MCID: ACT008
MIFTS: 54

Actinic Keratosis malady

Skin diseases, Cancer diseases categories
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Summaries for Actinic Keratosis

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Wikipedia:65 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\"; abbreviated as \"AK\") is a... more...

MalaCards based summary: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and basal cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Apoptosis and TP53 network. The compounds eb 1089 and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Actinic Keratosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Actinic Keratosis, Aliases & Descriptions:

Name: Actinic Keratosis 8 10 44 62
Senile Hyperkeratosis 8 62
Sk - Solar Keratosis 8 62
 
Actinic Keratosis 8
Solar Keratosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Related Diseases for Actinic Keratosis

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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.8KRT1
2basal cell carcinoma31.6TP63, CYP27B1
3retinoblastoma30.0CCNA2, CDKN2A, CDKN2B
4melanoma29.8CDKN2B, CDKN2A, GHR, TP63, CYP27B1, CCNA2
5osteosarcoma29.7CYP27B1, CDKN2A, GHR, CCNA2
6breast cancer29.7CYP27B1, TP63, CCNA2, CDKN2A
7leukemia29.4CYP27B1, CCNA2, CDKN2B, GHR, CDKN2A
8blindness10.6
9leukoplakia10.4KRT1
10keratoacanthoma10.4
11psoriasis10.4
12seborrheic keratosis10.4
13secondary hyperparathyroidism of renal origin10.3CYP27B1, GHR
14superficial basal cell carcinoma10.3
15albinism10.3
16osteoporosis, postmenopausal10.3CYP27B1, GHR
17autoimmune thyroiditis10.2CYP27B1, TP63
18oral leukoplakia10.2TP63, KRT1
19meningioma10.2CDKN2B, KRT1
20neuroendocrine carcinoma10.2KRT1, TP63
21phyllode tumor10.2CCNA2, TP63
22skin benign neoplasm10.2KRT1, TP63
23papillary thyroid carcinoma10.1TP63, KRT1
24hypertension10.1
25renal cell carcinoma10.1
26severe combined immunodeficiency10.1
27lichen planus10.1
28rosacea10.1
29oculocutaneous albinism10.1
30infiltrative basal cell carcinoma10.1
31merkel cell carcinoma10.1
32amyloidosis10.1
33cellulitis10.1
34cheilitis10.1
35conjunctivitis10.1
36dermatitis10.1
37lupus erythematosus10.1
38meningitis10.1
39actinic cheilitis10.1
40cheilitis glandularis10.1
41erosive pustular dermatosis of the scalp10.1
42discoid lupus erythematosus10.1
43transitional cell carcinoma10.1CDKN2B, TP63
44cervical squamous cell carcinoma10.1CDKN2A, TP63
45pituitary adenoma10.1GHR, CDKN2B
46anaplastic oligodendroglioma10.1CDKN2B, CDKN2A
47malignant peripheral nerve sheath tumor10.0CDKN2A, CDKN2B
48colon adenocarcinoma10.0CYP27B1, CCNA2
49leukemia, acute lymphoblastic 310.0CDKN2A, CDKN2B
50oligodendroglioma10.0CDKN2B, CDKN2A

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Symptoms for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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MalaCards organs/tissues related to Actinic Keratosis:

32
Skin, Kidney, Testes, T cells

Animal Models for Actinic Keratosis or affiliated genes

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Publications for Actinic Keratosis

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Articles related to Actinic Keratosis:

(show top 50)    (show all 425)
idTitleAuthorsYear
1
Efficacy of imiquimod 3.75% from Lmax according to the number of actinic keratosis lesions. (25351284)
2014
2
Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis. (25349467)
2014
3
Temperature-modulated photodynamic therapy for the treatment of actinic keratosis on the extremities: a pilot study. (25207759)
2014
4
Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer. (24332494)
2014
5
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
6
Current issues in the management of actinic keratosis. (23228304)
2013
7
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
8
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
9
Pharmacotherapeutic management of actinic keratosis: focus on newer topical agents. (23640424)
2013
10
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
11
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
12
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
13
Monitoring blood volume and saturation using superficial fibre optic reflectance spectroscopy during PDT of actinic keratosis. (21842485)
2011
14
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
15
Actinic keratosis: facts and controversies. (20541675)
2010
16
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
17
Merkel cell carcinoma in situ associated with actinic keratosis: fortuitous or serendipitous? (20456542)
2010
18
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. (19878034)
2010
19
Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis. (19926165)
2010
20
Current and emerging treatment strategies for the treatment of actinic keratosis. (21437066)
2010
21
Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma. (21091787)
2010
22
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
23
A pilot study to assess the efficacy of photodynamic therapy for Japanese patients with actinic keratosis in relation to lesion size and histological severity. (19152514)
2009
24
Dermacase. Actinic keratosis. (18474700)
2008
25
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
26
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
27
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
28
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
29
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
30
Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. (16243131)
2005
31
Long-term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream. (15996416)
2005
32
The use of topical imiquimod for the treatment of actinic keratosis: a status report. (16315560)
2005
33
Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. (15389189)
2004
34
Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. (15257310)
2004
35
p16INK4a expression in actinic keratosis and Bowen's disease. (14632806)
2003
36
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
37
Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis. (12271300)
2002
38
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
39
Prevalence of solar damage and actinic keratosis in a Merseyside population. (11251601)
2001
40
Proliferative actinic keratosis: three representative cases. (10632689)
2000
41
Invasive cutaneous squamous cell carcinoma associated with actinic keratosis: a case with orbital invasion and meningeal infiltration. (10469120)
1999
42
Plasma antioxidant defense in actinic keratosis and basal cell carcinoma. (10568487)
1999
43
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. (9568428)
1998
44
Evaluation of proliferating cell nuclear antigen as a surrogate end point biomarker in actinic keratosis and adjacent, normal-appearing, and non-sun-exposed human skin samples. (9162299)
1996
45
Effect of a low-fat diet on the incidence of actinic keratosis. (8145782)
1994
46
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
47
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip. (6946379)
1981
48
DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis. (686819)
1978
49
Actinic keratosis and telangiectasia. (5060883)
1972
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2CDKN2A, TP63
2
Show member pathways
9.2TP63, CDKN2A
39.1CDKN2A, CDKN2B
4
Show member pathways
8.6CDKN2A, CCNA2, TP63
5
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
6
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
7
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
8
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
9
Show member pathways
8.5CDKN2B, CDKN2A, CCNA2
10
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
8.5CDKN2B, CDKN2A, CCNA2
11
Show member pathways
Cell cycle37
8.5CCNA2, CDKN2A, CDKN2B
128.5CDKN2B, CDKN2A, CCNA2

Compounds for genes affiliated with Actinic Keratosis

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Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1eb 108944 6110.8CCNA2, CYP27B1
2p003449.5CDKN2B, GHR, TP63
3dihydrofolate449.5CDKN2B, CCNA2
4sodium bisulfite449.5CDKN2B, CDKN2A
55-methylcytosine44 2410.5CDKN2A, CDKN2B
65-methylthioadenosine449.5CDKN2B, CDKN2A
7isoleucine449.4GHR, KRT1
8o6-methylguanine449.4CDKN2B, CDKN2A
9hpvs449.4CDKN2A, CCNA2
10olomoucine44 1110.4CCNA2, CDKN2A
11hmba449.4CDKN2A, CCNA2
12estradiol44 24 1111.3GHR, CCNA2, CYP27B1
13bromodeoxyuridine449.3KRT1, CCNA2, TP63
14depsipeptide449.2CDKN2A, CCNA2
15chloramphenicol44 2 50 1112.2CDKN2A, GHR, CYP27B1
16roscovitine449.2CCNA2, CDKN2A
175-aza-2deoxycytidine449.2CDKN2B, CDKN2A, CYP27B1
18histidine449.1CDKN2A, GHR, TP63
19hematoxylin449.1CDKN2A, KRT1, TP63
20thymidine44 2410.1TP63, CCNA2, GHR
21selenium44 2410.0CDKN2A, CCNA2
22mg 13244 6110.0CCNA2, GHR, CDKN2A
23lysine448.9CYP27B1, TP63, CCNA2, KRT1
24zinc44 249.9CYP27B1, CCNA2, GHR, KRT1
25cytarabine44 50 1110.9CCNA2, CDKN2A, CDKN2B
26arsenite44 249.9CCNA2, CDKN2A, CDKN2B
27genistein44 28 61 2 24 1113.9CYP27B1, CCNA2, CDKN2A
28methotrexate50 44 1110.9CCNA2, CDKN2A, CDKN2B
29doxorubicin44 50 1110.8TP63, CCNA2, CDKN2A
30dopamine44 28 24 1111.7CDKN2A, GHR, CCNA2
31flavopiridol44 119.7CDKN2A, CCNA2
32cyclic amp44 249.7CYP27B1, CCNA2, GHR, CDKN2A
33cycloheximide448.7CYP27B1, CCNA2, GHR, CDKN2A
34oligonucleotide448.6CYP27B1, CCNA2, GHR, CDKN2A
35oxygen44 249.6CYP27B1, CCNA2, GHR, CDKN2A
36cisplatin44 50 61 1111.6CDKN2A, CCNA2, TP63
37glucose448.6CYP27B1, CCNA2, GHR, CDKN2A
38aspartate448.5CCNA2, GHR, KRT1, CDKN2A
39lipid448.4CDKN2A, KRT1, CCNA2, CYP27B1
40threonine448.4CDKN2B, CDKN2A, KRT1, CCNA2
41progesterone44 28 61 24 1112.1TP63, CCNA2, GHR, KRT1, CDKN2A
42arginine448.1TP63, CCNA2, GHR, KRT1, CDKN2A
43tyrosine448.0CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2B
44calcium44 50 24 1111.0CYP27B1, TP63, CCNA2, KRT1, CDKN2A
45serine448.0CDKN2B, CDKN2A, KRT1, GHR, CCNA2
46paraffin447.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
47testosterone44 61 24 1110.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
48steroid447.7CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A
49estrogen447.2CDKN2B, CYP27B1, TP63, CCNA2, GHR, KRT1
50retinoic acid44 248.2CYP27B1, TP63, CCNA2, GHR, KRT1, CDKN2A

GO Terms for genes affiliated with Actinic Keratosis

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Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CCNA2, CDKN2B
2negative regulation of phosphorylationGO:0423269.3CDKN2B, CDKN2A
3regulation of G2/M transition of mitotic cell cycleGO:0103899.2CDKN2A, CCNA2
4response to estradiolGO:0323559.1GHR, CCNA2
5Ras protein signal transductionGO:0072658.9CCNA2, CDKN2A
6negative regulation of cell proliferationGO:0082858.9CYP27B1, CDKN2A, CDKN2B
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.7CDKN2B, CDKN2A, TP63
8mitotic cell cycleGO:0002788.6CDKN2B, CDKN2A, CCNA2
9positive regulation of transcription, DNA-templatedGO:0458938.6CDKN2A, CCNA2, TP63

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.0CDKN2B, CDKN2A
2p53 bindingGO:0020398.9TP63, CDKN2A
3protein kinase bindingGO:0199018.1CDKN2B, CDKN2A, GHR, CCNA2
4protein bindingGO:0055157.1CDKN2B, CDKN2A, KRT1, GHR, CCNA2, TP63

Products for genes affiliated with Actinic Keratosis

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  • Antibodies
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Sources for Actinic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet