MCID: ACR005
MIFTS: 34

Acrodermatitis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

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Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 11 48 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2722
MeSH39 D000169
SNOMED-CT62 8197001
NCIt45 C84532

Summaries for Acrodermatitis

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Wikipedia:71 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

MalaCards based summary: Acrodermatitis is related to acrodermatitis enteropathica and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). Affiliated tissues include skin, breast and liver, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Disease Ontology:11 A dermatitis that selectively affects the hands and feet.

Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica12.4
2acrodermatitis chronica atrophicans12.4
3acrodermatitis continua suppurativa of hallopeau11.9
4gianotti crosti syndrome11.6
5psoriasis 14, pustular11.5
6enteropathica10.8
7zinc deficiency, transient neonatal10.8
8psoriasis susceptibility 110.8
9nephronophthisis10.3ALB, IL36RN
10postencephalitic parkinson disease10.3ALB, CD40LG
11marek disease10.3ALB, CD40LG
12testicular brenner tumor10.3ALB, CD40LG
13adie pupil10.3ALB, CD40LG
14mesangial proliferative glomerulonephritis10.3ALB, CD40LG
15scleral disease10.3ALB, CD40LG
16splenic infarction10.3ALB, CD40LG
17smoldering myeloma10.3ALB, CD40LG
18chromoblastomycosis10.3ALB, CD40LG
19spastic monoplegia10.3ALB, CD40LG
20pyrimidine metabolic disorder10.3ALB, CD40LG
21sweat gland cancer10.3ALB, CD40LG
22balantidiasis10.3ALB, CD40LG
23fibrous histiocytoma10.3ALB, CD40LG
24autoimmune disease of cardiovascular system10.3ALB, CD40LG
2510.2ALB, CXCL10
26adenocarcinoma10.2ALB, CD40LG
27pancreatic vasoactive intestinal peptide producing tumor10.2ALB, CD40LG
28chronic apical periodontitis10.2ALB, CD40LG
29achilles bursitis10.2ALB, CD40LG
30loin pain hematuria syndrome10.2CD40LG, IL36RN
31sarcoid meningitis10.2ALB, CD40LG
32ascending cholangitis10.2ALB, CD40LG
33lymphopenia10.2ALB, CD40LG
34bartter disease10.2ALB, CD40LG
35rocky mountain spotted fever10.2CD40LG, CXCL10
36eczematous dermatitis of eyelid10.2ALB, CD40LG
37alternating exotropia10.2ALB, CD40LG
38small intestine leiomyoma10.2CD40LG, CXCL10
39arcus senilis10.2ALB, CD40LG
40uterine corpus dissecting leiomyoma10.2ALB, CD40LG
41lipid storage disease10.2ALB, CD40LG
42dentin dysplasia10.2CD40LG, CXCL10
43mixed lacrimal gland cancer10.1ALB, CD40LG
44binocular vision disease10.1CD40LG, CXCL10
45membranoproliferative glomerulonephritis10.1CD40LG, CXCL10
46laryngeal tuberculosis10.1ALB, CD40LG
47sheehan syndrome10.1ALB, CD40LG
48progressive relapsing multiple sclerosis10.1CD40LG, CXCL10
49central pontine myelinolysis10.1ALB, CD40LG
50congenital disorder of glycosylation, type ih10.1ALB, CD40LG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9ALB, OTC, PLIN2, SLC39A4
2MP:00053798.4ALB, CD40LG, OTC, PLIN2, SLC39A4
3MP:00107687.6ALB, CD40LG, CXCL10, IL36RN, OTC, SLC39A4
4MP:00053767.5ALB, CD40LG, CXCL10, IL36RN, OTC, PLIN2

Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Zincapproved22317440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Doxycyclineapproved, investigational, vet_approved237564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
5-hydroxy-α-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Anhydrous doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
 
Doxycycline (INN)
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
3Antiparasitic Agents2127
4Antiprotozoal Agents1986
5Antimalarials1216
6Anti-Bacterial Agents10884
7Anti-Infective Agents21402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Study of Severe Zinc DeficienciesCompletedNCT02870166
2Laboratory Characteristics in Chronic Atrophic AcrodermatitisRecruitingNCT02147262
3Borrelia Species in Cutaneous Lyme BorreliosisRecruitingNCT00576082

Search NIH Clinical Center for Acrodermatitis


Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

36
Skin, Breast, Liver, Bone, T cells, Lymph node, Pancreas

Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. (28056538)
2017
2
Acrodermatitis caused by nutritional deficiency and metabolic disorders. (27938814)
2017
3
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. (28017623)
2017
4
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. (27818388)
2016
5
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. (27222886)
2016
6
Acrodermatitis Chronica Atrophicans. (26687575)
2016
7
Pustules of the fingers: acrodermatitis continua. (27026671)
2016
8
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. (27502263)
2016
9
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. (27567652)
2016
10
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. (26856809)
2016
11
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. (26916651)
2016
12
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. (26920763)
2016
13
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. (27231138)
2016
14
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. (26661624)
2016
15
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. (27940220)
2016
16
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. (26955145)
2016
17
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. (27335369)
2016
18
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. (27334242)
2016
19
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. (27904292)
2016
20
Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. (26684640)
2016
21
Acrodermatitis Enteropathica: A Case Report. (27196457)
2016
22
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. (26781226)
2016
23
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. (27683154)
2016
24
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. (25471551)
2015
25
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. (25933075)
2015
26
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. (26465901)
2015
27
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. (26513075)
2015
28
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. (26513074)
2015
29
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. (25780817)
2015
30
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. (26560053)
2015
31
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). (26051055)
2015
32
Histopathology and immunophenotype of acrodermatitis chronica atrophicans correlated with ospA and ospC genotypes of Borrelia species. (26156537)
2015
33
Acrodermatitis enteropathica in an adult. (26244999)
2015
34
Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature. (26367710)
2015
35
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. (26443269)
2015
36
Acrodermatitis enteropathica in an infant with normal zinc levels. (25566908)
2015
37
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. (25468189)
2015
38
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. (26351177)
2015
39
Acrodermatitis Dysmetabolica - Report of Two Cases. (25680786)
2015
40
Ferdinando Gianotti and the papular acrodermatitis of childhood: a scientist against all the odds. (24827010)
2014
41
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. (24962159)
2014
42
Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease. (25540873)
2014
43
Images in clinical medicine. Acquired acrodermatitis enteropathica. (24988559)
2014
44
Case of acrodermatitis continua of Hallopeau following psoriasis with atypical clinical presentation. (25346303)
2014
45
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. (24850624)
2014
46
Fibrous nodules over the patella revealing acrodermatitis chronica atrophicans. (25048097)
2014
47
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. (24783119)
2014
48
Acrodermatitis continua of Hallopeau (ACH): Two cases successfully treated with adalimumab. (24215490)
2014
49
Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. (25147643)
2014
50
Acrodermatitis chronica atrophicans of the face: a case report and a brief review of the literature. (25230062)
2014

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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GO Terms for genes affiliated with Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.6ALB, CD40LG, CXCL10, IL36RN

Sources for Acrodermatitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet