MCID: ACT008
MIFTS: 49

Actinic Keratosis malady

Skin category

Summaries for Actinic Keratosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition... more...

MalaCards: Actinic Keratosis, also known as senile hyperkeratosis, is related to squamous cell carcinoma and basal cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Cell Cycle and Cell cycle Transition and termination of DNA replacation. The compounds estradiol and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and t cells, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Actinic Keratosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

actinic keratosis 8 10 45 61
senile hyperkeratosis 8
sk - solar keratosis 8
actinic keratosis 8
solar keratosis 8


Related Diseases for Actinic Keratosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.4CCNA2, TP63, KRT1, HRAS, MCM2, CYP27B1
2basal cell carcinoma31.2S100A2, CYP27B1, TP63
3lichen planus30.1KRT1
4skin squamous cell carcinoma10.7
5scalp dermatosis10.2
6superficial basal cell carcinoma10.2
7anal squamous cell carcinoma10.2
8actinic cheilitis10.2
9eye carcinoma10.1
10rosacea10.1
11cellulitis10.1
12infiltrative basal cell carcinoma10.1
13skin carcinoma in situ10.1
14merkel cell carcinoma10.1
15amyloidosis10.1
16albinism10.1
17cheilitis glandularis10.1
18paget disease, extramammary10.1
19amyloidosis, secondary10.1
20actinic lichen planus10.1
21discoid lupus erythematosus10.1
22keratosis10.0KRT1
23keratoacanthoma10.0PCNA
24pancreatitis10.0HRAS
25cholesteatoma10.0S100A6
26myelodysplastic syndromes10.0CDKN2B
27neurofibromatosis10.0HRAS
28skin melanoma10.0CDKN2B
29thyroid cancer10.0HRAS
30gastrointestinal stromal tumor10.0PCNA
31leukoplakia10.0KRT1, PCNA
32cervical intraepithelial neoplasia10.0CDKN2A, CCNG1
33cervical squamous cell carcinoma10.0TP63, CDKN2A
34spitz nevus10.0HRAS
35oral leukoplakia10.0PCNA, KRT1, TP63
36esophageal cancer10.0CDKN2A
37smooth muscle tumor10.0PCNA, CCNA2
38adult syndrome10.0TP63
39cervical adenocarcinoma10.0CDKN2A
40colon adenocarcinoma10.0CCNA2, CYP27B1, HRAS
41pituitary adenoma10.0PCNA, CDKN2B, GHR
42endometrial carcinoma10.0TP63, CDKN2A, CCNA2
43acute leukemia10.0HRAS, CDKN2B, CCNA2
44phyllode tumor10.0TP63, CCNA2
45pleomorphic adenoma10.0TP63, HRAS, PCNA
46medulloblastoma10.0HRAS, CDKN2B
47trophoblastic neoplasm10.0TP63, PCNA
48multiple myeloma10.0HRAS, CDKN2A
49gastrointestinal system disease10.0HRAS
50skin benign neoplasm10.0HRAS, KRT1, TP63

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Clinical Features for Actinic Keratosis

Drugs & Therapeutics for Actinic Keratosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Actinic Keratosis

Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Search CenterWatch for Actinic Keratosis

Genetic Tests for Actinic Keratosis

Anatomical Context for Actinic Keratosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Actinic Keratosis:

33
Kidney, Skin, T cells

Animal Models for Actinic Keratosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Actinic Keratosis

Sources:
51PubMed
See all sources

Articles related to Actinic Keratosis:

(show top 50)    (show all 415)
idTitleAuthorsYear
1
Current issues in the management of actinic keratosis. (23228304)
2013
2
Basal cell carcinoma, oculo-cutaneous albinism and actinic keratosis in a native Indian. (24082183)
2013
3
Diagnostic Utility and Comparative Immunohistochemical Analysis of MITF-1 and SOX10 to Distinguish Melanoma In Situ and Actinic Keratosis: A Clinicopathological and Immunohistochemical Study of 70 Cases. (23782678)
2013
4
Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis. (24411948)
2013
5
Eyebrow hairs from actinic keratosis patients harbor the highest number of cutaneous human papillomaviruses. (23618013)
2013
6
Long-term follow-up of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis. (23528055)
2013
7
Comparative study of actinic keratosis treatment with 3% diclofenac sodium and 5% 5-fluorouracil. (24173178)
2013
8
Dermatoscopy for monitoring treatment of actinic keratosis with imiquimod. (22300301)
2012
9
Photodynamic therapy as a response to the challenge of treating actinic keratosis in the eyelid area. (23157914)
2012
10
Diclofenac sodium 3% gel for the management of actinic keratosis: 10+ years of cumulative evidence of efficacy and safety. (22527428)
2012
11
Management of periocular actinic keratosis: a review of practice patterns among ophthalmic plastic surgeons. (22785585)
2012
12
Application of photodynamic therapy combined with pre-illumination microneedling in the treatment of actinic keratosis in organ transplant recipients. (22578273)
2012
13
Risk factors for actinic keratosis in eight European centres: a case-control study. (22881586)
2012
14
Prospective comparison of three guideline development methods for treatment of actinic keratosis. (21617167)
2011
15
Current regimens and guideline implications for the treatment of actinic keratosis: proceedings of a clinical roundtable at the 2011 Winter Clinical Dermatology Conference. (21877505)
2011
16
A randomized comparative study of tolerance and satisfaction in the treatment of actinic keratosis of the face and scalp between 5% imiquimod cream and photodynamic therapy with methyl aminolaevulinate. (20973770)
2011
17
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
18
Merkel cell carcinoma in situ associated with actinic keratosis: fortuitous or serendipitous? (20456542)
2010
19
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. (19878034)
2010
20
Sebaceous carcinoma with actinic keratosis. (20169311)
2010
21
Emerging drugs for actinic keratosis. (20670178)
2010
22
Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression. (20231500)
2010
23
Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers. (19849697)
2010
24
Actinic keratosis. Patient-based approaches to adverse event management. (21319451)
2010
25
MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma. (19673870)
2009
26
Optimizing management of actinic keratosis and photodamaged skin: utilizing a stepwise approach. (19842577)
2009
27
Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells. (19175603)
2009
28
Infiltrative basal cell carcinomas presenting as actinic keratosis: implications for clinical practice. (18053057)
2008
29
Cytological diagnosis of basal cell carcinoma and actinic keratosis, using Papanicolaou and May-GrA1nwald-Giemsa stained cutaneous tissue smear. (17916094)
2008
30
Topical imiquimod therapy for actinic keratosis: is long-term clearance a realistic benefit? (21203362)
2008
31
Topical therapy in the treatment of actinic keratosis and basal cell carcinoma. (17508492)
2007
32
The characteristics of human papillomavirus expression and cell proliferation in actinic keratosis and Bowen's disease of the skin. (16905862)
2006
33
A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. (16159735)
2005
34
Update on actinic keratosis and Bowen's disease in clinical trial experience. (14616344)
2003
35
An actinic keratosis is neither malignant nor premalignant: it is an initiated tumor. (12664040)
2003
36
A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. (12775317)
2003
37
Is imiquimod effective and safe for actinic keratosis? (12620165)
2003
38
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
39
Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation. (11442750)
2001
40
A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. (11440290)
2001
41
Actinic keratosis: time to call a spade a spade. (10923970)
2000
42
Actinic keratosis. Current treatment options. (11702298)
2000
43
New treatment for actinic keratosis. (10760981)
2000
44
Immunohistochemical study of the inflammatory infiltrate associated with feline cutaneous squamous cell carcinomas and precancerous lesions (actinic keratosis). (10490233)
1999
45
Simulation of solar lentigo by spreading pigmented actinic keratosis. (7817686)
1994
46
Proliferative actinic keratosis. (8039973)
1994
47
Actinic keratosis. A premalignant skin lesion. (8433840)
1993
48
Spreading pigmented actinic keratosis. (6826809)
1983
49
Ultraviolet-induced dna repair synthesis in lymphocytes from patients with actinic keratosis. (789782)
1976
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Genetic Variations for Actinic Keratosis

Expression for genes affiliated with Actinic Keratosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MCM2
210.3MCM2
3
Hide members
10.2CDKN2B, CDKN2A, CCNA2
410.2CDKN2A, PCNA, HRAS
510.2PCNA, CCNG1, CCNA2
610.1CCNA2, CDKN2A, CDKN2B, HRAS
7
Cell cycle Cell cycle (generic schema)
Hide members
10.1PCNA, CDKN2B, CDKN2A, CCNA2
810.1TP63, HRAS, CDKN2A, CCNG1
910.1CDKN2A, CDKN2B, PCNA, HRAS
10
Hide members
10.1HRAS, CDKN2B, CCNG1, CCNA2
11
Hide members
10.0CCNA2, CDKN2A, PCNA, MCM2
12
Hide members
10.0TP63, MCM2, PCNA, CDKN2A, CCNA2
13
Hide members
9.9CCNA2, CDKN2A, CDKN2B, PCNA, MCM2
14
Hide members
9.9LMNB1, MCM2, PCNA, DSG2, CCNA2
159.9TP63, PCNA, TNFRSF10C, S100A2, CCNG1

Compounds for genes affiliated with Actinic Keratosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 29IUPHAR
See all sources

Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2412.7GHR, CCNA2
2tachyplesin i4510.6PCNA, CDKN2A
3olomoucine45 1111.6PCNA, CDKN2A, CCNA2
4eb 108945 6011.6CYP27B1, PCNA, CCNA2
5o6-methylguanine4510.6CDKN2A, CDKN2B, PCNA
6iudr4510.5PCNA, CCNA2
7hematoxylin4510.5CDKN2A, PCNA, KRT1, TP63
8roscovitine4510.5PCNA, CDKN2A, CCNA2
9cytarabine45 50 1112.5CCNA2, CDKN2A, CDKN2B, PCNA
10mg 13245 6011.5CCNA2, GHR, CDKN2A, PCNA
11bromodeoxyuridine4510.4CCNA2, PCNA, HRAS, KRT1, TP63
12azathioprine45 50 2 1113.4S100A6, CDKN2A, CDKN2B, PCNA
13rpa 24510.4PCNA, CDKN2A
14arsenite45 2411.4CCNA2, CDKN2A, CDKN2B, PCNA
15paclitaxel45 50 1112.4CCNA2, TNFRSF10C, CDKN2A, HRAS, LMNB1
16methotrexate45 50 1112.4CCNA2, CDKN2A, CDKN2B, PCNA
175fluorouracil4510.3CCNA2, TNFRSF10C, CDKN2A, PCNA
18genistein45 29 60 2 11 2415.3CCNA2, CDKN2A, PCNA, CYP27B1, HRAS
19etoposide45 50 60 1113.3CCNA2, S100A2, TNFRSF10C, PCNA, LMNB1
20silver4510.3PCNA, CDKN2A, S100A6
21lysine4510.3CCNA2, S100A6, CYP27B1, KRT1, TP63
22aspartate4510.3CCNA2, GHR, CDKN2A, PCNA, HRAS, KRT1
23thymidine45 2411.3TP63, HRAS, PCNA, GHR, CCNA2
245-aza-2deoxycytidine4510.3S100A2, TNFRSF10C, CDKN2A, CDKN2B, PCNA, CYP27B1
25adpribose4510.3CCNA2, PCNA, LMNB1
26cisplatin45 50 60 1113.3CCNA2, CCNG1, CDKN2A, PCNA, HRAS, TP63
27doxorubicin45 50 1112.3CCNA2, CCNG1, TNFRSF10C, CDKN2A, HRAS, TP63
28cyclic amp45 2411.3CCNA2, GHR, CDKN2A, CYP27B1, HRAS
29cetrorelix45 29 1112.3PCNA, CCNA2
30cycloheximide4510.3CCNA2, TNFRSF10C, GHR, CDKN2A, CYP27B1
31glucose4510.3CCNG1, CDKN2A, CYP27B1, HRAS
32arginine4510.2CCNA2, GHR, CDKN2A, PCNA, HRAS, KRT1
33gemcitabine45 50 1112.2HRAS, PCNA, CCNA2
34h2o24510.2CCNA2, CCNG1, S100A2, CDKN2A, PCNA, HRAS
35zinc45 2411.2CCNA2, S100A2, S100A6, GHR, CYP27B1, HRAS
36hydroxyurea45 50 1112.2PCNA, CDKN2A, CCNA2
37threonine4510.2CCNA2, CCNG1, CDKN2A, CDKN2B, MCM2, HRAS
38progesterone45 60 29 11 2414.1CCNA2, S100A6, GHR, CDKN2A, PCNA, HRAS
39steroid4510.1CCNA2, CCNG1, S100A6, GHR, CDKN2A, CYP27B1
40oxygen45 2411.1COX7C, CCNA2, GHR, CDKN2A, CYP27B1, HRAS
41oligonucleotide4510.1CCNA2, S100A2, S100A6, GHR, CDKN2A, PCNA
42lovastatin45 50 60 29 1114.1CCNA2, CDKN2A, HRAS
43cysteine4510.1S100A2, S100A6, GHR, CDKN2A, PCNA, CYP27B1
44testosterone45 60 11 2413.0CCNA2, CCNG1, S100A6, GHR, CDKN2A, PCNA
45serine4510.0CCNA2, CCNG1, GHR, CDKN2A, CDKN2B, MCM2
46retinoic acid45 2411.0CCNA2, S100A6, GHR, CDKN2A, CDKN2B, PCNA
47paraffin459.9TP63, CCNA2, S100A6, GHR, CDKN2A, PCNA
48p003459.9TP63, CDKN2B, GHR
49tyrosine459.9CCNA2, CCNG1, S100A2, GHR, DSG2, CDKN2B
50calcium45 50 11 2412.9CCNA2, CCNG1, S100A2, S100A6, DSG2, CDKN2A

GO Terms for genes affiliated with Actinic Keratosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.9TP63, LMNB1, MCM2, PCNA, CDKN2A, CCNA2

Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.3CDKN2B, CCNG1
2positive regulation of cell cycle arrestGO:07115810.3CDKN2A, CRLF3
3mitotic G2 DNA damage checkpointGO:00709510.2CCNA2, CCNG1
4mitotic cell cycleGO:00027810.0MCM2, PCNA, CDKN2B, CDKN2A, CCNA2
5Ras protein signal transductionGO:0072659.9HRAS, CDKN2A, CCNA2

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2B, CDKN2A
2protein kinase bindingGO:0199019.8CCNA2, GHR, CDKN2A, CDKN2B
3protein bindingGO:0055159.2CCNG1, S100A2, S100A6, GHR, CDKN2A, CDKN2B

Products for genes affiliated with Actinic Keratosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Actinic Keratosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet