MCID: ACQ005
MIFTS: 36

Acquired Thrombocytopenia

Categories: Immune diseases, Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 14 69
Secondary Thrombocytopenia 12 52
Secondary Thrombocytopenia Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD10 33 D69.5
ICD9CM 35 287.4
UMLS 69 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to cystic adventitial disease and polyembryoma of the ovary. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Azathioprine and Hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include liver and heart.

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 3 Thrombocytopenia 4
Thrombocytopenia 2 Thrombocytopenia 5
Thrombocytopenia 6 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Myh9 Related Thrombocytopenia Mastl-Related Thrombocytopenia 2
Gata1-Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 cystic adventitial disease 10.8 IL11 THPO
2 polyembryoma of the ovary 10.8 SIK1 SLC35G5
3 acquired von willebrand syndrome 10.7 F11 F8
4 acro-pectoro-renal field defect 10.7 F11 F8
5 acquired pure red cell aplasia 10.7 F11 F8
6 papillary meningioma of the cerebellum 10.6 F8 WT1
7 thrombocytopenic purpura, autoimmune 10.6 IL11 ITGA2B THPO
8 female breast cancer 10.6 F11 F8
9 mental depression 10.5 ITGA2B THPO
10 microcystic adenoma 10.5 IL11 ITGA2B THPO
11 fragile x syndrome type 2 10.5 F8 SERPINC1
12 granulomatous hepatitis 10.5 IL11 SERPINC1 THPO
13 immunodeficiency 21 10.5 F8 ITGA2B THPO
14 glomerulosclerosis, focal segmental, 2 10.4 F11 F8 SERPINC1
15 scapuloperoneal myopathy, x-linked dominant 10.4 F11 F8 SERPINC1
16 otopalatodigital syndrome, type i 10.4 F11 F8 SERPINC1
17 hemoglobin zurich 10.3 KCNJ11 WT1
18 partial sensory epilepsy 10.3 ITGA2B SERPINC1 THPO
19 scrotum melanoma 10.3 ATP12A ATP4A
20 congenital aphakia 10.3 ATP12A ATP4A
21 shwartzman phenomenon 10.3 ATP12A ATP4A
22 primary syphilis 10.3 ATP12A ATP4A
23 bone giant cell sarcoma 10.3 ATP12A ATP4A
24 urethral calculus 10.3 ATP12A ATP4A
25 hypopituitarism 10.3 ATP12A ATP4A
26 amyotrophic lateral sclerosis type 5 10.3 ATP12A ATP4A
27 abnormal pupillary function 10.3 ATP12A ATP4A
28 essential thrombocythemia 10.2 F8 ITGA2B SERPINC1
29 atheroembolism of kidney 10.2 ATP12A ATP4A
30 microphthalmia, syndromic 12 10.2 ATP12A ATP4A
31 synostosis 10.2 ATP12A ATP4A
32 muscle cancer 10.2 ATP12A ATP4A
33 adult xanthogranuloma 10.2 ATP12A ATP4A
34 polysyndactyly with cardiac malformation 10.2 ATP12A ATP4A
35 focal hand dystonia 10.2 ATP12A ATP4A
36 cloacal exstrophy 10.1 ATP12A ATP4A
37 thrombocytopenia due to platelet alloimmunization 10.1 ATP12A ATP4A
38 proliferative fasciitis 10.1 ATP12A ATP4A
39 tracheal cancer 10.1 IL11 ITGA2B THPO
40 ocular hyperemia 10.1 F8 ITGA2B SERPINC1 THPO
41 myeloproliferative neoplasm 10.1 F8 ITGA2B SERPINC1 THPO
42 lacrimal system cancer 10.1 F8 ITGA2B SERPINC1 THPO
43 hodgkin's paragranuloma 10.1 ATP12A ATP4A
44 thrombocytopenia 10.0
45 bladder neck cancer 10.0 ATP12A ATP4A
46 mesenteric vascular occlusion 10.0 ATP12A ATP4A WT1
47 spinocerebellar ataxia 18 9.9 ATP12A ATP4A
48 rheumatoid lung disease 9.8 F8 SERPINC1
49 perichondritis of auricle 9.8 F11 F8 ITGA2B SERPINC1 THPO
50 basilar artery insufficiency 9.7 IFNA1 IL11 ITGA2B THPO

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Aplastic Anemia Autoimmune Hemolytic Anemia
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Ventricular Outflow Tract Obstruction Leukemia, B-Cell, Chronic
Megakaryocytic Leukemia Mitral Valve Disease
Neutropenia Oral Candidiasis
Portal Hypertension Primary Thrombocytopenia
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Hydroxychloroquine Approved Phase 4 118-42-3 3652
3
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
5
Clarithromycin Approved Phase 4 81103-11-9 84029
6 Anti-Infective Agents Phase 4,Phase 2
7 Antimetabolites Phase 4,Phase 2
8 Antimetabolites, Antineoplastic Phase 4,Phase 2
9 Antirheumatic Agents Phase 4,Phase 2
10 Immunosuppressive Agents Phase 4,Phase 2
11 Anti-Bacterial Agents Phase 4,Phase 2
12 Antimalarials Phase 4
13 Antimitotic Agents Phase 4
14 Antineoplastic Agents, Phytogenic Phase 4
15 Antiparasitic Agents Phase 4
16 Antiprotozoal Agents Phase 4
17 Cytochrome P-450 CYP3A Inhibitors Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19
Proton pump inhibitors Phase 4
20
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
21
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
22
Thrombin Approved Phase 3
23
Dalteparin Approved Phase 3 9005-49-6
24 Anticoagulants Phase 3
25 Antithrombin III Phase 3
26 Antithrombins Phase 3
27 calcium heparin Phase 3
28 Calcium, Dietary Phase 3
29 Fibrinolytic Agents Phase 3
30 Hirudins Phase 3
31 HIV Protease Inhibitors Phase 3,Phase 2
32
protease inhibitors Phase 3,Phase 2
33 Serine Proteinase Inhibitors Phase 3
34 Heparin, Low-Molecular-Weight Phase 3
35 Liver Extracts Phase 3,Phase 2
36 serine Nutraceutical Phase 3
37
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
38
Daunorubicin Approved Phase 2 20830-81-3 30323
39
rituximab Approved Phase 2 174722-31-7 10201696
40
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
41
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
42
Decitabine Approved, Investigational Phase 2 2353-33-5 451668
43 Antibiotics, Antitubercular Phase 2
44 Antiviral Agents Phase 2
45 Topoisomerase Inhibitors Phase 2
46 Antiemetics Phase 2
47 Anti-Inflammatory Agents Phase 2
48 Antineoplastic Agents, Hormonal Phase 2
49 Autonomic Agents Phase 2
50 BB 1101 Phase 2

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Not yet recruiting NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
2 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
3 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed NCT01651780 Phase 3 Bivalirudin;Unfractionated Heparin
4 PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT Pilot) Completed NCT00182364 Phase 3 Fragmin (Dalteparin) LMWH verus Unfractionated Heparin (UFH)
5 Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura Completed NCT02553317 Phase 3
6 Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedures Terminated NCT00678587 Phase 3 Eltrombopag;Placebo
7 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2 eltrombopag
8 A Safety and Efficacy Study of Eltrombopag in Subjects With AML Completed NCT01890746 Phase 2 Daunorubicin;Cytarabine;Eltrombopag;Placebo
9 Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Completed NCT00907751 Phase 2 rituximab
10 Japanese Phase II Study of SB-497115-GR in Hepatitis C Virus Infected Patients Completed NCT01636778 Phase 2 SB-497115-GR
11 Study to Assess Efficacy and Safety of Anti-von Willebrand Factor Nanobody in Patients With Acquired Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT01151423 Phase 2
12 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
13 A Multi-center Study of Low-dose Decitabine for the Treatment of Immune Thrombocytopenia Recruiting NCT01568333 Phase 2 Decitabine
14 WEUSKOP5410: Observational Study in ENABLE Clinical Trials Completed NCT01458080 eltrombopag
15 Continuous High-Dose Intravenous Dextran Sulfate in Human Immunodeficiency Virus-Infected Individuals Completed NCT00000684 Dextran sulfate
16 ADAMTS13 in Thrombotic Thrombocytopenic Purpura Completed NCT00426686
17 CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation Recruiting NCT01966367 Early Phase 1

Search NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

39
Liver, Heart

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 12)
id Title Authors Year
1
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )
2016
2
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )
2014
3
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )
2014
4
Hospital-acquired thrombocytopenia. ( 25502138 )
2014
5
Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )
2014
6
Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )
2012
7
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )
2011
8
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )
2005
9
Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )
2004
10
Congenital and acquired thrombocytopenia. ( 15561694 )
2004
11
Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )
1972
12
Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )
1956

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

Pathways related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 IL11 THPO WT1
2 11.2 IL11 ITGA2B THPO
3 10.91 CD1A IL11 ITGA2B THPO

GO Terms for Acquired Thrombocytopenia

Cellular components related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 flotillin complex GO:0016600 8.62 CBL CTNNA1

Biological processes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 CBL CTNNA1 WT1
2 regulation of blood coagulation GO:0030193 9.37 F11 SERPINC1
3 blood coagulation, intrinsic pathway GO:0007597 9.32 F11 F8
4 blood coagulation GO:0007596 9.26 F11 F8 IFNA1 SERPINC1
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 hemostasis GO:0007599 8.8 F11 F8 SERPINC1

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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