MCID: ACT093
MIFTS: 40

Actinic Cheilitis malady

Category: Rare diseases

Aliases & Classifications for Actinic Cheilitis

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Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 47 67
 
Actinic Cheilosis 47

Classifications:



Summaries for Actinic Cheilitis

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Wikipedia:70 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and chromosome 7p duplication, and has symptoms including chapping of lips, pigmentation lip and oral mucosa atrophy. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Aurora A signaling and Oncogene Induced Senescence. Affiliated tissues include t cells and salivary gland, and related mouse phenotypes are craniofacial and embryo.

Related Diseases for Actinic Cheilitis

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Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1cheilitis10.8
2chromosome 7p duplication10.3MDM2, TP53
3median neuropathy10.3MDM2, TP53
4ampulla of vater squamous cell carcinoma10.3MDM2, TP53
5multiple carboxylase deficiency10.3MDM2, TP53
6prostate calculus10.3MDM2, TP53
7kidney sarcoma10.3MDM2, TP53
8duodenum cancer10.3TNF, TP53
9vaginal yolk sac tumor10.2MDM2, TP53
10bile duct disease10.2MDM2, TP53
11spinal cord glioma10.2MDM2, TP53
12orbital lymphangioma10.2TNF, TP53
13early myoclonic encephalopathy10.2MDM2, TP53
14hypoglossal nerve neoplasm10.2MDM2, TP53
15emerinopathy10.2MDM2, TP53
16central nervous system rhabdomyosarcoma10.2MDM2, TP53
17actinic keratosis10.2TNF, TP53
18grade iii astrocytoma10.2MDM2, TP53
19mantle cell lymphoma10.2MDM2, TP53
20pediatric supratentorial ependymoma10.2TNF, TP53
21oral lichen planus10.2TNF, TP53
22placental choriocarcinoma10.2MDM2, TP53
23lung acinar adenocarcinoma10.2CDKN1A, TP53
24ureter inverted papilloma10.2CDKN1A, TP53
25mixed endometrial stromal and smooth muscle tumor10.2CDKN1A, TP53
26evans' syndrome10.2TNF, TP53
27synostosis10.2TNF, TP53
28vitamin d-dependent rickets, type i10.2MDM2, TP53
29jumping frenchmen of maine10.2TNF, TP53
30periodontal disease10.2MDM2, TP53
31fallopian tube adenosarcoma10.1MDM2, TP53
32clear cell sarcoma10.1MDM2, TP53
33gastrointestinal system cancer10.1CDKN1A, TP53
34peripheral nervous system ganglioneuroblastoma10.1CDKN1A, MDM2
35geniculate herpes zoster10.1TNF, TP53
36heart septal defect10.1TNF, TP53
37acute cholangitis10.1CDKN1A, TNF
38mixed extragonadal germ cell cancer10.1MDM2, TP53
39learning disability10.0CDKN1A, TP53
40septicemic plague10.0TNF, TP53
41rectum leiomyosarcoma10.0TNF, TP53
42colver steer godman syndrome10.0MSH2, TP53
43l-cell glucagon-like peptide producing tumor10.0MSH2, TP53
44plasma protein metabolism disease10.0TNF, TP53
45periapical granuloma9.9MSH2, TP53
46eosinophilic gastritis9.9TNF, TP53
47acne9.9
48lip cancer9.9
49atrial standstill9.9MDM2, TP53
50congenital hypomyelination neuropathy9.9MSH2, TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms for Actinic Cheilitis

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UMLS symptoms related to Actinic Cheilitis:


chapping of lips, pigmentation lip, oral mucosa atrophy

Drugs & Therapeutics for Actinic Cheilitis

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Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidapprovedPhase 4, Phase 1157106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2
Imiquimodapproved, investigationalPhase 413899011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
ZINC19632912
Zartra
Zyclara
imiquimod
3Dermatologic AgentsPhase 4, Phase 15674
4Photosensitizing AgentsPhase 4, Phase 1476
5interferonsPhase 42137
6Interferon InducersPhase 4285
7Adjuvants, ImmunologicPhase 42484
8Methyl 5-aminolevulinatePhase 4, Phase 158

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

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Anatomical Context for Actinic Cheilitis

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MalaCards organs/tissues related to Actinic Cheilitis:

35
T cells, Salivary gland

Animal Models for Actinic Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Actinic Cheilitis:

40 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.2CDKN1A, MDM2, TNF, TP53
2MP:00053809.2CDKN1A, MDM2, TNF, TP53
3MP:00053719.2CDKN1A, MDM2, TNF, TP53
4MP:00053709.2CDKN1A, MDM2, TNF, TP53
5MP:00053699.1CDKN1A, MDM2, TNF, TP53
6MP:00053848.4CDKN1A, MDM2, MSH2, TNF, TP53
7MP:00053818.4CDKN1A, MDM2, MSH2, TNF, TP53
8MP:00053978.4CDKN1A, MDM2, MSH2, TNF, TP53
9MP:00053878.4CDKN1A, MDM2, MSH2, TNF, TP53
10MP:00030128.4CDKN1A, MDM2, TNF, TP53
11MP:00107718.4CDKN1A, MDM2, MSH2, TNF, TP53
12MP:00020068.3CDKN1A, MDM2, MSH2, TNF, TP53
13MP:00036318.2CDKN1A, MDM2, MSH2, TNF, TP53

Publications for Actinic Cheilitis

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Articles related to Actinic Cheilitis:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. (27778327)
2017
2
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. (27867726)
2016
3
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. (27420649)
2016
4
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. (27579741)
2016
5
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. (27981067)
2016
6
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. (27241280)
2016
7
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. (27029007)
2016
8
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. (27159259)
2016
9
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
10
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
11
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. (26264639)
2015
12
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
13
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
14
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
15
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. (22481658)
2012
16
Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. (23230642)
2012
17
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. (21689160)
2012
18
Altered I^-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. (20970365)
2011
19
Actinic cheilitis: a case report and a review of the literature. (21228959)
2011
20
Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy. (20626536)
2011
21
Actinic cheilitis: a treatment review. (20964646)
2010
22
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
23
Treatment of actinic cheilitis with imiquimod 5% and a retractor on the lower lip: clinical and histological outcomes in 5 patients. (19836865)
2010
24
Treatment of actinic cheilitis with the Er:YAG laser. (20846565)
2010
25
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
26
Dermabrasion for actinic cheilitis. (18363728)
2008
27
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. (17640230)
2007
28
Actinic cheilitis: histopathology and p53. (16919027)
2006
29
Aphthous ulcers associated with imiquimod and the treatment of actinic cheilitis. (15692510)
2005
30
Laser-mediated photodynamic therapy of actinic cheilitis. (15552607)
2004
31
Altered cytokeratin expression in actinic cheilitis. (12680953)
2003
32
Topical 5% imiquimod for the therapy of actinic cheilitis. (12271290)
2002
33
Comparison of electrodessication with CO2 laser for the treatment of actinic cheilitis. (10759824)
2000
34
Surgical pearl: scroll-shaped electrode for electrodesiccation of actinic cheilitis. (10775862)
2000
35
Actinic cheilitis. A treatment review. (9107289)
1997
36
Actinic cheilitis: a premalignant condition. (9515418)
1997
37
Clinical advantage of the CO2 laser superpulsed mode. Treatment of verruca vulgaris, seborrheic keratoses, lentigines, and actinic cheilitis. (8034839)
1994
38
Actinic cheilitis. (8308614)
1993
39
Carbon dioxide laser treatment for actinic cheilitis. (8336236)
1993
40
Carbon dioxide laser vermilionectomy for actinic cheilitis. (8426249)
1993
41
CO 2 laser used in surgical treatment of actinic cheilitis. (10147969)
1992
42
Carbon dioxide laser treatment of actinic cheilitis. (1536077)
1992
43
Custom lip shield for chronic actinic cheilitis. (2051365)
1991
44
Carbon dioxide laser vermilionectomy for chronic actinic cheilitis. (2487875)
1989
45
Actinic cheilitis. A prospective study comparing four treatment methods. (2736096)
1989
46
Carbon dioxide laser treatment of chronic actinic cheilitis. (3142939)
1988
47
Prevention of the "prickling sensation" following surgery for actinic cheilitis. (3385051)
1988
48
Carbon dioxide laser treatment of actinic cheilitis. (3125394)
1988
49
CHRONIC ACTINIC CHEILITIS AND CANCER OF THE LOWER LIP. (14154810)
1964
50
Labial heterotopia of the salivary glands with actinic cheilitis-a new syndrome]. (14379725)
1955

Variations for Actinic Cheilitis

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Expression for genes affiliated with Actinic Cheilitis

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Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

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Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathwaysScoreTop Affiliating Genes
19.5MDM2, TP53
29.5MDM2, TP53
39.5MDM2, TP53
49.5TNF, TP53
59.4CDKN1A, TP53
69.4CDKN1A, TP53
7
Show member pathways
9.2MSH2, TP53
8
Show member pathways
9.0MDM2, TNF, TP53
98.9CDKN1A, MDM2, TP53
108.9CDKN1A, MDM2, TP53
118.9CDKN1A, MDM2, TP53
128.9CDKN1A, MDM2, TP53
13
Show member pathways
8.9CDKN1A, MDM2, TP53
14
Show member pathways
8.9CDKN1A, MDM2, TP53
15
Show member pathways
8.9CDKN1A, MDM2, TP53
168.9CDKN1A, MDM2, TP53
17
Show member pathways
8.9CDKN1A, MDM2, TP53
18
Show member pathways
8.9CDKN1A, MDM2, TP53
198.9CDKN1A, MDM2, TP53
20
Show member pathways
8.9CDKN1A, MDM2, TP53
21
Show member pathways
8.9CDKN1A, MDM2, TP53
22
Show member pathways
8.9CDKN1A, MDM2, TP53
238.9CDKN1A, MDM2, TP53
24
Show member pathways
8.9CDKN1A, MDM2, TP53
258.9CDKN1A, MDM2, TP53
268.9CDKN1A, MDM2, TP53
278.9CDKN1A, MDM2, TP53
288.9CDKN1A, MDM2, TP53
298.9CDKN1A, MDM2, TP53
30
Show member pathways
8.9CDKN1A, MDM2, TP53
31
Show member pathways
8.9CDKN1A, MDM2, TP53
328.9CDKN1A, TNF, TP53
338.9CDKN1A, TNF, TP53
348.7MDM2, MSH2, TP53
358.4CDKN1A, MDM2, TNF, TP53
368.4CDKN1A, MDM2, TNF, TP53
37
Show member pathways
8.1CDKN1A, MDM2, MSH2, TP53
38
Show member pathways
8.1CDKN1A, MDM2, MSH2, TP53
398.1CDKN1A, MDM2, MSH2, TP53
408.1CDKN1A, MDM2, MSH2, TP53
418.1CDKN1A, MDM2, MSH2, TP53
42
Show member pathways
8.1CDKN1A, MDM2, MSH2, TP53
43
Show member pathways
8.1CDKN1A, MDM2, MSH2, TP53
448.1CDKN1A, MSH2, TNF, TP53

GO Terms for genes affiliated with Actinic Cheilitis

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Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5MDM2, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein export from nucleusGO:004682710.0MDM2, TP53
2positive regulation of reactive oxygen species metabolic processGO:200037910.0CDKN1A, TP53
3cellular response to ionizing radiationGO:007147910.0CDKN1A, TP53
4response to antibioticGO:00466779.9MDM2, TP53
5replicative senescenceGO:00903999.9CDKN1A, TP53
6positive regulation of programmed cell deathGO:00430689.9CDKN1A, TNF
7response to glucocorticoidGO:00513849.9CDKN1A, TNF
8determination of adult lifespanGO:00083409.8MSH2, TP53
9cellular response to organic cyclic compoundGO:00714079.8MDM2, TNF
10intrinsic apoptotic signaling pathwayGO:00971939.7CDKN1A, TP53
11intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.7MSH2, TNF
12Ras protein signal transductionGO:00072659.5CDKN1A, TP53
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.4CDKN1A, MDM2, TP53
14response to X-rayGO:00101659.2CDKN1A, MSH2, TP53
15negative regulation of gene expressionGO:00106299.1CDKN1A, MDM2, TNF
16negative regulation of apoptotic processGO:00430669.1CDKN1A, MDM2, TP53
17intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.0CDKN1A, MSH2, TP53
18positive regulation of gene expressionGO:00106289.0MDM2, TNF, TP53
19cell cycle arrestGO:00070508.9CDKN1A, MSH2, TP53
20cellular response to DNA damage stimulusGO:00069748.9CDKN1A, MSH2, TP53
21negative regulation of transcription, DNA-templatedGO:00458928.7MDM2, TNF, TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.9MDM2, TP53
2damaged DNA bindingGO:00036849.5MSH2, TP53
3protease bindingGO:00020209.2TNF, TP53
4ubiquitin protein ligase bindingGO:00316258.8CDKN1A, MDM2, TP53
5enzyme bindingGO:00198998.7MDM2, MSH2, TP53

Sources for Actinic Cheilitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet