MCID: ACQ017
MIFTS: 32

Acquired Von Willebrand Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Acquired Von Willebrand Syndrome

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Sources:
45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acquired Von Willebrand Syndrome:

Name: Acquired Von Willebrand Syndrome 45 51
Acquired Von Willebrand Disease 45 51
 
Willebrand Disease, Acquired 45

Characteristics:

Orphanet epidemiological data:

51
acquired von willebrand syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet51 99147
ICD10 via Orphanet28 D68.4
UMLS via Orphanet66 C0272362

Summaries for Acquired Von Willebrand Syndrome

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NIH Rare Diseases:45 Acquired von willebrand syndrome (avws) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a vwf gene mutation. it is most often seen in persons over age 40 years with no prior bleeding history. this condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. about 300 cases of this condition have been reported in the medical literature thus far. treatment depends on the underlying cause of the condition. last updated: 9/15/2011

MalaCards based summary: Acquired Von Willebrand Syndrome, also known as acquired von willebrand disease, is related to myoma and colorectal cancer. An important gene associated with Acquired Von Willebrand Syndrome is VWF (Von Willebrand Factor), and among its related pathways are Complement and coagulation cascades and Platelet activation. Affiliated tissues include heart, colon and prostate, and related mouse phenotype hematopoietic system.

Related Diseases for Acquired Von Willebrand Syndrome

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Graphical network of the top 20 diseases related to Acquired Von Willebrand Syndrome:



Diseases related to acquired von willebrand syndrome

Symptoms for Acquired Von Willebrand Syndrome

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Drugs & Therapeutics for Acquired Von Willebrand Syndrome

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Drugs for Acquired Von Willebrand Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Natriuretic AgentsPhase 41403
2VasopressinsPhase 4260
3HemostaticsPhase 41082
4Deamino Arginine VasopressinPhase 468
5Arginine VasopressinPhase 4264
6CoagulantsPhase 41042
7arginineNutraceuticalPhase 4364

Interventional clinical trials:

idNameStatusNCT IDPhase
1Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement SurgeryCompletedNCT01994330Phase 4
2Acquired Von Willebrand Syndrome in Severe Aortic StenosisCompletedNCT00805051
3ADAMTS13 in Thrombotic Thrombocytopenic PurpuraCompletedNCT00426686

Search NIH Clinical Center for Acquired Von Willebrand Syndrome

Genetic Tests for Acquired Von Willebrand Syndrome

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Anatomical Context for Acquired Von Willebrand Syndrome

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MalaCards organs/tissues related to Acquired Von Willebrand Syndrome:

33
Heart, Colon, Prostate, Breast, Skin, T cells, Lung

Animal Models for Acquired Von Willebrand Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Acquired Von Willebrand Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0F8, GP1BA, JAK2, VWF

Publications for Acquired Von Willebrand Syndrome

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Articles related to Acquired Von Willebrand Syndrome:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Expression of GRIM-19 inA adenomyosis and its possible roleA in pathogenesis. (26769301)
2016
2
Cryptorchidism and Fertility. (26568490)
2015
3
Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis. (25333705)
2014
4
CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile. (25221643)
2014
5
Laparoscopic choledochotomy followed by primary duct closure for choledocholithiasis. (24399527)
2014
6
Retinal degeneration in mucopolysaccharidose type II. (23208705)
2013
7
Pericardial effusion due to pericardium involvement by Hodgkin's lymphoma. (23196418)
2013
8
"Back to the future": toward Luria's holistic cultural science of human brain and mind in a historical study of mental retardation. (24027508)
2013
9
Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast. (24338134)
2013
10
Expression profiles and functional associations of endogenous androgen receptor and caveolin-1 in prostate cancer cell lines. (24375805)
2013
11
Intracellular cholestasis in HCV and HBV infection. (23113313)
2012
12
Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy. (23029491)
2012
13
Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome. (21400500)
2011
14
Successful treatment of an injury bleeding on a patient suffering from mild von Willebrand's disease and predisposition to allergic diseases, with recombinant factor VIIA. (21070492)
2011
15
Serum clusterin levels are not increased in presymptomatic Alzheimer's disease. (21280673)
2011
16
Combined use of urinary neutrophil gelatinase-associated lipocalin (uNGAL) and albumin as markers of early cardiac damage in primary hypertension. (21756891)
2011
17
Carrier frequency of GJB2 gene mutations c.35delG, c.235delC and c.167delT among the populations of Eurasia. (20739944)
2010
18
Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard. (20590642)
2010
19
Disseminated histoplasmosis by Histoplasma capsulatum var. duboisii in a paediatric patient from the Chad Republic, Africa. (19005708)
2009
20
Occlusion of the left coronary trunk secondary to tertiary syphilis. (19851661)
2009
21
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner. (18848576)
2008
22
Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature. (18344867)
2008
23
Effects of low- and high-flux dialyzers on oxidative stress and insulin resistance. (18285698)
2008
24
IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. (18495691)
2008
25
The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. (18212819)
2008
26
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (18194665)
2008
27
The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. (17498780)
2007
28
Coughing may lead to spontaneous chylothorax and chylous ascites. (21487566)
2007
29
erbB1 functions as a sensor of airway epithelial integrity by regulation of protein phosphatase 2A activity. (16293617)
2006
30
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF). (15653024)
2005
31
Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. (15890005)
2005
32
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. (15917292)
2005
33
RISC assembly defects in the Drosophila RNAi mutant armitage. (15035985)
2004
34
G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. (15280385)
2004
35
p63 is the molecular switch for initiation of an epithelial stratification program. (14729569)
2004
36
Effect of a dysmenorrhea Chinese medicinal prescription on uterus contractility in vitro. (12916077)
2003
37
Small intestinal angiolipoma: MR imaging appearance. (14580094)
2003
38
Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles. (12164310)
2002
39
High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors. (11675336)
2001
40
Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Inhibition of glutathione S-transferase p1-1 by glutathione conjugates from anthracyclines. (11108808)
2000
41
Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells. (10453042)
1999
42
Loss of HBsAg with interferon-alpha therapy in chronic hepatitis D virus infection. (8492101)
1993
43
Repair of ribosomal RNA genes in hamster cells after UV irradiation, or treatment with cisplatin or alkylating agents. (8353843)
1993
44
Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses. (1478706)
1992
45
3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: review of 18 reported patients. (3063529)
1988
46
Mycoplasmas isolated from goats and sheep with pleuropneumonia in Saudi Arabia. (4089970)
1985
47
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. (7057924)
1982
48
Frontometaphyseal dysplasia: autosomal dominant or X-linked? (7189217)
1980
49
A new cause of mononeuropathy multiplex. (14450)
1977
50
Progressive hypersplenism after portacaval anastomosis. Report of 3 cases. (6017998)
1967

Variations for Acquired Von Willebrand Syndrome

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Expression for genes affiliated with Acquired Von Willebrand Syndrome

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Search GEO for disease gene expression data for Acquired Von Willebrand Syndrome.

Pathways for genes affiliated with Acquired Von Willebrand Syndrome

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GO Terms for genes affiliated with Acquired Von Willebrand Syndrome

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Biological processes related to Acquired Von Willebrand Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00075979.4F8, GP1BA
2blood coagulationGO:00075969.0F8, GP1BA

Sources for Acquired Von Willebrand Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet