MCID: ACT008
MIFTS: 45

Actinic Keratosis malady

Skin diseases category

Summaries for Actinic Keratosis

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Wikipedia:63 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\"; abbreviated as \"AK\") is a... more...

MalaCards based summary: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and basal cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Apoptosis and TP53 network. The compounds eb 1089 and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and kidney, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Actinic Keratosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Actinic Keratosis, Aliases & Descriptions:

Name: Actinic Keratosis 9 11 43 60
Senile Hyperkeratosis 9
Sk - Solar Keratosis 9
 
Seborrheic Keratosis 60
Actinic Keratosis 9
Solar Keratosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Actinic Keratosis

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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.8KRT1
2basal cell carcinoma31.6TP63, CYP27B1
3retinoblastoma30.0CCNA2, CDKN2A, CDKN2B
4melanoma29.8CDKN2B, CDKN2A, GHR, TP63, CYP27B1, CCNA2
5breast cancer29.7CYP27B1, TP63, CCNA2, CDKN2A
6leukemia29.4CYP27B1, CCNA2, CDKN2B, GHR, CDKN2A
7blindness10.6
8leukoplakia10.4KRT1
9keratoacanthoma10.4
10psoriasis10.4
11superficial basal cell carcinoma10.3
12albinism10.3
13secondary hyperparathyroidism of renal origin10.3CYP27B1, GHR
14osteoporosis10.3CYP27B1, GHR
15hashimoto thyroiditis10.2CYP27B1, TP63
16oral leukoplakia10.2TP63, KRT1
17meningioma, familial10.2CDKN2B, KRT1
18neuroendocrine tumor10.2KRT1, TP63
19benign breast phyllodes tumor10.2CCNA2, TP63
20skin benign neoplasm10.2KRT1, TP63
21epidermodysplasia verruciformis10.1
22renal cell carcinoma10.1
23severe combined immunodeficiency10.1
24rosacea10.1
25lichen planus10.1
26infiltrative basal cell carcinoma10.1
27oculocutaneous albinism10.1
28merkel cell carcinoma10.1
29amyloidosis10.1
30cellulitis10.1
31cheilitis10.1
32conjunctivitis10.1
33dermatitis10.1
34lupus erythematosus10.1
35meningitis10.1
36actinic cheilitis10.1
37cheilitis glandularis10.1
38erosive pustular dermatosis of the scalp10.1
39discoid lupus erythematosus10.1
40thyroid carcinoma, papillary10.1TP63, KRT1
41transitional cell carcinoma10.1CDKN2B, TP63
42cervical squamous cell carcinoma10.1CDKN2A, TP63
43pituitary adenoma10.1GHR, CDKN2B
44anaplastic oligodendroglioma10.0CDKN2B, CDKN2A
45malignant peripheral nerve sheath tumor10.0CDKN2A, CDKN2B
46colon adenocarcinoma10.0CYP27B1, CCNA2
47precursor b-cell acute lymphoblastic leukemia10.0CDKN2A, CDKN2B
48oligodendroglioma10.0CDKN2B, CDKN2A
49bladder cancer, somatic10.0CDKN2B, CDKN2A
50esophageal cancer10.0CDKN2A, CDKN2B

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Symptoms for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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MalaCards organs/tissues related to Actinic Keratosis:

31
Skin, T cells, Kidney, Testes

Animal Models for Actinic Keratosis or affiliated genes

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Publications for Actinic Keratosis

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Articles related to Actinic Keratosis:

(show top 50)    (show all 448)
idTitleAuthorsYear
1
A study of topical methyl-aminolaevulinate red-light photodynamic therapy in the treatment of actinic keratosis in Chinese patients: a Singaporean experience. (25800146)
2015
2
Treatment of face and scalp solar (actinic) keratosis with daylight-mediated photodynamic therapy is possible throughout the year in Australia: Evidence from a clinical and meteorological study. (25827200)
2015
3
Reduced degree of irritation during a second cycle of ingenol mebutate gel 0.015% for the treatment of actinic keratosis. (25671445)
2015
4
In vivo Reflectance Confocal Microscopy Characterization of Field-Directed 5-Fluorouracil 0.5%/Salicylic Acid 10% in Actinic Keratosis. (25721522)
2015
5
High-definition optical coherence tomography algorithm for the discrimination of actinic keratosis from normal skin and from squamous cell carcinoma. (25656269)
2015
6
Possible association between actinic keratosis and the rs7208422 (c.917Aa89T, p.N306l) polymorphism of the EVER2 gene in patients without epidermodysplasia verruciformis. (25495765)
2015
7
Efficacy of imiquimod 3.75% from Lmax according to the number of actinic keratosis lesions. (25351284)
2014
8
Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis. (25349467)
2014
9
Temperature-modulated photodynamic therapy for the treatment of actinic keratosis on the extremities: a pilot study. (25207759)
2014
10
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
11
Current issues in the management of actinic keratosis. (23228304)
2013
12
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
13
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
14
Follow-up analysis of the efficacy of photodynamic therapy in actinic keratosis. (23909741)
2013
15
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
16
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
17
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
18
Monitoring blood volume and saturation using superficial fibre optic reflectance spectroscopy during PDT of actinic keratosis. (21842485)
2011
19
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
20
Actinic keratosis: facts and controversies. (20541675)
2010
21
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
22
Merkel cell carcinoma in situ associated with actinic keratosis: fortuitous or serendipitous? (20456542)
2010
23
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. (19878034)
2010
24
Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis. (19926165)
2010
25
Current and emerging treatment strategies for the treatment of actinic keratosis. (21437066)
2010
26
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
27
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
28
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
29
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
30
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
31
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
32
Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. (16243131)
2005
33
Long-term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream. (15996416)
2005
34
The use of topical imiquimod for the treatment of actinic keratosis: a status report. (16315560)
2005
35
Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. (15389189)
2004
36
Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. (15257310)
2004
37
p16INK4a expression in actinic keratosis and Bowen's disease. (14632806)
2003
38
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
39
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
40
Prevalence of solar damage and actinic keratosis in a Merseyside population. (11251601)
2001
41
Proliferative actinic keratosis: three representative cases. (10632689)
2000
42
Invasive cutaneous squamous cell carcinoma associated with actinic keratosis: a case with orbital invasion and meningeal infiltration. (10469120)
1999
43
Plasma antioxidant defense in actinic keratosis and basal cell carcinoma. (10568487)
1999
44
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. (9568428)
1998
45
Evaluation of proliferating cell nuclear antigen as a surrogate end point biomarker in actinic keratosis and adjacent, normal-appearing, and non-sun-exposed human skin samples. (9162299)
1996
46
Effect of a low-fat diet on the incidence of actinic keratosis. (8145782)
1994
47
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
48
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip. (6946379)
1981
49
Actinic keratosis and telangiectasia. (5060883)
1972
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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Pathways related to Actinic Keratosis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.2CDKN2A, TP63
2
Show member pathways
9.2TP63, CDKN2A
39.1CDKN2A, CDKN2B
4
Show member pathways
8.6CDKN2A, CCNA2, TP63
5
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
6
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
7
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
8
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
9
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
10
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
8.5CDKN2B, CDKN2A, CCNA2
11
Show member pathways
Cell cycle36
8.5CCNA2, CDKN2A, CDKN2B
128.5CDKN2B, CDKN2A, CCNA2

Compounds for genes affiliated with Actinic Keratosis

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Compounds related to Actinic Keratosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1eb 108943 5910.8CCNA2, CYP27B1
2p003439.5CDKN2B, GHR, TP63
3dihydrofolate439.5CDKN2B, CCNA2
4sodium bisulfite439.5CDKN2B, CDKN2A
55-methylcytosine43 2410.5CDKN2A, CDKN2B
65-methylthioadenosine439.5CDKN2B, CDKN2A
7isoleucine439.4GHR, KRT1
8o6-methylguanine439.4CDKN2B, CDKN2A
9hpvs439.4CDKN2A, CCNA2
10olomoucine43 1210.4CCNA2, CDKN2A
11hmba439.4CDKN2A, CCNA2
12estradiol43 24 1211.3GHR, CCNA2, CYP27B1
13bromodeoxyuridine439.3KRT1, CCNA2, TP63
14depsipeptide439.2CDKN2A, CCNA2
15chloramphenicol43 2 49 1212.2CDKN2A, GHR, CYP27B1
16roscovitine439.2CCNA2, CDKN2A
175-aza-2deoxycytidine439.2CDKN2B, CDKN2A, CYP27B1
18histidine439.1CDKN2A, GHR, TP63
19hematoxylin439.1CDKN2A, KRT1, TP63
20thymidine43 2410.1TP63, CCNA2, GHR
21selenium43 2410.0CDKN2A, CCNA2
22mg 13243 5910.0CCNA2, GHR, CDKN2A
23lysine438.9CYP27B1, TP63, CCNA2, KRT1
24zinc43 249.9CYP27B1, CCNA2, GHR, KRT1
25cytarabine43 49 1210.9CCNA2, CDKN2A, CDKN2B
26arsenite43 249.9CCNA2, CDKN2A, CDKN2B
27genistein43 28 59 2 24 1213.9CYP27B1, CCNA2, CDKN2A
28methotrexate49 43 1210.9CCNA2, CDKN2A, CDKN2B
29doxorubicin43 49 1210.8TP63, CCNA2, CDKN2A
30dopamine43 28 24 1211.7CDKN2A, GHR, CCNA2
31flavopiridol43 129.7CDKN2A, CCNA2
32cyclic amp43 249.7CYP27B1, CCNA2, GHR, CDKN2A
33cycloheximide438.7CYP27B1, CCNA2, GHR, CDKN2A
34oligonucleotide438.6CYP27B1, CCNA2, GHR, CDKN2A
35oxygen43 249.6CYP27B1, CCNA2, GHR, CDKN2A
36cisplatin43 49 59 1211.6CDKN2A, CCNA2, TP63
37glucose438.6CYP27B1, CCNA2, GHR, CDKN2A
38aspartate438.5CCNA2, GHR, KRT1, CDKN2A
39lipid438.4CDKN2A, KRT1, CCNA2, CYP27B1
40threonine438.4CDKN2B, CDKN2A, KRT1, CCNA2
41progesterone43 28 59 24 1212.1TP63, CCNA2, GHR, KRT1, CDKN2A
42arginine438.1TP63, CCNA2, GHR, KRT1, CDKN2A
43tyrosine438.0CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2B
44calcium43 49 24 1211.0CYP27B1, TP63, CCNA2, KRT1, CDKN2A
45serine438.0CDKN2B, CDKN2A, KRT1, GHR, CCNA2
46paraffin437.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
47testosterone43 59 24 1210.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
48steroid437.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
49estrogen437.2CDKN2B, CYP27B1, TP63, CCNA2, GHR, KRT1
50retinoic acid43 248.2CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A

GO Terms for genes affiliated with Actinic Keratosis

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Biological processes related to Actinic Keratosis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:00000799.4CCNA2, CDKN2B
2negative regulation of phosphorylationGO:00423269.3CDKN2B, CDKN2A
3regulation of G2/M transition of mitotic cell cycleGO:00103899.2CDKN2A, CCNA2
4response to estradiolGO:00323559.1GHR, CCNA2
5Ras protein signal transductionGO:00072658.9CCNA2, CDKN2A
6negative regulation of cell proliferationGO:00082858.9CYP27B1, CDKN2A, CDKN2B
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.7CDKN2B, CDKN2A, TP63
8mitotic cell cycleGO:00002788.6CDKN2B, CDKN2A, CCNA2
9positive regulation of transcription, DNA-templatedGO:00458938.6CDKN2A, CCNA2, TP63

Molecular functions related to Actinic Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.0CDKN2B, CDKN2A
2p53 bindingGO:00020398.9TP63, CDKN2A
3protein kinase bindingGO:00199018.1CDKN2B, CDKN2A, GHR, CCNA2
4protein bindingGO:00055157.1CDKN2B, CDKN2A, KRT1, GHR, CCNA2, TP63

Products for genes affiliated with Actinic Keratosis

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Sources for Actinic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet