MCID: ACR005
MIFTS: 36

Acrodermatitis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

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Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 11 48 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2722
MeSH39 D000169
SNOMED-CT62 8197001
NCIt45 C84532

Summaries for Acrodermatitis

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Wikipedia:71 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively... more...

MalaCards based summary: Acrodermatitis is related to acrodermatitis enteropathica and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). Affiliated tissues include skin, breast and liver, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Disease Ontology:11 A dermatitis that selectively affects the hands and feet.

Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica12.4
2acrodermatitis chronica atrophicans12.3
3acrodermatitis continua suppurativa of hallopeau11.9
4gianotti crosti syndrome11.5
5psoriasis 14, pustular11.4
6enteropathica10.8
7zinc deficiency, transient neonatal10.8
8psoriasis susceptibility 110.8
9pustulosis of palm and sole10.8
10chronic gonococcal salpingitis10.2ALB, IL36RN
11bile duct adenocarcinoma10.2ALB, CD40LG
12colloid adenoma10.2ALB, CD40LG
13estrogen excess10.2ALB, CD40LG
14freiberg's disease10.2ALB, CD40LG
15striatonigral degeneration10.2ALB, CD40LG
16inner ear disease10.2ALB, CD40LG
17coronary artery dissection, spontaneous10.2ALB, CD40LG
18chronic inflammatory demyelinating polyneuritis10.2ALB, CD40LG
19angiokeratoma10.2ALB, CD40LG
20vulvar sarcoma10.2ALB, CD40LG
21venezuelan equine encephalitis10.2ALB, CD40LG
22dermatomycosis10.1ALB, CD40LG
23bladder diverticulum10.1ALB, CD40LG
24generalized dystonia10.1ALB, CD40LG
25fallopian tube serous adenocarcinoma10.1ALB, CXCL10
26hereditary alpha tryptasemia syndrome10.1ALB, CD40LG
27spastic entropion10.1ALB, CD40LG
28autonomic peripheral neuropathy10.1ALB, CD40LG
29benign deep fibrous histiocytoma10.1ALB, CD40LG
30plummer's disease10.1ALB, CD40LG
31amyotrohpic lateral sclerosis type 2210.1CD40LG, CXCL10
32oropharyngeal anthrax10.1CD40LG, CXCL10
33early yaws10.1ALB, CD40LG
34pseudohypoaldosteronism, type iic10.1CD40LG, CXCL10
35dysplastic nevus syndrome10.1CD40LG, CXCL10
36temtamy syndrome10.1CD40LG, CXCL10
37choreatic disease10.1ALB, CD40LG
38drug psychosis10.1CD40LG, CXCL10
39radial hypoplasia, triphalangeal thumbs and hypospadias10.1CD40LG, IL36RN
40benjamin syndrome10.1CD40LG, CXCL10
41depressed scar10.1ALB, CD40LG
42acute cholangitis10.1ALB, CD40LG
43mixed germ cell-sex cord neoplasm10.1ALB, CD40LG
44lacrimal gland carcinoma10.1CD40LG, CXCL10
45anterior foramen magnum meningioma10.1ALB, CD40LG
46hepatitis10.1
47proximal symphalangism10.1CD40LG, CXCL10
48hyperimmunoglobulin syndrome10.1CD40LG, CXCL10
49uterine ligament serous adenocarcinoma10.1ALB, CD40LG
50familial renal papillary carcinoma10.0ALB, CD40LG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4ALB, CD40LG, OTC, PLIN2, SLC39A4
2MP:00053708.1ALB, OTC, PLIN2, SLC39A4
3MP:00053767.5ALB, CD40LG, CXCL10, IL36RN, OTC, PLIN2

Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Zincapproved22967440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Doxycyclineapproved, investigational, vet_approved243564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
5-hydroxy-α-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Anhydrous doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
 
Doxycycline (INN)
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
3Antiparasitic Agents2199
4Antiprotozoal Agents2051
5Antimalarials1246
6Anti-Bacterial Agents11226
7Anti-Infective Agents22062

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Study of Severe Zinc DeficienciesCompletedNCT02870166
2Laboratory Characteristics in Chronic Atrophic AcrodermatitisRecruitingNCT02147262
3Borrelia Species in Cutaneous Lyme BorreliosisRecruitingNCT00576082

Search NIH Clinical Center for Acrodermatitis


Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

36
Skin, Breast, Liver, Pancreas, T cells, Kidney, Bone

Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. (28056538)
2017
2
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. (28017623)
2017
3
Acrodermatitis caused by nutritional deficiency and metabolic disorders. (27938814)
2017
4
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. (28340843)
2017
5
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. (28521835)
2017
6
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. (28188634)
2017
7
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. (27940220)
2016
8
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. (27567652)
2016
9
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. (26955145)
2016
10
Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. (26684640)
2016
11
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. (27818388)
2016
12
Acrodermatitis enteropathica in a pair of twins. (28435477)
2016
13
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. (26916651)
2016
14
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. (28329567)
2016
15
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. (26781226)
2016
16
Acrodermatitis Chronica Atrophicans. (26687575)
2016
17
Pustules of the fingers: acrodermatitis continua. (27026671)
2016
18
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. (27231138)
2016
19
Acrodermatitis Enteropathica: A Case Report. (27196457)
2016
20
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. (27222886)
2016
21
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. (27502263)
2016
22
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. (27904292)
2016
23
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. (26920763)
2016
24
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. (26856809)
2016
25
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. (26661624)
2016
26
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. (27335369)
2016
27
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. (27683154)
2016
28
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. (27334242)
2016
29
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. (26560053)
2015
30
Acrodermatitis enteropathica in an adult. (26244999)
2015
31
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. (25933075)
2015
32
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. (25468189)
2015
33
Acrodermatitis Dysmetabolica - Report of Two Cases. (25680786)
2015
34
Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature. (26367710)
2015
35
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. (25780817)
2015
36
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. (26465901)
2015
37
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. (26513074)
2015
38
Acrodermatitis enteropathica in an infant with normal zinc levels. (25566908)
2015
39
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. (26513075)
2015
40
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. (25471551)
2015
41
Histopathology and immunophenotype of acrodermatitis chronica atrophicans correlated with ospA and ospC genotypes of Borrelia species. (26156537)
2015
42
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). (26051055)
2015
43
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. (26443269)
2015
44
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. (26351177)
2015
45
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. (24850624)
2014
46
Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. (25147643)
2014
47
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. (24783119)
2014
48
Acrodermatitis chronica atrophicans of the face: a case report and a brief review of the literature. (25230062)
2014
49
Acrodermatitis continua of Hallopeau (ACH): Two cases successfully treated with adalimumab. (24215490)
2014
50
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. (24962159)
2014

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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GO Terms for genes affiliated with Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7ALB, CD40LG, CXCL10, IL36RN, PLIN2

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069559.7CD40LG, CXCL10, IL36RN
2inflammatory responseGO:00069549.1CD40LG, CXCL10, IL36RN

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1CD40LG, CXCL10, IL36RN

Sources for Acrodermatitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet