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MCID: ACR007
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Acromegaly malady |
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5 drugs, 113 genes, 24 tissues, 1000 related diseases, 27 phenotypes, 663 articles, clinical trials.
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
NIH Rare Diseases: Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.30
MalaCards: Acromegaly, also known as growth hormone excess, is related to mccune albright syndrome and cushing's syndrome. An important gene associated with Acromegaly is GH1 (growth hormone 1), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Glioma Invasiveness. The drugs bromocriptine and bromocriptine mesylate and the compounds 25-hydroxyvitamin d and 17-hydroxyprogesterone have been mentioned in the context of this disorder. Affiliated tissues include limb, brain and heart, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland. Disease Ontology: A disease of metabolism that has material basis in excessive growth hormone production which results in enlargement located in limb.6 Wikipedia: Acromegaly (pron.: /ˌækrɵˈmɛɡəli/; from Greek άκρος akros \"extreme\" or \"extremities\" and...44 more... OMIM: 102200 |
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Sources: 6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 102200
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for acromegaly Drug clinical trials:Search ClinicalTrials for acromegaly Search NIH Clinical Center for acromegaly Search CenterWatch for acromegaly Inferred drug relations via UMLS/NDF-RT:43 28 bromocriptine, bromocriptine mesylate, octreotide, octreotide acetate, pegvisomant |
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Sources: 11FMA, 22MalaCards See all sources |
MalaCards organs/tissues related to acromegaly:22Brain, Heart, Skeletal muscle, Small intestine, Colon, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Skin, Ovary, Prostate, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal thyroid, Pancreatic islet, Pituitary FMA organs/tissues related to acromegaly:11Limb
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to acromegaly:25 (show all 27)
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Sources: 35PubMed See all sources |
Articles related to acromegaly:(show top 50) (show all 663)
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Sources: 1BioGPS See all sources |
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Sources: 41Thomson Reuters, 36QIAGEN, 38Reactome, 37R&D Systems, 10EMD Millipore, 20KEGG See all sources |
Pathways related to acromegaly according to GeneDecks:(show top 50) (show all 73)
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Sources: 32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB See all sources |
Compounds related to acromegaly according to GeneDecks:(show top 50) (show all 519)
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Sources: 12Gene Ontology See all sources |
Cellular components related to acromegaly according to GeneDecks:
Biological processes related to acromegaly according to GeneDecks:(show top 50) (show all 66)
Molecular functions related to acromegaly according to GeneDecks:(show all 12)
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