MCID: ACT008
MIFTS: 53

Actinic Keratosis malady

Skin diseases category

Summaries for Actinic Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Actinic keratosis (also called \"solar keratosis\" and \"senile keratosis\") is a premalignant condition... more...

MalaCards: Actinic Keratosis, also known as senile hyperkeratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is CYP27B1 (cytochrome P450, family 27, subfamily B, polypeptide 1), and among its related pathways are Cell Cycle and Cell cycle Transition and termination of DNA replacation. The compounds estradiol and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Actinic Keratosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

actinic keratosis 8 10 44 60
senile hyperkeratosis 8
sk - solar keratosis 8
actinic keratosis 8
solar keratosis 8


Related Diseases for Actinic Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis32.0KRT1
2squamous cell carcinoma31.4CCNA2, TP63, KRT1, HRAS, MCM2, CYP27B1
3basal cell carcinoma31.2S100A2, CYP27B1, TP63
4melanoma30.7TNFRSF10C, S100A6, S100A2, CCNG1, CCNA2, GHR
5skin melanoma30.6CDKN2B
6keratoacanthoma30.4PCNA
7retinoblastoma30.3CCNA2, CCNG1, CDKN2A, CDKN2B, PCNA, HRAS
8breast cancer30.2CCNA2, CCNG1, S100A6, PCNA, CYP27B1, MCM2
9lichen planus30.1KRT1
10osteosarcoma30.1CCNA2, CCNG1, S100A6, GHR, CDKN2A, CYP27B1
11skin squamous cell carcinoma10.7
12in situ carcinoma10.5
13skin disease10.4
14psoriasis10.3
15seborrheic keratosis10.3
16scalp dermatosis10.2
17superficial basal cell carcinoma10.2
18skin carcinoma in situ10.2
19rosacea10.1
20cellulitis10.1
21infiltrative basal cell carcinoma10.1
22merkel cell carcinoma10.1
23amyloidosis10.1
24cheilitis10.1
25conjunctivitis10.1
26dermatitis10.1
27hypertension10.1
28lupus erythematosus10.1
29meningitis10.1
30renal cell carcinoma10.1
31severe combined immunodeficiency10.1
32albinism10.1
33actinic cheilitis10.1
34pancreatitis10.0HRAS
35cholesteatoma10.0S100A6
36myelodysplastic syndromes10.0CDKN2B
37neurofibromatosis10.0HRAS
38thyroid cancer10.0HRAS
39gastrointestinal stromal tumor10.0PCNA
40leukoplakia10.0KRT1, PCNA
41cervical intraepithelial neoplasia10.0CDKN2A, CCNG1
42cervical squamous cell carcinoma10.0TP63, CDKN2A
43spitz nevus10.0HRAS
44oral leukoplakia10.0PCNA, KRT1, TP63
45esophageal cancer10.0CDKN2A
46smooth muscle tumor10.0PCNA, CCNA2
47adult syndrome10.0TP63
48cervical adenocarcinoma10.0CDKN2A
49colon adenocarcinoma10.0CCNA2, CYP27B1, HRAS
50pituitary adenoma10.0PCNA, CDKN2B, GHR

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to actinic keratosis

Clinical Features for Actinic Keratosis

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Drugs & Therapeutics for Actinic Keratosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Actinic Keratosis

Drug clinical trials:

Search ClinicalTrials for Actinic Keratosis

Search NIH Clinical Center for Actinic Keratosis

Search CenterWatch for Actinic Keratosis

Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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32MalaCards
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MalaCards organs/tissues related to Actinic Keratosis:

32
Skin, Kidney, Testes, T cells

Animal Models for Actinic Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Actinic Keratosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1GHR, CDKN2A, CDKN2B, CYP27B1, HRAS
2MP:001077110.1CDKN2A, CDKN2B, CYP27B1, HRAS, KRT1
3MP:00030129.9CDKN2A, CDKN2B, PCNA, HRAS, KRT1, CNN2
4MP:00020069.7CCNG1, CDKN2A, CDKN2B, MCM2, HRAS, TP63
5MP:00053979.6CCNA2, CRLF3, GHR, CNN2, CDKN2A, CDKN2B
6MP:00053849.6TP63, CCNA2, CCNG1, DSG2, CNN2, CDKN2A
7MP:00107689.4CDKN2A, DSG2, GHR, CCNG1, CCNA2, CDKN2B
8MP:00053879.3CCNA2, GHR, CNN2, CDKN2A, CDKN2B, PCNA

Publications for Actinic Keratosis

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50PubMed
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Articles related to Actinic Keratosis:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer. (24332494)
2014
2
Increased expression of enhancer of Zeste Homolog 2 (EZH2) differentiates squamous cell carcinoma from normal skin and actinic keratosis. (24413452)
2014
3
Management of actinic keratosis. (23828668)
2013
4
Actinic keratosis in the en-face and slice imaging mode of high-definition optical coherence tomography and comparison with histology. (22861068)
2013
5
Response to photodynamic therapy for pustular dermatosis of the scalp and hypertrophic actinic keratosis. (23582300)
2013
6
The effect of ultraviolet radiation on the transforming growth factor beta 1/Smads pathway and p53 in actinic keratosis and normal skin. (23632819)
2013
7
Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis. (23252768)
2013
8
Clues for differentiating discoid lupus erythematosus from actinic keratosis. (23768308)
2013
9
Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. (23228301)
2013
10
Non-adherence to topical treatments for actinic keratosis. (24379656)
2013
11
Reduced P53 Staining in Actinic Keratosis is Associated with Squamous Cell Carcinoma: A Preliminary Study. (23919015)
2013
12
Clinical outcome and cyclo-oxygenase-2 expression in five dogs with solar dermatitis/actinic keratosis treated with firocoxib. (24128166)
2013
13
Expression of metallothioneins in cutaneous squamous cell carcinoma and actinic keratosis. (22407324)
2012
14
Expression of gelatinases (MMP-2, MMP-9) and gelatinase activator (MMP-14) in actinic keratosis and in in situ and invasive squamous cell carcinoma. (22534634)
2012
15
Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications. (21644496)
2011
16
Actinic keratosis: facts and controversies. (20541675)
2010
17
An economic evaluation of topical treatments for actinic keratosis. (19421918)
2009
18
The current options in the management of actinic keratosis. (19755948)
2009
19
Long-term Follow up of Diclofenac Sodium 3% in 2.5% Hyaluronic Acid Gel for Actinic Keratosis: One-year Evaluation. (20729966)
2009
20
Sunlight (actinic) keratosis: an update. (20812516)
2009
21
Clinicopathological study of 21 cases of eyelid actinic keratosis. (18633577)
2009
22
Oral and maxillofacial pathology case of the month. Actinic keratosis. (19472552)
2009
23
Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations. (19293009)
2009
24
Cytological diagnosis of basal cell carcinoma and actinic keratosis, using Papanicolaou and May-Grunwald-Giemsa stained cutaneous tissue smear. (18513288)
2008
25
Photodynamic therapy in the treatment of actinic keratosis. (18221454)
2008
26
Crossroads between actinic keratosis and squamous cell carcinoma, and novel pharmacological issues. (18086582)
2008
27
Actinic keratosis associated with squamous and basal cell carcinomas: an evaluation of neoplastic progression by a standardized AgNOR analysis. (18502723)
2008
28
Pathology and pathobiology of actinic (solar) keratosis - an update. (18067626)
2007
29
Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis. (17501954)
2007
30
The nature of solar (actinic) keratosis. (17223905)
2007
31
Management of field change in actinic keratosis. (18067627)
2007
32
Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis. (17488404)
2007
33
Dermoscopy of facial nonpigmented actinic keratosis. (17034524)
2006
34
Important factors for pain during photodynamic therapy for actinic keratosis. (16955183)
2006
35
Imiquimod for actinic keratosis: systematic review and meta-analysis. (16557235)
2006
36
How to treat actinic keratosis on hair-bearing skin? (17128654)
2006
37
Serum lipid fractions, nitric oxide and plasma endothelin-1 levels in actinic keratosis. (15663522)
2005
38
Quantifying actinic keratosis: assessing the evidence. (15186192)
2004
39
Awareness of, knowledge of and attitudes to nonmelanoma skin cancer (NMSC) and actinic keratosis (AK) among physicians. (15357741)
2004
40
Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type. (12756585)
2003
41
Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget's disease. (12383215)
2002
42
Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. (12353677)
2002
43
Prevalence of solar damage and actinic keratosis in a Merseyside population. (11251601)
2001
44
Testing your diagnostic skills (#53). Case 1: Cheilitis glandularis apostematosa. Actinic keratosis (cheilitis). (11545062)
2001
45
Selective inflammatory effect of systemic fluorouracil in actinic keratosis. (10431671)
1999
46
The actinic keratosis. A perspective and update. (9391557)
1997
47
Hypertrophic actinic keratosis. (7142459)
1982
48
Cutaneous vitamin A levels in seborrheic keratosis, actinic keratosis, and basal cell carcinoma. (6454396)
1981
49
DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis. (686819)
1978
50
Actinic keratosis and telangiectasia. (5060883)
1972

Genetic Variations for Actinic Keratosis

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Expression for genes affiliated with Actinic Keratosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Keratosis

Search GEO for disease gene expression data for Actinic Keratosis.

Pathways for genes affiliated with Actinic Keratosis

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Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Actinic Keratosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MCM2
210.3MCM2
3
Hide members
10.2CDKN2B, CDKN2A, CCNA2
410.2CDKN2A, PCNA, HRAS
510.2PCNA, CCNG1, CCNA2
610.1CCNA2, CDKN2A, CDKN2B, HRAS
7
Cell cycle Cell cycle (generic schema)
Hide members
10.1PCNA, CDKN2B, CDKN2A, CCNA2
810.1TP63, HRAS, CDKN2A, CCNG1
910.1CDKN2A, CDKN2B, PCNA, HRAS
10
Hide members
10.1HRAS, CDKN2B, CCNG1, CCNA2
11
Hide members
10.0CCNA2, CDKN2A, PCNA, MCM2
12
Hide members
10.0TP63, MCM2, PCNA, CDKN2A, CCNA2
13
Hide members
9.9CCNA2, CDKN2A, CDKN2B, PCNA, MCM2
14
Hide members
9.9LMNB1, MCM2, PCNA, DSG2, CCNA2
159.9TP63, PCNA, TNFRSF10C, S100A2, CCNG1

Compounds for genes affiliated with Actinic Keratosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Actinic Keratosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.7CCNA2, GHR
2tachyplesin i4410.6PCNA, CDKN2A
3olomoucine44 1111.6PCNA, CDKN2A, CCNA2
4eb 108944 5911.6CYP27B1, PCNA, CCNA2
5o6-methylguanine4410.6CDKN2A, PCNA, CDKN2B
6iudr4410.5PCNA, CCNA2
7hematoxylin4410.5CDKN2A, PCNA, KRT1, TP63
8roscovitine4410.5PCNA, CDKN2A, CCNA2
9cytarabine44 49 1112.5CDKN2B, CDKN2A, PCNA, CCNA2
10mg 13244 5911.5CCNA2, GHR, CDKN2A, PCNA
11bromodeoxyuridine4410.4PCNA, TP63, KRT1, HRAS, CCNA2
12azathioprine44 49 2 1113.4S100A6, PCNA, CDKN2B, CDKN2A
13rpa 24410.4PCNA, CDKN2A
14arsenite44 2411.4CDKN2A, CDKN2B, PCNA, CCNA2
15paclitaxel44 49 1112.4LMNB1, CCNA2, TNFRSF10C, CDKN2A, HRAS
16methotrexate44 49 1112.4PCNA, CDKN2B, CDKN2A, CCNA2
175fluorouracil4410.3TNFRSF10C, CDKN2A, PCNA, CCNA2
18genistein44 28 59 2 11 2415.3HRAS, CYP27B1, PCNA, CDKN2A, CCNA2
19etoposide44 49 59 1113.3S100A2, TNFRSF10C, PCNA, CCNA2, LMNB1
20silver4410.3CDKN2A, PCNA, S100A6
21lysine4410.3CYP27B1, KRT1, TP63, CCNA2, S100A6
22aspartate4410.3HRAS, KRT1, PCNA, CCNA2, CDKN2A, GHR
23thymidine44 2411.3CCNA2, GHR, HRAS, PCNA, TP63
245-aza-2deoxycytidine4410.3TNFRSF10C, S100A2, CDKN2A, CDKN2B, PCNA, CYP27B1
25hpvs4410.3CCNA2, CDKN2A
26adpribose4410.3PCNA, CCNA2, LMNB1
27cisplatin44 49 59 1113.3CCNG1, CCNA2, PCNA, TP63, CDKN2A, HRAS
28doxorubicin44 49 1112.3HRAS, CCNA2, CCNG1, TNFRSF10C, TP63, CDKN2A
29cyclic amp44 2411.3GHR, CDKN2A, CCNA2, HRAS, CYP27B1
30cycloheximide4410.3TNFRSF10C, CCNA2, CYP27B1, CDKN2A, GHR
31glucose4410.3HRAS, CYP27B1, CDKN2A, CCNG1
32arginine4410.2TP63, GHR, PCNA, HRAS, CDKN2A, CCNA2
33gemcitabine44 49 1112.2CCNA2, HRAS, PCNA
34h2o24410.2PCNA, HRAS, CCNA2, CDKN2A, S100A2, CCNG1
35zinc44 2411.2S100A2, GHR, CYP27B1, HRAS, KRT1, S100A6
36hydroxyurea44 49 1112.2CDKN2A, PCNA, CCNA2
37threonine4410.2CDKN2B, HRAS, MCM2, CDKN2A, CCNG1, CCNA2
38progesterone44 59 28 11 2414.1HRAS, CDKN2A, GHR, S100A6, CCNA2, KRT1
39steroid4410.1HRAS, CCNG1, S100A6, CYP27B1, GHR, CDKN2A
40oxygen44 2411.1CDKN2A, GHR, CCNA2, CYP27B1, HRAS, COX7C
41oligonucleotide4410.1CYP27B1, CDKN2A, PCNA, CCNA2, S100A2, S100A6
42lovastatin44 49 59 28 1114.1CCNA2, CDKN2A, HRAS
43cysteine4410.1HRAS, CDKN2A, LMNB1, GHR, PCNA, S100A2
44testosterone44 59 11 2413.0CDKN2A, CCNG1, PCNA, CYP27B1, CCNA2, GHR
45serine4410.0MCM2, CDKN2B, HRAS, KRT1, GHR, CCNG1
46retinoic acid44 2411.0CYP27B1, TP63, CDKN2A, KRT1, HRAS, PCNA
47paraffin449.9CCNA2, HRAS, TP63, KRT1, MCM2, CYP27B1
48p003449.9TP63, CDKN2B, GHR
49tyrosine449.9KRT1, LMNB1, CYP27B1, CDKN2B, DSG2, GHR
50calcium44 49 11 2412.9CYP27B1, HRAS, DSG2, CCNA2, S100A2, CCNG1

GO Terms for genes affiliated with Actinic Keratosis

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16Gene Ontology
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Cellular components related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.9TP63, LMNB1, MCM2, PCNA, CDKN2A, CCNA2

Biological processes related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.3CDKN2B, CCNG1
2positive regulation of cell cycle arrestGO:07115810.3CDKN2A, CRLF3
3mitotic G2 DNA damage checkpointGO:00709510.2CCNA2, CCNG1
4mitotic cell cycleGO:00027810.0MCM2, PCNA, CDKN2B, CDKN2A, CCNA2
5Ras protein signal transductionGO:0072659.9HRAS, CDKN2A, CCNA2

Molecular functions related to Actinic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2B, CDKN2A
2protein kinase bindingGO:0199019.8CCNA2, GHR, CDKN2A, CDKN2B
3protein bindingGO:0055159.2CCNG1, S100A2, S100A6, GHR, CDKN2A, CDKN2B

Products for genes affiliated with Actinic Keratosis

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  • Antibodies
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Sources for Actinic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet