MCID: ACT010
MIFTS: 66

Acth-Secreting Pituitary Adenoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Acth-Secreting Pituitary Adenoma

About this section
Sources:
8Disease Ontology, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A functioning pituitary adenoma that characterized by excess cortisol a primary cause of cushing's syndrome.

MalaCards: Acth-Secreting Pituitary Adenoma, also known as pituitary adenoma, acth-secreting, is related to pituitary adenoma and adenoma, and has symptoms including facial pain/cephalalgia/migraine, epigastralgia/heartburn/gastric/duodenal ulcer/gastritis and onyxis/paronyxis/ungual inflammation. An important gene associated with Acth-Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) and Development A3 receptor signaling. The drugs aminoglutethimide and mitotane and the compounds 24(s), 25-epoxycholesterol and acetyl-podocarpic dimer have been mentioned in the context of this disorder. Affiliated tissues include pituitary, skin and bone, and related mouse phenotypes are nervous system and skeleton.

Description from OMIM:46 219090

Aliases & Classifications for Acth-Secreting Pituitary Adenoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 9diseasecard, 46OMIM, 48Orphanet, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
pituitary corticotroph micro-adenoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

acth-secreting pituitary adenoma 8 10 60
pituitary adenoma, acth-secreting 9 46
pituitary acth-secreting adenoma 9 46
pituitary-dependent cushing's disease 60
pituitary corticotroph micro-adenoma 48
pituitary dependent cushing syndrome 48
acth-producing pituitary adenoma 8
corticotroph pituitary adenoma 48
corticotroph adenoma 8
corticotropinoma 8
cushing syndrome 60
cushing disease 48


External Ids:

Disease Ontology8 DOID:7004
MeSH34 D049913
NCIt39 C7462
OMIM46 219090
MESH via Orphanet35 D047748
SNOMED-CT56 254958004, 21109002
ICD10 via Orphanet26 E24.0
SNOMED-CT via Orphanet57 190502001
UMLS via Orphanet61 C0221406
ICD1025 E24.0

Related Diseases for Acth-Secreting Pituitary Adenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acth-Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.4NR3C1, GHRL, GAPDH, PPARG, TBX19, LIF
2adenoma31.4AVPR1B, CDKN2A, AIP, LIFR, LIF, TBX19
3cushing's syndrome30.4AVPR1B, GIP, NR3C1, GHRL, CRHBP
4leukemia30.4CCND1, GAPDH, NR1H2, NR3C1, LIF, LIFR
5addison's disease30.4NR1H2, CRHBP
6meningioma30.3GAPDH
7nelson syndrome30.2NR3C1, PPARG
8lung cancer30.1CCND1, CDKN2A
9pheochromocytoma29.8LIF
10psoriasis29.8NR1H2
11hypertension29.8NR3C1, PPARG
12hypoglycemia29.8GIP, GHRL
13diabetes mellitus29.8PPARG, GAPDH, GHRL, NR3C1, GIP
14obesity29.8PPARG, GAPDH, GHRL, NR1H2, NR3C1, LIF
15prostate cancer29.8CCND1, PPARG, GAPDH, GHRL, PRKCD, NR1H2
16cushing syndrome due to ectopic acth secretion10.4
17adrenocortical carcinoma10.3
18pigmentation disease10.3
19adrenal adenoma10.3
20functioning pituitary adenoma10.3
21mccune albright syndrome10.3
22acromegaly10.2
23pituitary hypoplasia10.1
24craniopharyngioma10.1
25lung adenoma10.1
26pituitary cancer10.1
27pituitary-dependent cushing's disease10.1
28congenital adrenal hyperplasia10.1
29nephrocalcinosis10.1
30adrenal carcinoma10.1
31leydig cell tumor10.1
32spasmodic dysphonia10.1
33cushing syndrome, familial10.1
34pigmented nodular adrenocortical disease, primary, 210.1
35malignant acth producing neoplasm of pituitary gland10.0
36peritonitis10.0LIF
37endometriosis10.0LIF
38morbid obesity10.0GHRL
39liposarcoma10.0PPARG
40hepatitis b10.0AIP
41sarcoma10.0GAPDH
42myeloid leukemia10.0LIF, NR1H2
43fatty liver disease10.0PPARG
44coronary heart disease10.0NR1H3, NR3C1
45cervical adenocarcinoma10.0CDKN2A
46hypopituitarism10.0GHRL, CRHBP
47anaplastic astrocytoma10.0CDKN2A
48plasmacytoma10.0LIF, LIFR
49eating disorder10.0GHRL
50hepatoblastoma10.0LIF, NR1H2

