Aliases & Classifications for Actinic Cheilitis

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Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 45 65
 
Actinic Cheilosis 45


Classifications:



Summaries for Actinic Cheilitis

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Wikipedia:68 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to skin tag and lip cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Aurora A signaling and Proteolysis Putative SUMO-1 pathway. Affiliated tissues include t cells and salivary gland, and related mouse phenotypes are skeleton and limbs/digits/tail.

Related Diseases for Actinic Cheilitis

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Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1skin tag30.7MSH2, TP53
2lip cancer30.4TNF, TP53
3cheilitis11.2
4mouth disease10.4
5acne10.3
6phototoxic dermatitis10.3
7oculocutaneous albinism10.2
8median arcuate ligament syndrome10.2
9coats disease10.2
10oral squamous cell carcinoma10.2
11blood coagulation disease10.2
12corneal disease10.2
13albinism10.2
14factor v leiden thrombophilia10.2
15cheilitis glandularis10.2
16chiari malformation type 210.2
17leukoplakia10.2
18ring chromosome 810.2MDM2, TP53
19gastric liposarcoma10.2MDM2, TP53
20familial congenital fourth cranial nerve palsy10.2MSH2, TP53
21primary eye hypotony10.2MDM2, TP53
22angioedema10.2MDM2, TP53
23laryngeal mucoepidermoid carcinoma10.2MDM2, TP53
24acantholytic variant squamous cell breast carcinoma10.1MDM2, TP53
25bronchogenic lung adenocarcinoma10.1MDM2, TP53
26autosomal dominant charcot-marie-tooth disease type 2a210.1MDM2, TP53
27biliary tract intraductal papillary mucinous neoplasm10.1MDM2, TP53
28nemaline myopathy10.1MDM2, TP53
29embryonal tumor with multilayered rosettes10.1MDM2, TP53
30autosomal dominant charcot-marie-tooth disease type 2f10.1MDM2, TP53
31adult leptomeningeal melanoma10.1MSH2, TP53
32anterior spinal artery syndrome10.1MDM2, TP53
33malignant ovarian surface epithelial-stromal neoplasm10.1MDM2, TP53
34intestinal disease10.1MSH2, TP53
35gliosarcoma10.1MDM2, TP53
36keratoconjunctivitis10.1MSH2, TP53
37myxoid liposarcoma10.1MDM2, TP53
38juvenile astrocytoma10.1MDM2, TP53
39retinal degeneration10.1MDM2, TP53
40spondyloepimetaphyseal dysplasia, sponastrime type10.1MSH2, TP53
41necrosis of ear ossicle10.1MDM2, TP53
42histiocytosis10.1MDM2, TP53
43hypercalcemia10.1TNF, TP53
44common variable immunodeficiency10.1MSH2, TP53
45connective tissue disease10.1MDM2, TP53
46microphthalmia, syndromic 410.1MSH2, TP53
47ciliopathy10.1TNF, TP53
48corpus callosum oligodendroglioma10.1MDM2, TP53
49rectum adenocarcinoma10.1MSH2, TP53
50leishmaniasis10.0MDM2, TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms for Actinic Cheilitis

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Drugs & Therapeutics for Actinic Cheilitis

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Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Imiquimodapproved, investigationalPhase 412699011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
2
Aminolevulinic acidapprovedPhase 4, Phase 1128106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulan Kerastick
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
3Methyl 5-aminolevulinatePhase 4, Phase 147

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

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Anatomical Context for Actinic Cheilitis

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MalaCards organs/tissues related to Actinic Cheilitis:

33
T cells, Salivary gland

Animal Models for Actinic Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Actinic Cheilitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.4MDM2, MMP9, TNF, TP53
2MP:00053718.4MDM2, MMP9, TNF, TP53
3MP:00053698.3MDM2, MMP9, TNF, TP53
4MP:00053817.8MDM2, MMP9, MSH2, TNF, TP53
5MP:00053847.8MDM2, MMP9, MSH2, TNF, TP53
6MP:00107717.6MDM2, MMP9, MSH2, TNF, TP53
7MP:00020067.5MDM2, MMP9, MSH2, TNF, TP53
8MP:00053977.5MDM2, MMP9, MSH2, TNF, TP53
9MP:00036317.4MDM2, MMP9, MSH2, TNF, TP53
10MP:00053877.2MDM2, MMP9, MSH2, TNF, TP53

Publications for Actinic Cheilitis

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Articles related to Actinic Cheilitis:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Clinicopathological profile and management of 161 cases of actinic cheilitis. (26375219)
2015
2
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
3
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
4
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. (26515234)
2015
5
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. (25662549)
2015
6
Regulatory T cells in the actinic cheilitis. (25060152)
2014
7
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
8
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. (24520545)
2013
9
Erbium laser resurfacing for actinic cheilitis. (24196339)
2013
10
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. (23971281)
2013
11
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. (22714758)
2012
12
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
13
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
14
Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma. (21323960)
2011
15
Altered I^-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. (20970365)
2011
16
Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12-month follow-up study. (21916880)
2011
17
Actinic cheilitis: a case report and a review of the literature. (21228959)
2011
18
Actinic cheilitis among agricultural workers in Campinas, Brazil. (21485236)
2011
19
A case of metastatic squamous cell carcinoma arising from actinic cheilitis. (21738376)
2011
20
Actinic cheilitis: evolution to squamous cell carcinoma after carbon dioxide laser vaporization. A study of 43 cases. (19418331)
2010
21
Actinic cheilitis: a treatment review. (20964646)
2010
22
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
23
Morphology of collagen fibers and elastic system fibers in actinic cheilitis. (21187617)
2010
24
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
25
Cheilitis glandularis and actinic cheilitis: differential diagnoses - report of three unusual cases. (19281710)
2009
26
Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases. (18489592)
2008
27
Oral Pathology Quiz #61. Case number 1. Actinic cheilitis. (19177961)
2008
28
Recognition and treatment of actinic cheilitis. (18481555)
2008
29
Acute actinic cheilitis-like chemical irritant reaction following accidental contact with ethylene glycol-favorable response to topical 1% pimecrolimus cream: a case report. (18568894)
2008
30
p53 and MDM2 protein expression in actinic cheilitis. (19082401)
2008
31
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. (17640230)
2007
32
A new modality in the treatment of actinic cheilitis using the Er:YAG laser. (17506137)
2007
33
Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: report of three cases. (16188193)
2005
34
Laser-mediated photodynamic therapy of actinic cheilitis. (15552607)
2004
35
Topical 5% imiquimod for the therapy of actinic cheilitis. (12271290)
2002
36
Comparison of electrodessication with CO2 laser for the treatment of actinic cheilitis. (10759824)
2000
37
Actinic cheilitis. (9568209)
1998
38
Actinic cheilitis. A treatment review. (9107289)
1997
39
Actinic cheilitis: a premalignant condition. (9515418)
1997
40
Actinic cheilitis. (8308614)
1993
41
Carbon dioxide laser treatment for actinic cheilitis. (8336236)
1993
42
Actinic cheilitis granulomatosa. (1479115)
1992
43
Custom lip shield for chronic actinic cheilitis. (2051365)
1991
44
Actinic cheilitis. Treatment with the carbon dioxide laser. (2106386)
1990
45
Carbon dioxide laser vermilionectomy for chronic actinic cheilitis. (2487875)
1989
46
Actinic cheilitis. A prospective study comparing four treatment methods. (2736096)
1989
47
Laser vermilion ablation for actinic cheilitis. (4008733)
1985
48
Actinic cheilitis. Diagnosis, prevention, and treatment. (6983788)
1982
49
Histopathology of actinic cheilitis. (6077128)
1967
50
Labial heterotopia of the salivary glands with actinic cheilitis-a new syndrome]. (14379725)
1955

Variations for Actinic Cheilitis

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Expression for genes affiliated with Actinic Cheilitis

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Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

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Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, TP53
2
Show member pathways
9.5MDM2, TP53
3
Show member pathways
9.5MDM2, TP53
49.5MDM2, TP53
59.5MDM2, TP53
69.5MDM2, TP53
7
Show member pathways
9.5MDM2, TP53
89.5MDM2, TP53
99.5MDM2, TP53
109.5MDM2, TP53
119.5MDM2, TP53
129.5MDM2, TP53
139.5MDM2, TP53
149.5MDM2, TP53
15
Show member pathways
9.5MSH2, TP53
169.5MSH2, TP53
179.4TNF, TP53
189.0MMP9, TNF
199.0MDM2, MSH2, TP53
209.0MDM2, MSH2, TP53
21
Show member pathways
9.0MDM2, MSH2, TP53
22
Show member pathways
9.0MDM2, MSH2, TP53
239.0MDM2, MSH2, TP53
24
Show member pathways
9.0MDM2, MSH2, TP53
258.9MDM2, TNF, TP53
26
Apoptosis (WikiPathways)
Show member pathways
8.9MDM2, TNF, TP53
278.7MDM2, MMP9, TP53
288.7MDM2, MMP9, TP53
298.7MDM2, MMP9, TP53
30
Show member pathways
8.6MMP9, TNF, TP53
318.6MMP9, TNF, TP53
328.2MDM2, MMP9, MSH2, TP53
338.1MDM2, MMP9, TNF, TP53
348.1MMP9, MSH2, TNF, TP53

GO Terms for genes affiliated with Actinic Cheilitis

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Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5MDM2, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1determination of adult lifespanGO:000834010.0MSH2, TP53
2protein import into nucleus, translocationGO:000006010.0TNF, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.9MDM2, TP53
4response to X-rayGO:00101659.9MSH2, TP53
5intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.9MSH2, TP53
6response to salt stressGO:00096519.8TNF, TP53
7response to antibioticGO:00466779.8MDM2, TP53
8intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.7MSH2, TNF
9positive regulation of release of cytochrome c from mitochondriaGO:00902009.7MMP9, TP53
10negative regulation of transcription, DNA-templatedGO:00458928.9MDM2, TNF, TP53
11positive regulation of apoptotic processGO:00430658.8MMP9, TNF, TP53
12negative regulation of apoptotic processGO:00430668.7MDM2, MMP9, TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.9MDM2, TP53
2protease bindingGO:00020209.8TNF, TP53
3damaged DNA bindingGO:00036849.6MSH2, TP53
4enzyme bindingGO:00198998.7MDM2, MSH2, TP53
5identical protein bindingGO:00428028.1MDM2, MMP9, TNF, TP53

Sources for Actinic Cheilitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet