ALM
MCID: ACR014
MIFTS: 39

Acral Lentiginous Melanoma (ALM) malady

Summaries for Acral Lentiginous Melanoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

MalaCards: Acral Lentiginous Melanoma, also known as acral lentiginous melanoma, malignant, is related to lentigo maligna melanoma and spitz nevus. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Glioma and GPCR Pathway. The compounds creatinine and eosin have been mentioned in the context of this disorder. Affiliated tissues include lymph node and skin, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Acral Lentiginous Melanoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS
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Aliases & Descriptions:

acral lentiginous melanoma 8 43 10
acral lentiginous melanoma, malignant 8
acral lentiginous malignant melanoma 61
malignant acral lentiginous melanoma 8
palmar/plantar melanoma 43
subungual melanoma 43
alm 43


External Ids:

Disease Ontology8 DOID:6367

Related Diseases for Acral Lentiginous Melanoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Clinical Features for Acral Lentiginous Melanoma

Drugs & Therapeutics for Acral Lentiginous Melanoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Acral Lentiginous Melanoma

Search NIH Clinical Center for Acral Lentiginous Melanoma

Search CenterWatch for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

Anatomical Context for Acral Lentiginous Melanoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

33
Lymph node, Skin

Animal Models for Acral Lentiginous Melanoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.8MUC1, VIM
2MP:00053768.7CSPG4, TFRC, NRAS, PLD1
3MP:00020068.4MET, NRAS, MUC1, CDKN2A, PLD1
4MP:00053818.3TFRC, MET, NRAS, MUC1, CDKN2A
5MP:00030128.2CDKN2A, MUC1, NRAS, MET, CSPG4
6MP:00053708.1CDKN2A, MUC1, NRAS, MET, TFRC, CSPG4

Publications for Acral Lentiginous Melanoma

Sources:
51PubMed
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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
2
Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. (23362968)
2013
3
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. (22157852)
2012
4
Unique prognostic factors in acral lentiginous melanoma. (23022254)
2012
5
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. (21732773)
2011
6
Acral lentiginous melanoma. (21549241)
2011
7
Acral pigmented spitz nevus that clinically mimicked acral lentiginous malignant melanoma. (21747632)
2011
8
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
9
Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb. (20545949)
2011
10
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
11
Unilateral lichen planus pigmentosus mimicking acral lentiginous melanoma. (20677541)
2010
12
The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. (20448346)
2010
13
Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. (19380664)
2009
14
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. (18822168)
2008
15
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
16
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
17
Acral lentiginous melanoma: histopathological prognostic features of 121 cases. (17596173)
2007
18
Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. (17083858)
2006
19
Acral lentiginous melanoma: a clinicoprognostic study of 126 cases. (16911282)
2006
20
Case of the month. Pigmented acral-lentiginous melanoma (ALM). (16483079)
2006
21
Acral lentiginous melanoma: an immunohistochemical study of 20 cases. (12709000)
2003
22
Regression of an acral lentiginous melanoma with an immunotherapy using a Mycobacterium tuberculosis-extracted polysaccharide complex (Tubercin). (11895517)
2002
23
Acral-lentiginous melanoma. (10881468)
2000
24
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
25
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
26
Acral lentiginous melanoma. (20877020)
2000
27
Acral lentiginous melanoma. (9879051)
1998
28
Distinctive dermatoscopic features of acral lentiginous melanoma in situ from plantar melanocytic nevi and their histopathologic correlation. (9558302)
1998
29
A foot "ulcer" resistant to healing. Acral-lentiginous melanoma. (9204806)
1997
30
Acral lentiginous melanoma of the palm. (9136165)
1996
31
Acral lentiginous melanoma (including in situ melanoma) arising in association with naevocellular naevi. (8819127)
1996
32
A case of acral melanocytic hyperplasia: a unique pigmented lesion mimicking acral lentiginous melanoma in situ. (8935628)
1996
33
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
34
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. (1671829)
1991
35
Acral lentiginous melanoma. Pedal lesions in the black population. (3246658)
1988
36
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
37
Acral lentiginous melanoma. A report of a case and a review of the literature. (3681672)
1987
38
Improved survival rates of patients with acral lentiginous melanoma treated with hyperthermic isolation perfusion, wide excision, and regional lymphadenectomy. (3518512)
1986
39
Tinea nigra masquerading as acral lentiginous melanoma. (3700830)
1986
40
Acral lentiginous melanoma and its precursor--heterogeneity of palmo-plantar melanomas. (4047728)
1985
41
Acral lentiginous melanoma: an illustrative case report and brief review of the literature. (6498406)
1984
42
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
43
Acral lentiginous melanoma of the oral cavity. (6841121)
1983
44
Acral lentiginous melanoma of the penis. (7075635)
1982
45
The color of the skin of the palms and soles as a possible clue to the pathogenesis of acral-lentiginous melanoma. (7149195)
1982
46
Congenital acral melanocytic nevi clinically stimulating acral lentiginous melanoma. (7287955)
1981
47
Acral lentiginous melanoma. (7389397)
1980
48
Acral lentiginous melanoma. (7396539)
1980
49
Acral lentiginous melanoma. (7447295)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Genetic Variations for Acral Lentiginous Melanoma

Expression for genes affiliated with Acral Lentiginous Melanoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Acral Lentiginous Melanoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1creatinine4510.3CDKN2A
2eosin4510.1MUC1, VIM
3s 1004510.1MUC1, VIM
4fluorochrome4510.1TFRC, VIM
5reticulin4510.0VIM, MUC1
6mucicarmine4510.0MUC1, VIM
7temozolomide45 1110.8CDKN2A, VIM
8crcs459.8MET, MUC1, CDKN2A
9dmso459.7VIM, TFRC, MUC1
10k252a459.7VIM, MET
11hematoxylin459.7CDKN2A, MUC1, VIM
12b 723459.5MUC1, VIM
13cytarabine45 50 1111.4VIM, TFRC, MUC1, CDKN2A
14methotrexate45 50 1111.4VIM, MUC1, CDKN2A
15biotin45 11 2411.4CDKN2A, MUC1, TFRC, VIM
16folate459.4CDKN2A, MUC1, TFRC, VIM
17doxorubicin45 50 1111.4CDKN2A, MET, TFRC, VIM
18cisplatin45 50 60 1112.4CDKN2A, MUC1, MET, TFRC
19genistein45 29 60 2 11 2414.3VIM, TFRC, MET, CDKN2A
20chloramphenicol45 2 1111.3CDKN2A, MUC1, VIM
2112-o-tetradecanoylphorbol 13-acetate459.3VIM, MET, MUC1, PLD1
22progesterone45 60 29 11 2413.2CDKN2A, MUC1, MET, VIM
23adriamycin459.1CDKN2A, MUC1, MET, TFRC, VIM
24arginine459.1VIM, TFRC, MET, CDKN2A, KRT9
25actinomycin d459.1VIM, TFRC, MET, MUC1, CDKN2A
26paraffin459.1CDKN2A, MUC1, MET, TFRC, VIM
27testosterone45 60 11 2412.1VIM, TFRC, MET, MUC1, CDKN2A
28vegf459.0VIM, TFRC, MET, MUC1, CDKN2A
29h2o2459.0VIM, TFRC, CDKN2A, PLD1
30estrogen459.0VIM, TFRC, MET, MUC1, CDKN2A
31agar459.0VIM, MET, NRAS, MUC1, CDKN2A
32oligonucleotide458.9CDKN2A, NRAS, MET, VIM
33cholesterol45 29 11 2411.9PLD1, CDKN2A, MUC1, MET
34cycloheximide458.9VIM, TFRC, MET, CDKN2A, PLD1
35alanine458.8VIM, TFRC, MET, CDKN2A, PLD1
36lipid458.6PLD1, CDKN2A, MUC1, MET, VIM
37retinoic acid45 249.5VIM, TFRC, MET, MUC1, CDKN2A, PLD1
38cysteine458.5VIM, TFRC, MET, MUC1, CDKN2A, PLD1

GO Terms for genes affiliated with Acral Lentiginous Melanoma

Sources:
16Gene Ontology
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Biological processes related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.8KRT9, VIM
2Ras protein signal transductionGO:0072658.8PLD1, CDKN2A, NRAS

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet