ALM
MCID: ACR014
MIFTS: 45

Acral Lentiginous Melanoma (ALM) malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Acral Lentiginous Melanoma

Aliases & Descriptions for Acral Lentiginous Melanoma:

Name: Acral Lentiginous Melanoma 12 50 14
Acral Lentiginous Malignant Melanoma of Skin 50
Acral Lentiginous Melanoma, Malignant 12
Malignant Acral Lentiginous Melanoma 12
Acral Lentiginous Malignant Melanoma 69
Palmar/plantar Melanoma 50
Subungual Melanoma 50
Alm 50

Classifications:



External Ids:

Disease Ontology 12 DOID:6367

Summaries for Acral Lentiginous Melanoma

NIH Rare Diseases : 50 acral lentiginous melanoma (alm) is a type of melanoma that occurs on the palms of the hands or the soles of the feet. the condition can develop in normal-appearing skin or within an existing mole. alm begins as a flat patch of discolored skin that may enlarge slowly over time. although the cancer cells often remain contained at the skins surface (epidermis) initially, alm can become invasive and spread as the condition advances. like other flat forms of melanoma, it can be recognized by the abcde rule. although alm affects men and women of all skin colors equally, is it most commonly diagnosed in people over age 40. the underlying cause of alm is poorly understood. it is not related to sun exposure like other forms of skin cancer. initial treatment generally consists of surgery to remove the skin lesion. additional therapy (such as radiation therapy or immunotherapy) may then be recommended depending on the severity of the condition. last updated: 4/3/2017

MalaCards based summary : Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to alstrom syndrome and melanoma, and has symptoms including macule An important gene associated with Acral Lentiginous Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. The drugs Dasatinib and Sunitinib have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are Decreased substrate adherent cell growth and cellular

Disease Ontology : 12 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

Wikipedia : 71 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. Melanoma is a potentially serious... more...

Related Diseases for Acral Lentiginous Melanoma

Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Related Disease Score Top Affiliating Genes
1 alstrom syndrome 11.1
2 melanoma 11.0
3 verrucous papilloma 10.2 KIT NRAS
4 cerebral arterial disease 10.2 KIT NRAS
5 brachydactyly tibial hypoplasia 10.2 CDKN2A TERT
6 pseudomonas stutzeri infections 10.2 BRAF NRAS
7 rdh12-related leber congenital amaurosis 10.2 BRAF NRAS
8 diffuse glomerulonephritis 10.2 KIT NRAS
9 splenic manifestation of prolymphocytic leukemia 10.2 BRAF NRAS
10 gallbladder pleomorphic giant cell adenocarcinoma 10.1 CDKN2A NRAS
11 adult epithelioid sarcoma 10.1 CDKN2A NRAS
12 ossifying fibromyxoid tumor 10.1 CDKN2A NRAS
13 vulva basal cell carcinoma 10.1 CDKN2A KIT
14 fragile x-associated tremor/ataxia syndrome 10.1 CDKN2A KIT
15 stomach diverticulosis 10.1 BRAF KIT
16 uterine corpus leiomyomatosis 10.1 CDKN2A NRAS
17 vaginal yolk sac tumor 10.1 KIT NRAS
18 spondylarthropathy 10.1 BRAF CDKN2A
19 extranodal nasal nk/t cell lymphoma 10.1 CDKN2A KIT
20 plasmodium ovale malaria 10.1 CDKN2A KIT
21 retroperitoneal leiomyosarcoma 10.1 KIT NRAS
22 pacinian tumor 10.1 CDKN2A KIT
23 monkeypox 10.1 KIT PTEN
24 familial hyperaldosteronism 10.1 KIT NRAS
25 small intestinal sarcoma 10.1 KIT PTEN
26 sarcoma 10.1
27 laryngitis 10.1
28 urethral verrucous carcinoma 10.1 CDKN2A PTEN
29 ganglioneuroblastoma 10.0 MET TERT
30 charcot-marie-tooth disease type 2n 10.0 CDKN2A TERT
31 multifocal osteogenic sarcoma 10.0 CDKN2A KIT
32 vulval paget's disease 10.0 CDKN2A KIT NRAS
33 facial hemiatrophy 10.0 CDKN2A KIT NRAS
34 nelson syndrome 10.0 CDKN2A KIT NRAS
35 anal neuroendocrine tumor 10.0 CDKN2A MET
36 alpha chain disease 10.0 CDKN2A KIT NRAS
37 leukemia, acute myeloid 10.0 KIT NRAS TERT
38 house allergic alveolitis 10.0 CDKN2A MET
39 myxedema 10.0 CDKN2A PTEN
40 nodular cutaneous amyloidosis 10.0 CDKN2A TERT
41 lattice corneal dystrophy 10.0 BRAF CDKN2A NRAS
42 parotid gland adenoid cystic carcinoma 10.0 KIT NRAS PTEN
43 lice infestation 9.9 KIT MET
44 hepatic flexure cancer 9.9 CDKN2A PTEN TERT
45 nevoid hypermelanosis, linear and whorled 9.9 CDKN2A PTEN TERT
46 muscular dystrophy-dystroglycanopathy , type a, 10 9.9 BRAF NRAS PTEN
47 interstitial lung disease 9.9 CDKN2A PTEN
48 psoriatic arthritis 9.9
49 multiple myeloma 9.9
50 arthritis 9.9

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to Acral Lentiginous Melanoma

Symptoms & Phenotypes for Acral Lentiginous Melanoma

UMLS symptoms related to Acral Lentiginous Melanoma:


macule

GenomeRNAi Phenotypes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.23 KIT MET
2 Decreased substrate adherent cell growth GR00193-A-2 9.23 KIT
3 Decreased substrate adherent cell growth GR00193-A-3 9.23 MET BRAF
4 Decreased substrate adherent cell growth GR00193-A-4 9.23 BRAF KIT MET

MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

44 (show all 23)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 TERT BRAF CDKN2A KIT MET NRAS
2 digestive/alimentary MP:0005381 10.14 BRAF CDKN2A KIT MET NRAS PTEN
3 endocrine/exocrine gland MP:0005379 10.12 BRAF CDKN2A KIT MET NRAS PTEN
4 growth/size/body region MP:0005378 10.11 BRAF CDKN2A KIT MET NRAS PTEN
5 behavior/neurological MP:0005386 10.09 BRAF CDKN2A KIT MET NRAS PTEN
6 homeostasis/metabolism MP:0005376 10.09 BRAF CDKN2A KIT MET NRAS PTEN
7 cardiovascular system MP:0005385 10.08 BRAF CDKN2A KIT MET NRAS PTEN
8 immune system MP:0005387 10.08 BRAF CDKN2A KIT MET NRAS PTEN
9 embryo MP:0005380 10.06 BRAF CDKN2A KIT MET NRAS PTEN
10 hematopoietic system MP:0005397 10.03 BRAF CDKN2A KIT NRAS PTEN TERT
11 mortality/aging MP:0010768 10.02 BRAF CDKN2A KIT MET NRAS PTEN
12 neoplasm MP:0002006 9.98 BRAF CDKN2A KIT MET NRAS PTEN
13 liver/biliary system MP:0005370 9.97 BRAF CDKN2A KIT MET NRAS PTEN
14 integument MP:0010771 9.92 PTEN BRAF CDKN2A KIT NRAS
15 nervous system MP:0003631 9.88 BRAF CDKN2A KIT MET PTEN TERT
16 muscle MP:0005369 9.85 CDKN2A KIT MET PTEN BRAF
17 normal MP:0002873 9.85 BRAF KIT MET NRAS PTEN TERT
18 limbs/digits/tail MP:0005371 9.81 KIT MET NRAS PTEN
19 pigmentation MP:0001186 9.72 BRAF CDKN2A KIT NRAS PTEN
20 reproductive system MP:0005389 9.65 BRAF CDKN2A KIT PTEN TERT
21 respiratory system MP:0005388 9.63 MET PTEN TERT BRAF CDKN2A KIT
22 skeleton MP:0005390 9.35 BRAF CDKN2A KIT PTEN TERT
23 vision/eye MP:0005391 9.1 BRAF CDKN2A KIT MET NRAS PTEN

Drugs & Therapeutics for Acral Lentiginous Melanoma

Drugs for Acral Lentiginous Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
2
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
3
Dabrafenib Approved Phase 2 44462760 44516822
4
Pembrolizumab Approved Phase 2 1374853-91-4
5
Trametinib Approved Phase 2 871700-17-3 11707110
6
nivolumab Approved Phase 2 946414-94-4
7
Cediranib Investigational Phase 2 288383-20-0 9933475
8
Maleic acid Experimental Phase 2 110-16-7 444266
9 Protein Kinase Inhibitors Phase 2
10 Imatinib Mesylate Phase 2 123596
11 Angiogenesis Inhibitors Phase 2
12 Angiogenesis Modulating Agents Phase 2
13 Immunoglobulins Phase 2
14 Antibodies, Monoclonal Phase 2
15 Antibodies Phase 2
16 tyrosine Nutraceutical Phase 2
17
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
18 Ganciclovir triphosphate Phase 1
19 Nucleic Acid Synthesis Inhibitors Phase 1
20 Anti-Infective Agents Phase 1
21 Antiviral Agents Phase 1

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma, Acral Melanoma, or Vulvovaginal Melanoma That Cannot Be Removed By Surgery Unknown status NCT00700882 Phase 2
2 SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma Completed NCT00577382 Phase 2
3 A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread Completed NCT01395121 Phase 2
4 Imatinib in Patients With Mucosal or Acral/Lentiginous Melanoma Completed NCT00424515 Phase 2
5 Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00470470 Phase 2
6 Nilotinib in TKI Resistant or Intolerant Patients With Metastatic Mucosal, Acral, or Chronically Sun Damaged Melanoma Completed NCT00788775 Phase 2
7 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2
8 Pembrolizumab in Advanced/Metastatic Acral Lentiginous Melanoma Recruiting NCT02875132 Phase 2
9 A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Recruiting NCT02978443 Phase 2
10 Study to Investigate the Objective Response Rate of Dabrafenib in Combination With Trametinib in Subjects With BRAF V600 Mutation-Positive Melanoma Recruiting NCT02083354 Phase 2
11 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2
12 Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma Terminated NCT01092728 Phase 2
13 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2
14 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1
15 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

Anatomical Context for Acral Lentiginous Melanoma

MalaCards organs/tissues related to Acral Lentiginous Melanoma:

39
Skin, Lymph Node, Brain

Publications for Acral Lentiginous Melanoma

Articles related to Acral Lentiginous Melanoma:

(show top 50) (show all 121)
id Title Authors Year
1
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma. ( 26796627 )
2016
2
Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. ( 27518480 )
2016
3
Histopathological diagnosis of acral lentiginous melanoma in early stages. ( 27601330 )
2016
4
Acral Lentiginous Melanoma. ( 26601870 )
2016
5
Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas. ( 26709572 )
2016
6
Acral lentiginous melanoma with multiple brain metastases in an Indian male. ( 27559525 )
2016
7
Erratum to A<Laryngeal metastases of acral lentiginous melanoma: Narrow band imagingA>. ( 27393792 )
2016
8
Amelanotic acral lentiginous melanoma mimicking diabetic ulcer: a challenge to diagnose and treat. ( 26679765 )
2016
9
Rare cause of non-healing foot wound - acral lentiginous melanoma. Case Report. ( 26994380 )
2016
10
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man. ( 26838298 )
2016
11
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma. ( 26088594 )
2015
12
IMAGES IN CLINICAL MEDICINE. Acral Lentiginous Melanoma. ( 26535515 )
2015
13
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. ( 25773399 )
2015
14
Reconstruction of large wounds using a combination of negative pressure wound therapy and punch grafting after excision of acral lentiginous melanoma on the foot. ( 26173565 )
2015
15
Screening for Acral Lentiginous Melanoma in Dark-Skinned Individuals. ( 26083954 )
2015
16
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. ( 26588333 )
2015
17
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? ( 25455840 )
2015
18
Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer a cautionary case. ( 25815661 )
2015
19
Reflectance confocal microscopy features of acral lentiginous melanoma: a comparative study with acral nevi. ( 26428577 )
2015
20
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. ( 25252087 )
2014
21
Two Spanish cases of Atypical Melanosis of the Foot, an early stage of Acral Lentiginous Melanoma in situ. ( 25323966 )
2014
22
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. ( 25396085 )
2014
23
Acral Lentiginous Melanoma - Misdiagnosis, referral delay and 5 years specific survival according to site. ( 25027337 )
2014
24
Indolent Subtype Acral Lentiginous Melanoma With Long Radial Growth Phase: A Dermatopathological Pitfall. ( 25072690 )
2014
25
TERT gene amplification is associated with poor outcome in acral lentiginous melanoma. ( 25219713 )
2014
26
Laryngeal metastases of acral lentiginous melanoma: Narrow band imaging. ( 25488159 )
2014
27
Recurrent acral lentiginous melanoma in situ suggesting the field cell theory. ( 25473243 )
2014
28
Prognostic and Clinicopathologic Associations of BRAF Mutation in Primary Acral Lentiginous Melanoma in Korean Patients: A Preliminary Study. ( 24882974 )
2014
29
Acral lentiginous melanoma: indolent subtype with long radial growth phase. ( 24556899 )
2014
30
TERT promoter mutation is uncommon in acral lentiginous melanoma. ( 24588324 )
2014
31
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? ( 24249911 )
2013
32
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. ( 22931051 )
2013
33
Clinical presentation of acral lentiginous melanoma: a descriptive study. ( 22959666 )
2013
34
Genetic alterations in RAS-regulated pathway in acral lentiginous melanoma. ( 23362874 )
2013
35
Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. ( 23362968 )
2013
36
Conservative surgical treatment of a thin acral lentiginous melanoma of the thumb with no recurrences: a case report. ( 23742286 )
2013
37
KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma. ( 23993026 )
2013
38
Traumatic Hematoma in a Palmoplantar wart Mimicking Acral Lentiginous Melanoma. ( 23060711 )
2012
39
Consumption of the epidermis in acral lentiginous melanoma. ( 22574622 )
2012
40
Unique prognostic factors in acral lentiginous melanoma. ( 23022254 )
2012
41
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. ( 22157852 )
2012
42
Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb. ( 20545949 )
2011
43
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. ( 21732773 )
2011
44
Acral Lentiginous Melanoma Developing during Long-standing Atypical Melanosis: Usefulness of Dermoscopy for Detection of Early Acral Melanoma. ( 21909219 )
2011
45
The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma). ( 21167406 )
2011
46
Acral lentiginous melanoma. ( 21549241 )
2011
47
Letter: Acral-lentiginous melanoma: Report of 15 cases. ( 21272506 )
2011
48
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. ( 21615605 )
2011
49
Acral lentiginous melanoma: a case control study and guidelines update. ( 21541184 )
2011
50
Unilateral lichen planus pigmentosus mimicking acral lentiginous melanoma. ( 20677541 )
2010

Variations for Acral Lentiginous Melanoma

Cosmic variations for Acral Lentiginous Melanoma:

9 (show top 50) (show all 60)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM1166809 PTEN skin,acral,malignant melanoma,acral lentiginous c.333G>A p.W111* 22
2 COSM562 NRAS skin,acral,malignant melanoma,acral lentiginous c.34G>T p.G12C 22
3 COSM1290 KIT skin,acral,malignant melanoma,acral lentiginous c.1727T>C p.L576P 22
4 COSM1257 KIT skin,acral,malignant melanoma,acral lentiginous c.1679T>A p.V560D 22
5 COSM1255 KIT skin,acral,malignant melanoma,acral lentiginous c.1676T>C p.V559A 22
6 COSM235682 KIT skin,acral,malignant melanoma,acral lentiginous c.1965T>G p.N655K 22
7 COSM18682 KIT skin,acral,malignant melanoma,acral lentiginous c.2468A>G p.Y823C 22
8 COSM1430154 KIT skin,acral,malignant melanoma,acral lentiginous c.1715A>G p.D572G 22
9 COSM460 BRAF skin,acral,malignant melanoma,acral lentiginous c.1406G>C p.G469A 22
10 COSM565 NRAS skin,subungual,malignant melanoma,acral lentiginous c.35G>C p.G12A 16
11 COSM29529 RB1 skin,NS,malignant melanoma,acral lentiginous c.1411C>T p.Q471* 14
12 COSM583 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>T p.Q61L 14
13 COSM253327 NRAS skin,acral,malignant melanoma,NS c.176C>A p.A59D 14
14 COSM580 NRAS skin,NS,malignant melanoma,acral lentiginous c.181C>A p.Q61K 14
15 COSM584 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>G p.Q61R 14
16 COSM566 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>T p.G12V 14
17 COSM564 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 14
18 COSM577 NRAS skin,NS,malignant melanoma,acral lentiginous c.52G>A p.A18T 14
19 COSM573 NRAS skin,NS,malignant melanoma,acral lentiginous c.38G>A p.G13D 14
20 COSM3724522 NRAS skin,NS,malignant melanoma,acral lentiginous c.184G>C p.E62Q 14
21 COSM563 NRAS skin,NS,malignant melanoma,acral lentiginous c.34G>A p.G12S 14
22 COSM569 NRAS skin,acral,malignant melanoma,NS c.37G>C p.G13R 14
23 COSM521 KRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 14
24 COSM1651644 KIT skin,NS,malignant melanoma,acral lentiginous c.2449A>C p.I817L 14
25 COSM1273 KIT skin,acral,malignant melanoma,NS c.1696A>G p.N566D 14
26 COSM1304 KIT skin,NS,malignant melanoma,acral lentiginous c.1924A>G p.K642E 14
27 COSM33966 KIT skin,acral,malignant melanoma,NS c.1726C>T p.L576F 14
28 COSM133756 KIT skin,acral,malignant melanoma,NS c.2542T>C p.F848L 14
29 COSM133763 KIT skin,acral,malignant melanoma,NS c.1657T>A p.Y553N 14
30 COSM144512 KIT skin,NS,malignant melanoma,acral lentiginous c.1904A>G p.E635G 14
31 COSM133765 KIT skin,acral,malignant melanoma,NS c.1898A>G p.E633G 14
32 COSM133767 KIT skin,acral,malignant melanoma,NS c.2558G>A p.W853* 14
33 COSM144520 KIT skin,acral,malignant melanoma,NS c.1694G>A p.G565E 14
34 COSM250098 KIT skin,acral,malignant melanoma,NS c.1656G>A p.M552I 14
35 COSM33972 KIT skin,NS,malignant melanoma,acral lentiginous c.1915T>C p.S639P 14
36 COSM133757 KIT skin,acral,malignant melanoma,NS c.2486C>T p.A829V 14
37 COSM1578125 KIT skin,NS,malignant melanoma,acral lentiginous c.2591C>T p.S864F 14
38 COSM133769 KIT skin,acral,malignant melanoma,NS c.2576T>C p.L859P 14
39 COSM133762 KIT skin,acral,malignant melanoma,NS c.2450T>C p.I817T 14
40 COSM36305 KIT skin,acral,malignant melanoma,NS c.1745G>A p.W582* 14
41 COSM1321 KIT skin,acral,malignant melanoma,NS c.2466T>A p.N822K 14
42 COSM1651643 KIT skin,NS,malignant melanoma,acral lentiginous c.1420G>A p.V474I 14
43 COSM1219 KIT skin,acral,malignant melanoma,NS c.1669T>C p.W557R 14
44 COSM133755 KIT skin,acral,malignant melanoma,NS c.1469A>G p.E490G 14
45 COSM29015 KIT skin,acral,malignant melanoma,NS c.1673A>G p.K558R 14
46 COSM133780 KIT skin,acral,malignant melanoma,NS c.2531G>A p.C844Y 14
47 COSM133774 KIT skin,acral,malignant melanoma,NS c.1687A>G p.I563V 14
48 COSM133760 KIT skin,acral,malignant melanoma,NS c.1942G>A p.G648S 14
49 COSM107839 GRIN2A skin,NS,malignant melanoma,acral lentiginous c.2786C>T p.S929F 14
50 COSM107986 GRIN2A skin,NS,malignant melanoma,acral lentiginous c.1774A>G p.K592E 14

Expression for Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for Acral Lentiginous Melanoma

Pathways related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 32)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 BRAF CDKN2A KIT MET NRAS PTEN
2
Show member pathways
13.39 BRAF CDKN2A KIT MET NRAS PTEN
3
Show member pathways
12.69 BRAF KIT MET NRAS PTEN
4
Show member pathways
12.68 BRAF MET NRAS PTEN
5
Show member pathways
12.67 BRAF KIT MET NRAS
6
Show member pathways
12.67 BRAF MET NRAS PTEN
7
Show member pathways
12.56 BRAF MET NRAS PTEN
8
Show member pathways
12.49 BRAF KIT MET NRAS
9
Show member pathways
12.49 BRAF CDKN2A KIT MET NRAS PTEN
10
Show member pathways
12.48 KIT MET NRAS PTEN
11 12.33 KIT MET NRAS PTEN
12 12.24 CDKN2A NRAS TERT
13 12.23 CDKN2A MET NRAS PTEN
14
Show member pathways
12.2 BRAF MET NRAS PTEN
15
Show member pathways
12.19 BRAF NRAS PTEN
16 12.1 BRAF MET NRAS
17
Show member pathways
11.98 BRAF MET PTEN
18
Show member pathways
11.98 BRAF KIT NRAS PTEN
19
Show member pathways
11.91 BRAF CDKN2A NRAS
20
Show member pathways
11.89 BRAF NRAS PTEN
21 11.79 CDKN2A NRAS PTEN
22 11.73 BRAF CDKN2A PTEN
23 11.7 BRAF CDKN2A KIT MET NRAS PTEN
24
Show member pathways
11.61 BRAF KIT NRAS
25 11.6 BRAF CDKN2A NRAS PTEN
26 11.52 BRAF CDKN2A NRAS
27 11.43 BRAF NRAS
28 11.18 BRAF NRAS
29 11.11 MET NRAS
30 11.11 NRAS PTEN
31 11.09 BRAF NRAS
32 11.07 KIT MET NRAS PTEN

GO Terms for Acral Lentiginous Melanoma

Cellular components related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 KIT PTEN

Biological processes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.73 BRAF CDKN2A KIT MET
2 positive regulation of gene expression GO:0010628 9.7 BRAF KIT PTEN
3 visual learning GO:0008542 9.51 BRAF KIT
4 phosphatidylinositol-mediated signaling GO:0048015 9.5 KIT MET PTEN
5 long-term synaptic potentiation GO:0060291 9.49 BRAF PTEN
6 cellular response to nerve growth factor stimulus GO:1990090 9.48 BRAF PTEN
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.46 BRAF TERT
8 replicative senescence GO:0090399 9.4 CDKN2A TERT
9 somatic stem cell division GO:0048103 9.37 CDKN2A KIT
10 regulation of axon regeneration GO:0048679 9.26 BRAF PTEN
11 myeloid progenitor cell differentiation GO:0002318 9.16 BRAF KIT
12 regulation of protein stability GO:0031647 9.13 CDKN2A PTEN TERT
13 MAPK cascade GO:0000165 8.92 BRAF KIT MET NRAS

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.26 BRAF CDKN2A KIT MET
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KIT MET
3 nucleotide binding GO:0000166 8.92 BRAF KIT MET NRAS

Sources for Acral Lentiginous Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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34 ICD10 via Orphanet
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70 UMLS via Orphanet
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