ALM
MCID: ACR014
MIFTS: 47

Acral Lentiginous Melanoma (ALM) malady

Rare diseases, Cancer diseases, Skin diseases categories

Summaries for Acral Lentiginous Melanoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

MalaCards: Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and sarcoma. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Renal cell carcinoma and Cell adhesion Cell matrix glycoconjugates. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Acral Lentiginous Melanoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

acral lentiginous melanoma 9 44 11
acral lentiginous malignant melanoma of skin 44
acral lentiginous melanoma, malignant 9
acral lentiginous malignant melanoma 63
malignant acral lentiginous melanoma 9
palmar/plantar melanoma 44
subungual melanoma 44
alm 44


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Disease Ontology9 DOID:6367

Related Diseases for Acral Lentiginous Melanoma

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18GeneCards, 19GeneDecks
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Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.6CSPG4, CDKN2A, NRAS, MET, KRT9, ANKRD36B
2sarcoma30.4MUC1, MET, NRAS, VIM
3tinea nigra10.3
4lichen planus10.3
5clear cell sarcoma10.3
6psoriatic arthritis10.3
7tinea pedis10.3
8arthritis10.3
9basal cell carcinoma10.3
10multiple myeloma10.3
11myeloma10.3
12tuberculosis10.3
13lentigo maligna melanoma10.3
14lichen planus pigmentosus10.3
15alstrom syndrome10.2
16lupus nephritis10.2
17nephritis10.2
18pyogenic granuloma10.1
19eccrine porocarcinoma10.1MUC1
20hidradenoma10.1MUC1
21syringoma10.1MUC1
22cystadenocarcinoma10.1MUC1
23adenomatoid tumor10.1VIM
24glomus tumor10.1VIM
25chordoma10.1VIM, MUC1
26clear cell ependymoma10.1VIM, MUC1
27mesenchymal chondrosarcoma10.1VIM, MUC1
28spindle cell carcinoma10.1MUC1, VIM
29spindle cell sarcoma10.1MUC1, VIM
30epithelioid sarcoma10.1MUC1, VIM
31sertoli cell tumor10.0MUC1, VIM
32secretory meningioma10.0MUC1, VIM
33dermatofibrosarcoma protuberans10.0MUC1, VIM
34perineurioma10.0VIM, MUC1
35rhabdoid tumor10.0VIM, MUC1
36sex cord-gonadal stromal tumor10.0VIM, MUC1
37hemangiopericytoma10.0VIM, MUC1
38malignant mixed mullerian tumor10.0VIM, MUC1
39angiosarcoma10.0MUC1, VIM
40abrikosov's tumor10.0MUC1, VIM
41giant cell tumor10.0MUC1, VIM
42pleomorphic adenoma10.0VIM, MUC1
43neuronitis10.0
44malignant fibroxanthoma10.0MUC1, VIM
45adenoid cystic carcinoma10.0VIM, MUC1
46malignant pleural mesothelioma10.0MUC1, MET
47ependymoma10.0VIM, MUC1
48oxyphilic adenoma10.0MUC1, VIM
49proliferative vitreoretinopathy10.0TFRC, MET
50leiomyosarcoma10.0MUC1, VIM

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Symptoms for Acral Lentiginous Melanoma

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Drugs & Therapeutics for Acral Lentiginous Melanoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acral Lentiginous Melanoma

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Anatomical Context for Acral Lentiginous Melanoma

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34MalaCards
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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

34
Skin, Lymph node

Animal Models for Acral Lentiginous Melanoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MUC1, MET, NRAS, KRT9, CDKN2A
2MP:00053818.6CDKN2A, NRAS, MET, MUC1, TFRC
3MP:00030128.5MUC1, MET, CSPG4, NRAS, CDKN2A
4MP:00053918.4VIM, MUC1, MET, NRAS, CDKN2A
5MP:00053808.4CDKN2A, NRAS, MET, VIM, TFRC
6MP:00107718.4TFRC, MUC1, NRAS, KRT9, CDKN2A
7MP:00053708.3CDKN2A, NRAS, CSPG4, MET, MUC1, TFRC
8MP:00053847.8TFRC, VIM, MET, CSPG4, NRAS, KRT9
9MP:00053877.8TFRC, VIM, MET, CSPG4, NRAS, CDKN2A
10MP:00053787.7TFRC, VIM, MET, CSPG4, NRAS, KRT9
11MP:00053767.7TFRC, VIM, MUC1, MET, CSPG4, NRAS

Publications for Acral Lentiginous Melanoma

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53PubMed
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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
2
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? (24249911)
2013
3
KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma. (23993026)
2013
4
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. (22157852)
2012
5
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. (21732773)
2011
6
The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma). (21167406)
2011
7
Acral lentiginous melanoma. (21549241)
2011
8
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
9
Acral lentiginous melanoma: a case control study and guidelines update. (21541184)
2011
10
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
11
Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma. (20466190)
2010
12
Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. (18758972)
2009
13
Progression from Acral Lentiginous Melanoma in situ to Invasive Acral Lentiginous Melanoma. (20523783)
2009
14
Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. (19380664)
2009
15
Expression of p16 protein in acral lentiginous melanoma. (20415670)
2009
16
Acral lentiginous melanoma: conventional histology vs. three-dimensional histology. (19067697)
2009
17
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. (18822168)
2008
18
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
19
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
20
Acral lentiginous melanoma: histopathological prognostic features of 121 cases. (17596173)
2007
21
Acral lentiginous melanoma in situ: a study of nine cases. (15249858)
2004
22
Acral lentiginous melanoma: an immunohistochemical study of 20 cases. (12709000)
2003
23
Acral lentiginous melanoma mimicking benign disease: the Emory experience. (12582386)
2003
24
Acral-lentiginous melanoma. (10881468)
2000
25
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
26
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
27
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. (10434891)
1999
28
Acral lentiginous melanoma. (9879051)
1998
29
Distinctive dermatoscopic features of acral lentiginous melanoma in situ from plantar melanocytic nevi and their histopathologic correlation. (9558302)
1998
30
Plantar flap reconstruction for acral lentiginous melanoma. (9367024)
1997
31
Acral lentiginous melanoma of the palm. (9136165)
1996
32
Acral lentiginous melanoma. (8328633)
1993
33
Acral lentiginous melanoma associated with Down's syndrome. (8482754)
1993
34
Acral lentiginous melanoma: case studies from Kauai. (1428854)
1992
35
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
36
The current management and prognosis of acral lentiginous melanoma. (1642394)
1992
37
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
38
Improved survival rates of patients with acral lentiginous melanoma treated with hyperthermic isolation perfusion, wide excision, and regional lymphadenectomy. (3518512)
1986
39
Pigmented freckles on the sole of acral lentiginous melanoma in situ. (3908530)
1985
40
Acral lentiginous melanoma and its precursor--heterogeneity of palmo-plantar melanomas. (4047728)
1985
41
Acral lentiginous melanoma: an illustrative case report and brief review of the literature. (6498406)
1984
42
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
43
Acral lentiginous melanoma and lentigo maligna occurring in Werner's syndrome. (6627991)
1983
44
Acral lentiginous melanoma. A clinicopathologic study of 36 patients. (6850538)
1983
45
Acral lentiginous melanoma in situ. (7122752)
1982
46
Acral lentiginous melanoma of the penis. (7075635)
1982
47
Dermatology-epitomes of progress: acral lentiginous melanoma. (18748764)
1981
48
Acral lentiginous melanoma. (7389397)
1980
49
Acral lentiginous melanoma. (7396539)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Variations for Acral Lentiginous Melanoma

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Expression for genes affiliated with Acral Lentiginous Melanoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

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51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NRAS, MET
29.6CSPG4, MUC1
39.3CDKN2A, NRAS, MET
4
Show member pathways
Signaling Pathways in Glioblastoma39
9.3MET, NRAS, CDKN2A
58.8CDKN2A, NRAS, MET, VIM
6
Show member pathways
8.4VIM, MUC1, MET, NRAS, CDKN2A

Compounds for genes affiliated with Acral Lentiginous Melanoma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1eosin4610.0MUC1, VIM
2s 1004610.0MUC1, VIM
3reticulin4610.0MUC1, VIM
4mucicarmine4610.0MUC1, VIM
5fluorochrome469.9VIM, TFRC
6b 723469.8VIM, MUC1
7k252a469.8VIM, MET
8temozolomide46 1210.8VIM, CDKN2A
9crcs469.7MUC1, MET, CDKN2A
10leupeptin469.7VIM, TFRC
11doxycycline46 1210.6CDKN2A, TFRC
12dmso469.6TFRC, VIM, MUC1
13hematoxylin469.6CDKN2A, MUC1, VIM
14roscovitine469.5CDKN2A, VIM
15matrigel469.5MET, MUC1, VIM
16methotrexate52 46 1211.5CDKN2A, MUC1, VIM
17chloramphenicol46 3 52 1212.5VIM, MUC1, CDKN2A
1812-o-tetradecanoylphorbol 13-acetate469.5MET, MUC1, VIM
19vitamin d469.4MET, VIM, TFRC
20rapamycin469.3MET, VIM, TFRC
21paclitaxel46 52 1211.3TFRC, VIM, CDKN2A
22wortmannin469.3TFRC, VIM, MET
23cisplatin46 52 62 1212.3TFRC, MUC1, MET, CDKN2A
24glycogen46 2510.3VIM, MUC1, MET
25biotin46 25 1211.2CDKN2A, MUC1, VIM, TFRC
26cytarabine46 52 1211.2TFRC, VIM, MUC1, CDKN2A
27folate469.2CDKN2A, MUC1, VIM, TFRC
28butyrate469.2TFRC, VIM, MUC1, CDKN2A
29glutamine469.2TFRC, VIM, KRT9
30creatinine469.2CDKN2A, MUC1, VIM, TFRC
31doxorubicin46 52 1211.1TFRC, VIM, MET, CDKN2A
32genistein46 30 62 3 25 1214.1CDKN2A, MET, VIM, TFRC
33progesterone46 30 62 25 1213.1VIM, MUC1, MET, CDKN2A
34dexamethasone46 52 30 1212.1TFRC, VIM, MUC1, CDKN2A
35oligonucleotide469.1CDKN2A, NRAS, MET, VIM
36cycloheximide469.1TFRC, VIM, MET, CDKN2A
37alanine469.0TFRC, VIM, MET, CDKN2A
38agar468.9VIM, MUC1, MET, NRAS, CDKN2A
39arginine468.8TFRC, VIM, MET, KRT9, CDKN2A
40iron46 259.8CDKN2A, VIM, TFRC
41adriamycin468.8CDKN2A, MET, MUC1, VIM, TFRC
42actinomycin d468.8TFRC, VIM, MUC1, MET, CDKN2A
43paraffin468.8TFRC, VIM, MUC1, MET, CDKN2A
44testosterone46 62 25 1211.8CDKN2A, MET, MUC1, VIM, TFRC
45vegf468.8CDKN2A, MET, MUC1, VIM, TFRC
46estrogen468.8TFRC, VIM, MUC1, MET, CDKN2A
47retinoic acid46 259.8TFRC, VIM, MUC1, MET, CDKN2A
48cysteine468.8TFRC, VIM, MUC1, MET, CDKN2A
49serine468.7TFRC, VIM, MUC1, MET, CDKN2A

GO Terms for genes affiliated with Acral Lentiginous Melanoma

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17Gene Ontology
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Cellular components related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.2CSPG4, MUC1, TFRC
2integral component of plasma membraneGO:0058878.5TFRC, MUC1, MET, CSPG4
3extracellular vesicular exosomeGO:0700628.5KRT9, NRAS, MUC1, VIM, TFRC

Biological processes related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.7KRT9, VIM

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.7CDKN2A, MUC1
2double-stranded RNA bindingGO:0037259.3VIM, TFRC

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet