MCID: ACR005
MIFTS: 47

Acrodermatitis malady

Rare diseases, Skin diseases categories

Summaries for Acrodermatitis

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Wikipedia:63 Acrodermatitis /ac more...

MalaCards based summary: Acrodermatitis is related to acrodermatitis enteropathica and hepatitis. An important gene associated with Acrodermatitis is SLC39A4 (solute carrier family 39 (zinc transporter), member 4), and among its related pathways are Inflammatory Response Pathway and Cellular roles of Anthrax toxin. The compounds gamma globulin and auranofin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Acrodermatitis

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Acrodermatitis, Aliases & Descriptions:

Name: Acrodermatitis 9 41 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:2722
NCIt38 C84532
SNOMED-CT55 8197001
MeSH33 D000169

Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica31.9SLC39A1, SLC30A4, SLC39A5, SLC39A4, SLC30A5
2hepatitis30.8CXCL10, OTC, CD40LG
3arthritis30.5IL1B, TNF
4hepatitis b30.3ALB, IFNG, CXCL10
5dermatitis30.2IFNG, CXCL10, CXCL9
6psoriatic arthritis30.0TNF, IL1B
7arthropathy29.8TNF, CXCL10, IL1B
8psoriasis29.5TNF, CXCL10, CXCL9, IFNG, IL1B
9atopic dermatitis29.4CXCL9, IFNG, TNF, CXCL10
10leukemia29.3TNF, OTC, IFNG, CD40LG, IL1B
11colitis29.3IL1B, IFNG, CXCL10, TNF
12ulcerative colitis29.2CXCL10, IFNG, IL1B, TNF
13enteropathica11.2
14hemorrhagic fever10.5CD40LG
15schnitzler syndrome10.5CD40LG
16hepatorenal syndrome10.5ALB
17cystic fibrosis10.4
18gianotti crosti syndrome10.4
19intervertebral disc disease10.4IL1B
20pleurisy10.3IL1B
21acute liver failure10.3ALB, OTC
22brain edema10.3ALB, OTC
23alopecia areata10.3IFNG
24neuropathy10.3
25biliary atresia10.2CXCL10, OTC
26lyme disease10.2
27acrodermatitis continua suppurativa of hallopeau10.2
28alcoholic hepatitis10.2ALB, TNF
29paracoccidioidomycosis10.2CXCL10, CXCL9
30allergic contact dermatitis10.2CXCL9, CXCL10
31anorexia nervosa10.2
32diarrhea10.2
33peripheral neuropathy10.2
34mastitis10.2ALB, IL1B
35blau syndrome10.1IL1B, TNF
36brain disease10.1OTC, ALB, CXCL10
37aids dementia complex10.1IL1B, TNF
38familial mediterranean fever, ar10.1IL1B, TNF
39chorioamnionitis10.1TNF, IL1B
40connective tissue disease10.1CD40LG, ALB, TNF
41vasculitis10.1ALB, CD40LG, TNF
42leishmaniasis10.1IFNG
43vascular disease10.1TNF, IL1B
44ornithine transcarbamylase deficiency10.1
45crohn's disease10.1
46lactose intolerance10.1
47nephrotic syndrome10.1
48pancreatitis10.1
49interstitial lung disease10.1TNF, IL1B
50chronic granulomatous disease10.0OTC, IFNG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms for Acrodermatitis

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Drugs & Therapeutics for Acrodermatitis

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Drug clinical trials:

Search ClinicalTrials for Acrodermatitis

Search NIH Clinical Center for Acrodermatitis

Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

31
Skin, Breast, Liver, Eye, Bone, Lymph node, Colon, Pancreas, T cells

Animal Models for Acrodermatitis or affiliated genes

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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Ferdinando Gianotti and the papular acrodermatitis of childhood: a scientist against all the odds. (24827010)
2014
2
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
3
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
4
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
5
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
6
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
7
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. (17599860)
2007
8
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. (17483098)
2007
9
Acrodermatitis enteropathica-like dermatosis associated with ornithine transcarbamylase deficiency. (17845164)
2007
10
Etanercept and recalcitrant acrodermatitis continua of Hallopeau. (16991229)
2006
11
Nutritional zinc deficiency mimicking acrodermatitis enteropathica in a fully breast-fed infant. (17062090)
2006
12
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? (12705767)
2003
13
Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (11254458)
2001
14
Diagnosis: acrodermatitis continua of Hallopeau. (11294139)
2001
15
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis. (9687549)
1998
16
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
17
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. (7778918)
1995
18
An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. (8186509)
1994
19
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. (7908489)
1994
20
Lyme borreliosis presenting as acrodermatitis chronica atrophicans. (1579190)
1992
21
Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (1986705)
1991
22
Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. (3056202)
1988
23
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
24
Natural history of infantile papular acrodermatitis (Gianotti's disease) with HBsAg subtype adw. (3236828)
1988
25
Childhood acquired immune deficiency syndrome manifesting as acrodermatitis enteropathica. (2936876)
1986
26
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
27
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
28
The effects of diet and zinc treatment on the fatty acid composition of serum lipids and adipose tissue and on serum lipoproteins in two adolescent patients with acrodermatitis enteropathica. (6624693)
1983
29
Detection of hepatitis B surface antigen subtype adr in an epidemic of papular acrodermatitis of childhood (Gianotti's disease). (6459711)
1981
30
Percutaneous absorption of zinc in acrodermatitis enteropathica. (7333397)
1981
31
Acrodermatitis enteropathica, immunodeficiency, and zinc. (630912)
1978
32
Zinc therapy of acrodermatitis enteropathica. (659045)
1978
33
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
34
Zinc deficiency with skin lesions as seen in acrodermatitis enteropathica, and intoxication with zinc during parenteral nutrition. (416361)
1977
35
Animal model of human disease. Acrodermatitis enteropathica, zinc malabsorption. (559415)
1977
36
Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies. (196972)
1977
37
Letter: Plasma-zinc in acrodermatitis enteropathica. (55755)
1976
38
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
39
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
40
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
41
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
42
Determination of oxyquinoline concentrations in plasma in a patient treated for acrodermatitis enteropathica--an aid in therapeutic control. (4426461)
1974
43
Letter: Hepatitis B antigen in papular acrodermatitis in children. (4843656)
1974
44
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
45
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
46
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
47
Zinc deficiency in acrodermatitis enteropathica: multiple dietary intolerance treated with synthetic diet. (4577330)
1973
48
Acrodermatitis enteropathica with lactose intolerance. (5085934)
1972
49
Acrodermatitis enteropathica. (4918455)
1969
50
Acrodermatitis enteropathica. (4229461)
1967

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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Pathways related to Acrodermatitis according to GeneCards Suite gene sharing:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD40LG, IFNG
29.6TNF, IL1B
39.6TNF, IL1B
4
Show member pathways
Serotonin Transporter Activity36
9.6TNF, IL1B
59.6IL1B, TNF
69.6IFNG, TNF
7
Show member pathways
9.6IFNG, TNF
8
Show member pathways
9.6IFNG, TNF
99.6CXCL9, CXCL10
109.4TNF, IL1B, CD40LG
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.3CD40LG, IFNG, TNF
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.3TNF, IL36RN, IL1B
139.3IL1B, CXCL10, TNF
149.2TNF, IFNG, IL1B
159.2TNF, IFNG, IL1B
169.2TNF, IFNG, IL1B
179.2TNF, IFNG, IL1B
189.2TNF, IFNG, IL1B
199.2IL1B, IFNG, TNF
209.2IL1B, IFNG, TNF
21
Show member pathways
9.2IL1B, IFNG, TNF
22
Show member pathways
Immune response MIF in innate immunity response58
9.2IL1B, IFNG, TNF
239.2IL1B, IFNG, TNF
249.2IL1B, IFNG, TNF
25
Show member pathways
IL27-mediated signaling events36
9.2IL1B, IFNG, TNF
26
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.0CD40LG, IL1B, IFNG, TNF
27
Show member pathways
9.0TNF, IFNG, IL1B, CD40LG
289.0TNF, IFNG, IL1B, CD40LG
29
Show member pathways
9.0TNF, IFNG, IL1B, CD40LG
30
Show member pathways
thioredoxin pathway36
8.9TNF, IFNG, IL1B, ALB
31
Show member pathways
8.9SLC30A5, SLC39A4, SLC39A1, SLC39A5
328.9IL1B, IFNG, CXCL10, TNF
33
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.9IL1B, IFNG, CXCL10, TNF
34
Show member pathways
8.9IL1B, IFNG, CXCL10, TNF
358.8CXCL10, CXCL9, IFNG, IL1B
36
Show member pathways
8.8TNF, CXCL10, CXCL9, IL1B
37
Show member pathways
8.8TNF, CXCL10, CXCL9, IL1B
38
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.7TNF, CXCL9, IFNG, IL1B
398.6IFNG, IL1B, SLC39A1, SLC39A4
40
Show member pathways
8.6SLC30A5, SLC39A4, SLC39A1, SLC39A5, ALB
41
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.4IL1B, IFNG, CXCL9, CXCL10, TNF
42
Show member pathways
8.1TNF, CXCL10, CXCL9, IFNG, IL1B, CD40LG

Compounds for genes affiliated with Acrodermatitis

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Compounds related to Acrodermatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1gamma globulin439.9ALB, CD40LG, IFNG
2auranofin28 43 59 1212.8IFNG, ALB, IL1B
3aminoguanidine43 28 1211.8ALB, IL1B, IFNG
4okt3439.6CD40LG, TNF, IFNG
5vesnarinone439.6TNF, IL1B, IFNG
6taurine chloramine439.6IL1B, IFNG, TNF
7gold sodium thiomalate439.6IL1B, TNF, IFNG
8sulfasalazine28 43 49 1212.6CD40LG, IL1B, TNF
9staurosporin439.6IL1B, IFNG, TNF
10polymyxin b439.6IL1B, IFNG, TNF
11triptolide439.5IFNG, TNF, IL1B
12gm-csf43 2810.5IFNG, TNF, IL1B
13budesonide43 49 1211.5IL1B, IFNG, TNF
14ribavirin43 49 1211.5CXCL10, IFNG, CD40LG
152,5-oligoadenylate439.5TNF, CXCL10, IFNG
16mycophenolate mofetil43 49 1211.4TNF, IFNG, ALB, CD40LG
17allergens439.4CXCL10, IFNG, CD40LG
18il-12439.4IL1B, IFNG, CD40LG, TNF
19etanercept43 49 1211.4IFNG, TNF, IL1B
20l-nmma439.3IFNG, TNF, IL1B
21thalidomide43 49 59 1212.3IFNG, TNF, CD40LG, IL1B
22fluticasone propionate43 49 59 1212.3CXCL10, IFNG, TNF, IL1B
23polyinosinic-polycytidylic acid439.3IL1B, TNF, CXCL10, IFNG
24poly(i-c)439.3IL1B, TNF, CXCL10, IFNG
25infliximab43 49 1211.3TNF, IL1B, IFNG, CXCL10
26ciglitazone43 2810.3TNF, IL1B, PLIN2
27herbimycin a43 5910.3TNF, IFNG, CD40LG, IL1B
28hydrocortisone43 2 59 1212.3CXCL10, IL1B, TNF, IFNG
29pentoxifylline43 1210.2IL1B, IFNG, TNF
30groalpha439.2CXCL9, IL1B, CXCL10, TNF
31tacrolimus43 49 1211.2CXCL10, TNF, ALB, IFNG
32tarc439.2CXCL9, CXCL10, TNF, IFNG
33calcitriol43 59 24 1212.1ALB, TNF, IL1B, IFNG
34ifn-alpha439.1CXCL10, IFNG, CXCL9
35ivig439.1ALB, CD40LG, IL1B, IFNG, TNF
36ionomycin439.1TNF, CXCL9, IFNG, CD40LG
37neopterin439.0CXCL10, TNF, CD40LG, IL1B, IFNG
38indomethacin43 28 59 1212.0ALB, IL1B, IFNG, TNF, CD40LG
39creatinine439.0OTC, CD40LG, ALB, CXCL9, CXCL10
40genistein43 28 59 2 24 1214.0CD40LG, IFNG, IL1B, CXCL10, TNF
4115-deoxy-delta-12,14-prostaglandin j2438.9IFNG, IL1B, TNF
42il 10438.8IL1B, IFNG, CXCL9, CXCL10, TNF
43ccl343 289.8TNF, CXCL10, CXCL9, IFNG, IL1B
44endotoxin438.5CD40LG, TNF, CXCL10, CXCL9, IFNG, IL1B
45rantes438.5IL1B, IFNG, CXCL9, CXCL10, TNF, CD40LG
46dexamethasone43 49 28 1211.5TNF, CXCL10, CD40LG, IL1B, IFNG, CXCL9
47nitric oxide43 24 1210.4OTC, IFNG, CXCL10, IL1B, TNF, CXCL9
48pge2438.4CD40LG, PLIN2, IL1B, IFNG, CXCL10, TNF
49histamine43 28 2410.2CXCL9, IFNG, IL1B, ALB, TNF, CD40LG
50vegf437.9CD40LG, TNF, CXCL10, CXCL9, IFNG, PLIN2

GO Terms for genes affiliated with Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.2TNF, CXCL10, CXCL9, IFNG, CD40LG
2extracellular regionGO:00055767.4ALB, PLIN2, IL1B, IFNG, CXCL9, CXCL10
3extracellular spaceGO:00056157.4CD40LG, TNF, CXCL10, CXCL9, IFNG, IL36RN

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cellular response to zinc ion starvationGO:003422410.4SLC39A4, SLC39A5
2cellular zinc ion homeostasisGO:000688210.3SLC39A4, SLC30A5
3zinc ion transportGO:000682910.3SLC39A5, SLC30A5
4response to zinc ionGO:001004310.1OTC, SLC30A5
5regulation of immunoglobulin secretionGO:005102310.1CD40LG, TNF
6positive regulation of interleukin-6 biosynthetic processGO:004541010.0IFNG, IL1B
7sequestering of triglycerideGO:003073010.0IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.0TNF, IL1B
9positive regulation of fever generationGO:003162210.0IL1B, TNF
10positive regulation of vitamin D biosynthetic processGO:006055710.0TNF, IFNG
11positive regulation of cAMP metabolic processGO:003081610.0CXCL10, CXCL9
12regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0TNF, IL1B
13negative regulation of lipid catabolic processGO:005099510.0IL1B, TNF
14negative regulation of interleukin-6 productionGO:00327159.9TNF, IL36RN
15positive regulation of interleukin-12 productionGO:00327359.9CD40LG, IFNG
16positive regulation of cAMP-mediated signalingGO:00439509.9CXCL9, CXCL10
17negative regulation of growth of symbiont in hostGO:00441309.9IFNG, TNF
18positive regulation of NF-kappaB import into nucleusGO:00423469.9TNF, IL1B
19positive regulation of osteoclast differentiationGO:00456729.9IFNG, TNF
20positive regulation of release of sequestered calcium ion into cytosolGO:00512819.8CXCL9, CXCL10
21protein import into nucleus, translocationGO:00000609.8TNF, IFNG
22lipopolysaccharide-mediated signaling pathwayGO:00316639.8TNF, IL1B
23positive regulation of mitosisGO:00458409.7TNF, IL1B
24positive regulation of calcidiol 1-monooxygenase activityGO:00605599.7IFNG, IL1B, TNF
25positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, IL1B, TNF
26protein kinase B signalingGO:00434919.6TNF, IL1B
27positive regulation of membrane protein ectodomain proteolysisGO:00510449.6TNF, IFNG, IL1B
28positive regulation of nitric oxide biosynthetic processGO:00454299.6IFNG, TNF, IL1B
29regulation of insulin secretionGO:00507969.6IL1B, TNF, IFNG
30negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.5TNF, IL1B
31defense response to virusGO:00516079.5CXCL9, CXCL10, IFNG
32cellular response to organic cyclic compoundGO:00714079.3TNF, IL1B
33zinc ion transmembrane transportGO:00715779.3SLC30A5, SLC30A4, SLC39A1
34cell-cell signalingGO:00072679.2CXCL9, CXCL10, IL1B
35response to drugGO:00424939.1TNF, IFNG, OTC, PLIN2
36transmembrane transportGO:00550859.0SLC39A4, SLC30A5, SLC39A1, ALB, SLC39A5
37inflammatory responseGO:00069548.9TNF, CD40LG, CXCL10, IL1B, CXCL9

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.7CD40LG, TNF
2CXCR3 chemokine receptor bindingGO:00482489.5CXCL9, CXCL10
3interleukin-1 receptor bindingGO:00051499.5IL1B, IL36RN
4zinc ion transmembrane transporter activityGO:00053858.7SLC30A5, SLC39A4, SLC30A4, SLC39A1
5cytokine activityGO:00051258.1TNF, CXCL9, IFNG, IL36RN, IL1B, CD40LG

Products for genes affiliated with Acrodermatitis

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Sources for Acrodermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet