Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 49 69
Actinic Cheilosis 49

Classifications:



External Ids:

UMLS 69 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and oral squamous cell carcinoma. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and Endometrial cancer. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 72 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 cheilitis 30.1 CDKN1A MDM2 MSH2 TP53
2 oral squamous cell carcinoma 29.4 CDKN1A MDM2 TP53
3 lip cancer 28.7 CDKN1A MDM2 MSH2 TP53
4 squamous cell carcinoma 10.4
5 ring chromosome 7 10.2 MDM2 TP53
6 sclerosing liposarcoma 10.2 MDM2 TP53
7 anal squamous cell carcinoma 10.2 MDM2 TP53
8 thyroid lymphoma 10.2 TNF TP53
9 lichen sclerosus 10.2 TNF TP53
10 periosteal osteogenic sarcoma 10.2 MDM2 TP53
11 dedifferentiated liposarcoma 10.2 MDM2 TP53
12 gliomatosis cerebri 10.2 MDM2 TP53
13 small cell sarcoma 10.2 MDM2 TP53
14 myxosarcoma 10.2 MDM2 TP53
15 embryonal sarcoma 10.2 MDM2 TP53
16 cellular schwannoma 10.2 MDM2 TP53
17 lichen disease 10.2 TNF TP53
18 chronic salpingitis 10.2 TNF TP53
19 adult medulloblastoma 10.2 MDM2 TP53
20 muscle cancer 10.2 MDM2 TP53
21 giant cell glioblastoma 10.1 MDM2 TP53
22 grade iii astrocytoma 10.1 MDM2 TP53
23 connective tissue cancer 10.1 MDM2 TP53
24 invasive bladder transitional cell carcinoma 10.1 CDKN1A TP53
25 bladder transitional cell papilloma 10.1 CDKN1A TP53
26 atypical follicular adenoma 10.1 CDKN1A TP53
27 atrophic gastritis 10.1 TNF TP53
28 myxoid liposarcoma 10.1 MDM2 TP53
29 suppressor of tumorigenicity 3 10.1 CDKN1A TP53
30 histiocytoma 10.1 MDM2 TP53
31 pleomorphic adenoma 10.1 MDM2 TP53
32 cystitis 10.1 TNF TP53
33 nodular ganglioneuroblastoma 10.1 CDKN1A MDM2
34 serous cystadenocarcinoma 10.1 CDKN1A TP53
35 inflammatory myofibroblastic tumor 10.1 MDM2 TP53
36 cystadenocarcinoma 10.1 CDKN1A TP53
37 intestinal disease 10.1 TNF TP53
38 tongue cancer 10.1 CDKN1A TP53
39 cervical adenocarcinoma 10.1 CDKN1A TP53
40 leiomyosarcoma 10.0 MDM2 TP53
41 suppurative cholangitis 10.0 CDKN1A TNF
42 liposarcoma 10.0 MDM2 TP53
43 breast disease 10.0 TNF TP53
44 lichen planus 10.0 TNF TP53
45 cerebral primitive neuroectodermal tumor 10.0 MSH2 TP53
46 familial colorectal cancer 9.9 MSH2 TP53
47 acquired immunodeficiency syndrome 9.9 TNF TP53
48 intestinal benign neoplasm 9.9 MSH2 TP53
49 hereditary breast ovarian cancer syndrome 9.9 MSH2 TP53
50 colorectal adenoma 9.9 MSH2 TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 TP53 MSH2 CDKN1A TNF MDM2
2 digestive/alimentary MP:0005381 9.88 CDKN1A TNF MDM2 TP53 MSH2
3 hematopoietic system MP:0005397 9.85 MSH2 CDKN1A TNF MDM2 TP53
4 immune system MP:0005387 9.83 MSH2 CDKN1A TNF MDM2 TP53
5 craniofacial MP:0005382 9.8 CDKN1A TNF MDM2 TP53
6 integument MP:0010771 9.8 MSH2 CDKN1A TNF MDM2 TP53
7 limbs/digits/tail MP:0005371 9.67 CDKN1A TNF MDM2 TP53
8 liver/biliary system MP:0005370 9.62 CDKN1A TNF MDM2 TP53
9 muscle MP:0005369 9.56 CDKN1A TNF MDM2 TP53
10 neoplasm MP:0002006 9.55 CDKN1A TNF MDM2 TP53 MSH2
11 nervous system MP:0003631 9.35 MSH2 CDKN1A TNF MDM2 TP53
12 no phenotypic analysis MP:0003012 8.92 CDKN1A TNF MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 interferons Phase 4
4 Methyl 5-aminolevulinate Phase 4,Phase 1
5 Adjuvants, Immunologic Phase 4
6 Dermatologic Agents Phase 4,Phase 1
7 Photosensitizing Agents Phase 4,Phase 1
8 Interferon Inducers Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
6 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

38
T Cells, Salivary Gland

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 138)
# Title Authors Year
1
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
2
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
3
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
4
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
5
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
6
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
7
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
8
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
9
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
10
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
11
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
12
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
13
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
14
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
15
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
16
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
17
Clinicopathological profile and management of 161 cases of actinic cheilitis. ( 26375219 )
2015
18
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. ( 26179312 )
2015
19
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. ( 25662549 )
2015
20
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015
21
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2015
22
Treatment of Actinic Cheilitis. ( 26418628 )
2015
23
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. ( 26174644 )
2015
24
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
25
Commentary on photodynamic therapy of actinic cheilitis. ( 25654194 )
2015
26
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2015
27
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
28
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015
29
Regulatory T cells in the actinic cheilitis. ( 25060152 )
2014
30
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. ( 25400009 )
2014
31
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. ( 25241153 )
2014
32
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. ( 25039599 )
2014
33
Dermoscopic features of plasma cell cheilitis and actinic cheilitis. ( 24474043 )
2014
34
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. ( 23971281 )
2013
35
Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). ( 24001384 )
2013
36
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. ( 24520545 )
2013
37
Topical photodynamic therapy may not be effective for actinic cheilitis despite repeated treatments. ( 24201136 )
2013
38
Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis. ( 23887482 )
2013
39
Erbium laser resurfacing for actinic cheilitis. ( 24196339 )
2013
40
Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia. ( 24320079 )
2013
41
Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. ( 23230642 )
2012
42
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. ( 22370573 )
2012
43
Prevalence and factors associated to actinic cheilitis in beach workers. ( 22335283 )
2012
44
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. ( 21689160 )
2012
45
Treatment of actinic cheilitis using a 1,927-nm thulium fractional laser. ( 22211447 )
2012
46
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. ( 22714758 )
2012
47
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. ( 22481658 )
2012
48
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. ( 22917688 )
2012
49
Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. ( 21612954 )
2011
50
Altered I^-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. ( 20970365 )
2011

Variations for Actinic Cheilitis

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CDKN1A MDM2 TNF TP53
2
Show member pathways
12.85 CDKN1A MDM2 MSH2 TP53
3
Show member pathways
12.77 CDKN1A MDM2 TNF TP53
4
Show member pathways
12.76 CDKN1A MDM2 MSH2 TP53
5 12.63 CDKN1A MDM2 MSH2 TP53
6
Show member pathways
12.58 CDKN1A MDM2 TNF TP53
7
Show member pathways
12.55 CDKN1A MDM2 TP53
8
Show member pathways
12.46 CDKN1A MDM2 TP53
9
Show member pathways
12.42 CDKN1A MDM2 MSH2 TP53
10
Show member pathways
12.4 CDKN1A MDM2 TP53
11
Show member pathways
12.4 CDKN1A TNF TP53
12
Show member pathways
12.4 CDKN1A MDM2 TP53
13 12.35 CDKN1A MDM2 TP53
14
Show member pathways
12.33 CDKN1A MSH2 TNF TP53
15
Show member pathways
12.31 CDKN1A MDM2 TP53
16 12.27 CDKN1A TNF TP53
17 12.25 CDKN1A MDM2 MSH2 TP53
18
Show member pathways
12.24 CDKN1A MDM2 TP53
19
Show member pathways
12.22 CDKN1A MDM2 TP53
20 12.21 CDKN1A MDM2 TP53
21 12.15 CDKN1A MDM2 TP53
22 12.15 CDKN1A MDM2 TP53
23
Show member pathways
12.11 CDKN1A MDM2 TP53
24 12.1 CDKN1A MDM2 TP53
25
Show member pathways
12.05 CDKN1A MDM2 TP53
26 12.02 CDKN1A MDM2 TP53
27 12.01 CDKN1A MDM2 TNF TP53
28 12 MDM2 MSH2 TP53
29
Show member pathways
11.99 CDKN1A MDM2 TP53
30 11.91 CDKN1A MDM2 TP53
31 11.91 CDKN1A TNF TP53
32 11.89 CDKN1A MSH2 TNF TP53
33 11.84 CDKN1A MDM2 TP53
34 11.82 CDKN1A TNF TP53
35 11.81 CDKN1A MDM2 TP53
36 11.77 CDKN1A MDM2 TP53
37 11.68 CDKN1A MDM2 TP53
38 11.68 CDKN1A MDM2 MSH2 TP53
39
Show member pathways
11.67 CDKN1A MDM2
40
Show member pathways
11.66 MSH2 TP53
41
Show member pathways
11.66 CDKN1A MDM2 TP53
42 11.63 CDKN1A MDM2 TP53
43
Show member pathways
11.6 MDM2 TP53
44 11.58 CDKN1A MDM2 MSH2 TP53
45 11.56 CDKN1A MDM2 TP53
46 11.51 MDM2 TP53
47 11.48 CDKN1A MDM2
49 11.46 MDM2 TP53
50 11.46 MDM2 TP53

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 8.8 CDKN1A MDM2 TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.84 MDM2 TNF TP53
2 negative regulation of apoptotic process GO:0043066 9.84 CDKN1A MDM2 TP53
3 cellular response to DNA damage stimulus GO:0006974 9.83 CDKN1A MSH2 TP53
4 positive regulation of gene expression GO:0010628 9.8 MDM2 TNF TP53
5 response to drug GO:0042493 9.79 CDKN1A MDM2 TP53
6 negative regulation of gene expression GO:0010629 9.73 CDKN1A MDM2 TNF
7 cellular response to organic cyclic compound GO:0071407 9.66 MDM2 TNF
8 Ras protein signal transduction GO:0007265 9.65 CDKN1A TP53
9 response to glucocorticoid GO:0051384 9.65 CDKN1A TNF
10 positive regulation of protein kinase activity GO:0045860 9.64 CDKN1A TNF
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.64 MSH2 TNF
12 response to UV GO:0009411 9.63 CDKN1A TP53
13 cell cycle arrest GO:0007050 9.63 CDKN1A MSH2 TP53
14 cellular response to heat GO:0034605 9.62 CDKN1A TP53
15 positive regulation of cell cycle GO:0045787 9.62 MDM2 TP53
16 response to organonitrogen compound GO:0010243 9.61 CDKN1A TP53
17 cellular response to ionizing radiation GO:0071479 9.6 CDKN1A TP53
18 response to antibiotic GO:0046677 9.59 MDM2 TP53
19 intrinsic apoptotic signaling pathway GO:0097193 9.58 CDKN1A TP53
20 positive regulation of reactive oxygen species metabolic process GO:2000379 9.58 CDKN1A TP53
21 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.57 MDM2 TNF
22 response to hyperoxia GO:0055093 9.55 CDKN1A TP53
23 positive regulation of protein export from nucleus GO:0046827 9.54 MDM2 TP53
24 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 CDKN1A MDM2 TP53
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.52 CDKN1A TP53
26 determination of adult lifespan GO:0008340 9.51 MSH2 TP53
27 replicative senescence GO:0090399 9.49 CDKN1A TP53
28 response to UV-B GO:0010224 9.48 MSH2 TP53
29 positive regulation of programmed cell death GO:0043068 9.43 CDKN1A TNF
30 protein kinase B signaling GO:0043491 9.43 CDKN1A MDM2 TNF
31 signal transduction by p53 class mediator GO:0072331 9.4 CDKN1A TP53
32 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
33 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
34 cellular response to gamma radiation GO:0071480 9.13 CDKN1A MDM2 TP53
35 response to X-ray GO:0010165 8.8 CDKN1A MSH2 TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.43 CDKN1A MSH2 TP53
2 p53 binding GO:0002039 9.37 MDM2 TP53
3 enzyme binding GO:0019899 9.33 MDM2 MSH2 TP53
4 damaged DNA binding GO:0003684 9.32 MSH2 TP53
5 disordered domain specific binding GO:0097718 8.96 MDM2 TP53
6 ubiquitin protein ligase binding GO:0031625 8.8 CDKN1A MDM2 TP53

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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