Graphical network of the top 20 diseases related to Acth-Secreting Pituitary Adenoma:



Diseases related to acth-secreting pituitary adenoma

Clinical Features for Acth-Secreting Pituitary Adenoma

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

219090

Clinical synopsis from OMIM:

219090

Symptoms:

48 (show all 40)
  • facial pain/cephalalgia/migraine
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • onyxis/paronyxis/ungual inflammation
  • telangiectasiae of the skin
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • chronic skin infection/ulcerations/ulcers/cancrum
  • mild visual loss/impaired visual acuity
  • acute abdominal pain/colic
  • cardiomyopathy/hypertrophic/dilated
  • venous thrombosis/phlebitis/thrombophlebitis
  • precocious menopause/secondary amenorrhea
  • sleep and vigilance disorders
  • obnubilation/coma/lethargia/desorientation
  • psychosis/schizophrenia/maniac disorder
  • myopathy
  • osteonecrosis/bone infarction
  • visual loss/blindness/amblyopia
  • cataract/lens opacification
  • asthenia/fatigue/weakness
  • hirsutism/hypertrichosis/increased body hair
  • acne/acnea
  • cushingoid morphotype
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • abnormal fat distribution/lipodystrophy
  • truncal obesity
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • cortico-adrenal hyperplasia/hypersecretion
  • thin skin
  • chronic arterial hypertension
  • bruisability
  • hypokalemia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • mutiple fractures/bone fragility
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • diabetes mellitus
  • sterility/hypofertility
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • round face

Drugs & Therapeutics for Acth-Secreting Pituitary Adenoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acth-Secreting Pituitary Adenoma

Drug clinical trials:

Search ClinicalTrials for Acth-Secreting Pituitary Adenoma

Search NIH Clinical Center for Acth-Secreting Pituitary Adenoma

Search CenterWatch for Acth-Secreting Pituitary Adenoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acth-Secreting Pituitary Adenoma

About this section

Anatomical Context for Acth-Secreting Pituitary Adenoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Acth-Secreting Pituitary Adenoma:

32
Pituitary, Skin, Bone, Kidney, Liver

Animal Models for Acth-Secreting Pituitary Adenoma or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Acth-Secreting Pituitary Adenoma

About this section
Sources:
50PubMed
See all sources

Articles related to Acth-Secreting Pituitary Adenoma:

(show all 27)
idTitleAuthorsYear
1
Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells. (23667519)
2013
2
miR-26a plays an important role in cell cycle regulation in ACTH-secreting pituitary adenomas by modulating protein kinase CI'. (23525216)
2013
3
Nasally located ectopic ACTH-secreting pituitary adenoma (EAPA) causing Nelson's syndrome: diagnostic challenges. (24065616)
2013
4
Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. (24379119)
2013
5
Pituitary ACTH-secreting adenoma in Addison's disease: a case report. (24216004)
2013
6
Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma, absence of stigmata of Cushing's syndrome and unusual histologic features. (22570980)
2012
7
Visual vignette. Ectopic ACTH-secreting pituitary adenoma. (21803709)
2011
8
ICA Occlusion by an ACTH-secreting pituitary adenoma post-TSS and irradiation. (22399870)
2011
9
Liver X receptor-I+/I^ expression ratio is increased in ACTH-secreting pituitary adenomas. (21356276)
2011
10
An ACTH-secreting pituitary adenoma within the sphenoid sinus. (20424367)
2010
11
Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas. (20616110)
2010
12
Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. (20719856)
2010
13
Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas. (19318729)
2009
14
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
15
A patient with recurrent hypercortisolism after removal of an ACTH-secreting pituitary adenoma due to an adrenal macronodule. (17185905)
2006
16
ACTH-secreting pituitary adenoma within an ovarian teratoma. (16137552)
2005
17
Mutation analysis of leukemia inhibitory factor-receptor (LIF-R) in ACTH-secreting pituitary adenomas. (15372367)
2004
18
Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. (12379847)
2002
19
Decreased expression of corticotropin-releasing factor-binding protein mRNA in ACTH-secreting pituitary adenomas. (10768834)
2000
20
Significant gene expression of insulin-like growth factor II and proliferating cell nuclear antigen in a rapidly growing recurrent pituitary acth-secreting adenoma. (11416238)
2000
21
Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. (10926317)
2000
22
Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine. (7508871)
1994
23
Mass spectrometric analysis of opioid and tachykinin neuropeptides in non-secreting and ACTH-secreting human pituitary adenomas. (8381675)
1993
24
Vasopressin enhances a calcium current in human ACTH-secreting pituitary adenoma cells. (2844618)
1988
25
Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. (6326445)
1984
26
Increase of beta-endorphin in cerebrospinal fluid after removal of ACTH-secreting pituitary adenoma. (6272176)
1981
27
ACTH secreting pituitary adenoma in an infant of 18 months. Immunohistochemical, electron-microscopic, and in-vitro studies. (6278457)
1981

Genetic Variations for Acth-Secreting Pituitary Adenoma

About this section

Expression for genes affiliated with Acth-Secreting Pituitary Adenoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acth-Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Acth-Secreting Pituitary Adenoma.

Pathways for genes affiliated with Acth-Secreting Pituitary Adenoma

About this section
Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Pathways related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0GHRL, GIP
2
Development A3 receptor signaling
Hide members
9.5CCND1, GNAI2, PRKCD
3
Hide members
9.5CCND1, GNAI2, PRKCD
4
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.3LIFR, PRKCD, PPARG
59.3LIFR, LIF, NR1H3, PPARG
6
Hide members
9.3GNAI2, PRKCD, LIF, LIFR
79.3CDKN2A, PRKCD, CCND1
8
Hide members
9.2GNAI2, GHRL, NR3C1, GIP, AVPR1B
9
Hide members
9.2PPARG, NR1H2, NR3C1, NR1H3
10
Hide members
9.0LIFR, LIF, NR3C1, PRKCD, GNAI2
11
Hide members
9.0LIFR, LIF, PRKCD, GNAI2, CCND1
12
Hide members
8.8CDKN2A, LIFR, PRKCD, GNAI2, CCND1
13
Hide members
8.6CCND1, GNAI2, PRKCD, LIF, LIFR, CDKN2A
14
Hide members
8.5CDKN2A, LIFR, LIF, PRKCD, PPARG, GNAI2

Compounds for genes affiliated with Acth-Secreting Pituitary Adenoma

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
124(s), 25-epoxycholesterol2810.3NR1H3, NR1H2
2acetyl-podocarpic dimer2810.3NR1H3, NR1H2
3t09013172810.3NR1H2, NR1H3
4gw39652810.3NR1H3, NR1H2
524(s)-hydroxycholesterol2810.3NR1H3, NR1H2
6estradiol44 11 2412.2CRHBP
7gw 3965 hydrochloride5910.2NR1H2, NR1H3
8t 09013175910.2NR1H3, NR1H2
9fexaramine59 28 1112.2NR1H2, NR1H3
10lg 1007544410.1PPARG, NR1H2
11estrogen4410.0LIFR, CRHBP
12l-7834832810.0NR1H3, NR1H2, PPARG
13N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE1110.0NR1H3, NR1H2
14cyproteroneacetate449.9NR1H2, NR3C1, GHRL
15thiazolidinedione449.7PPARG, NR1H2, CCND1
16progestins449.7LIF, CCND1, NR1H2, NR3C1
17depsipeptide449.7LIF, CCND1, CDKN2A
18corticosterone44 59 2411.6NR1H2, GHRL, NR3C1, LIF, AVPR1B
19rosiglitazone44 49 28 11 2413.4GHRL, CCND1, PPARG, NR1H2
205 aminosalicylic acid449.3GAPDH, PPARG, NR1H2
21carbachol44 28 1111.2LIF, NR3C1, PRKCD, GHRL, CCND1
22wortmannin449.2GIP, LIF, PRKCD, GHRL, CCND1
23vitamin d449.2NR1H3, GHRL, NR1H2, NR3C1, PPARG
24prostaglandin449.2CRHBP, PPARG, GHRL
25hydrocortisone44 2 59 1112.1NR1H2, GHRL, NR3C1, LIF, CRHBP
26steroid449.1CCND1, NR1H2, NR1H3, LIF, LIFR, CDKN2A
27cytarabine44 49 1111.1LIF, CDKN2A, GAPDH, GHRL
28serine449.1NR1H2, PRKCD, CCND1, GHRL, LIF
29genistein44 28 59 2 11 2414.0PPARG, CDKN2A, NR1H2, CCND1, LIF
30progestin448.9GAPDH, NR1H2, NR3C1, LIF, CCND1
31dopamine44 28 11 2411.9GAPDH, NR1H2, LIF, GHRL, NR3C1
32arginine448.8GIP, NR1H2, AVPR1B, GHRL, CDKN2A, LIF
33arsenite44 249.8CDKN2A, GAPDH, NR1H2, CCND1
34deoxyribonucleic acid448.8CDKN2A, GAPDH, LIF
35mg 13244 599.7CCND1, GAPDH, NR1H2, CDKN2A, NR3C1
36dexamethasone44 49 28 1111.7CRHBP, NR1H2, NR3C1, LIF, CDKN2A, GHRL
37acth448.7AVPR1B, LIFR, LIF, CRHBP, TBX19, NR3C1
38retinoid448.7GAPDH, NR3C1, CCND1, NR1H2, PPARG
39fatty acid448.6PPARG, CDKN2A, NR1H3, NR1H2, PRKCD, LIF
40tacrolimus44 49 1110.6PPARG, CCND1, NR3C1, GAPDH
41progesterone44 59 28 11 2412.4CDKN2A, NR1H2, CCND1, CRHBP, NR3C1, LIF
42cholesterol44 28 11 2411.4PPARG, GHRL, PRKCD, LIFR, CDKN2A, NR1H3
43glucose448.3GIP, GHRL, PPARG, GAPDH, NR1H3, LIF
44rapamycin448.3PPARG, CCND1, NR1H3, NR3C1, PRKCD, GAPDH
45lipid448.1PRKCD, CDKN2A, GIP, NR1H3, NR1H2, PPARG
46cisplatin44 49 59 1111.1PRKCD, CDKN2A, LIF, NR3C1, GHRL, GAPDH
47retinoic acid44 248.8CDKN2A, NR1H3, NR3C1, NR1H2, GAPDH, PPARG
48testosterone44 59 11 2410.8NR1H2, GAPDH, PPARG, CCND1, LIF, GHRL
49vegf447.8CDKN2A, LIF, NR3C1, PPARG, NR1H2, GHRL
50alanine447.8PPARG, PRKCD, NR1H2, LIFR, GIP, GAPDH

GO Terms for genes affiliated with Acth-Secreting Pituitary Adenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0GIP, GHRL
2nucleoplasmGO:0056547.9CDKN2A, CCND1, PPARG, PRKCD, NR1H2, NR3C1
3nucleusGO:0056345.6CCND1, GNAI2, PPARG, GAPDH, CRHBP, PRKCD

Biological processes related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of pinocytosisGO:04855010.3NR1H3, NR1H2
2leukemia inhibitory factor signaling pathwayGO:04886110.3LIF, LIFR
3positive regulation of cholesterol transportGO:03237610.2NR1H3, NR1H2
4negative regulation of lipid transportGO:03236910.2NR1H2, NR1H3
5positive regulation of fatty acid biosynthetic processGO:04572310.1NR1H3, NR1H2
6positive regulation of lipoprotein lipase activityGO:05100610.1NR1H2, NR1H3
7positive regulation of triglyceride biosynthetic processGO:01086710.0NR1H2, NR1H3
8negative regulation of interferon-gamma-mediated signaling pathwayGO:0603369.9NR1H3, NR1H2, PPARG
9negative regulation of cholesterol storageGO:0108879.9NR1H3, NR1H2, PPARG
10negative regulation of macrophage derived foam cell differentiationGO:0107459.9PPARG, NR1H2, NR1H3
11positive regulation of cholesterol effluxGO:0108759.9NR1H2, NR1H3
12negative regulation of inflammatory responseGO:0507289.7GHRL, PRKCD, NR1H3
13positive regulation of cellular protein metabolic processGO:0322709.7NR1H3, NR1H2
14response to estrogen stimulusGO:0436279.6GHRL, PPARG, CCND1
15transcription initiation from RNA polymerase II promoterGO:0063679.5PPARG, NR1H2, NR3C1, NR1H3
16response to drugGO:0424939.1GIP, PRKCD, PPARG, CCND1
17protein stabilizationGO:0508219.0CDKN2A, PRKCD, GAPDH
18positive regulation of transcription from RNA polymerase II promoterGO:0459448.9PPARG, NR1H2, NR1H3, TBX19, LIF, CDKN2A
19gene expressionGO:0104678.8NR1H3, NR3C1, NR1H2, PRKCD, PPARG
20signal transductionGO:0071658.4GNAI2, PPARG, CRHBP, PRKCD, NR3C1, AIP

Molecular functions related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinoid X receptor bindingGO:0469659.8NR1H2, PPARG
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.4NR1H3, NR1H2, PPARG
3steroid hormone receptor activityGO:0037079.2NR1H3, NR1H2, PPARG

Products for genes affiliated with Acth-Secreting Pituitary Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acth-Secreting Pituitary Adenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet