MCID: ACT008
MIFTS: 53

Actinic Keratosis malady

Skin diseases category

Summaries for Actinic Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition... more...

MalaCards: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Cell Cycle and Cell cycle Transition and termination of DNA replacation. The compounds estradiol and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Actinic Keratosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

actinic keratosis 8 10 44 60
senile hyperkeratosis 8
sk - solar keratosis 8
actinic keratosis 8
solar keratosis 8


Related Diseases for Actinic Keratosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.0KRT1
2squamous cell carcinoma31.4CCNA2, TP63, KRT1, HRAS, MCM2, CYP27B1
3basal cell carcinoma31.2S100A2, CYP27B1, TP63
4melanoma30.7TNFRSF10C, S100A6, S100A2, CCNG1, CCNA2, GHR
5skin melanoma30.6CDKN2B
6keratoacanthoma30.4PCNA
7retinoblastoma30.3CCNA2, CCNG1, CDKN2A, CDKN2B, PCNA, HRAS
8breast cancer30.2CCNA2, CCNG1, S100A6, PCNA, CYP27B1, MCM2
9lichen planus30.1KRT1
10osteosarcoma30.1CCNA2, CCNG1, S100A6, GHR, CDKN2A, CYP27B1
11skin squamous cell carcinoma10.7
12in situ carcinoma10.5
13skin disease10.4
14psoriasis10.3
15seborrheic keratosis10.3
16scalp dermatosis10.2
17superficial basal cell carcinoma10.2
18skin carcinoma in situ10.2
19rosacea10.1
20cellulitis10.1
21infiltrative basal cell carcinoma10.1
22merkel cell carcinoma10.1
23amyloidosis10.1
24cheilitis10.1
25conjunctivitis10.1
26dermatitis10.1
27hypertension10.1
28lupus erythematosus10.1
29meningitis10.1
30renal cell carcinoma10.1
31severe combined immunodeficiency10.1
32albinism10.1
33actinic cheilitis10.1
34pancreatitis10.0HRAS
35cholesteatoma10.0S100A6
36myelodysplastic syndromes10.0CDKN2B
37neurofibromatosis10.0HRAS
38thyroid cancer10.0HRAS
39gastrointestinal stromal tumor10.0PCNA
40leukoplakia10.0KRT1, PCNA
41cervical intraepithelial neoplasia10.0CDKN2A, CCNG1
42cervical squamous cell carcinoma10.0TP63, CDKN2A
43spitz nevus10.0HRAS
44oral leukoplakia10.0PCNA, KRT1, TP63
45esophageal cancer10.0CDKN2A
46smooth muscle tumor10.0PCNA, CCNA2
47adult syndrome10.0TP63
48cervical adenocarcinoma10.0CDKN2A
49colon adenocarcinoma10.0CCNA2, CYP27B1, HRAS
50pituitary adenoma10.0PCNA, CDKN2B, GHR

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Clinical Features for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Actinic Keratosis

Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Search CenterWatch for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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32MalaCards
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MalaCards organs/tissues related to Actinic Keratosis:

32
Skin, Kidney, Testes, T cells

Animal Models for Actinic Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Actinic Keratosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1GHR, CDKN2A, CDKN2B, CYP27B1, HRAS
2MP:001077110.1CDKN2A, CDKN2B, CYP27B1, HRAS, KRT1
3MP:00030129.9CDKN2A, CDKN2B, PCNA, HRAS, KRT1, CNN2
4MP:00020069.7CCNG1, CDKN2A, CDKN2B, MCM2, HRAS, TP63
5MP:00053979.6CCNA2, CRLF3, GHR, CNN2, CDKN2A, CDKN2B
6MP:00053849.6TP63, CCNA2, CCNG1, DSG2, CNN2, CDKN2A
7MP:00107689.4CDKN2A, DSG2, GHR, CCNG1, CCNA2, CDKN2B
8MP:00053879.3CCNA2, GHR, CNN2, CDKN2A, CDKN2B, PCNA

Publications for Actinic Keratosis

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Sources:
50PubMed
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Articles related to Actinic Keratosis:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Morphologic grading and treatment of facial actinic keratosis. (24314380)
2014
2
Donor-derived keratinocytes in actinic keratosis and squamous cell carcinoma in patients with kidney transplant. (23190878)
2013
3
The reliability of counting actinic keratosis. (24045957)
2013
4
Lumican as a novel marker for differential diagnosis of Bowen disease and actinic keratosis. (23719483)
2013
5
Key Opinion Leader (KOL) Consensus for actinic keratosis management in Italy: the AKTUAL Workshop. (24005145)
2013
6
Photodynamic therapy with ablative carbon dioxide fractional laser in treatment of actinic keratosis. (24371387)
2013
7
Understanding actinic keratosis: epidemiology, biology, and management of the disease. (23228300)
2013
8
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
9
The interpretation of clinical studies on the photodynamic treatment of actinic keratosis. (23255880)
2012
10
New developments in the treatment of actinic keratosis: focus on ingenol mebutate gel. (22956883)
2012
11
What is the role of field-directed therapy in the treatment of actinic keratosis? Part 1: overview and investigational topical agents. (22768439)
2012
12
A review of actinic keratosis for the nurse practitioner: diagnosis, treatment, and clinical pearls. (22551333)
2012
13
Topical zinc sulphate (25%) solution: a new therapy for actinic keratosis. (22557863)
2012
14
Topical diclofenac gel for the management of periocular actinic keratosis. (21785377)
2012
15
Pitfalls of evidence-based medicine: the example of actinic keratosis therapy. (22508879)
2012
16
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. (21779166)
2011
17
Effect of retinoid pretreatment on outcomes of patients treated by photodynamic therapy for actinic keratosis of the hand and forearm. (21968662)
2011
18
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
19
Dermatology and the community nurse: actinic (solar) keratosis. (20216512)
2010
20
Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. (20725550)
2010
21
The impact of the current United States guidelines on the management of actinic keratosis: is it time for an update? (21103312)
2010
22
Differential expression of tetraspanin CD9 in basal cell and squamous cell carcinomas of the skin and actinic keratosis. (22966252)
2010
23
Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease. (19515076)
2010
24
Case-based experience in the use of 5-fluorouracil cream 0.5% as monotherapy and in conjunction with glycolic acid peels for the treatment of actinic keratosis. (20085453)
2010
25
Pharmacotherapy of actinic keratosis. (19925043)
2009
26
Effectiveness of 5-fluorouracil treatment for actinic keratosis--a systematic review of randomized controlled trials. (19416373)
2009
27
Predisposing factors of actinic keratosis in a North-West German population. (19470418)
2009
28
Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy. (18717959)
2008
29
Review of photodynamic therapy in actinic keratosis and basal cell carcinoma. (18728698)
2008
30
Actinic keratosis: from the skin to the lip. (18486781)
2008
31
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
32
Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. (17184267)
2006
33
Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. (16243131)
2005
34
Awareness, knowledge and attitudes to non-melanoma skin cancer and actinic keratosis among the general public. (15689206)
2005
35
Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome. (15606516)
2004
36
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis. (15365366)
2004
37
Primary cutaneous extraskeletal osteosarcoma under a previous electrodessicated actinic keratosis. (15577761)
2004
38
What you need to know about ... actinic keratosis. (15382535)
2004
39
Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. (15666898)
2004
40
P27 and mib1 expression in actinic keratosis, Bowen disease, and squamous cell carcinoma. (14726819)
2004
41
p16INK4a expression in actinic keratosis and Bowen's disease. (14632806)
2003
42
Photodynamic therapy for actinic keratosis followed by 5-fluorouracil reaction. (12974706)
2003
43
Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. (12582393)
2003
44
Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. (12502122)
2002
45
Sebaceous carcinoma arising on actinic keratosis. (10882948)
2000
46
Plasma antioxidant defense in actinic keratosis and basal cell carcinoma. (10568487)
1999
47
Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. (9041154)
1997
48
Actinic keratosis and squamous cell carcinoma. (8116516)
1994
49
Cycloheximide as an alternative to the use of fluorouracil for actinic keratosis. (7377799)
1980
50
Secondary localized cutaneous amyloidosis associated with actinic keratosis. (4749463)
1973

Genetic Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MCM2
210.3MCM2
3
Hide members
10.2CDKN2B, CDKN2A, CCNA2
410.2CDKN2A, PCNA, HRAS
510.2PCNA, CCNG1, CCNA2
610.1CCNA2, CDKN2A, CDKN2B, HRAS
7
Cell cycle Cell cycle (generic schema)
Hide members
10.1PCNA, CDKN2B, CDKN2A, CCNA2
810.1TP63, HRAS, CDKN2A, CCNG1
910.1CDKN2A, CDKN2B, PCNA, HRAS
10
Hide members
10.1HRAS, CDKN2B, CCNG1, CCNA2
11
Hide members
10.0CCNA2, CDKN2A, PCNA, MCM2
12
Hide members
10.0TP63, MCM2, PCNA, CDKN2A, CCNA2
13
Hide members
9.9CCNA2, CDKN2A, CDKN2B, PCNA, MCM2
14
Hide members
9.9LMNB1, MCM2, PCNA, DSG2, CCNA2
159.9TP63, PCNA, TNFRSF10C, S100A2, CCNG1

Compounds for genes affiliated with Actinic Keratosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.7GHR, CCNA2
2tachyplesin i4410.6PCNA, CDKN2A
3olomoucine44 1111.6PCNA, CDKN2A, CCNA2
4eb 108944 5911.6CYP27B1, PCNA, CCNA2
5o6-methylguanine4410.6CDKN2A, CDKN2B, PCNA
6iudr4410.5PCNA, CCNA2
7hematoxylin4410.5CDKN2A, PCNA, KRT1, TP63
8roscovitine4410.5PCNA, CDKN2A, CCNA2
9cytarabine44 49 1112.5CCNA2, CDKN2A, CDKN2B, PCNA
10mg 13244 5911.5CCNA2, GHR, CDKN2A, PCNA
11bromodeoxyuridine4410.4CCNA2, PCNA, HRAS, KRT1, TP63
12azathioprine44 49 2 1113.4S100A6, CDKN2A, CDKN2B, PCNA
13rpa 24410.4PCNA, CDKN2A
14arsenite44 2411.4CCNA2, CDKN2A, CDKN2B, PCNA
15paclitaxel44 49 1112.4CCNA2, TNFRSF10C, CDKN2A, HRAS, LMNB1
16methotrexate44 49 1112.4CCNA2, CDKN2A, CDKN2B, PCNA
175fluorouracil4410.3CCNA2, TNFRSF10C, CDKN2A, PCNA
18genistein44 28 59 2 11 2415.3CCNA2, CDKN2A, PCNA, CYP27B1, HRAS
19etoposide44 49 59 1113.3CCNA2, S100A2, TNFRSF10C, PCNA, LMNB1
20silver4410.3PCNA, CDKN2A, S100A6
21lysine4410.3CCNA2, S100A6, CYP27B1, KRT1, TP63
22aspartate4410.3CCNA2, GHR, CDKN2A, PCNA, HRAS, KRT1
23thymidine44 2411.3TP63, HRAS, PCNA, GHR, CCNA2
245-aza-2deoxycytidine4410.3S100A2, TNFRSF10C, CDKN2A, CDKN2B, PCNA, CYP27B1
25hpvs4410.3CDKN2A, CCNA2
26adpribose4410.3CCNA2, PCNA, LMNB1
27cisplatin44 49 59 1113.3CCNA2, CCNG1, CDKN2A, PCNA, HRAS, TP63
28doxorubicin44 49 1112.3CCNA2, CCNG1, TNFRSF10C, CDKN2A, HRAS, TP63
29cyclic amp44 2411.3CCNA2, GHR, CDKN2A, CYP27B1, HRAS
30cycloheximide4410.3CCNA2, TNFRSF10C, GHR, CDKN2A, CYP27B1
31glucose4410.3CCNG1, CDKN2A, CYP27B1, HRAS
32arginine4410.2CCNA2, GHR, CDKN2A, PCNA, HRAS, KRT1
33gemcitabine44 49 1112.2HRAS, PCNA, CCNA2
34h2o24410.2CCNA2, CCNG1, S100A2, CDKN2A, PCNA, HRAS
35zinc44 2411.2CCNA2, S100A2, S100A6, GHR, CYP27B1, HRAS
36hydroxyurea44 49 1112.2PCNA, CDKN2A, CCNA2
37threonine4410.2CCNA2, CCNG1, CDKN2A, CDKN2B, MCM2, HRAS
38progesterone44 59 28 11 2414.1CCNA2, S100A6, GHR, CDKN2A, PCNA, HRAS
39steroid4410.1CCNA2, CCNG1, S100A6, GHR, CDKN2A, CYP27B1
40oxygen44 2411.1COX7C, CCNA2, GHR, CDKN2A, CYP27B1, HRAS
41oligonucleotide4410.1CCNA2, S100A2, S100A6, GHR, CDKN2A, PCNA
42lovastatin44 49 59 28 1114.1CCNA2, CDKN2A, HRAS
43cysteine4410.1S100A2, S100A6, GHR, CDKN2A, PCNA, CYP27B1
44testosterone44 59 11 2413.0CCNA2, CCNG1, S100A6, GHR, CDKN2A, PCNA
45serine4410.0CCNA2, CCNG1, GHR, CDKN2A, CDKN2B, MCM2
46retinoic acid44 2411.0CCNA2, S100A6, GHR, CDKN2A, CDKN2B, PCNA
47paraffin449.9TP63, CCNA2, S100A6, GHR, CDKN2A, PCNA
48p003449.9TP63, CDKN2B, GHR
49tyrosine449.9CCNA2, CCNG1, S100A2, GHR, DSG2, CDKN2B
50calcium44 49 11 2412.9CCNA2, CCNG1, S100A2, S100A6, DSG2, CDKN2A

GO Terms for genes affiliated with Actinic Keratosis

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Sources:
16Gene Ontology
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Cellular components related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.9TP63, LMNB1, MCM2, PCNA, CDKN2A, CCNA2

Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.3CDKN2B, CCNG1
2positive regulation of cell cycle arrestGO:07115810.3CDKN2A, CRLF3
3mitotic G2 DNA damage checkpointGO:00709510.2CCNA2, CCNG1
4mitotic cell cycleGO:00027810.0MCM2, PCNA, CDKN2B, CDKN2A, CCNA2
5Ras protein signal transductionGO:0072659.9HRAS, CDKN2A, CCNA2

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2B, CDKN2A
2protein kinase bindingGO:0199019.8CCNA2, GHR, CDKN2A, CDKN2B
3protein bindingGO:0055159.2CCNG1, S100A2, S100A6, GHR, CDKN2A, CDKN2B

Products for genes affiliated with Actinic Keratosis

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  • Antibodies
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Sources for Actinic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet