MCID: ACR005
MIFTS: 35

Acrodermatitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 72 49 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2722
MeSH 41 D000169
NCIt 46 C84532
SNOMED-CT 64 8197001
UMLS 69 C0001197

Summaries for Acrodermatitis

Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and pustular psoriasis. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 72 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

Related Diseases for Acrodermatitis

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.0 AP1S3 IL36RN
2 pustular psoriasis 30.1 AP1S3 IL36RN
3 enteropathica 30.0 ALB OTC PLIN2 SLC39A4
4 pustulosis palmaris et plantaris 29.4 AP1S3 IL36RN
5 psoriasis 29.3 AP1S3 CXCL10 IL36RN
6 maple syrup urine disease 29.3 ALB OTC
7 acrodermatitis enteropathica, zinc-deficiency type 12.6
8 acrodermatitis chronica atrophicans 12.5
9 gianotti crosti syndrome 11.7
10 pustulosis of palm and sole 11.3
11 zinc deficiency, transient neonatal 11.2
12 psoriasis 1 10.9
13 hepatitis 10.1
14 cystic fibrosis 10.1
15 hepatitis b 10.1
16 tick-borne encephalitis 10.0 ALB CXCL10
17 acute pyelonephritis 10.0 ALB CXCL10
18 fibrosis of extraocular muscles, congenital, 1 10.0
19 rabies 10.0 ALB CXCL10
20 bulimia nervosa 2 10.0
21 arthritis 10.0
22 dermatitis 10.0
23 neuropathy 10.0
24 primary bacterial infectious disease 9.9 ALB CXCL10
25 australia antigen 9.9
26 lyme disease 9.9
27 celiac disease 1 9.8
28 nephrotic syndrome 9.8
29 diarrhea 9.8
30 blood group--diego system 9.8
31 chromosome 2q35 duplication syndrome 9.8
32 aging 9.8
33 acute lymphocytic leukemia 9.8
34 crohn's disease 9.8
35 leukemia 9.8
36 mucositis 9.8
37 lactose intolerance 9.8
38 short bowel syndrome 9.8
39 squamous cell carcinoma 9.8
40 pancreatitis 9.8
41 pemphigus 9.8
42 pemphigus vegetans 9.8
43 brain edema 9.7 ALB OTC
44 down syndrome 9.6
45 abetalipoproteinemia 9.6
46 enterocolitis 9.6
47 hartnup disorder 9.6
48 netherton syndrome 9.6
49 psoriasis 2 9.6
50 dermatitis, atopic 9.6

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

MGI Mouse Phenotypes related to Acrodermatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 CXCL10 IL36RN OTC PLIN2 SLC39A4 ALB
2 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4

Drugs & Therapeutics for Acrodermatitis

Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3
Zinc Approved, Investigational 7440-66-6 32051 23994
4
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
5 Anti-Bacterial Agents
6 Anti-Infective Agents
7 Antimalarials
8 Antiparasitic Agents
9 Antiprotozoal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
3 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
4 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

Anatomical Context for Acrodermatitis

MalaCards organs/tissues related to Acrodermatitis:

38
Skin, Breast, Bone, Liver, T Cells, Pancreas, Kidney

Publications for Acrodermatitis

Articles related to Acrodermatitis:

(show top 50) (show all 618)
# Title Authors Year
1
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. ( 29058326 )
2018
2
Acrodermatitis acidaemica. ( 29336047 )
2018
3
ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS. ( 29412435 )
2018
4
Dermoscopy in facilitating the recognition of acrodermatitis continua of Hallopeau. ( 28734002 )
2017
5
Diagnosis of acrodermatitis enteropathica in resource limited settings. ( 28768674 )
2017
6
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
7
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2017
8
Highly Resistant Acrodermatitis Continua of Hallopeau and Pustular Psoriasis. ( 29177142 )
2017
9
Acrodermatitis of Hallopeau and erosive oral mucositis successfully treated with secukinumab. ( 28443313 )
2017
10
Acrodermatitis, Enteropathica ( 28722865 )
2017
11
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
12
Acrodermatitis enteropathica in a patient with short bowel syndrome. ( 29232432 )
2017
13
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
14
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
15
Acrodermatitis, Papular (Gianotti Crosti Syndrome) ( 28722855 )
2017
16
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
17
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
18
Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans. ( 29251638 )
2017
19
Acquired Acrodermatitis Enteropathica: A Case Study. ( 29152424 )
2017
20
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
21
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
22
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
23
Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report. ( 29422844 )
2017
24
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
25
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
26
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
27
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
28
Pustules of the fingers: acrodermatitis continua. ( 27026671 )
2016
29
Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. ( 26684640 )
2016
30
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
31
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. ( 27683154 )
2016
32
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
33
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
34
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. ( 28329567 )
2016
35
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
36
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
37
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. ( 27567652 )
2016
38
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. ( 27222886 )
2016
39
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
40
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. ( 27818388 )
2016
41
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. ( 27334242 )
2016
42
Acrodermatitis Chronica Atrophicans. ( 26687575 )
2016
43
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. ( 26856809 )
2016
44
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. ( 26781226 )
2016
45
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2016
46
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
47
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). ( 26051055 )
2015
48
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. ( 26560053 )
2015
49
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. ( 26351177 )
2015
50
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. ( 26465901 )
2015

Variations for Acrodermatitis

Expression for Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for Acrodermatitis

GO Terms for Acrodermatitis

Sources for Acrodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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