MCID: ACR005
MIFTS: 35

Acrodermatitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 50 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2722
MeSH 42 D000169
NCIt 47 C84532
SNOMED-CT 64 8197001
UMLS 69 C0001197

Summaries for Acrodermatitis

Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to acrodermatitis enteropathica and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

Related Diseases for Acrodermatitis

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
id Related Disease Score Top Affiliating Genes
1 acrodermatitis enteropathica 12.4
2 acrodermatitis chronica atrophicans 12.3
3 acrodermatitis continua suppurativa of hallopeau 11.9
4 gianotti crosti syndrome 11.6
5 psoriasis 14, pustular 11.4
6 enteropathica 10.8
7 zinc deficiency, transient neonatal 10.8
8 psoriasis susceptibility 1 10.8
9 chronic gonococcal salpingitis 10.5 ALB IL36RN
10 middle ear carcinoma 10.4 ALB CD40LG
11 microinvasive cervical squamous cell carcinoma 10.4 ALB CD40LG
12 estrogen excess 10.4 ALB CD40LG
13 fragile x syndrome type 2 10.4 ALB CD40LG
14 adie pupil 10.4 ALB CD40LG
15 immune-complex glomerulonephritis 10.4 ALB CD40LG
16 chronic inflammatory demyelinating polyneuritis 10.4 ALB CD40LG
17 motion sickness 10.4 ALB CD40LG
18 adrenal gland disease 10.4 ALB CD40LG
19 vulvar sarcoma 10.4 ALB CD40LG
20 dermatomycosis 10.4 ALB CD40LG
21 pyrimidine metabolic disorder 10.4 ALB CD40LG
22 common cold 10.4 ALB CD40LG
23 hepadnavirus infection 10.3 ALB CD40LG
24 bladder diverticulum 10.3 ALB CD40LG
25 erythema multiforme 10.3 ALB CXCL10
26 autoimmune disease of cardiovascular system 10.3 ALB CD40LG
27 spastic entropion 10.3 ALB CD40LG
28 breast papillary carcinoma 10.3 ALB CXCL10
29 cutaneous fibrous histiocytoma 10.3 ALB CD40LG
30 plummer's disease 10.3 ALB CD40LG
31 late yaws 10.3 ALB CD40LG
32 pyridoxine deficiency 10.3 CD40LG IL36RN
33 benign mammary dysplasia 10.3 ALB CD40LG
34 dentinogenesis imperfecta 10.3 ALB CD40LG
35 choreatic disease 10.3 ALB CD40LG
36 rocky mountain spotted fever 10.3 CD40LG CXCL10
37 malignant eyelid melanoma 10.3 CD40LG CXCL10
38 acute cholangitis 10.3 ALB CD40LG
39 prostate neuroendocrine neoplasm 10.2 ALB CD40LG
40 drug psychosis 10.2 CD40LG CXCL10
41 lymphoma 10.2 ALB CD40LG
42 hemolytic anemia due to triosephosphate isomerase deficiency 10.2 CD40LG CXCL10
43 uterus interstitial leiomyoma 10.2 ALB CD40LG
44 nasal cavity carcinoma in situ 10.2 ALB CD40LG
45 restless legs syndrome 10.2 CD40LG CXCL10
46 isthmus cancer 10.2 ALB CD40LG
47 transmitted_by 10.2 CD40LG CXCL10
48 premature ovarian failure 12 10.2 ALB CD40LG
49 newcastle disease 10.2 CD40LG CXCL10
50 acute chest syndrome 10.2 ALB CD40LG

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

MGI Mouse Phenotypes related to Acrodermatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 ALB CD40LG OTC PLIN2 SLC39A4
2 homeostasis/metabolism MP:0005376 9.5 ALB CD40LG CXCL10 IL36RN OTC PLIN2
3 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4

Drugs & Therapeutics for Acrodermatitis

Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3
Zinc Approved 7440-66-6 32051 23994
4
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
5 Anti-Bacterial Agents
6 Anti-Infective Agents
7 Antimalarials
8 Antiparasitic Agents
9 Antiprotozoal Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
3 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
4 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

Anatomical Context for Acrodermatitis

MalaCards organs/tissues related to Acrodermatitis:

39
Skin, Breast, Liver, Pancreas, Bone, Kidney, T Cells

Publications for Acrodermatitis

Articles related to Acrodermatitis:

(show top 50) (show all 611)
id Title Authors Year
1
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
2
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
3
Acrodermatitis, Papular (Gianotti Crosti Syndrome) ( 28722855 )
2017
4
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
5
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
6
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
7
Acrodermatitis of Hallopeau and erosive oral mucositis successfully treated with secukinumab. ( 28443313 )
2017
8
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2017
9
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
10
Dermoscopy in facilitating the recognition of acrodermatitis continua of Hallopeau. ( 28734002 )
2017
11
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
12
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
13
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
14
Diagnosis of acrodermatitis enteropathica in resource limited settings. ( 28768674 )
2017
15
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
16
Acrodermatitis, Enteropathica ( 28722865 )
2017
17
Acrodermatitis Chronica Atrophicans. ( 26687575 )
2016
18
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
19
Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. ( 26684640 )
2016
20
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. ( 27683154 )
2016
21
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
22
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. ( 27222886 )
2016
23
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. ( 27567652 )
2016
24
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
25
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. ( 27334242 )
2016
26
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
27
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
28
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
29
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. ( 28329567 )
2016
30
Pustules of the fingers: acrodermatitis continua. ( 27026671 )
2016
31
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. ( 27818388 )
2016
32
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
33
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
34
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. ( 26781226 )
2016
35
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. ( 26856809 )
2016
36
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
37
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2016
38
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
39
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. ( 25933075 )
2015
40
Acrodermatitis enteropathica in an infant with normal zinc levels. ( 25566908 )
2015
41
Acrodermatitis enteropathica in an adult. ( 26244999 )
2015
42
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. ( 25468189 )
2015
43
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). ( 26051055 )
2015
44
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. ( 26513075 )
2015
45
Acrodermatitis Dysmetabolica - Report of Two Cases. ( 25680786 )
2015
46
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. ( 25471551 )
2015
47
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. ( 26465901 )
2015
48
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. ( 26351177 )
2015
49
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. ( 26513074 )
2015
50
Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature. ( 26367710 )
2015

Variations for Acrodermatitis

Expression for Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for Acrodermatitis

GO Terms for Acrodermatitis

Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ALB CD40LG CXCL10 IL36RN PLIN2

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.13 CD40LG CXCL10 IL36RN
2 inflammatory response GO:0006954 8.8 CD40LG CXCL10 IL36RN

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CD40LG CXCL10 IL36RN

Sources for Acrodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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