MCID: ACT093
MIFTS: 38

Actinic Cheilitis malady

Category: Rare diseases

Aliases & Classifications for Actinic Cheilitis

About this section

Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 48 68
 
Actinic Cheilosis 48

Classifications:



Summaries for Actinic Cheilitis

About this section
Wikipedia:71 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to oral squamous cell carcinoma and cheilitis. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Proteolysis Putative SUMO-1 pathway and HIF1Alpha Pathway. Affiliated tissues include t cells and salivary gland, and related mouse phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and craniofacial.

Related Diseases for Actinic Cheilitis

About this section

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1oral squamous cell carcinoma29.4MSH2, TP53
2cheilitis10.8
3squamous cell carcinoma10.3
4rommen mueller sybert syndrome10.2MDM2, TP53
5functionless pituitary adenoma10.2MDM2, TP53
6endometrial squamous cell carcinoma10.1MDM2, TP53
7coronary stenosis10.1MDM2, TP53
8brain stem angioblastoma10.1MDM2, TP53
9house allergic alveolitis10.1MDM2, TP53
10endodermal sinus tumor10.1MDM2, TP53
11mucopolysaccharidosis10.1TNF, TP53
12brain oligodendroglioma10.1MDM2, TP53
13intraorbital meningioma10.1MDM2, TP53
14childhood central nervous system primitive neuroectodermal neoplasm10.1MDM2, TP53
15vascular myelopathy10.1MDM2, TP53
16enchondromatosis dwarfism deafness10.1MDM2, TP53
17acinic cell breast carcinoma10.1TNF, TP53
18breast epithelioid hemangioma10.1CDKN1A, TP53
19inverted follicular keratosis10.1CDKN1A, TP53
20pityriasis rosea10.1TNF, TP53
21perineural angioma10.1CDKN1A, TP53
22interstitial lung disease10.1MDM2, TP53
23early myoclonic encephalopathy10.1MDM2, TP53
24mediastinum sarcoma10.1MDM2, TP53
25stickler syndrome, type i10.1MDM2, TP53
26pulmonary immaturity10.1MDM2, TP53
27gallbladder papillomatosis10.1CDKN1A, TP53
28urinary tract obstruction10.1CDKN1A, MDM2
29conjunctival concretion10.1TNF, TP53
30adhesions of uterus10.1CDKN1A, MDM2
31anterior foramen magnum meningioma10.1TNF, TP53
32fallopian tube adenocarcinoma10.1CDKN1A, TP53
33maxillary sinus cholesteatoma10.1CDKN1A, TP53
34gestational choriocarcinoma10.0MDM2, TP53
35pericholangitis10.0CDKN1A, TNF
36mediastinum angiosarcoma10.0MDM2, TP53
37familial hypopituitarism10.0MSH2, TP53
38childhood brain germinoma10.0MSH2, TP53
39ideomotor apraxia10.0MSH2, TP53
40lattice corneal dystrophy10.0CDKN1A, TP53
41adenosarcoma10.0MDM2, TP53
42spastic paraplegia 110.0MDM2, TNF, TP53
43larynx liposarcoma10.0MSH2, TP53
44congenital symblepharon9.9MSH2, TP53
45palmoplantar keratosis9.9MDM2, TP53
46cervical verrucous carcinoma9.9CDKN1A, MDM2, TP53
47extraocular retinoblastoma9.9CDKN1A, MDM2, TP53
48integumentary system benign neoplasm9.9CDKN1A, MDM2, TP53
49plague9.9CDKN1A, TNF, TP53
50post-surgical hypoinsulinemia9.9CDKN1A, MDM2, TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

About this section

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-38.9CDKN1A, MDM2, MSH2, TP53

MGI Mouse Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.2CDKN1A, MDM2, TNF, TP53
2MP:00053809.2CDKN1A, MDM2, TNF, TP53
3MP:00053719.2CDKN1A, MDM2, TNF, TP53
4MP:00053709.2CDKN1A, MDM2, TNF, TP53
5MP:00053699.1CDKN1A, MDM2, TNF, TP53
6MP:00053848.4CDKN1A, MDM2, MSH2, TNF, TP53
7MP:00053818.4CDKN1A, MDM2, MSH2, TNF, TP53
8MP:00053978.4CDKN1A, MDM2, MSH2, TNF, TP53
9MP:00053878.4CDKN1A, MDM2, MSH2, TNF, TP53
10MP:00030128.4CDKN1A, MDM2, TNF, TP53
11MP:00107718.4CDKN1A, MDM2, MSH2, TNF, TP53
12MP:00020068.3CDKN1A, MDM2, MSH2, TNF, TP53
13MP:00036318.2CDKN1A, MDM2, MSH2, TNF, TP53

Drugs & Therapeutics for Actinic Cheilitis

About this section

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidapprovedPhase 4, Phase 1165106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2
Imiquimodapproved, investigationalPhase 414099011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
ZINC19632912
Zartra
Zyclara
imiquimod
3Dermatologic AgentsPhase 4, Phase 15806
4Photosensitizing AgentsPhase 4, Phase 1492
5interferonsPhase 42175
6Interferon InducersPhase 4294
7Adjuvants, ImmunologicPhase 42554
8Methyl 5-aminolevulinatePhase 4, Phase 160

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisActive, not recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

About this section

Anatomical Context for Actinic Cheilitis

About this section

MalaCards organs/tissues related to Actinic Cheilitis:

36
T cells, Salivary gland

Publications for Actinic Cheilitis

About this section

Articles related to Actinic Cheilitis:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. (27778327)
2017
2
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. (27241280)
2016
3
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. (27867726)
2016
4
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. (27579741)
2016
5
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. (27759902)
2016
6
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. (27981067)
2016
7
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. (27420649)
2016
8
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. (27513668)
2016
9
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. (27029007)
2016
10
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. (27864997)
2016
11
Optical diagnosis of actinic cheilitis by infrared spectroscopy. (27491855)
2016
12
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. (27159259)
2016
13
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. (26842232)
2016
14
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. (26515234)
2015
15
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. (26677980)
2015
16
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. (26711374)
2015
17
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. (26264639)
2015
18
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
19
Photodynamic therapy for actinic cheilitis: a systematic review. (25627629)
2015
20
Clinicopathological profile and management of 161 cases of actinic cheilitis. (26375219)
2015
21
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
22
Commentary on photodynamic therapy of actinic cheilitis. (25654194)
2015
23
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. (25662549)
2015
24
Treatment of Actinic Cheilitis. (26418628)
2015
25
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. (26174644)
2015
26
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. (25241153)
2014
27
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. (25400009)
2014
28
Regulatory T cells in the actinic cheilitis. (25060152)
2014
29
Dermoscopic features of plasma cell cheilitis and actinic cheilitis. (24474043)
2014
30
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
31
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. (23971281)
2013
32
Erbium laser resurfacing for actinic cheilitis. (24196339)
2013
33
Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). (24001384)
2013
34
Topical photodynamic therapy may not be effective for actinic cheilitis despite repeated treatments. (24201136)
2013
35
Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis. (23887482)
2013
36
Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia. (24320079)
2013
37
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. (24520545)
2013
38
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. (21689160)
2012
39
Treatment of actinic cheilitis using a 1,927-nm thulium fractional laser. (22211447)
2012
40
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
41
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. (22714758)
2012
42
Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. (23230642)
2012
43
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. (22481658)
2012
44
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
45
Prevalence and factors associated to actinic cheilitis in beach workers. (22335283)
2012
46
Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma. (21442435)
2011
47
Actinic cheilitis among agricultural workers in Campinas, Brazil. (21485236)
2011
48
Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy. (20626536)
2011
49
The prevalence of actinic cheilitis in farmers in a semi-arid northeastern region of Brazil. (22126872)
2011
50
Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma. (21323960)
2011

Variations for Actinic Cheilitis

About this section

Expression for genes affiliated with Actinic Cheilitis

About this section
Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

About this section

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5MDM2, TP53
29.5MDM2, TP53
39.5MDM2, TP53
4
Show member pathways
9.5MDM2, TP53
59.5MDM2, TP53
69.5MDM2, TP53
79.5MDM2, TP53
8
Show member pathways
9.5MDM2, TP53
99.5TNF, TP53
109.4CDKN1A, TP53
11
Show member pathways
9.4CDKN1A, TP53
129.4CDKN1A, TP53
139.4CDKN1A, TP53
149.4CDKN1A, TP53
159.4CDKN1A, TP53
169.3CDKN1A, MDM2
17
Show member pathways
9.3CDKN1A, MDM2
189.3CDKN1A, TNF
20
Show member pathways
9.2MSH2, TP53
21
Show member pathways
9.2MSH2, TP53
228.9CDKN1A, MDM2, TP53
23
Show member pathways
8.9CDKN1A, MDM2, TP53
24
Show member pathways
8.9CDKN1A, MDM2, TP53
25
Show member pathways
8.9CDKN1A, MDM2, TP53
268.9CDKN1A, MDM2, TP53
278.9CDKN1A, MDM2, TP53
28
Show member pathways
8.9CDKN1A, MDM2, TP53
29
Show member pathways
8.9CDKN1A, MDM2, TP53
30
Show member pathways
8.9CDKN1A, MDM2, TP53
31
Show member pathways
8.9CDKN1A, MDM2, TP53
328.9CDKN1A, MDM2, TP53
33
Show member pathways
8.9CDKN1A, MDM2, TP53
348.9CDKN1A, MDM2, TP53
358.9CDKN1A, MDM2, TP53
368.9CDKN1A, MDM2, TP53
378.9CDKN1A, MDM2, TP53
388.9CDKN1A, MDM2, TP53
39
Show member pathways
8.9CDKN1A, MDM2, TP53
40
Show member pathways
8.9CDKN1A, MDM2, TP53
418.9CDKN1A, MDM2, TP53
428.9CDKN1A, MDM2, TP53
43
Show member pathways
8.9CDKN1A, MDM2, TP53
44
Show member pathways
8.9CDKN1A, MDM2, TP53
458.9CDKN1A, MDM2, TP53
468.9CDKN1A, MDM2, TP53
47
Show member pathways
8.9CDKN1A, MDM2, TP53
488.9CDKN1A, TNF, TP53
498.9CDKN1A, TNF, TP53
508.9CDKN1A, TNF, TP53

GO Terms for genes affiliated with Actinic Cheilitis

About this section

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5CDKN1A, MDM2, TP53
2protein complexGO:00432348.9CDKN1A, MDM2, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1cellular response to actinomycin DGO:007271710.3MDM2, TP53
2cellular response to organic cyclic compoundGO:007140710.2MDM2, TNF
3cellular response to ionizing radiationGO:007147910.1CDKN1A, TP53
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1CDKN1A, TP53
5intrinsic apoptotic signaling pathwayGO:009719310.1CDKN1A, TP53
6positive regulation of protein export from nucleusGO:004682710.1MDM2, TP53
7positive regulation of vascular smooth muscle cell proliferationGO:190470710.0MDM2, TNF
8response to antibioticGO:004667710.0MDM2, TP53
9positive regulation of reactive oxygen species metabolic processGO:200037910.0CDKN1A, TP53
10positive regulation of programmed cell deathGO:004306810.0CDKN1A, TNF
11Ras protein signal transductionGO:000726510.0CDKN1A, TP53
12replicative senescenceGO:00903999.9CDKN1A, TP53
13determination of adult lifespanGO:00083409.9MSH2, TP53
14positive regulation of protein kinase activityGO:00458609.9CDKN1A, TNF
15intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.9MSH2, TNF
16response to glucocorticoidGO:00513849.7CDKN1A, TNF
17negative regulation of transcription, DNA-templatedGO:00458929.7MDM2, TNF, TP53
18cellular response to gamma radiationGO:00714809.6CDKN1A, MDM2, TP53
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.6CDKN1A, MDM2, TP53
20positive regulation of gene expressionGO:00106289.6MDM2, TNF, TP53
21negative regulation of apoptotic processGO:00430669.6CDKN1A, MDM2, TP53
22negative regulation of gene expressionGO:00106299.5CDKN1A, MDM2, TNF
23signal transduction by p53 class mediatorGO:00723319.4CDKN1A, TP53
24cell cycle arrestGO:00070509.3CDKN1A, MSH2, TP53
25cellular response to DNA damage stimulusGO:00069749.3CDKN1A, MSH2, TP53
26intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.3CDKN1A, MSH2, TP53
27response to X-rayGO:00101658.7CDKN1A, MSH2, TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1disordered domain specific bindingGO:009771810.2MDM2, TP53
2p53 bindingGO:000203910.2MDM2, TP53
3damaged DNA bindingGO:00036849.9MSH2, TP53
4enzyme bindingGO:00198999.4MDM2, MSH2, TP53
5protein kinase bindingGO:00199019.2CDKN1A, MSH2, TP53
6ubiquitin protein ligase bindingGO:00316258.9CDKN1A, MDM2, TP53

Sources for Actinic Cheilitis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet