MCID: ACR014
MIFTS: 49

Acral Lentiginous Melanoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Acral Lentiginous Melanoma

MalaCards integrated aliases for Acral Lentiginous Melanoma:

Name: Acral Lentiginous Melanoma 12 49 14
Acral Lentiginous Malignant Melanoma of Skin 49
Acral Lentiginous Melanoma, Malignant 12
Malignant Acral Lentiginous Melanoma 12
Acral Lentiginous Malignant Melanoma 69
Palmar/plantar Melanoma 49
Subungual Melanoma 49
Alm 49

Classifications:



External Ids:

Disease Ontology 12 DOID:6367
UMLS 69 C0346037

Summaries for Acral Lentiginous Melanoma

NIH Rare Diseases : 49 Acral lentiginous melanoma (ALM) is a type of melanoma that occurs on the palms of the hands or the soles of the feet. The condition can develop in normal-appearing skin or within an existing mole. ALM begins as a flat patch of discolored skin that may enlarge slowly over time. Although the cancercells often remain contained at the skins surface (epidermis) initially, ALM can become invasive and spread as the condition advances. Like other flat forms of melanoma, it can be recognized by the ABCDE rule. Although ALM affects men and women of all skin colors equally, is it most commonly diagnosed in people over age 40. The underlying cause of ALM is poorly understood. It is not related to sun exposure like other forms of skin cancer. Initial treatment generally consists of surgery to remove the skin lesion. Additional therapy (such as radiation therapy or immunotherapy) may then be recommended depending on the severity of the condition. Last updated: 4/3/2017

MalaCards based summary : Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to lentigines and melanoma, and has symptoms including macule An important gene associated with Acral Lentiginous Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. The drugs Sunitinib and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Disease Ontology : 12 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

Wikipedia : 72 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. Melanoma is a potentially serious... more...

Related Diseases for Acral Lentiginous Melanoma

Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 lentigines 31.7 BRAF KIT
2 melanoma 29.8 BRAF CDKN2A KIT NRAS PTEN TERT
3 alstrom syndrome 11.2
4 malignant spindle cell melanoma 10.3 KIT NRAS
5 conventional fibrosarcoma 10.3 KIT NRAS
6 bowenoid papulosis 10.3 CDKN2A TERT
7 congenital mesoblastic nephroma 10.2 KIT NRAS
8 melanomatosis 10.2 CDKN2A NRAS
9 malignant skin fibrous histiocytoma 10.2 KIT NRAS
10 erdheim-chester disease 10.2 BRAF NRAS
11 core binding factor acute myeloid leukemia 10.2 KIT NRAS
12 meningeal melanomatosis 10.2 CDKN2A NRAS
13 malignant dermis tumor 10.2 KIT NRAS
14 small cell sarcoma 10.2 CDKN2A NRAS
15 adenoid basal cell carcinoma 10.2 CDKN2A KIT
16 meningeal melanocytoma 10.2 CDKN2A NRAS
17 amelanotic melanoma 10.2 BRAF KIT
18 small cell neuroendocrine carcinoma 10.2 CDKN2A KIT
19 ewing's family of tumors 10.2 CDKN2A KIT
20 spitz nevus 10.2 BRAF CDKN2A
21 sarcoma 10.1
22 necrotizing sialometaplasia 10.1 CDKN2A KIT
23 cervical intraepithelial neoplasia 10.1 CDKN2A TERT
24 mixed type thymoma 10.1 KIT PTEN
25 fibrosarcoma of bone 10.1 CDKN2A KIT
26 gastrointestinal system benign neoplasm 10.1 CDKN2A KIT
27 tumor suppressor gene on chromosome 11 10.1 BRAF PTEN
28 bladder squamous cell carcinoma 10.0 CDKN2A PTEN
29 tongue cancer 10.0 CDKN2A TERT
30 vulvar melanoma 10.0 KIT NRAS TERT
31 blood group, i system 10.0
32 myeloma, multiple 10.0
33 basal cell carcinoma 1 10.0
34 psoriatic arthritis 10.0
35 mycobacterium tuberculosis 1 10.0
36 arthritis 10.0
37 nodular malignant melanoma 10.0
38 tinea pedis 10.0
39 phaeohyphomycosis 10.0
40 basal cell carcinoma 10.0
41 laryngitis 10.0
42 clear cell sarcoma 10.0
43 tinea nigra 10.0
44 lichen planus 10.0
45 lentigo maligna melanoma 10.0
46 lichen planus pigmentosus 10.0
47 superficial spreading melanoma 10.0
48 neurofibroma 10.0 CDKN2A KIT
49 spinal chordoma 10.0 MET TERT
50 suppression of tumorigenicity 12 10.0 BRAF PTEN

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to Acral Lentiginous Melanoma

Symptoms & Phenotypes for Acral Lentiginous Melanoma

UMLS symptoms related to Acral Lentiginous Melanoma:


macule

GenomeRNAi Phenotypes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.23 KIT MET
2 Decreased substrate adherent cell growth GR00193-A-2 9.23 KIT
3 Decreased substrate adherent cell growth GR00193-A-3 9.23 BRAF MET
4 Decreased substrate adherent cell growth GR00193-A-4 9.23 BRAF KIT MET

MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

43 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 NRAS MET CDKN2A BRAF KIT PTEN
2 digestive/alimentary MP:0005381 10.14 MET PTEN NRAS BRAF KIT CDKN2A
3 endocrine/exocrine gland MP:0005379 10.12 MET PTEN NRAS BRAF KIT CDKN2A
4 growth/size/body region MP:0005378 10.11 NRAS MET KIT CDKN2A BRAF TERT
5 behavior/neurological MP:0005386 10.09 KIT NRAS MET CDKN2A BRAF PTEN
6 homeostasis/metabolism MP:0005376 10.09 NRAS MET KIT CDKN2A BRAF TERT
7 cardiovascular system MP:0005385 10.08 NRAS MET KIT CDKN2A BRAF PTEN
8 immune system MP:0005387 10.08 NRAS MET PTEN CDKN2A BRAF KIT
9 embryo MP:0005380 10.06 NRAS MET PTEN CDKN2A BRAF KIT
10 hematopoietic system MP:0005397 10.03 KIT NRAS CDKN2A BRAF TERT PTEN
11 mortality/aging MP:0010768 10.02 NRAS MET KIT CDKN2A BRAF TERT
12 neoplasm MP:0002006 9.98 MET PTEN NRAS BRAF KIT CDKN2A
13 liver/biliary system MP:0005370 9.97 NRAS MET PTEN CDKN2A BRAF KIT
14 integument MP:0010771 9.92 KIT NRAS CDKN2A BRAF PTEN
15 nervous system MP:0003631 9.88 KIT MET CDKN2A BRAF TERT PTEN
16 muscle MP:0005369 9.85 KIT MET CDKN2A BRAF PTEN
17 normal MP:0002873 9.85 NRAS MET BRAF KIT TERT PTEN
18 limbs/digits/tail MP:0005371 9.81 KIT NRAS MET PTEN
19 pigmentation MP:0001186 9.72 NRAS PTEN BRAF KIT CDKN2A
20 reproductive system MP:0005389 9.65 KIT CDKN2A BRAF TERT PTEN
21 respiratory system MP:0005388 9.63 MET PTEN CDKN2A BRAF KIT TERT
22 skeleton MP:0005390 9.43 NRAS KIT CDKN2A BRAF TERT PTEN
23 vision/eye MP:0005391 9.1 NRAS MET PTEN CDKN2A BRAF KIT

Drugs & Therapeutics for Acral Lentiginous Melanoma

Drugs for Acral Lentiginous Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
Pembrolizumab Approved Phase 2 1374853-91-4
3
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
4
Cediranib Investigational Phase 2 288383-20-0 9933475
5
Maleic acid Experimental Phase 2 110-16-7 444266
6 Angiogenesis Inhibitors Phase 2
7 Angiogenesis Modulating Agents Phase 2
8 Imatinib Mesylate Phase 2 123596
9 Protein Kinase Inhibitors Phase 2
10 tyrosine Nutraceutical Phase 2
11
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
12 Anti-Infective Agents Phase 1
13 Antiviral Agents Phase 1
14 Ganciclovir triphosphate Phase 1
15 Nucleic Acid Synthesis Inhibitors Phase 1
16
nivolumab Approved 946414-94-4
17 Antibodies
18 Antibodies, Monoclonal
19 Immunoglobulins

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 A Phase Ⅲ Study to Investigate JS001 Versus Dacarbazine as the First Line Therapy for Unresectable or Metastatic Melanoma Recruiting NCT03430297 Phase 3 Dacarbazine 1000mg/m2 Q3W
2 A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread Completed NCT01395121 Phase 2 nilotinib
3 SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma Completed NCT00577382 Phase 2 Sunitinib
4 Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00470470 Phase 2 imatinib mesylate
5 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
6 Pembrolizumab in Advanced/Metastatic Acral Lentiginous Melanoma Recruiting NCT02875132 Phase 2 pembrolizumab
7 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
8 Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma, Acral Melanoma, or Vulvovaginal Melanoma That Cannot Be Removed By Surgery Active, not recruiting NCT00700882 Phase 2 dasatinib
9 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
10 Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma Terminated NCT01092728 Phase 2 Dasatinib
11 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
12 A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Recruiting NCT02978443 Nivolumab;Ipilimumab
13 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

Anatomical Context for Acral Lentiginous Melanoma

MalaCards organs/tissues related to Acral Lentiginous Melanoma:

38
Skin, Lymph Node, Brain

Publications for Acral Lentiginous Melanoma

Articles related to Acral Lentiginous Melanoma:

(show top 50) (show all 134)
# Title Authors Year
1
Prognostic features for acral lentiginous melanoma. ( 29441559 )
2018
2
High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma. ( 29415335 )
2018
3
Double Primary Acral Lentiginous Melanoma of both Soles. ( 28223769 )
2017
4
Prognostic factors and survival in acral lentiginous melanoma. ( 28432682 )
2017
5
Acral lentiginous melanoma versus other melanoma: A single-center analysis in Japan. ( 28342269 )
2017
6
Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma. ( 28567312 )
2017
7
Overexpression of Human Leukocyte Antigen-G and Interleukin 10 in acral lentiginous melanoma. ( 28587737 )
2017
8
Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma. ( 28224164 )
2017
9
The role of access to care in acral lentiginous melanoma survival. ( 28833024 )
2017
10
Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report. ( 28566910 )
2017
11
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
12
Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America. ( 28577153 )
2017
13
Insulin-Like Growth Factor-II mRNA-Binding Protein 3 as a Novel Prognostic Biomarker for Acral Lentiginous Melanoma. ( 29048737 )
2017
14
Acral lentiginous melanoma - a skin cancer with unfavourable prognostic features. A study of the German Central Malignant Melanoma Registry (CMMR) in 2050 patients. ( 28707317 )
2017
15
Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. ( 27518480 )
2016
16
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma. ( 26796627 )
2016
17
Acral lentiginous melanoma with multiple brain metastases in an Indian male. ( 27559525 )
2016
18
Acral Lentiginous Melanoma. ( 26601870 )
2016
19
Rare cause of non-healing foot wound - acral lentiginous melanoma. Case Report. ( 26994380 )
2016
20
Histopathological diagnosis of acral lentiginous melanoma in early stages. ( 27601330 )
2016
21
Amelanotic acral lentiginous melanoma mimicking diabetic ulcer: a challenge to diagnose and treat. ( 26679765 )
2016
22
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man. ( 26838298 )
2016
23
Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas. ( 26709572 )
2016
24
Reconstruction of large wounds using a combination of negative pressure wound therapy and punch grafting after excision of acral lentiginous melanoma on the foot. ( 26173565 )
2015
25
Screening for Acral Lentiginous Melanoma in Dark-Skinned Individuals. ( 26083954 )
2015
26
IMAGES IN CLINICAL MEDICINE. Acral Lentiginous Melanoma. ( 26535515 )
2015
27
Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer a cautionary case. ( 25815661 )
2015
28
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? ( 25455840 )
2015
29
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. ( 26588333 )
2015
30
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma. ( 26088594 )
2015
31
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. ( 25773399 )
2015
32
Reflectance confocal microscopy features of acral lentiginous melanoma: a comparative study with acral nevi. ( 26428577 )
2015
33
Acral lentiginous melanoma: indolent subtype with long radial growth phase. ( 24556899 )
2014
34
Two Spanish cases of Atypical Melanosis of the Foot, an early stage of Acral Lentiginous Melanoma in situ. ( 25323966 )
2014
35
Recurrent acral lentiginous melanoma in situ suggesting the field cell theory. ( 25473243 )
2014
36
TERT promoter mutation is uncommon in acral lentiginous melanoma. ( 24588324 )
2014
37
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. ( 25396085 )
2014
38
Prognostic and Clinicopathologic Associations of BRAF Mutation in Primary Acral Lentiginous Melanoma in Korean Patients: A Preliminary Study. ( 24882974 )
2014
39
Laryngeal metastases of acral lentiginous melanoma: Narrow band imaging. ( 25488159 )
2014
40
Indolent Subtype Acral Lentiginous Melanoma With Long Radial Growth Phase: A Dermatopathological Pitfall. ( 25072690 )
2014
41
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. ( 25252087 )
2014
42
TERT gene amplification is associated with poor outcome in acral lentiginous melanoma. ( 25219713 )
2014
43
Acral Lentiginous Melanoma - Misdiagnosis, referral delay and 5 years specific survival according to site. ( 25027337 )
2014
44
Clinical presentation of acral lentiginous melanoma: a descriptive study. ( 22959666 )
2013
45
KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma. ( 23993026 )
2013
46
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. ( 22931051 )
2013
47
Conservative surgical treatment of a thin acral lentiginous melanoma of the thumb with no recurrences: a case report. ( 23742286 )
2013
48
Genetic alterations in RAS-regulated pathway in acral lentiginous melanoma. ( 23362874 )
2013
49
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? ( 24249911 )
2013
50
Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. ( 23362968 )
2013

Variations for Acral Lentiginous Melanoma

Cosmic variations for Acral Lentiginous Melanoma:

9 (show top 50) (show all 63)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM1166809 PTEN skin,acral,malignant melanoma,acral lentiginous c.333G>A p.W111* 22
2 COSM584 NRAS skin,acral,malignant melanoma,acral lentiginous c.182A>G p.Q61R 22
3 COSM1255 KIT skin,acral,malignant melanoma,acral lentiginous c.1676T>C p.V559A 22
4 COSM6503445 KIT skin,acral,malignant melanoma,acral lentiginous c.1658A>C p.Y553S 22
5 COSM1290 KIT skin,acral,malignant melanoma,acral lentiginous c.1727T>C p.L576P 22
6 COSM18682 KIT skin,acral,malignant melanoma,acral lentiginous c.2468A>G p.Y823C 22
7 COSM1257 KIT skin,acral,malignant melanoma,acral lentiginous c.1679T>A p.V560D 22
8 COSM1430154 KIT skin,acral,malignant melanoma,acral lentiginous c.1715A>G p.D572G 22
9 COSM6503446 KIT skin,acral,malignant melanoma,acral lentiginous c.1733A>G p.Y578C 22
10 COSM235682 KIT skin,acral,malignant melanoma,acral lentiginous c.1965T>G p.N655K 22
11 COSM460 BRAF skin,acral,malignant melanoma,acral lentiginous c.1406G>C p.G469A 22
12 COSM29529 RB1 skin,NS,malignant melanoma,acral lentiginous c.1411C>T p.Q471* 14
13 COSM562 NRAS skin,NS,malignant melanoma,acral lentiginous c.34G>T p.G12C 14
14 COSM564 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 14
15 COSM583 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>T p.Q61L 14
16 COSM580 NRAS skin,NS,malignant melanoma,acral lentiginous c.181C>A p.Q61K 14
17 COSM565 NRAS skin,acral,malignant melanoma,NS c.35G>C p.G12A 14
18 COSM3724522 NRAS skin,NS,malignant melanoma,acral lentiginous c.184G>C p.E62Q 14
19 COSM577 NRAS skin,NS,malignant melanoma,acral lentiginous c.52G>A p.A18T 14
20 COSM586 NRAS skin,NS,malignant melanoma,acral lentiginous c.183A>C p.Q61H 14
21 COSM573 NRAS skin,NS,malignant melanoma,acral lentiginous c.38G>A p.G13D 14
22 COSM566 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>T p.G12V 14
23 COSM563 NRAS skin,NS,malignant melanoma,acral lentiginous c.34G>A p.G12S 14
24 COSM569 NRAS skin,acral,malignant melanoma,NS c.37G>C p.G13R 14
25 COSM253327 NRAS skin,acral,malignant melanoma,NS c.176C>A p.A59D 14
26 COSM521 KRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 14
27 COSM1321 KIT skin,acral,malignant melanoma,NS c.2466T>A p.N822K 14
28 COSM1651644 KIT skin,NS,malignant melanoma,acral lentiginous c.2449A>C p.I817L 14
29 COSM1304 KIT skin,NS,malignant melanoma,acral lentiginous c.1924A>G p.K642E 14
30 COSM144520 KIT skin,acral,malignant melanoma,NS c.1694G>A p.G565E 14
31 COSM133765 KIT skin,acral,malignant melanoma,NS c.1898A>G p.E633G 14
32 COSM1273 KIT skin,acral,malignant melanoma,NS c.1696A>G p.N566D 14
33 COSM36305 KIT skin,acral,malignant melanoma,NS c.1745G>A p.W582* 14
34 COSM133756 KIT skin,acral,malignant melanoma,NS c.2542T>C p.F848L 14
35 COSM133755 KIT skin,acral,malignant melanoma,NS c.1469A>G p.E490G 14
36 COSM144512 KIT skin,NS,malignant melanoma,acral lentiginous c.1904A>G p.E635G 14
37 COSM133767 KIT skin,acral,malignant melanoma,NS c.2558G>A p.W853* 14
38 COSM133763 KIT skin,acral,malignant melanoma,NS c.1657T>A p.Y553N 14
39 COSM133760 KIT skin,acral,malignant melanoma,NS c.1942G>A p.G648S 14
40 COSM133780 KIT skin,acral,malignant melanoma,NS c.2531G>A p.C844Y 14
41 COSM1651643 KIT skin,NS,malignant melanoma,acral lentiginous c.1420G>A p.V474I 14
42 COSM133774 KIT skin,acral,malignant melanoma,NS c.1687A>G p.I563V 14
43 COSM133757 KIT skin,acral,malignant melanoma,NS c.2486C>T p.A829V 14
44 COSM29015 KIT skin,acral,malignant melanoma,NS c.1673A>G p.K558R 14
45 COSM250098 KIT skin,acral,malignant melanoma,NS c.1656G>A p.M552I 14
46 COSM133762 KIT skin,acral,malignant melanoma,NS c.2450T>C p.I817T 14
47 COSM33966 KIT skin,acral,malignant melanoma,NS c.1726C>T p.L576F 14
48 COSM33972 KIT skin,NS,malignant melanoma,acral lentiginous c.1915T>C p.S639P 14
49 COSM1219 KIT skin,acral,malignant melanoma,NS c.1669T>C p.W557R 14
50 COSM133769 KIT skin,acral,malignant melanoma,NS c.2576T>C p.L859P 14

Expression for Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for Acral Lentiginous Melanoma

Pathways related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 BRAF CDKN2A KIT MET NRAS PTEN
2
Show member pathways
13.42 BRAF CDKN2A KIT MET NRAS PTEN
3
Show member pathways
12.72 BRAF KIT MET NRAS PTEN
4
Show member pathways
12.7 BRAF MET NRAS PTEN
5
Show member pathways
12.69 BRAF MET NRAS PTEN
6
Show member pathways
12.65 BRAF KIT MET NRAS
7
Show member pathways
12.62 BRAF CDKN2A KIT MET NRAS PTEN
8
Show member pathways
12.59 KIT MET NRAS PTEN TERT
9
Show member pathways
12.58 BRAF NRAS PTEN
10 12.55 BRAF KIT MET NRAS
11
Show member pathways
12.51 BRAF KIT MET NRAS
12
Show member pathways
12.5 KIT MET NRAS PTEN
13
Show member pathways
12.48 BRAF MET NRAS PTEN
14
Show member pathways
12.37 BRAF CDKN2A NRAS
15
Show member pathways
12.28 BRAF MET NRAS
16 12.27 CDKN2A MET NRAS PTEN
17 12.23 CDKN2A NRAS TERT
18
Show member pathways
12.22 BRAF MET NRAS PTEN
19 12.22 BRAF CDKN2A KIT MET NRAS PTEN
20
Show member pathways
12.19 BRAF NRAS PTEN
21 12.12 BRAF MET NRAS
22 12 CDKN2A NRAS PTEN
23
Show member pathways
11.97 BRAF CDKN2A NRAS
24
Show member pathways
11.96 BRAF MET NRAS PTEN
25
Show member pathways
11.92 BRAF NRAS PTEN
26
Show member pathways
11.83 BRAF CDKN2A KIT MET NRAS PTEN
27 11.81 CDKN2A NRAS PTEN
28 11.74 BRAF CDKN2A PTEN
29 11.67 BRAF CDKN2A NRAS PTEN
30
Show member pathways
11.62 BRAF KIT NRAS
31 11.55 BRAF CDKN2A NRAS
32 11.45 BRAF NRAS
33 11.29 BRAF NRAS
34 11.27 KIT MET NRAS PTEN
35 11.19 BRAF NRAS
36 11.12 MET NRAS
37 11.12 NRAS PTEN

GO Terms for Acral Lentiginous Melanoma

Cellular components related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 KIT PTEN

Biological processes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.73 BRAF CDKN2A KIT MET
2 positive regulation of gene expression GO:0010628 9.62 BRAF CDKN2A KIT PTEN
3 visual learning GO:0008542 9.52 BRAF KIT
4 long-term synaptic potentiation GO:0060291 9.51 BRAF PTEN
5 cellular response to nerve growth factor stimulus GO:1990090 9.49 BRAF PTEN
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 BRAF TERT
7 response to cadmium ion GO:0046686 9.46 KIT TERT
8 replicative senescence GO:0090399 9.4 CDKN2A TERT
9 somatic stem cell division GO:0048103 9.37 CDKN2A KIT
10 regulation of axon regeneration GO:0048679 9.26 BRAF PTEN
11 myeloid progenitor cell differentiation GO:0002318 9.16 BRAF KIT
12 regulation of protein stability GO:0031647 9.13 CDKN2A PTEN TERT
13 MAPK cascade GO:0000165 8.92 BRAF KIT MET NRAS

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 BRAF MET PTEN TERT
2 kinase activity GO:0016301 9.26 BRAF CDKN2A KIT MET
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KIT MET
4 nucleotide binding GO:0000166 8.92 BRAF KIT MET NRAS

Sources for Acral Lentiginous Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....