MCID: ACT008
MIFTS: 53

Actinic Keratosis malady

Skin diseases, Cancer diseases categories

Summaries for Actinic Keratosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition... more...

MalaCards: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and basal cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Apoptosis and TP53 network. The compounds eb 1089 and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Actinic Keratosis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

actinic keratosis 9 11 46 63
senile hyperkeratosis 9
sk - solar keratosis 9
actinic keratosis 9
solar keratosis 9


Related Diseases for Actinic Keratosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.3KRT1
2basal cell carcinoma31.3TP63, CYP27B1
3melanoma30.6CDKN2B, CDKN2A, GHR, TP63, CYP27B1, CCNA2
4retinoblastoma30.3CCNA2, CDKN2A, CDKN2B
5breast cancer30.1CYP27B1, TP63, CCNA2, CDKN2A
6osteosarcoma30.1CYP27B1, CDKN2A, GHR, CCNA2
7blindness10.6
8keratoacanthoma10.4
9psoriasis10.4
10seborrheic keratosis10.4
11superficial basal cell carcinoma10.3
12rosacea10.1
13lichen planus10.1
14infiltrative basal cell carcinoma10.1
15merkel cell carcinoma10.1
16amyloidosis10.1
17cellulitis10.1
18cheilitis10.1
19conjunctivitis10.1
20dermatitis10.1
21hypertension10.1
22lupus erythematosus10.1
23meningitis10.1
24renal cell carcinoma10.1
25severe combined immunodeficiency10.1
26albinism10.1
27actinic cheilitis10.1
28cheilitis glandularis10.1
29erosive pustular dermatosis of the scalp10.1
30discoid lupus erythematosus10.1
31leukoplakia10.1KRT1
32secondary hyperparathyroidism of renal origin10.1CYP27B1, GHR
33osteoporosis, postmenopausal10.1CYP27B1, GHR
34autoimmune thyroiditis10.1CYP27B1, TP63
35oral leukoplakia10.1TP63, KRT1
36meningioma10.0CDKN2B, KRT1
37neuroendocrine carcinoma10.0KRT1, TP63
38phyllode tumor10.0CCNA2, TP63
39skin benign neoplasm10.0KRT1, TP63
40papillary thyroid carcinoma10.0TP63, KRT1
41transitional cell carcinoma10.0CDKN2B, TP63
42cervical squamous cell carcinoma10.0CDKN2A, TP63
43pituitary adenoma10.0GHR, CDKN2B
44anaplastic oligodendroglioma10.0CDKN2B, CDKN2A
45malignant peripheral nerve sheath tumor10.0CDKN2A, CDKN2B
46colon adenocarcinoma10.0CYP27B1, CCNA2
47leukemia, acute lymphoblastic 310.0CDKN2A, CDKN2B
48oligodendroglioma10.0CDKN2B, CDKN2A
49bladder carcinoma10.0CDKN2B, CDKN2A
50esophageal cancer10.0CDKN2A, CDKN2B

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Symptoms for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Actinic Keratosis

Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Search CenterWatch for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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34MalaCards
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MalaCards organs/tissues related to Actinic Keratosis:

34
Skin, Kidney, Testes, T cells

Animal Models for Actinic Keratosis or affiliated genes

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Sources:
38MGI
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Publications for Actinic Keratosis

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Sources:
53PubMed
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Articles related to Actinic Keratosis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer. (24332494)
2014
2
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
3
Current issues in the management of actinic keratosis. (23228304)
2013
4
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
5
Pharmacotherapeutic management of actinic keratosis: focus on newer topical agents. (23640424)
2013
6
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
7
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
8
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
9
Monitoring blood volume and saturation using superficial fibre optic reflectance spectroscopy during PDT of actinic keratosis. (21842485)
2011
10
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
11
Actinic keratosis: facts and controversies. (20541675)
2010
12
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
13
Merkel cell carcinoma in situ associated with actinic keratosis: fortuitous or serendipitous? (20456542)
2010
14
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. (19878034)
2010
15
Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis. (19926165)
2010
16
Current and emerging treatment strategies for the treatment of actinic keratosis. (21437066)
2010
17
Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma. (21091787)
2010
18
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
19
A pilot study to assess the efficacy of photodynamic therapy for Japanese patients with actinic keratosis in relation to lesion size and histological severity. (19152514)
2009
20
Dermacase. Actinic keratosis. (18474700)
2008
21
Infiltrative basal cell carcinomas presenting as actinic keratosis: implications for clinical practice. (18053057)
2008
22
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
23
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
24
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
25
Microarray analysis of aberrant gene expression in actinic keratosis: effect of the Toll-like receptor-7 agonist imiquimod. (17944981)
2007
26
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
27
The characteristics of human papillomavirus expression and cell proliferation in actinic keratosis and Bowen's disease of the skin. (16905862)
2006
28
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
29
Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. (16243131)
2005
30
Long-term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream. (15996416)
2005
31
The use of topical imiquimod for the treatment of actinic keratosis: a status report. (16315560)
2005
32
Topical photodynamic therapy using intense pulsed light for treatment of actinic keratosis: clinical and histopathologic evaluation. (15720093)
2005
33
Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. (15389189)
2004
34
Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. (15257310)
2004
35
p16INK4a expression in actinic keratosis and Bowen's disease. (14632806)
2003
36
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
37
Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis. (12271300)
2002
38
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
39
Prevalence of solar damage and actinic keratosis in a Merseyside population. (11251601)
2001
40
Proliferative actinic keratosis: three representative cases. (10632689)
2000
41
Invasive cutaneous squamous cell carcinoma associated with actinic keratosis: a case with orbital invasion and meningeal infiltration. (10469120)
1999
42
Plasma antioxidant defense in actinic keratosis and basal cell carcinoma. (10568487)
1999
43
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. (9568428)
1998
44
Evaluation of proliferating cell nuclear antigen as a surrogate end point biomarker in actinic keratosis and adjacent, normal-appearing, and non-sun-exposed human skin samples. (9162299)
1996
45
Effect of a low-fat diet on the incidence of actinic keratosis. (8145782)
1994
46
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
47
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip. (6946379)
1981
48
DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis. (686819)
1978
49
Actinic keratosis and telangiectasia. (5060883)
1972
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology, 54QIAGEN, 61Thomson Reuters, 31KEGG
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Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.2CDKN2A, TP63
2
Show member pathways
9.2TP63, CDKN2A
39.1CDKN2A, CDKN2B
4
Show member pathways
8.6CCNA2, TP63, CDKN2A
5
Show member pathways
8.5CDKN2B, CCNA2, CDKN2A
6
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
7
Show member pathways
8.5CCNA2, CDKN2A, CDKN2B
8
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
8.5CDKN2B, CDKN2A, CCNA2
9
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
10
Show member pathways
Cell cycle39
8.5CCNA2, CDKN2A, CDKN2B
11
Show member pathways
8.5CCNA2, CDKN2B, CDKN2A
128.5CCNA2, CDKN2B, CDKN2A

Compounds for genes affiliated with Actinic Keratosis

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Sources:
46Novoseek, 62Tocris Bioscience, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB, 30IUPHAR
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Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1eb 108946 6210.8CCNA2, CYP27B1
2p003469.5TP63, GHR, CDKN2B
3dihydrofolate469.5CCNA2, CDKN2B
4sodium bisulfite469.5CDKN2A, CDKN2B
55-methylcytosine46 2510.5CDKN2B, CDKN2A
65-methylthioadenosine469.5CDKN2B, CDKN2A
7isoleucine469.4GHR, KRT1
8o6-methylguanine469.4CDKN2B, CDKN2A
9hpvs469.4CCNA2, CDKN2A
10olomoucine46 1210.4CDKN2A, CCNA2
11hmba469.4CCNA2, CDKN2A
12estradiol46 25 1211.3CYP27B1, GHR, CCNA2
13bromodeoxyuridine469.3TP63, CCNA2, KRT1
14depsipeptide469.2CCNA2, CDKN2A
15chloramphenicol46 3 52 1212.2CYP27B1, GHR, CDKN2A
16roscovitine469.2CDKN2A, CCNA2
175-aza-2deoxycytidine469.2CYP27B1, CDKN2A, CDKN2B
18histidine469.1GHR, TP63, CDKN2A
19hematoxylin469.1CDKN2A, KRT1, TP63
20thymidine46 2510.1CCNA2, GHR, TP63
21selenium46 2510.0CCNA2, CDKN2A
22mg 13246 6210.0CDKN2A, CCNA2, GHR
23lysine468.9CCNA2, CYP27B1, TP63, KRT1
24zinc46 259.9KRT1, CCNA2, CYP27B1, GHR
25cytarabine46 52 1210.9CCNA2, CDKN2A, CDKN2B
26arsenite46 259.9CCNA2, CDKN2A, CDKN2B
27genistein46 30 62 3 25 1213.9CDKN2A, CYP27B1, CCNA2
28methotrexate52 46 1210.9CCNA2, CDKN2A, CDKN2B
29doxorubicin46 52 1210.8CCNA2, CDKN2A, TP63
30dopamine46 30 25 1211.7CDKN2A, GHR, CCNA2
31flavopiridol46 129.7CDKN2A, CCNA2
32cyclic amp46 259.7CYP27B1, CCNA2, GHR, CDKN2A
33cycloheximide468.7GHR, CCNA2, CYP27B1, CDKN2A
34oligonucleotide468.6CYP27B1, GHR, CDKN2A, CCNA2
35oxygen46 259.6CDKN2A, CYP27B1, CCNA2, GHR
36cisplatin46 52 62 1211.6TP63, CDKN2A, CCNA2
37glucose468.6GHR, CCNA2, CDKN2A, CYP27B1
38aspartate468.5KRT1, CDKN2A, GHR, CCNA2
39lipid468.4CCNA2, KRT1, CDKN2A, CYP27B1
40threonine468.4CCNA2, CDKN2B, CDKN2A, KRT1
41progesterone46 30 62 25 1212.1TP63, CCNA2, GHR, KRT1, CDKN2A
42arginine468.1CCNA2, GHR, TP63, CDKN2A, KRT1
43tyrosine468.0KRT1, CDKN2B, GHR, CCNA2, TP63, CYP27B1
44calcium46 52 25 1211.0CYP27B1, TP63, CCNA2, KRT1, CDKN2A
45serine468.0CDKN2B, KRT1, GHR, CDKN2A, CCNA2
46paraffin467.7CYP27B1, CDKN2A, KRT1, GHR, TP63, CCNA2
47testosterone46 62 25 1210.7KRT1, CDKN2A, GHR, CCNA2, TP63, CYP27B1
48steroid467.7CDKN2A, KRT1, GHR, CCNA2, CYP27B1, TP63
49estrogen467.2CDKN2A, CCNA2, GHR, KRT1, CYP27B1, CDKN2B
50retinoic acid46 258.2KRT1, CYP27B1, TP63, CCNA2, CDKN2B, CDKN2A

GO Terms for genes affiliated with Actinic Keratosis

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17Gene Ontology
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Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CDKN2B, CCNA2
2negative regulation of phosphorylationGO:0423269.3CDKN2A, CDKN2B
3regulation of G2/M transition of mitotic cell cycleGO:0103899.2CCNA2, CDKN2A
4response to estradiolGO:0323559.1CCNA2, GHR
5Ras protein signal transductionGO:0072658.9CCNA2, CDKN2A
6negative regulation of cell proliferationGO:0082858.9CDKN2B, CDKN2A, CYP27B1
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.7CDKN2B, CDKN2A, TP63
8mitotic cell cycleGO:0002788.6CDKN2B, CDKN2A, CCNA2
9positive regulation of transcription, DNA-templatedGO:0458938.6CDKN2A, TP63, CCNA2

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.0CDKN2B, CDKN2A
2p53 bindingGO:0020398.9CDKN2A, TP63
3protein kinase bindingGO:0199018.1CCNA2, GHR, CDKN2A, CDKN2B
4protein bindingGO:0055157.1KRT1, CCNA2, TP63, CDKN2A, CDKN2B, GHR

Products for genes affiliated with Actinic Keratosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Actinic Keratosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet