ALM
MCID: ACR014
MIFTS: 42

Acral Lentiginous Melanoma (ALM) malady

Skin diseases category

Summaries for Acral Lentiginous Melanoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. more...

MalaCards: Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and multiple myeloma. An important gene associated with Acral Lentiginous Melanoma is KRT9 (keratin 9), and among its related pathways are Glioma and GPCR Pathway. The compounds creatinine and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Acral Lentiginous Melanoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

acral lentiginous melanoma 8 42 10
acral lentiginous malignant melanoma of skin 42
acral lentiginous melanoma, malignant 8
acral lentiginous malignant melanoma 60
malignant acral lentiginous melanoma 8
palmar/plantar melanoma 42
subungual melanoma 42
alm 42


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Disease Ontology8 DOID:6367

Related Diseases for Acral Lentiginous Melanoma

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17GeneCards, 18GeneDecks
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Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.8VIM, CSPG4, TFRC, MET, NRAS, ANKRD36B
2multiple myeloma30.4CDKN2A
3myeloma30.4MET, TFRC
4sarcoma30.4MUC1, NRAS, MET, VIM
5skin melanoma10.5
6tinea nigra10.3
7psoriatic arthritis10.3
8lichen planus10.3
9clear cell sarcoma10.3
10tinea pedis10.3
11arthritis10.3
12basal cell carcinoma10.3
13tuberculosis10.3
14alstrom syndrome10.2
15amelanotic melanoma10.1
16neuronitis10.0
17ocular melanoma10.0ANKRD36B
18gliosarcoma10.0TFRC
19endometriosis10.0TFRC
20thyroid cancer10.0MET
21kidney cancer10.0MET
22hepatoblastoma10.0MET
23von hippel-lindau disease10.0MET
24biliary tract neoplasm10.0MET
25acute leukemia10.0TFRC
26eccrine porocarcinoma10.0MUC1
27angiomyolipoma10.0VIM
28fibrosarcoma10.0VIM
29hidradenoma10.0MUC1
30wilms tumor10.0VIM
31syringoma10.0MUC1
32myeloid leukemia10.0TFRC
33liposarcoma10.0VIM
34adenomatoid tumor10.0VIM
35adenocarcinoma in situ10.0CDKN2A
36gastrointestinal stromal tumor10.0VIM
37epidermolysis bullosa simplex10.0KRT9
38glomus tumor10.0VIM
39sertoli-leydig cell tumor10.0MUC1
40papilloma10.0CDKN2A
41gallbladder cancer10.0NRAS
42bladder carcinoma10.0CDKN2A, TFRC
43pancreatitis10.0NRAS
44familial adenomatous polyposis10.0NRAS
45glioblastoma multiforme10.0MET, CDKN2A
46chordoma10.0MUC1, VIM
47leiomyosarcoma10.0MUC1, VIM
48proliferative vitreoretinopathy10.0TFRC, MET
49rhabdoid tumor10.0MUC1, VIM
50osteosarcoma10.0MET, CDKN2A

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to acral lentiginous melanoma

Clinical Features for Acral Lentiginous Melanoma

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Drugs & Therapeutics for Acral Lentiginous Melanoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acral Lentiginous Melanoma

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Anatomical Context for Acral Lentiginous Melanoma

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32MalaCards
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MalaCards organs/tissues related to Acral Lentiginous Melanoma:

32
Skin, Lymph node

Animal Models for Acral Lentiginous Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.8MUC1, VIM
2MP:00053768.7CSPG4, TFRC, NRAS, PLD1
3MP:00020068.4MET, NRAS, MUC1, CDKN2A, PLD1
4MP:00053818.3TFRC, MET, NRAS, MUC1, CDKN2A
5MP:00030128.2CDKN2A, MUC1, NRAS, MET, CSPG4
6MP:00053708.1CDKN2A, MUC1, NRAS, MET, TFRC, CSPG4

Publications for Acral Lentiginous Melanoma

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50PubMed
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Articles related to Acral Lentiginous Melanoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Acral lentiginous melanoma of the toe treated using Mohs surgery with sparing of the digit and subsequent reconstruction using split-thickness skin graft. (22931051)
2013
2
Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. (23362968)
2013
3
Conservative surgical treatment of a thin acral lentiginous melanoma of the thumb with no recurrences: a case report. (23742286)
2013
4
Unique prognostic factors in acral lentiginous melanoma. (23022254)
2012
5
Consumption of the epidermis in acral lentiginous melanoma. (22574622)
2012
6
Traumatic Hematoma in a Palmoplantar wart Mimicking Acral Lentiginous Melanoma. (23060711)
2012
7
Acral pigmented spitz nevus that clinically mimicked acral lentiginous malignant melanoma. (21747632)
2011
8
Comparison of secondary intention healing and full-thickness skin graft after excision of acral lentiginous melanoma on foot. (21615605)
2011
9
Acral lentiginous melanoma: a case control study and guidelines update. (21541184)
2011
10
Acral Lentiginous Melanoma Developing during Long-standing Atypical Melanosis: Usefulness of Dermoscopy for Detection of Early Acral Melanoma. (21909219)
2011
11
Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb. (20545949)
2011
12
Acral lentiginous melanoma in situ: a diagnostic and management challenge. (24281086)
2010
13
Unilateral lichen planus pigmentosus mimicking acral lentiginous melanoma. (20677541)
2010
14
The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. (20448346)
2010
15
Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. (18758972)
2009
16
Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ. (18384603)
2008
17
Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. (17999703)
2008
18
Sun and melanoma: What about acral lentiginous melanoma? (18684760)
2008
19
Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. (17083858)
2006
20
Case of the month. Pigmented acral-lentiginous melanoma (ALM). (16483079)
2006
21
Acral lentiginous melanoma mimicking benign disease: the Emory experience. (12582386)
2003
22
Acral-lentiginous melanoma. (10881468)
2000
23
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma. (10657449)
2000
24
Differential clinical significance of alpha(v)Beta(3) expression in primary lesions of acral lentiginous melanoma and of other melanoma histotypes. (10754493)
2000
25
Acral lentiginous melanoma. (20877020)
2000
26
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. (10434891)
1999
27
Acral lentiginous melanoma. (9879051)
1998
28
Acral lentiginous melanoma of the palm. (9136165)
1996
29
Acral lentiginous melanoma (including in situ melanoma) arising in association with naevocellular naevi. (8819127)
1996
30
Acral lentiginous melanoma. A histological type without prognostic significance. (7798414)
1994
31
Acral lentiginous melanoma associated with Down's syndrome. (8482754)
1993
32
Association of high molecular weight melanoma-associated antigen expression in primary acral lentiginous melanoma lesions with poor prognosis. (8504426)
1993
33
Acral lentiginous melanoma: case studies from Kauai. (1428854)
1992
34
Ganglioside expression of human melanoma and tumor progression. Ganglioside composition of a plaque and a nodule of acral lentiginous melanoma. (1409417)
1992
35
Acral lentiginous melanoma in situ. (1352141)
1992
36
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. (1671829)
1991
37
Acral lentiginous melanoma. Pedal lesions in the black population. (3246658)
1988
38
Acral lentiginous melanoma. A report of a case and a review of the literature. (3681672)
1987
39
Tinea nigra masquerading as acral lentiginous melanoma. (3700830)
1986
40
Pigmented freckles on the sole of acral lentiginous melanoma in situ. (3908530)
1985
41
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
42
Acral lentiginous melanoma and lentigo maligna occurring in Werner's syndrome. (6627991)
1983
43
Acral lentiginous melanoma of the penis. (7075635)
1982
44
The color of the skin of the palms and soles as a possible clue to the pathogenesis of acral-lentiginous melanoma. (7149195)
1982
45
Acral lentiginous melanoma. A clinicopathologic entity. (7073361)
1982
46
Dermatology-epitomes of progress: acral lentiginous melanoma. (18748764)
1981
47
Acral lentiginous melanoma. (7389397)
1980
48
Acral lentiginous melanoma. (7396539)
1980
49
Acral lentiginous melanoma. (7447295)
1980
50
A darkly pigmented lesion of a great toe (acral lentiginous melanoma). (864073)
1977

Genetic Variations for Acral Lentiginous Melanoma

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Expression for genes affiliated with Acral Lentiginous Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for genes affiliated with Acral Lentiginous Melanoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Acral Lentiginous Melanoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1creatinine4410.3CDKN2A
2eosin4410.1MUC1, VIM
3s 1004410.1MUC1, VIM
4fluorochrome4410.1TFRC, VIM
5reticulin4410.0VIM, MUC1
6mucicarmine4410.0MUC1, VIM
7temozolomide44 1110.8CDKN2A, VIM
8crcs449.8MET, MUC1, CDKN2A
9dmso449.7VIM, TFRC, MUC1
10k252a449.7VIM, MET
11hematoxylin449.7CDKN2A, MUC1, VIM
12b 723449.5MUC1, VIM
13cytarabine44 49 1111.4VIM, TFRC, MUC1, CDKN2A
14methotrexate44 49 1111.4VIM, MUC1, CDKN2A
15biotin44 11 2411.4CDKN2A, MUC1, TFRC, VIM
16folate449.4CDKN2A, MUC1, TFRC, VIM
17doxorubicin44 49 1111.4CDKN2A, MET, TFRC, VIM
18cisplatin44 49 59 1112.4CDKN2A, MUC1, MET, TFRC
19genistein44 28 59 2 11 2414.3VIM, TFRC, MET, CDKN2A
20chloramphenicol44 2 1111.3CDKN2A, MUC1, VIM
2112-o-tetradecanoylphorbol 13-acetate449.3VIM, MET, MUC1, PLD1
22progesterone44 59 28 11 2413.2CDKN2A, MUC1, MET, VIM
23adriamycin449.1CDKN2A, MUC1, MET, TFRC, VIM
24arginine449.1VIM, TFRC, MET, CDKN2A, KRT9
25actinomycin d449.1VIM, TFRC, MET, MUC1, CDKN2A
26paraffin449.1CDKN2A, MUC1, MET, TFRC, VIM
27testosterone44 59 11 2412.1VIM, TFRC, MET, MUC1, CDKN2A
28vegf449.0VIM, TFRC, MET, MUC1, CDKN2A
29h2o2449.0VIM, TFRC, CDKN2A, PLD1
30estrogen449.0VIM, TFRC, MET, MUC1, CDKN2A
31agar449.0VIM, MET, NRAS, MUC1, CDKN2A
32oligonucleotide448.9CDKN2A, NRAS, MET, VIM
33cholesterol44 28 11 2411.9PLD1, CDKN2A, MUC1, MET
34cycloheximide448.9VIM, TFRC, MET, CDKN2A, PLD1
35alanine448.8VIM, TFRC, MET, CDKN2A, PLD1
36lipid448.6PLD1, CDKN2A, MUC1, MET, VIM
37retinoic acid44 249.5VIM, TFRC, MET, MUC1, CDKN2A, PLD1
38cysteine448.5VIM, TFRC, MET, MUC1, CDKN2A, PLD1

GO Terms for genes affiliated with Acral Lentiginous Melanoma

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16Gene Ontology
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Biological processes related to Acral Lentiginous Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.8KRT9, VIM
2Ras protein signal transductionGO:0072658.8PLD1, CDKN2A, NRAS

Products for genes affiliated with Acral Lentiginous Melanoma

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Sources for Acral Lentiginous Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet