Aliases & Classifications for Actinic Cheilitis

About this section

Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 45 65
 
Actinic Cheilosis 45

Classifications:



External Ids:

UMLS65 C0267026

Summaries for Actinic Cheilitis

About this section
Wikipedia:68 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and subglottic angioma, and has symptoms including oral mucosa atrophy, pigmentation lip and chapping of lips. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Sumoylation by RanBP2 regulates transcriptional repression and EGFR Signaling Pathway. Affiliated tissues include brain, prostate and bone, and related mouse phenotypes are limbs/digits/tail and normal.

Related Diseases for Actinic Cheilitis

About this section

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1cheilitis10.9
2subglottic angioma10.8MDM2, TP53
3spindle cell liposarcoma10.7MDM2, TP53
4bone chondrosarcoma10.7SERPINB5, STAT3
5herpes simplex10.6MDM2, SUMO1, TP53
6transient hypogammaglobulinemia of infancy10.6FGFR3, TP53
7vulva verrucous carcinoma10.6MDM2, MMP9, TP53
8generalized peeling skin syndrome10.6ITGB4, LAMC2
9soft tissue sarcoma childhood10.6MDM2, TNF, TP53
10cervical endometrial stromal sarcoma10.6MDM2, SERPINB5, TP53
11best1 retinopathy10.6PDCD1, TNF
12epidermolysis bullosa, junctional, non-herlitz type10.6ITGB4, LAMC2
13dilated cardiomyopathy10.6MDM2, STAT3, TP53
14mononeuritis of upper limb10.5MDM2, MMP9, STAT3
15periodic limb movement disorder10.5LAMC2, TNF, TP53
16adult astrocytic tumour10.5FGFR3, MDM2, TP53
17hepatocellular adenoma10.5MDM2, MMP9, TP53
18urinary tract papillary transitional cell benign neoplasm10.5FGFR3, TP53
19autoimmune oophoritis10.5CD274, TNF
20scrapie10.5FGFR3, TP53
21middle ear squamous cell carcinoma10.4MDM2, TP53
22acute pyelonephritis10.4ERCC1, TP53
23renal pelvis adenocarcinoma10.4ITGA3, MMP9
24cell type cancer10.4MDM2, MMP9, STAT3, TP53
25benign eccrine breast spiradenoma10.4FGFR3, MMP9, TP53
26giant cell glioblastoma10.4FGFR3, MMP9, TP53
27vulvar clear cell hidradenocarcinoma10.3STAT3, TP53
28vibratory urticaria10.3ERCC1, MMP9, TP53
29pasteurellosis10.3FGFR3, MDM2, MMP9, TP53
30cervical cancer, somatic10.3FGFR3, MDM2, MMP9, TP53
31cpt deficiency, hepatic, type ia10.2FGFR3, STAT3, TNF, TP53
32bacterial vaginosis10.2MDM2, MSH2, TP53
33chronic duodenal ileus10.2MDM2, TP53
34hypothalamic disease10.1MMP9, MSH2, TP53
35esophageal cancer10.1ERCC1, MDM2, MMP9, STAT3, TP53
36familial congenital fourth cranial nerve palsy10.0MSH2, TP53
37acne10.0
38lip cancer10.0
39tenosynovitis of foot and ankle10.0MMP9, MSH2, STAT3, TP53
40autosomal dominant complex spastic paraplegia type 9a10.0CTNNBIP1, MMP9, TP53
41oculocutaneous albinism9.9
42oral squamous cell carcinoma9.9
43albinism9.9
44cheilitis glandularis9.9
45leukoplakia9.9
46atypical mole syndrome9.8APEX1, MSH2
47muscular dystrophy-dystroglycanopathy , type a, 29.8MDM2, MMP9, MSH2, STAT3, TP53
48adrenal cortical carcinoma9.7MDM2, MMP9, SERPINB5, STAT3, TNF, TP53
49factitious disorder9.6MDM2, MMP9, MSH2, SERPINB5, SUMO1, TP53
50lung cancer8.5APEX1, ERCC1, ITGA3, ITGB1, MDM2, MMP9

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms for Actinic Cheilitis

About this section

UMLS symptoms related to Actinic Cheilitis:


oral mucosa atrophy, pigmentation lip, chapping of lips

Drugs & Therapeutics for Actinic Cheilitis

About this section

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidapprovedPhase 4, Phase 1142106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulan Kerastick
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2
Imiquimodapproved, investigationalPhase 413199011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
I06-0624
 
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
imiquimod
3Dermatologic AgentsPhase 4, Phase 14555
4Photosensitizing AgentsPhase 4, Phase 1374
5interferonsPhase 41930
6Immunologic FactorsPhase 418483
7Adjuvants, ImmunologicPhase 41783
8Methyl 5-aminolevulinatePhase 4, Phase 152

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

About this section

Anatomical Context for Actinic Cheilitis

About this section

MalaCards organs/tissues related to Actinic Cheilitis:

33
Brain, Prostate, Bone, Breast, T cells, Pituitary, Skin

Animal Models for Actinic Cheilitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Actinic Cheilitis:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5FGFR3, ITGA3, ITGB1, LAMC2, MDM2, MMP9
2MP:00028738.4APEX1, FGFR3, ITGB1, MDM2, SERPINB5, STAT3
3MP:00053708.4APEX1, ERCC1, ITGB1, MDM2, PDCD1, STAT3
4MP:00053798.1APEX1, ERCC1, ITGA3, ITGB1, MDM2, PDCD1
5MP:00053898.0APEX1, ERCC1, FGFR3, ITGB1, MDM2, MMP9
6MP:00053697.9APEX1, ERCC1, ITGB1, MDM2, MMP9, PDCD1
7MP:00053827.5CTNNBIP1, FGFR3, ITGB1, ITGB4, LAMC2, MDM2
8MP:00053857.3APEX1, ITGA3, ITGB1, ITGB4, MDM2, MMP9
9MP:00053887.3CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, LAMC2
10MP:00053917.3CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, MMP9
11MP:00053807.3APEX1, CTNNBIP1, ERCC1, ITGA3, ITGB1, MDM2
12MP:00053867.2CD274, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
13MP:00020066.8APEX1, ERCC1, FGFR3, ITGA3, ITGB1, MDM2
14MP:00053676.8CTNNBIP1, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
15MP:00107716.6CD274, ERCC1, FGFR3, ITGA3, ITGB1, ITGB4
16MP:00053976.5CD274, ERCC1, FGFR3, ITGB1, MDM2, MMP9
17MP:00053906.4CD274, CTNNBIP1, ERCC1, FGFR3, ITGB1, LAMC2
18MP:00036316.4CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, MDM2
19MP:00053816.2CTNNBIP1, FGFR3, ITGA3, ITGB1, ITGB4, LAMC2
20MP:00053765.9APEX1, CD274, ERCC1, FGFR3, ITGA3, ITGB1
21MP:00053875.3APEX1, CD274, ERCC1, FGFR3, ITGA3, ITGB1
22MP:00053785.3APEX1, CTNNBIP1, ERCC1, FGFR3, ITGA3, ITGB1
23MP:00053844.4APEX1, CD274, CTNNBIP1, ERCC1, FGFR3, ITGA3
24MP:00107684.3APEX1, CD274, CTNNBIP1, ERCC1, FGFR3, ITGA3

Publications for Actinic Cheilitis

About this section

Articles related to Actinic Cheilitis:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. (26842232)
2016
2
Clinicopathological profile and management of 161 cases of actinic cheilitis. (26375219)
2015
3
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
4
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
5
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. (26515234)
2015
6
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. (25662549)
2015
7
Regulatory T cells in the actinic cheilitis. (25060152)
2014
8
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
9
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. (24520545)
2013
10
Erbium laser resurfacing for actinic cheilitis. (24196339)
2013
11
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. (23971281)
2013
12
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. (22714758)
2012
13
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
14
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
15
Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma. (21323960)
2011
16
Altered I^-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. (20970365)
2011
17
Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12-month follow-up study. (21916880)
2011
18
Actinic cheilitis: a case report and a review of the literature. (21228959)
2011
19
Actinic cheilitis among agricultural workers in Campinas, Brazil. (21485236)
2011
20
Actinic cheilitis: evolution to squamous cell carcinoma after carbon dioxide laser vaporization. A study of 43 cases. (19418331)
2010
21
Actinic cheilitis: a treatment review. (20964646)
2010
22
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
23
Morphology of collagen fibers and elastic system fibers in actinic cheilitis. (21187617)
2010
24
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
25
Cheilitis glandularis and actinic cheilitis: differential diagnoses - report of three unusual cases. (19281710)
2009
26
Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases. (18489592)
2008
27
Oral Pathology Quiz #61. Case number 1. Actinic cheilitis. (19177961)
2008
28
Recognition and treatment of actinic cheilitis. (18481555)
2008
29
Acute actinic cheilitis-like chemical irritant reaction following accidental contact with ethylene glycol-favorable response to topical 1% pimecrolimus cream: a case report. (18568894)
2008
30
p53 and MDM2 protein expression in actinic cheilitis. (19082401)
2008
31
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. (17640230)
2007
32
A new modality in the treatment of actinic cheilitis using the Er:YAG laser. (17506137)
2007
33
Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: report of three cases. (16188193)
2005
34
Laser-mediated photodynamic therapy of actinic cheilitis. (15552607)
2004
35
Topical 5% imiquimod for the therapy of actinic cheilitis. (12271290)
2002
36
Comparison of electrodessication with CO2 laser for the treatment of actinic cheilitis. (10759824)
2000
37
Actinic cheilitis. (9568209)
1998
38
Actinic cheilitis. A treatment review. (9107289)
1997
39
Actinic cheilitis: a premalignant condition. (9515418)
1997
40
Actinic cheilitis. (8308614)
1993
41
Carbon dioxide laser treatment for actinic cheilitis. (8336236)
1993
42
Actinic cheilitis granulomatosa. (1479115)
1992
43
Custom lip shield for chronic actinic cheilitis. (2051365)
1991
44
Actinic cheilitis. Treatment with the carbon dioxide laser. (2106386)
1990
45
Carbon dioxide laser vermilionectomy for chronic actinic cheilitis. (2487875)
1989
46
Actinic cheilitis. A prospective study comparing four treatment methods. (2736096)
1989
47
Laser vermilion ablation for actinic cheilitis. (4008733)
1985
48
Actinic cheilitis. Diagnosis, prevention, and treatment. (6983788)
1982
49
Histopathology of actinic cheilitis. (6077128)
1967
50
Labial heterotopia of the salivary glands with actinic cheilitis-a new syndrome]. (14379725)
1955

Variations for Actinic Cheilitis

About this section

Expression for genes affiliated with Actinic Cheilitis

About this section
Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

About this section

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0MDM2, SUMO1
29.9MDM2, STAT3, TP53
3
Show member pathways
9.8MDM2, SUMO1, TP53
4
Show member pathways
9.8MDM2, SUMO1, TP53
59.8MDM2, STAT3, SUMO1
69.8STAT3, SUMO1, TNF
79.6APEX1, MDM2, TP53
89.5FGFR3, MDM2, MMP9, TP53
99.5ITGB1, LAMC2, MMP9
109.4CD1A, ITGA3, TNF
119.3APEX1, MDM2, SUMO1, TP53
129.3ITGA3, ITGB1, MMP9
139.3ITGA3, ITGB1, ITGB4
149.3ITGA3, ITGB1, ITGB4
15
Show member pathways
9.2MDM2, MSH2, STAT3, TP53
16
Show member pathways
9.2ITGB1, LAMC2, STAT3, TNF
179.2APEX1, MMP9, TNF, TP53
189.2MDM2, MSH2, SERPINB5, TP53
19
Show member pathways
9.2MDM2, MSH2, SERPINB5, TP53
20
Show member pathways
9.2FGFR3, ITGB1, MDM2, TP53
219.2ITGA3, ITGB1, LAMC2, TP53
22
Show member pathways
9.1APEX1, MSH2, STAT3
239.1ITGA3, ITGB1, MMP9, STAT3
24
Show member pathways
9.1ITGA3, ITGB1, ITGB4, LAMC2
25
Show member pathways
9.1ITGA3, ITGB1, ITGB4, LAMC2
269.0FGFR3, MDM2, MMP9, SERPINB5, STAT3, TP53
279.0CD274, ITGB1, PDCD1, TNF
288.9MMP9, MSH2, STAT3, TNF, TP53
298.8ITGB1, MDM2, MMP9, STAT3, TNF, TP53
30
Show member pathways
8.8ITGA3, ITGB1, ITGB4, LAMC2, MMP9
31
Show member pathways
8.8ITGA3, ITGB1, ITGB4, STAT3, TNF
32
Show member pathways
8.7ITGB1, MDM2, MSH2, STAT3, TP53
33
Show member pathways
8.7FGFR3, ITGA3, ITGB1, ITGB4, STAT3
34
Show member pathways
8.6APEX1, ERCC1, MDM2, MSH2, TP53
35
Show member pathways
8.3FGFR3, ITGA3, ITGB1, ITGB4, LAMC2, MDM2
368.3FGFR3, ITGA3, ITGB1, ITGB4, LAMC2, MDM2
37
Show member pathways
8.0FGFR3, ITGA3, ITGB1, ITGB4, MDM2, STAT3
38
Show member pathways
8.0FGFR3, ITGA3, ITGB1, ITGB4, STAT3, SUMO1
397.5FGFR3, ITGA3, ITGB1, LAMC2, MDM2, MMP9

GO Terms for genes affiliated with Actinic Cheilitis

About this section

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00057309.3APEX1, MDM2, SUMO1, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of mitochondrial membrane permeabilityGO:004690210.6STAT3, TP53
2hemidesmosome assemblyGO:003158110.4ITGB4, LAMC2
3leukocyte tethering or rollingGO:005090110.3ITGB1, TNF
4response to X-rayGO:001016510.1ERCC1, MSH2
5response to gonadotropinGO:003469810.1ITGA3, ITGB1
6nucleotide-excision repairGO:00062899.8ERCC1, SUMO1, TP53
7cell-matrix adhesionGO:00071609.7ITGA3, ITGB1, ITGB4
8integrin-mediated signaling pathwayGO:00072299.6ITGA3, ITGB1, ITGB4
9negative regulation of apoptotic processGO:00430669.0MDM2, MMP9, PDCD1, STAT3, TP53
10leukocyte migrationGO:00509009.0ITGA3, ITGB1, MMP9, TNF

Sources for Actinic Cheilitis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet