ALM
MCID: ACR014
MIFTS: 49

Acral Lentiginous Melanoma (ALM) malady

Rare diseases, Cancer diseases, Skin diseases categories
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Summaries for Acral Lentiginous Melanoma

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Disease Ontology:8 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

MalaCards based summary: Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and sarcoma. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Renal cell carcinoma and Cell adhesion Cell matrix glycoconjugates. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

Aliases & Classifications for Acral Lentiginous Melanoma

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Acral Lentiginous Melanoma, Aliases & Descriptions:

Name: Acral Lentiginous Melanoma 8 42 10
Acral Lentiginous Malignant Melanoma of Skin 42 62
Acral Lentiginous Melanoma, Malignant 8
Acral Lentiginous Malignant Melanoma 62
 
Malignant Acral Lentiginous Melanoma 8
Palmar/plantar Melanoma 42
Subungual Melanoma 42
Alm 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:6367

Related Diseases for Acral Lentiginous Melanoma

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Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.4CSPG4, CDKN2A, NRAS, MET, KRT9, ANKRD36B
2sarcoma30.2MUC1, MET, NRAS, VIM
3eccrine porocarcinoma10.5MUC1
4hidradenoma10.4MUC1
5syringoma10.4MUC1
6cystadenocarcinoma10.4MUC1
7adenomatoid tumor10.4VIM
8paraganglioma10.4VIM
9arthritis10.3
10multiple myeloma10.3
11lichen planus10.3
12psoriatic arthritis10.3
13tinea pedis10.3
14tinea nigra10.3
15clear cell sarcoma10.3
16basal cell carcinoma10.3
17myeloma10.3
18tuberculosis10.3
19lentigo maligna melanoma10.3
20lichen planus pigmentosus10.3
21chordoma10.2VIM, MUC1
22clear cell ependymoma10.2VIM, MUC1
23mesenchymal chondrosarcoma10.2VIM, MUC1
24spindle cell carcinoma10.2MUC1, VIM
25spindle cell sarcoma10.2MUC1, VIM
26epithelioid sarcoma10.2MUC1, VIM
27sertoli cell tumor10.2MUC1, VIM
28secretory meningioma10.2MUC1, VIM
29dermatofibrosarcoma protuberans10.2MUC1, VIM
30perineurioma10.2VIM, MUC1
31rhabdoid tumor10.2VIM, MUC1
32sex cord-gonadal stromal tumor10.2VIM, MUC1
33hemangiopericytoma10.2VIM, MUC1
34malignant mixed mullerian tumor10.2VIM, MUC1
35alstrom syndrome10.2
36lupus nephritis10.2
37nephritis10.2
38angiosarcoma10.2MUC1, VIM
39abrikosov's tumor10.2MUC1, VIM
40giant cell tumor10.2MUC1, VIM
41pleomorphic adenoma10.2VIM, MUC1
42malignant fibroxanthoma10.2MUC1, VIM
43pyogenic granuloma10.1
44salivary gland adenoid cystic carcinoma10.1VIM, MUC1
45malignant pleural mesothelioma10.1MUC1, MET
46ependymoma10.1VIM, MUC1
47oxyphilic adenoma10.1MUC1, VIM
48proliferative vitreoretinopathy10.1TFRC, MET
49leiomyosarcoma10.1MUC1, VIM
50neuronitis10.0

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Symptoms for Acral Lentiginous Melanoma

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Drugs & Therapeutics for Acral Lentiginous Melanoma

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Drug clinical trials:

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Genetic Tests for Acral Lentiginous Melanoma

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Anatomical Context for Acral Lentiginous Melanoma

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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

32
Skin, Lymph node

Animal Models for Acral Lentiginous Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MUC1, MET, NRAS, KRT9, CDKN2A
2MP:00053818.6CDKN2A, NRAS, MET, MUC1, TFRC
3MP:00030128.5MUC1, MET, CSPG4, NRAS, CDKN2A
4MP:00053918.4VIM, MUC1, MET, NRAS, CDKN2A
5MP:00053808.4CDKN2A, NRAS, MET, VIM, TFRC
6MP:00107718.4TFRC, MUC1, NRAS, KRT9, CDKN2A
7MP:00053708.3CDKN2A, NRAS, CSPG4, MET, MUC1, TFRC
8MP:00053847.8TFRC, VIM, MET, CSPG4, NRAS, KRT9
9MP:00053877.8TFRC, VIM, MET, CSPG4, NRAS, CDKN2A
10MP:00053787.7TFRC, VIM, MET, CSPG4, NRAS, KRT9
11MP:00053767.7TFRC, VIM, MUC1, MET, CSPG4, NRAS

Publications for Acral Lentiginous Melanoma

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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
TERT promoter mutation is uncommon in acral lentiginous melanoma. (24588324)
2014
2
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. (25396085)
2014
3
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. (25252087)
2014
4
Two Spanish cases of Atypical Melanosis of the Foot, an early stage of Acral Lentiginous Melanoma in situ. (25323966)
2014
5
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
6
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? (24249911)
2013
7
KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma. (23993026)
2013
8
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. (22157852)
2012
9
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. (21732773)
2011
10
The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma). (21167406)
2011
11
Acral lentiginous melanoma. (21549241)
2011
12
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
13
Acral lentiginous melanoma: a case control study and guidelines update. (21541184)
2011
14
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
15
Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma. (20466190)
2010
16
Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. (18758972)
2009
17
Progression from Acral Lentiginous Melanoma in situ to Invasive Acral Lentiginous Melanoma. (20523783)
2009
18
Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. (19380664)
2009
19
Expression of p16 protein in acral lentiginous melanoma. (20415670)
2009
20
Acral lentiginous melanoma: conventional histology vs. three-dimensional histology. (19067697)
2009
21
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. (18822168)
2008
22
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
23
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
24
Acral lentiginous melanoma: histopathological prognostic features of 121 cases. (17596173)
2007
25
Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. (17083858)
2006
26
Acral lentiginous melanoma in situ: a study of nine cases. (15249858)
2004
27
Acral lentiginous melanoma: an immunohistochemical study of 20 cases. (12709000)
2003
28
Acral lentiginous melanoma mimicking benign disease: the Emory experience. (12582386)
2003
29
Acral-lentiginous melanoma. (10881468)
2000
30
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
31
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
32
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. (10434891)
1999
33
Acral lentiginous melanoma. (9879051)
1998
34
Plantar flap reconstruction for acral lentiginous melanoma. (9367024)
1997
35
Acral lentiginous melanoma of the palm. (9136165)
1996
36
Acral lentiginous melanoma. (8328633)
1993
37
Acral lentiginous melanoma associated with Down's syndrome. (8482754)
1993
38
Acral lentiginous melanoma: case studies from Kauai. (1428854)
1992
39
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
40
The current management and prognosis of acral lentiginous melanoma. (1642394)
1992
41
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
42
Pigmented freckles on the sole of acral lentiginous melanoma in situ. (3908530)
1985
43
Acral lentiginous melanoma: an illustrative case report and brief review of the literature. (6498406)
1984
44
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
45
Acral lentiginous melanoma and lentigo maligna occurring in Werner's syndrome. (6627991)
1983
46
Acral lentiginous melanoma in situ. (7122752)
1982
47
Acral lentiginous melanoma of the penis. (7075635)
1982
48
Dermatology-epitomes of progress: acral lentiginous melanoma. (18748764)
1981
49
Acral lentiginous melanoma. (7389397)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Variations for Acral Lentiginous Melanoma

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Expression for genes affiliated with Acral Lentiginous Melanoma

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Expression patterns in normal tissues for genes affiliated with Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

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Pathways related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NRAS, MET
29.6CSPG4, MUC1
39.3CDKN2A, NRAS, MET
4
Show member pathways
Signaling Pathways in Glioblastoma37
9.3MET, NRAS, CDKN2A
58.8CDKN2A, NRAS, MET, VIM
6
Show member pathways
8.4VIM, MUC1, MET, NRAS, CDKN2A

Compounds for genes affiliated with Acral Lentiginous Melanoma

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Compounds related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1eosin4410.0MUC1, VIM
2s 1004410.0MUC1, VIM
3reticulin4410.0MUC1, VIM
4mucicarmine4410.0MUC1, VIM
5fluorochrome449.9VIM, TFRC
6b 723449.8VIM, MUC1
7k252a449.8VIM, MET
8temozolomide44 1110.8VIM, CDKN2A
9crcs449.7MUC1, MET, CDKN2A
10leupeptin449.7VIM, TFRC
11doxycycline44 1110.6CDKN2A, TFRC
12dmso449.6TFRC, VIM, MUC1
13hematoxylin449.6CDKN2A, MUC1, VIM
14roscovitine449.5CDKN2A, VIM
15matrigel449.5MET, MUC1, VIM
16methotrexate50 44 1111.5CDKN2A, MUC1, VIM
17chloramphenicol44 2 50 1112.5VIM, MUC1, CDKN2A
1812-o-tetradecanoylphorbol 13-acetate449.5MET, MUC1, VIM
19vitamin d449.4MET, VIM, TFRC
20rapamycin449.3MET, VIM, TFRC
21paclitaxel44 50 1111.3TFRC, VIM, CDKN2A
22wortmannin449.3TFRC, VIM, MET
23cisplatin44 50 61 1112.3TFRC, MUC1, MET, CDKN2A
24glycogen44 2410.3VIM, MUC1, MET
25biotin44 24 1111.2CDKN2A, MUC1, VIM, TFRC
26cytarabine44 50 1111.2TFRC, VIM, MUC1, CDKN2A
27folate449.2CDKN2A, MUC1, VIM, TFRC
28butyrate449.2TFRC, VIM, MUC1, CDKN2A
29glutamine449.2TFRC, VIM, KRT9
30creatinine449.2CDKN2A, MUC1, VIM, TFRC
31doxorubicin44 50 1111.1TFRC, VIM, MET, CDKN2A
32genistein44 28 61 2 24 1114.1CDKN2A, MET, VIM, TFRC
33progesterone44 28 61 24 1113.1VIM, MUC1, MET, CDKN2A
34dexamethasone44 50 28 1112.1TFRC, VIM, MUC1, CDKN2A
35oligonucleotide449.1CDKN2A, NRAS, MET, VIM
36cycloheximide449.1TFRC, VIM, MET, CDKN2A
37alanine449.0TFRC, VIM, MET, CDKN2A
38agar448.9VIM, MUC1, MET, NRAS, CDKN2A
39arginine448.8TFRC, VIM, MET, KRT9, CDKN2A
40iron44 249.8CDKN2A, VIM, TFRC
41adriamycin448.8CDKN2A, MET, MUC1, VIM, TFRC
42actinomycin d448.8TFRC, VIM, MUC1, MET, CDKN2A
43paraffin448.8TFRC, VIM, MUC1, MET, CDKN2A
44testosterone44 61 24 1111.8CDKN2A, MET, MUC1, VIM, TFRC
45vegf448.8CDKN2A, MET, MUC1, VIM, TFRC
46estrogen448.8TFRC, VIM, MUC1, MET, CDKN2A
47retinoic acid44 249.8TFRC, VIM, MUC1, MET, CDKN2A
48cysteine448.8TFRC, VIM, MUC1, MET, CDKN2A
49serine448.7TFRC, VIM, MUC1, MET, CDKN2A

GO Terms for genes affiliated with Acral Lentiginous Melanoma

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Cellular components related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.2CSPG4, MUC1, TFRC
2integral component of plasma membraneGO:0058878.5TFRC, MUC1, MET, CSPG4
3extracellular vesicular exosomeGO:0700628.5KRT9, NRAS, MUC1, VIM, TFRC

Biological processes related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.7KRT9, VIM

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.7CDKN2A, MUC1
2double-stranded RNA bindingGO:0037259.3VIM, TFRC

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet