MCID: ACR007
MIFTS: 80

Acromegaly malady

Endocrine diseases, Cancer diseases categories

Summaries for Acromegaly

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (gh). it is most often diagnosed in middle-aged adults, although symptoms can appear at any age. signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. the condition is usually caused by benign tumors on the pituitary called adenomas. rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. when gh-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. last updated: 4/29/2011

MalaCards: Acromegaly, also known as infantile and juvenile forms of acromegaly, is related to adenoma and pituitary adenoma, and has symptoms including long/large ear, thick lips and long/large/bulbous nose. An important gene associated with Acromegaly is GNAS (GNAS complex locus), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs bromocriptine and octreotide and the compounds acth and octreotide have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Disease Ontology:8 A disease of metabolism that has material basis in excessive growth hormone production which results in enlargement located in limb.

Wikipedia:63 Acromegaly (/ˌækrɵˈmɛɡəli/; from Ancient Greek άκρος akros \"extreme\" or \"extremities\"... more...

Description from OMIM:46 102200

Aliases & Classifications for Acromegaly

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42NIH Rare Diseases, 8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
acromegaly:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acromegaly 8 9 42 46 10 44 48 60
infantile and juvenile forms of acromegaly 48
hypophyseal gigantism 48
growth hormone excess 42
somatotroph adenoma 42
pituitary gigantism 48
pituitary giant 42
gigantism 60


External Ids:

Disease Ontology8 DOID:2449
NCIt39 C84533
MeSH34 D000172
OMIM46 102200
MESH via Orphanet35 D000172, D005877
ICD10 via Orphanet26 E22.0
SNOMED-CT via Orphanet57 74107003, 80849007
UMLS via Orphanet61 C0001206, C0017547

Related Diseases for Acromegaly

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17GeneCards, 18GeneDecks
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Diseases related to Acromegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 363)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0GNAS, GAL, CNC, MEN1, GHRHR, GHR
2pituitary adenoma30.9MEN1, GHRHR, GHR, GHSR, GHRH, GH1
3pituitary apoplexy30.8PRL, TRH
4mccune albright syndrome30.7GNAS, GH1, PRL
5diabetes mellitus30.6GHR, GH1, SST, IGFBP3, IGF1
6thyroiditis30.5TRH
7prolactinoma30.5GNAS, GAL, MEN1, GHRHR, GHSR, GH1
8pancreatitis30.4SST
9hyperprolactinemia30.4PRL, SST, IGF1, TRH, GH1, VIP
10fibrous dysplasia30.3GH1, GHR, GNAS
11hypopituitarism30.3IGF1, TRH, IGFBP3, SST, PRL, GHR
12neuroendocrine tumor30.3VIP, GNAS, GAL, MEN1, GHSR, GH1
13cushing's syndrome30.3GH1, SST
14hypertension30.2IGF1
15amenorrhea30.2PRL, IGF1, TRH
16dwarfism30.1GHRHR, GHR, GHRH, GH1, IGFBP3, IGF1
17empty sella syndrome30.1PRL, TRH
18atherosclerosis30.1GHSR, IGF1
19hyperparathyroidism30.0MEN1
20carney complex30.0AIP, MEN1, GNAS
21goiter30.0GNAS, TRH
22hepatitis30.0GHR, GAL
23acanthosis nigricans30.0IGF1
24glucose intolerance30.0GH1, IGFBP3, IGF1
25thyroid cancer30.0GNAS, GHSR, TRH
26hypoglycemia29.9GAL, GHR, GHRH, GH1, PRL, SST
27hypothyroidism29.9TRH, GNAS, GHRHR, GHR, GHSR, GHRH
28hypogonadism29.9TRH, IGF1, IGFBP3, PRL, GH1
29panhypopituitarism29.9GHR, GH1, PRL, IGF1
30diabetes insipidus29.9GHRH, PRL, TRH
31zollinger-ellison syndrome29.9SST, GHRH, MEN1
32proliferative diabetic retinopathy29.9GHR, SST, IGFBP3, IGF1
33leukemia29.9GHR, MEN1, GAL
34arthritis29.9GAL, VIP
35chromophobe adenoma29.9GH1, PRL
36neurofibromatosis29.9SST, GHR, MEN1
37nelson syndrome29.9PRL, SST
38sarcoma29.9SSTR2
39diabetic retinopathy29.9IGF1
40ovarian cyst29.9GNAS, CNC
41myopathy29.9IGF1
42thyroid medullary carcinoma29.7MEN1, SSTR5, SSTR2, SSTR1, SST
43melanoma29.7SSTR2, GHR, GAL
44cholera29.7VIP, GNAS, GAL, TRH
45hyperthyroidism29.7GNAS, GAL, GHR, GHRH, GH1, PRL
46breast cancer29.7GHSR, GHRHR, MEN1, GAL, VIP, GHRH
47obesity29.7GNAS, GAL, GHR, GHSR, TRH, IGF1
48hyperglycemia29.7GAL, GHR, GHSR, GHRH, GH1, SST
49gigantism29.7AIP, IGF1, SST, PRL, GNAS, GH1
50pheochromocytoma29.7VIP, GNAS, GAL, MEN1, SSTR5, SSTR2

Graphical network of the top 20 diseases related to Acromegaly:



Diseases related to acromegaly

Clinical Features for Acromegaly

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46OMIM, 48Orphanet
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Clinical features from OMIM:

102200

Symptoms:

48 (show all 19)
  • long/large ear
  • thick lips
  • long/large/bulbous nose
  • macroglossia/tongue protrusion/proeminent/hypertrophic
  • prognathism/prognathia
  • long face
  • coarse face
  • large hand
  • tapered fingers
  • macropenis/megapenis/large penis
  • hirsutism/hypertrichosis/increased body hair
  • kyphosis
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • synophris/synophrys
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • tall stature/gigantism/growth acceleration
  • autosomal dominant inheritance
  • enlarged diaphysis/diaphyses
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism

Drugs & Therapeutics for Acromegaly

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acromegaly

Drug clinical trials:

Search ClinicalTrials for Acromegaly

Search NIH Clinical Center for Acromegaly

Search CenterWatch for Acromegaly

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acromegaly

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Anatomical Context for Acromegaly

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Acromegaly:

32
Pituitary, Bone, Testes, Brain, Pancreas, Lung, Thyroid, Colon, Heart, Endothelial, Tongue, Skin, Liver, Ovary, Prostate, Myeloid, Skeletal muscle, Kidney, Breast, Cervix, Pancreatic islet, Uterus, Spinal cord, Hypothalamus, Adipocyte, Tonsil

FMA organs/tissues related to Acromegaly:

14
Limb

Animal Models for Acromegaly or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acromegaly:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9TRH, GHRH, GHSR, GHR, GHRHR, MEN1
2MP:000537810.8GHSR, GHR, GHRHR, MEN1, GAL, GNAS
3MP:000537910.7GAL, MEN1, GHRHR, GHR, GHRH, SSTR5
4MP:000363110.7GNAS, GAL, MEN1, GHRHR, GHR, GHRH
5MP:000538610.7GHR, GHRHR, GAL, GNAS, VIP, GHSR
6MP:000538710.6GNAS, MEN1, GHRHR, GHR, GHRH, PRL
7MP:000538910.6VIP, GAL, MEN1, GHRHR, GHR, GHRH
8MP:000537510.5GNAS, GHRHR, GHR, GHSR, GH1, IGFBP3
9MP:000537010.3GNAS, MEN1, GHR, GHRH, GH1, PRL

Publications for Acromegaly

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50PubMed
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Articles related to Acromegaly:

(show top 50)    (show all 1327)
idTitleAuthorsYear
1
Lanreotide extended-release aqueous-gel formulation, injected by patient, partner or healthcare provider in patients with acromegaly in the United States: 1-year data from the SODA registry. (23314980)
2014
2
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
3
Endoscopic vs microsurgical transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission. (23737543)
2013
4
Determination of nadir growth hormone concentration cutoff in patients with acromegaly. (23807518)
2013
5
Emerging drugs for acromegaly. (24400774)
2013
6
Treatment of acromegaly by endoscopic transsphenoidal surgery: surgical experience in 214 cases and cure rates according to current consensus criteria. (24074496)
2013
7
Ossified ligamentum flavum causing spinal cord compression in a patient with acromegaly. (23706185)
2013
8
Organohalogenated contaminants in domestic cats' plasma in relation to spontaneous acromegaly and type 2 diabetes mellitus: a clue for endocrine disruption in humans? (23672960)
2013
9
Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature. (21960210)
2012
10
CT and MRI evaluation of skull bones and soft tissues in six cats with presumed acromegaly versus 12 unaffected cats. (22703122)
2012
11
Colonic neoplasia in acromegaly: increased proliferation or deceased apoptosis? (21451936)
2012
12
Pamidronic acid and cabergoline as effective long-term therapy in a 12-year-old girl with extended facial polyostotic fibrous dysplasia, prolactinoma and acromegaly in McCune-Albright syndrome: a case report. (22273876)
2012
13
Octreotide long-acting repeatable for acromegaly. (22390555)
2012
14
Acromegaly without acral changes: A rare presentation. (22629521)
2012
15
Prevalence of antipituitary antibodies in acromegaly. (22002711)
2012
16
Population pharmacokinetic and pharmacodynamic modeling of pegvisomant in asian and Western acromegaly patients. (21209237)
2011
17
Primary treatment of acromegaly with high-dose lanreotide: a case series. (20211008)
2010
18
Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly. (19494714)
2009
19
Clinical use of cabergoline as primary and adjunctive treatment for acromegaly. (18708434)
2008
20
Acromegaly: new principles for treatment]. (17359733)
2007
21
Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly. (17895318)
2007
22
The importance of presurgical somatostatin analogue therapy in acromegaly. (18058729)
2007
23
Fibroblast growth factor (FGF)23 in patients with acromegaly. (17457012)
2007
24
A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. (15827109)
2005
25
Acromegaly in a multiple endocrine neoplasia type 1 (MEN1) family with low penetrance of the disease. (16322378)
2005
26
Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegaly. (16003295)
2005
27
Gamma-knife surgery is effective in normalising plasma insulin-like growth factor I in patients with acromegaly. (15891958)
2005
28
Modulation of cortisol metabolism during treatment of acromegaly is independent of body composition and insulin sensitivity. (15004437)
2004
29
The place of pegvisomant in the acromegaly treatment algorithm. (15135788)
2004
30
Men with acromegaly need higher doses of octreotide than women. (11849249)
2002
31
Optimizing somatostatin analog therapy in acromegaly: long-acting formulations. (15799207)
2002
32
Successful treatment of resistant acromegaly with a growth hormone receptor antagonist. (11581004)
2001
33
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly. (11453963)
2001
34
Combined therapy of acromegaly with a combination of lanreotide and terguride]. (11191748)
2000
35
Pharmacotherapy or surgery as primary treatment for acromegaly? (10984197)
2000
36
Octreotide suppresses the incretin glucagon-like peptide (7-36) amide in patients with acromegaly or clinically nonfunctioning pituitary tumors and in healthy subjects. (10377503)
1999
37
Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6. (9579239)
1998
38
Sleep apnoea in treated acromegaly: relative frequency and predisposing factors. (8977753)
1996
39
Relationship between fasting glycemia, serum peptide C, insulin, growth hormone and plasma glucagon in acromegaly]. (9005421)
1996
40
Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly. (7593436)
1995
41
Acromegaly. Recognition and treatment. (7514973)
1994
42
Bromocriptine treatment over 12 years in acromegaly: effect on glucose tolerance and insulin secretion. (8508007)
1993
43
Growth hormone and insulin-like growth factor-1 in blood and urine as response markers during treatment of acromegaly with octreotide: a double-blind placebo-controlled study. (8514980)
1993
44
Somatostatin analogs in the treatment of acromegaly. (1355729)
1992
45
Resistance to a long-acting somatostatin analog (SMS 201-995) reversed by surgery in acromegaly. (2273211)
1990
46
Insulin secretion and sensitivity in acromegaly. (2193770)
1990
47
Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201-995: shrinkage of invasive pituitary macroadenomas and improved surgical remission rate. (2903168)
1988
48
Acromegaly after pituitary apoplexy. (3560376)
1987
49
Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly. (747897)
1978
50
Pituitary apoplexy in acromegaly. (4880887)
1968

Genetic Variations for Acromegaly

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Expression for genes affiliated with Acromegaly

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acromegaly

Search GEO for disease gene expression data for Acromegaly.

Pathways for genes affiliated with Acromegaly

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Acromegaly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TRH, VIP, GNAS, TRHR, IGF1, SST
2
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10.6TRH, TRHR, SST, SSTR1, SSTR2, SSTR5
3
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10.5GHR, GHRH, GH1, PRL, IGF1
4
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10.5IGF1, PRL, GH1, GHR
5
Translation Insulin regulation of translation
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10.5IGF1, IGFBP3, GH1, GHR
6
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10.5GAL, GHSR, SSTR5, SSTR2, SSTR1, TRHR
7
Hide members
10.5VIP, GNAS, GHRHR, GHRH
810.5GHR, GH1, IGF1
9
Hide members
10.5PRL, GH1, GHR
1010.5TRHR, GHSR, GHR

Compounds for genes affiliated with Acromegaly

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Acromegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1acth4411.1VIP, PRL, SSTR5, SSTR2, SST, IGFBP3
2octreotide44 59 28 1114.1VIP, GNAS, GAL, GHR, GHSR, GHRH
3gnrh4411.1VIP, GNAS, GAL, GHR, IGFBP3, IGF1
4lanreotide44 2812.1SST, IGFBP3, IGF1, SSTR1, SSTR5, GHR
5hexarelin44 2812.0IGF1, GH1, IGFBP3, GAL, GHRHR, GHR
6ribonucleic acid4411.0PRL, GH1, GHRH, GHSR, GHR, GHRHR
7arginine4411.0GHRH, GHSR, GHR, GHRHR, GAL, GNAS
8ghrp4411.0GHRH, GHSR, GHR, GHRHR, TRH, PRL
9dopamine44 28 11 2414.0VIP, TRH, IGF1, SSTR1, SSTR2, SSTR5
10adenylate4411.0IGFBP3, SST, TRH, GNAS, SSTR2, GH1
11pyridostigmine44 1112.0GAL, GHRH, GH1, PRL, SST, IGFBP3
12clonidine44 28 1113.0GAL, GHR, GHRH, GH1, SST, IGFBP3
13thyroxine44 2412.0VIP, IGFBP3, GHRH, GH1, PRL, SST
14testosterone44 59 11 2414.0GAL, GH1, GHR, GHSR, PRL, VIP
15levodopa44 1112.0GHR, PRL, SST, IGF1, TRH, GH1
16glucose4411.0TRH, IGF1, IGFBP3, SSTR2, GHRH, GAL
17bromocriptine28 44 1113.0TRH, IGFBP3, VIP, GHR, GHRH, PRL
18pegvisomant44 1112.0IGF1, IGFBP3, SST, GH1, GHRH, GHR
19thymidine44 2412.0MEN1, IGF1, GHR, GNAS, TRH, IGFBP3
20cabergoline28 44 1112.9IGF1, IGFBP3, SST, GHR, GH1, PRL
21naloxone44 49 28 1113.9VIP, TRH, GAL, GHRH, GH1, PRL
22dexamethasone44 49 28 1113.9VIP, GHSR, GAL, GHRHR, GHRH, TRH
23triiodothyronine4410.9GHRH, GHR, GH1, PRL, IGFBP3, IGF1
24norepinephrine44 11 2412.9GAL, PRL, TRH, VIP, GHRH, GNAS
25estradiol44 11 2412.9GHSR, TRH, PRL, GHR, GHRH
26forskolin44 49 1112.9GAL, GHRHR, SSTR2, GHSR, GHRH
27quinagolide4410.9PRL, IGF1, SST, GH1
28atropine44 28 1112.9TRH, SST, GH1, GHRH, VIP, GAL
29c-peptide4410.9GAL, GHR, IGF1, GH1, IGFBP3, SST
30naltrexone44 49 28 1113.9PRL, GH1, GHRH, IGFBP3, IGF1
31pasireotide44 1111.9SSTR5, SSTR1, SST, SSTR2
32estrogen4410.9TRH
33cyclic amp44 2411.8GHR, SSTR1, TRH, CNC, GHRH, GAL
34cyclosomatostatin5910.8SST, SSTR1, SSTR5, SSTR2
35(1r,1s,3r/1r,1r,3s)-l-054,2645910.8SSTR5, SSTR2, SSTR1, SST
36cyn 1548065910.8SSTR5, SSTR1, SST, SSTR2
37progesterone44 59 28 11 2414.8TRH, SSTR2, IGF1, GNAS, IGFBP3, GHR
38cycloheximide4410.8TRH, TRHR, GHRH, GAL, GHR
39somatostatin59 2411.8SSTR2, SSTR1, SST, SSTR5
40vapreotide28 44 1112.8GHSR, SSTR5, SSTR2, SST
41111in-pentetreotide4410.8SST, SSTR1, SSTR2, SSTR5
42hydrocortisone44 2 59 1113.7PRL, SST, IGF1, TRH, GHSR, GH1
43dehydroepiandrosterone sulfate4410.7IGFBP3, IGF1, PRL, GH1, GHR
44tamoxifen44 49 28 1113.7PRL, IGFBP3, IGF1, GH1, GHRH, SSTR2
45dihydrotestosterone44 28 11 2413.7GH1, IGFBP3, GHR, VIP, IGF1, PRL
46leuprolide acetate4410.6GH1, IGF1, PRL, GHR
47serine4410.5GH1, GHRH, MEN1, GAL, GNAS, VIP
48acipimox44 2811.5IGF1, SST, GH1, GHRH
49buserelin44 28 1112.4SST, IGF1, IGFBP3, PRL
50glutamate4410.3SST, VIP, TRH, IGFBP3, GHRH, GHR

GO Terms for genes affiliated with Acromegaly

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16Gene Ontology
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Cellular components related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TRH, VIP, GNAS, GAL, GHR, GHRH
2extracellular spaceGO:00561510.6GHRH, GH1, SST, IGFBP3, IGF1, GHR
3secretory granuleGO:03014110.5GAL, GHRHR, PRL, TRH
4insulin-like growth factor binding protein complexGO:01694210.4IGF1, IGFBP3
5plasma membraneGO:00588610.3GNAS, GHRHR, GHR, GHSR, SSTR5, SSTR2

Biological processes related to Acromegaly according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, IGFBP3, GH1, GHRH, GHSR, GHRHR
2positive regulation of multicellular organism growthGO:04001810.9GHRHR, GHR, GHSR, GHRH, GH1
3negative regulation of cell proliferationGO:00828510.9MEN1, SSTR5, SSTR2, SSTR1, SST, IGFBP3
4growth hormone secretionGO:03025210.9GAL, GHRHR, GHSR, GHRH
5response to foodGO:03209410.9GHR, GHSR, GHRH
6response to nutrientGO:00758410.9SST, SSTR1, SSTR2, PRL
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9IGF1, GH1, GHR
8cell-cell signalingGO:00726710.8GHRH, SSTR2, SSTR1, SST, TRH
9hormone-mediated signaling pathwayGO:00975510.8GHR, GHSR, TRH
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8PRL, GH1, GHR
11G-protein coupled receptor signaling pathwayGO:00718610.8VIP, GHSR, SSTR5, SST, TRHR
12regulation of multicellular organism growthGO:04001410.8GHR, PRL, IGF1
13positive regulation of cAMP biosynthetic processGO:03081910.8GHRH, GHRHR, GNAS
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8SSTR5, SSTR2, SSTR1
15water homeostasisGO:03010410.8IGF1, GHRHR
16digestionGO:00758610.7SSTR2, SSTR1, SST
17positive regulation of osteoblast differentiationGO:04566910.7IGF1, MEN1, GNAS
18cellular response to insulin stimulusGO:03286910.7GHRHR, GHR, GHSR
19response to estradiol stimulusGO:03235510.7PRL, GH1, GHR
20positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.7IGF1, GH1, GHR
21growth hormone receptor signaling pathwayGO:06039610.6GHR, GH1
22positive regulation of growth hormone secretionGO:06012410.6GHRHR, GHRH
23response to drugGO:04249310.5SST, PRL, GAL, GNAS
24cellular response to estradiol stimulusGO:07139210.5SSTR1, SSTR2
25positive regulation of JAK-STAT cascadeGO:04642710.4GH1, PRL
26insulin-like growth factor receptor signaling pathwayGO:04800910.2IGF1, GHR

Molecular functions related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7IGF1, SST, PRL, GH1, VIP
2somatostatin receptor activityGO:00499410.6SSTR1, SSTR2, SSTR5
3growth hormone-releasing hormone receptor activityGO:01652010.5GHSR, GHRHR
4neuropeptide hormone activityGO:00518410.5VIP, GAL, TRH
5peptide hormone bindingGO:01704610.4GHSR, GHR, GHRHR
6prolactin receptor bindingGO:00514810.2PRL, GH1

Products for genes affiliated with Acromegaly

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Sources for Acromegaly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet