MCID: ACR005
MIFTS: 37

Acrodermatitis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

About this section

Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 10 45 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:2722
MeSH36 D000169
SNOMED-CT59 8197001
NCIt42 C84532
UMLS65 C0001197

Summaries for Acrodermatitis

About this section
Wikipedia:68 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

MalaCards based summary: Acrodermatitis is related to dermatitis and acrodermatitis enteropathica. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). Affiliated tissues include breast, lung and skin, and related mouse phenotypes are liver/biliary system and integument.

Disease Ontology:10 A dermatitis that selectively affects the hands and feet.

Related Diseases for Acrodermatitis

About this section

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis27.1ALB, CD40LG, IL36RN, OTC, PLIN2, SLC39A4
2acrodermatitis enteropathica12.4
3acrodermatitis chronica atrophicans12.4
4acrodermatitis continua suppurativa of hallopeau12.0
5gianotti crosti syndrome11.7
6psoriasis 14, pustular11.2
7enteropathica10.9
8pustulosis of palm and sole10.9
9mixed malaria10.3ALB, CD40LG
10fowler's syndrome10.3ALB, CD40LG
11somatoform disorder10.3ALB, CD40LG
12black piedra10.3ALB, IL36RN
13weill-marchesani syndrome10.3ALB, CD40LG
14indolent myeloma10.3ALB, CD40LG
15splenic abscess10.3ALB, CD40LG
16subacute glomerulonephritis10.3ALB, CD40LG
17ileitis10.3ALB, CD40LG
18cerebellopontine angle primitive neuroectodermal10.3ALB, CD40LG
19angioedema10.3ALB, CD40LG
20arcus senilis10.3ALB, CD40LG
21peripheral artery disease10.3ALB, CD40LG
22vulvar melanoma10.2ALB, CD40LG
23autoimmune disease of blood10.2ALB, CD40LG
24cervix melanoma10.2ALB, CD40LG
25small intestinal vasoactive intestinal peptide producing tumor10.2ALB, CD40LG
26blastomycosis10.2ALB, CD40LG
27primary progressive multiple sclerosis10.2ALB, CD40LG
28suppurative cholangitis10.2ALB, CD40LG
29dentin dysplasia10.2ALB, CD40LG
30hepatitis10.2
31antiphospholipid syndrome10.2ALB, CD40LG
32commensal bacterial infectious disease10.2ALB, CD40LG
33hepatic cystic hamartoma10.2ALB, CD40LG
34cystic fibrosis10.2
35hepatitis b10.2
36fatty liver disease10.2ALB, CD40LG
37diffuse scleroderma10.1ALB, CD40LG
38uterine corpus epithelioid leiomyoma10.1ALB, CD40LG
39cll/sll10.1ALB, CD40LG
40congenital disorder of glycosylation, type ih10.1ALB, CD40LG
41optic nerve disease10.1ALB, CD40LG
42psoriasis10.1
43ossifying fibroma10.1ALB, CD40LG
44pustular psoriasis10.1
45pneumocystosis10.0ALB, CD40LG
46anorexia nervosa10.0
47neuropathy10.0
48mononeuritis of lower limb10.0ALB, CD40LG
49arthritis10.0
50lyme disease10.0

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms for Acrodermatitis

About this section

Drugs & Therapeutics for Acrodermatitis

About this section

Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxycyclineapproved, investigational219564-25-054671203, 5281011
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Adoxa
Alodox
Alti-Doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Doryx
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy 100
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline
Doxycycline (200mg/day) or Placebo
Doxycycline (INN)
 
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline hydrochloride
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
Morgidox
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Ocudox
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Monohydrate
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
2Antiprotozoal Agents1730
3Antiparasitic Agents1854
4Antimalarials1058
5Anti-Infective Agents17220
6Anti-Bacterial Agents9140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laboratory Characteristics in Chronic Atrophic AcrodermatitisRecruitingNCT02147262
2Borrelia Species in Cutaneous Lyme BorreliosisRecruitingNCT00576082

Search NIH Clinical Center for Acrodermatitis


Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

About this section

Anatomical Context for Acrodermatitis

About this section

MalaCards organs/tissues related to Acrodermatitis:

33
Breast, Lung, Skin, Heart, Liver, Thyroid, T cells

Animal Models for Acrodermatitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Acrodermatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3ALB, OTC, PLIN2, SLC39A4
2MP:00107718.2CD40LG, IL36RN, OTC, PLIN2
3MP:00053797.8ALB, CD40LG, OTC, PLIN2, SLC39A4
4MP:00053847.3ALB, CD40LG, OTC, PLIN2, SLC39A4
5MP:00053767.1ALB, CD40LG, IL36RN, OTC, PLIN2, SLC39A4

Publications for Acrodermatitis

About this section

Articles related to Acrodermatitis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. (26661624)
2016
2
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. (26560053)
2015
3
Ferdinando Gianotti and the papular acrodermatitis of childhood: a scientist against all the odds. (24827010)
2014
4
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
5
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
6
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
7
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
8
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
9
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. (17599860)
2007
10
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. (17483098)
2007
11
Acrodermatitis enteropathica-like dermatosis associated with ornithine transcarbamylase deficiency. (17845164)
2007
12
Etanercept and recalcitrant acrodermatitis continua of Hallopeau. (16991229)
2006
13
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? (12705767)
2003
14
Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (11254458)
2001
15
Diagnosis: acrodermatitis continua of Hallopeau. (11294139)
2001
16
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis. (9687549)
1998
17
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
18
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. (7778918)
1995
19
An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. (8186509)
1994
20
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. (7908489)
1994
21
Lyme borreliosis presenting as acrodermatitis chronica atrophicans. (1579190)
1992
22
Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (1986705)
1991
23
Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. (3056202)
1988
24
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
25
Natural history of infantile papular acrodermatitis (Gianotti's disease) with HBsAg subtype adw. (3236828)
1988
26
Childhood acquired immune deficiency syndrome manifesting as acrodermatitis enteropathica. (2936876)
1986
27
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
28
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
29
The effects of diet and zinc treatment on the fatty acid composition of serum lipids and adipose tissue and on serum lipoproteins in two adolescent patients with acrodermatitis enteropathica. (6624693)
1983
30
Detection of hepatitis B surface antigen subtype adr in an epidemic of papular acrodermatitis of childhood (Gianotti's disease). (6459711)
1981
31
Percutaneous absorption of zinc in acrodermatitis enteropathica. (7333397)
1981
32
Acrodermatitis enteropathica, immunodeficiency, and zinc. (630912)
1978
33
Zinc therapy of acrodermatitis enteropathica. (659045)
1978
34
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
35
Zinc deficiency with skin lesions as seen in acrodermatitis enteropathica, and intoxication with zinc during parenteral nutrition. (416361)
1977
36
Animal model of human disease. Acrodermatitis enteropathica, zinc malabsorption. (559415)
1977
37
Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies. (196972)
1977
38
Letter: Plasma-zinc in acrodermatitis enteropathica. (55755)
1976
39
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
40
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
41
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
42
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
43
Determination of oxyquinoline concentrations in plasma in a patient treated for acrodermatitis enteropathica--an aid in therapeutic control. (4426461)
1974
44
Letter: Hepatitis B antigen in papular acrodermatitis in children. (4843656)
1974
45
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
46
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
47
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
48
Zinc deficiency in acrodermatitis enteropathica: multiple dietary intolerance treated with synthetic diet. (4577330)
1973
49
Acrodermatitis enteropathica with lactose intolerance. (5085934)
1972
50
Acrodermatitis enteropathica. (4918455)
1969

Variations for Acrodermatitis

About this section

Expression for genes affiliated with Acrodermatitis

About this section
Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

About this section

GO Terms for genes affiliated with Acrodermatitis

About this section

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:00301689.4ALB, CD40LG

Sources for Acrodermatitis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet