MCID: ACT093
MIFTS: 38

Actinic Cheilitis malady

Categories: Rare diseases

Aliases & Classifications for Actinic Cheilitis

Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 50 69
Actinic Cheilosis 50

Classifications:



Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to oral squamous cell carcinoma and cheilitis. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and Regulation of TP53 Activity. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 71 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 oral squamous cell carcinoma 29.4 MSH2 TP53
2 cheilitis 10.8
3 squamous cell carcinoma 10.3
4 rommen mueller sybert syndrome 10.2 MDM2 TP53
5 functionless pituitary adenoma 10.2 MDM2 TP53
6 endometrial squamous cell carcinoma 10.1 MDM2 TP53
7 coronary stenosis 10.1 MDM2 TP53
8 brain stem angioblastoma 10.1 MDM2 TP53
9 house allergic alveolitis 10.1 MDM2 TP53
10 endodermal sinus tumor 10.1 MDM2 TP53
11 mucopolysaccharidosis 10.1 TNF TP53
12 brain oligodendroglioma 10.1 MDM2 TP53
13 intraorbital meningioma 10.1 MDM2 TP53
14 childhood central nervous system primitive neuroectodermal neoplasm 10.1 MDM2 TP53
15 vascular myelopathy 10.1 MDM2 TP53
16 enchondromatosis dwarfism deafness 10.1 MDM2 TP53
17 acinic cell breast carcinoma 10.1 TNF TP53
18 breast epithelioid hemangioma 10.1 CDKN1A TP53
19 inverted follicular keratosis 10.1 CDKN1A TP53
20 pityriasis rosea 10.1 TNF TP53
21 perineural angioma 10.1 CDKN1A TP53
22 interstitial lung disease 10.1 MDM2 TP53
23 early myoclonic encephalopathy 10.1 MDM2 TP53
24 mediastinum sarcoma 10.1 MDM2 TP53
25 stickler syndrome, type i 10.1 MDM2 TP53
26 pulmonary immaturity 10.1 MDM2 TP53
27 gallbladder papillomatosis 10.1 CDKN1A TP53
28 urinary tract obstruction 10.1 CDKN1A MDM2
29 conjunctival concretion 10.1 TNF TP53
30 adhesions of uterus 10.1 CDKN1A MDM2
31 anterior foramen magnum meningioma 10.1 TNF TP53
32 fallopian tube adenocarcinoma 10.1 CDKN1A TP53
33 maxillary sinus cholesteatoma 10.1 CDKN1A TP53
34 gestational choriocarcinoma 10.0 MDM2 TP53
35 pericholangitis 10.0 CDKN1A TNF
36 mediastinum angiosarcoma 10.0 MDM2 TP53
37 familial hypopituitarism 10.0 MSH2 TP53
38 childhood brain germinoma 10.0 MSH2 TP53
39 ideomotor apraxia 10.0 MSH2 TP53
40 lattice corneal dystrophy 10.0 CDKN1A TP53
41 adenosarcoma 10.0 MDM2 TP53
42 spastic paraplegia 1 10.0 MDM2 TNF TP53
43 larynx liposarcoma 10.0 MSH2 TP53
44 congenital symblepharon 9.9 MSH2 TP53
45 palmoplantar keratosis 9.9 MDM2 TP53
46 cervical verrucous carcinoma 9.9 CDKN1A MDM2 TP53
47 extraocular retinoblastoma 9.9 CDKN1A MDM2 TP53
48 integumentary system benign neoplasm 9.9 CDKN1A MDM2 TP53
49 plague 9.9 CDKN1A TNF TP53
50 post-surgical hypoinsulinemia 9.9 CDKN1A MDM2 TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 CDKN1A MDM2 MSH2 TNF TP53
2 digestive/alimentary MP:0005381 9.89 CDKN1A MDM2 MSH2 TNF TP53
3 hematopoietic system MP:0005397 9.85 CDKN1A MDM2 MSH2 TNF TP53
4 immune system MP:0005387 9.83 CDKN1A MDM2 MSH2 TNF TP53
5 craniofacial MP:0005382 9.81 CDKN1A MDM2 TNF TP53
6 integument MP:0010771 9.8 MSH2 TNF TP53 CDKN1A MDM2
7 embryo MP:0005380 9.78 MDM2 TNF TP53 CDKN1A
8 limbs/digits/tail MP:0005371 9.67 CDKN1A MDM2 TNF TP53
9 liver/biliary system MP:0005370 9.62 CDKN1A MDM2 TNF TP53
10 muscle MP:0005369 9.56 CDKN1A MDM2 TNF TP53
11 neoplasm MP:0002006 9.55 CDKN1A MDM2 MSH2 TNF TP53
12 nervous system MP:0003631 9.35 CDKN1A MDM2 MSH2 TNF TP53
13 no phenotypic analysis MP:0003012 8.92 TP53 CDKN1A MDM2 TNF

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 interferons Phase 4
4 Adjuvants, Immunologic Phase 4
5 Dermatologic Agents Phase 4,Phase 1
6 Photosensitizing Agents Phase 4,Phase 1
7 Interferon Inducers Phase 4
8 Methyl 5-aminolevulinate Phase 4,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4
4 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

39
T Cells, Salivary Gland

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 135)
id Title Authors Year
1
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
2
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
3
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
4
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
5
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
6
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
7
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
8
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
9
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
10
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
11
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
12
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
13
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
14
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
15
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015
16
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2015
17
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2015
18
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
19
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015
20
Clinicopathological profile and management of 161 cases of actinic cheilitis. ( 26375219 )
2015
21
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. ( 26179312 )
2015
22
Commentary on photodynamic therapy of actinic cheilitis. ( 25654194 )
2015
23
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. ( 25662549 )
2015
24
Treatment of Actinic Cheilitis. ( 26418628 )
2015
25
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. ( 26174644 )
2015
26
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. ( 25241153 )
2014
27
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. ( 25400009 )
2014
28
Regulatory T cells in the actinic cheilitis. ( 25060152 )
2014
29
Dermoscopic features of plasma cell cheilitis and actinic cheilitis. ( 24474043 )
2014
30
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. ( 25039599 )
2014
31
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. ( 23971281 )
2013
32
Erbium laser resurfacing for actinic cheilitis. ( 24196339 )
2013
33
Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). ( 24001384 )
2013
34
Topical photodynamic therapy may not be effective for actinic cheilitis despite repeated treatments. ( 24201136 )
2013
35
Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis. ( 23887482 )
2013
36
Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia. ( 24320079 )
2013
37
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. ( 24520545 )
2013
38
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. ( 21689160 )
2012
39
Treatment of actinic cheilitis using a 1,927-nm thulium fractional laser. ( 22211447 )
2012
40
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. ( 22370573 )
2012
41
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. ( 22714758 )
2012
42
Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. ( 23230642 )
2012
43
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. ( 22481658 )
2012
44
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. ( 22917688 )
2012
45
Prevalence and factors associated to actinic cheilitis in beach workers. ( 22335283 )
2012
46
Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma. ( 21442435 )
2011
47
Actinic cheilitis among agricultural workers in Campinas, Brazil. ( 21485236 )
2011
48
Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy. ( 20626536 )
2011
49
The prevalence of actinic cheilitis in farmers in a semi-arid northeastern region of Brazil. ( 22126872 )
2011
50
Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma. ( 21323960 )
2011

Variations for Actinic Cheilitis

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CDKN1A MDM2 TNF TP53
2
Show member pathways
12.77 CDKN1A MDM2 MSH2 TP53
3
Show member pathways
12.61 CDKN1A MDM2 TNF TP53
4
Show member pathways
12.55 CDKN1A MDM2 TP53
5
Show member pathways
12.46 CDKN1A MDM2 TP53
6 12.45 CDKN1A MDM2 MSH2 TP53
7
Show member pathways
12.43 CDKN1A MDM2 MSH2 TP53
8 12.42 CDKN1A MDM2 TP53
9
Show member pathways
12.39 CDKN1A MDM2 TP53
10 12.35 CDKN1A MDM2 TP53
11
Show member pathways
12.34 CDKN1A MSH2 TNF TP53
12 12.27 CDKN1A TNF TP53
13 12.26 CDKN1A MDM2 MSH2 TP53
14
Show member pathways
12.24 CDKN1A MDM2 TP53
15
Show member pathways
12.22 CDKN1A MDM2 TP53
16 12.21 CDKN1A MDM2 TP53
17
Show member pathways
12.16 CDKN1A MDM2 TP53
18 12.15 CDKN1A MDM2 TP53
19 12.15 CDKN1A MDM2 TP53
20
Show member pathways
12.11 CDKN1A MDM2 TP53
21 12.09 CDKN1A MDM2 TP53
22
Show member pathways
12.09 CDKN1A MDM2 MSH2 TP53
23
Show member pathways
12.04 CDKN1A MDM2 TP53
24 12.01 MDM2 MSH2 TP53
25 12.01 CDKN1A MDM2 TNF TP53
26 11.96 CDKN1A MDM2 TP53
27
Show member pathways
11.95 CDKN1A MDM2 TP53
28 11.92 CDKN1A TNF TP53
29 11.89 CDKN1A MSH2 TNF TP53
30 11.85 CDKN1A MDM2 TP53
31 11.84 CDKN1A TNF TP53
32 11.81 CDKN1A MDM2 TP53
33 11.79 CDKN1A MDM2 TP53
34 11.7 CDKN1A MDM2 TP53
35 11.69 CDKN1A MDM2 MSH2 TP53
36
Show member pathways
11.68 CDKN1A MDM2 TP53
37
Show member pathways
11.67 CDKN1A MDM2
38
Show member pathways
11.65 MSH2 TP53
39 11.65 CDKN1A MDM2 TP53
40
Show member pathways
11.6 MDM2 TP53
41 11.58 CDKN1A MDM2 TP53
42 11.58 CDKN1A MDM2 MSH2 TP53
43 11.56 CDKN1A MDM2 TP53
44 11.5 MDM2 TP53
45 11.48 CDKN1A MDM2
47 11.46 MDM2 TP53
48 11.45 MDM2 TP53
49
Show member pathways
11.45 MDM2 TP53
50 11.43 CDKN1A TP53

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.13 CDKN1A MDM2 TP53
2 nuclear body GO:0016604 8.8 CDKN1A MDM2 TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.81 MDM2 TNF TP53
2 negative regulation of apoptotic process GO:0043066 9.8 CDKN1A MDM2 TP53
3 cellular response to DNA damage stimulus GO:0006974 9.78 CDKN1A MSH2 TP53
4 positive regulation of gene expression GO:0010628 9.76 MDM2 TNF TP53
5 negative regulation of gene expression GO:0010629 9.67 CDKN1A MDM2 TNF
6 cellular response to organic cyclic compound GO:0071407 9.63 MDM2 TNF
7 response to glucocorticoid GO:0051384 9.62 CDKN1A TNF
8 Ras protein signal transduction GO:0007265 9.61 CDKN1A TP53
9 cell cycle arrest GO:0007050 9.61 CDKN1A MSH2 TP53
10 positive regulation of protein kinase activity GO:0045860 9.6 CDKN1A TNF
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.59 MSH2 TNF
12 response to antibiotic GO:0046677 9.58 MDM2 TP53
13 positive regulation of reactive oxygen species metabolic process GO:2000379 9.57 CDKN1A TP53
14 cellular response to ionizing radiation GO:0071479 9.56 CDKN1A TP53
15 intrinsic apoptotic signaling pathway GO:0097193 9.55 CDKN1A TP53
16 positive regulation of protein export from nucleus GO:0046827 9.54 MDM2 TP53
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 MDM2 TNF
18 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.51 CDKN1A TP53
19 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 CDKN1A MDM2 TP53
20 determination of adult lifespan GO:0008340 9.48 MSH2 TP53
21 replicative senescence GO:0090399 9.46 CDKN1A TP53
22 positive regulation of programmed cell death GO:0043068 9.4 CDKN1A TNF
23 signal transduction by p53 class mediator GO:0072331 9.37 CDKN1A TP53
24 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
25 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
26 cellular response to gamma radiation GO:0071480 9.13 CDKN1A MDM2 TP53
27 response to X-ray GO:0010165 8.8 CDKN1A MSH2 TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.43 CDKN1A MSH2 TP53
2 p53 binding GO:0002039 9.37 MDM2 TP53
3 enzyme binding GO:0019899 9.33 MDM2 MSH2 TP53
4 damaged DNA binding GO:0003684 9.32 MSH2 TP53
5 ubiquitin protein ligase binding GO:0031625 9.13 CDKN1A MDM2 TP53
6 disordered domain specific binding GO:0097718 8.62 MDM2 TP53

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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