MCID: ACR007
MIFTS: 75

Acromegaly malady

Endocrine, Cancer categories

Summaries for Acromegaly

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (gh). it is most often diagnosed in middle-aged adults, although symptoms can appear at any age. signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. the condition is usually caused by benign tumors on the pituitary called adenomas. rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. when gh-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. last updated: 4/29/2011

MalaCards: Acromegaly, also known as gigantism, is related to adenoma and gigantism, and has symptoms including kyphosis, autosomal dominant inheritance and coarse face. An important gene associated with Acromegaly is GNAS (GNAS complex locus), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs bromocriptine and octreotide and the compounds acth and octreotide have been mentioned in the context of this disorder. Affiliated tissues include limb, skin and ovary, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Disease Ontology:8 A disease of metabolism that has material basis in excessive growth hormone production which results in enlargement located in limb.

Wikipedia:64 Acromegaly (/ˌækrɵˈmɛɡəli/; from Greek άκρος akros \"extreme\" or \"extremities\" and... more...

Description from OMIM:47 102200

Aliases & Classifications for Acromegaly

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Characteristics (Orphanet epidemiological data):

49
acromegaly:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acromegaly 8 9 43 47 10 45 49 61
gigantism 49 61
infantile and juvenile forms of acromegaly 49
growth hormone excess 43
somatotroph adenoma 43
pituitary giant 43


External Ids:

Disease Ontology8 DOID:2449
NCIt40 C84533
MeSH35 D000172
OMIM47 102200
MESH via Orphanet36 D000172, D005877
ICD10 via Orphanet26 E22.0
SNOMED-CT via Orphanet58 74107003, 80849007
UMLS via Orphanet62 C0001206, C0017547

Related Diseases for Acromegaly

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acromegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 366)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1TRHR, GHRH, GHRHR, GHR, AIP, TRH
2gigantism30.8GNAS, AIP, IGF1, SST, PRL, GH1
3pituitary apoplexy30.8TRH, PRL
4mccune albright syndrome30.7PRL, GH1, GNAS
5growth hormone deficiency30.7IGF1, IGFBP3, PRL, GH1, GHRH, GHSR
6insulin resistance30.6GH1, GHR, GNAS, SST, IGFBP3, IGF1
7pituitary tumors30.6SSTR2, CNC, GNAS, GHRH, GHSR, GHR
8prolactinoma30.5GNAS, GAL, MEN1, TRH, TRHR, AIP
9hyperprolactinemia30.4VIP, GNAS, GAL, TRH, IGF1, SST
10cushing's syndrome30.4SST, GH1
11multiple endocrine neoplasia30.4CNC, MEN1, GNAS, VIP
12fibrous dysplasia30.3GH1, GNAS, GHR
13dwarfism30.2GH1, IGF1, IGFBP3, GHRH, GHR, GHRHR
14carney complex30.2AIP, GNAS, MEN1
15empty sella syndrome30.2PRL, TRH
16atherosclerosis30.2GHSR, IGF1
17amenorrhea30.1TRH, IGF1, PRL
18carcinoid syndrome30.1SST, SSTR1, SSTR2, SSTR5, GH1, GHRH
19acanthosis nigricans30.1IGF1
20glucose intolerance30.1IGF1, GH1, IGFBP3
21thyroid cancer30.1GNAS, GHSR, TRH
22hypoglycemia29.9TRH, IGF1, IGFBP3, SST, PRL, GH1
23panhypopituitarism29.9PRL, IGF1, GH1, GHR
24diabetes insipidus29.9GHRH, TRH, PRL
25zollinger-ellison syndrome29.9SST, MEN1, GHRH
26proliferative diabetic retinopathy29.9SST, IGF1, IGFBP3, GHR
27chromophobe adenoma29.9GH1, PRL
28arthritis29.9GAL, VIP
29neurofibromatosis29.9SST, GHR, MEN1
30thyroid adenoma29.9GNAS, CNC
31nelson syndrome29.9PRL, SST
32mental retardation29.9VIP, GNAS, GHR
33pheochromocytoma29.7VIP, SST, SSTR1, SSTR2, GNAS, GAL
34adenocarcinoma29.7MEN1, GAL, VIP, GHR, SSTR2, SSTR1
35hyperandrogenism29.7IGFBP3, GNAS, PRL, IGF1, GH1
36colorectal cancer29.7GAL, SSTR2, IGF1, IGFBP3
37thyroiditis29.7TRH
38polycystic ovary syndrome29.7IGF1, IGFBP3, GH1, PRL
39turner syndrome29.7IGF1, IGFBP3, GHR
40uremia29.7GH1, MEN1, IGF1, GHR
41thyroid medullary carcinoma29.7MEN1, SSTR2, SSTR1, SSTR5, SST
42graves' disease29.7GNAS
43rabson-mendenhall syndrome29.7IGF1, IGFBP3
44adrenal adenoma29.7GNAS, CNC, MEN1
45acth deficiency29.7PRL, GH1
46astrocytoma29.7GHR
47osteoporosis29.7GHR, GH1, IGFBP3, IGF1
48cholera29.7TRH, VIP, GNAS, GAL
49somatostatin analog10.9
50sotos syndrome10.6

Graphical network of the top 20 diseases related to Acromegaly:



Diseases related to acromegaly

Clinical Features for Acromegaly

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

102200

Symptoms:

49 (show all 19)
  • kyphosis
  • autosomal dominant inheritance
  • coarse face
  • macroglossia/tongue protrusion/proeminent/hypertrophic
  • long/large ear
  • prognathism/prognathia
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • thick lips
  • hirsutism/hypertrichosis/increased body hair
  • long/large/bulbous nose
  • enlarged diaphysis/diaphyses
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism
  • tall stature/gigantism/growth acceleration
  • long face
  • macropenis/megapenis/large penis
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • synophris/synophrys
  • large hand
  • tapered fingers

Drugs & Therapeutics for Acromegaly

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acromegaly

Drug clinical trials:

Search ClinicalTrials for Acromegaly

Search NIH Clinical Center for Acromegaly

Search CenterWatch for Acromegaly

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Acromegaly

Anatomical Context for Acromegaly

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Acromegaly:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lung, Uterus, Whole blood, Heart, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, Cervix, Tonsil, Myeloid, B cells, Endothelial, Fetal brain, Hypothalamus, Fetal liver, Fetal thyroid, Pancreatic islet, Pituitary, Uterus corpus

FMA organs/tissues related to Acromegaly:

14
Limb

Animal Models for Acromegaly or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acromegaly

Sources:
51PubMed
See all sources

Articles related to Acromegaly:

(show top 50)    (show all 1327)
idTitleAuthorsYear
1
Computed tomographic signs of acromegaly in 68 diabetic cats with hypersomatotropism. (23847300)
2014
2
A consensus on the diagnosis and treatment of acromegaly complications. (22903574)
2013
3
Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature. (23291436)
2013
4
Is there any association between the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene and risk of colon polyp and abnormal glucose tolerance in acromegaly patients? (23368532)
2013
5
Acromegaly: Beyond surgery. (23961470)
2013
6
Growth hormone granulation pattern and somatostatin receptor subtype 2A correlate with postoperative somatostatin receptor ligand response in acromegaly: a large single center experience. (23184260)
2013
7
Treatments, complications, and healthcare utilization associated with acromegaly: a study in two large United States databases. (24037646)
2013
8
Aortic stiffness is increased in acromegaly regardless the method of assessment. (22082713)
2012
9
Effective combination treatment with cabergoline and low-dose pegvisomant in active acromegaly: a prospective clinical trial. (22278424)
2012
10
Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone. (21148630)
2011
11
ACTH response to desmopressin in a patient with acromegaly; expression of corticotropin-releasing factor, urocortins and vasopressin V1b receptor in GH-producing pituitary adenoma. (21908929)
2011
12
Effects of high-dose octreotide LAR on glucose metabolism in patients with acromegaly inadequately controlled by conventional somatostatin analog therapy. (21212103)
2011
13
Increased mammographic breast density in acromegaly: quantitative and qualitative assessment. (21156646)
2011
14
Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly. (20361261)
2011
15
Is left ventricular dysfunction reversed after treatment of active acromegaly? (20963505)
2011
16
A case of acromegaly (Greece, 7th century AD). (21868602)
2011
17
Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly. (20306022)
2010
18
The value of an acute octreotide suppression test in predicting response to long-term somatostatin analogue therapy in patients with acromegaly. (20393242)
2010
19
Short- and long-term efficacy of combined cabergoline and octreotide treatment in controlling igf-I levels in acromegaly. (20802256)
2010
20
Increased prevalence of acromegaly in a highly polluted area. (20621957)
2010
21
Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial. (20410233)
2010
22
Effects of somatostatin analogs on glucose homeostasis: a metaanalysis of acromegaly studies. (19208728)
2009
23
Pegvisomant improves insulin sensitivity and reduces overnight free fatty acid concentrations in patients with acromegaly. (19366854)
2009
24
No greater incidence or worsening of cardiac valve regurgitation with somatostatin analog treatment of acromegaly. (18381583)
2008
25
Lanreotide Autogel: a review of its use in the management of acromegaly. (18370450)
2008
26
Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study. (17218728)
2007
27
Treatment strategies for acromegaly. (16262568)
2005
28
Acromegaly due to a growth hormone-releasing hormone-secreting intracranial gangliocytoma. (15887863)
2005
29
Coexisting acromegaly and primary empty sella syndrome. (15361823)
2004
30
Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. (14671148)
2003
31
Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. (11134114)
2000
32
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. (10770982)
2000
33
A case of acromegaly accompanied by adrenal preclinical Cushing's syndrome. (10426577)
1999
34
Epidemiology of acromegaly. (11081170)
1999
35
Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly. (10595834)
1999
36
Treatment options for acromegaly. (8769385)
1996
37
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly. (7586626)
1995
38
Pharmacokinetics and efficacy of the long-acting somatostatin analogue somatuline in acromegaly. (7908838)
1994
39
A comparison of octreotide, bromocriptine, or a combination of both drugs in acromegaly. (8045964)
1994
40
CV 205-502 in acromegaly. (8100375)
1993
41
A marked molecular heterogeneity of growth hormone (GH) detected in the plasma but not pituitary of a patient with acromegaly: comparison with other acromegalics and an implication for discrepant plasma levels of GH and insulin-like growth factor. (1506622)
1992
42
Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. (1563080)
1992
43
Octreotide treatment of acromegaly. A randomized, multicenter study. (1416572)
1992
44
Effect of long-term treatment with somatostatin analogue (SMS 201-995) on pituitary tumor shrinkage in acromegaly--report of two cases. (1378566)
1992
45
High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of octreotide treatment. (1483295)
1992
46
Secretion of growth hormone-releasing hormone in patients with idiopathic pituitary dwarfism and acromegaly. (2898191)
1988
47
Treatment of acromegaly with a somatostatin analog in a patient with McCune-Albright syndrome. (2889819)
1987
48
Increase of serum growth hormone concentration following thyrotropin-releasing hormone injection in patients with acromegaly or gigantism. (4624350)
1972
49
The hypothalamus, brain-catecholamines, and drug therapy for gigantism and acromegaly. (4101619)
1971
50
A Singapore giant (gigantism with acromegaly): untreated with long survival. (5520865)
1970

Genetic Variations for Acromegaly

Expression for genes affiliated with Acromegaly

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acromegaly

Search GEO for disease gene expression data for Acromegaly.

Pathways for genes affiliated with Acromegaly

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Acromegaly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TRH, VIP, GNAS, TRHR, IGF1, SST
2
Hide members
10.6TRH, TRHR, SST, SSTR1, SSTR2, SSTR5
3
Hide members
10.5GHR, GHRH, GH1, PRL, IGF1
4
Hide members
10.5GAL, GHSR, SSTR5, SSTR2, SSTR1, TRHR
5
Hide members
10.5IGF1, PRL, GH1, GHR
6
Translation Insulin regulation of translation
Hide members
10.5IGF1, IGFBP3, GH1, GHR
7
Hide members
10.5VIP, GNAS, GHRHR, GHRH
810.5GHR, GH1, IGF1
9
Hide members
10.5PRL, GH1, GHR
1010.5TRHR, GHSR, GHR

Compounds for genes affiliated with Acromegaly

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Acromegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1acth4511.1VIP, PRL, SSTR5, SSTR2, SST, IGFBP3
2octreotide45 60 29 1114.1VIP, GNAS, GAL, GHR, GHSR, GHRH
3lanreotide45 2912.1SST, IGFBP3, IGF1, SSTR1, SSTR5, GHR
4gnrh4511.1VIP, GNAS, GAL, GHR, IGFBP3, IGF1
5ribonucleic acid4511.0PRL, GH1, GHRH, GHSR, GHR, GHRHR
6hexarelin45 2912.0IGF1, GH1, IGFBP3, GAL, GHRHR, GHR
7arginine4511.0GHRH, GHSR, GHR, GHRHR, GAL, GNAS
8ghrp4511.0GHRH, GHSR, GHR, GHRHR, TRH, PRL
9dopamine45 29 11 2414.0VIP, TRH, IGF1, SSTR1, SSTR2, SSTR5
10adenylate4511.0IGFBP3, SST, TRH, GNAS, SSTR2, GH1
11pyridostigmine45 1112.0GAL, GHRH, GH1, PRL, SST, IGFBP3
12clonidine45 29 1113.0GAL, GHR, GHRH, GH1, SST, IGFBP3
13thyroxine45 2412.0VIP, IGFBP3, GHRH, GH1, PRL, SST
14testosterone45 60 11 2414.0GAL, GH1, GHR, GHSR, PRL, VIP
15glucose4511.0TRH, IGF1, IGFBP3, SSTR2, GHRH, GAL
16levodopa45 1112.0GHR, PRL, SST, IGF1, TRH, GH1
17bromocriptine29 45 1113.0TRH, IGFBP3, VIP, GHR, GHRH, PRL
18thymidine45 2412.0MEN1, IGF1, GHR, GNAS, TRH, IGFBP3
19pegvisomant45 1112.0IGF1, IGFBP3, SST, GH1, GHRH, GHR
20cabergoline29 45 1112.9IGF1, IGFBP3, SST, GHR, GH1, PRL
21naloxone45 50 29 1113.9VIP, TRH, GAL, GHRH, GH1, PRL
22dexamethasone45 50 29 1113.9VIP, GHSR, GAL, GHRHR, GHRH, TRH
23triiodothyronine4510.9GHRH, GHR, GH1, PRL, IGFBP3, IGF1
24norepinephrine45 11 2412.9GAL, PRL, TRH, VIP, GHRH, GNAS
25estradiol45 11 2412.9GHSR, TRH, PRL, GHR, GHRH
26forskolin45 50 1112.9GAL, GHRHR, SSTR2, GHSR, GHRH
27quinagolide4510.9PRL, IGF1, SST, GH1
28atropine45 29 1112.9TRH, SST, GH1, GHRH, VIP, GAL
29pasireotide45 1111.9SSTR5, SSTR1, SST, SSTR2
30c-peptide4510.9GAL, GHR, IGF1, GH1, IGFBP3, SST
31naltrexone45 50 29 1113.9PRL, GH1, GHRH, IGFBP3, IGF1
32estrogen4510.9TRH
33cyclosomatostatin6010.8SST, SSTR1, SSTR5, SSTR2
34cyclic amp45 2411.8GHR, SSTR1, TRH, CNC, GHRH, GAL
35(1r,1s,3r/1r,1r,3s)-l-054,2646010.8SSTR5, SSTR2, SSTR1, SST
36cyn 1548066010.8SSTR5, SSTR1, SST, SSTR2
37progesterone45 60 29 11 2414.8TRH, SSTR2, IGF1, GNAS, IGFBP3, GHR
38cycloheximide4510.8TRH, TRHR, GHRH, GAL, GHR
39somatostatin60 2411.8SSTR2, SSTR1, SST, SSTR5
40vapreotide29 45 1112.8GHSR, SSTR5, SSTR2, SST
41111in-pentetreotide4510.8SST, SSTR1, SSTR2, SSTR5
42hydrocortisone45 2 60 1113.7PRL, SST, IGF1, TRH, GHSR, GH1
43dehydroepiandrosterone sulfate4510.7IGFBP3, IGF1, PRL, GH1, GHR
44tamoxifen45 50 29 1113.7PRL, IGFBP3, IGF1, GH1, GHRH, SSTR2
45dihydrotestosterone45 29 11 2413.7GH1, IGFBP3, GHR, VIP, IGF1, PRL
46leuprolide acetate4510.6GH1, IGF1, PRL, GHR
47serine4510.5GH1, GHRH, MEN1, GAL, GNAS, VIP
48acipimox45 2911.5IGF1, SST, GH1, GHRH
49buserelin45 29 1112.4SST, IGF1, IGFBP3, PRL
50glutamate4510.3SST, VIP, TRH, IGFBP3, GHRH, GHR

GO Terms for genes affiliated with Acromegaly

Sources:
16Gene Ontology
See all sources

Cellular components related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TRH, VIP, GNAS, GAL, GHR, GHRH
2extracellular spaceGO:00561510.6GHRH, GH1, SST, IGFBP3, IGF1, GHR
3secretory granuleGO:03014110.5GAL, GHRHR, PRL, TRH
4insulin-like growth factor binding protein complexGO:01694210.4IGF1, IGFBP3
5plasma membraneGO:00588610.3GNAS, GHRHR, GHR, GHSR, SSTR5, SSTR2

Biological processes related to Acromegaly according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, IGFBP3, GH1, GHRH, GHSR, GHRHR
2negative regulation of cell proliferationGO:00828510.9MEN1, SSTR5, SSTR2, SSTR1, SST, IGFBP3
3positive regulation of multicellular organism growthGO:04001810.9GHRHR, GHR, GHSR, GHRH, GH1
4growth hormone secretionGO:03025210.9GAL, GHRHR, GHSR, GHRH
5response to foodGO:03209410.9GHR, GHSR, GHRH
6response to nutrientGO:00758410.9SST, SSTR1, SSTR2, PRL
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9IGF1, GH1, GHR
8cell-cell signalingGO:00726710.8GHRH, SSTR2, SSTR1, SST, TRH
9hormone-mediated signaling pathwayGO:00975510.8GHR, GHSR, TRH
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PRL, GH1, GHR
11G-protein coupled receptor signaling pathwayGO:00718610.8VIP, GHSR, SSTR5, SST, TRHR
12regulation of multicellular organism growthGO:04001410.8GHR, PRL, IGF1
13positive regulation of cAMP biosynthetic processGO:03081910.8GHRH, GHRHR, GNAS
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8SSTR5, SSTR2, SSTR1
15water homeostasisGO:03010410.8IGF1, GHRHR
16digestionGO:00758610.7SSTR2, SSTR1, SST
17positive regulation of osteoblast differentiationGO:04566910.7IGF1, MEN1, GNAS
18cellular response to insulin stimulusGO:03286910.7GHRHR, GHR, GHSR
19response to estradiol stimulusGO:03235510.7PRL, GH1, GHR
20positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.7IGF1, GH1, GHR
21growth hormone receptor signaling pathwayGO:06039610.6GHR, GH1
22positive regulation of growth hormone secretionGO:06012410.6GHRHR, GHRH
23response to drugGO:04249310.5SST, PRL, GAL, GNAS
24cellular response to estradiol stimulusGO:07139210.5SSTR1, SSTR2
25positive regulation of JAK-STAT cascadeGO:04642710.4GH1, PRL
26insulin-like growth factor receptor signaling pathwayGO:04800910.2IGF1, GHR

Molecular functions related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6IGF1, SST, PRL, GH1, VIP
2somatostatin receptor activityGO:00499410.6SSTR1, SSTR2, SSTR5
3growth hormone-releasing hormone receptor activityGO:01652010.5GHSR, GHRHR
4neuropeptide hormone activityGO:00518410.5VIP, GAL, TRH
5peptide hormone bindingGO:01704610.4GHSR, GHR, GHRHR
6prolactin receptor bindingGO:00514810.2PRL, GH1

Products for genes affiliated with Acromegaly

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Sources for Acromegaly

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet