MCID: ACR007
MIFTS: 80

Acromegaly malady

Endocrine diseases, Cancer diseases categories

Summaries for Acromegaly

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (gh). it is most often diagnosed in middle-aged adults, although symptoms can appear at any age. signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. the condition is usually caused by benign tumors on the pituitary called adenomas. rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. when gh-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. last updated: 4/29/2011

MalaCards: Acromegaly, also known as infantile and juvenile forms of acromegaly, is related to adenoma and pituitary adenoma, and has symptoms including long/large ear, thick lips and long/large/bulbous nose. An important gene associated with Acromegaly is GNAS (GNAS complex locus), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs bromocriptine and octreotide and the compounds acth and octreotide have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Disease Ontology:8 A disease of metabolism that has material basis in excessive growth hormone production which results in enlargement located in limb.

Wikipedia:63 Acromegaly (/ˌækrɵˈmɛɡəli/; from Ancient Greek άκρος akros \"extreme\" or \"extremities\"... more...

Description from OMIM:46 102200

Aliases & Classifications for Acromegaly

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42NIH Rare Diseases, 8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
acromegaly:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acromegaly 8 9 42 46 10 44 48 60
infantile and juvenile forms of acromegaly 48
hypophyseal gigantism 48
growth hormone excess 42
somatotroph adenoma 42
pituitary gigantism 48
pituitary giant 42
gigantism 60


External Ids:

Disease Ontology8 DOID:2449
NCIt39 C84533
MeSH34 D000172
OMIM46 102200
MESH via Orphanet35 D000172, D005877
ICD10 via Orphanet26 E22.0
SNOMED-CT via Orphanet57 74107003, 80849007
UMLS via Orphanet61 C0001206, C0017547

Related Diseases for Acromegaly

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17GeneCards, 18GeneDecks
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Diseases related to Acromegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 363)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0GNAS, GAL, CNC, MEN1, GHRHR, GHR
2pituitary adenoma30.9MEN1, GHRHR, GHR, GHSR, GHRH, GH1
3pituitary apoplexy30.8PRL, TRH
4mccune albright syndrome30.7GNAS, GH1, PRL
5diabetes mellitus30.6GHR, GH1, SST, IGFBP3, IGF1
6thyroiditis30.5TRH
7prolactinoma30.5GNAS, GAL, MEN1, GHRHR, GHSR, GH1
8pancreatitis30.4SST
9hyperprolactinemia30.4PRL, SST, IGF1, TRH, GH1, VIP
10fibrous dysplasia30.3GH1, GHR, GNAS
11hypopituitarism30.3IGF1, TRH, IGFBP3, SST, PRL, GHR
12neuroendocrine tumor30.3VIP, GNAS, GAL, MEN1, GHSR, GH1
13cushing's syndrome30.3GH1, SST
14hypertension30.2IGF1
15amenorrhea30.2PRL, IGF1, TRH
16dwarfism30.1GHRHR, GHR, GHRH, GH1, IGFBP3, IGF1
17empty sella syndrome30.1PRL, TRH
18atherosclerosis30.1GHSR, IGF1
19hyperparathyroidism30.0MEN1
20carney complex30.0AIP, MEN1, GNAS
21goiter30.0GNAS, TRH
22hepatitis30.0GHR, GAL
23acanthosis nigricans30.0IGF1
24glucose intolerance30.0GH1, IGFBP3, IGF1
25thyroid cancer30.0GNAS, GHSR, TRH
26hypoglycemia29.9GAL, GHR, GHRH, GH1, PRL, SST
27hypothyroidism29.9TRH, GNAS, GHRHR, GHR, GHSR, GHRH
28hypogonadism29.9TRH, IGF1, IGFBP3, PRL, GH1
29panhypopituitarism29.9GHR, GH1, PRL, IGF1
30diabetes insipidus29.9GHRH, PRL, TRH
31zollinger-ellison syndrome29.9SST, GHRH, MEN1
32proliferative diabetic retinopathy29.9GHR, SST, IGFBP3, IGF1
33leukemia29.9GHR, MEN1, GAL
34arthritis29.9GAL, VIP
35chromophobe adenoma29.9GH1, PRL
36neurofibromatosis29.9SST, GHR, MEN1
37nelson syndrome29.9PRL, SST
38sarcoma29.9SSTR2
39diabetic retinopathy29.9IGF1
40ovarian cyst29.9GNAS, CNC
41myopathy29.9IGF1
42thyroid medullary carcinoma29.7MEN1, SSTR5, SSTR2, SSTR1, SST
43melanoma29.7SSTR2, GHR, GAL
44cholera29.7VIP, GNAS, GAL, TRH
45hyperthyroidism29.7GNAS, GAL, GHR, GHRH, GH1, PRL
46breast cancer29.7GHSR, GHRHR, MEN1, GAL, VIP, GHRH
47obesity29.7GNAS, GAL, GHR, GHSR, TRH, IGF1
48hyperglycemia29.7GAL, GHR, GHSR, GHRH, GH1, SST
49gigantism29.7AIP, IGF1, SST, PRL, GNAS, GH1
50pheochromocytoma29.7VIP, GNAS, GAL, MEN1, SSTR5, SSTR2

Graphical network of the top 20 diseases related to Acromegaly:



Diseases related to acromegaly

Clinical Features for Acromegaly

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46OMIM, 48Orphanet
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Clinical features from OMIM:

102200

Symptoms:

48 (show all 19)
  • long/large ear
  • thick lips
  • long/large/bulbous nose
  • macroglossia/tongue protrusion/proeminent/hypertrophic
  • prognathism/prognathia
  • long face
  • coarse face
  • large hand
  • tapered fingers
  • macropenis/megapenis/large penis
  • hirsutism/hypertrichosis/increased body hair
  • kyphosis
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • synophris/synophrys
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • tall stature/gigantism/growth acceleration
  • autosomal dominant inheritance
  • enlarged diaphysis/diaphyses
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism

Drugs & Therapeutics for Acromegaly

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acromegaly

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Anatomical Context for Acromegaly

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Acromegaly:

32
Pituitary, Bone, Testes, Brain, Pancreas, Lung, Thyroid, Colon, Heart, Endothelial, Tongue, Skin, Liver, Ovary, Prostate, Myeloid, Skeletal muscle, Kidney, Breast, Cervix, Pancreatic islet, Uterus, Spinal cord, Hypothalamus, Adipocyte, Tonsil

FMA organs/tissues related to Acromegaly:

14
Limb

Animal Models for Acromegaly or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acromegaly:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9TRH, GHRH, GHSR, GHR, GHRHR, MEN1
2MP:000537810.8GHSR, GHR, GHRHR, MEN1, GAL, GNAS
3MP:000537910.7GAL, MEN1, GHRHR, GHR, GHRH, SSTR5
4MP:000363110.7GNAS, GAL, MEN1, GHRHR, GHR, GHRH
5MP:000538610.7GHR, GHRHR, GAL, GNAS, VIP, GHSR
6MP:000538710.6GNAS, MEN1, GHRHR, GHR, GHRH, PRL
7MP:000538910.6VIP, GAL, MEN1, GHRHR, GHR, GHRH
8MP:000537510.5GNAS, GHRHR, GHR, GHSR, GH1, IGFBP3
9MP:000537010.3GNAS, MEN1, GHR, GHRH, GH1, PRL

Publications for Acromegaly

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50PubMed
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Articles related to Acromegaly:

(show top 50)    (show all 1327)
idTitleAuthorsYear
1
Prevalence and risk factors of impaired glucose tolerance and diabetes mellitus at diagnosis of acromegaly: a study in 148 patients. (23446424)
2014
2
Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naA^ve acromegaly. (23593161)
2013
3
Biochemical and quality of life responses to octreotide-LAR in acromegaly. (24178448)
2013
4
Comparison of the effects of primary somatostatin analogue therapy and pituitary adenomectomy on survival in patients with acromegaly: a retrospective cohort study. (23828855)
2013
5
Magnification of Growth Hormone-Secreting Tumor Cells: Could Electron Microscopy Be a New Paradigm for Outcome in Acromegaly? (23454179)
2013
6
Predictors of endoscopic transsphenoidal surgery outcome in acromegaly: patient and tumor characteristics evaluated by magnetic resonance imaging. (22535510)
2013
7
Preoperative lanreotide treatment improves outcome in patients with acromegaly resulting from invasive pituitary macroadenoma. (22613412)
2012
8
Risk of neoplasms in acromegaly. (23788865)
2012
9
Severe hypocalcemia complicated by postsurgical hypoparathyroidism and hungry bone syndrome in a patient with primary hyperparathyroidism, Graves' disease, and acromegaly. (22821103)
2012
10
Pharmacotherapy: Somatoprim versus octreotide in acromegaly. (22124440)
2012
11
Glucose homeostasis in patients with acromegaly treated with surgery or somatostatin analogues. (21521267)
2011
12
Increased rate of intracranial saccular aneurysms in acromegaly: an MR angiography study and review of the literature. (21307138)
2011
13
Gammaknife radiosurgery in patients with acromegaly. (22001240)
2011
14
Adrenal lesions in acromegaly: there is a role of metabolic aspects and AIP (Aryl Hydrocarbon Receptor Interacting Protein) gene? Evaluation at baseline and after long term follow-up. (20595802)
2010
15
Aberrations in carbohydrate metabolism in patients with diagnosed acromegaly, hospitalized in the Endocrinology and Diabetology Department of Collegium Medicum University of Nicolaus Copernicus in Bydgoszcz in the years 2001-2009. (20602299)
2010
16
Optimizing acromegaly treatment. (20616509)
2010
17
Interferon-I^ treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis. (20873969)
2010
18
Female gonadal function before and after treatment of acromegaly. (20660045)
2010
19
Cost-effectiveness of lanreotide Autogel in treatment algorithms of acromegaly. (19527094)
2009
20
Remission of acromegaly following long-term therapy with cabergoline: report of two cases. (17530416)
2008
21
The role of pegvisomant in the treatment of acromegaly. (18407771)
2008
22
Clinical and biochemical improvement in acromegaly during pregnancy. (18401209)
2008
23
Consensus statement of the Polish Society for Endocrinology: presurgical somatostatin analogs therapy in acromegaly. (18283267)
2008
24
Gamma knife radiosurgery for acromegaly--long-term experience. (16649981)
2006
25
Decrease in serum ghrelin levels in patients with acromegaly normalize after successful surgical treatment]. (16821203)
2005
26
Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly. (15613435)
2005
27
Pegvisomant: a novel pharmacotherapy for the treatment of acromegaly. (15006735)
2004
28
Lessons from 6 years of GH receptor antagonist therapy for acromegaly. (15497659)
2003
29
Improvement of acromegaly after octreotide LAR treatment. (14674721)
2003
30
Filter paper collection of plasma for IGF-I test in patients with acromegaly. (12175092)
2002
31
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. (12372843)
2002
32
Diagnostic value of the acid-labile subunit in acromegaly: evaluation in comparison with insulin-like growth factor (IGF) I, and IGF-binding protein-1, -2, and -3. (11238491)
2001
33
Menstrual irregularity in women with acromegaly. (10443669)
1999
34
New medical treatment for acromegaly. (11081177)
1999
35
Slow-release lanreotide treatment in acromegaly: effects on quality of life. (10224516)
1999
36
Acromegaly in a woman presenting with diabetic ketoacidosis and insulin resistance. (9536592)
1997
37
Acromegaly: the significance of serum total and free IGF-I and IGF-binding protein-3 in diagnosis. (9389990)
1997
38
Elevated fibrinogen levels decrease following treatment of acromegaly. (9059560)
1997
39
Body composition in active acromegaly during treatment with octreotide: a double-blind, placebo-controlled cross-over study. (7955439)
1994
40
Octreotide long term treatment of acromegaly: effect of drug withdrawal on serum growth hormone/insulin-like growth factor-I concentrations and on serum gastrin/24-hour intragastric pH values. (8325938)
1993
41
Insulin secretion and insulin-like growth factor-I levels in active and controlled acromegaly. (1559300)
1992
42
Diagnosis and endocrine testing in acromegaly. (1521517)
1992
43
Bromocriptine treatment over 12 years in acromegaly: effect on growth hormone and prolactin secretion. (1574954)
1992
44
Octreotide stimulates insulin-like growth factor binding protein-1 (IGFBP-1) levels in acromegaly. (1713220)
1991
45
Acromegaly, multinodular goiter and silent polyostotic fibrous dysplasia. A variant of the McCune-Albright syndrome. (2273209)
1990
46
Treatment of acromegaly with the long-acting somatostatin analog SMS 201-995. (2891720)
1988
47
A comparison among the growth hormone-lowering effects in acromegaly of the somatostatin analog SMS 201-995, bromocriptine, and the combination of both drugs. (2872225)
1986
48
Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age. (675127)
1978
49
Hypothalamic hypopituitarism after pituitary apoplexy in acromegaly. (197898)
1977
50
Insulin deficiency associated with hypoglycemia and good glucose tolerance in hypopituitarism. Report of a case with acromegaly developing pituitary apoplexy. (4830062)
1974

Genetic Variations for Acromegaly

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Expression for genes affiliated with Acromegaly

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acromegaly

Search GEO for disease gene expression data for Acromegaly.

Pathways for genes affiliated with Acromegaly

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Acromegaly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TRH, VIP, GNAS, TRHR, IGF1, SST
2
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10.6TRH, TRHR, SST, SSTR1, SSTR2, SSTR5
3
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10.5GHR, GHRH, GH1, PRL, IGF1
4
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10.5IGF1, PRL, GH1, GHR
5
Translation Insulin regulation of translation
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10.5IGF1, IGFBP3, GH1, GHR
6
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10.5GAL, GHSR, SSTR5, SSTR2, SSTR1, TRHR
7
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10.5VIP, GNAS, GHRHR, GHRH
810.5GHR, GH1, IGF1
9
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10.5PRL, GH1, GHR
1010.5TRHR, GHSR, GHR

Compounds for genes affiliated with Acromegaly

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Acromegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1acth4411.1VIP, PRL, SSTR5, SSTR2, SST, IGFBP3
2octreotide44 59 28 1114.1VIP, GNAS, GAL, GHR, GHSR, GHRH
3gnrh4411.1VIP, GNAS, GAL, GHR, IGFBP3, IGF1
4lanreotide44 2812.1SST, IGFBP3, IGF1, SSTR1, SSTR5, GHR
5hexarelin44 2812.0IGF1, GH1, IGFBP3, GAL, GHRHR, GHR
6ribonucleic acid4411.0PRL, GH1, GHRH, GHSR, GHR, GHRHR
7arginine4411.0GHRH, GHSR, GHR, GHRHR, GAL, GNAS
8ghrp4411.0GHRH, GHSR, GHR, GHRHR, TRH, PRL
9dopamine44 28 11 2414.0VIP, TRH, IGF1, SSTR1, SSTR2, SSTR5
10adenylate4411.0IGFBP3, SST, TRH, GNAS, SSTR2, GH1
11pyridostigmine44 1112.0GAL, GHRH, GH1, PRL, SST, IGFBP3
12clonidine44 28 1113.0GAL, GHR, GHRH, GH1, SST, IGFBP3
13thyroxine44 2412.0VIP, IGFBP3, GHRH, GH1, PRL, SST
14testosterone44 59 11 2414.0GAL, GH1, GHR, GHSR, PRL, VIP
15levodopa44 1112.0GHR, PRL, SST, IGF1, TRH, GH1
16glucose4411.0TRH, IGF1, IGFBP3, SSTR2, GHRH, GAL
17bromocriptine28 44 1113.0TRH, IGFBP3, VIP, GHR, GHRH, PRL
18pegvisomant44 1112.0IGF1, IGFBP3, SST, GH1, GHRH, GHR
19thymidine44 2412.0MEN1, IGF1, GHR, GNAS, TRH, IGFBP3
20cabergoline28 44 1112.9IGF1, IGFBP3, SST, GHR, GH1, PRL
21naloxone44 49 28 1113.9VIP, TRH, GAL, GHRH, GH1, PRL
22dexamethasone44 49 28 1113.9VIP, GHSR, GAL, GHRHR, GHRH, TRH
23triiodothyronine4410.9GHRH, GHR, GH1, PRL, IGFBP3, IGF1
24norepinephrine44 11 2412.9GAL, PRL, TRH, VIP, GHRH, GNAS
25estradiol44 11 2412.9GHSR, TRH, PRL, GHR, GHRH
26forskolin44 49 1112.9GAL, GHRHR, SSTR2, GHSR, GHRH
27quinagolide4410.9PRL, IGF1, SST, GH1
28atropine44 28 1112.9TRH, SST, GH1, GHRH, VIP, GAL
29c-peptide4410.9GAL, GHR, IGF1, GH1, IGFBP3, SST
30naltrexone44 49 28 1113.9PRL, GH1, GHRH, IGFBP3, IGF1
31pasireotide44 1111.9SSTR5, SSTR1, SST, SSTR2
32estrogen4410.9TRH
33cyclic amp44 2411.8GHR, SSTR1, TRH, CNC, GHRH, GAL
34cyclosomatostatin5910.8SST, SSTR1, SSTR5, SSTR2
35(1r,1s,3r/1r,1r,3s)-l-054,2645910.8SSTR5, SSTR2, SSTR1, SST
36cyn 1548065910.8SSTR5, SSTR1, SST, SSTR2
37progesterone44 59 28 11 2414.8TRH, SSTR2, IGF1, GNAS, IGFBP3, GHR
38cycloheximide4410.8TRH, TRHR, GHRH, GAL, GHR
39somatostatin59 2411.8SSTR2, SSTR1, SST, SSTR5
40vapreotide28 44 1112.8GHSR, SSTR5, SSTR2, SST
41111in-pentetreotide4410.8SST, SSTR1, SSTR2, SSTR5
42hydrocortisone44 2 59 1113.7PRL, SST, IGF1, TRH, GHSR, GH1
43dehydroepiandrosterone sulfate4410.7IGFBP3, IGF1, PRL, GH1, GHR
44tamoxifen44 49 28 1113.7PRL, IGFBP3, IGF1, GH1, GHRH, SSTR2
45dihydrotestosterone44 28 11 2413.7GH1, IGFBP3, GHR, VIP, IGF1, PRL
46leuprolide acetate4410.6GH1, IGF1, PRL, GHR
47serine4410.5GH1, GHRH, MEN1, GAL, GNAS, VIP
48acipimox44 2811.5IGF1, SST, GH1, GHRH
49buserelin44 28 1112.4SST, IGF1, IGFBP3, PRL
50glutamate4410.3SST, VIP, TRH, IGFBP3, GHRH, GHR

GO Terms for genes affiliated with Acromegaly

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16Gene Ontology
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Cellular components related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TRH, VIP, GNAS, GAL, GHR, GHRH
2extracellular spaceGO:00561510.6GHRH, GH1, SST, IGFBP3, IGF1, GHR
3secretory granuleGO:03014110.5GAL, GHRHR, PRL, TRH
4insulin-like growth factor binding protein complexGO:01694210.4IGF1, IGFBP3
5plasma membraneGO:00588610.3GNAS, GHRHR, GHR, GHSR, SSTR5, SSTR2

Biological processes related to Acromegaly according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, IGFBP3, GH1, GHRH, GHSR, GHRHR
2positive regulation of multicellular organism growthGO:04001810.9GHRHR, GHR, GHSR, GHRH, GH1
3negative regulation of cell proliferationGO:00828510.9MEN1, SSTR5, SSTR2, SSTR1, SST, IGFBP3
4growth hormone secretionGO:03025210.9GAL, GHRHR, GHSR, GHRH
5response to foodGO:03209410.9GHR, GHSR, GHRH
6response to nutrientGO:00758410.9SST, SSTR1, SSTR2, PRL
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9IGF1, GH1, GHR
8cell-cell signalingGO:00726710.8GHRH, SSTR2, SSTR1, SST, TRH
9hormone-mediated signaling pathwayGO:00975510.8GHR, GHSR, TRH
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PRL, GH1, GHR
11G-protein coupled receptor signaling pathwayGO:00718610.8VIP, GHSR, SSTR5, SST, TRHR
12regulation of multicellular organism growthGO:04001410.8GHR, PRL, IGF1
13positive regulation of cAMP biosynthetic processGO:03081910.8GHRH, GHRHR, GNAS
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8SSTR5, SSTR2, SSTR1
15water homeostasisGO:03010410.8IGF1, GHRHR
16digestionGO:00758610.7SSTR2, SSTR1, SST
17positive regulation of osteoblast differentiationGO:04566910.7IGF1, MEN1, GNAS
18cellular response to insulin stimulusGO:03286910.7GHRHR, GHR, GHSR
19response to estradiol stimulusGO:03235510.7PRL, GH1, GHR
20positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.7IGF1, GH1, GHR
21growth hormone receptor signaling pathwayGO:06039610.6GHR, GH1
22positive regulation of growth hormone secretionGO:06012410.6GHRHR, GHRH
23response to drugGO:04249310.5SST, PRL, GAL, GNAS
24cellular response to estradiol stimulusGO:07139210.5SSTR1, SSTR2
25positive regulation of JAK-STAT cascadeGO:04642710.4GH1, PRL
26insulin-like growth factor receptor signaling pathwayGO:04800910.2IGF1, GHR

Molecular functions related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7IGF1, SST, PRL, GH1, VIP
2somatostatin receptor activityGO:00499410.6SSTR1, SSTR2, SSTR5
3growth hormone-releasing hormone receptor activityGO:01652010.5GHSR, GHRHR
4neuropeptide hormone activityGO:00518410.5VIP, GAL, TRH
5peptide hormone bindingGO:01704610.4GHSR, GHR, GHRHR
6prolactin receptor bindingGO:00514810.2PRL, GH1

Products for genes affiliated with Acromegaly

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Sources for Acromegaly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet