MCID: ACT093
MIFTS: 37

Actinic Cheilitis malady

Summaries for Actinic Cheilitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Actinic cheilitis (also known as \"actinic cheilosis\", \"sailor\'s lip\"), is a form of cheilitis which... more...

MalaCards: Actinic Cheilitis, also known as actinic cheilosis, is related to squamous cell carcinoma and cheilitis. An important gene associated with Actinic Cheilitis is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are TGF-Beta Pathway and Doxorubicin Pathway, Pharmacokinetics. The compounds estrogen and pdtc have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are adipose tissue and renal/urinary system.

Aliases & Classifications for Actinic Cheilitis

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

actinic cheilitis 42 60
actinic cheilosis 42


Related Diseases for Actinic Cheilitis

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17GeneCards, 18GeneDecks
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Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.9STAT3, ITGA3, BAX, MKI67, CDKN1A, FGFR3
2cheilitis11.1
3acne10.3
4lip cancer10.3
5lower lip cancer10.1
6oculocutaneous albinism10.1
7albinism10.1
8systemic lupus erythematosus10.0PDCD1
9dilated cardiomyopathy10.0CHKB
10testicular cancer10.0ERCC1
11deficiency anemia10.0CHKB
12letterer-siwe disease10.0CD1A
13polymyositis10.0CHKB
14cervical intraepithelial neoplasia10.0MKI67
15meningioma10.0MKI67
16leiomyoma10.0MKI67
17dermatomyositis10.0CHKB
18histiocytosis10.0CD1A
19bronchiolitis10.0APEX1
20leukoplakia10.0MKI67
21acute leukemia10.0MSH2
22smooth muscle tumor10.0MKI67
23bladder transitional cell papilloma10.0FGFR3
24cholesteatoma10.0MMP9
25pulmonary disease, chronic obstructive10.0MMP9
26root resorption10.0CTNNBIP1
27skin disease10.0MMP9
28pituitary adenoma10.0MKI67
29periodontitis10.0MMP9
30pulmonary fibrosis10.0MMP9
31sjogren's syndrome10.0BAX
32cystic fibrosis10.0APEX1
33hepatitis b10.0STAT3
34myositis10.0CHKB
35gallbladder cancer10.0TP53
36lupus nephritis10.0CD274, PDCD1
37ductal carcinoma in situ10.0TP53
38dermatofibrosarcoma10.0MDM2
39inflammatory bowel disease10.0STAT3
40meningitis10.0MMP9
41neuroblastoma10.0TP53
42endometriosis10.0PTGS2
43myocarditis10.0CHKB
44proteinuria10.0CD274
45anaplastic large cell lymphoma10.0STAT3
46neutropenia10.0STAT3
47sebaceous adenoma10.0MSH2
48amyotrophic lateral sclerosis10.0APEX1, CHKB
49actinic keratosis10.0TP53
50galactosemia10.0TNF

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Clinical Features for Actinic Cheilitis

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Drugs & Therapeutics for Actinic Cheilitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Actinic Cheilitis

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Anatomical Context for Actinic Cheilitis

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32MalaCards
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MalaCards organs/tissues related to Actinic Cheilitis:

32
Skin

Animal Models for Actinic Cheilitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Actinic Cheilitis:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2ERCC1
2MP:000536710.1FGFR3, ITGA3, PDCD1
3MP:000539110.0FGFR3, ITGA3, PDCD1
4MP:00053809.7CTNNBIP1, SERPINB5, ITGA3
5MP:00053769.3CHKB, CD274, FGFR3, APEX1, ITGA3
6MP:00020069.1MSH2, TNF, MDM2, CDKN1A, FGFR3, MMP9
7MP:00053909.0CDKN1A, CHKB, FGFR3, BAX, STAT3, CTNNBIP1
8MP:00107719.0CDKN1A, MDM2, MMP9, PTGS2, TP53, ERCC1
9MP:00053698.9PDCD1, CDKN1A, BAX, CHKB, MDM2, APEX1
10MP:00053798.9TNF, TP53, CDKN1A, BAX, STAT3, APEX1
11MP:00036318.9CDKN1A, BAX, CHKB, ITGA3, STAT3, CTNNBIP1
12MP:00053828.7FGFR3, CDKN1A, MDM2, TNF, CTNNBIP1, TP53
13MP:00030128.4TP53, PTGS2, FGFR3, CDKN1A, CD274, MDM2
14MP:00053898.4ERCC1, PTGS2, MMP9, APEX1, STAT3, FGFR3
15MP:00053888.4FGFR3, PTGS2, TP53, CDKN1A, BAX, CTNNBIP1
16MP:00053858.3STAT3, PTGS2, CDKN1A, ITGA3, TP53, PDCD1
17MP:00053708.3APEX1, PDCD1, MDM2, CDKN1A, PTGS2, TP53
18MP:00053817.5ITGA3, MDM2, CTNNBIP1, STAT3, CDKN1A, FGFR3
19MP:00053787.3APEX1, MDM2, STAT3, ITGA3, BAX, FGFR3
20MP:00053977.3TNF, MDM2, STAT3, BAX, PDCD1, CDKN1A
21MP:00053867.1TNF, MDM2, STAT3, ITGA3, PTGS2, MMP9
22MP:00053876.8STAT3, TP53, TNF, APEX1, ERCC1, MSH2
23MP:00053846.5BAX, STAT3, CD274, MDM2, CDKN1A, FGFR3
24MP:00107686.2PTGS2, MMP9, FGFR3, CDKN1A, CD274, BAX

Publications for Actinic Cheilitis

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Genetic Variations for Actinic Cheilitis

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Expression for genes affiliated with Actinic Cheilitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

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Sources:
51QIAGEN, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 4Cell Signaling Technology, 52R&D Systems, 53Reactome
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Pathways related to Actinic Cheilitis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1ITGA3
2
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9.9TP53, MSH2
3
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9.8SERPINB5, BAX, MDM2
4
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9.8MDM2, BAX, FGFR3
59.8APEX1, STAT3, MSH2
69.8TP53, MDM2, APEX1
79.7MDM2, CDKN1A, TP53
89.7TP53, CDKN1A, MDM2
99.7TP53, CDKN1A, BAX
109.6CDKN1A, MMP9, PTGS2
119.6TNF, BAX, CDKN1A
129.6TNF, STAT3, BAX
13
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9.6TNF, BAX, TP53
149.5SERPINB5, PTGS2, MMP9, FGFR3
159.5BAX, CDKN1A, SERPINB5, TP53
16
Transcription P53 signaling pathway
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9.5TP53, CDKN1A, MDM2, APEX1
17
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9.5TP53, FGFR3, CDKN1A, MDM2
189.5MDM2, CDKN1A, FGFR3, TP53
199.5MDM2, BAX, MSH2, TP53
209.4MDM2, CDKN1A, MMP9, TP53
21
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9.4MDM2, BAX, CDKN1A, TP53
22
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9.4TP53, CDKN1A, BAX, MDM2
239.4MDM2, BAX, CDKN1A, TP53
249.4MDM2, BAX, CDKN1A, TP53
25
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9.4MDM2, STAT3, CDKN1A, TP53
26
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9.4MDM2, STAT3, CDKN1A, TP53
279.4TP53, CDKN1A, STAT3, MDM2
289.4TP53, MMP9, APEX1, TNF
29
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9.4APEX1, MDM2, CDKN1A, MSH2, ERCC1
30
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9.3TNF, STAT3, BAX, CDKN1A
31
Apoptosis and survival Apoptotic TNF-family pathways
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9.3TNF, BAX, CDKN1A, TP53
32
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9.3STAT3, ITGA3, FGFR3, TP53
339.3TP53, CDKN1A, STAT3, TNF
34
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9.3MDM2, STAT3, CDKN1A, FGFR3, MMP9
35
Development PDGF signaling via STATs and NF-kB
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9.2TNF, STAT3, ITGA3, CDKN1A
36
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9.2MDM2, STAT3, BAX, MSH2, TP53
379.2TP53, CDKN1A, BAX, STAT3, MDM2
38
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9.1BAX, CDKN1A, FGFR3, PTGS2, TP53
399.1MDM2, ITGA3, CDKN1A, FGFR3, TP53
409.0MDM2, BAX, CDKN1A, MSH2, SERPINB5, TP53
41
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8.9MDM2, STAT3, BAX, CDKN1A, MSH2, TP53
42
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8.8APEX1, MDM2, MKI67, CDKN1A, MSH2, ERCC1
438.8TNF, MDM2, STAT3, CDKN1A, MMP9, TP53
44
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8.8TNF, STAT3, BAX, CDKN1A, MMP9, TP53
458.8TNF, MDM2, BAX, CDKN1A, PTGS2, TP53
46
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8.5TNF, MDM2, ITGA3, BAX, FGFR3, MMP9
478.5MDM2, STAT3, CDKN1A, FGFR3, MMP9, PTGS2
48
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8.2TNF, MDM2, STAT3, ITGA3, BAX, CDKN1A
49
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7.9TNF, MDM2, STAT3, ITGA3, BAX, CDKN1A
507.8TP53, MDM2, STAT3, ITGA3, BAX, CDKN1A

Compounds for genes affiliated with Actinic Cheilitis

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Actinic Cheilitis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHKB
2pdtc4410.5SERPINB5, MMP9
3h2o24410.1CDKN1A, APEX1, CHKB
4etoposide44 49 59 1113.0MDM2, BAX, ERCC1
510-hydroxycamptothecin449.8CDKN1A, TP53, BAX, MDM2
6tamoxifen44 49 28 1112.7MKI67, CDKN1A, SERPINB5, CHKB
7noxa449.7BAX, MDM2, TP53, CDKN1A
8vincristine44 49 1111.7BAX, ERCC1, MKI67
9dexamethasone44 49 28 1112.6PTGS2, MDM2, MMP9, STAT3
10flavopiridol44 1110.5TP53, MDM2, CDKN1A, STAT3, BAX
11bortezomib44 1110.5CDKN1A, TP53, FGFR3, BAX, STAT3
12triptolide449.5TNF, TP53, BAX, PTGS2
13ns 39844 5910.4PTGS2, MMP9, CDKN1A, TNF
14indole-3-carbinol449.4TP53, CDKN1A, STAT3, BAX
15gefitinib44 49 1111.4STAT3, MDM2, PTGS2, CDKN1A, MMP9
16melphalan44 1110.4TNF, TP53, MDM2, CHKB, FGFR3, ERCC1
17sulindac44 1110.4BAX, CDKN1A, PTGS2, TP53, STAT3
18parthenolide44 210.4STAT3, PTGS2, TNF, TP53, MMP9
19gemcitabine44 49 1111.3APEX1, BAX, CDKN1A, PTGS2, ERCC1, TP53
20docetaxel44 49 59 1112.3MDM2, STAT3, ERCC1, TP53, BAX, CDKN1A
21paclitaxel44 49 1111.3BAX, STAT3, MDM2, TP53, ERCC1, CDKN1A
22arsenite44 2410.2MDM2, BAX, MMP9, CDKN1A, STAT3, TP53
23camptothecin44 59 1111.2APEX1, MDM2, BAX, CDKN1A, TP53
24ciglitazone44 2810.2STAT3, BAX, CDKN1A, MMP9, PTGS2, TNF
25celecoxib44 59 28 49 11 2414.2MMP9, CDKN1A, MKI67, BAX, PTGS2
26irinotecan44 49 1111.2MDM2, BAX, MKI67, CDKN1A, ERCC1, TP53
27mg 13244 5910.2TNF, STAT3, CDKN1A, TP53, BAX, MDM2
28sulforaphane449.1PTGS2, CDKN1A, APEX1, BAX
29dutp449.1MKI67, BAX, MDM2, TP53
30lactacystin449.0MMP9, ERCC1, CDKN1A, STAT3, MDM2, TNF
31troglitazone44 28 59 1112.0CDKN1A, BAX, PTGS2, MMP9, TNF
32methotrexate44 49 1111.0MMP9, TNF, CHKB, MKI67, MDM2, ERCC1
33adpribose449.0APEX1, MDM2, BAX, TNF, CDKN1A, STAT3
34sp 60012544 5910.0STAT3, MMP9, CDKN1A, BAX, MDM2, TNF
35thymidylate448.9TP53, ERCC1, MSH2, CDKN1A, MKI67, BAX
36sb 20358044 599.8MMP9, STAT3, PTGS2, TP53, BAX, TNF
37genistein44 28 59 2 11 2413.8BAX, CDKN1A, STAT3, MDM2, TNF, PTGS2
38pd 98,059448.8BAX, CDKN1A, MMP9, PTGS2, ERCC1, MDM2
39curcumin448.7BAX, CDKN1A, TP53, PTGS2, MMP9, STAT3
40ly294002448.6BAX, TP53, PTGS2, STAT3, MMP9, MDM2
41actinomycin d448.6PTGS2, MMP9, CDKN1A, TP53, TNF, STAT3
425fluorouracil448.6ERCC1, MSH2, CDKN1A, MDM2, MKI67, BAX
43thymidine44 249.5ERCC1, CDKN1A, CHKB, TP53, MKI67, STAT3
44n acetylcysteine448.5BAX, CDKN1A, MMP9, TP53, STAT3, APEX1
45serine448.5TNF, APEX1, STAT3, ITGA3, MMP9, MKI67
46doxorubicin44 49 1110.4MSH2, MKI67, ERCC1, TP53, FGFR3, CDKN1A
47nitric oxide44 11 2410.2MKI67, MDM2, SERPINB5, PTGS2, CD274, CHKB
48cisplatin44 49 59 1111.0MDM2, STAT3, BAX, MKI67, CDKN1A, MSH2
49paraffin447.8MKI67, MDM2, STAT3, CHKB, BAX, CDKN1A
50vegf447.4TP53, TNF, SERPINB5, ERCC1, PTGS2, MMP9

GO Terms for genes affiliated with Actinic Cheilitis

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16Gene Ontology
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Cellular components related to Actinic Cheilitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.0TP53, ERCC1, CDKN1A, STAT3, MDM2, APEX1

Biological processes related to Actinic Cheilitis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1germ cell developmentGO:00728110.1ERCC1, MSH2, BAX
2positive regulation of programmed cell deathGO:04306810.1TNF, CDKN1A
3positive regulation of fever generationGO:03162210.1TNF, PTGS2
4response to X-rayGO:01016510.1MSH2, ERCC1, TP53
5transformed cell apoptotic processGO:00692710.1TNF, BAX
6positive regulation of protein oligomerizationGO:03246110.0TP53, BAX
7double-strand break repairGO:00630210.0TP53, ERCC1, MSH2
8determination of adult lifespanGO:0083409.9TP53, MSH2
9mitotic cell cycle arrestGO:0718509.9TP53, CDKN1A
10response to salt stressGO:0096519.9TP53, BAX, TNF
11intrinsic apoptotic signaling pathwayGO:0971939.9TP53, CDKN1A, BAX
12cellular response to UVGO:0346449.9BAX, PTGS2, TP53
13positive regulation of neuron apoptotic processGO:0435259.8TP53, BAX, TNF
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.8TP53, CDKN1A, MDM2
15cellular response to hypoxiaGO:0714569.5MDM2, PTGS2, TP53
16negative regulation of apoptotic processGO:0430669.4MDM2, CDKN1A, FGFR3, ERCC1, TP53
17neurotrophin TRK receptor signaling pathwayGO:0480119.2FGFR3, CDKN1A, STAT3, MDM2
18response to drugGO:0424939.2TNF, APEX1, MDM2, STAT3, CDKN1A, PTGS2
19positive regulation of apoptotic processGO:0430659.1TP53, PTGS2, MMP9, FGFR3, BAX, TNF
20negative regulation of transcription from RNA polymerase II promoterGO:0001229.0TP53, FGFR3, STAT3, MDM2, CTNNBIP1, TNF

Molecular functions related to Actinic Cheilitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.7APEX1, ERCC1, TP53
2enzyme bindingGO:0198999.4TP53, PTGS2, MSH2, MDM2
3identical protein bindingGO:0428028.8TNF, MDM2, BAX, MMP9, TP53
4protein bindingGO:0055155.4TP53, PDCD1, TNF, APEX1, CTNNBIP1, MDM2

Products for genes affiliated with Actinic Cheilitis

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  • Antibodies
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Sources for Actinic Cheilitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet