MCID: ACR005
MIFTS: 34

Acrodermatitis malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Acrodermatitis

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Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 10 45 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:2722
MeSH36 D000169
SNOMED-CT59 8197001
NCIt42 C84532

Summaries for Acrodermatitis

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Wikipedia:68 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

MalaCards based summary: Acrodermatitis is related to acrodermatitis enteropathica and enteropathica. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4). Affiliated tissues include skin, breast and liver, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:10 A dermatitis that selectively affects the hands and feet.

Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica31.9ALB, OTC, SLC39A4
2enteropathica11.2
3acrodermatitis chronica atrophicans10.9
4hepatitis10.5
5hepatitis b10.5
6cystic fibrosis10.4
7gianotti crosti syndrome10.4
8dermatitis10.3
9psoriasis10.3
10lyme disease10.3
11neuropathy10.3
12pustular psoriasis10.3
13anorexia nervosa10.3
14arthritis10.3
15acrodermatitis continua suppurativa of hallopeau10.3
16diarrhea10.2
17peripheral neuropathy10.2
18capillary hemangioma10.1ALB, IL36RN
19diverticulitis of colon10.1ALB, OTC
20psoriasis 14, pustular10.1
21celiac disease10.1
22ornithine transcarbamylase deficiency10.1
23acute lymphocytic leukemia10.1
24crohn's disease10.1
25leukemia10.1
26lactose intolerance10.1
27atopic dermatitis10.1
28nephrotic syndrome10.1
29pancreatitis10.1
30syndactyly10.1
31pustulosis palmaris et plantaris10.1
32erythema multiforme10.1ALB, CXCL10
33enteropathy-associated t-cell lymphoma10.0ALB, OTC, SLC39A4
34mandibular cancer10.0ALB, CD40LG
35fowler's syndrome10.0ALB, CD40LG
36typhoid fever10.0ALB, CD40LG
37vascular skin disease10.0ALB, CD40LG
38disease of mental health10.0ALB, CD40LG
39central nervous system chondroma10.0ALB, CD40LG
40hypersensitivity reaction type iv disease10.0ALB, CD40LG
41lemierre's syndrome10.0ALB, CD40LG
42transient cerebral ischemia10.0ALB, CD40LG
43hemorrhagic proctocolitis10.0ALB, CD40LG
44cutis laxa10.0ALB, CD40LG
45dysgammaglobulinemia10.0ALB, CD40LG
46autoimmune polyendocrine syndrome10.0ALB, CD40LG
47idiopathic progressive polyneuropathy10.0ALB, CD40LG
48peripheral nervous system neoplasm10.0ALB, CD40LG
49gum cancer10.0ALB, CD40LG
50glucocorticoid-induced osteoporosis10.0CD40LG, EPHA5

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms for Acrodermatitis

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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxycyclineapproved, investigational204564-25-054671203, 5281011
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Adoxa
Alodox
Alti-Doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Doryx
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy 100
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline
Doxycycline (200mg/day) or Placebo
Doxycycline (INN)
 
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline hydrochloride
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
Morgidox
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Ocudox
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Monohydrate
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laboratory Characteristics in Chronic Atrophic AcrodermatitisRecruitingNCT02147262
2Borrelia Species in Cutaneous Lyme BorreliosisRecruitingNCT00576082

Search NIH Clinical Center for Acrodermatitis


Cochrane evidence based reviews: Acrodermatitis

Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

33
Skin, Breast, Liver, Bone, T cells, Lymph node, Pancreas

Animal Models for Acrodermatitis or affiliated genes

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MGI Mouse Phenotypes related to Acrodermatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3ALB, CD40LG, CXCL10, IL36RN, OTC, SLC39A4
2MP:00107687.2ALB, CD40LG, CXCL10, IL36RN, OTC, SLC39A4

Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. (26560053)
2015
2
Ferdinando Gianotti and the papular acrodermatitis of childhood: a scientist against all the odds. (24827010)
2014
3
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
4
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
5
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
6
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
7
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
8
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. (17599860)
2007
9
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. (17483098)
2007
10
Acrodermatitis enteropathica-like dermatosis associated with ornithine transcarbamylase deficiency. (17845164)
2007
11
Etanercept and recalcitrant acrodermatitis continua of Hallopeau. (16991229)
2006
12
Nutritional zinc deficiency mimicking acrodermatitis enteropathica in a fully breast-fed infant. (17062090)
2006
13
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? (12705767)
2003
14
Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (11254458)
2001
15
Diagnosis: acrodermatitis continua of Hallopeau. (11294139)
2001
16
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis. (9687549)
1998
17
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
18
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. (7778918)
1995
19
An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. (8186509)
1994
20
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. (7908489)
1994
21
Lyme borreliosis presenting as acrodermatitis chronica atrophicans. (1579190)
1992
22
Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (1986705)
1991
23
Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. (3056202)
1988
24
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
25
Natural history of infantile papular acrodermatitis (Gianotti's disease) with HBsAg subtype adw. (3236828)
1988
26
Childhood acquired immune deficiency syndrome manifesting as acrodermatitis enteropathica. (2936876)
1986
27
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
28
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
29
The effects of diet and zinc treatment on the fatty acid composition of serum lipids and adipose tissue and on serum lipoproteins in two adolescent patients with acrodermatitis enteropathica. (6624693)
1983
30
Detection of hepatitis B surface antigen subtype adr in an epidemic of papular acrodermatitis of childhood (Gianotti's disease). (6459711)
1981
31
Percutaneous absorption of zinc in acrodermatitis enteropathica. (7333397)
1981
32
Acrodermatitis enteropathica, immunodeficiency, and zinc. (630912)
1978
33
Zinc therapy of acrodermatitis enteropathica. (659045)
1978
34
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
35
Zinc deficiency with skin lesions as seen in acrodermatitis enteropathica, and intoxication with zinc during parenteral nutrition. (416361)
1977
36
Animal model of human disease. Acrodermatitis enteropathica, zinc malabsorption. (559415)
1977
37
Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies. (196972)
1977
38
Letter: Plasma-zinc in acrodermatitis enteropathica. (55755)
1976
39
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
40
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
41
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
42
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
43
Determination of oxyquinoline concentrations in plasma in a patient treated for acrodermatitis enteropathica--an aid in therapeutic control. (4426461)
1974
44
Letter: Hepatitis B antigen in papular acrodermatitis in children. (4843656)
1974
45
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
46
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
47
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
48
Zinc deficiency in acrodermatitis enteropathica: multiple dietary intolerance treated with synthetic diet. (4577330)
1973
49
Acrodermatitis enteropathica with lactose intolerance. (5085934)
1972
50
Acrodermatitis enteropathica. (4918455)
1969

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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GO Terms for genes affiliated with Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.8CD40LG, CXCL10, EPHA5
2extracellular spaceGO:00056158.2ALB, CD40LG, CXCL10, IL36RN

Sources for Acrodermatitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet