MCID: ACR005
MIFTS: 36

Acrodermatitis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 12 50 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2722
MeSH 42 D000169
NCIt 47 C84532
SNOMED-CT 64 8197001
UMLS 69 C0001197

Summaries for Acrodermatitis

Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to acrodermatitis enteropathica and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Zinc and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 71 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

Related Diseases for Acrodermatitis

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 acrodermatitis enteropathica 12.4
2 acrodermatitis chronica atrophicans 12.3
3 acrodermatitis continua suppurativa of hallopeau 11.9
4 gianotti crosti syndrome 11.5
5 psoriasis 14, pustular 11.4
6 enteropathica 10.8
7 zinc deficiency, transient neonatal 10.8
8 psoriasis susceptibility 1 10.8
9 pustulosis of palm and sole 10.8
10 chronic gonococcal salpingitis 10.2 ALB IL36RN
11 bile duct adenocarcinoma 10.2 ALB CD40LG
12 colloid adenoma 10.2 ALB CD40LG
13 estrogen excess 10.2 ALB CD40LG
14 freiberg's disease 10.2 ALB CD40LG
15 striatonigral degeneration 10.2 ALB CD40LG
16 inner ear disease 10.2 ALB CD40LG
17 coronary artery dissection, spontaneous 10.2 ALB CD40LG
18 chronic inflammatory demyelinating polyneuritis 10.2 ALB CD40LG
19 angiokeratoma 10.2 ALB CD40LG
20 vulvar sarcoma 10.2 ALB CD40LG
21 venezuelan equine encephalitis 10.2 ALB CD40LG
22 dermatomycosis 10.1 ALB CD40LG
23 bladder diverticulum 10.1 ALB CD40LG
24 generalized dystonia 10.1 ALB CD40LG
25 fallopian tube serous adenocarcinoma 10.1 ALB CXCL10
26 hereditary alpha tryptasemia syndrome 10.1 ALB CD40LG
27 spastic entropion 10.1 ALB CD40LG
28 autonomic peripheral neuropathy 10.1 ALB CD40LG
29 benign deep fibrous histiocytoma 10.1 ALB CD40LG
30 plummer's disease 10.1 ALB CD40LG
31 amyotrohpic lateral sclerosis type 22 10.1 CD40LG CXCL10
32 oropharyngeal anthrax 10.1 CD40LG CXCL10
33 early yaws 10.1 ALB CD40LG
34 pseudohypoaldosteronism, type iic 10.1 CD40LG CXCL10
35 dysplastic nevus syndrome 10.1 CD40LG CXCL10
36 temtamy syndrome 10.1 CD40LG CXCL10
37 choreatic disease 10.1 ALB CD40LG
38 drug psychosis 10.1 CD40LG CXCL10
39 radial hypoplasia, triphalangeal thumbs and hypospadias 10.1 CD40LG IL36RN
40 benjamin syndrome 10.1 CD40LG CXCL10
41 depressed scar 10.1 ALB CD40LG
42 acute cholangitis 10.1 ALB CD40LG
43 mixed germ cell-sex cord neoplasm 10.1 ALB CD40LG
44 lacrimal gland carcinoma 10.1 CD40LG CXCL10
45 anterior foramen magnum meningioma 10.1 ALB CD40LG
46 hepatitis 10.1
47 proximal symphalangism 10.1 CD40LG CXCL10
48 hyperimmunoglobulin syndrome 10.1 CD40LG CXCL10
49 uterine ligament serous adenocarcinoma 10.1 ALB CD40LG
50 familial renal papillary carcinoma 10.0 ALB CD40LG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

MGI Mouse Phenotypes related to Acrodermatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 ALB CD40LG OTC PLIN2 SLC39A4
2 homeostasis/metabolism MP:0005376 9.5 ALB CD40LG CXCL10 IL36RN OTC PLIN2
3 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4

Drugs & Therapeutics for Acrodermatitis

Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved 7440-66-6 32051 23994
2
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
3 Anti-Bacterial Agents
4 Anti-Infective Agents
5 Antimalarials
6 Antiparasitic Agents
7 Antiprotozoal Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
2 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262
3 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

Anatomical Context for Acrodermatitis

MalaCards organs/tissues related to Acrodermatitis:

39
Skin, Breast, Liver, T Cells, Bone, Kidney, Pancreas

Publications for Acrodermatitis

Articles related to Acrodermatitis:

(show top 50) (show all 601)
id Title Authors Year
1
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
2
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
3
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
4
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
5
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
6
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
7
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
8
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. ( 27567652 )
2016
9
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
10
Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. ( 26684640 )
2016
11
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. ( 27818388 )
2016
12
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
13
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
14
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. ( 28329567 )
2016
15
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. ( 26781226 )
2016
16
Acrodermatitis Chronica Atrophicans. ( 26687575 )
2016
17
Pustules of the fingers: acrodermatitis continua. ( 27026671 )
2016
18
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2016
19
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
20
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. ( 27222886 )
2016
21
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
22
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
23
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
24
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. ( 26856809 )
2016
25
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
26
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
27
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. ( 27683154 )
2016
28
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. ( 27334242 )
2016
29
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. ( 26560053 )
2015
30
Acrodermatitis enteropathica in an adult. ( 26244999 )
2015
31
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. ( 25933075 )
2015
32
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. ( 25468189 )
2015
33
Acrodermatitis Dysmetabolica - Report of Two Cases. ( 25680786 )
2015
34
Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature. ( 26367710 )
2015
35
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. ( 25780817 )
2015
36
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. ( 26465901 )
2015
37
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. ( 26513074 )
2015
38
Acrodermatitis enteropathica in an infant with normal zinc levels. ( 25566908 )
2015
39
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. ( 26513075 )
2015
40
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. ( 25471551 )
2015
41
Histopathology and immunophenotype of acrodermatitis chronica atrophicans correlated with ospA and ospC genotypes of Borrelia species. ( 26156537 )
2015
42
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). ( 26051055 )
2015
43
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. ( 26443269 )
2015
44
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. ( 26351177 )
2015
45
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. ( 24850624 )
2014
46
Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. ( 25147643 )
2014
47
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. ( 24783119 )
2014
48
Acrodermatitis chronica atrophicans of the face: a case report and a brief review of the literature. ( 25230062 )
2014
49
Acrodermatitis continua of Hallopeau (ACH): Two cases successfully treated with adalimumab. ( 24215490 )
2014
50
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. ( 24962159 )
2014

Variations for Acrodermatitis

Expression for Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for Acrodermatitis

GO Terms for Acrodermatitis

Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ALB CD40LG CXCL10 IL36RN PLIN2

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.13 CD40LG CXCL10 IL36RN
2 inflammatory response GO:0006954 8.8 CD40LG CXCL10 IL36RN

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CD40LG CXCL10 IL36RN

Sources for Acrodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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