MCID: ACR005
MIFTS: 33

Acrodermatitis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

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Aliases & Descriptions for Acrodermatitis:

Name: Acrodermatitis 11 46 13 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:2722
MeSH37 D000169
SNOMED-CT60 8197001
NCIt43 C84532

Summaries for Acrodermatitis

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Wikipedia:69 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the... more...

MalaCards based summary: Acrodermatitis is related to acrodermatitis enteropathica and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). Affiliated tissues include skin, breast and liver, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Disease Ontology:11 A dermatitis that selectively affects the hands and feet.

Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica12.4
2acrodermatitis chronica atrophicans12.4
3acrodermatitis continua suppurativa of hallopeau12.0
4gianotti crosti syndrome11.7
5psoriasis 14, pustular11.2
6enteropathica10.9
7pustulosis of palm and sole10.9
8nephronophthisis10.4ALB, IL36RN
9postencephalitic parkinson disease10.4ALB, CD40LG
10marek disease10.4ALB, CD40LG
11testicular brenner tumor10.4ALB, CD40LG
12adie pupil10.4ALB, CD40LG
13mesangial proliferative glomerulonephritis10.4ALB, CD40LG
14scleral disease10.4ALB, CD40LG
15splenic infarction10.4ALB, CD40LG
16smoldering myeloma10.3ALB, CD40LG
17chromoblastomycosis10.3ALB, CD40LG
18spastic monoplegia10.3ALB, CD40LG
19pyrimidine metabolic disorder10.3ALB, CD40LG
20sweat gland cancer10.3ALB, CD40LG
21balantidiasis10.3ALB, CD40LG
22fibrous histiocytoma10.3ALB, CD40LG
23autoimmune disease of cardiovascular system10.3ALB, CD40LG
24oculocerebrorenal syndrome10.3ALB, CD40LG
25adenocarcinoma10.3ALB, CD40LG
26pancreatic vasoactive intestinal peptide producing tumor10.3ALB, CD40LG
27chronic apical periodontitis10.3ALB, CD40LG
28achilles bursitis10.3ALB, CD40LG
29loin pain hematuria syndrome10.3CD40LG, IL36RN
30sarcoid meningitis10.3ALB, CD40LG
31ascending cholangitis10.3ALB, CD40LG
32lymphopenia10.3ALB, CD40LG
33bartter disease10.3ALB, CD40LG
34eczematous dermatitis of eyelid10.3ALB, CD40LG
35alternating exotropia10.2ALB, CD40LG
36arcus senilis10.2ALB, CD40LG
37uterine corpus dissecting leiomyoma10.2ALB, CD40LG
38lipid storage disease10.2ALB, CD40LG
39mixed lacrimal gland cancer10.2ALB, CD40LG
40hepatitis10.2
41mononeuritis10.2ALB, CD40LG
42laryngeal tuberculosis10.2ALB, CD40LG
43sheehan syndrome10.2ALB, CD40LG
44central pontine myelinolysis10.2ALB, CD40LG
45cystic fibrosis10.2
46hepatitis b10.2
47congenital disorder of glycosylation, type ih10.2ALB, CD40LG
48squamous cell papilloma10.1ALB, CD40LG
49perianal skin paget's disease10.1ALB, CD40LG
50psoriasis10.1

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms for Acrodermatitis

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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Zinc21547440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Doxycycline232564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
Doxycycline (INN)
 
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Study of Severe Zinc DeficienciesCompletedNCT02870166
2Laboratory Characteristics in Chronic Atrophic AcrodermatitisRecruitingNCT02147262
3Borrelia Species in Cutaneous Lyme BorreliosisRecruitingNCT00576082

Search NIH Clinical Center for Acrodermatitis


Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

34
Skin, Breast, Liver, Bone, T cells, Lymph node, Pancreas

Animal Models for Acrodermatitis or affiliated genes

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MGI Mouse Phenotypes related to Acrodermatitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9ALB, OTC, PLIN2, SLC39A4
2MP:00053797.7ALB, CD40LG, OTC, PLIN2, SLC39A4
3MP:00107687.2ALB, CD40LG, CXCL10, IL36RN, OTC, SLC39A4
4MP:00053766.7ALB, CD40LG, CXCL10, IL36RN, OTC, PLIN2

Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Ferdinando Gianotti and the papular acrodermatitis of childhood: a scientist against all the odds. (24827010)
2014
2
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
3
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
4
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
5
Acrodermatitis chronica atrophicans: a case report and review of the literature. (20540415)
2010
6
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
7
Excellent and prolonged response to infliximab in a case of recalcitrant acrodermatitis continua of Hallopeau. (18785890)
2009
8
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
9
Acrodermatitis enteropathica-like simulating severe atopic dermatitis: a case report. (18680706)
2008
10
Identification of a unique splice site variant in SLC39A4 in bovine hereditary zinc deficiency, lethal trait A46: An animal model of acrodermatitis enteropathica. (16714095)
2006
11
Acrodermatitis enteropathica-like eruption associated with combined nutritional deficiency. (16224175)
2005
12
Acquired syndactyly secondary to acrodermatitis continua of Hallopeau. (15888186)
2005
13
Successful treatment of acrodermatitis continua of Hallopeau by the tumour necrosis factor-alpha inhibitor infliximab (Remicade). (14996123)
2004
14
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? (12705767)
2003
15
Using oral tetracycline and topical betamethasone valerate to treat acrodermatitis continua of hallopeau. (12234156)
2002
16
Joint and bone involvement in Dutch patients with Lyme borreliosis presenting with acrodermatitis chronica atrophicans. (10048289)
1999
17
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
18
The acrodermatitis enteropathica mutation transiently affects zinc metabolism in human fibroblasts. (8558304)
1996
19
Acrodermatitis enteropathica-like eruption during treatment of maple syrup urine disease: report of one case. (8942030)
1996
20
Success and failure in the treatment of acrodermatitis chronica atrophicans. (8852478)
1996
21
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. (7778918)
1995
22
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. (7908489)
1994
23
Acrodermatitis chronica atrophicans involving the face. Evidence for Borrelia burgdorferi infection confirmed by DNA amplification. (7873838)
1994
24
Acrodermatitis chronica atrophicans in the United States: clinical and histopathologic features of six cases. (7956339)
1994
25
Serological follow-up after treatment of Borrelia arthritis and acrodermatitis chronica atrophicans. (7939435)
1994
26
Lyme borreliosis presenting as acrodermatitis chronica atrophicans. (1579190)
1992
27
Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (1986705)
1991
28
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
29
Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans. (4013743)
1985
30
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
31
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
32
Maternal essential fatty acid supplementation increases zinc absorption in neonatal rats: relevance to the defect in zinc absorption in acrodermatitis enteropathica. (7110781)
1982
33
Papular acrodermatitis (Gianotti-Crosti syndrome) in a child with anicteric hepatitis B, virus subtype adw. (7097415)
1982
34
Is acrodermatitis enteropathica related to the absence of zinc binding ligand in bovine milk? (570352)
1979
35
The acrodermatitis enteropathica-like syndrome. (109049)
1979
36
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
37
Papular acrodermatitis of childhood. (The Gianotti-Crosti disease). An Australia antigen disease. (757836)
1978
38
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
39
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
40
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
41
Reversible intestinal mucosal abnormality in acrodermatitis enteropathica. (952555)
1976
42
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
43
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
44
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
45
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
46
Iatrogenic, corticosteroid-induced acrodermatitis chronica atrophicans. (4682654)
1973
47
Case for diagnosis: acrodermatitis enteropathica vs sebopsoriasis. (4248273)
1970
48
Acrodermatitis enteropathica. Report of a case in a twin with dramatic response to expressed human milk. (5318960)
1965
49
Infantile lichenoid acrodermatitis. Report of a case of Gianotti-Crosti syndrome. (5835329)
1965
50
Acrodermatitis enteropathica; report of two additional cases. (18101569)
1948

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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GO Terms for genes affiliated with Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3ALB, CD40LG, CXCL10, IL36RN

Sources for Acrodermatitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet