MCID: ACT010
MIFTS: 68

Acth-Secreting Pituitary Adenoma malady

Endocrine diseases, Reproductive diseases, Cancer diseases, Rare diseases categories
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Summaries for Acth-Secreting Pituitary Adenoma

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Disease Ontology:8 A functioning pituitary adenoma that characterized by excess cortisol a primary cause of cushing's syndrome.

MalaCards based summary: Acth-Secreting Pituitary Adenoma, also known as pituitary adenoma, acth-secreting, is related to cushing's syndrome and nelson syndrome, and has symptoms including round face, thin skin and cortico-adrenal hyperplasia/hypersecretion. An important gene associated with Acth-Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Serotonin Receptor 4/6/7 and NR3C Signaling and G alpha (s) signalling events. The drugs aminoglutethimide and mitotane and the compounds gw3965 and t0901317 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, skin and bone, and related mouse phenotypes are adipose tissue and tumorigenesis.

Description from OMIM:46 219090

Aliases & Classifications for Acth-Secreting Pituitary Adenoma

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 48Orphanet, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Acth-Secreting Pituitary Adenoma, Aliases & Descriptions:

Name: Acth-Secreting Pituitary Adenoma 8 10 62
Pituitary Adenoma, Acth-Secreting 9 46
Pituitary Acth-Secreting Adenoma 9 46
Cushing Disease 48 62
Pituitary-Dependent Cushing's Disease 62
Pituitary Dependent Cushing Syndrome 48
 
Pituitary Corticotroph Micro-Adenoma 48
Acth-Producing Pituitary Adenoma 8
Corticotroph Pituitary Adenoma 48
Corticotroph Adenoma 8
Corticotropinoma 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
cushing disease:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:7004
NCIt39 C7462
MeSH34 D049913
OMIM46 219090
SNOMED-CT57 254958004, 21109002
MESH via Orphanet35 D047748
ICD10 via Orphanet26 E24.0
UMLS via Orphanet63 C0221406
ICD1025 E24.0

Related Diseases for Acth-Secreting Pituitary Adenoma

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Diseases related to Acth-Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.9GIP, NR3C1
2nelson syndrome30.6NR3C1, PPARG
3acromegaly30.6GHRL, GNAS, AIP
4pituitary adenoma30.5PPARG, AIP, GNAS, LIF, LIFR, GHRL
5acth-independent macronodular adrenal hyperplasia30.5GNAS
6adenoma30.1GNAS, AIP, PPARG, AVPR1B, LIF, LIFR
7pituitary tumors29.9PPARG, AIP, GNAS, LIF, GHRL, NR1H2
8leukemia29.9LIF, LIFR, CCND1, NR3C1, NR1H2, GAPDH
9obesity28.7PPARG, GNAS, GIP, LIF, GHRL, NR3C1
10addison's disease10.3
11meningioma10.3
12familial glucocorticoid deficiency10.3
13esophageal cancer10.3CDKN2A, CCND1
14gigantism10.3GNAS, AIP
15carney complex10.2AIP, GNAS
16embryonal cancer10.2LIF, LIFR, NR1H2
17malignant acth producing neoplasm of pituitary gland10.2
18adrenal gland hyperfunction10.2NR3C1, GHRL
19glucose intolerance10.2PPARG, GHRL, NR3C1
20craniopharyngioma10.2
21lung cancer10.2
22x-linked adrenal hypoplasia congenita10.2
23choristoma10.2
24polycystic ovary syndrome10.2PPARG, GHRL, NR1H2
25familial hyperlipidemia10.2PPARG, LIF, NR3C1
26carcinoid syndrome10.2AVPR1B, GNAS, GHRL
27pituitary-dependent cushing's disease10.1
28squamous cell carcinoma of the head and neck10.1CCND1, NR1H2, CDKN2A
29osteoporosis10.1LIF, NR3C1, NR1H2
30arthritis10.1LIF, LIFR, GHRL, NR1H2
31hyperinsulinism10.1NR1H2, GHRL, PPARG
32papilloma10.1CDKN2A, GAPDH, NR1H2
33hyperandrogenism10.1PPARG, GNAS, NR3C1
34parathyroid adenoma10.1GNAS, CCND1
35infertility10.1LIF, LIFR, NR1H2, GAPDH
36metabolic syndrome x10.1NR1H2, NR3C1, GHRL, PPARG
37choriocarcinoma10.0PPARG, LIF, LIFR, GAPDH
38follicular adenoma10.0PPARG, GNAS, GAPDH
39non-small cell lung carcinoma10.0CDKN2A, CCND1, PPARG
40myeloma10.0LIF, LIFR, PRKCD, CCND1, NR3C1
41papillary carcinoma10.0GAPDH, GNAS, PPARG
42atherosclerosis10.0PPARG, LIF, GHRL, NR1H3, NR1H2
43thyroid hurthle cell carcinoma10.0PPARG, GNAS, GAPDH
44deficiency anemia10.0GAPDH, GHRL, LIF, GNAS
45galactosemia9.9PPARG, NR3C1, NR1H2, GAPDH
46viral infectious disease9.9LIF, NR3C1, NR1H2, GAPDH
47lung adenocarcinoma9.9PRKCD, CCND1, GAPDH, CDKN2A
48sinusitis9.9
49growth hormone secreting pituitary adenoma9.9
50hypoglycemia9.9

Graphical network of the top 20 diseases related to Acth-Secreting Pituitary Adenoma:



Diseases related to acth-secreting pituitary adenoma

Symptoms for Acth-Secreting Pituitary Adenoma

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Symptoms by clinical synopsis from OMIM:

219090

Clinical features from OMIM:

219090

Symptoms:

48 (show all 40)
  • round face
  • thin skin
  • cortico-adrenal hyperplasia/hypersecretion
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • truncal obesity
  • abnormal fat distribution/lipodystrophy
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • cushingoid morphotype
  • acne/acnea
  • hirsutism/hypertrichosis/increased body hair
  • chronic arterial hypertension
  • bruisability
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • sterility/hypofertility
  • diabetes mellitus
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • mutiple fractures/bone fragility
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hypokalemia
  • asthenia/fatigue/weakness
  • cataract/lens opacification
  • visual loss/blindness/amblyopia
  • mild visual loss/impaired visual acuity
  • chronic skin infection/ulcerations/ulcers/cancrum
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • telangiectasiae of the skin
  • onyxis/paronyxis/ungual inflammation
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • cardiomyopathy/hypertrophic/dilated
  • venous thrombosis/phlebitis/thrombophlebitis
  • precocious menopause/secondary amenorrhea
  • facial pain/cephalalgia/migraine
  • sleep and vigilance disorders
  • obnubilation/coma/lethargia/desorientation
  • psychosis/schizophrenia/maniac disorder
  • myopathy
  • osteonecrosis/bone infarction

HPO human phenotypes related to Acth-Secreting Pituitary Adenoma:

(show all 56)
id Description Frequency HPO Source Accession
1 round face hallmark (90%) HP:0000311
2 thin skin hallmark (90%) HP:0000963
3 hypercortisolism hallmark (90%) HP:0001578
4 truncal obesity hallmark (90%) HP:0001956
5 abnormality of adipose tissue hallmark (90%) HP:0009124
6 neoplasm of the endocrine system hallmark (90%) HP:0100568
7 decreased fertility typical (50%) HP:0000144
8 nephrolithiasis typical (50%) HP:0000787
9 diabetes mellitus typical (50%) HP:0000819
10 hypertension typical (50%) HP:0000822
11 bruising susceptibility typical (50%) HP:0000978
12 hypertrichosis typical (50%) HP:0000998
13 acne typical (50%) HP:0001061
14 recurrent fractures typical (50%) HP:0002757
15 hypokalemia typical (50%) HP:0002900
16 reduced bone mineral density typical (50%) HP:0004349
17 abnormality of immune system physiology typical (50%) HP:0010978
18 visual impairment occasional (7.5%) HP:0000505
19 cataract occasional (7.5%) HP:0000518
20 secondary amenorrhea occasional (7.5%) HP:0000869
21 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
22 paronychia occasional (7.5%) HP:0001818
23 abdominal pain occasional (7.5%) HP:0002027
24 migraine occasional (7.5%) HP:0002076
25 sleep disturbance occasional (7.5%) HP:0002360
26 myopathy occasional (7.5%) HP:0003198
27 abnormality of the gastric mucosa occasional (7.5%) HP:0004295
28 reduced consciousness/confusion occasional (7.5%) HP:0004372
29 thrombophlebitis occasional (7.5%) HP:0004418
30 generalized hyperpigmentation occasional (7.5%) HP:0007440
31 aseptic necrosis occasional (7.5%) HP:0010885
32 teleangiectasia of the skin occasional (7.5%) HP:0100585
33 skin ulcer occasional (7.5%) HP:0200042
34 nephrolithiasis HP:0000787
35 hypertension HP:0000822
36 glucose intolerance HP:0000833
37 oligomenorrhea HP:0000876
38 osteoporosis HP:0000939
39 thin skin HP:0000963
40 edema HP:0000969
41 bruising susceptibility HP:0000978
42 purpura HP:0000979
43 hirsutism HP:0001007
44 facial erythema HP:0001041
45 poor wound healing HP:0001058
46 striae distensae HP:0001065
47 psychotic mentation HP:0001345
48 obesity HP:0001513
49 alkalosis HP:0001948
50 kyphosis HP:0002808
51 hypokalemia HP:0002900
52 vertebral compression fractures HP:0002953
53 increased circulating acth level HP:0003154
54 amyotrophy HP:0003202
55 biconcave vertebral bodies HP:0004586
56 abnormal fear/anxiety-related behavior HP:0100852

Drugs & Therapeutics for Acth-Secreting Pituitary Adenoma

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Drug clinical trials:

Search ClinicalTrials for Acth-Secreting Pituitary Adenoma

Search NIH Clinical Center for Acth-Secreting Pituitary Adenoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Acth-Secreting Pituitary Adenoma

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Anatomical Context for Acth-Secreting Pituitary Adenoma

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MalaCards organs/tissues related to Acth-Secreting Pituitary Adenoma:

32
Pituitary, Skin, Bone, Kidney, Liver

Animal Models for Acth-Secreting Pituitary Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Acth-Secreting Pituitary Adenoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9PPARG, GNAS, LIF, GHRL, NR3C1
2MP:00020068.8CDKN2A, CCND1, GNAI2, AIP, PPARG
3MP:00053818.6GNAI2, GIP, LIF, CCND1, GHRL, NR3C1
4MP:00053888.4GNAS, GNAI2, LIF, CCND1, NR3C1, CDKN2A
5MP:00028738.3PPARG, GNAS, CCND1, GHRL, NR1H3, NR3C1
6MP:00053698.1PPARG, GNAS, LIF, PRKCD, NR1H3, NR3C1
7MP:00053898.0PPARG, LIF, CCND1, NR1H3, NR3C1, NR1H2
8MP:00107717.9PPARG, AIP, GNAS, LIF, CCND1, NR3C1
9MP:00053907.6LIF, GNAI2, GNAS, PPARG, LIFR, PRKCD
10MP:00053847.5PPARG, GNAS, GNAI2, LIF, PRKCD, CCND1
11MP:00053707.3PPARG, AIP, GNAS, GNAI2, LIF, PRKCD
12MP:00053857.3PPARG, AIP, GNAS, GNAI2, LIF, PRKCD
13MP:00053877.3PPARG, GNAS, GNAI2, LIF, LIFR, PRKCD
14MP:00036316.9AVPR1B, PPARG, GNAS, GNAI2, LIF, LIFR
15MP:00053976.9LIFR, LIF, GNAI2, GNAS, PPARG, PRKCD
16MP:00053796.8CDKN2A, AVPR1B, PPARG, AIP, GNAS, GNAI2
17MP:00053866.7LIF, GNAI2, GNAS, PPARG, AVPR1B, CCND1
18MP:00107686.6LIF, GNAI2, GNAS, AIP, PPARG, LIFR
19MP:00053786.0LIF, GIP, GNAI2, GNAS, AIP, PPARG
20MP:00053765.8LIF, GIP, GNAI2, GNAS, AIP, PPARG

Publications for Acth-Secreting Pituitary Adenoma

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Articles related to Acth-Secreting Pituitary Adenoma:

(show all 21)
idTitleAuthorsYear
1
Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells. (23667519)
2013
2
miR-26a plays an important role in cell cycle regulation in ACTH-secreting pituitary adenomas by modulating protein kinase CI'. (23525216)
2013
3
Nasally located ectopic ACTH-secreting pituitary adenoma (EAPA) causing Nelson's syndrome: diagnostic challenges. (24065616)
2013
4
Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. (24379119)
2013
5
Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma, absence of stigmata of Cushing's syndrome and unusual histologic features. (22570980)
2012
6
Visual vignette. Ectopic ACTH-secreting pituitary adenoma. (21803709)
2011
7
ICA Occlusion by an ACTH-secreting pituitary adenoma post-TSS and irradiation. (22399870)
2011
8
Liver X receptor-I+/I^ expression ratio is increased in ACTH-secreting pituitary adenomas. (21356276)
2011
9
An ACTH-secreting pituitary adenoma within the sphenoid sinus. (20424367)
2010
10
Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas. (20616110)
2010
11
Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. (20719856)
2010
12
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
13
A patient with recurrent hypercortisolism after removal of an ACTH-secreting pituitary adenoma due to an adrenal macronodule. (17185905)
2006
14
Mutation analysis of leukemia inhibitory factor-receptor (LIF-R) in ACTH-secreting pituitary adenomas. (15372367)
2004
15
Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. (12379847)
2002
16
Decreased expression of corticotropin-releasing factor-binding protein mRNA in ACTH-secreting pituitary adenomas. (10768834)
2000
17
Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine. (7508871)
1994
18
Vasopressin enhances a calcium current in human ACTH-secreting pituitary adenoma cells. (2844618)
1988
19
Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. (6326445)
1984
20
Increase of beta-endorphin in cerebrospinal fluid after removal of ACTH-secreting pituitary adenoma. (6272176)
1981
21
ACTH secreting pituitary adenoma in an infant of 18 months. Immunohistochemical, electron-microscopic, and in-vitro studies. (6278457)
1981

Variations for Acth-Secreting Pituitary Adenoma

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Clinvar genetic disease variations for Acth-Secreting Pituitary Adenoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1GNAI2NM_002070.3(GNAI2): c.535C> G (p.Arg179Gly)single nucleotide variantPathogenicrs137853226GRCh37Chr 3, 50293694: 50293694
2GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
3GNASNM_001077488.2(GNAS): c.684G> C (p.Gln228His)single nucleotide variantPathogenicrs137854533GRCh37Chr 20, 57484597: 57484597
4AIPNM_003977.2(AIP): c.911G> A (p.Arg304Gln)single nucleotide variantPathogenicrs104894190GRCh37Chr 11, 67258382: 67258382

Expression for genes affiliated with Acth-Secreting Pituitary Adenoma

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Expression patterns in normal tissues for genes affiliated with Acth-Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Acth-Secreting Pituitary Adenoma.

Pathways for genes affiliated with Acth-Secreting Pituitary Adenoma

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Pathways related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GNAS, NR3C1
29.9GIP, GNAI2, GNAS
39.8LIFR, CCND1
4
Show member pathways
Signal transduction cAMP signaling60
9.7GNAS, GNAI2, PRKCD
5
Show member pathways
Type III interferon signaling37
9.6LIFR, CCND1, LIF
6
Show member pathways
9.6CCND1, PRKCD, GNAI2
7
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.6CCND1, PRKCD, GNAI2
8
Show member pathways
9.5GNAS, GNAI2, GIP, PRKCD
9
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.4NR3C1, CCND1, PRKCD
10
Show member pathways
9.4GNAI2, LIF, LIFR, PRKCD
11
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.4PPARG, LIFR, PRKCD
12
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.3PRKCD, CCND1, CDKN2A
139.3CDKN2A, CCND1, PRKCD
14
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.3CCND1, PRKCD, GNAI2, GNAS
15
Show member pathways
9.3PPARG, GNAS, GNAI2, PRKCD
16
Show member pathways
Nuclear Receptors37
9.2NR1H2, NR3C1, NR1H3, PPARG
17
Show member pathways
9.1AVPR1B, GNAS, GNAI2, PRKCD, CCND1
18
Show member pathways
9.1GNAI2, LIF, LIFR, PRKCD, NR3C1
19
Show member pathways
9.0AVPR1B, GNAS, GNAI2, GIP, GHRL, NR3C1
20
Show member pathways
9.0GNAI2, LIF, LIFR, PRKCD, CCND1
218.9PPARG, LIF, LIFR, NR1H3, NR3C1
22
Show member pathways
8.9CDKN2A, CCND1, PRKCD, LIFR, GNAI2
238.7TBX19, CRHBP, PRKCD, GNAI2, GNAS
24
Show member pathways
8.6AVPR1B, GNAS, GNAI2, GIP, PRKCD, CCND1
25
Show member pathways
8.6GNAI2, LIF, LIFR, PRKCD, CCND1, CDKN2A
26
Show member pathways
8.5PPARG, GNAI2, LIF, LIFR, PRKCD, CDKN2A

Compounds for genes affiliated with Acth-Secreting Pituitary Adenoma

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Compounds related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1gw39652810.2NR1H2, NR1H3
2t09013172810.2NR1H2, NR1H3
324(s), 25-epoxycholesterol2810.2NR1H2, NR1H3
4acetyl-podocarpic dimer2810.2NR1H2, NR1H3
524(s)-hydroxycholesterol2810.1NR1H2, NR1H3
6lg 1007544410.0NR1H2, PPARG
7gw 3965 hydrochloride619.9NR1H2, NR1H3
8l-783483289.9NR1H2, NR1H3, PPARG
9cyproteroneacetate449.9NR3C1, NR1H2, GHRL
10fexaramine61 28 1111.8NR1H2, NR1H3
11progestins449.6LIF, CCND1, NR1H2, NR3C1
125 aminosalicylic acid449.5PPARG, NR1H2, GAPDH
13corticosterone44 61 2411.5NR1H2, GHRL, LIF, AVPR1B, NR3C1
14thiazolidinedione449.5PPARG, CCND1, NR1H2
15histidine449.5CDKN2A, LIF, GHRL, GIP, GNAS
16deoxyribonucleic acid449.5CDKN2A, GAPDH, LIF, GNAS
17rosiglitazone28 44 50 24 1113.4GHRL, PPARG, NR1H2, CCND1
18cytarabine44 50 1111.3GHRL, GAPDH, CDKN2A, LIF
19wortmannin449.3LIF, PRKCD, GIP, GHRL, CCND1
20carbachol44 28 1111.3NR3C1, LIF, PRKCD, CCND1, GHRL
21vitamin d449.2NR1H2, NR3C1, GHRL, NR1H3, PPARG
22progestin449.1NR1H2, LIF, CCND1, NR3C1, GAPDH
23arginine449.0NR1H2, GHRL, CDKN2A, GIP, GNAS, AVPR1B
24mg 13244 619.9CDKN2A, NR3C1, GAPDH, NR1H2, CCND1
25hydrocortisone44 2 61 1111.9LIF, GHRL, CRHBP, NR3C1, NR1H2
26retinoid448.9CCND1, NR3C1, NR1H2, PPARG, GAPDH
27forskolin44 50 1110.8LIF, GNAS, GIP, GHRL, CRHBP
28genistein44 28 61 2 24 1113.7CDKN2A, NR1H2, CCND1, PPARG, LIF
29pge2448.7NR1H2, GAPDH, PPARG, GNAS, LIF
30oligonucleotide448.6CDKN2A, GAPDH, CCND1, LIFR, LIF, GNAS
31rapamycin448.6PRKCD, CCND1, NR1H3, NR3C1, GAPDH, PPARG
32fatty acid448.6CDKN2A, NR1H2, NR1H3, GHRL, LIF, PRKCD
33dopamine44 28 24 1111.6LIF, GHRL, GNAS, NR3C1, NR1H2, CDKN2A
34steroid448.5GNAS, LIF, LIFR, CCND1, NR1H3, NR3C1
35estradiol44 24 1110.5NR3C1, LIF, CCND1, GHRL, CRHBP, NR1H2
36cisplatin44 50 61 1111.4GHRL, NR3C1, CCND1, PRKCD, CDKN2A, GAPDH
37cholesterol44 28 24 1111.4LIF, PRKCD, GHRL, NR1H3, NR1H2, CDKN2A
38acth448.3TBX19, GNAS, NR3C1, LIF, AVPR1B, LIFR
39cycloheximide448.2PPARG, LIF, PRKCD, CCND1, NR3C1, GAPDH
40nitric oxide44 24 1110.2GNAS, GAPDH, GHRL, LIF, CDKN2A, PRKCD
41testosterone44 61 24 1111.0GAPDH, CDKN2A, LIF, CCND1, GHRL, PPARG
42dexamethasone44 50 28 1111.0PPARG, CDKN2A, LIF, GHRL, NR3C1, NR1H2
43retinoic acid44 249.0CDKN2A, NR1H3, GAPDH, NR1H2, NR3C1, PPARG
44vegf448.0CCND1, LIF, CDKN2A, GAPDH, NR1H2, NR3C1
45progesterone44 28 61 24 1112.0LIFR, CCND1, CRHBP, NR3C1, NR1H2, CDKN2A
46lipid448.0PRKCD, LIFR, PPARG, LIF, GIP, GNAS
47alanine447.9GIP, GNAS, GAPDH, PPARG, LIFR, PRKCD
48serine447.8CCND1, GNAS, NR3C1, NR1H2, PRKCD, LIF
49glucose447.7NR1H3, NR1H2, GAPDH, CDKN2A, PPARG, GNAS
50estrogen446.6NR1H2, PPARG, LIF, PRKCD, CCND1, GHRL

GO Terms for genes affiliated with Acth-Secreting Pituitary Adenoma

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Cellular components related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.7GIP, GHRL
2nucleoplasmGO:0056548.0PPARG, PRKCD, CCND1, NR1H3, NR3C1, NR1H2
3cytoplasmGO:0057377.7GNAS, GNAI2, LIF, PRKCD, NR3C1, NR1H2
4cytosolGO:0058297.3PPARG, AIP, GNAS, GNAI2, PRKCD, CCND1
5nucleusGO:0056345.9CDKN2A, PPARG, AIP, GNAS, GNAI2, PRKCD

Biological processes related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1leukemia inhibitory factor signaling pathwayGO:04886110.3LIF, LIFR
2positive regulation of cholesterol transportGO:03237610.3NR1H2, NR1H3
3negative regulation of pinocytosisGO:04855010.3NR1H3, NR1H2
4negative regulation of lipid transportGO:03236910.3NR1H3, NR1H2
5regulation of cholesterol homeostasisGO:200018810.3NR1H3, NR1H2
6positive regulation of fatty acid biosynthetic processGO:04572310.2NR1H2, NR1H3
7positive regulation of triglyceride biosynthetic processGO:01086710.2NR1H2, NR1H3
8positive regulation of cAMP-mediated signalingGO:04395010.2GNAS, GIP
9positive regulation of lipoprotein lipase activityGO:05100610.2NR1H2, NR1H3
10response to lipidGO:03399310.1PPARG, GIP
11positive regulation of cholesterol effluxGO:01087510.1NR1H2, NR1H3
12positive regulation of cellular protein metabolic processGO:03227010.1NR1H2, NR1H3
13decidualizationGO:04669710.1GHRL, LIF
14triglyceride homeostasisGO:07032810.0NR1H3, GIP
15negative regulation of inflammatory responseGO:0507289.9NR1H3, GHRL, PRKCD
16negative regulation of proteolysisGO:0458619.9NR1H3, NR1H2
17negative regulation of interferon-gamma-mediated signaling pathwayGO:0603369.9NR1H2, NR1H3, PPARG
18negative regulation of cholesterol storageGO:0108879.9NR1H2, NR1H3, PPARG
19negative regulation of macrophage derived foam cell differentiationGO:0107459.9PPARG, NR1H3, NR1H2
20lipid homeostasisGO:0550889.8PPARG, NR1H3
21response to estrogenGO:0436279.7PPARG, CCND1, GHRL
22G-protein coupled receptor signaling pathwayGO:0071869.6AVPR1B, PPARG, GNAI2, GHRL
23transcription initiation from RNA polymerase II promoterGO:0063679.5PPARG, NR1H3, NR3C1, NR1H2
24female pregnancyGO:0075659.5GNAS, GIP, CRHBP
25protein stabilizationGO:0508219.5PRKCD, GAPDH, CDKN2A
26response to drugGO:0424939.5CCND1, GIP, GNAS, PPARG
27cellular senescenceGO:0903989.4CDKN2A, PRKCD
28hormone-mediated signaling pathwayGO:0097559.3GHRL, CRHBP
29gene expressionGO:0104679.0PPARG, PRKCD, NR1H3, NR3C1, NR1H2
30positive regulation of transcription from RNA polymerase II promoterGO:0459449.0PPARG, LIF, NR1H3, NR1H2, TBX19, CDKN2A
31signal transductionGO:0071658.3PPARG, AIP, GNAI2, GIP, PRKCD, CRHBP

Molecular functions related to Acth-Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.1GNAI2, GNAS
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5NR1H2, NR1H3, PPARG
3steroid hormone receptor activityGO:0037079.5NR1H2, NR1H3, PPARG
4retinoid X receptor bindingGO:0469659.4NR1H2, PPARG
5protein bindingGO:0055156.0PRKCD, GNAI2, GNAS, AIP, PPARG, CCND1

Products for genes affiliated with Acth-Secreting Pituitary Adenoma

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Sources for Acth-Secreting Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet