MCID: ACR005
MIFTS: 45

Acrodermatitis malady

Summaries for Acrodermatitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

MalaCards: Acrodermatitis is related to acrodermatitis enteropathica and cystic fibrosis. An important gene associated with Acrodermatitis is SLC39A4 (solute carrier family 39 (zinc transporter), member 4), and among its related pathways are Senescence and Autophagy and Folate biosynthesis. The compounds amifostine and 7,8-dihydroneopterin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related mouse phenotypes are other and limbs/digits/tail.

Aliases & Classifications for Acrodermatitis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
See all sources

Aliases & Descriptions:

acrodermatitis 8 42 10 60


External Ids:

Disease Ontology8 DOID:2722
MeSH34 D000169
SNOMED-CT56 8197001
NCIt39 C84532

Related Diseases for Acrodermatitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica31.7SLC39A4, SLC30A5, SLC39A1, SLC39A5, SLC30A4
2cystic fibrosis30.5OTC
3diarrhea30.1ALPPL2, ALPP, ALPL
4pancreatitis30.0ALPL, ALPP, ALPPL2
5arthropathy29.8ALPL
6hepatitis10.4
7hepatitis b10.4
8dermatitis10.2
9neuropathy10.2
10psoriasis10.2
11lyme disease10.2
12anorexia nervosa10.2
13hepatitis a10.1
14arthritis10.1
15peripheral neuropathy10.1
16gianotti crosti syndrome10.1
17crohn's disease10.0
18maple syrup urine disease10.0
19lactose intolerance10.0
20acute leukemia10.0
21acute lymphocytic leukemia10.0
22leukemia10.0
23nephrotic syndrome10.0
24optic atrophy10.0
25squamous cell carcinoma10.0
26acrodermatitis continua suppurativa of hallopeau10.0
27schistosomiasis10.0CD40LG
28dysgerminoma10.0ALPP
29biliary atresia10.0OTC
30hypophosphatasia, infantile10.0ALPL, ALPP
31endodermal sinus tumor10.0ALPP, ALPPL2
32osteosclerosis10.0ALPL, ALPPL2, ALPP
33osteitis fibrosa10.0ALPL, ALPPL2, ALPP
34cholelithiasis10.0ALPPL2, ALPL, ALPP
35choledocholithiasis10.0ALPP, ALPPL2, ALPL
36hypophosphatasia10.0ALPP, ALPL, ALPPL2
37x-linked hypophosphatemia10.0ALPPL2, ALPL, ALPP
38bilirubin metabolic disorder10.0ALPL, ALPP, ALPPL2
39embryonal cancer10.0ALPP, ALPPL2, ALPL
40hyperphosphatemia10.0ALPL, ALPP, ALPPL2
41fibrous dysplasia10.0ALPL, ALPP, ALPPL2
42cholangitis10.0ALPP, ALPPL2, ALPL
43renal osteodystrophy10.0ALPL, ALPP, ALPPL2
44hypersensitivity reaction type ii disease10.0ALPPL2, ALPP, ALPL
45calcinosis10.0ALPP, ALPL, ALPPL2
46hypophosphatemia10.0ALPL, ALPPL2, ALPP
47cork-handlers' disease10.0ALPL, ALPP, ALPPL2
48vascular disease10.0ALPPL2, ALPP, ALPL
49osteomalacia10.0ALPL, ALPP, ALPPL2
50osteogenesis imperfecta10.0ALPL, ALPP, ALPPL2

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Clinical Features for Acrodermatitis

About this section

Drugs & Therapeutics for Acrodermatitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Acrodermatitis

Drug clinical trials:

Search ClinicalTrials for Acrodermatitis

Search NIH Clinical Center for Acrodermatitis

Search CenterWatch for Acrodermatitis

Genetic Tests for Acrodermatitis

About this section

Anatomical Context for Acrodermatitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Acrodermatitis:

32
Skin, Breast, Liver, Eye, Bone, Lymph node, Colon, Pancreas, T cells

Animal Models for Acrodermatitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Acrodermatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.8SLC39A4, SLC30A4, ALPL, CD40LG
2MP:00053719.4TMPO, SLC39A2, SLC39A14, SLC39A1, SLC30A5, ALPL
3MP:00107719.2TMPO, OTC, CD40LG, PLIN2, SLC39A1, SLC39A2
4MP:00053799.0ALPL, TMPO, OTC, SLC39A4, SLC30A4, PLIN2
5MP:00053788.4ALPP, PLIN2, SLC30A5, SLC39A1, SLC30A7, SLC39A14

Publications for Acrodermatitis

About this section
Sources:
50PubMed
See all sources

Articles related to Acrodermatitis:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Acrodermatitis enteropathica during adequate enteral nutrition. (22038206)
2012
2
Acrodermatitis enteropathica variant with borderline plasma zinc concentrations. (21502834)
2011
3
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
4
Successful treatment of a 9-year-old boy affected by acrodermatitis continua of Hallopeau with targeted ultraviolet B narrow-band phototherapy. (20070838)
2010
5
Acrodermatitis chronica atrophicans: a case report and review of the literature. (20540415)
2010
6
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
7
Fulminant candida infection in an infant with Acrodermatitis Enteropathica. (19475355)
2009
8
Acrodermatitis continua of Hallopeau responding to efalizumab therapy. (19250321)
2009
9
Acrodermatitis continua resistant to etanercept: therapeutic challenge and unfortunate outcome. (18554224)
2009
10
What caused the rash on this elbow? Papular acrodermatitis of childhood. (18432041)
2008
11
Acrodermatitis continua of Hallopeau on toes successfully treated with a two-compound product containing calcipotriol and betamethasone dipropionate. (17852633)
2007
12
Acrodermatitis enteropathica-like eruption associated with combined nutritional deficiency. (16224175)
2005
13
Acrodermatitis enteropathica-like eruption and food allergy. (15801253)
2005
14
Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. (14592736)
2003
15
Case 4. Transient symptomatic zinc deficiency in a breast-fed premature infant: an acrodermatitis enteropathica-like eruption. (12558652)
2003
16
Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (11254458)
2001
17
Diagnosis: acrodermatitis continua of Hallopeau. (11294139)
2001
18
Acrodermatitis enteropathica with Pseudomonas aeruginosa sepsis. (10632941)
1999
19
Identification of three species of Borrelia burgdorferi sensu lato (B. burgdorferi sensu stricto, B. garinii, and B. afzelii) among isolates from acrodermatitis chronica atrophicans lesions. (9506437)
1998
20
Long-term prognosis in patients treated for erythema chronicum migrans and acrodermatitis chronica atrophicans. (9006370)
1997
21
Serum concentrations of zinc and copper in bull terriers with lethal acrodermatitis and tail-chasing behavior. (9256960)
1997
22
Acrodermatitis enteropathica-like eruption during treatment of maple syrup urine disease: report of one case. (8942030)
1996
23
Acrodermatitis enteropathica-like syndrome in a dialysis patient. (7477640)
1995
24
Bullous lesions in acrodermatitis enteropathica. Histopathologic findings regarding two patients. (1503203)
1992
25
Zinc transport by fibroblasts from patients with acrodermatitis enteropathica. (2484411)
1989
26
Acrodermatitis chronica atrophicans with coexisting morphoea. (2775650)
1989
27
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
28
A striking, papular rash. Papular acrodermatitis of childhood. (3178251)
1988
29
Neuropathy associated with acrodermatitis chronica atrophicans. Clinical and morphological features. (2847621)
1988
30
Ocular histopathology of acrodermatitis enteropathica. (3756122)
1986
31
Copper responsive anemia, induced by oral zinc therapy in a patient with acrodermatitis enteropathica. (4012288)
1985
32
Acrodermatitis enteropathica. (6886096)
1983
33
Successful outcome of two pregnancies in a patient with congenital acrodermatitis enteropathica. (7050774)
1982
34
Hallopeau's acrodermatitis. (453886)
1979
35
Papular acrodermatitis associated with hepatitis B virus infection. (464619)
1979
36
Treatment of Hallopeau's acrodermatitis with triamcinolone acetonide. (666340)
1978
37
Mutilating acrodermatitis continua (Hallopeau's acrodermatitis). (686758)
1978
38
Immune response to hepatitis B virus in children with papular acrodermatitis. (332578)
1977
39
Letter: Plasma-zinc in acrodermatitis enteropathica. (55755)
1976
40
Clinical, biochemical and histochemical studies on infants with Acrodermatitis enteropathica chronica. (829655)
1976
41
Hereditary zinc deficiency (Adema disease) in cattle, an animal parallel to acrodermatitis enteropathica. (58525)
1976
42
Letter: Acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder. (4136854)
1974
43
A case of optic atrophy possibly induced by quinoline in acrodermatitis enteropathica. (4274690)
1974
44
Iatrogenic, corticosteroid-induced acrodermatitis chronica atrophicans. (4682654)
1973
45
Acrodermatitis enteropathica with immune deficiency. (4757511)
1973
46
Evidence for normal metabolism and interconversions of unsaturated fatty acids in acrodermatitis enteropathica. (4757537)
1973
47
Papular acrodermatitis of childhood. An Australia antigen disease. (4749683)
1973
48
Presence of -lipoprotein in serum of patients treated for acrodermatitis enteropathica (Danbolt's disease). (4343518)
1972
49
Acrodermatitis enteropathica. Report of a case in a twin with dramatic response to expressed human milk. (5318960)
1965
50
Acrodermatitis enteropathica. (14476760)
1962

Genetic Variations for Acrodermatitis

About this section

Expression for genes affiliated with Acrodermatitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 53Reactome
See all sources

Compounds for genes affiliated with Acrodermatitis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Acrodermatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1amifostine44 1111.1ALPPL2, ALPL
27,8-dihydroneopterin44 2411.1ALPPL2, ALPP, ALPL
3dihydroneopterin triphosphate44 2411.0ALPL, ALPP, ALPPL2
4dihydroxyacetone44 2411.0ALPL, ALPP, ALPPL2
5phosphoethanolamine449.9ALPP, ALPL
6levamisole44 1110.9ALPPL2, ALPP, ALPL
7alizarin449.7ALPP, ALPL
8aspartate449.6CD40LG, OTC, TMPO, ALPL, ALPP
9zinc44 2410.4SLC30A5, SLC39A1, SLC30A2, SLC30A1, SLC39A2, SLC30A4

GO Terms for genes affiliated with Acrodermatitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Acrodermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.9SLC30A7, SLC39A4, SLC39A2
2anchored to membraneGO:0312259.6ALPP, ALPPL2, ALPL
3plasma membraneGO:0058868.2ALPPL2, CD40LG, ALPP, ALPL, SLC39A4, SLC39A2
4integral to membraneGO:0160217.7SLC30A4, TMPO, ALPL, ALPP, SLC39A5, SLC30A6

Biological processes related to Acrodermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:01004310.2OTC, SLC30A5
2cellular response to zinc ion starvationGO:0342249.9SLC39A4, SLC39A5
3zinc ion transmembrane transportGO:0715779.7SLC39A1, SLC39A14, SLC30A4, SLC30A5
4cellular zinc ion homeostasisGO:0068829.7SLC30A5, SLC39A14, SLC39A4, SLC30A1
5zinc ion transportGO:0068299.3SLC39A5, SLC30A5, SLC39A8, SLC30A2, SLC30A1, SLC30A7
6transmembrane transportGO:0550858.4SLC30A6, SLC39A14, SLC30A7, SLC30A1, SLC30A2, SLC39A8

Molecular functions related to Acrodermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation transmembrane transporter activityGO:00832410.1SLC30A7, SLC30A2
2metal ion transmembrane transporter activityGO:0468739.8SLC39A5, SLC39A8
3alkaline phosphatase activityGO:0040359.8ALPPL2, ALPL, ALPP
4zinc ion transmembrane transporter activityGO:0053858.9SLC39A14, SLC30A5, SLC39A1, SLC39A4, SLC30A4, SLC39A2

Products for genes affiliated with Acrodermatitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acrodermatitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet