MCID: ACR007
MIFTS: 79

Acromegaly malady

Rare diseases, Reproductive diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Acromegaly

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (gh). it is most often diagnosed in middle-aged adults, although symptoms can appear at any age. signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. the condition is usually caused by benign tumors on the pituitary called adenomas. rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. when gh-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. last updated: 4/29/2011

MalaCards: Acromegaly, also known as infantile and juvenile forms of acromegaly, is related to pituitary apoplexy and mccune albright syndrome, and has symptoms including deep palmar creases, dysplastic/thick/grooved toenails and dysplastic/thick/grooved fingernails. An important gene associated with Acromegaly is GNAS (GNAS complex locus), and among its related pathways are Translation Insulin regulation of translation and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs bromocriptine and octreotide and the compounds somatuline and acipimox have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related mouse phenotypes are immune system and liver/biliary system.

Disease Ontology:8 A disease of metabolism that has material basis in excessive growth hormone production which results in enlargement located in limb.

Wikipedia:65 Acromegaly (/? more...

Description from OMIM:47 102200

Aliases & Classifications for Acromegaly

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
acromegaly:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acromegaly 8 9 43 47 10 45 49 62
infantile and juvenile forms of acromegaly 49
hypophyseal gigantism 49
growth hormone excess 43
somatotroph adenoma 43
pituitary gigantism 49
pituitary giant 43
gigantism 62


External Ids:

Disease Ontology8 DOID:2449
NCIt40 C84533
MeSH35 D000172
OMIM47 102200
MESH via Orphanet36 D000172, D005877
ICD10 via Orphanet26 E22.0
SNOMED-CT via Orphanet59 74107003, 80849007
UMLS via Orphanet63 C0001206, C0017547

Related Diseases for Acromegaly

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17GeneCards, 18GeneDecks
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Diseases related to Acromegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary apoplexy31.0PRL
2mccune albright syndrome30.9GNAS
3gigantism30.8AIP, IGF1, GNAS, PRL, SST, GH1
4diabetes mellitus30.6IGFBP3, GH1, GHR, SST, IGF1
5insulin resistance30.5IGF1, GNAS, SST, GHR, GH1, IGFBP3
6growth hormone deficiency30.5IGFBP3, IGF1, GHRH, GHR, GHRHR, GH1
7cushing's syndrome30.5SST, GH1
8fibrous dysplasia30.5GHR, GH1, GNAS
9neuroendocrine tumor30.4PRL, SST, SSTR2, GHRH
10adenoma30.4GHRH, GHR, GHRHR, GH1, GHSR, GAL
11pituitary adenoma30.4AIP, IGF1, GNAS, PRL, SSTR5, SST
12empty sella syndrome30.4PRL
13amenorrhea30.3PRL, IGF1
14hyperprolactinemia30.3GAL, IGF1, GNAS, PRL, SST, GHRH
15hypopituitarism30.3GH1, IGFBP3, IGF1, PRL, SST, GHRH
16pituitary tumors30.2AIP, GNAS, PRL, SSTR5, TRHR, GAL
17glucose intolerance30.2GH1, IGFBP3, IGF1
18carney complex30.2AIP, GNAS
19dwarfism30.2GHRH, GHR, IGFBP3, IGF1, GHRHR, GH1
20pituitary carcinoma30.2PRL
21hepatitis30.2GAL, GHR
22chromophobe adenoma30.1GH1, PRL
23zollinger-ellison syndrome30.1SST, GHRH
24prolactinoma30.1GNAS, PRL, SSTR5, SST, SSTR2, GHRHR
25nelson syndrome30.1PRL, SST
26diabetes insipidus30.1GHRH, PRL
27panhypopituitarism30.0GHR, GH1, IGF1, PRL
28proliferative diabetic retinopathy30.0IGF1, IGFBP3, GHR, SST
29hypogonadism30.0PRL, IGF1, GH1, IGFBP3
30hypothalamic disease29.9GH1, PRL
31rabson-mendenhall syndrome29.9IGFBP3, IGF1
32acth deficiency29.9PRL, GH1
33uremia29.9IGF1, GH1, GHR
34craniopharyngioma29.9PRL, IGF1, GH1
35turner syndrome29.8IGFBP3, IGF1, GHR
36meningioma29.8SSTR2, SSTR5, SST
37hypoglycemia29.8IGFBP3, IGF1, PRL, SST, GHRH, GHR
38osteoporosis29.8GHR, IGF1, GH1, IGFBP3
39liver cirrhosis29.8GHRH, SST, IGFBP3
40prostate cancer29.7GHRHR, IGF1, GHRH, GHR, IGFBP3
41osteosarcoma29.7IGFBP3, IGF1, GHRH, GHR, GHRHR
42hyperandrogenism29.7IGFBP3, IGF1, GNAS, GH1, PRL
43carcinoid syndrome29.7GNAS, SSTR5, SST, SSTR2, GHRH, GH1
44pheochromocytoma29.7SST, SSTR2, SSTR5, GAL, GNAS
45type 1 diabetes mellitus29.7GAL, GHRH, IGF1, SST, IGFBP3, GHR
46hypothyroidism29.6IGFBP3, IGF1, GNAS, PRL, GHRH, GHR
47hyperglycemia29.6GHRH, GHR, SST, IGFBP3, GH1, IGF1
48hyperthyroidism29.5IGF1, GNAS, PRL, SST, GHRH, GHR
49breast cancer29.4GGH, GAL, SSTR2, GHRH, GHRHR, PRL
50somatostatin analog10.8

Graphical network of the top 20 diseases related to Acromegaly:



Diseases related to acromegaly

Symptoms for Acromegaly

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47OMIM, 49Orphanet
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Clinical features from OMIM:

102200

Symptoms:

49 (show all 52)
  • deep palmar creases
  • dysplastic/thick/grooved toenails
  • dysplastic/thick/grooved fingernails
  • enlargment of jaw/large jaw
  • synophris/synophrys
  • macrodactyly/fingers hypertrophy/megalodactyly (hand)
  • broad foot
  • abnormal sole/deep creases
  • functional anomalies of the genital system
  • galactorrhea
  • somnolence/hypersomnia/parasomnia
  • diabetes mellitus
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • anomalies of teeth and dentition
  • thick lips
  • broad nose/nasal bridge
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • prognathism/prognathia
  • macroglossia/tongue protrusion/proeminent/hypertrophic
  • coarse face
  • chronic arterial hypertension
  • autosomal dominant inheritance
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • apnea/sleep apnea
  • hyperhidrosis/increased sweating
  • kyphosis
  • osteoarthritis
  • hydrarthrosis/articular/joint effusion
  • abnormal cry/voice/phonation disorder/nasal speech
  • cardiomyopathy/hypertrophic/dilated
  • acute palsy
  • acanthosis nigricans
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • rachidian/spine canal stenosis
  • tall stature/gigantism/growth acceleration
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • broad forehead
  • anomalies of the endocrine glands
  • puffy eyelids
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • hypothalamic-hypophyseal axis functional anomalies/hypopituitarism
  • facial pain/cephalalgia/migraine
  • impotence/painful erection/priapism/erection troubles
  • thick skin/pachydermia/orange skin
  • acne/acnea
  • hirsutism/hypertrichosis/increased body hair
  • broad cheeks/cherub-like/cherubin face
  • frontal bossing/prominent forehead

Drugs & Therapeutics for Acromegaly

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acromegaly

Search NIH Clinical Center for Acromegaly

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Acromegaly

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Anatomical Context for Acromegaly

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Acromegaly:

33
Pituitary, Bone, Testes, Brain, Pancreas, Lung, Skin, Thyroid, Colon, Heart, Endothelial, Tongue, Liver, Ovary, Prostate, Skeletal muscle, Myeloid, Cervix, Kidney, Pancreatic islet, Breast, Spinal cord, Hypothalamus, Uterus, Adipocyte, Tonsil

FMA organs/tissues related to Acromegaly:

14
Limb

Animal Models for Acromegaly or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acromegaly:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.3GHRHR, GHRH, SST, PRL, GNAS, IGF1
2MP:00053708.2AIP, GH1, GHR, GHRH, PRL, GNAS
3MP:00053758.2GNAS, IGF1, IGFBP3, GHR, GHRHR, GHSR
4MP:00107717.7IGF1, GAL, PRL, GHR, GHRHR, GNAS
5MP:00053897.3GAL, GH1, GHRHR, GHR, TRHR, IGF1
6MP:00036317.2PRL, GNAS, IGF1, SSTR2, GHRH, GHR
7MP:00053796.9GHR, AIP, IGFBP3, IGF1, GHRH, GAL
8MP:00053866.5GHSR, GHRHR, SSTR2, SST, PRL, GNAS
9MP:00053786.0GHSR, AIP, IGFBP3, IGF1, GNAS, TRHR
10MP:00053765.3GHSR, GAL, SSTR2, SST, GHRHR, GH1

Publications for Acromegaly

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52PubMed
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Articles related to Acromegaly:

(show top 50)    (show all 1317)
idTitleAuthorsYear
1
A consensus on the diagnosis and treatment of acromegaly complications. (22903574)
2013
2
Acromegaly and oxidative stress: impact on endothelial dysfunction and atherosclerosis. (23608960)
2013
3
Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naA^ve acromegaly. (23593161)
2013
4
Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study. (23529827)
2013
5
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
6
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
7
Preoperative lanreotide treatment improves outcome in patients with acromegaly resulting from invasive pituitary macroadenoma. (22613412)
2012
8
Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia. (22673565)
2012
9
Invasive sphenocavernous aspergilloma complicating an operated case of acromegaly. (23984200)
2011
10
Acromegaly caused by ectopic growth hormone-releasing hormone production from a bronchial carcinoid tumor. (21480145)
2011
11
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
12
Conventional and novel biomarkers of treatment outcome in patients with acromegaly: discordant results after somatostatin analog treatment compared with surgery. (20813787)
2010
13
N-terminal pro-brain natriuretic peptide in newly diagnosed acromegaly. (20930495)
2010
14
Lanreotide for the treatment of acromegaly. (19533047)
2009
15
The effect of acute application of pegvisomant alone and in combination with octreotide on endogenous GH levels during a 6-h test in patients with acromegaly on constant pegvisomant treatment. (19109045)
2009
16
Dynamic tests for the diagnosis and assessment of treatment efficacy in acromegaly. (18418712)
2008
17
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
18
Blood coagulation and fibrinolysis in patients with acromegaly: increased plasminogen activator inhibitor-1 (PAI-1), decreased tissue factor pathway inhibitor (TFPI), and an inverse correlation between growth hormone and TFPI. (19016004)
2008
19
Acromegaly. (18578866)
2008
20
Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs. (17047390)
2006
21
Acromegaly: molecular expression of somatostatin receptor subtypes and treatment outcome. (16809928)
2006
22
Predictors and rates of treatment-resistant tumor growth in acromegaly. (16061822)
2005
23
Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant. (16076947)
2005
24
Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly. (15585549)
2005
25
Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels. (16159936)
2005
26
A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. (15827109)
2005
27
GH and mortality in acromegaly. (16625851)
2005
28
Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist. (16046586)
2005
29
Cardiovascular complications in acromegaly. (15282442)
2004
30
Pegvisomant: a new treatment modality for acromegaly. (16982575)
2004
31
Octreotide long-acting release (LAR): a review of its use in the management of acromegaly. (14609359)
2003
32
Elevated intraocular levels of insulin-like growth factor I in a diabetic patient with acromegaly. (12029573)
2002
33
Primary medical therapy for acromegaly: an open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on growth hormone, insulin-like growth factor-I, and tumor size. (12364434)
2002
34
Experience with pegvisomant in the treatment of acromegaly. (11527081)
2001
35
Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly. (11083070)
2000
36
Lanreotide 60 mg, a longer-acting somatostatin analog: tumor shrinkage and hormonal normalization in acromegaly. (11788011)
2000
37
The Birmingham pituitary database: auditing the outcome of the treatment of acromegaly. (8548933)
1995
38
Assessment of GH status in acromegaly using serum growth hormone, serum insulin-like growth factor-1 and urinary growth hormone excretion. (7750196)
1995
39
The magnitude of growth hormone elevation is related with the proportion of monomeric form in acromegaly. (8845645)
1995
40
Acute effects of a single administration of dexamethasone on basal and growth hormone-releasing hormone stimulated GH secretion in acromegaly. (8137516)
1994
41
Octreotide long term treatment of acromegaly: effect of drug withdrawal on serum growth hormone/insulin-like growth factor-I concentrations and on serum gastrin/24-hour intragastric pH values. (8325938)
1993
42
Effect of long-term treatment with bromocriptine on the growth hormone response to galanin in patients with acromegaly. (7680832)
1993
43
Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (8396925)
1993
44
Clinical experience of octreotide in the treatment of acromegaly. (1358345)
1992
45
A marked molecular heterogeneity of growth hormone (GH) detected in the plasma but not pituitary of a patient with acromegaly: comparison with other acromegalics and an implication for discrepant plasma levels of GH and insulin-like growth factor. (1506622)
1992
46
Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. (1563080)
1992
47
The relationship between TSH response to TRH and GH response to dopaminergic agents in patients with acromegaly]. (1674920)
1991
48
Resistance to a long-acting somatostatin analog (SMS 201-995) reversed by surgery in acromegaly. (2273211)
1990
49
Short term treatment of acromegaly with the somatostatin analog octreotide: the first double-blind randomized placebo-controlled study on its effects. (2229278)
1990
50
Somatostatin analog treatment of acromegaly: new aspects. (2900190)
1988

Variations for Acromegaly

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Acromegaly:

1 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1GNASNM_001077488.2(GNAS): c.604C> T (p.Arg202Cys)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
2GNASNM_001077488.2(GNAS): c.605G> A (p.Arg202His)single nucleotide variantPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
3GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
4GNASNM_001077488.2(GNAS): c.604C> A (p.Arg202Ser)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
5AIPNM_003977.2(AIP): c.241C> T (p.Arg81Ter)single nucleotide variantPathogenicrs267606541GRCh37Chr 11, 67254618: 67254618
6AIPNM_003977.2(AIP): c.721A> G (p.Lys241Glu)single nucleotide variantPathogenicrs267606573GRCh37Chr 11, 67257862: 67257862
7AIPNM_003977.2(AIP): c.805_825dup21 (p.His275_Ala276insPheLysArgGlyLysAlaHis)duplicationPathogenicrs267606578GRCh37Chr 11, 67258296: 67258297
8AIPNM_003977.2(AIP): c.807C> T (p.Phe269=)single nucleotide variantPathogenicrs139407567GRCh37Chr 11, 67258278: 67258278
9AIPNM_003977.2(AIP): c.811C> T (p.Arg271Trp)single nucleotide variantPathogenicrs267606579GRCh37Chr 11, 67258282: 67258282
10AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669
11AIPNM_003977.2(AIP): c.469-1G> Asingle nucleotide variantLikely pathogenic, Pathogenicrs267606555GRCh37Chr 11, 67257508: 67257508
12AIPNM_003977.2(AIP): c.910C> T (p.Arg304Ter)single nucleotide variantPathogenicrs104894195GRCh37Chr 11, 67258381: 67258381
13AIPNM_003977.2(AIP): c.66_71delAGGAGA (p.Gly23_Glu24del)deletionLikely pathogenic, Pathogenicrs267606567GRCh37Chr 11, 67250695: 67250700
14AIPNM_003977.2(AIP): c.824dupA (p.His275Glnfs)duplicationLikely pathogenic, Pathogenicrs267606580GRCh37Chr 11, 67258295: 67258296
15AIPNM_003977.2(AIP): c.542delT (p.Ile182Serfs)deletionLikely pathogenic, Pathogenicrs267606559GRCh37Chr 11, 67257582: 67257582
16AIPNM_003977.2(AIP): c.804C> A (p.Tyr268Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121908356GRCh37Chr 11, 67258275: 67258275
17AIPNM_003977.2(AIP): c.64C> T (p.Arg22Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121908357GRCh37Chr 11, 67250693: 67250693

Expression for genes affiliated with Acromegaly

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acromegaly

Search GEO for disease gene expression data for Acromegaly.

Pathways for genes affiliated with Acromegaly

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 53QIAGEN, 51PharmGKB, 12EMD Millipore
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Pathways related to Acromegaly according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.7GNAS, IGFBP3
29.7IGF1, IGFBP3
3
Show member pathways
9.7GH1, GHRH, IGF1
4
Show member pathways
9.7SSTR2, SST, GNAS
59.6GH1, GHR, IGF1
6
Show member pathways
9.6GHRHR, GHRH, GNAS
79.6GHRHR, GHRH, GNAS
8
Show member pathways
9.5PRL, GHR, GH1
9
Show member pathways
Type III interferon signaling38
9.5PRL, GHR, GH1
109.5GH1, GHR, PRL
11
Show member pathways
9.2GH1, GHR, PRL, IGF1
129.2IGF1, PRL, GHR, GH1
139.2TRHR, GHSR, GHR
14
Show member pathways
8.9IGF1, PRL, GHRH, GHR, GH1
15
Show member pathways
Peptide GPCRs38
8.2SSTR5, SSTR2, GHSR, GAL, TRHR
16
Show member pathways
6.1TRHR, GNAS, PRL, SSTR5, SST, SSTR2
17
Show member pathways
5.9SST, SSTR5, PRL, GNAS, IGF1, SSTR2

Compounds for genes affiliated with Acromegaly

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Acromegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1somatuline459.8IGF1, SST, GH1
2acipimox45 2910.7GH1, IGF1, SST, GHRH
3quinagolide459.7IGF1, SST, GH1, PRL
4pirenzepine45 29 1111.6IGF1, SST, GHRH, GH1
5pasireotide45 1110.6SSTR2, SST, SSTR5
6cyn 154806619.6SSTR5, SST, SSTR2
7leuprolide acetate459.5IGF1, GH1, PRL, GHR
8(1r,1s,3r/1r,1r,3s)-l-054,264619.5SSTR5, SST, SSTR2
9vapreotide45 29 1111.5SST, SSTR5, SSTR2, GHSR
10cyclosomatostatin619.3SST, SSTR2, SSTR5
11buserelin45 29 1111.3PRL, SST, IGF1, IGFBP3
12clomiphene citrate459.2IGFBP3, PRL, IGF1, GH1
13naltrexone45 29 51 1112.1PRL, IGFBP3, IGF1, GH1, GHRH
14dehydroepiandrosterone sulfate459.0IGF1, PRL, GHR, GH1, IGFBP3
15pegvisomant45 1110.0GH1, IGFBP3, IGF1, SST, GHR, GHRH
16androstenedione45 249.9IGFBP3, IGF1, PRL, GHR, GH1
17hydrocortisone45 3 61 1111.9SST, GHSR, IGF1, PRL, GH1
18cabergoline45 29 1110.9GH1, IGF1, PRL, GHR, SST, IGFBP3
19triiodothyronine458.8GH1, GHRH, PRL, IGF1, IGFBP3, GHR
20dhea458.7IGF1, IGFBP3, PRL, GH1, GAL
21c-peptide458.6GAL, GH1, SST, IGFBP3, IGF1, GHR
22thyroxine45 249.6IGF1, SST, GHRH, GHR, PRL, GH1
23levodopa45 119.5SST, IGF1, PRL, GAL, GHR, GH1
24tamoxifen45 51 29 1111.4IGFBP3, PRL, IGF1, GHR, GH1, SSTR2
25pyridostigmine45 119.3IGFBP3, IGF1, PRL, GAL, GH1, GHRH
26norepinephrine45 24 1110.2IGFBP3, PRL, SST, GHRH, GH1, GAL
27naloxone45 29 51 1111.2SST, GGH, GAL, GH1, GHRH, PRL
28forskolin45 51 1110.2GNAS, SSTR2, GHRH, GHRHR, GH1, GAL
29progesterone45 29 61 24 1112.2GHR, GHRH, IGF1, GNAS, PRL, IGFBP3
30steroid458.0GHSR, IGFBP3, PRL, GH1, GHRH, GNAS
31clonidine45 51 29 1111.0IGFBP3, IGF1, SST, GHRH, GHR, GH1
32bromocriptine45 29 1110.0GH1, GAL, GHR, GHRH, SST, PRL
33thymidine45 248.8GHR, IGF1, GGH, GH1, SSTR2, SSTR5
34cycloheximide457.8GAL, TRHR, GH1, GHR, IGFBP3, SST
35ghrp457.8GHSR, GH1, GHRHR, GHR, GHRH, SST
36estradiol45 24 119.7GHRH, IGFBP3, IGF1, GHSR, PRL, GHR
37adenylate457.5GNAS, GAL, IGFBP3, GHSR, SST, SSTR2
38lanreotide45 298.5GHR, GH1, SSTR2, GHSR, GHRH, SST
39testosterone45 61 24 1110.5GHRH, SST, GHR, GAL, GHSR, IGFBP3
40gnrh457.4GAL, IGFBP3, IGF1, GNAS, PRL, SST
41estrogen457.3GAL, GHRH, GHSR, GH1, GHR, PRL
42dopamine45 29 24 1110.2SST, SSTR2, GHR, GH1, GHSR, GAL
43glutamate457.2GHR, GGH, GAL, GHRHR, GHRH, SST
44ribonucleic acid457.2IGFBP3, IGF1, GNAS, PRL, SSTR5, SSTR2
45hexarelin45 298.1GHRH, SST, GHR, GHRHR, GH1, GHSR
46dexamethasone45 51 29 1110.1GAL, PRL, SST, GHSR, GH1, GHRHR
47arginine456.9IGFBP3, GNAS, GHRHR, PRL, GAL, SST
48acth456.7GAL, GHSR, GH1, IGFBP3, IGF1, GNAS
49octreotide45 61 29 118.8GHRH, GHR, GH1, GHSR, GAL, GGH
50glucose455.7GGH, GAL, GHSR, GH1, GHRHR, GHR

GO Terms for genes affiliated with Acromegaly

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Sources:
16Gene Ontology
See all sources

Cellular components related to Acromegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.4IGF1, IGFBP3
2extracellular spaceGO:0056157.6IGFBP3, IGF1, SST, GHRH, GHR, GH1
3plasma membraneGO:0058867.5IGF1, GNAS, SSTR5, SSTR2, GHR, GHRHR
4extracellular regionGO:0055767.3GAL, IGFBP3, IGF1, GNAS, PRL, SST

Biological processes related to Acromegaly according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1water homeostasisGO:03010410.1GHRHR, IGF1
2growth hormone receptor signaling pathwayGO:06039610.1GHR, GH1
3insulin-like growth factor receptor signaling pathwayGO:04800910.0GHR, IGF1
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0IGF1, GHR, GH1
5positive regulation of growth hormone secretionGO:06012410.0GHRH, GHRHR
6positive regulation of JAK-STAT cascadeGO:04642710.0GH1, PRL
7positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9GH1, GHR, IGF1
8positive regulation of cAMP biosynthetic processGO:0308199.9GHRHR, GHRH, GNAS
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9GHRHR, GHRH, GNAS
10activation of adenylate cyclase activityGO:0071909.9GHRHR, GNAS
11JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8GH1, GHR, PRL
12JAK-STAT cascadeGO:0072599.8GH1, GHR
13regulation of multicellular organism growthGO:0400149.8GHR, PRL, IGF1
14cAMP-mediated signalingGO:0199339.8GHRH, GHRHR
15hormone-mediated signaling pathwayGO:0097559.8GHSR, GHR
16response to foodGO:0320949.7GHSR, GHR, GHRH
17growth hormone secretionGO:0302529.7GHSR, GHRHR, GHRH
18positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6GH1, GHR
19cellular response to insulin stimulusGO:0328699.6GHR, GHRHR, GHSR
20G-protein coupled receptor signaling pathwayGO:0071869.2TRHR, GHSR, SST, SSTR5
21positive regulation of multicellular organism growthGO:0400189.1GHRH, GHR, GHRHR, GH1, GHSR
22negative regulation of cell proliferationGO:0082859.1IGFBP3, IGF1, SSTR5, SST, SSTR2
23response to insulinGO:0328689.0GHRHR, GAL, GGH
24response to drugGO:0424938.8GNAS, SST, GAL, GGH
25positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435688.7GHSR, GH1, GHRHR, GHRH, IGF1, IGFBP3

Molecular functions related to Acromegaly according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.9GH1, PRL
2growth factor bindingGO:0198389.8GHRHR, GHR
3somatostatin receptor activityGO:0049949.7SSTR5, SSTR2
4growth hormone-releasing hormone receptor activityGO:0165209.6GHSR, GHRHR
5hormone activityGO:0051799.5GH1, SST, PRL, IGF1
6peptide hormone bindingGO:0170469.4GHR, GHRHR, GHSR
7protein bindingGO:0055156.6AIP, IGFBP3, IGF1, GNAS, PRL, SSTR2

Products for genes affiliated with Acromegaly

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acromegaly

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet