant Recruiting NCT02061800 Phase 1, Phase 2
20 A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia Completed NCT00002258 Phase 1
21 Ex Vivo Laboratory Assays Application for Therapy Tailoring in Patients With Severe Bleeding Disorders Unknown status NCT02324517
22 WEUSKOP5410: Observational Study in ENABLE Clinical Trials Completed NCT01458080
23 Continuous High-Dose Intravenous Dextran Sulfate in Human Immunodeficiency Virus-Infected Individuals Completed NCT00000684
24 ADAMTS13 in Thrombotic Thrombocytopenic Purpura Completed NCT00426686
25 CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease Recruiting NCT01966367
26 Improving Diagnosis in Idiopathic Cytopenia Using Gene Sequencing Not yet recruiting NCT03026751

Search NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

39
Heart

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 12)
id Title Authors Year
1
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )
2016
2
Hospital-acquired thrombocytopenia. ( 25502138 )
2014
3
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )
2014
4
Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )
2014
5
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )
2014
6
Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )
2012
7
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )
2011
8
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )
2005
9
Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )
2004
10
Congenital and acquired thrombocytopenia. ( 15561694 )
2004
11
Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )
1972
12
Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )
1956

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

Pathways related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 IL11 ITGA2B THPO
2 10.91 CD1A IL11 ITGA2B THPO

GO Terms for Acquired Thrombocytopenia

Cellular components related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ATP4A F11 F8 IFNA1 IL11 SERPINC1
2 flotillin complex GO:0016600 8.62 CBL CTNNA1

Biological processes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 CBL CTNNA1 WT1
2 regulation of blood coagulation GO:0030193 9.37 F11 SERPINC1
3 blood coagulation, intrinsic pathway GO:0007597 9.32 F11 F8
4 blood coagulation GO:0007596 9.26 F11 F8 IFNA1 SERPINC1
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 hemostasis GO:0007599 8.8 F11 F8 SERPINC1

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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