MCID: ACT010
MIFTS: 67

Acth-Secreting Pituitary Adenoma malady

Endocrine diseases, Reproductive diseases, Cancer diseases, Rare diseases categories

Summaries for Acth-Secreting Pituitary Adenoma

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9Disease Ontology, 48OMIM, 34MalaCards
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Disease Ontology:9 A functioning pituitary adenoma that characterized by excess cortisol a primary cause of cushing's syndrome.

MalaCards: Acth-Secreting Pituitary Adenoma, also known as pituitary adenoma, acth-secreting, is related to pituitary adenoma and adenoma, and has symptoms including pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer, urinary/renal lithiasis/kidney stones/nephritic colic and round face. An important gene associated with Acth-Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Jak-STAT signaling pathway. The drugs aminoglutethimide and mitotane and the compounds acetyl-podocarpic dimer and gw3965 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, skin and bone, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Description from OMIM:48 219090

Aliases & Classifications for Acth-Secreting Pituitary Adenoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 10diseasecard, 48OMIM, 50Orphanet, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
pituitary dependent cushing syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acth-secreting pituitary adenoma 9 11 63
pituitary adenoma, acth-secreting 10 48
pituitary acth-secreting adenoma 10 48
pituitary-dependent cushing's disease 63
pituitary dependent cushing syndrome 50
pituitary corticotroph micro-adenoma 50
acth-producing pituitary adenoma 9
corticotroph pituitary adenoma 50
corticotroph adenoma 9
cushing syndrome 63
corticotropinoma 9
cushing disease 50


External Ids:

Disease Ontology9 DOID:7004
OMIM48 219090
NCIt41 C7462
MeSH36 D049913
MESH via Orphanet37 D047748
SNOMED-CT59 254958004, 21109002
ICD10 via Orphanet27 E24.0
SNOMED-CT via Orphanet60 190502001
UMLS via Orphanet64 C0221406
ICD1026 E24.0

Related Diseases for Acth-Secreting Pituitary Adenoma

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18GeneCards, 19GeneDecks
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Diseases related to Acth-Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.3PPARG, GHRL, AIP, LIF, LIFR, NR3C1
2adenoma31.2GHRL, CDKN2A, AIP, LIF, LIFR, CCND1
3cushing's syndrome30.5NR3C1, GIP
4leukemia30.3LIFR, CCND1, NR1H2, NR3C1, GAPDH, CDKN2A
5nelson syndrome30.3NR3C1, PPARG
6pituitary tumors30.2GHRL, NR1H2, AIP, PPARG, LIF
7obesity29.6GAPDH, NR1H2, NR3C1, GHRL, LIF, GIP
8teratoma10.3
9addison's disease10.3
10meningioma10.3
11familial glucocorticoid deficiency10.3
12acromegaly10.2
13craniopharyngioma10.2
14lung cancer10.2
15x-linked adrenal hypoplasia congenita10.2
16choristoma10.2
17pituitary-dependent cushing's disease10.1
18esophageal cancer10.1CDKN2A, CCND1
19hypopituitarism10.1CRHBP, GHRL
20morbid obesity10.0GHRL
21embryonal cancer10.0LIFR, NR1H2, LIF
22malignant acth producing neoplasm of pituitary gland10.0
23adrenal gland hyperfunction10.0GHRL, NR3C1
24glucose intolerance10.0PPARG, NR3C1, GHRL
25polycystic ovary syndrome10.0GHRL, NR1H2, PPARG
26osteoporosis10.0NR1H2, LIF, NR3C1
27familial hyperlipidemia10.0LIF, PPARG, NR3C1
28arthritis10.0NR1H2, LIFR, LIF, GHRL
29hyperinsulinism10.0NR1H2, PPARG, GHRL
30prolactinoma10.0AIP, LIF, LIFR, GAPDH
31papilloma10.0CDKN2A, GAPDH, NR1H2
32infertility10.0NR1H2, LIFR, GAPDH, LIF
33metabolic syndrome x10.0GHRL, NR3C1, NR1H2, PPARG
34hypertrophy of breast10.0NR1H2, GHRL, LIF, PPARG
35non-small cell lung carcinoma10.0CDKN2A, PPARG, CCND1
36myeloma10.0LIFR, CCND1, LIF, NR3C1, PRKCD
37thyroid cancer10.0PPARG, CCND1, GAPDH
38choriocarcinoma10.0GAPDH, LIFR, PPARG, LIF
39atherosclerosis10.0NR1H3, NR1H2, LIF, PPARG, GHRL
40viral infectious disease10.0NR1H2, NR3C1, GAPDH, LIF
41galactosemia10.0GAPDH, NR1H2, PPARG, NR3C1
42lung adenocarcinoma10.0CCND1, PRKCD, CDKN2A, GAPDH
43breast cancer9.9LIFR, CCND1, GHRL, NR1H2, GAPDH
44alzheimer's disease9.9GAPDH, NR1H2, CRHBP, LIF, PPARG
45retinoblastoma9.9PRKCD, CCND1, CDKN2A, PPARG, NR1H2
46asthma9.9GAPDH, NR1H2, GHRL, NR3C1, LIFR, LIF
47ovarian cancer9.9LIF, CCND1, GAPDH, CDKN2A, NR1H2
48glioblastoma multiforme9.9PPARG, CCND1, CDKN2A, GAPDH
49type 2 diabetes mellitus9.9PPARG, NR1H2, NR3C1, GHRL, GIP
50insulin resistance9.9NR1H2, NR3C1, GIP, PPARG, GHRL

Graphical network of the top 20 diseases related to Acth-Secreting Pituitary Adenoma:



Diseases related to acth-secreting pituitary adenoma

Symptoms for Acth-Secreting Pituitary Adenoma

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

219090

Clinical features from OMIM:

219090

Symptoms:

50 (show all 40)
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • round face
  • sterility/hypofertility
  • psychosis/schizophrenia/maniac disorder
  • facial pain/cephalalgia/migraine
  • venous thrombosis/phlebitis/thrombophlebitis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • cortico-adrenal hyperplasia/hypersecretion
  • bruisability
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • cushingoid morphotype
  • truncal obesity
  • abnormal fat distribution/lipodystrophy
  • onyxis/paronyxis/ungual inflammation
  • precocious menopause/secondary amenorrhea
  • acute abdominal pain/colic
  • acne/acnea
  • obnubilation/coma/lethargia/desorientation
  • mild visual loss/impaired visual acuity
  • osteonecrosis/bone infarction
  • cataract/lens opacification
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • diabetes mellitus
  • chronic arterial hypertension
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • visual loss/blindness/amblyopia
  • myopathy
  • mutiple fractures/bone fragility
  • thin skin
  • hirsutism/hypertrichosis/increased body hair
  • telangiectasiae of the skin
  • chronic skin infection/ulcerations/ulcers/cancrum
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cardiomyopathy/hypertrophic/dilated
  • asthenia/fatigue/weakness
  • hypokalemia
  • sleep and vigilance disorders

Drugs & Therapeutics for Acth-Secreting Pituitary Adenoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Acth-Secreting Pituitary Adenoma

Drug clinical trials:

Search ClinicalTrials for Acth-Secreting Pituitary Adenoma

Search NIH Clinical Center for Acth-Secreting Pituitary Adenoma

Search CenterWatch for Acth-Secreting Pituitary Adenoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Acth-Secreting Pituitary Adenoma

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Anatomical Context for Acth-Secreting Pituitary Adenoma

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34MalaCards
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MalaCards organs/tissues related to Acth-Secreting Pituitary Adenoma:

34
Pituitary, Skin, Bone, Kidney, Liver

Animal Models for Acth-Secreting Pituitary Adenoma or affiliated genes

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38MGI
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Publications for Acth-Secreting Pituitary Adenoma

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53PubMed
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Articles related to Acth-Secreting Pituitary Adenoma:

(show all 22)
idTitleAuthorsYear
1
Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells. (23667519)
2013
2
miR-26a plays an important role in cell cycle regulation in ACTH-secreting pituitary adenomas by modulating protein kinase CI'. (23525216)
2013
3
Nasally located ectopic ACTH-secreting pituitary adenoma (EAPA) causing Nelson's syndrome: diagnostic challenges. (24065616)
2013
4
Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. (24379119)
2013
5
Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma, absence of stigmata of Cushing's syndrome and unusual histologic features. (22570980)
2012
6
Visual vignette. Ectopic ACTH-secreting pituitary adenoma. (21803709)
2011
7
ICA Occlusion by an ACTH-secreting pituitary adenoma post-TSS and irradiation. (22399870)
2011
8
Liver X receptor-I+/I^ expression ratio is increased in ACTH-secreting pituitary adenomas. (21356276)
2011
9
An ACTH-secreting pituitary adenoma within the sphenoid sinus. (20424367)
2010
10
Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas. (20616110)
2010
11
Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. (20719856)
2010
12
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
13
A patient with recurrent hypercortisolism after removal of an ACTH-secreting pituitary adenoma due to an adrenal macronodule. (17185905)
2006
14
ACTH-secreting pituitary adenoma within an ovarian teratoma. (16137552)
2005
15
Mutation analysis of leukemia inhibitory factor-receptor (LIF-R) in ACTH-secreting pituitary adenomas. (15372367)
2004
16
Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. (12379847)
2002
17
Decreased expression of corticotropin-releasing factor-binding protein mRNA in ACTH-secreting pituitary adenomas. (10768834)
2000
18
Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine. (7508871)
1994
19
Vasopressin enhances a calcium current in human ACTH-secreting pituitary adenoma cells. (2844618)
1988
20
Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. (6326445)
1984
21
Increase of beta-endorphin in cerebrospinal fluid after removal of ACTH-secreting pituitary adenoma. (6272176)
1981
22
ACTH secreting pituitary adenoma in an infant of 18 months. Immunohistochemical, electron-microscopic, and in-vitro studies. (6278457)
1981

Variations for Acth-Secreting Pituitary Adenoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Acth-Secreting Pituitary Adenoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1GNAI2NM_002070.3(GNAI2): c.535C> G (p.Arg179Gly)single nucleotide variantPathogenicrs137853226GRCh37Chr 3, 50293694: 50293694
2GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
3GNASNM_001077488.2(GNAS): c.684G> C (p.Gln228His)single nucleotide variantPathogenicrs137854533GRCh37Chr 20, 57484597: 57484597
4AIPNM_003977.2(AIP): c.911G> A (p.Arg304Gln)single nucleotide variantPathogenicrs104894190GRCh37Chr 11, 67258382: 67258382

Expression for genes affiliated with Acth-Secreting Pituitary Adenoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acth-Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Acth-Secreting Pituitary Adenoma.

Pathways for genes affiliated with Acth-Secreting Pituitary Adenoma

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome
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Pathways related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCND1, LIFR
2
Show member pathways
Type III interferon signaling39
9.6CCND1, LIFR, LIF
3
Show member pathways
9.5GNAI2, PRKCD, CCND1
4
Show member pathways
Development A1 receptor signaling61
G protein signaling G Protein alpha q signaling cascades61
9.5CCND1, PRKCD, GNAI2
5
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.4PRKCD, CCND1, NR3C1
6
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.4PPARG, LIFR, PRKCD
7
Show member pathways
9.4GNAI2, LIF, LIFR, PRKCD
89.3CDKN2A, CCND1, PRKCD
9
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.3CDKN2A, CCND1, PRKCD
10
Show member pathways
9.3AVPR1B, GNAI2, PRKCD, CCND1
11
Show member pathways
9.2AVPR1B, GNAI2, GIP, GHRL, NR3C1
12
Show member pathways
Nuclear Receptors39
9.2PPARG, NR1H3, NR3C1, NR1H2
13
Show member pathways
9.1GNAI2, LIF, LIFR, PRKCD, NR3C1
14
Show member pathways
9.0GNAI2, LIF, LIFR, PRKCD, CCND1
158.9NR3C1, NR1H3, LIFR, LIF, PPARG
16
Show member pathways
8.9CDKN2A, CCND1, PRKCD, LIFR, GNAI2
178.9TBX19, CRHBP, PRKCD, GNAI2
18
Show member pathways
8.6GNAI2, LIF, LIFR, PRKCD, CCND1, CDKN2A
19
Show member pathways
8.5PPARG, GNAI2, LIF, LIFR, PRKCD, CDKN2A

Compounds for genes affiliated with Acth-Secreting Pituitary Adenoma

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Sources:
30IUPHAR, 62Tocris Bioscience, 12DrugBank, 46Novoseek, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1acetyl-podocarpic dimer3010.2NR1H2, NR1H3
2gw39653010.2NR1H2, NR1H3
324(s)-hydroxycholesterol3010.2NR1H3, NR1H2
4t09013173010.2NR1H2, NR1H3
524(s), 25-epoxycholesterol3010.2NR1H2, NR1H3
6gw 3965 hydrochloride6210.1NR1H2, NR1H3
7fexaramine62 30 1212.1NR1H3, NR1H2
8lg 1007544610.0PPARG, NR1H2
9cyproteroneacetate469.9GHRL, NR3C1, NR1H2
10l-783483309.9NR1H3, PPARG, NR1H2
11progestins469.6NR1H2, NR3C1, CCND1, LIF
12thiazolidinedione469.6NR1H2, CCND1, PPARG
135 aminosalicylic acid469.6NR1H2, PPARG, GAPDH
14corticosterone46 62 2511.5LIF, NR1H2, GHRL, NR3C1, AVPR1B
15rosiglitazone30 46 52 25 1213.4NR1H2, CCND1, PPARG, GHRL
16cytarabine46 52 1211.3CDKN2A, LIF, GAPDH, GHRL
17depsipeptide469.3LIF, CCND1, CDKN2A
18wortmannin469.3PRKCD, GIP, LIF, CCND1, GHRL
19carbachol46 30 1211.3NR3C1, GHRL, LIF, PRKCD, CCND1
20deoxyribonucleic acid469.3GAPDH, LIF, CDKN2A
21vitamin d469.2GHRL, NR1H2, NR3C1, NR1H3, PPARG
22progestin469.1LIF, CCND1, NR3C1, NR1H2, GAPDH
23arginine469.0LIF, GHRL, NR1H2, CDKN2A, GIP, AVPR1B
24arsenite46 2510.0CCND1, CDKN2A, GAPDH, NR1H2
25mg 13246 629.9CDKN2A, NR1H2, NR3C1, GAPDH, CCND1
26hydrocortisone46 3 62 1211.9CRHBP, NR1H2, GHRL, LIF, NR3C1
27genistein46 30 62 3 25 1213.9LIF, NR1H2, PPARG, CCND1, CDKN2A
28retinoid468.9CCND1, GAPDH, NR1H2, NR3C1, PPARG
29tacrolimus46 52 1210.8PPARG, CCND1, GAPDH, NR3C1
30dopamine46 30 25 1211.8NR3C1, NR1H2, CDKN2A, GAPDH, GHRL, LIF
31prostaglandin468.7PPARG, LIF, GHRL, CRHBP
32steroid468.7NR3C1, CDKN2A, LIFR, CCND1, NR1H3, NR1H2
33fatty acid468.6PPARG, LIF, GHRL, NR1H3, NR1H2, CDKN2A
34rapamycin468.6PRKCD, CCND1, NR1H3, PPARG, GAPDH, NR3C1
35acth468.5AVPR1B, LIF, LIFR, GHRL, NR3C1, TBX19
36estradiol46 25 1210.5GHRL, CCND1, CRHBP, NR1H2, NR3C1, LIF
37creatinine468.5GHRL, GIP, LIF, GAPDH, CDKN2A
38cisplatin46 52 62 1211.4CDKN2A, GAPDH, NR3C1, GHRL, CCND1, PRKCD
39cholesterol46 30 25 1211.4PRKCD, GHRL, LIFR, NR1H2, LIF, PPARG
40cycloheximide468.2CDKN2A, GAPDH, PPARG, PRKCD, LIF, CCND1
41progesterone46 30 62 25 1212.1CCND1, LIF, CRHBP, NR3C1, NR1H2, LIFR
42lipid468.1GHRL, PPARG, LIF, GIP, LIFR, CDKN2A
43alanine468.1GHRL, NR1H2, GAPDH, CDKN2A, PRKCD, LIFR
44serine468.0NR1H2, NR3C1, CCND1, PRKCD, GAPDH, GHRL
45dexamethasone46 52 30 1211.0PPARG, LIF, GHRL, NR3C1, NR1H2, CDKN2A
46testosterone46 62 25 1211.0NR3C1, NR1H2, CDKN2A, LIF, PPARG, GAPDH
47retinoic acid46 259.0NR1H2, LIF, PPARG, CDKN2A, GAPDH, NR3C1
48vegf468.0CDKN2A, GHRL, GAPDH, NR1H2, NR3C1, PPARG
49glucose467.9PPARG, LIF, PRKCD, GAPDH, GHRL, NR1H3
50estrogen466.6CCND1, PPARG, LIF, LIFR, PRKCD, GHRL

GO Terms for genes affiliated with Acth-Secreting Pituitary Adenoma

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17Gene Ontology
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Cellular components related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0GHRL, GIP
2nucleoplasmGO:0056547.9PPARG, PRKCD, CCND1, NR1H3, NR3C1, NR1H2
3cytosolGO:0058297.3PPARG, AIP, GNAI2, PRKCD, CCND1, NR3C1
4nucleusGO:0056346.0CDKN2A, PPARG, AIP, GNAI2, PRKCD, CCND1

Biological processes related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol transportGO:03237610.3NR1H3, NR1H2
2leukemia inhibitory factor signaling pathwayGO:04886110.3LIF, LIFR
3negative regulation of pinocytosisGO:04855010.3NR1H2, NR1H3
4negative regulation of lipid transportGO:03236910.3NR1H3, NR1H2
5regulation of cholesterol homeostasisGO:200018810.2NR1H2, NR1H3
6positive regulation of fatty acid biosynthetic processGO:04572310.2NR1H2, NR1H3
7positive regulation of lipoprotein lipase activityGO:05100610.2NR1H3, NR1H2
8positive regulation of triglyceride biosynthetic processGO:01086710.2NR1H3, NR1H2
9response to lipidGO:03399310.1GIP, PPARG
10positive regulation of cholesterol effluxGO:01087510.1NR1H2, NR1H3
11positive regulation of cellular protein metabolic processGO:03227010.1NR1H3, NR1H2
12decidualizationGO:04669710.1GHRL, LIF
13triglyceride homeostasisGO:07032810.0GIP, NR1H3
14negative regulation of proteolysisGO:0458619.9NR1H2, NR1H3
15negative regulation of inflammatory responseGO:0507289.9PRKCD, GHRL, NR1H3
16negative regulation of interferon-gamma-mediated signaling pathwayGO:0603369.9PPARG, NR1H3, NR1H2
17negative regulation of cholesterol storageGO:0108879.9PPARG, NR1H3, NR1H2
18negative regulation of macrophage derived foam cell differentiationGO:0107459.9PPARG, NR1H2, NR1H3
19lipid homeostasisGO:0550889.8PPARG, NR1H3
20response to estrogenGO:0436279.7PPARG, CCND1, GHRL
21G-protein coupled receptor signaling pathwayGO:0071869.5AVPR1B, PPARG, GNAI2, GHRL
22transcription initiation from RNA polymerase II promoterGO:0063679.5NR1H2, NR1H3, PPARG, NR3C1
23protein stabilizationGO:0508219.5CDKN2A, GAPDH, PRKCD
24cellular senescenceGO:0903989.4CDKN2A, PRKCD
25hormone-mediated signaling pathwayGO:0097559.3CRHBP, GHRL
26gene expressionGO:0104679.0NR1H3, NR3C1, PPARG, PRKCD, NR1H2
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.9PPARG, LIF, CDKN2A, NR1H2, NR1H3, TBX19
28signal transductionGO:0071658.3AIP, PPARG, NR3C1, CRHBP, PRKCD, GIP

Molecular functions related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5PPARG, NR1H3, NR1H2
2steroid hormone receptor activityGO:0037079.5NR1H2, PPARG, NR1H3
3retinoid X receptor bindingGO:0469659.4NR1H2, PPARG
4sequence-specific DNA bindingGO:0435659.2NR3C1, NR1H3, PPARG, NR1H2
5protein bindingGO:0055156.2PPARG, AIP, GNAI2, PRKCD, CCND1, CRHBP

Products for genes affiliated with Acth-Secreting Pituitary Adenoma

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Sources for Acth-Secreting Pituitary Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet