MCID: ACR015
MIFTS: 38

Acrocephalosyndactylia malady

Category: Bone diseases

Aliases & Classifications for Acrocephalosyndactylia

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Aliases & Descriptions for Acrocephalosyndactylia:

Name: Acrocephalosyndactylia 11 13 37
 
Apert Syndrome 11

Classifications:



External Ids:

Disease Ontology11 DOID:12960
ICD9CM30 755.55
MeSH37 D000168
NCIt43 C34348

Summaries for Acrocephalosyndactylia

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Wikipedia:69 Acrocephalosyndactylia (or acrocephalosyndactyly) is the common presentation of craniosynostosis and... more...

MalaCards based summary: Acrocephalosyndactylia, also known as apert syndrome, is related to apert syndrome and pfeiffer syndrome. An important gene associated with Acrocephalosyndactylia is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and Angiogenesis (CST). Affiliated tissues include bone, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Disease Ontology:11 A synostosis that results in craniosynostosis and syndactyly.

Related Diseases for Acrocephalosyndactylia

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Diseases related to Acrocephalosyndactylia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1apert syndrome33.8FGFR2, FGFR3, RAB23
2pfeiffer syndrome11.3
3maroteaux fonfria syndrome11.0
4pfn1-related amyotrophic lateral sclerosis10.5FGFR1, FGFR2
5staphylococcal scarlet fever10.5FGFR3, TWIST1
6uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis10.5FGFR1, FGFR2
7mite infestation10.4FGFR2, FGFR3
8accommodative esotropia10.4FGFR2, FGFR3
9conjunctiva squamous cell carcinoma10.4FGF10, FGFR2
10weill-marchesani syndrome10.4FGFR1, FGFR2
11osteopetrosis and infantile neuroaxonal dystrophy10.3FGFR1, FGFR3
12glaucomatocyclitic crisis10.3FGFR2, FGFR3
13pallister-hall syndrome10.2GLI3, PGAM2
14flnb-related disorders10.2FGFR1, FGFR2, FGFR3
15trigonocephaly 110.2FGFR1, FGFR2, FGFR3
16peritoneum cancer10.2FGF10, FGFR2
17hypogonadotropic hypogonadism 2 with or without anosmia10.2FGFR1, FGFR2, FGFR3
18serous conjunctivitis except viral10.2FGFR2, FGFR3, GLI3
19thanatophoric dysplasia, type i10.2FGFR1, FGFR2, FGFR3
20syphilitic myelopathy10.2FGFR1, FGFR3, GLI3
21hypochondroplasia10.2FGFR1, FGFR2, FGFR3
22adult astrocytic tumour10.1FGFR1, FGFR3, TWIST1
23syndactyly10.1
24scleredema adultorum10.1FGFR2, FGFR3
25craniosynostosis10.1
26crouzon syndrome10.0
27white matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome10.0
28plasmalogens synthesis deficiency isolated9.9FGFR1, FGFR2, FGFR3, TWIST1
29bladder cancer, somatic9.9FGFR1, FGFR2, FGFR3, TWIST1
30crouzon syndrome with acanthosis nigricans9.9FGF13, FGFR2, FGFR3
31acne9.9
32omphalocele9.9
33polydactyly9.9
34synostosis9.9
35polyhydramnios9.9
36orbital granuloma9.9MSX2, TWIST1
37nail disorder, nonsyndromic congenital, 19.9FGF13, FGFR1
38saethre-chotzen syndrome9.9
39greig cephalopolysyndactyly syndrome9.9
40carpenter syndrome9.9
41acrocephalopolysyndactyly type iii9.9
42grade iii astrocytoma9.8FGFR1, FGFR3
43glycogen storage disease ix9.8FGF10, FGFR1, FGFR2, GLI3
44antley-bixler syndrome without genital anomalies or disordered steroidogenesis9.8FGF10, FGFR1, FGFR2, FGFR3
45gastroesophageal reflux9.8
46sleep apnea9.8
47obstructive sleep apnea9.8
48humeroradial synostosis9.8
49cervicitis9.8
50papillary carcinoma9.8

Graphical network of the top 20 diseases related to Acrocephalosyndactylia:



Diseases related to acrocephalosyndactylia

Symptoms for Acrocephalosyndactylia

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Drugs & Therapeutics for Acrocephalosyndactylia

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Drugs for Acrocephalosyndactylia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ClopidogrelPhase 3, Phase 2733120202-66-6, 113665-84-260606
Synonyms:
( )-(S)-Clopidogrel
(+)-(S)-Clopidogrel
(+)-Clopidogrel
(S)-Clopidogrel
(S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
113665-84-2
AC-19024
AC1L1TKZ
AC1Q41I9
BIDD:GT0284
BRD-K27721098-065-02-9
BSPBio_003211
C16H16ClNO2S
CGE
CHEBI:37941
CHEMBL1771
CID60606
CLOPIDOGREL SULFATE
CPD000550475
Clopidogrel
Clopidogrel (INN)
Clopidogrel (TN)
Clopidogrel [BAN:INN]
Clopidogrel [Ban:Inn]
Clopidogrel [INN:BAN]
Clopidogrel bisulfate
Clopidogrel bisulphate
Clopidogrel sulfate
Clopidogrelum
D07729
DB00758
DivK1c_000787
HMS2090O21
HMS502H09
HSDB 7430
IDI1_000787
 
Isocover
KBio1_000787
KBio2_000545
KBio2_003113
KBio2_005681
KBio3_002431
KBioGR_000689
KBioSS_000545
LS-172232
MLS001165708
MLS001195633
MLS001304711
Methyl (+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4H)-acetate
MolPort-002-885-817
MolPort-003-845-991
NCGC00163329-02
NINDS_000787
Plavix
Plavix (TN)
SAM002589956
SMR000550475
SPBio_000463
SR 25990
STK580572
STOCK5S-27782
Spectrum2_000512
Spectrum3_001606
Spectrum4_000175
Spectrum_000105
TL8000400
UNII-A74586SNO7
Zyllt
clopidogrel
clopidogrel, (+)(S)-isomer
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate
methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
nchem.651-comp8
2
TiclopidinePhase 3, Phase 243555142-85-35472
Synonyms:
5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine
55142-85-3
AC-15204
AC1L1KFB
BIDD:PXR0169
BPBio1_000191
BRD-K00603606-003-03-4
BRN 1216802
BSPBio_000173
C07140
C14H14ClNS
CAS-53885-35-1
CHEBI:9588
CHEMBL833
CID5472
D08594
DB00208
EINECS 259-498-5
HMS2089I18
L001108
LS-152434
MLS001201825
MolPort-002-507-849
 
NCGC00016872-01
NCGC00016872-02
NCGC00024361-04
PCR 5332
Prestwick0_000047
Prestwick1_000047
Prestwick2_000047
Prestwick3_000047
SMR000641861
SPBio_002094
STK589340
STOCK5S-54105
Ticlid
Ticlopidin-Puren
Ticlopidin-Puren (TN)
Ticlopidina
Ticlopidina [INN-Spanish]
Ticlopidine (INN)
Ticlopidine HCL
Ticlopidine Hydrochloride
Ticlopidine [INN:BAN]
Ticlopidinum
Ticlopidinum [INN-Latin]
UNII-OM90ZUW7M1
UNM-0000345023
ZINC19594599
ticlopidine
3
TicagrelorPhase 3, Phase 2288274693-27-59871419
Synonyms:
(1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-D)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
AZD 6140
 
AZD-6140
AZD6140
Brilinta
4
protease inhibitorsPhase 25157
Synonyms:
 
protease inhibitors
5
HeparinPhase 27799005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
6
OtamixabanPhase 25193153-04-7
Synonyms:
193153-04-7
1ksn
2-(3-Carbamimidoylbenzyl)-3-(4-(1-oxypyridin-4-yl)benzoylamino)butyric acid methyl ester
AC1NUYXM
 
CHEBI:167105
CHEMBL46618
CID5496659
Methyl 2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-4-yl)benzoyl]amino]butanoate
Otamixaban
methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-1-ium-4-yl)benzoyl]amino]butanoate
7
EptifibatidePhase 229188627-80-7123610
Synonyms:
148031-34-9
157630-07-4
188627-80-7
2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid
2-[20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid
AC1L3WYY
AC1L9MDI
BIDD:GT0422
C35H49N11O9S2
C68-22
CHEBI:291902
CHEMBL1174
CID123610
CID448812
Eptifibatide
FT-0082227
 
HS-2011
I06-0351
Integrelin
Integrilin
Intrifiban
L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic (1-6)-disulfide
L-Cysteinamide,N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-propyl-,cyclic (1-6)-disulfide
LS-173318
LS-182837
N(6)-amidino-N(2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide
N(sup 6)-Amidino-N(sup 2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide
NCGC00167505-01
S(1),S(6)-cyclo[N(6)-carbamimidoyl-N(2)-(3-sulfanylpropanoyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide]
SB-1
Sch-60936
UNII-NA8320J834
[(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
nchembio829-comp11
8calcium heparinPhase 2779
9
RivaroxabanPhase 2233366789-02-8
Synonyms:
BAY 59-7939
 
BAY59-7939
Xarelto
10
AspirinPhase 2107450-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
 
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
11serineNutraceuticalPhase 2883
12calcium channel blockers1889
13
Amlodipine46488150-42-92162
Synonyms:
()-Amlodipine
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
88150-42-9
88150-47-4 (maleate (1:1))
AC-4535
AC1L1D26
AC1Q32ZS
AMLODIPINE BASE
AMVAZ
Ambap88150-42-9
Amlocard
Amlodipine
Amlodipine (INN)
Amlodipine Benzenesulfonate
Amlodipine Besilate
Amlodipine Besylate
Amlodipine Free Base
Amlodipine [INN:BAN]
Amlodipine besilate
Amlodipine besylate
Amlodipine free base
Amlodipino
Amlodipino [Spanish]
Amlodipinum
Amlodipinum [Latin]
Amlodis
Amlopres
Amlor
 
Amvaz
BIDD:GT0810
BRD-A22032524-074-02-4
BRD-A22032524-074-03-2
BSPBio_002727
C06825
CHEBI:2668
CHEMBL1491
CID2162
CPD000469198
Coroval
D07450
DB00381
HMS2052N03
HMS2089H07
I14-0798
Intervask
Istin
KBio3_001947
KBioGR_001643
LS-131183
Lipinox
Lotrel
MLS001401409
MolPort-001-792-963
NCGC00165957-01
NCGC00165957-02
NCGC00165957-03
Norvasc
Norvasc (TN)
Pelmec
R,S)-Amlodipine
Racemic Amlodipine
SAM001246705
SMR000469198
SPBio_000351
Spectrum2_000486
Spectrum3_001004
Spectrum4_001132
Spectrum5_001550
UK-4834011
UNII-1J444QC288
amlodipine

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACSRecruitingNCT02415803Phase 3
2Feasibility Assessment of ACS CatheterWithdrawnNCT01960517Phase 2, Phase 3
3Study of Otamixaban Versus Unfractionated Heparin (UFH) and Eptifibatide in Non-ST Elevation Acute Coronary SyndromeCompletedNCT00317395Phase 2
4A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary SyndromeActive, not recruitingNCT02293395Phase 2
5PCI and Renal Denervation in Hypertensive Patients With Acute Coronary SyndromesNot yet recruitingNCT02272920Phase 2
6Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial DifferencesCompletedNCT00340964
7Dairy Products and Metabolic Effects (Norwegian Part)CompletedNCT00140816
8Azilsartan Circadian and Sleep PressureCompletedNCT01762501
9European Quality Improvement Programme for Acute Coronary SyndromesRecruitingNCT00716430

Search NIH Clinical Center for Acrocephalosyndactylia


Cochrane evidence based reviews: acrocephalosyndactylia

Genetic Tests for Acrocephalosyndactylia

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Anatomical Context for Acrocephalosyndactylia

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MalaCards organs/tissues related to Acrocephalosyndactylia:

34
Bone

Animal Models for Acrocephalosyndactylia or affiliated genes

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MGI Mouse Phenotypes related to Acrocephalosyndactylia:

39 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7FGF10, FGFR1, FGFR2, FGFR3, GLI3
2MP:00053778.4FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
3MP:00053828.0FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
4MP:00107717.9FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
5MP:00053807.9FGF10, FGFR1, FGFR2, GLI3, MSX2, RAB23
6MP:00053817.8FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
7MP:00053917.6FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
8MP:00053907.2FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
9MP:00053867.2FGF10, FGF13, FGFR1, FGFR2, FGFR3, MSX2
10MP:00053716.9FGF10, FGFR1, FGFR2, FGFR3, GLI3, MSX2
11MP:00107686.7FGF10, FGF13, FGFR1, FGFR2, FGFR3, GLI3
12MP:00036316.7FGF10, FGF13, FGFR1, FGFR2, FGFR3, GLI3

Publications for Acrocephalosyndactylia

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Articles related to Acrocephalosyndactylia:

idTitleAuthorsYear
1
Acrocephalosyndactylia associated with a chromosomal translocation. 46,XX, t (2p-; Cq+). (5493837)
1970
2
Acrocephalosyndactylia: two case reports. (13594964)
1958

Variations for Acrocephalosyndactylia

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Expression for genes affiliated with Acrocephalosyndactylia

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Search GEO for disease gene expression data for Acrocephalosyndactylia.

Pathways for genes affiliated with Acrocephalosyndactylia

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Pathways related to Acrocephalosyndactylia according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathwaysScoreTop Affiliating Genes
19.5FGFR1, FGFR2, FGFR3
2
Show member pathways
9.5FGFR1, FGFR2, FGFR3
39.5FGFR1, FGFR2, FGFR3
4
Show member pathways
9.5FGFR1, FGFR2, FGFR3
59.5FGFR1, FGFR2, FGFR3
6
Show member pathways
9.5FGFR1, FGFR2, FGFR3
79.5FGFR1, FGFR2, FGFR3
89.5FGFR1, FGFR3, GLI3
99.3FGF10, FGFR1, FGFR3
10
Show member pathways
9.0FGF10, FGFR1, FGFR2, FGFR3
11
Show member pathways
9.0FGF10, FGFR1, FGFR2, FGFR3
12
Show member pathways
9.0FGF10, FGFR1, FGFR2, FGFR3
13
Show member pathways
9.0FGF10, FGFR1, FGFR2, FGFR3
149.0FGFR1, FGFR2, FGFR3, PGAM2
15
Show member pathways
8.8FGF10, FGF13, FGFR1, FGFR2
16
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
17
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
188.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
19
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
20
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
21
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
22
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
23
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
248.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
258.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
26
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
278.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
28
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
29
Show member pathways
8.4FGF10, FGF13, FGFR1, FGFR2, FGFR3
308.3FGFR1, FGFR2, FGFR3, MSX2, TWIST1
318.1FGF10, FGF13, FGFR1, FGFR2, FGFR3, GLI3

GO Terms for genes affiliated with Acrocephalosyndactylia

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Cellular components related to Acrocephalosyndactylia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.4FGF10, FGF13, FGFR1, FGFR2, FGFR3, GLI3

Biological processes related to Acrocephalosyndactylia according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.6FGFR1, FGFR2
2outer ear morphogenesisGO:004247310.5FGFR1, TWIST1
3mammary gland bud formationGO:006061510.5FGF10, FGFR2
4mesenchymal cell differentiation involved in lung developmentGO:006091510.5FGF10, FGFR2
5branch elongation involved in salivary gland morphogenesisGO:006066710.5FGF10, FGFR2
6fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.5FGF10, FGFR2
7mesenchymal cell differentiationGO:004876210.5FGFR1, FGFR2
8mammary gland specificationGO:006059410.5FGF10, GLI3
9lacrimal gland developmentGO:003280810.4FGF10, FGFR2
10regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:006066510.4FGF10, FGFR1
11epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4FGF10, FGFR2
12bud elongation involved in lung branchingGO:006044910.4FGF10, FGFR2
13ventricular zone neuroblast divisionGO:002184710.3FGFR1, FGFR2
14epidermis morphogenesisGO:004873010.3FGF10, FGFR2
15otic vesicle formationGO:003091610.3FGF10, FGFR2
16organ inductionGO:000175910.3FGF10, FGFR1
17limb bud formationGO:006017410.3FGF10, FGFR2
18salivary gland morphogenesisGO:000743510.3FGF10, FGFR1
19embryonic digestive tract developmentGO:004856610.2FGF10, GLI3
20organ growthGO:003526510.2FGF10, FGFR2
21embryonic digestive tract morphogenesisGO:004855710.1FGF10, FGFR2, GLI3
22frontal suture morphogenesisGO:006036410.0GLI3, MSX2
23positive regulation of phospholipase activityGO:001051810.0FGFR1, FGFR2, FGFR3
24outflow tract septum morphogenesisGO:000314810.0FGFR2, MSX2
25lung-associated mesenchyme developmentGO:006048410.0FGFR1, FGFR2
26cranial suture morphogenesisGO:006036310.0MSX2, TWIST1
27orbitofrontal cortex developmentGO:00217699.9FGFR1, FGFR2
28branching involved in salivary gland morphogenesisGO:00604459.9FGF10, FGFR1, FGFR2
29negative regulation of cell differentiationGO:00455969.8FGF10, GLI3, TWIST1
30endochondral bone growthGO:00034169.7FGFR3, MSX2
31in utero embryonic developmentGO:00017019.7FGFR1, FGFR2, GLI3, TWIST1
32positive regulation of epithelial cell proliferationGO:00506799.7FGF10, FGFR2, TWIST1
33inner ear morphogenesisGO:00424729.7FGF10, FGFR1, FGFR2
34phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.7FGF10, FGFR1, FGFR2, FGFR3
35phosphatidylinositol phosphorylationGO:00468549.6FGF10, FGFR1, FGFR2, FGFR3
36regulation of phosphatidylinositol 3-kinase signalingGO:00140669.6FGF10, FGFR1, FGFR2, FGFR3
37odontogenesisGO:00424769.6FGFR2, MSX2, TWIST1
38phosphatidylinositol-mediated signalingGO:00480159.5FGF10, FGFR1, FGFR2, FGFR3
39fibroblast growth factor receptor signaling pathwayGO:00085439.5FGF10, FGFR1, FGFR2, FGFR3
40embryonic digit morphogenesisGO:00427339.5GLI3, MSX2, TWIST1
41lung developmentGO:00303249.5FGF10, FGFR1, FGFR2, GLI3
42peptidyl-tyrosine phosphorylationGO:00181089.5FGF10, FGFR1, FGFR2, FGFR3
43positive regulation of MAPK cascadeGO:00434109.4FGF10, FGFR1, FGFR2, FGFR3
44bone morphogenesisGO:00603499.3FGFR2, FGFR3, MSX2
45neuron migrationGO:00017649.2FGF13, FGFR1, TWIST1
46cell-cell signalingGO:00072679.1FGF10, FGF13, FGFR2, FGFR3
47embryonic limb morphogenesisGO:00303269.0FGFR1, GLI3, MSX2, TWIST1
48MAPK cascadeGO:00001658.8FGF10, FGF13, FGFR1, FGFR2, FGFR3
49wound healingGO:00420608.6FGF10, GLI3, MSX2
50negative regulation of transcription from RNA polymerase II promoterGO:00001228.3FGFR1, FGFR2, GLI3, MSX2, TWIST1

Molecular functions related to Acrocephalosyndactylia according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.3FGFR1, FGFR2, FGFR3
2fibroblast growth factor bindingGO:001713410.1FGFR1, FGFR2, FGFR3
3heparin bindingGO:000820110.0FGF10, FGFR1, FGFR2
41-phosphatidylinositol-3-kinase activityGO:00163039.7FGF10, FGFR1, FGFR2, FGFR3
5phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.7FGF10, FGFR1, FGFR2, FGFR3
6protein tyrosine kinase activityGO:00047139.6FGF10, FGFR1, FGFR2, FGFR3
7Ras guanyl-nucleotide exchange factor activityGO:00050889.6FGF10, FGFR1, FGFR2, FGFR3
8protein bindingGO:00055155.5ARID1B, FGF10, FGF13, FGFR1, FGFR2, FGFR3

Sources for Acrocephalosyndactylia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet