Aliases & Classifications for Actinic Cheilitis

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Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 45 65
 
Actinic Cheilosis 45

Classifications:



External Ids:

UMLS65 C0267026

Summaries for Actinic Cheilitis

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Wikipedia:68 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to herpes simplex and colorectal cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Sumoylation by RanBP2 regulates transcriptional repression and EGFR Signaling Pathway. Affiliated tissues include t cells, brain and bone, and related mouse phenotypes are limbs/digits/tail and normal.

Related Diseases for Actinic Cheilitis

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Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex30.6MDM2, SUMO1, TP53
2colorectal cancer28.1ERCC1, FGFR3, ITGB1, MDM2, MMP9, MSH2
3subglottic angioma10.5MDM2, TP53
4spindle cell liposarcoma10.5MDM2, TP53
5bone chondrosarcoma10.5SERPINB5, STAT3
6transient hypogammaglobulinemia of infancy10.4FGFR3, TP53
7vulva verrucous carcinoma10.4MDM2, MMP9, TP53
8generalized peeling skin syndrome10.4ITGB4, LAMC2
9soft tissue sarcoma childhood10.4MDM2, TNF, TP53
10cervical endometrial stromal sarcoma10.4MDM2, SERPINB5, TP53
11best1 retinopathy10.4PDCD1, TNF
12epidermolysis bullosa, junctional, non-herlitz type10.4ITGB4, LAMC2
13dilated cardiomyopathy10.4MDM2, STAT3, TP53
14mononeuritis of upper limb10.4MDM2, MMP9, STAT3
15periodic limb movement disorder10.3LAMC2, TNF, TP53
16adult astrocytic tumour10.3FGFR3, MDM2, TP53
17hepatocellular adenoma10.3MDM2, MMP9, TP53
18urinary tract papillary transitional cell benign neoplasm10.3FGFR3, TP53
19autoimmune oophoritis10.3CD274, TNF
20scrapie10.3FGFR3, TP53
21middle ear squamous cell carcinoma10.3MDM2, TP53
22acute pyelonephritis10.3ERCC1, TP53
23renal pelvis adenocarcinoma10.3ITGA3, MMP9
24cell type cancer10.3MDM2, MMP9, STAT3, TP53
25benign eccrine breast spiradenoma10.3FGFR3, MMP9, TP53
26giant cell glioblastoma10.3FGFR3, MMP9, TP53
27vulvar clear cell hidradenocarcinoma10.2STAT3, TP53
28vibratory urticaria10.2ERCC1, MMP9, TP53
29pasteurellosis10.2FGFR3, MDM2, MMP9, TP53
30cervical cancer, somatic10.2FGFR3, MDM2, MMP9, TP53
31cpt deficiency, hepatic, type ia10.1FGFR3, STAT3, TNF, TP53
32bacterial vaginosis10.1MDM2, MSH2, TP53
33prostate cancer10.1
34breast cancer10.1
35obesity10.1
36alcohol abuse10.1
37prostatitis10.1
38retinitis10.1
39tuberculosis10.1
40chronic duodenal ileus10.1MDM2, TP53
41hypothalamic disease10.1MMP9, MSH2, TP53
42esophageal cancer10.0ERCC1, MDM2, MMP9, STAT3, TP53
43familial congenital fourth cranial nerve palsy10.0MSH2, TP53
44tenosynovitis of foot and ankle10.0MMP9, MSH2, STAT3, TP53
45autosomal dominant complex spastic paraplegia type 9a10.0CTNNBIP1, MMP9, TP53
46rheumatoid arthritis10.0
47hiv-110.0
48asthma10.0
49synesthesia10.0
50renal cell carcinoma10.0

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms for Actinic Cheilitis

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Drugs & Therapeutics for Actinic Cheilitis

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Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidapprovedPhase 4, Phase 1142106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulan Kerastick
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2
Imiquimodapproved, investigationalPhase 413199011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
I06-0624
 
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
imiquimod
3Dermatologic AgentsPhase 4, Phase 14555
4Photosensitizing AgentsPhase 4, Phase 1374
5interferonsPhase 41930
6Immunologic FactorsPhase 418483
7Adjuvants, ImmunologicPhase 41783
8Methyl 5-aminolevulinatePhase 4, Phase 152

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

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Anatomical Context for Actinic Cheilitis

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MalaCards organs/tissues related to Actinic Cheilitis:

33
T cells, Brain, Bone, Liver, Heart, Prostate, Colon

Animal Models for Actinic Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Actinic Cheilitis:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5FGFR3, ITGA3, ITGB1, LAMC2, MDM2, MMP9
2MP:00028738.4APEX1, FGFR3, ITGB1, MDM2, SERPINB5, STAT3
3MP:00053708.4APEX1, ERCC1, ITGB1, MDM2, PDCD1, STAT3
4MP:00053798.1APEX1, ERCC1, ITGA3, ITGB1, MDM2, PDCD1
5MP:00053898.0APEX1, ERCC1, FGFR3, ITGB1, MDM2, MMP9
6MP:00053697.9APEX1, ERCC1, ITGB1, MDM2, MMP9, PDCD1
7MP:00053827.5CTNNBIP1, FGFR3, ITGB1, ITGB4, LAMC2, MDM2
8MP:00053857.3APEX1, ITGA3, ITGB1, ITGB4, MDM2, MMP9
9MP:00053887.3CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, LAMC2
10MP:00053917.3CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, MMP9
11MP:00053807.3APEX1, CTNNBIP1, ERCC1, ITGA3, ITGB1, MDM2
12MP:00053867.2CD274, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
13MP:00020066.8APEX1, ERCC1, FGFR3, ITGA3, ITGB1, MDM2
14MP:00053676.8CTNNBIP1, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
15MP:00107716.6CD274, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
16MP:00053976.5CD274, ERCC1, FGFR3, ITGB1, MDM2, MMP9
17MP:00053906.4CD274, CTNNBIP1, ERCC1, FGFR3, ITGB1, LAMC2
18MP:00036316.4CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, MDM2
19MP:00053816.2CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, LAMC2
20MP:00053765.9APEX1, CD274, ERCC1, FGFR3, ITGA3, ITGB1
21MP:00053875.3APEX1, CD274, ERCC1, FGFR3, ITGA3, ITGB1
22MP:00053785.3APEX1, CTNNBIP1, ERCC1, FGFR3, ITGA3, ITGB1
23MP:00053844.4APEX1, CD274, CTNNBIP1, ERCC1, FGFR3, ITGA3
24MP:00107684.3APEX1, CD274, CTNNBIP1, ERCC1, FGFR3, ITGA3

Publications for Actinic Cheilitis

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Articles related to Actinic Cheilitis:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Effects of radiological extent on neutrophil/lymphocyte ratio in pulmonary sarcoidosis. (26957274)
2016
2
Inspiratory muscle training improves aerobic capacity and pulmonary function in patients with ankylosing spondylitis: A randomized controlled study. (25810425)
2015
3
Superior vena cava syndrome with retropharyngeal edema as a complication of ventriculoatrial shunt. (26509004)
2015
4
Lymphoepithelioma-like carcinoma of the colon. (23626513)
2013
5
A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility. (23997015)
2013
6
Long-term consequences of neonatal mastitis. (22550321)
2012
7
The epidemiology and management of gynatresia in Lagos, southwest Nigeria. (22717415)
2012
8
Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production. (21705332)
2011
9
Resource use and costs of branch and central retinal vein occlusion in the elderly. (19921963)
2010
10
BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress. (20067774)
2010
11
Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. (19178937)
2009
12
Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. (18208544)
2008
13
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. (18042802)
2008
14
A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels. (18545987)
2008
15
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. (18310500)
2008
16
Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity. (18052678)
2008
17
Primary gastric Hodgkin's lymphoma expressing a B-Cell profile including Oct-2 and Bob-1 proteins. (17562619)
2007
18
Intramedullary ependymoma associated with Lhermitte-Duclos disease and Cowden syndrome. (17544575)
2007
19
Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblasts. (17875734)
2007
20
Comparison of platelet fibronectin, ADP-induced platelet aggregation and serum total nitric oxide (NOx) levels in angiographically determined coronary artery disease. (16378831)
2006
21
Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X. (16543491)
2006
22
Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors. (15868377)
2005
23
Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. (15994826)
2005
24
Glycemia influences on glucose metabolism in sepsis during hyperinsulinemic clamp. (15837776)
2005
25
Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins. (15956205)
2005
26
The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. (16321621)
2005
27
Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. (14552878)
2003
28
Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. (12353077)
2002
29
Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. (11850830)
2002
30
Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. (11802014)
2001
31
Electron microscopic immunolocalization of basic fibroblast growth factor in peripheral nerves. (11151411)
2000
32
Dynamic contrast-enhanced MR imaging of the water fraction of normal bone marrow and diffuse bone marrow disease. (11128399)
2000
33
Testosterone and leptin in a group of Chinese with and without diabetes. (11228760)
1999
34
Splenectomy induced complete remission in a patient with multicentric Castleman's disease and autoimmune hemolytic anemia. (10348152)
1999
35
Fibrinogen. (10467729)
1999
36
Selective mutism--the child who doesn't speak at school. (10429014)
1999
37
Regional odontodysplasia: report of four cases. (9524463)
1997
38
The use of angiotensin-converting enzyme inhibitors in the treatment of heart failure in hospital practice. (9338025)
1997
39
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence. (8833225)
1996
40
Three Japanese patients with Crigler-Najjar syndrome type I carry an identical nonsense mutation in the gene for UDP-glucuronosyltransferase. (8527799)
1995
41
Ezrin has properties to self-associate at the plasma membrane. (7844168)
1994
42
Apolipoprotein B-52 mutation associated with hypobetalipoproteinemia is compatible with a misaligned pairing deletion mechanism. (8354962)
1993
43
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. (1544906)
1992
44
What's new in osteoclast ontogeny? (2027819)
1991
45
Prevalence of antibodies to infectious bovine rhinotracheitis, parainfluenza 3, bovine respiratory syncytial, and bovine viral diarrhea viruses in cattle in Saskatchewan and Alberta. (17423704)
1990
46
Enteral hyperoxalosis due to therapy with a somatostatin analog]. (2298134)
1990
47
Childhood Degos disease with prominent neurological symptoms: report of a clinicopathological case. (3125241)
1988
48
Vertebrobasilar insufficiency in a patient with persistent trigeminal artery and stenosis of the ipsilateral carotid bifurcation--case report. (2460788)
1988
49
Visual and somatosensory evoked potentials and F-wave latency measurements in hereditary neuropathy with liability to pressure palsies. (6174708)
1982
50
Writers' cramp-a focal dystonia. (7104663)
1982

Variations for Actinic Cheilitis

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Expression for genes affiliated with Actinic Cheilitis

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Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

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Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0MDM2, SUMO1
29.9MDM2, STAT3, TP53
3
Show member pathways
9.8MDM2, SUMO1, TP53
4
Show member pathways
9.8MDM2, SUMO1, TP53
59.8MDM2, STAT3, SUMO1
69.8STAT3, SUMO1, TNF
79.6APEX1, MDM2, TP53
89.5FGFR3, MDM2, MMP9, TP53
99.5ITGB1, LAMC2, MMP9
109.4CD1A, ITGA3, TNF
119.3APEX1, MDM2, SUMO1, TP53
129.3ITGA3, ITGB1, MMP9
139.3ITGA3, ITGB1, ITGB4
149.3ITGA3, ITGB1, ITGB4
15
Show member pathways
9.2MDM2, MSH2, STAT3, TP53
16
Show member pathways
9.2ITGB1, LAMC2, STAT3, TNF
179.2APEX1, MMP9, TNF, TP53
189.2MDM2, MSH2, SERPINB5, TP53
19
Show member pathways
9.2MDM2, MSH2, SERPINB5, TP53
20
Show member pathways
9.2FGFR3, ITGB1, MDM2, TP53
219.2ITGA3, ITGB1, LAMC2, TP53
22
Show member pathways
9.1APEX1, MSH2, STAT3
239.1ITGA3, ITGB1, MMP9, STAT3
24
Show member pathways
9.1ITGA3, ITGB1, ITGB4, LAMC2
25
Show member pathways
9.1ITGA3, ITGB1, ITGB4, LAMC2
269.0FGFR3, MDM2, MMP9, SERPINB5, STAT3, TP53
279.0CD274, ITGB1, PDCD1, TNF
288.9MMP9, MSH2, STAT3, TNF, TP53
298.8ITGB1, MDM2, MMP9, STAT3, TNF, TP53
30
Show member pathways
8.8ITGA3, ITGB1, ITGB4, LAMC2, MMP9
31
Show member pathways
8.8ITGA3, ITGB1, ITGB4, STAT3, TNF
32
Show member pathways
8.7ITGB1, MDM2, MSH2, STAT3, TP53
33
Show member pathways
8.7FGFR3, ITGA3, ITGB1, ITGB4, STAT3
34
Show member pathways
8.6APEX1, ERCC1, MDM2, MSH2, TP53
35
Show member pathways
8.3FGFR3, ITGA3, ITGB1, ITGB4, LAMC2, MDM2
368.3FGFR3, ITGA3, ITGB1, ITGB4, LAMC2, MDM2
37
Show member pathways
8.0FGFR3, ITGA3, ITGB1, ITGB4, MDM2, STAT3
38
Show member pathways
8.0FGFR3, ITGA3, ITGB1, ITGB4, STAT3, SUMO1
397.5FGFR3, ITGA3, ITGB1, LAMC2, MDM2, MMP9
40
Show member pathways
7.4CTNNBIP1, ITGA3, ITGB1, MDM2, MMP9, STAT3

GO Terms for genes affiliated with Actinic Cheilitis

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Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00057309.3APEX1, MDM2, SUMO1, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of mitochondrial membrane permeabilityGO:004690210.6STAT3, TP53
2hemidesmosome assemblyGO:003158110.4ITGB4, LAMC2
3leukocyte tethering or rollingGO:005090110.3ITGB1, TNF
4response to X-rayGO:001016510.1ERCC1, MSH2
5response to gonadotropinGO:003469810.1ITGA3, ITGB1
6nucleotide-excision repairGO:00062899.8ERCC1, SUMO1, TP53
7cell-matrix adhesionGO:00071609.7ITGA3, ITGB1, ITGB4
8integrin-mediated signaling pathwayGO:00072299.6ITGA3, ITGB1, ITGB4
9negative regulation of apoptotic processGO:00430669.0MDM2, MMP9, PDCD1, STAT3, TP53
10leukocyte migrationGO:00509009.0ITGA3, ITGB1, MMP9, TNF

Sources for Actinic Cheilitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet