MCID: ACT087
MIFTS: 42

Acth Deficiency

Categories: Genetic diseases, Endocrine diseases

Aliases & Classifications for Acth Deficiency

MalaCards integrated aliases for Acth Deficiency:

Name: Acth Deficiency 24 29 52
Adrenocorticotropic Hormone Deficiency 69
Adrenocorticotropic Hormone Deficiency 24

Classifications:



Summaries for Acth Deficiency

MalaCards based summary : Acth Deficiency, also known as adrenocorticotropic hormone deficiency, is related to late-onset isolated acth deficiency and adrenocorticotropic hormone deficiency. An important gene associated with Acth Deficiency is TBX19 (T-Box 19), and among its related pathways/superpathways are G alpha (s) signalling events and Corticotropin-releasing hormone signaling pathway. The drugs Cosyntropin and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and endocrine/exocrine gland

Related Diseases for Acth Deficiency

Diseases related to Acth Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
id Related Disease Score Top Affiliating Genes
1 late-onset isolated acth deficiency 11.9
2 adrenocorticotropic hormone deficiency 11.7
3 african histoplasmosis 10.7 POMC PRL
4 genital dwarfism, turner type 10.7 PRL TRH
5 lymphoepithelioma-like carcinoma 10.7 POMC PRL
6 cholangiolocellular carcinoma 10.6 POMC TRH
7 olfactory nerve neoplasm 10.6 POMC PRL
8 osteoclast-like giant cell neoplasm of the pancreas 10.6 POMC PRL
9 renal pelvis carcinoma 10.6 CRH POMC
10 vertebral artery occlusion 10.6 POMC PRL
11 actinobacillosis 10.6 CRH POMC PRL
12 ulcerative blepharitis 10.6 CRH POMC PRL
13 euthyroid sick syndrome 10.6 CRH PRL
14 trabecular follicular adenocarcinoma 10.5 CRH POMC PRL
15 uterine corpus adenocarcinofibroma 10.5 CRH POMC PRL
16 bronchiectasis 10.5 CRH POMC PRL
17 febrile infection-related epilepsy syndrome 10.5 CRH POMC
18 hypertensive encephalopathy 10.5 CRH POMC PRL
19 g6pc3 deficiency 10.5 GH1 PRL
20 fibrolamellar carcinoma 10.5 POMC PRL TRH
21 dressler's syndrome 10.5 CRH POMC
22 male reproductive organ benign neoplasm 10.5 POMC PRL TRH
23 potter's syndrome 10.4 LHX3 PROP1
24 immune system organ benign neoplasm 10.4 POMC PRL PROP1
25 combined t cell and b cell immunodeficiency 10.4 GH1 PRL
26 retinitis pigmentosa 46 10.4 POMC PRL
27 lymphoma, gastric non hodgkins type 10.3 GH1 POMC TBX19
28 sesame syndrome 10.3 PCSK1 POMC TBX19
29 cardiovascular organ benign neoplasm 10.3 CRH POMC PRL TRH
30 vestibular gland benign neoplasm 10.3 CRH POMC PRL TRH
31 acute gonococcal salpingitis 10.3 CRH POMC PRL TRH
32 capillary lymphangioma 10.2 CRH GH1 POMC
33 glassy cell carcinoma of the cervix 10.2 GH1 PRL
34 posterior uveal melanoma 10.1 CRH HSD11B1 POMC
35 coloboma 10.1 CRH HSD11B1 POMC
36 skin meningioma 10.1 GH1 PRL TRH
37 pituitary adenoma, prolactin-secreting 10.1 GH1 PRL
38 intermittent squint 10.1 CRH GH1 POMC PRL
39 complement receptor deficiency 10.1 HESX1 POU1F1 PROP1
40 adrenal cortex disease 10.1 CRH GH1 POMC PRL
41 chromosome 11p13 deletion syndrome, distal 10.0 CRH GH1 POMC PRL
42 aortic valve atresia 10.0 GH1 POMC PRL TRH
43 hypothyroidism 10.0
44 lactic acidosis 10.0 GH1 POMC PRL TRH
45 protein s deficiency 10.0 GH1 POMC PRL TRH
46 strabismus 10.0 GH1 POMC PRL TRH
47 diencephalic neoplasm 10.0 GH1 POMC PRL TRH
48 alpha-methylacyl-coa racemase deficiency 10.0 GH1 POMC PRL TRH
49 pituitary adenoma, acth-secreting 10.0 GH1 POMC PRL TRH
50 thrombophilia 10.0 GH1 POMC PRL TRH

Graphical network of the top 20 diseases related to Acth Deficiency:



Diseases related to Acth Deficiency

Symptoms & Phenotypes for Acth Deficiency

GenomeRNAi Phenotypes related to Acth Deficiency according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.72 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.72 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.72 MC4R
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.72 MC4R
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.72 POMC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.72 HESX1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.72 PCSK1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.72 PCSK1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 MC4R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.72 PCSK1 POMC HESX1 MC4R
12 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.72 PCSK1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 MC4R PCSK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.72 HESX1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.72 MC4R PCSK1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.72 PCSK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.72 MC4R
18 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.72 HESX1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.72 POMC
20 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.72 POMC

MGI Mouse Phenotypes related to Acth Deficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 TBX19 TRH POU1F1 PRL PROP1 PCSK1
2 growth/size/body region MP:0005378 10.17 PROP1 TBX19 TRH POU1F1 HESX1 PCSK1
3 behavior/neurological MP:0005386 10.06 PROP1 POMC PRL PCSK1 HSD11B1 ASS1
4 homeostasis/metabolism MP:0005376 9.97 PROP1 TBX19 TRH POU1F1 PRL PCSK1
5 adipose tissue MP:0005375 9.91 POMC PCSK1 HSD11B1 PITX1 MC4R CRH
6 nervous system MP:0003631 9.8 PROP1 TBX19 TRH POU1F1 PRL HESX1
7 hearing/vestibular/ear MP:0005377 9.73 POU1F1 HESX1 PITX1 LHX3 ASS1 NEUROD1
8 respiratory system MP:0005388 9.1 PROP1 NEUROD1 HESX1 HSD11B1 MC4R CRH

Drugs & Therapeutics for Acth Deficiency

Drugs for Acth Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cosyntropin Approved Phase 4 16960-16-0 16129617
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-23-7 5754 657311
4 Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
8
Butyric Acid Experimental Phase 4,Phase 2,Phase 3 107-92-6 264
9 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
10 Cortisol succinate Phase 4,Phase 2,Phase 3
11 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1
12 Hormone Antagonists Phase 4,Phase 2,Phase 3
13 Hormones Phase 4,Phase 2,Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
15 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3
16 Hydrocortisone acetate Phase 4,Phase 2,Phase 3
17 glucocorticoids Phase 4,Phase 2,Phase 3
18 Adrenocorticotropic Hormone Phase 4,Phase 2,Phase 1
19 beta-endorphin Phase 4,Phase 2
20 Melanocyte-Stimulating Hormones Phase 4,Phase 2
21 Antiemetics Phase 4
22 Antineoplastic Agents, Hormonal Phase 4
23 Antioxidants Phase 4
24 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Gastrointestinal Agents Phase 4
26 Methylprednisolone acetate Phase 4
27 Methylprednisolone Hemisuccinate Phase 4
28 Micronutrients Phase 4
29 Neuroprotective Agents Phase 4
30 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Prednisolone acetate Phase 4
32 Prednisolone hemisuccinate Phase 4
33 Prednisolone phosphate Phase 4
34 Protective Agents Phase 4
35 Retinol palmitate Phase 4
36 Trace Elements Phase 4
37 Vitamins Phase 4
38 Immunoglobulin A Phase 4
39 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3
40 retinol Nutraceutical Phase 4
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
42
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
43
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
44 BB 1101 Phase 2, Phase 3
45 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
46 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
47 insulin Phase 2, Phase 3
48 Insulin, Globin Zinc Phase 2, Phase 3
49 Adrenergic Agents Phase 2, Phase 3,Phase 1
50 Adrenergic Agonists Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show all 26)

id Name Status NCT ID Phase Drugs
1 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4 Synacthen (Tetracosactrin)
2 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
3 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
4 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
5 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
6 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
7 Setmelanotide for the Treatment of Early-Onset POMC Deficiency Obesity Recruiting NCT02896192 Phase 2, Phase 3 Setmelanotide;Placebo
8 Setmelanotide Phase 2 Treatment Trial in Patients With Rare Genetic Disorders of Obesity Recruiting NCT03013543 Phase 2, Phase 3 Setmelanotide
9 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
10 RM-493 Treatment Trial in Proopiomelanocortin (POMC) Deficient Patients Recruiting NCT02507492 Phase 2 RM-493
11 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RM-493 Administered to Healthy, Obese, Non-diabetic Volunteers Completed NCT02431442 Phase 1 RM-493;Placebo
12 A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis Completed NCT00461448 Phase 1
13 Safety, Pharmacokinetics and Pharmacodynamics of NBI-77860 in Adolescent Females With Congenital Adrenal Hyperplasia Withdrawn NCT02349503 Phase 1 NBI-77860;NBI-77860;NBI-77860
14 Cortisol Response to Adrenocorticotrophin (ACTH) in Acute Stress Unknown status NCT00493389 Adrenocorticotrophic hormone
15 Epidural Analgesia, Beta-Endorphin Concentrations in Colostrum, and Infant Neurobehavior as Breast-Feeding Predictors Unknown status NCT01191970
16 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
17 Adrenal Function in Critical Illness Completed NCT00156767
18 Drug Use Investigation of Somatropin for GHD-ADULTS. Completed NCT00601419 Somatropin
19 The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis Completed NCT01282164
20 Hypopituitarism After Aneurismal Subarachnoid Hemorrhage Completed NCT00962559
21 Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests Recruiting NCT02818660 Synachten
22 Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries Active, not recruiting NCT01250132
23 Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency. Active, not recruiting NCT01862380
24 Maternal Serum Ferritin and Low Neonatal Birth Weight Active, not recruiting NCT02738463
25 Ascorbic Acid Treatment in Congenital Glucocorticoids and Mineralocorticoids Deficiency Due to NNT Mutation Enrolling by invitation NCT02838472 Ascorbic Acid
26 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Enrolling by invitation NCT02878018 Qi ji shen kang lotion;Zhubai lotion;More Kidney lotion;Angiotensin-converting enzyme inhibitor orangiotensin II receptor blocker ;Tripterygium Glycosides;Adrenocorticotropic hormone ;Other Immunosuppressant

Search NIH Clinical Center for Acth Deficiency

Genetic Tests for Acth Deficiency

Genetic tests related to Acth Deficiency:

id Genetic test Affiliating Genes
1 Acth Deficiency 29 24 TBX19

Anatomical Context for Acth Deficiency

MalaCards organs/tissues related to Acth Deficiency:

39
Testes, Pituitary, Thyroid, Brain, Breast, Bone, Hypothalamus

Publications for Acth Deficiency

Articles related to Acth Deficiency:

(show top 50) (show all 122)
id Title Authors Year
1
Isolated ACTH deficiency probably induced by autoimmune-related mechanism evoked with nivolumab. ( 28334791 )
2017
2
Hyponatremia can be a powerful predictor of the development of isolated ACTH deficiency associated with nivolumab treatment [Letter to the Editor]. ( 28070057 )
2017
3
Isolated ACTH deficiency in a patient with empty sella as revealed by severe hyponatremia. ( 27176077 )
2016
4
Neonatal isolated ACTH deficiency (IAD): a potentially life-threatening but treatable cause of neonatal cholestasis. ( 27535729 )
2016
5
Repeating ACTH Stimulation Test Is Necessary to Diagnose ACTH Deficiency in Neonatal Hypopituitarism With Initial False Negative Result. ( 27335928 )
2014
6
Acylated ghrelin as provocative test for the diagnosis of ACTH deficiency in patients with hypothalamus-pituitary disease. ( 25487034 )
2014
7
Adult idiopathic isolated ACTH deficiency: a short series and literature review. ( 24463998 )
2013
8
Repeated hypoglycemia caused by the overproduction of anti-insulin antibodies and isolated ACTH deficiency in a type 2 diabetic patient receiving insulin therapy. ( 23349155 )
2013
9
Sertraline alleviated osmophobia caused by partial hypopituitarism with isolated ACTH deficiency. ( 22902256 )
2013
10
Primary empty sella with isolated ACTH deficiency and microprolactinoma. ( 22329726 )
2012
11
Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations. ( 22170728 )
2012
12
Early-onset severe obesity with ACTH deficiency and red hair in a boy: the POMC deficiency. ( 23431750 )
2012
13
Isolated ACTH deficiency presenting with a glucocorticoid-responsive triphasic wave coma. ( 22821112 )
2012
14
Patient with isolated adrenocorticotropic hormone (ACTH) deficiency who was depressive before glucocorticoid replacement, and exhibited stupor during continuous ACTH test. ( 21851467 )
2011
15
Severe Hypoglycemia due to Isolated ACTH Deficiency in Children: A New Case Report and Review of the Literature. ( 21760815 )
2011
16
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. ( 21400210 )
2011
17
A novel mutation of LHX3 is associated with combined pituitary hormone deficiency including ACTH deficiency, sensorineural hearing loss, and short neck-a case report and review of the literature. ( 21249393 )
2011
18
Congenital ACTH deficiency as a cause of hypoglycemia in a newborn infant. ( 22121139 )
2011
19
Clinical, biological and genetic analysis of 8 cases of congenital isolated adrenocorticotrophic hormone (ACTH) deficiency. ( 22028893 )
2011
20
ACTH deficiency and PGI(2) therapy in chronic thromboembolic pulmonary hypertension. ( 21093079 )
2011
21
Isolated acquired ACTH deficiency and primary hypothyroidism: a short series and review. ( 19110973 )
2011
22
Focal segmental glomerulosclerosis in a patient with isolated ACTH deficiency and reversible hypothyroidism. ( 19809785 )
2010
23
A Case of Transient ACTH Deficiency Associated with Polymyalgia Rheumatica. ( 23946678 )
2010
24
Pituicytoma and isolated ACTH deficiency. ( 19408127 )
2009
25
Torsade de pointes associated with recurrent ampulla cardiomyopathy in a patient with idiopathic ACTH deficiency. ( 19506326 )
2009
26
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. ( 19808848 )
2009
27
Prevalence of maturity-onset isolated ACTH deficiency (IAD) in 2005: Japanese cohort studies. ( 18552459 )
2008
28
Gene symbol: TBX19. Disease: ACTH deficiency, isolated? ( 20960606 )
2008
29
May primary empty sella turcica be a cause of isolated ACTH deficiency? A case report and the review of related literature. ( 18063931 )
2007
30
Isolated ACTH deficiency presenting as severe hypercalcaemia. ( 17371483 )
2007
31
A case of post-traumatic isolated ACTH deficiency with spontaneous recovery 9 months after the event. ( 16421141 )
2006
32
ACTH deficiency in childhood cancer survivors. ( 15700255 )
2005
33
Diagnosis and treatment of ACTH deficiency. ( 15711914 )
2005
34
Isolated ACTH deficiency associated with Crohn's disease. ( 15762046 )
2004
35
A syndrome with multiple malformations, mental retardation, and ACTH deficiency. ( 15054849 )
2004
36
Isolated ACTH deficiency with Graves' disease: a case report. ( 15004417 )
2004
37
TPIT mutations are associated with early-onset, but not late-onset isolated ACTH deficiency. ( 15476446 )
2004
38
A trial of intranasal ACTH(1-24) administration to a patient with isolated ACTH deficiency. ( 14737049 )
2004
39
[Tpit mutations reveal a new model of pituitary differentiation and account for isolated ACTH deficiency]. ( 15525497 )
2004
40
Conventional glucocorticoid replacement overtreats adult hypopituitary patients with partial ACTH deficiency. ( 15163331 )
2004
41
A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations. ( 15666849 )
2004
42
An assessment of bone mineral density in patients with Addison's disease and isolated ACTH deficiency treated with glucocorticoid. ( 15256782 )
2004
43
Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. ( 12651888 )
2003
44
Preclinical Cushing's syndrome presenting with isolated adrenocorticotropin (ACTH) deficiency-like manifestations and severe hypoalbuminemia without overt adrenal masses in a patient with Chilaiditi syndrome and mental retardation. ( 12793711 )
2003
45
Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: a report of an autopsied case. ( 12952371 )
2003
46
T-box and isolated ACTH deficiency. ( 11916612 )
2002
47
Does radiation therapy for brain tumor affect pituitary function, resulting in isolated ACTH deficiency? ( 12135170 )
2002
48
Effect of ACTH on renal excretion of purine bases in a patient with isolated ACTH deficiency. ( 10727684 )
2000
49
A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and impaired water diuresis during glucocorticoid replacement therapy. ( 11228040 )
2000
50
A case of isolated ACTH deficiency presenting with hypercalcaemia. ( 11220994 )
2000

Variations for Acth Deficiency

ClinVar genetic disease variations for Acth Deficiency:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TBX19 NM_005149.2(TBX19): c.856C> T (p.Arg286Ter) single nucleotide variant Pathogenic rs74315376 GRCh37 Chromosome 1, 168274374: 168274374
2 TBX19 NM_005149.2(TBX19): c.383C> T (p.Ser128Phe) single nucleotide variant Pathogenic rs74315377 GRCh37 Chromosome 1, 168260577: 168260577
3 TBX19 NM_005149.2(TBX19): c.257T> G (p.Met86Arg) single nucleotide variant Pathogenic rs74315378 GRCh37 Chromosome 1, 168260451: 168260451
4 TBX19 NM_005149.2(TBX19): c.782delA (p.Asn261Ilefs) deletion Pathogenic rs730880274 GRCh37 Chromosome 1, 168274300: 168274300

Expression for Acth Deficiency

Search GEO for disease gene expression data for Acth Deficiency.

Pathways for Acth Deficiency

Pathways related to Acth Deficiency according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.66 CRH MC4R POMC
2 11.3 CRH POMC TBX19
3 11.05 POMC POU1F1 PRL
4 10.49 MC4R POMC
5 9.47 CRH POMC

GO Terms for Acth Deficiency

Cellular components related to Acth Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.96 GH1 PRL
2 transcription factor complex GO:0005667 8.92 LHX3 PITX1 POU1F1 PROP1

Biological processes related to Acth Deficiency according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.7 LHX3 NEUROD1 PITX1 POMC POU1F1 PROP1
2 lung development GO:0030324 9.61 CRH HSD11B1 LHX3
3 peptide hormone processing GO:0016486 9.51 PCSK1 POMC
4 positive regulation of JAK-STAT cascade GO:0046427 9.49 GH1 PRL
5 response to corticosterone GO:0051412 9.48 CRH TRH
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.46 GH1 PRL
7 adenohypophysis development GO:0021984 9.4 POU1F1 PROP1
8 glucocorticoid biosynthetic process GO:0006704 9.37 CRH HSD11B1
9 transcription from RNA polymerase II promoter GO:0006366 9.35 LHX3 NEUROD1 PITX1 POU1F1 PROP1
10 negative regulation of feeding behavior GO:2000252 9.32 MC4R TRH
11 somatotropin secreting cell differentiation GO:0060126 9.26 POU1F1 PROP1
12 pituitary gland development GO:0021983 9.02 HESX1 LHX3 PITX1 POU1F1 TBX19

Molecular functions related to Acth Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 HESX1 LHX3 NEUROD1 PITX1 POU1F1 PROP1
2 chromatin binding GO:0003682 9.71 HESX1 NEUROD1 POU1F1 PROP1
3 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.56 LHX3 NEUROD1 PITX1 POU1F1
4 RNA polymerase II transcription factor binding GO:0001085 9.54 LHX3 PITX1 POU1F1
5 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.35 HESX1 LHX3 NEUROD1 PITX1 POU1F1
6 prolactin receptor binding GO:0005148 9.16 GH1 PRL
7 hormone activity GO:0005179 9.02 CRH GH1 POMC PRL TRH

Sources for Acth Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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