MCID: ACT008
MIFTS: 53

Actinic Keratosis malady

Skin diseases category

Summaries for Actinic Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition... more...

MalaCards: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Cell Cycle and Cell cycle Transition and termination of DNA replacation. The compounds estradiol and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Actinic Keratosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

actinic keratosis 8 10 44 60
senile hyperkeratosis 8
sk - solar keratosis 8
actinic keratosis 8
solar keratosis 8


Related Diseases for Actinic Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.0KRT1
2squamous cell carcinoma31.4CCNA2, TP63, KRT1, HRAS, MCM2, CYP27B1
3basal cell carcinoma31.2S100A2, CYP27B1, TP63
4melanoma30.7TNFRSF10C, S100A6, S100A2, CCNG1, CCNA2, GHR
5skin melanoma30.6CDKN2B
6keratoacanthoma30.4PCNA
7retinoblastoma30.3CCNA2, CCNG1, CDKN2A, CDKN2B, PCNA, HRAS
8breast cancer30.2CCNA2, CCNG1, S100A6, PCNA, CYP27B1, MCM2
9lichen planus30.1KRT1
10osteosarcoma30.1CCNA2, CCNG1, S100A6, GHR, CDKN2A, CYP27B1
11skin squamous cell carcinoma10.7
12in situ carcinoma10.5
13skin disease10.4
14psoriasis10.3
15seborrheic keratosis10.3
16scalp dermatosis10.2
17superficial basal cell carcinoma10.2
18skin carcinoma in situ10.2
19rosacea10.1
20cellulitis10.1
21infiltrative basal cell carcinoma10.1
22merkel cell carcinoma10.1
23amyloidosis10.1
24cheilitis10.1
25conjunctivitis10.1
26dermatitis10.1
27hypertension10.1
28lupus erythematosus10.1
29meningitis10.1
30renal cell carcinoma10.1
31severe combined immunodeficiency10.1
32albinism10.1
33actinic cheilitis10.1
34pancreatitis10.0HRAS
35cholesteatoma10.0S100A6
36myelodysplastic syndromes10.0CDKN2B
37neurofibromatosis10.0HRAS
38thyroid cancer10.0HRAS
39gastrointestinal stromal tumor10.0PCNA
40leukoplakia10.0KRT1, PCNA
41cervical intraepithelial neoplasia10.0CDKN2A, CCNG1
42cervical squamous cell carcinoma10.0TP63, CDKN2A
43spitz nevus10.0HRAS
44oral leukoplakia10.0PCNA, KRT1, TP63
45esophageal cancer10.0CDKN2A
46smooth muscle tumor10.0PCNA, CCNA2
47adult syndrome10.0TP63
48cervical adenocarcinoma10.0CDKN2A
49colon adenocarcinoma10.0CCNA2, CYP27B1, HRAS
50pituitary adenoma10.0PCNA, CDKN2B, GHR

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Clinical Features for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Actinic Keratosis

Drug clinical trials:

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Search NIH Clinical Center for Actinic Keratosis

Search CenterWatch for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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32MalaCards
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MalaCards organs/tissues related to Actinic Keratosis:

32
Skin, Kidney, Testes, T cells

Animal Models for Actinic Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Actinic Keratosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1GHR, CDKN2A, CDKN2B, CYP27B1, HRAS
2MP:001077110.1CDKN2A, CDKN2B, CYP27B1, HRAS, KRT1
3MP:00030129.9CDKN2A, CDKN2B, PCNA, HRAS, KRT1, CNN2
4MP:00020069.7CCNG1, CDKN2A, CDKN2B, MCM2, HRAS, TP63
5MP:00053979.6CCNA2, CRLF3, GHR, CNN2, CDKN2A, CDKN2B
6MP:00053849.6TP63, CCNA2, CCNG1, DSG2, CNN2, CDKN2A
7MP:00107689.4CDKN2A, DSG2, GHR, CCNG1, CCNA2, CDKN2B
8MP:00053879.3CCNA2, GHR, CNN2, CDKN2A, CDKN2B, PCNA

Publications for Actinic Keratosis

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50PubMed
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Articles related to Actinic Keratosis:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. (24335922)
2014
2
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
3
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
4
Comparative study for the effect of photodynamic therapy, imiquimod immunotherapy and combination of both therapies on 40 lesions of actinic keratosis in Japanese patients. (24147543)
2013
5
Red light ALA-PDT for large areas of actinic keratosis is limited by severe pain and patient dissatisfaction. (24001386)
2013
6
Follow-up analysis of the efficacy of photodynamic therapy in actinic keratosis: reply from the authors. (23909766)
2013
7
Dermatology life quality index and side effects after topical photodynamic therapy of actinic keratosis. (23796769)
2013
8
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
9
Actinic keratosis: a clinical and epidemiological revision. (22714759)
2012
10
Ingenol mebutate gel 0.015% and 0.05%: in actinic keratosis. (23231025)
2012
11
Monitoring blood volume and saturation using superficial fibre optic reflectance spectroscopy during PDT of actinic keratosis. (21842485)
2011
12
The effect of increasing fluence on the treatment of actinic keratosis and photodamage by photodynamic therapy with 5-aminolevulinic acid and intense pulsed light. (21631378)
2011
13
Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma. (21091787)
2010
14
A pilot study to assess the efficacy of photodynamic therapy for Japanese patients with actinic keratosis in relation to lesion size and histological severity. (19152514)
2009
15
Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. (19467365)
2009
16
Inflammation of actinic keratosis with combination of alkylating and taxane agents: a case report. (19829884)
2009
17
Effect of dosing frequency on the safety and efficacy of imiquimod 5% cream for treatment of actinic keratosis on the forearms and hands: a phase II, randomized placebo-controlled trial. (19545297)
2009
18
Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis. (18569272)
2008
19
A phase II dose-ranging study of topical resiquimod to treat actinic keratosis. (18476957)
2008
20
Actinic keratosis. (17822489)
2007
21
Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream. (17257431)
2007
22
Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate. (16374471)
2006
23
Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis. (16405608)
2006
24
Tenascin expression in actinic keratosis. (17083689)
2006
25
Basal cell carcinoma mistaken for actinic keratosis. (16637973)
2006
26
Economic evaluation of methyl aminolaevulinate-based photodynamic therapy in the management of actinic keratosis and basal cell carcinoma. (16965429)
2006
27
The use of topical imiquimod for the treatment of actinic keratosis: a status report. (16315560)
2005
28
Pitfalls in the clinical and dermoscopic diagnosis of pigmented actinic keratosis. (16310072)
2005
29
Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double-blind, parallel-group, vehicle-controlled trials. (15837864)
2005
30
Delayed wound healing after three different treatments for widespread actinic keratosis on the atrophic bald scalp. (15209806)
2004
31
Current and novel treatment options for actinic keratosis. (15647860)
2004
32
Actinic keratosis: the key event in the evolution from photoaged skin to squamous cell carcinoma. Therapy based on pathogenetic and clinical aspects. (14976383)
2004
33
Actinic keratosis: epidemiology and progression to squamous cell carcinoma. (14616345)
2003
34
Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (12534602)
2003
35
ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapy. (12850802)
2003
36
Comparison of the microvasculature of basal cell carcinoma and actinic keratosis using intravital microscopy and immunohistochemistry. (12890202)
2003
37
Levulan: the first approved topical photosensitizer for the treatment of actinic keratosis. (12060513)
2002
38
The use of topical fluorouracil to treat actinic keratosis. (12353679)
2002
39
Photodynamic therapy with violet light and topical 6-aminolaevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma. (11843215)
2001
40
Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)
1998
41
Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice. (9187098)
1997
42
Incidence of actinic keratosis of Japanese in Kasai City, Hyogo. (9438911)
1997
43
Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression. (8594075)
1995
44
Actinic keratosis induced by use of sunbed. (8124162)
1994
45
Pruritic rash with actinic keratosis and impending exfoliation in a patient with hypertension managed with minoxidil. (2975213)
1988
46
Topical tretinoin in actinic keratosis and basal cell carcinoma. (3534022)
1986
47
Lichenoid actinic keratosis. (3950124)
1986
48
Quantitative assessment of Langerhans cells in actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma. (3763243)
1986
49
Acridine orange-DNA complex in actinic keratosis. (70537)
1977
50
Treatment of actinic keratosis. (5456030)
1970

Genetic Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MCM2
210.3MCM2
3
Hide members
10.2CDKN2B, CDKN2A, CCNA2
410.2CDKN2A, PCNA, HRAS
510.2PCNA, CCNG1, CCNA2
610.1CCNA2, CDKN2A, CDKN2B, HRAS
7
Cell cycle Cell cycle (generic schema)
Hide members
10.1PCNA, CDKN2B, CDKN2A, CCNA2
810.1TP63, HRAS, CDKN2A, CCNG1
910.1CDKN2A, CDKN2B, PCNA, HRAS
10
Hide members
10.1HRAS, CDKN2B, CCNG1, CCNA2
11
Hide members
10.0CCNA2, CDKN2A, PCNA, MCM2
12
Hide members
10.0TP63, MCM2, PCNA, CDKN2A, CCNA2
13
Hide members
9.9CCNA2, CDKN2A, CDKN2B, PCNA, MCM2
14
Hide members
9.9LMNB1, MCM2, PCNA, DSG2, CCNA2
159.9TP63, PCNA, TNFRSF10C, S100A2, CCNG1

Compounds for genes affiliated with Actinic Keratosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.7CCNA2, GHR
2tachyplesin i4410.6PCNA, CDKN2A
3olomoucine44 1111.6PCNA, CDKN2A, CCNA2
4eb 108944 5911.6CYP27B1, PCNA, CCNA2
5o6-methylguanine4410.6CDKN2A, PCNA, CDKN2B
6iudr4410.5CCNA2, PCNA
7hematoxylin4410.5CDKN2A, PCNA, KRT1, TP63
8roscovitine4410.5CDKN2A, CCNA2, PCNA
9cytarabine44 49 1112.5CDKN2B, CDKN2A, PCNA, CCNA2
10mg 13244 5911.5CCNA2, GHR, CDKN2A, PCNA
11bromodeoxyuridine4410.4PCNA, TP63, KRT1, HRAS, CCNA2
12azathioprine44 49 2 1113.4S100A6, PCNA, CDKN2B, CDKN2A
13rpa 24410.4CDKN2A, PCNA
14arsenite44 2411.4CCNA2, PCNA, CDKN2A, CDKN2B
15paclitaxel44 49 1112.4LMNB1, CCNA2, TNFRSF10C, CDKN2A, HRAS
16methotrexate44 49 1112.4CDKN2A, PCNA, CDKN2B, CCNA2
175fluorouracil4410.3TNFRSF10C, CCNA2, CDKN2A, PCNA
18genistein44 28 59 2 11 2415.3HRAS, CYP27B1, PCNA, CDKN2A, CCNA2
19etoposide44 49 59 1113.3S100A2, TNFRSF10C, PCNA, CCNA2, LMNB1
20silver4410.3S100A6, CDKN2A, PCNA
21lysine4410.3CYP27B1, CCNA2, S100A6, KRT1, TP63
22aspartate4410.3HRAS, KRT1, PCNA, CCNA2, CDKN2A, GHR
23thymidine44 2411.3GHR, HRAS, TP63, CCNA2, PCNA
245-aza-2deoxycytidine4410.3TNFRSF10C, S100A2, CDKN2A, CDKN2B, PCNA, CYP27B1
25adpribose4410.3PCNA, LMNB1, CCNA2
26cisplatin44 49 59 1113.3CCNG1, CCNA2, PCNA, TP63, CDKN2A, HRAS
27doxorubicin44 49 1112.3HRAS, CCNA2, CCNG1, TNFRSF10C, TP63, CDKN2A
28cyclic amp44 2411.3GHR, CDKN2A, CYP27B1, HRAS, CCNA2
29cetrorelix44 28 1112.3PCNA, CCNA2
30cycloheximide4410.3CYP27B1, CDKN2A, GHR, TNFRSF10C, CCNA2
31glucose4410.3HRAS, CYP27B1, CDKN2A, CCNG1
32arginine4410.2TP63, GHR, PCNA, HRAS, CDKN2A, CCNA2
33gemcitabine44 49 1112.2PCNA, HRAS, CCNA2
34h2o24410.2PCNA, HRAS, CCNA2, CDKN2A, S100A2, CCNG1
35zinc44 2411.2S100A2, GHR, CYP27B1, HRAS, KRT1, S100A6
36hydroxyurea44 49 1112.2CDKN2A, PCNA, CCNA2
37threonine4410.2CDKN2B, HRAS, MCM2, CDKN2A, CCNG1, CCNA2
38progesterone44 59 28 11 2414.1HRAS, CDKN2A, GHR, S100A6, CCNA2, KRT1
39steroid4410.1HRAS, CCNG1, S100A6, CYP27B1, GHR, CDKN2A
40oxygen44 2411.1CDKN2A, COX7C, CCNA2, HRAS, CYP27B1, GHR
41oligonucleotide4410.1CYP27B1, CDKN2A, PCNA, CCNA2, S100A2, S100A6
42lovastatin44 49 59 28 1114.1CCNA2, CDKN2A, HRAS
43cysteine4410.1HRAS, CDKN2A, LMNB1, GHR, PCNA, S100A2
44testosterone44 59 11 2413.0CDKN2A, CCNG1, PCNA, CYP27B1, CCNA2, GHR
45serine4410.0MCM2, KRT1, CCNA2, CCNG1, CDKN2A, CDKN2B
46retinoic acid44 2411.0CYP27B1, TP63, CDKN2A, KRT1, HRAS, PCNA
47paraffin449.9CCNA2, HRAS, TP63, KRT1, MCM2, CYP27B1
48p003449.9GHR, TP63, CDKN2B
49tyrosine449.9KRT1, LMNB1, CYP27B1, CDKN2B, DSG2, GHR
50calcium44 49 11 2412.9CYP27B1, HRAS, DSG2, CCNA2, S100A2, CCNG1

GO Terms for genes affiliated with Actinic Keratosis

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16Gene Ontology
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Cellular components related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.9TP63, LMNB1, MCM2, PCNA, CDKN2A, CCNA2

Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.3CDKN2B, CCNG1
2positive regulation of cell cycle arrestGO:07115810.3CDKN2A, CRLF3
3mitotic G2 DNA damage checkpointGO:00709510.2CCNA2, CCNG1
4mitotic cell cycleGO:00027810.0MCM2, PCNA, CDKN2B, CDKN2A, CCNA2
5Ras protein signal transductionGO:0072659.9HRAS, CDKN2A, CCNA2

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2B, CDKN2A
2protein kinase bindingGO:0199019.8CCNA2, GHR, CDKN2A, CDKN2B
3protein bindingGO:0055159.2CCNG1, S100A2, S100A6, GHR, CDKN2A, CDKN2B

Products for genes affiliated with Actinic Keratosis

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  • Antibodies
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Sources for Actinic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet