MCID: ACR014
MIFTS: 47

Acral Lentiginous Melanoma malady

Rare diseases, Skin diseases categories

Summaries for Acral Lentiginous Melanoma

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Disease Ontology:10 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

MalaCards based summary: Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and sarcoma. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Renal cell carcinoma and Cell adhesion Cell matrix glycoconjugates. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

Aliases & Classifications for Acral Lentiginous Melanoma

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Acral Lentiginous Melanoma, Aliases & Descriptions:

Name: Acral Lentiginous Melanoma 10 43 12
Acral Lentiginous Malignant Melanoma of Skin 43 62
Acral Lentiginous Melanoma, Malignant 10
Malignant Acral Lentiginous Melanoma 10
 
Acral Lentiginous Malignant Melanoma 62
Palmar/plantar Melanoma 43
Subungual Melanoma 43
Alm 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology10 DOID:6367

Related Diseases for Acral Lentiginous Melanoma

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Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.8CSPG4, CDKN2A, NRAS, MET, KRT9, ANKRD36B
2sarcoma30.4MUC1, MET, NRAS, VIM
3psoriatic arthritis10.3
4multiple myeloma10.3
5arthritis10.3
6tinea nigra10.3
7lichen planus10.3
8clear cell sarcoma10.3
9tinea pedis10.3
10basal cell carcinoma10.3
11laryngitis10.3
12myeloma10.3
13tuberculosis10.3
14lentigo maligna melanoma10.3
15lichen planus pigmentosus10.3
16alstrom syndrome10.2
17lupus nephritis10.2
18nephritis10.2
19pyogenic granuloma10.1
20eccrine porocarcinoma10.1MUC1
21hidradenoma10.1MUC1
22neuronitis10.1
23syringoma10.1MUC1
24cystadenocarcinoma10.1MUC1
25adenomatoid tumor10.0VIM
26glomus tumor10.0VIM
27renal cell carcinoma10.0MET
28chordoma10.0VIM, MUC1
29clear cell ependymoma10.0VIM, MUC1
30mesenchymal chondrosarcoma10.0VIM, MUC1
31spindle cell carcinoma10.0MUC1, VIM
32spindle cell sarcoma10.0MUC1, VIM
33epithelioid sarcoma10.0MUC1, VIM
34sertoli cell tumor10.0MUC1, VIM
35secretory meningioma10.0MUC1, VIM
36dermatofibrosarcoma protuberans10.0MUC1, VIM
37perineurioma10.0VIM, MUC1
38rhabdoid tumor10.0VIM, MUC1
39sex cord-gonadal stromal tumor10.0VIM, MUC1
40hemangiopericytoma10.0VIM, MUC1
41malignant mixed mullerian tumor10.0VIM, MUC1
42angiosarcoma10.0MUC1, VIM
43abrikosov's tumor10.0MUC1, VIM
44giant cell tumor10.0MUC1, VIM
45pleomorphic adenoma10.0VIM, MUC1
46malignant fibroxanthoma10.0MUC1, VIM
47salivary gland adenoid cystic carcinoma10.0VIM, MUC1
48malignant pleural mesothelioma10.0MUC1, MET
49ependymoma10.0VIM, MUC1
50oxyphilic adenoma10.0MUC1, VIM

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Symptoms for Acral Lentiginous Melanoma

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Drugs & Therapeutics for Acral Lentiginous Melanoma

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Drug clinical trials:

Search ClinicalTrials for Acral Lentiginous Melanoma

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

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Anatomical Context for Acral Lentiginous Melanoma

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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

33
Skin, Lymph node

Animal Models for Acral Lentiginous Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MUC1, MET, NRAS, KRT9, CDKN2A
2MP:00053818.6CDKN2A, NRAS, MET, MUC1, TFRC
3MP:00030128.5MUC1, MET, CSPG4, NRAS, CDKN2A
4MP:00053918.4VIM, MUC1, MET, NRAS, CDKN2A
5MP:00053808.4CDKN2A, NRAS, MET, VIM, TFRC
6MP:00107718.4TFRC, MUC1, NRAS, KRT9, CDKN2A
7MP:00053708.3CDKN2A, NRAS, CSPG4, MET, MUC1, TFRC
8MP:00053847.8TFRC, VIM, MET, CSPG4, NRAS, KRT9
9MP:00053877.8TFRC, VIM, MET, CSPG4, NRAS, CDKN2A
10MP:00053787.7TFRC, VIM, MET, CSPG4, NRAS, KRT9
11MP:00053767.7TFRC, VIM, MUC1, MET, CSPG4, NRAS

Publications for Acral Lentiginous Melanoma

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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? (25455840)
2015
2
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. (25773399)
2015
3
TERT promoter mutation is uncommon in acral lentiginous melanoma. (24588324)
2014
4
Recurrent acral lentiginous melanoma in situ suggesting the field cell theory. (25473243)
2014
5
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. (25396085)
2014
6
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
7
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? (24249911)
2013
8
Popliteal sentinel lymph node biopsy is important in malignant melanoma of the distal lower extremities: a case report of acral lentiginous melanoma with simultaneous inguinal and popliteal lymph node micrometastases. (22157852)
2012
9
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. (21732773)
2011
10
The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma). (21167406)
2011
11
Acral lentiginous melanoma. (21549241)
2011
12
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
13
Acral lentiginous melanoma: a case control study and guidelines update. (21541184)
2011
14
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
15
Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma. (20466190)
2010
16
Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. (18758972)
2009
17
Progression from Acral Lentiginous Melanoma in situ to Invasive Acral Lentiginous Melanoma. (20523783)
2009
18
Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. (19380664)
2009
19
Expression of p16 protein in acral lentiginous melanoma. (20415670)
2009
20
Acral lentiginous melanoma: conventional histology vs. three-dimensional histology. (19067697)
2009
21
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. (18822168)
2008
22
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
23
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
24
Acral lentiginous melanoma: histopathological prognostic features of 121 cases. (17596173)
2007
25
Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. (17083858)
2006
26
Acral lentiginous melanoma in situ: a study of nine cases. (15249858)
2004
27
Acral lentiginous melanoma: an immunohistochemical study of 20 cases. (12709000)
2003
28
Acral lentiginous melanoma mimicking benign disease: the Emory experience. (12582386)
2003
29
Acral-lentiginous melanoma. (10881468)
2000
30
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
31
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
32
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. (10434891)
1999
33
Acral lentiginous melanoma. (9879051)
1998
34
Plantar flap reconstruction for acral lentiginous melanoma. (9367024)
1997
35
Acral lentiginous melanoma of the palm. (9136165)
1996
36
Acral lentiginous melanoma. (8328633)
1993
37
Acral lentiginous melanoma associated with Down's syndrome. (8482754)
1993
38
Acral lentiginous melanoma: case studies from Kauai. (1428854)
1992
39
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
40
The current management and prognosis of acral lentiginous melanoma. (1642394)
1992
41
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
42
Pigmented freckles on the sole of acral lentiginous melanoma in situ. (3908530)
1985
43
Acral lentiginous melanoma: an illustrative case report and brief review of the literature. (6498406)
1984
44
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
45
Acral lentiginous melanoma and lentigo maligna occurring in Werner's syndrome. (6627991)
1983
46
Acral lentiginous melanoma in situ. (7122752)
1982
47
Acral lentiginous melanoma of the penis. (7075635)
1982
48
Dermatology-epitomes of progress: acral lentiginous melanoma. (18748764)
1981
49
Acral lentiginous melanoma. (7389397)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Variations for Acral Lentiginous Melanoma

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Expression for genes affiliated with Acral Lentiginous Melanoma

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Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

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Pathways related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NRAS, MET
29.6CSPG4, MUC1
39.3CDKN2A, NRAS, MET
4
Show member pathways
Signaling Pathways in Glioblastoma38
9.3MET, NRAS, CDKN2A
58.8CDKN2A, NRAS, MET, VIM
6
Show member pathways
8.4VIM, MUC1, MET, NRAS, CDKN2A

Compounds for genes affiliated with Acral Lentiginous Melanoma

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Compounds related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1eosin4510.0MUC1, VIM
2s 1004510.0MUC1, VIM
3reticulin4510.0MUC1, VIM
4mucicarmine4510.0MUC1, VIM
5fluorochrome459.9VIM, TFRC
6b 723459.8VIM, MUC1
7k252a459.8VIM, MET
8temozolomide45 1310.8VIM, CDKN2A
9crcs459.7MUC1, MET, CDKN2A
10leupeptin459.7VIM, TFRC
11doxycycline45 1310.6CDKN2A, TFRC
12dmso459.6TFRC, VIM, MUC1
13hematoxylin459.6CDKN2A, MUC1, VIM
14roscovitine459.5CDKN2A, VIM
15matrigel459.5MET, MUC1, VIM
16methotrexate51 45 1311.5CDKN2A, MUC1, VIM
17chloramphenicol45 3 51 1312.5VIM, MUC1, CDKN2A
1812-o-tetradecanoylphorbol 13-acetate459.5MET, MUC1, VIM
19vitamin d459.4MET, VIM, TFRC
20rapamycin459.3MET, VIM, TFRC
21paclitaxel45 51 1311.3TFRC, VIM, CDKN2A
22wortmannin459.3TFRC, VIM, MET
23cisplatin45 51 61 1312.3TFRC, MUC1, MET, CDKN2A
24glycogen45 2610.3VIM, MUC1, MET
25biotin45 26 1311.2CDKN2A, MUC1, VIM, TFRC
26cytarabine45 51 1311.2TFRC, VIM, MUC1, CDKN2A
27folate459.2CDKN2A, MUC1, VIM, TFRC
28butyrate459.2TFRC, VIM, MUC1, CDKN2A
29glutamine459.2TFRC, VIM, KRT9
30creatinine459.2CDKN2A, MUC1, VIM, TFRC
31doxorubicin45 51 1311.1TFRC, VIM, MET, CDKN2A
32genistein45 30 61 3 26 1314.1CDKN2A, MET, VIM, TFRC
33progesterone45 30 61 26 1313.1VIM, MUC1, MET, CDKN2A
34dexamethasone45 51 30 1312.1TFRC, VIM, MUC1, CDKN2A
35oligonucleotide459.1CDKN2A, NRAS, MET, VIM
36cycloheximide459.1TFRC, VIM, MET, CDKN2A
37alanine459.0TFRC, VIM, MET, CDKN2A
38agar458.9VIM, MUC1, MET, NRAS, CDKN2A
39arginine458.8TFRC, VIM, MET, KRT9, CDKN2A
40iron45 269.8CDKN2A, VIM, TFRC
41adriamycin458.8CDKN2A, MET, MUC1, VIM, TFRC
42actinomycin d458.8TFRC, VIM, MUC1, MET, CDKN2A
43paraffin458.8TFRC, VIM, MUC1, MET, CDKN2A
44testosterone45 61 26 1311.8CDKN2A, MET, MUC1, VIM, TFRC
45vegf458.8CDKN2A, MET, MUC1, VIM, TFRC
46estrogen458.8TFRC, VIM, MUC1, MET, CDKN2A
47retinoic acid45 269.8TFRC, VIM, MUC1, MET, CDKN2A
48cysteine458.8TFRC, VIM, MUC1, MET, CDKN2A
49serine458.7TFRC, VIM, MUC1, MET, CDKN2A

GO Terms for genes affiliated with Acral Lentiginous Melanoma

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Cellular components related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.2CSPG4, MUC1, TFRC
2integral component of plasma membraneGO:00058878.5TFRC, MUC1, MET, CSPG4
3extracellular vesicular exosomeGO:00700628.5KRT9, NRAS, MUC1, VIM, TFRC

Biological processes related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:00451099.7KRT9, VIM

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.7CDKN2A, MUC1
2double-stranded RNA bindingGO:00037259.3VIM, TFRC

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

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4CDC
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27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet