Aliases & Classifications for Actinic Cheilitis

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Aliases & Descriptions for Actinic Cheilitis:

Name: Actinic Cheilitis 46 66
 
Actinic Cheilosis 46

Classifications:



Summaries for Actinic Cheilitis

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Wikipedia:69 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

MalaCards based summary: Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and chromosome 7p duplication, and has symptoms including chapping of lips, pigmentation lip and oral mucosa atrophy. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are p53 pathway (Pathway Interaction Database) and ATM Pathway. Affiliated tissues include t cells and salivary gland, and related mouse phenotypes are limbs/digits/tail and integument.

Related Diseases for Actinic Cheilitis

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Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1cheilitis10.9
2chromosome 7p duplication10.4MDM2, TP53
3median neuropathy10.4MDM2, TP53
4ampulla of vater squamous cell carcinoma10.4MDM2, TP53
5multiple carboxylase deficiency10.3MDM2, TP53
6colver steer godman syndrome10.3MSH2, TP53
7prostate calculus10.3MDM2, TP53
8kidney sarcoma10.3MDM2, TP53
9vaginal yolk sac tumor10.3MDM2, TP53
10bile duct disease10.3MDM2, TP53
11bladder verrucous squamous cell carcinoma10.3MDM2, TP53
12stampe sorensen syndrome10.3MDM2, TP53
13spinal cord glioma10.3MDM2, TP53
14l-cell glucagon-like peptide producing tumor10.3MSH2, TP53
15early myoclonic encephalopathy10.3MDM2, TP53
16hypoglossal nerve neoplasm10.3MDM2, TP53
17emerinopathy10.3MDM2, TP53
18vulvar sebaceous carcinoma10.3MDM2, TP53
19central nervous system rhabdomyosarcoma10.3MDM2, TP53
20periapical granuloma10.3MSH2, TP53
21bilateral retinoblastoma10.3MDM2, TP53
22placental choriocarcinoma10.3MDM2, TP53
23pharynx cancer10.3MDM2, TP53
24vitamin d-dependent rickets, type i10.3MDM2, TP53
25familial renal oncocytoma10.3FGFR3, TP53
26ascending colon cancer10.3MDM2, TP53
27scrapie10.3FGFR3, TP53
28intrahepatic bile duct adenoma10.3FGFR3, TP53
29periodontal disease10.2MDM2, TP53
30fallopian tube adenosarcoma10.2MDM2, TP53
31clear cell sarcoma10.2MDM2, TP53
32hypersensitivity reaction type iv disease10.2FGFR3, TP53
33multidrug-resistant tuberculosis10.2FGFR3, TP53
34congenital hypomyelination neuropathy10.2MSH2, TP53
35clove syndrome, somatic10.2FGFR3, TP53
36arrhythmogenic right ventricular cardiomyopathy10.2MSH2, TP53
37mixed extragonadal germ cell cancer10.2MDM2, TP53
38stenosis of lacrimal sac10.2MDM2, TP53
39trachea sarcoma10.2MSH2, TP53
40macular retinal edema10.2FGFR3, TP53
41tumor predisposition syndrome10.1MSH2, TP53
42lymphoplasmacytic lymphoma10.1MSH2, TP53
43penis carcinoma in situ10.1FGFR3, TP53
44atrial standstill10.1MDM2, TP53
45brain ischemia10.1MMP9, TP53
46adult mesoblastic nephroma10.1FGFR3, TP53
47malignant giant cell tumor of the tendon sheath10.0MMP9, TP53
48antidepressant or antipsychotic toxicity or dose selection10.0MMP9, TP53
49acne10.0
50lip cancer10.0

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to actinic cheilitis

Symptoms for Actinic Cheilitis

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UMLS symptoms related to Actinic Cheilitis:


chapping of lips, pigmentation lip, oral mucosa atrophy

Drugs & Therapeutics for Actinic Cheilitis

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Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidPhase 4, Phase 1150106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2interferonsPhase 42112
3
ImiquimodPhase 413599011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
ZINC19632912
Zartra
Zyclara
imiquimod

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

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Anatomical Context for Actinic Cheilitis

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MalaCards organs/tissues related to Actinic Cheilitis:

34
T cells, Salivary gland

Animal Models for Actinic Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Actinic Cheilitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.1FGFR3, MDM2, MMP9, TP53
2MP:00107718.0FGFR3, MDM2, MMP9, MSH2, TP53
3MP:00053877.9FGFR3, MDM2, MMP9, MSH2, TP53
4MP:00053677.8FGFR3, MDM2, MMP9, TP53
5MP:00053847.8FGFR3, MDM2, MMP9, MSH2, TP53
6MP:00020067.7FGFR3, MDM2, MMP9, MSH2, TP53
7MP:00053977.7FGFR3, MDM2, MMP9, MSH2, TP53
8MP:00053817.6FGFR3, MDM2, MMP9, MSH2, TP53
9MP:00036317.4FGFR3, MDM2, MMP9, MSH2, TP53

Publications for Actinic Cheilitis

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Articles related to Actinic Cheilitis:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. (27420649)
2016
2
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. (27579741)
2016
3
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. (27241280)
2016
4
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. (27029007)
2016
5
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. (27159259)
2016
6
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
7
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
8
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. (26264639)
2015
9
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. (26174644)
2015
10
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
11
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. (25400009)
2014
12
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
13
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
14
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. (22481658)
2012
15
Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. (23230642)
2012
16
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. (21689160)
2012
17
Altered I^-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. (20970365)
2011
18
Actinic cheilitis: a case report and a review of the literature. (21228959)
2011
19
Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy. (20626536)
2011
20
Actinic cheilitis: a treatment review. (20964646)
2010
21
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
22
Treatment of actinic cheilitis with imiquimod 5% and a retractor on the lower lip: clinical and histological outcomes in 5 patients. (19836865)
2010
23
Treatment of actinic cheilitis with the Er:YAG laser. (20846565)
2010
24
Photodynamic therapy with 5-aminolevulinic acid in actinic cheilitis: an 18-month clinical and histological follow-up. (20028448)
2010
25
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
26
Dermabrasion for actinic cheilitis. (18363728)
2008
27
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. (17640230)
2007
28
Actinic cheilitis: histopathology and p53. (16919027)
2006
29
Aphthous ulcers associated with imiquimod and the treatment of actinic cheilitis. (15692510)
2005
30
Laser-mediated photodynamic therapy of actinic cheilitis. (15552607)
2004
31
Altered cytokeratin expression in actinic cheilitis. (12680953)
2003
32
Topical 5% imiquimod for the therapy of actinic cheilitis. (12271290)
2002
33
Comparison of electrodessication with CO2 laser for the treatment of actinic cheilitis. (10759824)
2000
34
Surgical pearl: scroll-shaped electrode for electrodesiccation of actinic cheilitis. (10775862)
2000
35
Actinic cheilitis. A treatment review. (9107289)
1997
36
Actinic cheilitis: a premalignant condition. (9515418)
1997
37
Clinical advantage of the CO2 laser superpulsed mode. Treatment of verruca vulgaris, seborrheic keratoses, lentigines, and actinic cheilitis. (8034839)
1994
38
Actinic cheilitis. (8308614)
1993
39
Carbon dioxide laser treatment for actinic cheilitis. (8336236)
1993
40
Carbon dioxide laser vermilionectomy for actinic cheilitis. (8426249)
1993
41
CO 2 laser used in surgical treatment of actinic cheilitis. (10147969)
1992
42
Carbon dioxide laser treatment of actinic cheilitis. (1536077)
1992
43
Custom lip shield for chronic actinic cheilitis. (2051365)
1991
44
Carbon dioxide laser vermilionectomy for chronic actinic cheilitis. (2487875)
1989
45
Actinic cheilitis. A prospective study comparing four treatment methods. (2736096)
1989
46
Carbon dioxide laser treatment of chronic actinic cheilitis. (3142939)
1988
47
Prevention of the "prickling sensation" following surgery for actinic cheilitis. (3385051)
1988
48
Carbon dioxide laser treatment of actinic cheilitis. (3125394)
1988
49
CHRONIC ACTINIC CHEILITIS AND CANCER OF THE LOWER LIP. (14154810)
1964
50
Labial heterotopia of the salivary glands with actinic cheilitis-a new syndrome]. (14379725)
1955

Variations for Actinic Cheilitis

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Expression for genes affiliated with Actinic Cheilitis

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Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for genes affiliated with Actinic Cheilitis

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Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5MDM2, TP53
2
Show member pathways
9.5MDM2, TP53
39.5MDM2, TP53
49.5MDM2, TP53
59.5MDM2, TP53
6
Show member pathways
9.5MDM2, TP53
79.5MDM2, TP53
89.5MDM2, TP53
99.5MDM2, TP53
109.5MDM2, TP53
11
Show member pathways
9.5MDM2, TP53
129.5MDM2, TP53
139.5MDM2, TP53
14
Show member pathways
9.5MSH2, TP53
15
Show member pathways
9.5MSH2, TP53
169.4FGFR3, TP53
179.2MMP9, TP53
189.0FGFR3, MMP9
19
Show member pathways
9.0FGFR3, MMP9
20
Show member pathways
9.0MDM2, MSH2, TP53
219.0MDM2, MSH2, TP53
22
Show member pathways
9.0MDM2, MSH2, TP53
239.0MDM2, MSH2, TP53
24
Show member pathways
9.0MDM2, MSH2, TP53
25
Show member pathways
9.0MDM2, MSH2, TP53
269.0MDM2, MSH2, TP53
27
Show member pathways
8.9FGFR3, MDM2, TP53
288.9FGFR3, MDM2, TP53
29
Show member pathways
8.9FGFR3, MDM2, TP53
308.7MDM2, MMP9, TP53
318.7MDM2, MMP9, TP53
328.7MMP9, MSH2, TP53
338.1FGFR3, MDM2, MMP9, TP53
348.1FGFR3, MDM2, MMP9, TP53
357.5FGFR3, MDM2, MMP9, MSH2, TP53

GO Terms for genes affiliated with Actinic Cheilitis

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Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5MDM2, TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1determination of adult lifespanGO:000834010.1MSH2, TP53
2response to X-rayGO:00101659.9MSH2, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.9MDM2, TP53
4positive regulation of protein export from nucleusGO:00468279.9MDM2, TP53
5response to antibioticGO:00466779.8MDM2, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.7MSH2, TP53
7positive regulation of vascular smooth muscle cell proliferationGO:19047079.1MDM2, MMP9
8positive regulation of release of cytochrome c from mitochondriaGO:00902008.9MMP9, TP53
9negative regulation of apoptotic processGO:00430668.7MDM2, MMP9, TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.8MDM2, TP53
2damaged DNA bindingGO:00036849.6MSH2, TP53
3enzyme bindingGO:00198999.0MDM2, MSH2, TP53

Sources for Actinic Cheilitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet