MCID: ACQ017
MIFTS: 36

Acquired Von Willebrand Syndrome malady

Blood diseases category

Summaries for Acquired Von Willebrand Syndrome

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Acquired von willebrand syndrome (avws) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a vwf gene mutation. it is most often seen in persons over age 40 years with no prior bleeding history. this condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. about 300 cases of this condition have been reported in the medical literature thus far. treatment depends on the underlying cause of the condition. last updated: 9/15/2011

MalaCards: Acquired Von Willebrand Syndrome, also known as acquired von willebrand disease, is related to hypothyroidism and lupus erythematosus. An important gene associated with Acquired Von Willebrand Syndrome is VWF (von Willebrand factor), and among its related pathways are Integrin alphaIIb beta3 signaling and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds warfarin and adp have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are cardiovascular system and nervous system.

Aliases & Classifications for Acquired Von Willebrand Syndrome

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42NIH Rare Diseases, 48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
acquired von willebrand syndrome:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

acquired von willebrand syndrome 42 48
acquired von willebrand disease 42 48
willebrand disease, acquired 42


External Ids:

ICD10 via Orphanet26 D68.4
SNOMED-CT via Orphanet57 234451005
UMLS via Orphanet61 C0272362

Related Diseases for Acquired Von Willebrand Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Acquired Von Willebrand Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.8F8, VWF
2lupus erythematosus30.6CD40LG, F3, F2
3systemic lupus erythematosus30.6F8, CD40LG, F3, VWF, F2
4autoimmune hemolytic anemia30.5CD40LG
5myeloma30.5CD40LG
6hemolytic anemia30.5VWF, F3
7angiodysplasia30.3VWF
8cryoglobulinemia30.3CD40LG
9leukemia30.3F8, F11, CD40LG
10thrombocytosis30.3F2, VWF, F3
11hypertrophic cardiomyopathy10.5
12multiple myeloma10.4
13erythromelalgia10.2
14aortic disease10.2
15collagen disease10.2
16congenital mesoblastic nephroma10.2
17hepatocellular carcinoma10.2
18pericardial effusion10.2
19polycythemia vera10.2
20thyroid lymphoma10.2
21noonan syndrome10.2
22gastric lymphoma10.2
23monoclonal gammopathy of uncertain significance10.2
24patent ductus arteriosus10.2
25acquired polycythemia10.2
26amyloidosis10.2
27aortic valve stenosis10.2
28autosomal dominant disease10.2
29melanoma10.2
30nephroblastoma10.2
31polycythemia10.2
32sarcoma10.2
33skin melanoma10.2
34thyroiditis10.2
35hemophilia10.2
36hemolytic-uremic syndrome10.0VWF
37hellp syndrome10.0VWF
38coronary heart disease10.0VWF
39sickle cell disease10.0VWF
40essential hypertension10.0VWF
41uremia10.0VWF
42hypercholesterolemia10.0F8
43thrombophlebitis10.0F8
44hypertension10.0F2
45acquired immunodeficiency syndrome10.0F8
46hemangioma10.0F8
47cystic fibrosis10.0F8
48protein c deficiency10.0F2
49intermittent claudication10.0VWF
50peritonitis10.0F2

Graphical network of the top 20 diseases related to Acquired Von Willebrand Syndrome:



Diseases related to acquired von willebrand syndrome

Clinical Features for Acquired Von Willebrand Syndrome

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Drugs & Therapeutics for Acquired Von Willebrand Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Acquired Von Willebrand Syndrome

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Anatomical Context for Acquired Von Willebrand Syndrome

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32MalaCards
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MalaCards organs/tissues related to Acquired Von Willebrand Syndrome:

32
Heart

Animal Models for Acquired Von Willebrand Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acquired Von Willebrand Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8F11, CD40LG, F3, F2
2MP:00036317.6F2, VWF, F3, CD40LG, F11
3MP:00053977.2F2, VWF, F3, CD40LG, F11, F8
4MP:00053877.2F8, F11, CD40LG, F3, VWF, F2
5MP:00053767.1F8, F11, CD40LG, F3, VWF, F2
6MP:00107687.0F8, F11, CD40LG, F3, VWF, F2

Publications for Acquired Von Willebrand Syndrome

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Genetic Variations for Acquired Von Willebrand Syndrome

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Expression for genes affiliated with Acquired Von Willebrand Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acquired Von Willebrand Syndrome

Search GEO for disease gene expression data for Acquired Von Willebrand Syndrome.

Pathways for genes affiliated with Acquired Von Willebrand Syndrome

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53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Acquired Von Willebrand Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Acquired Von Willebrand Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.5VWF
2adp44 28 2412.2CD40LG
3recombinate449.9F8, VWF
4tributylphosphate449.8VWF, F8
5kogenate449.8F8, VWF
6deae-sephadex a-50449.7F2, F8
7dextran sulfate449.7F11, CD40LG
8brodifacoum449.5F2, F3
9napsagatran449.5F3, F2
10aprosulate449.5F3, F2
11hemochron449.4F3, F2
12certoparin449.4F2, F3
13Coagulation Factor IX119.4F2, F8, F11
14appt449.4F3, F2
15heparin sodium449.3F2, F3
16heparin44 28 11 2412.3CD40LG, F11, F8
17inogatran449.3F3, F2
18ecarin449.2F3, F2
19aspartate449.2F2, CD40LG, F8
20aprotinin44 1110.2VWF, F3, F11
21dextran 70449.1F2, F3
22spectrozyme449.1F2, F3
23ivig449.1F8, CD40LG, VWF
24rituximab44 49 1111.0CD40LG, F8, VWF
25dipyridamole44 59 28 1112.0F3, VWF, F2
26kaolin449.0F3, F2, F8
27dermatan sulfate448.7VWF, F2, F11, F3
28kininogen448.7F11, F3, F2, VWF
29hydroxyethyl starch448.6F8, F3, F2, VWF
30tranexamic acid44 119.6F8, F3, VWF, F2
31citrate448.6F8, F3, F2, VWF
32ppack448.5F2, VWF, CD40LG, F3
33tirofiban44 119.5F2, VWF, CD40LG, F3
34abciximab44 119.5CD40LG, F2, VWF, F3
35clopidogrel49 44 11 2411.5F2, CD40LG, F3, VWF
36polyethylene glycol448.5F8, CD40LG, F2
37endotoxin448.4F3, F8, CD40LG, F11
38cyclosporin a44 28 5910.3F8, F2, CD40LG, VWF
39ristocetin448.2F3, VWF, F8, F11, F2
40desmopressin44 59 28 1111.2F2, VWF, F3, F11, F8
41homocysteine44 249.2F3, VWF, F11, F8, F2
42phospholipid448.1F2, VWF, F11, F3, F8
43phosphatidylserine44 28 1110.0F2, CD40LG, VWF, F3, F8
44aspirin44 49 28 2411.0F2, VWF, F3, CD40LG, F8
45epinephrine44 11 2410.0F2, F8, CD40LG, F3, VWF
46creatinine448.0F8, CD40LG, F3, VWF, F2
47alanine447.9F3, F8, CD40LG, F2, VWF
48hirudin447.6CD40LG, F8, F2, F11, VWF, F3
49fibrinogen447.6F2, F8, F11, VWF, CD40LG, F3
50serine447.5VWF, F2, F8, CD40LG, F11, F3

GO Terms for genes affiliated with Acquired Von Willebrand Syndrome

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16Gene Ontology
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Cellular components related to Acquired Von Willebrand Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5VWF, F8
2extracellular spaceGO:0056157.2F2, F3, CD40LG, F11, F8

Biological processes related to Acquired Von Willebrand Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.5F2, VWF
2acute-phase responseGO:0069539.1F2, F8
3blood coagulation, intrinsic pathwayGO:0075978.6F2, VWF, F11, F8
4platelet activationGO:0301688.3F8, CD40LG, VWF, F2
5blood coagulationGO:0075967.7F8, F11, F3, VWF, F2

Molecular functions related to Acquired Von Willebrand Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2VWF, F3

Products for genes affiliated with Acquired Von Willebrand Syndrome

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Sources for Acquired Von Willebrand Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet