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MCID: ACT008

Actinic Keratosis malady
44 genes, 3 tissues, 535 related diseases, 26 phenotypes, 32 articles, clinical trials.

Summaries for Actinic Keratosis

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44Wikipedia, 22MalaCards
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Wikipedia: Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition...44 more...

MalaCards: Actinic Keratosis, also known as actinic keratosis (morphologic abnormality), is related to basal cell carcinoma and breast cancer. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Signal transduction_PTEN pathway and Transcription P53 signaling pathway. The compounds h2o2 and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions for Actinic Keratosis

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 19ICD9CM, 24MeSH, 27NCIt
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Aliases & Descriptions:

actinic keratosis 6 8 32 43
actinic keratosis (morphologic abnormality) 6
actinic keratosis (disorder) 6
actinic (solar) keratosis 6
senile hyperkeratosis 6
sk - solar keratosis 6
solar keratosis 6

Related Diseases for Actinic Keratosis

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13GeneCards, 14GeneDecks
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Diseases related to actinic keratosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 532)
idRelated DiseaseScoreTop Affiliating Genes
1basal cell carcinoma28.5BCL2, S100A2, MMP1, MMP3, MKI67, FASLG
2breast cancer27.8BCL2, MMP1, MMP2, MMP3, TP53, CTNNB1
3keratoacanthoma27.1PCNA, BCL2, MMP1, MKI67, CCNA2, TP53
4squamous cell carcinoma24.4PCNA, RB1, MYC, BCL2, S100A2, S100A6
5keratosis23.6KIN, PCNA, RB1, LMNA, LMNB1, MYC
6retinoblastoma23.2PCNA, RB1, LMNA, MYC, BCL2, CEACAM5
7carcinoma22.2PCNA, RB1, LMNA, LMNB1, MYC, BCL2
8pulmonary large cell neuroendocrine carcinoma13.5CDKN2A, TP63, KRT7
9breast malignant phyllodes tumor13.5MKI67, CCNA2, TP63
10hereditary mucosal leukokeratosis13.5PCNA, MKI67, TP63, KRT1
11neuroendocrine carcinoma13.5CEACAM5, TP63, KRT7, KRT1
12papillary craniopharyngioma13.4CTNNB1, KRT7
13breast fibroadenoma13.4PCNA, MKI67, TP63
14bowen syndrome13.4PCNA, MKI67, KRT7, KRT1
15adenoid cystic carcinoma13.4PCNA, MKI67, TP63, KRT7
16adenocarcinoma in situ13.4CEACAM5, CDKN2A, MCM2
17hepatic adenoma13.4PCNA, CTNNB1, KRT7
18inverted papilloma13.4PCNA, CDKN1B, MKI67
19adenosquamous carcinoma13.4CEACAM5, TP63, KRT7
20malignant peripheral nerve sheath tumor13.3S100A6, CDKN2B, CDKN2A
21colonic polyps13.3PCNA, CDKN2A, CCNG1, CTNNB1
22thymic carcinoma13.3BCL2, CEACAM5, TP63, KRT7
23lung giant cell carcinoma13.3PCNA, CDKN2A, MMP2
24superior limbic keratoconjunctivitis13.3MMP1, MMP3
25tubular adenocarcinoma13.3CEACAM5, TP63, CTNNB1, KRT7
26stomach carcinoma13.3CEACAM5, CDKN2A, FAS
27rectum sarcomatoid carcinoma13.3MKI67, HRAS, KRT7, KRT1
28acute myocarditis13.2FASLG, FAS, TNC
29lumbar disc degeneration13.2MMP3, FASLG, FAS
30adenomatoid tumor13.2CEACAM5, MMP2, KRT7
31thyroid medullary carcinoma13.2CEACAM5, MKI67, FASLG, KRT7
32anaplastic plasmacytoma13.2PCNA, MYC, MKI67, TP63
33trichoepithelioma13.2BCL2, CDKN2B, MKI67, KRT7
34bile duct cancer13.2BCL2, CDKN2A, MMP3
35pleomorphic adenoma13.2PCNA, CDKN1B, HRAS, TP63, TNC
36follicular adenoma13.2MKI67, MCM2, CP
37acute lymphoblastic leukemia, childhood13.1CDKN2B, CDKN1B, CDKN2A, CCNA2
38papillary thyroid carcinoma13.1HRAS, TP63, CTNNB1, KRT1
39secondary hyperparathyroidism of renal origin13.1ALB, GHR, CYP27B1
40drug-induced hepatitis13.1ALB, GHR, CP
41unilateral retinoblastoma13.1RB1, MKI67
42emery-dreifuss muscular dystrophy13.1LMNA, LMNB1, MMP2
43lymphoma, diffuse large cell13.1MYC, BCL2, CDKN2B
44anaplastic carcinoma13.0S100A6, TP63, TNFSF10, KRT7
45aggressive digital papillary adenocarcinoma13.0PCNA, CDKN1B, MKI67, CTNNB1
46mucoepidermoid carcinoma13.0PCNA, CEACAM5, CDKN1B, MKI67, TP63, KRT7
47large granular lymphocyte leukemia13.0BCL2, CFLAR, FASLG, FAS
48conjunctivochalasis13.0MMP1, MMP2, MMP3
49hidradenocarcinoma12.9TP53, TP63, KRT7
50myoepithelioma12.9PCNA, TP53, TP63

Graphical network of the top 20 diseases related to actinic keratosis:



Graphical network of diseases related to actinic keratosis

Clinical Features for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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22MalaCards
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MalaCards organs/tissues related to actinic keratosis:

22
Skin, T cells, B cells

Phenotypes for genes affiliated with Actinic Keratosis

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25MGI
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MGI Mouse Phenotypes related to actinic keratosis:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.7TP63
2craniofacial phenotypeMP:000538210.5LMNB1
3liver/biliary system phenotypeMP:000537010.2TP53, GHR, CCNG1
4endocrine/exocrine gland phenotypeMP:00053799.9TP63, GHR, FASLG, CDKN1B, CDKN2B
5hematopoietic system phenotypeMP:00053979.5TLR7, CCNA2, MCM2, CDKN2B, CFLAR, BCL2
6reproductive system phenotypeMP:00053899.5TP63, HRAS, FASLG, CDKN1B, CDKN2B, LMNA
7immune system phenotypeMP:00053878.8CNN2, CYP27B1, TP63, TP53, GHR, MCM2
8renal/urinary system phenotypeMP:00053678.6TLR7, CTNNB1, CYP27B1, TP63, GHR, HRAS
9limbs/digits/tail phenotypeMP:00053718.3CTNNB1, TP63, GHR, FAS, LMNA, RB1
10normal phenotypeMP:00028738.0TNC, TP63, HRAS, ALB, FASLG, MCM2
11digestive/alimentary phenotypeMP:00053817.9CTNNB1, TP63, CCNG1, MCM2, CDKN2A, BCL2
12adipose tissue phenotypeMP:00053757.6TP53, GHR, MCM2, CDKN1B, BCL2, MYC
13mortality/agingMP:00107687.4GHR, TP53, TNFSF10, KRT1, TLR7, DSG2
14behavior/neurological phenotypeMP:00053867.1CTNNB1, TNC, GHR, HRAS, FAS, MCM2
15hearing/vestibular/ear phenotypeMP:00053777.0CTNNB1, TNC, FAS, CDKN1B, BCL2, MYC
16muscle phenotypeMP:00053696.6CTNNB1, TP63, TP53, MCM2, MMP2, CDKN2A
17pigmentation phenotypeMP:00011866.4CP, KRT1, CTNNB1, TP53, FAS, MCM2
18vision/eye phenotypeMP:00053916.4CTNNB1, TP63, TP53, FAS, FASLG, MMP2
19integument phenotypeMP:00107716.2FAS, HRAS, TP53, TP63, CTNNB1, KRT1
20skeleton phenotypeMP:00053906.2CTNNB1, CYP27B1, TNFSF10, TP63, TP53, HRAS
21growth/size phenotypeMP:00053785.9HRAS, GHR, TP53, TP63, CYP27B1, CTNNB1
22cardiovascular system phenotypeMP:00053855.5RB1, CP, CTNNB1, TP63, TP53, GHR
23tumorigenesisMP:00020065.5FAS, CCNG1, HRAS, TP53, TP63, TNFSF10
24nervous system phenotypeMP:00036315.0FASLG, FAS, HRAS, GHR, TP53, TNC
25cellular phenotypeMP:00053844.6FAS, CCNA2, CCNG1, TP53, TP63, TNFSF10
26homeostasis/metabolism phenotypeMP:00053763.5HRAS, GHR, TP53, TP63, TNC, TNFSF10

Publications for genes affiliated with Actinic Keratosis

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35PubMed
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Articles related to actinic keratosis:

(show all 32)
idTitleAuthorsYearAffiliating Genes
1Expression of p53 and p16 in actinic keratosis, bowen oid actinic keratosis and Bowen's disease. (19515076)Bagazgoitia L.... Juarranz A.2010TP53, CDKN2A
2Minichromosome maintenance protein expression accordi ng to the grade of atypism in actinic keratosis. (20847638)Shin J.W.... Cho K.H.2010MCM2
3MYC gene numerical aberrations in actinic keratosis a nd cutaneous squamous cell carcinoma. (19673870)Toll A.... Pujol R.M.2009MYC
4Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations. (19293009)Kaminaka C.... Furukawa F.2009CCNA2
5Expression of cell proliferation and apoptosis bioma rkers in skin spinocellular carcinoma and actinic keratosis (20098848)Dornelas M.T.... Ferreira A.P.2009PCNA
6Expression of P27, Ki67 and P53 in squamous cell carc inoma, actinic keratosis and Bowen disease. (19777788)Talghini S.... Baybordi H.2009TP53, CDKN1B, MKI67
7An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. (19138009)Puizina-IviA8 N.... MiriA8 L.2008BCL2
8Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis. (18331779)Kanellou P.... Spandidos D.A.2008TP53, CDKN2A, CDKN2B
9Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis. (17488404)Nindl I.... Forschner T.2007HRAS, TP53, CDKN2A
10The characteristics of human papillomavirus expression and cell proliferation in actinic keratosis and Bowen's disease of the skin. (16905862)Kvlividze O.... Burkadze G.2006BCL2, PCNA
11Tenascin expression in actinic keratosis. (17083689)Lentini M.... Batolo D.2006TNC
12Tenascin-C patterns and splice variants in actinic keratosis and cutaneous squamous cell carcinoma. (16965426)Dang C.... Nindl I.2006TNC
13Cyclin A and beta-catenin expression in actinic keratosis, Bowen's disease and invasive squamous cell carcinoma of the skin. (16307653)Brasanac D.... Radojevic S.2005CTNNB1, CCNA2
14Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. (15257310)Nilsson K.... Landberg G.2004RB1, CDKN2A
15Expression of p53, bcl-2 and growth hormone receptor in atrophic type of actinic keratosis. (14757281)StanimiroviA8 A.... Belicza M.2004GHR
16Increased Fas ligand expression by T cells and tumour cells in the progression of actinic keratosis to squamous cell carcinoma. (15270871)Satchell A.C.... Halliday G.M.2004FAS, FASLG
17p16INK4a expression in actinic keratosis and Bowen's disease. (14632806)Salama M.E.... Ormsby A.H.2003CDKN2A
18Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (12534602)Tilli C.M.... Neumann H.A.2003LMNA, LMNB1
19Human papillomavirus infection in actinic keratosis and bowen's disease: comparative study with expression of cell-cycle regulatory proteins p21(Waf1/Cip1), p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions. (14562284)Mitsuishi T.... Kawashima M.2003TP53, PCNA, MKI67
20Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type. (12756585)Stanimirovic A.... Belicza M.2003TP53, BCL2, GHR
21S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis. (12652189)Ribe A.... McNutt N.S.2003S100A2, S100A6
22Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16(INK4a) tumor suppressor. (11804749)Mortier L.... DanzAc P.M.2002CDKN2A
23Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget's disease. (12383215)Mai K.T.... Yazdi H.M.2002CEACAM5, KRT7
24Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)Ishida H.... Fukuda M.2001KRT1
25Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation. (11442750)Bachmann F.... Erb P.2001FAS, TNFSF10, CFLAR
26Histopathology of incipient intraepidermal squamous cell carcinoma ('actinic keratosis'). (10607351)Cockerell C.J.2000TP53
27Plasma antioxidant defense in actinic keratosis and basal cell carcinoma. (10568487)Vural P.... SelAsuki D.1999ALB, CP
28Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis. (10362121)Tsukifuji R.... Shinkai H.1999MMP3, MMP2, MMP1
29Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)Krunic A.L.... Clark R.E.1998DSG2
30Evaluation of proliferating cell nuclear antigen as a surrogate end point biomarker in actinic keratosis and adjacent, normal-appearing, and non-sun-exposed human skin samples. (9162299)Einspahr J.... Grogan T.1996PCNA
31Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression. (8594075)Bito T.... Ichihashi M.1995TP53, CCNG1
32Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. (7923098)Nelson M.A.... Bozzo P.O.1994TP53

Expression for genes affiliated with Actinic Keratosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Pathways for genes affiliated with Actinic Keratosis

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41Thomson Reuters, 10EMD Millipore, 36QIAGEN, 38Reactome, 20KEGG, 37R&D Systems, 3Cell Signaling Technology
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Pathways related to actinic keratosis according to GeneDecks:

(show top 50)    (show all 60)
idPathwayScoreTop Affiliating Genes
1Signal transduction_PTEN pathway4110.4PCNA
2Transcription P53 signaling pathway1010.3CDKN2A, TP53
3Signal transduction PTEN pathway1010.2HRAS, PCNA
4DNA damage ATM/ATR regulation of G1/S checkpoint1010.1CCNA2, MYC
5GADD45 Pathway3610.0TP53, CCNG1, CCNA2, PCNA
6Cell adhesion Cell-matrix glycoconjugates109.9CEACAM5, MMP1, MMP3, TNC
7Cell adhesion_Cell-matrix glycoconjugates419.9TNC, MMP3, MMP1, CEACAM5
8Apoptosis389.6FASLG, TNFSF10, DSG2
9Measles209.6TLR7, TNFSF10, TNFRSF10C, FASLG, CDKN1B
10Apoptosis and survival_Caspase cascade419.6FAS, FASLG, LMNB1, LMNA
11Apoptosis and survival Caspase cascade109.6FAS, FASLG, LMNB1, LMNA
12DNA damage_ATM/ATR regulation of G1/S checkpoint419.5TP53, CCNA2, MYC, PCNA
13Apoptosis through Death Receptors369.5BCL2, CFLAR, TP53, TNFRSF10C, TNFSF10
14Development_Thrombopoietin-regulated cell processes419.5HRAS, CCNA2, CDKN1B, MYC
15Development Thrombopoietin-regulated cell processes109.4HRAS, CCNA2, CDKN1B, MYC
16Fas Signaling369.3CFLAR, LMNB1, LMNA, RB1
17Non-small cell lung cancer209.3HRAS, CDKN2A, RB1
18Signal transduction_AKT signaling419.3TP53, FASLG, CDKN1B, MYC, PCNA
19Apoptosis and survival_Apoptotic TNF-family pathways419.3TNFSF10, FAS, FASLG, BCL2
20Signal transduction_JNK pathway419.3TP53, HRAS, FAS, FASLG
21Thyroid cancer209.2MYC, HRAS, TP53, CTNNB1
22Apoptosis and survival Apoptotic TNF-family pathways109.2TNFSF10, FAS, FASLG, BCL2
23Signal transduction JNK pathway109.2TP53, HRAS, FAS, FASLG
24Apoptosis and survival_FAS signaling cascades419.2FAS, FASLG, CFLAR, BCL2, LMNB1, LMNA
25Apoptosis and survival FAS signaling cascades109.2FAS, LMNA, LMNB1, BCL2, CFLAR, FASLG
26Glioblastoma Multiforme369.1TP53, HRAS, CDKN1B, RB1
27Metalloproteases in connective tissue degradation109.1TNC, MMP3, MMP2, MMP1
28Cell Cycle, Mitotic389.1CCNA2, MCM2, CDKN2A, CDKN1B, RB1, PCNA
29Endometrial cancer209.0MYC, HRAS, TP53, CTNNB1
30Cell cycle ESR1 regulation of G1/S transition109.0CCNA2, CDKN1B, MYC, RB1
31Cell cycle_ESR1 regulation of G1/S transition419.0CCNA2, CDKN1B, MYC, RB1
32Inhibition of Ribosome Biogenesis by p14(ARF)368.9RB1, MYC, CDKN2A, TP53
33Apoptosis Signaling Pathways378.9TNFSF10, TP53, FAS, FASLG, BCL2
34Natural killer cell mediated cytotoxicity208.9FASLG, FAS, HRAS, TNFRSF10C, TNFSF10
35Estrogen-mediated S-Phase Entry368.8CCNA2, CDKN1B, MYC, RB1
36G1-S Phase Transition368.8TP53, CCNA2, CDKN2A, CDKN1B, CDKN2B, RB1
37Cyclins and Cell Cycle Regulation368.8TP53, CCNA2, CDKN2A, CDKN1B, CDKN2B, RB1
38Apoptosis208.7TNFSF10, TNFRSF10C, TP53, FAS, FASLG, CFLAR
39Colorectal Cancer Metastasis368.6TLR7, CTNNB1, TP53, MMP2, MMP1, MYC
40Chronic myeloid leukemia208.4TP53, HRAS, CDKN2A, CDKN1B, MYC, RB1
41Prostate cancer208.4CTNNB1, TP53, HRAS, CDKN1B, BCL2, RB1
42Transcription_P53 signaling pathway418.4CTNNB1, TP53, MMP2, CDKN2A, BCL2, RB1
43Small cell lung cancer208.4TP53, CDKN1B, CDKN2B, BCL2, MYC, RB1
44Cell Cycle / Checkpoint Control38.3TP63, TP53, CCNA2, MCM2, CDKN2A, CDKN1B
45Apoptosis and Autophagy38.2TNFSF10, TNFRSF10C, FAS, FASLG, CFLAR, BCL2
46Bladder cancer208.1TP53, HRAS, MMP2, MMP1, CDKN2A, MYC
47Cell cycle208.1TP53, CCNA2, MCM2, CDKN2A, CDKN1B, CDKN2B
48Pancreatic Adenocarcinoma367.5TP53, CCNG1, CCNA2, MMP3, MMP2, MMP1
49Molecular Mechanisms of Cancer367.0CTNNB1, TNFSF10, TP53, HRAS, CDKN2A, CDKN1B
50Pathways in cancer206.7RB1, CTNNB1, TP53, FAS, MMP2, MMP1

Compounds for genes affiliated with Actinic Keratosis

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to actinic keratosis according to GeneDecks:

(show top 50)    (show all 208)
idCompoundScoreTop Affiliating Genes
1h2o232 10.8CCNG1
2roscovitine32 9.7PCNA, CCNA2, TNFSF10, CTNNB1
3ly29400232 9.4CDKN1B, CFLAR, HRAS, CCNA2, FASLG, MMP2
4rapamycin32 42 10.2CCNG1, CCNA2, CFLAR, RB1, HRAS
5hematoxylin32 9.1MMP1, KRT1, KRT7, TP63, MKI67, MMP3
6estradiol32 9 18 9 11.6MKI67, CCNA2, FASLG, CDKN1B, CFLAR, RB1
7dutp32 8.3TNFSF10, FAS, FASLG, MKI67, CFLAR, BCL2
8celecoxib32 42 34 9 18 9 13.0MMP1, MMP3, CTNNB1, TNFSF10, CCNA2, MKI67
9estrogen32 7.9GHR, TP63, TNC, CYP27B1, KRT1, CP
10sb 20358032 42 8.6BCL2, MMP1, MMP2, MMP3, CCNA2, CTNNB1
11camptothecin32 42 9 9 10.6BCL2, CFLAR, CDKN1B, CDKN2A, CCNA2, TP53
12bromodeoxyuridine32 7.5KRT1, CTNNB1, TP63, PCNA, RB1, MYC
13tgf beta132 7.5CDKN2B, CTNNB1, TNC, CCNA2, MMP1, FASLG
14lovastatin32 42 9 9 10.4RB1, CCNA2, HRAS, MMP2, CTNNB1, CDKN1B
15gemcitabine32 34 9 9 10.4CDKN1B, TP53, MMP2, TNFSF10, HRAS, MYC
16progesterone32 42 9 18 9 11.4KRT1, KRT7, CTNNB1, PCNA, RB1, BCL2
17cysteine32 7.4PCNA, LMNB1, S100A2, S100A6, CFLAR, CEACAM5
185-aza-2deoxycytidine32 7.1PCNA, MYC, S100A2, CFLAR, CDKN2B, CDKN2A
19adpribose32 7.1PCNA, RB1, LMNB1, BCL2, FASLG, TNFSF10
20mg 13232 42 8.0PCNA, MYC, BCL2, CFLAR, CDKN1B, CDKN2A
21doxorubicin32 34 9 9 9.9CFLAR, CEACAM5, CDKN1B, MMP1, MKI67, FASLG
22arsenite32 18 7.9CDKN2B, CDKN2A, MMP1, FASLG, FAS, CCNA2
23tamoxifen32 34 9 9 9.7FAS, PCNA, CTNNB1, TNFSF10, GHR, MYC
24depsipeptide32 6.7TNFSF10, TP53, RB1, MYC, BCL2, CFLAR
25methotrexate32 34 42 9 9 10.7PCNA, RB1, CDKN2B, CDKN1B, CDKN2A, MMP1
26resveratrol32 9 18 9 9.7TP53, CDKN1B, CTNNB1, CCNA2, TNFSF10, FAS
27vegf32 6.7PCNA, CP, KRT7, CTNNB1, MYC, BCL2
28cytarabine32 34 9 9 9.7PCNA, RB1, MYC, BCL2, CDKN2B, CDKN1B
29zinc32 18 7.6MKI67, LMNA, RB1, CYP27B1, CCNA2, S100A2
30adriamycin32 6.5RB1, MYC, BCL2, CFLAR, CEACAM5, CTNNB1
31n acetylcysteine32 6.4FASLG, PCNA, CTNNB1, TNFSF10, MMP3, CDKN2A
32etoposide32 42 9 9 9.3PCNA, RB1, LMNB1, MYC, BCL2, CFLAR
33vitamin a32 9 18 9 9.3RB1, ALB, MYC, GHR, MMP1, MMP2
34actinomycin d32 6.3TNFSF10, TNFRSF10C, FAS, TNC, TP53, CCNG1
35thymidine32 18 7.2PCNA, RB1, MYC, CFLAR, MKI67, FASLG
36butyrate32 6.0FASLG, FAS, CCNA2, TP53, TNFSF10, CTNNB1
375fluorouracil32 5.9CDKN2A, MMP2, MKI67, FASLG, FAS, CCNA2
38retinoic acid32 42 18 7.7HRAS, GHR, TNC, TNFSF10, CYP27B1, KRT7
39pd 98,05932 5.7RB1, MYC, BCL2, CFLAR, CDKN2B, CDKN1B
40genistein32 9 18 9 8.5PCNA, BCL2, MYC, RB1, CDKN1B, CDKN2A
41cycloheximide32 5.5CYP27B1, CTNNB1, TNFSF10, TNFRSF10C, TNC, MYC
42dexamethasone32 42 34 9 9 9.5PCNA, FAS, CP, CTNNB1, RB1, MYC
43cisplatin32 34 9 9 8.4CDKN1B, CDKN2A, MKI67, FASLG, FAS, CCNA2
44oligonucleotide32 5.4PCNA, RB1, MYC, BCL2, S100A2, S100A6
45phosphatidylinositol32 5.3CTNNB1, FAS, MMP2, FASLG, TNFSF10, TNFRSF10C
46paclitaxel32 34 9 9 8.2PCNA, RB1, LMNB1, CTNNB1, TNFSF10, MYC
47testosterone32 9 18 9 7.9FASLG, FAS, CCNA2, CCNG1, ALB, GHR
48tyrosine32 4.6RB1, MKI67, FASLG, FAS, CCNA2, CCNG1
49paraffin32 4.3FASLG, FAS, CCNA2, HRAS, GHR, TP53
50serine32 3.6CTNNB1, MKI67, TNC, TP53, GHR, CCNG1

GO Terms for genes affiliated with Actinic Keratosis

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12Gene Ontology
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Cellular components related to actinic keratosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.3MYC, CDKN2A, TP53
2perinuclear region of cytoplasmGO:0484718.1CTNNB1, HRAS, CCNG1, FAS, FASLG, S100A6
3nucleoplasmGO:0056547.3TP63, TP53, CCNA2, MCM2, CDKN2A, CDKN1B
4cytoplasmGO:0057375.4KIN, HRAS, TRIM16, TP53, TP63, CYP27B1
5nucleusGO:0056344.2CCNG1, CCNA2, FAS, FASLG, HRAS, GHR

Biological processes related to actinic keratosis according to GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.1CDKN2A, CDKN1B, CDKN2B
2positive regulation of cell agingGO:09034310.0LMNA, TP53
3positive regulation of cell cycle arrestGO:07115810.0CDKN2A, TP53, CRLF3
4regulation of cyclin-dependent protein kinase activityGO:00007910.0CDKN2B, CDKN1B, CCNA2, CCNG1
5inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
6cellular component disassembly involved in apoptotic processGO:0069219.8LMNA, LMNB1, CTNNB1, DSG2
7cell agingGO:0075699.8TP63, TP53, BCL2
8collagen catabolic processGO:0305749.8MMP3, MMP2, MMP1
9mitotic cell cycle G1/S transition checkpointGO:0315759.6RB1, CDKN2B, HRAS
10extracellular matrix disassemblyGO:0226179.6MMP1, MMP2, MMP3
11positive regulation of mesenchymal cell proliferationGO:0020539.5CTNNB1, TP63, MYC
12release of cytochrome c from mitochondriaGO:0018369.4MYC, BCL2, TP53
13response to growth factor stimulusGO:0708489.4FAS, FASLG, MYC
14induction of apoptosis by intracellular signalsGO:0086299.4TP53, HRAS, BCL2, MYC
15G1 phase of mitotic cell cycleGO:0000809.3CDKN2A, CDKN1B, CDKN2B, RB1
16Ras protein signal transductionGO:0072659.0TP53, HRAS, CCNA2, CDKN2A, RB1
17G1/S transition of mitotic cell cycleGO:0000829.0MCM2, CDKN2A, CDKN1B, BCL2, RB1, PCNA
18induction of apoptosisGO:0069179.0TNFSF10, TP63, FAS, FASLG, CDKN2A, CDKN1B
19response to gamma radiationGO:0103329.0MYC, BCL2, TP53
20negative regulation of cell proliferationGO:0082858.9CTNNB1, CYP27B1, TP53, HRAS, CDKN2A, CDKN1B
21mitotic cell cycleGO:0002788.9CCNA2, MCM2, CDKN2A, CDKN1B, CDKN2B, RB1
22cell cycle checkpointGO:0000758.9TP53, MCM2, CDKN2A, CDKN1B, RB1
23activation of pro-apoptotic gene productsGO:0086338.8TNFSF10, FAS, FASLG, BCL2, MYC
24negative regulation of cell growthGO:0303088.7CRLF3, CYP27B1, TP53, CDKN2A, CDKN1B, BCL2
25neuron apoptotic processGO:0514028.6TP63, TP53, FAS, BCL2, RB1
26activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.6TNFSF10, FAS, FASLG, CDKN2A, CDKN1B, MYC
27negative regulation of apoptotic processGO:0430668.5TP53, ALB, CCNG1, CDKN1B, BCL2, MYC
28virus-host interactionGO:0190488.4KRT7, TP53, MMP1, CFLAR, RB1, KIN
29positive regulation of apoptotic processGO:0430658.4CTNNB1, TNFSF10, TP53, FAS, FASLG
30cell cycle arrestGO:0070508.2TP53, HRAS, CDKN2A, CDKN1B, CDKN2B, MYC
31positive regulation of transcription, DNA-dependentGO:0458937.9CRLF3, CTNNB1, TP63, TP53, TRIM16, CCNA2
32positive regulation of transcription from RNA polymerase II promoterGO:0459447.8CRLF3, CTNNB1, TP63, TP53, HRAS, CDKN2A
33apoptotic processGO:0069157.4LMNA, DSG2, CTNNB1, TNFSF10, TNFRSF10C, TP63

Molecular functions related to actinic keratosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase inhibitor activityGO:0048619.5CDKN2A, CDKN1B, CDKN2B
2transcription factor bindingGO:0081347.8RB1, MYC, BCL2, CDKN2A, TP53, CTNNB1
3protein bindingGO:0055152.9PCNA, CCNG1, ALB, HRAS, GHR, TRIM16

Sources for Actinic Keratosis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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