MCID: ACR005
MIFTS: 55

Acrodermatitis malady

Rare diseases, Skin diseases categories

Summaries for Acrodermatitis

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66Wikipedia, 34MalaCards
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MalaCards: Acrodermatitis is related to acrodermatitis enteropathica and hepatitis. An important gene associated with Acrodermatitis is SLC39A4 (solute carrier family 39 (zinc transporter), member 4), and among its related pathways are Inflammatory Response Pathway and Cellular roles of Anthrax toxin. The compounds gamma globulin and auranofin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Acrodermatitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

acrodermatitis 9 44 11 63


External Ids:

Disease Ontology9 DOID:2722
MeSH36 D000169
SNOMED-CT59 8197001
NCIt41 C84532

Related Diseases for Acrodermatitis

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18GeneCards, 19GeneDecks
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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica31.8SLC39A1, SLC30A4, SLC39A5, SLC39A4, SLC30A5
2hepatitis30.7CXCL10, OTC, CD40LG
3hepatitis b30.5ALB, IFNG, CXCL10
4dermatitis30.3IFNG, CXCL10, CXCL9
5arthritis30.2IL1B, TNF
6psoriasis30.2TNF, CXCL10, CXCL9, IFNG, IL1B
7leukemia29.9TNF, OTC, IFNG, CD40LG, IL1B
8psoriatic arthritis29.9TNF, IL1B
9arthropathy29.8TNF, CXCL10, IL1B
10sepsis29.8IL1B, TNF, CXCL9, ALB
11atopic dermatitis29.7CXCL9, IFNG, TNF, CXCL10
12ulcerative colitis29.7CXCL10, IFNG, IL1B, TNF
13enteropathica11.2
14cystic fibrosis10.4
15gianotti crosti syndrome10.4
16neuropathy10.3
17lyme disease10.2
18anorexia nervosa10.2
19diarrhea10.1
20peripheral neuropathy10.1
21acrodermatitis continua suppurativa of hallopeau10.1
22hemorrhagic fever10.1CD40LG
23schnitzler syndrome10.1CD40LG
24hepatorenal syndrome10.1ALB
25degenerative disc disease10.1IL1B
26pleurisy10.1IL1B
27acute liver failure10.1ALB, OTC
28brain edema10.1ALB, OTC
29alopecia areata10.1IFNG
30crohn's disease10.1
31maple syrup urine disease10.1
32lactose intolerance10.1
33acute lymphocytic leukemia10.1
34nephrotic syndrome10.1
35optic atrophy10.1
36pancreatitis10.1
37hepatitis b virus infection10.1
38biliary atresia10.1CXCL10, OTC
39alcoholic hepatitis10.0ALB, TNF
40paracoccidioidomycosis10.0CXCL10, CXCL9
41allergic contact dermatitis10.0CXCL9, CXCL10
42mastitis10.0ALB, IL1B
43blau syndrome10.0IL1B, TNF
44brain disease10.0OTC, ALB, CXCL10
45aids dementia complex10.0IL1B, TNF
46familial mediterranean fever10.0IL1B, TNF
47connective tissue disease10.0CD40LG, ALB, TNF
48chorioamnionitis10.0TNF, IL1B
49vasculitis10.0ALB, CD40LG, TNF
50leishmaniasis10.0IFNG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to acrodermatitis

Symptoms for Acrodermatitis

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Drugs & Therapeutics for Acrodermatitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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34MalaCards
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MalaCards organs/tissues related to Acrodermatitis:

34
Skin, Breast, Liver, Bone, Lymph node, Eye, Colon, T cells, Pancreas

Animal Models for Acrodermatitis or affiliated genes

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38MGI
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Publications for Acrodermatitis

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53PubMed
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Articles related to Acrodermatitis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
2
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
3
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
4
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
5
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
6
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. (17599860)
2007
7
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. (17483098)
2007
8
Acrodermatitis enteropathica-like dermatosis associated with ornithine transcarbamylase deficiency. (17845164)
2007
9
Etanercept and recalcitrant acrodermatitis continua of Hallopeau. (16991229)
2006
10
Nutritional zinc deficiency mimicking acrodermatitis enteropathica in a fully breast-fed infant. (17062090)
2006
11
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? (12705767)
2003
12
Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (11254458)
2001
13
Diagnosis: acrodermatitis continua of Hallopeau. (11294139)
2001
14
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis. (9687549)
1998
15
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
16
Acrodermatitis chronica atrophicans in an Italian child. (8800311)
1996
17
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. (7778918)
1995
18
An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. (8186509)
1994
19
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. (7908489)
1994
20
Acrodermatitis chronica atrophicans involving the face. Evidence for Borrelia burgdorferi infection confirmed by DNA amplification. (7873838)
1994
21
Lyme borreliosis presenting as acrodermatitis chronica atrophicans. (1579190)
1992
22
Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (1986705)
1991
23
Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. (3056202)
1988
24
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
25
Natural history of infantile papular acrodermatitis (Gianotti's disease) with HBsAg subtype adw. (3236828)
1988
26
Childhood acquired immune deficiency syndrome manifesting as acrodermatitis enteropathica. (2936876)
1986
27
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
28
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
29
The effects of diet and zinc treatment on the fatty acid composition of serum lipids and adipose tissue and on serum lipoproteins in two adolescent patients with acrodermatitis enteropathica. (6624693)
1983
30
Detection of hepatitis B surface antigen subtype adr in an epidemic of papular acrodermatitis of childhood (Gianotti's disease). (6459711)
1981
31
Percutaneous absorption of zinc in acrodermatitis enteropathica. (7333397)
1981
32
Acrodermatitis enteropathica, immunodeficiency, and zinc. (630912)
1978
33
Zinc therapy of acrodermatitis enteropathica. (659045)
1978
34
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
35
Animal model of human disease. Acrodermatitis enteropathica, zinc malabsorption. (559415)
1977
36
Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies. (196972)
1977
37
Letter: Plasma-zinc in acrodermatitis enteropathica. (55755)
1976
38
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
39
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
40
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
41
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
42
Determination of oxyquinoline concentrations in plasma in a patient treated for acrodermatitis enteropathica--an aid in therapeutic control. (4426461)
1974
43
Letter: Hepatitis B antigen in papular acrodermatitis in children. (4843656)
1974
44
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
45
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
46
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
47
Zinc deficiency in acrodermatitis enteropathica: multiple dietary intolerance treated with synthetic diet. (4577330)
1973
48
Acrodermatitis enteropathica with lactose intolerance. (5085934)
1972
49
Acrodermatitis enteropathica. (4918455)
1969
50
Acrodermatitis enteropathica. (4229461)
1967

Variations for Acrodermatitis

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Expression for genes affiliated with Acrodermatitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for genes affiliated with Acrodermatitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 55R&D Systems, 31KEGG, 56Reactome
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Pathways related to Acrodermatitis according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD40LG, IFNG
29.6TNF, IL1B
39.6TNF, IL1B
4
Show member pathways
Serotonin Transporter Activity39
9.6TNF, IL1B
59.6IL1B, TNF
69.6IFNG, TNF
7
Show member pathways
9.6IFNG, TNF
8
Show member pathways
9.6IFNG, TNF
99.6CXCL9, CXCL10
109.4TNF, IL1B, CD40LG
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3CD40LG, IFNG, TNF
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.3TNF, IL36RN, IL1B
139.3IL1B, CXCL10, TNF
149.2TNF, IFNG, IL1B
159.2TNF, IFNG, IL1B
169.2TNF, IFNG, IL1B
179.2TNF, IFNG, IL1B
189.2TNF, IFNG, IL1B
199.2IL1B, IFNG, TNF
209.2IL1B, IFNG, TNF
21
Show member pathways
9.2IL1B, IFNG, TNF
22
Show member pathways
Immune response MIF in innate immunity response61
9.2IL1B, IFNG, TNF
239.2IL1B, IFNG, TNF
249.2IL1B, IFNG, TNF
25
Show member pathways
IL27-mediated signaling events39
9.2IL1B, IFNG, TNF
26
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.0CD40LG, IL1B, IFNG, TNF
27
Show member pathways
9.0TNF, IFNG, IL1B, CD40LG
289.0TNF, IFNG, IL1B, CD40LG
29
Show member pathways
9.0TNF, IFNG, IL1B, CD40LG
30
Show member pathways
thioredoxin pathway39
8.9TNF, IFNG, IL1B, ALB
31
Show member pathways
8.9SLC30A5, SLC39A4, SLC39A1, SLC39A5
328.9IL1B, IFNG, CXCL10, TNF
33
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.9IL1B, IFNG, CXCL10, TNF
34
Show member pathways
8.9IL1B, IFNG, CXCL10, TNF
358.8CXCL10, CXCL9, IFNG, IL1B
36
Show member pathways
8.8TNF, CXCL10, CXCL9, IL1B
37
Show member pathways
8.8TNF, CXCL10, CXCL9, IL1B
38
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.7TNF, CXCL9, IFNG, IL1B
398.6IFNG, IL1B, SLC39A1, SLC39A4
40
Show member pathways
8.6SLC30A5, SLC39A4, SLC39A1, SLC39A5, ALB
41
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.4IL1B, IFNG, CXCL9, CXCL10, TNF
42
Show member pathways
8.1TNF, CXCL10, CXCL9, IFNG, IL1B, CD40LG

Compounds for genes affiliated with Acrodermatitis

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46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Acrodermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1gamma globulin469.9ALB, CD40LG, IFNG
2auranofin30 46 62 1212.8IFNG, ALB, IL1B
3aminoguanidine46 30 1211.8ALB, IL1B, IFNG
4okt3469.6CD40LG, TNF, IFNG
5vesnarinone469.6TNF, IL1B, IFNG
6taurine chloramine469.6IL1B, IFNG, TNF
7gold sodium thiomalate469.6IL1B, TNF, IFNG
8sulfasalazine30 46 52 1212.6CD40LG, IL1B, TNF
9staurosporin469.6IL1B, IFNG, TNF
10polymyxin b469.6IL1B, IFNG, TNF
11triptolide469.5IFNG, TNF, IL1B
12gm-csf46 3010.5IFNG, TNF, IL1B
13budesonide46 52 1211.5IL1B, IFNG, TNF
14ribavirin46 52 1211.5CXCL10, IFNG, CD40LG
152,5-oligoadenylate469.5TNF, CXCL10, IFNG
16mycophenolate mofetil46 52 1211.4TNF, IFNG, ALB, CD40LG
17allergens469.4CXCL10, IFNG, CD40LG
18il-12469.4IL1B, IFNG, CD40LG, TNF
19etanercept46 52 1211.4IFNG, TNF, IL1B
20l-nmma469.3IFNG, TNF, IL1B
21thalidomide46 52 62 1212.3IFNG, TNF, CD40LG, IL1B
22fluticasone propionate46 52 62 1212.3CXCL10, IFNG, TNF, IL1B
23polyinosinic-polycytidylic acid469.3IL1B, TNF, CXCL10, IFNG
24poly(i-c)469.3IL1B, TNF, CXCL10, IFNG
25infliximab46 52 1211.3TNF, IL1B, IFNG, CXCL10
26ciglitazone46 3010.3TNF, IL1B, PLIN2
27herbimycin a46 6210.3TNF, IFNG, CD40LG, IL1B
28hydrocortisone46 3 62 1212.3CXCL10, IL1B, TNF, IFNG
29pentoxifylline46 1210.2IL1B, IFNG, TNF
30groalpha469.2CXCL9, IL1B, CXCL10, TNF
31tacrolimus46 52 1211.2CXCL10, TNF, ALB, IFNG
32tarc469.2CXCL9, CXCL10, TNF, IFNG
33calcitriol46 62 25 1212.1ALB, TNF, IL1B, IFNG
34ifn-alpha469.1CXCL10, IFNG, CXCL9
35ivig469.1ALB, CD40LG, IL1B, IFNG, TNF
36ionomycin469.1TNF, CXCL9, IFNG, CD40LG
37neopterin469.0CXCL10, TNF, CD40LG, IL1B, IFNG
38indomethacin46 30 62 1212.0ALB, IL1B, IFNG, TNF, CD40LG
39creatinine469.0OTC, CD40LG, ALB, CXCL9, CXCL10
40genistein46 30 62 3 25 1214.0CD40LG, IFNG, IL1B, CXCL10, TNF
4115-deoxy-delta-12,14-prostaglandin j2468.9IFNG, IL1B, TNF
42il 10468.8IL1B, IFNG, CXCL9, CXCL10, TNF
43ccl346 309.8TNF, CXCL10, CXCL9, IFNG, IL1B
44endotoxin468.5CD40LG, TNF, CXCL10, CXCL9, IFNG, IL1B
45rantes468.5IL1B, IFNG, CXCL9, CXCL10, TNF, CD40LG
46dexamethasone46 52 30 1211.5TNF, CXCL10, CD40LG, IL1B, IFNG, CXCL9
47nitric oxide46 25 1210.4OTC, IFNG, CXCL10, IL1B, TNF, CXCL9
48pge2468.4CD40LG, PLIN2, IL1B, IFNG, CXCL10, TNF
49histamine46 30 2510.2CXCL9, IFNG, IL1B, ALB, TNF, CD40LG
50vegf467.9CD40LG, TNF, CXCL10, CXCL9, IFNG, PLIN2

GO Terms for genes affiliated with Acrodermatitis

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17Gene Ontology
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Cellular components related to Acrodermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD40LG, IFNG, CXCL9, CXCL10, TNF
2extracellular regionGO:0055767.4TNF, CXCL10, CXCL9, IFNG, IL1B, PLIN2
3extracellular spaceGO:0056157.4IL36RN, CXCL9, IL1B, ALB, CD40LG, CXCL10

Biological processes related to Acrodermatitis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cellular response to zinc ion starvationGO:03422410.4SLC39A5, SLC39A4
2cellular zinc ion homeostasisGO:00688210.3SLC30A5, SLC39A4
3zinc ion transportGO:00682910.3SLC30A5, SLC39A5
4regulation of immunoglobulin secretionGO:05102310.1TNF, CD40LG
5response to zinc ionGO:01004310.1SLC30A5, OTC
6positive regulation of interleukin-6 biosynthetic processGO:04541010.0IFNG, IL1B
7sequestering of triglycerideGO:03073010.0IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
9positive regulation of fever generationGO:03162210.0TNF, IL1B
10positive regulation of vitamin D biosynthetic processGO:06055710.0TNF, IFNG
11regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.0IL1B, TNF
12positive regulation of cAMP metabolic processGO:03081610.0CXCL10, CXCL9
13positive regulation of interleukin-12 productionGO:03273510.0IFNG, CD40LG
14negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
15negative regulation of interleukin-6 productionGO:0327159.9TNF, IL36RN
16positive regulation of cAMP-mediated signalingGO:0439509.9CXCL10, CXCL9
17positive regulation of NF-kappaB import into nucleusGO:0423469.9IL1B, TNF
18negative regulation of growth of symbiont in hostGO:0441309.9TNF, IFNG
19positive regulation of osteoclast differentiationGO:0456729.9IFNG, TNF
20positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8CXCL9, CXCL10
21protein import into nucleus, translocationGO:0000609.8IFNG, TNF
22lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL1B, TNF
23positive regulation of mitosisGO:0458409.7TNF, IL1B
24positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, IFNG, TNF
25positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IFNG, IL1B
26protein kinase B signalingGO:0434919.6IL1B, TNF
27positive regulation of membrane protein ectodomain proteolysisGO:0510449.6TNF, IFNG, IL1B
28positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, IFNG, TNF
29regulation of insulin secretionGO:0507969.6TNF, IFNG, IL1B
30negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1B, TNF
31defense response to virusGO:0516079.5CXCL10, CXCL9, IFNG
32cellular response to organic cyclic compoundGO:0714079.3TNF, IL1B
33zinc ion transmembrane transportGO:0715779.3SLC30A5, SLC30A4, SLC39A1
34cell-cell signalingGO:0072679.2IL1B, CXCL9, CXCL10
35response to drugGO:0424939.1OTC, PLIN2, IFNG, TNF
36transmembrane transportGO:0550859.0ALB, SLC39A5, SLC39A1, SLC39A4, SLC30A5
37inflammatory responseGO:0069548.9TNF, CXCL10, CXCL9, IL1B, CD40LG

Molecular functions related to Acrodermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.7TNF, CD40LG
2CXCR3 chemokine receptor bindingGO:0482489.5CXCL9, CXCL10
3interleukin-1 receptor bindingGO:0051499.5IL36RN, IL1B
4zinc ion transmembrane transporter activityGO:0053858.7SLC30A5, SLC39A4, SLC30A4, SLC39A1
5cytokine activityGO:0051258.1TNF, CXCL9, IFNG, IL36RN, IL1B, CD40LG

Products for genes affiliated with Acrodermatitis

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Sources for Acrodermatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet