MCID: ACR014
MIFTS: 41

Acral Lentiginous Melanoma malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Acral Lentiginous Melanoma

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Acral Lentiginous Melanoma, Aliases & Descriptions:

Name: Acral Lentiginous Melanoma 9 41 11
Acral Lentiginous Malignant Melanoma of Skin 41
Acral Lentiginous Melanoma, Malignant 9
Malignant Acral Lentiginous Melanoma 9
 
Acral Lentiginous Malignant Melanoma 60
Palmar/plantar Melanoma 41
Subungual Melanoma 41
Alm 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:6367

Summaries for Acral Lentiginous Melanoma

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Disease Ontology:9 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

MalaCards based summary: Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and sarcoma. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Renal cell carcinoma and Cell adhesion Cell matrix glycoconjugates. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:63 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

Related Diseases for Acral Lentiginous Melanoma

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Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.4CSPG4, CDKN2A, NRAS, MET, KRT9, ANKRD36B
2sarcoma30.2MUC1, MET, NRAS, VIM
3eccrine porocarcinoma10.4MUC1
4hidradenoma10.4MUC1
5syringoma10.4MUC1
6cystadenocarcinoma10.4MUC1
7adenomatoid tumor10.4VIM
8glomus tumor10.4VIM
9renal cell carcinoma10.4MET
10psoriatic arthritis10.3
11multiple myeloma10.3
12arthritis10.3
13tinea nigra10.3
14lichen planus10.3
15clear cell sarcoma10.3
16tinea pedis10.3
17basal cell carcinoma10.3
18laryngitis10.3
19myeloma10.3
20tuberculosis10.3
21lentigo maligna melanoma10.3
22lichen planus pigmentosus10.3
23chordoma10.2VIM, MUC1
24clear cell ependymoma10.2VIM, MUC1
25mesenchymal chondrosarcoma10.2VIM, MUC1
26spindle cell carcinoma10.2MUC1, VIM
27spindle cell sarcoma10.2MUC1, VIM
28epithelioid sarcoma10.2MUC1, VIM
29sertoli cell tumor10.2MUC1, VIM
30secretory meningioma10.2MUC1, VIM
31dermatofibrosarcoma protuberans10.2MUC1, VIM
32perineurioma10.2VIM, MUC1
33rhabdoid tumor10.2VIM, MUC1
34alstrom syndrome10.2
35lupus nephritis10.2
36nephritis10.2
37sex cord-gonadal stromal tumor10.2VIM, MUC1
38hemangiopericytoma10.2VIM, MUC1
39malignant mixed mullerian tumor10.2VIM, MUC1
40angiosarcoma10.2MUC1, VIM
41abrikosov's tumor10.2MUC1, VIM
42giant cell tumor10.2MUC1, VIM
43pleomorphic adenoma10.1VIM, MUC1
44malignant fibroxanthoma10.1MUC1, VIM
45pyogenic granuloma10.1
46salivary gland adenoid cystic carcinoma10.1VIM, MUC1
47malignant pleural mesothelioma10.1MUC1, MET
48ependymoma10.1VIM, MUC1
49oxyphilic adenoma10.1MUC1, VIM
50vitreoretinopathy, neovascular inflammatory10.1TFRC, MET

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Symptoms for Acral Lentiginous Melanoma

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Drugs & Therapeutics for Acral Lentiginous Melanoma

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Drug clinical trials:

Search ClinicalTrials for Acral Lentiginous Melanoma

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

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Anatomical Context for Acral Lentiginous Melanoma

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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

31
Skin, Lymph node

Animal Models for Acral Lentiginous Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MET, MUC1, NRAS, KRT9, CDKN2A
2MP:00053818.6CDKN2A, MET, MUC1, TFRC, NRAS
3MP:00030128.5CDKN2A, CSPG4, MET, MUC1, NRAS
4MP:00053918.4CDKN2A, VIM, MUC1, MET, NRAS
5MP:00053808.4TFRC, VIM, NRAS, CDKN2A, MET
6MP:00107718.4CDKN2A, KRT9, NRAS, MUC1, TFRC
7MP:00053708.3MUC1, MET, CSPG4, NRAS, TFRC, CDKN2A
8MP:00053847.8NRAS, TFRC, VIM, MET, CSPG4, KRT9
9MP:00053877.8CDKN2A, TFRC, CSPG4, NRAS, VIM, MET
10MP:00053787.7NRAS, KRT9, CSPG4, MET, VIM, CDKN2A
11MP:00053767.7VIM, MUC1, CDKN2A, NRAS, CSPG4, TFRC

Publications for Acral Lentiginous Melanoma

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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? (25455840)
2015
2
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. (25773399)
2015
3
TERT promoter mutation is uncommon in acral lentiginous melanoma. (24588324)
2014
4
Recurrent acral lentiginous melanoma in situ suggesting the field cell theory. (25473243)
2014
5
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. (25396085)
2014
6
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
7
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? (24249911)
2013
8
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. (22157852)
2012
9
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. (21732773)
2011
10
The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma). (21167406)
2011
11
Acral lentiginous melanoma. (21549241)
2011
12
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
13
Acral lentiginous melanoma: a case control study and guidelines update. (21541184)
2011
14
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
15
Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma. (20466190)
2010
16
Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. (18758972)
2009
17
Progression from Acral Lentiginous Melanoma in situ to Invasive Acral Lentiginous Melanoma. (20523783)
2009
18
Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. (19380664)
2009
19
Expression of p16 protein in acral lentiginous melanoma. (20415670)
2009
20
Acral lentiginous melanoma: conventional histology vs. three-dimensional histology. (19067697)
2009
21
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. (18822168)
2008
22
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
23
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
24
Acral lentiginous melanoma: histopathological prognostic features of 121 cases. (17596173)
2007
25
Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. (17083858)
2006
26
Acral lentiginous melanoma in situ: a study of nine cases. (15249858)
2004
27
Acral lentiginous melanoma: an immunohistochemical study of 20 cases. (12709000)
2003
28
Acral lentiginous melanoma mimicking benign disease: the Emory experience. (12582386)
2003
29
Acral-lentiginous melanoma. (10881468)
2000
30
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
31
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
32
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. (10434891)
1999
33
Acral lentiginous melanoma. (9879051)
1998
34
Plantar flap reconstruction for acral lentiginous melanoma. (9367024)
1997
35
Acral lentiginous melanoma of the palm. (9136165)
1996
36
Acral lentiginous melanoma. (8328633)
1993
37
Acral lentiginous melanoma associated with Down's syndrome. (8482754)
1993
38
Acral lentiginous melanoma: case studies from Kauai. (1428854)
1992
39
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
40
The current management and prognosis of acral lentiginous melanoma. (1642394)
1992
41
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
42
Pigmented freckles on the sole of acral lentiginous melanoma in situ. (3908530)
1985
43
Acral lentiginous melanoma: an illustrative case report and brief review of the literature. (6498406)
1984
44
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
45
Acral lentiginous melanoma and lentigo maligna occurring in Werner's syndrome. (6627991)
1983
46
Acral lentiginous melanoma in situ. (7122752)
1982
47
Acral lentiginous melanoma of the penis. (7075635)
1982
48
Dermatology-epitomes of progress: acral lentiginous melanoma. (18748764)
1981
49
Acral lentiginous melanoma. (7389397)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Variations for Acral Lentiginous Melanoma

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Expression for genes affiliated with Acral Lentiginous Melanoma

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Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

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Pathways related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NRAS, MET
29.6CSPG4, MUC1
39.3CDKN2A, NRAS, MET
4
Show member pathways
Signaling Pathways in Glioblastoma36
9.3MET, NRAS, CDKN2A
58.8CDKN2A, NRAS, MET, VIM
6
Show member pathways
8.4VIM, MUC1, MET, NRAS, CDKN2A

Compounds for genes affiliated with Acral Lentiginous Melanoma

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Compounds related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1eosin4310.0MUC1, VIM
2s 1004310.0MUC1, VIM
3reticulin4310.0MUC1, VIM
4mucicarmine4310.0VIM, MUC1
5fluorochrome439.9TFRC, VIM
6b 723439.8MUC1, VIM
7k252a439.8VIM, MET
8temozolomide43 1210.8VIM, CDKN2A
9crcs439.7CDKN2A, MET, MUC1
10leupeptin439.7TFRC, VIM
11doxycycline43 1210.6CDKN2A, TFRC
12dmso439.6MUC1, TFRC, VIM
13hematoxylin439.6VIM, CDKN2A, MUC1
14roscovitine439.5VIM, CDKN2A
15matrigel439.5MUC1, VIM, MET
16methotrexate49 43 1211.5CDKN2A, VIM, MUC1
17chloramphenicol43 2 49 1212.5CDKN2A, MUC1, VIM
1812-o-tetradecanoylphorbol 13-acetate439.5MUC1, VIM, MET
19vitamin d439.4VIM, MET, TFRC
20rapamycin439.3VIM, MET, TFRC
21paclitaxel43 49 1211.3CDKN2A, VIM, TFRC
22wortmannin439.3TFRC, VIM, MET
23cisplatin43 49 59 1212.3CDKN2A, MET, MUC1, TFRC
24glycogen43 2410.3MET, MUC1, VIM
25biotin43 24 1211.2TFRC, VIM, MUC1, CDKN2A
26cytarabine43 49 1211.2VIM, TFRC, MUC1, CDKN2A
27folate439.2TFRC, CDKN2A, MUC1, VIM
28butyrate439.2CDKN2A, MUC1, VIM, TFRC
29glutamine439.2KRT9, TFRC, VIM
30creatinine439.2VIM, TFRC, MUC1, CDKN2A
31doxorubicin43 49 1211.1MET, VIM, TFRC, CDKN2A
32genistein43 28 59 2 24 1214.1MET, VIM, CDKN2A, TFRC
33progesterone43 28 59 24 1213.1CDKN2A, MET, MUC1, VIM
34dexamethasone43 49 28 1212.1VIM, CDKN2A, MUC1, TFRC
35oligonucleotide439.1MET, NRAS, CDKN2A, VIM
36cycloheximide439.1VIM, CDKN2A, TFRC, MET
37alanine439.0MET, TFRC, VIM, CDKN2A
38agar438.9MUC1, CDKN2A, NRAS, MET, VIM
39arginine438.8MET, VIM, TFRC, CDKN2A, KRT9
40iron43 249.8CDKN2A, VIM, TFRC
41adriamycin438.8MET, CDKN2A, MUC1, VIM, TFRC
42actinomycin d438.8CDKN2A, TFRC, VIM, MUC1, MET
43paraffin438.8CDKN2A, MUC1, VIM, TFRC, MET
44testosterone43 59 24 1211.8CDKN2A, VIM, MET, MUC1, TFRC
45vegf438.8MUC1, MET, CDKN2A, VIM, TFRC
46estrogen438.8CDKN2A, MET, MUC1, VIM, TFRC
47retinoic acid43 249.8MET, MUC1, VIM, TFRC, CDKN2A
48cysteine438.8MET, CDKN2A, TFRC, MUC1, VIM
49serine438.7MET, TFRC, MUC1, CDKN2A, VIM

GO Terms for genes affiliated with Acral Lentiginous Melanoma

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Cellular components related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.2CSPG4, MUC1, TFRC
2integral component of plasma membraneGO:00058878.5TFRC, MUC1, MET, CSPG4
3extracellular vesicular exosomeGO:00700628.5KRT9, NRAS, MUC1, VIM, TFRC

Biological processes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:00451099.7KRT9, VIM

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.7CDKN2A, MUC1
2double-stranded RNA bindingGO:00037259.3VIM, TFRC

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

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3CDC
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25ICD10
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27ICD9CM
28IUPHAR
29KEGG
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46OMIM via Orphanet
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