MCID: ACQ017
MIFTS: 36

Acquired Von Willebrand Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Acquired Von Willebrand Syndrome

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Sources:
45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acquired Von Willebrand Syndrome:

Name: Acquired Von Willebrand Syndrome 45 51
Acquired Von Willebrand Disease 45 51
 
Willebrand Disease, Acquired 45

Characteristics:

Orphanet epidemiological data:

51
acquired von willebrand syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet51 99147
ICD10 via Orphanet28 D68.4
UMLS via Orphanet66 C0272362

Summaries for Acquired Von Willebrand Syndrome

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NIH Rare Diseases:45 Acquired von willebrand syndrome (avws) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a vwf gene mutation. it is most often seen in persons over age 40 years with no prior bleeding history. this condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. about 300 cases of this condition have been reported in the medical literature thus far. treatment depends on the underlying cause of the condition. last updated: 9/15/2011

MalaCards based summary: Acquired Von Willebrand Syndrome, also known as acquired von willebrand disease, is related to heart disease and congenital heart disease. An important gene associated with Acquired Von Willebrand Syndrome is VWF (Von Willebrand Factor), and among its related pathways are Complement and coagulation cascades and Platelet activation. Affiliated tissues include heart, breast and bone, and related mouse phenotype hematopoietic system.

Related Diseases for Acquired Von Willebrand Syndrome

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Diseases related to Acquired Von Willebrand Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1heart disease10.2
2congenital heart disease10.2
3hypothyroidism10.2
4cardiomyopathy10.2
5systemic lupus erythematosus10.1
6lymphoma10.1
7polycythemia10.1
8lupus erythematosus10.1
9megakaryocytic tumor10.1JAK2, VWF
10type 2n von willebrand disease10.1F8, VWF
11tyrobp-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy10.1F8, VWF
12severe hemophilia a10.1F8, VWF
13von willibrand disease, type 310.1F8, VWF
14multiple myeloma10.0
15hemolytic anemia10.0
16leukemia10.0
17myeloma10.0
18angiodysplasia10.0
19autoimmune hemolytic anemia10.0
20essential thrombocythemia10.0
21benign pericardial teratoma10.0F8, VWF
22dysthymic disorder10.0F8, VWF
23skeletal muscle regeneration10.0F8, VWF
24heterotopia, periventricular10.0F8, VWF
25myoma10.0F8, VWF
26thumb absent short stature immune deficiency9.9F8, VWF
27thrombophilia due to activated protein c resistance9.9F8, VWF
28agammaglobulinemia x-linked type 29.9F8, VWF
29ewing sarcoma9.9
30chronic lymphocytic leukemia9.9
31myelofibrosis9.9
32lymphoplasmacytic lymphoma9.9
33sarcoma9.9
34pancytopenia9.9
35patent ductus arteriosus9.9
36melanoma9.9
37thrombocytosis9.9
38thyroiditis9.9
39monoclonal gammopathy of uncertain significance9.9
40amyloidosis9.9
41al amyloidosis9.9
42hemophilia a9.9
43split-hand/foot malformation with long bone deficiency 39.9GP1BA, VWF
44acquired thrombocytopenia9.9GP1BA, VWF
45pregnancy loss, recurrent 29.8F8, VWF
46learning disability9.8GP1BA, VWF
47ewing's family of tumors9.8JAK2, VWF
48transient refractive change9.8GP1BA, VWF
49hemophilia9.7
50type 2a von willebrand disease9.7

Graphical network of the top 20 diseases related to Acquired Von Willebrand Syndrome:



Diseases related to acquired von willebrand syndrome

Symptoms for Acquired Von Willebrand Syndrome

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Drugs & Therapeutics for Acquired Von Willebrand Syndrome

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Drugs for Acquired Von Willebrand Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Natriuretic AgentsPhase 41403
2VasopressinsPhase 4260
3HemostaticsPhase 41082
4Deamino Arginine VasopressinPhase 468
5Arginine VasopressinPhase 4264
6CoagulantsPhase 41042
7arginineNutraceuticalPhase 4364

Interventional clinical trials:

idNameStatusNCT IDPhase
1Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement SurgeryCompletedNCT01994330Phase 4
2Acquired Von Willebrand Syndrome in Severe Aortic StenosisCompletedNCT00805051
3ADAMTS13 in Thrombotic Thrombocytopenic PurpuraCompletedNCT00426686

Search NIH Clinical Center for Acquired Von Willebrand Syndrome

Genetic Tests for Acquired Von Willebrand Syndrome

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Anatomical Context for Acquired Von Willebrand Syndrome

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MalaCards organs/tissues related to Acquired Von Willebrand Syndrome:

33
Heart, Breast, Bone, Skin, Tongue, Endothelial, Prostate

Animal Models for Acquired Von Willebrand Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Acquired Von Willebrand Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0F8, GP1BA, JAK2, VWF

Publications for Acquired Von Willebrand Syndrome

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Articles related to Acquired Von Willebrand Syndrome:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Distinct mechanisms account for acquired von Willebrand syndrome in plasma cell dyscrasias. (27040683)
2016
2
Lenalidomide as a novel treatment for refractory Acquired von Willebrand Syndrome associated with monoclonal gammopathy. (26991062)
2016
3
Impact of Acquired von Willebrand Syndrome in Severe Aortic Stenosis. (26370453)
2015
4
Unexpectedly High Prevalence of Acquired von Willebrand Syndrome in Patients with Severe Aortic Stenosis as Evaluated with a Novel Large Multimer Index. (26269004)
2015
5
Acquired von Willebrand Syndrome (AVWS) as an Important Diagnostic Category of Disease. (25740338)
2015
6
Autophagy: A potential link between Acquired von Willebrand syndrome and congenital heart disease. (25804464)
2015
7
Treatment of acquired von Willebrand syndrome in aortic stenosis with transcatheter aortic valve replacement. (25946442)
2015
8
Acquired von Willebrand syndrome in a case of polycythemia vera resulting in recurrent and massive bleeding events in the pleural and abdominal cavity. (25215616)
2014
9
Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device. (24720921)
2014
10
Correction of acquired von Willebrand syndrome by transcatheter aortic valve implantation. (25480995)
2014
11
An atypical manifestation of acquired von Willebrand syndrome (AVWS) associated with systemic lupus erythematosus (SLE). (23625134)
2014
12
Development of acquired von Willebrand syndrome during short-term micro axial pump support: implications for bleeding in a patient bridged to a long-term continuous-flow left ventricular assist device. (24614358)
2014
13
Current diagnostic and therapeutic approaches to patients with acquired von Willebrand syndrome: a 2013 update. (23397553)
2013
14
Acquired von Willebrand syndrome in patients with Gaucher disease. (24275154)
2013
15
Acquired von Willebrand Syndrome with a Type 2B Phenotype: Diagnostic and Therapeutic Dilemmas. (24296552)
2013
16
Acquired von Willebrand syndrome in a patient with monoclonal gammopathy of undetermined significance. (23249617)
2013
17
Acquired von Willebrand syndrome: a rare disorder of heterogeneous etiology. (23793308)
2013
18
Hematological evaluation of acquired von Willebrand syndrome before oral surgery: Management of an unusual case. (22623844)
2012
19
Diagnosis and treatment of acquired von Willebrand syndrome. (23439003)
2012
20
Acquired Von Willebrand syndrome is an early-onset problem in ventricular assist device patients. (21515067)
2011
21
Hypertrophic obstructive cardiomyopathy, acquired von Willebrand syndrome, and gastrointestinal bleeding. (21364110)
2011
22
Acquired von Willebrand syndrome associated with monoclonal gammopathy: a single-center study of 36 patients. (22033454)
2011
23
Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. (20868825)
2010
24
Acquired von Willebrand syndrome in patients with ventricular assist device or total artificial heart. (20352153)
2010
25
Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device. (20739614)
2010
26
Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation. (20598466)
2010
27
Bortezomib effectiveness in one patient with acquired von Willebrand syndrome associated to monoclonal gammopathy of undetermined significance. (20425807)
2010
28
Mechanisms underlying acquired von Willebrand syndrome associated with an IgM paraprotein. (19572993)
2009
29
Acquired von Willebrand syndrome in cardiac patients. (18922429)
2008
30
Acquired von Willebrand syndrome. (18445010)
2008
31
Association of acquired von Willebrand syndrome with AL amyloidosis. (17205535)
2007
32
Cefotaxime as the potential cause of transient acquired von Willebrand syndrome. (16529605)
2006
33
Paediatric acquired von Willebrand syndrome. (16643216)
2006
34
Acquired von Willebrand syndrome: features and management. (16823821)
2006
35
Acquired von Willebrand syndrome in a patient with Ewing sarcoma. (16651239)
2006
36
A case of acquired von Willebrand syndrome successfully treated with recombinant Factor VIIa during thyroidectomy. (15457604)
2004
37
Acquired von Willebrand syndrome 2004: International Registry--diagnosis and management from online to bedside. (15029273)
2004
38
Acquired von Willebrand syndrome with autoimmune hemolytic anemia]. (15103936)
2004
39
Acquired von Willebrand syndrome: its pathophysiology, laboratory features and management. (14739623)
2003
40
Diagnosis and management of acquired von Willebrand syndrome. (16224398)
2003
41
Acquired von Willebrand syndrome in children with patent ductus arteriosus. (12067958)
2002
42
Acquired von Willebrand syndrome: experience from 2 years in a single laboratory compared with data from the literature and an international registry. (11992245)
2002
43
Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management. (11686107)
2001
44
Therapeutic approaches to acquired von Willebrand syndrome. (11060681)
2000
45
Effectiveness of high-dose intravenous immunoglobulin in a case of acquired von Willebrand syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate. (1415174)
1992
46
Acquired von Willebrand syndrome with autoimmune hemolytic anemia]. (2246822)
1990
47
The use of high-dose intravenous gamma-globulin in acquired von Willebrand syndrome. (2447856)
1988
48
Acquired von Willebrand syndrome due to an inhibitor specific for von Willebrand factor antigens. (3080872)
1986
49
Pathogenesis of antibody-induced acquired von Willebrand Syndrome. (6782864)
1980
50
Acquired von Willebrand syndrome with inhibitors both to factor VIII clotting activity and ristocetin-induced platelet aggregation. (1087568)
1976

Variations for Acquired Von Willebrand Syndrome

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Expression for genes affiliated with Acquired Von Willebrand Syndrome

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Search GEO for disease gene expression data for Acquired Von Willebrand Syndrome.

Pathways for genes affiliated with Acquired Von Willebrand Syndrome

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GO Terms for genes affiliated with Acquired Von Willebrand Syndrome

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Biological processes related to Acquired Von Willebrand Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00075979.4F8, GP1BA
2blood coagulationGO:00075969.0F8, GP1BA

Sources for Acquired Von Willebrand Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet