MCID: ACT164
MIFTS: 34

Actinic Prurigo malady

Genetic diseases, Skin diseases, Rare diseases categories

Aliases & Classifications for Actinic Prurigo

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Actinic Prurigo, Aliases & Descriptions:

Name: Actinic Prurigo 47 60
Hereditary Polymorphous Light Eruption of American Indians 47
Familial Polymorphous Light Eruption of American Indians 47
 
Hutchinson Summer Prurigo 47
Hydroa Aestivale 47
Hydroa Estivale 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Orphanet: 47 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

47
actinic prurigo:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood


External Ids:

Orphanet47 330061
ICD10 via Orphanet26 L56.4

Summaries for Actinic Prurigo

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Wikipedia:63 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards based summary: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to porphyria and congenital porphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and Epstein-Barr virus infection. The compounds nickel and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Related Diseases for Actinic Prurigo

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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria10.5
2congenital porphyria10.5
3sialadenitis10.4ITGAL
4leishmaniasis10.3IL13
5hypertrichosis10.3
6hydroa vacciniforme10.3
7cheilitis10.3
8leprosy10.2HLA-DRB1
9skin disease10.2HLA-DRB1
10spondylarthropathy10.2TNF, ITGAL
11cutaneous lupus erythematosus10.2
12allergic contact dermatitis10.2
13conjunctivitis10.2
14contact dermatitis10.2
15dermatitis10.2
16lupus erythematosus10.2
17urticaria10.2
18solar urticaria10.2
19pulmonary sarcoidosis10.2TNF, ITGAL
20asthma10.1TNF, IL13
21monocytic leukemia10.1ITGAL, TNF
22bullous pemphigoid10.1IL13, ITGAL
23colitis10.0IL13, TNF
24allergic asthma10.0ITGAL, IL13
25malaria10.0TNF, HLA-DRB1
26pulmonary disease, chronic obstructive10.0IL13, TNF
27juvenile rheumatoid arthritis10.0HLA-DRB1, TNF
28viral hepatitis10.0ITGAL, HLA-DRB1
29connective tissue disease10.0TNF, HLA-DRB1
30primary biliary cirrhosis10.0HLA-DRB1, ITGAL
31hypersensitivity reaction type ii disease10.0HLA-DRB1, TNF
32hepatitis c10.0TNF, HLA-DRB1
33atopic dermatitis10.0IL13, TNF
34pneumonia9.9TNF, IL13
35cork-handlers' disease9.9TNF, ITGAL, IL13
36inflammatory bowel disease9.9TNF, ITGAL, IL13
37systemic scleroderma9.9HLA-DRB1, IL13
38lymphoma, non-hodgkin9.9HLA-DRB1, ITGAL
39tuberculosis9.8ITGAL, TNF, HLA-DRB1
40systemic lupus erythematosus9.8ITGAL, HLA-DRB1, TNF
41psoriatic arthritis9.8HLA-DRB1, IL13, TNF
42sarcoidosis 19.8IL13, TNF, HLA-DRB1
43graves' disease9.8IL13, HLA-DRB1, ITGAL
44ulcerative colitis9.8IL13, TNF, HLA-DRB1
45arthritis9.8IL13, HLA-DRB1, TNF
46hepatitis b9.7HLA-DRB1, ITGAL
47leukemia9.7TNF, HLA-DRB1, ITGAL
48graft-versus-host disease, protection against9.6IL13, ITGAL, TNF, HLA-DRB1
49psoriasis9.6TNF, HLA-DRB1, ITGAL, IL13
50multiple sclerosis, disease progression, modifier of9.6ITGAL, IL13, TNF, HLA-DRB1

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Drug clinical trials:

Search ClinicalTrials for Actinic Prurigo

Search NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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MalaCards organs/tissues related to Actinic Prurigo:

31
Skin, Testes

Animal Models for Actinic Prurigo or affiliated genes

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Publications for Actinic Prurigo

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Articles related to Actinic Prurigo:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Allergic contact dermatitis to Parthenium hysterophorus mimicking actinic prurigo. (25566915)
2015
2
Actinic prurigo of the lip: Two case reports. (25133153)
2014
3
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
4
Actinic prurigo: a case-control study of risk factors. (23968196)
2013
5
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
6
Case for diagnosis. Actinic prurigo. (21152806)
2010
7
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
8
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
9
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
10
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
11
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
12
Actinic prurigo in an Albanian girl. (16445427)
2006
13
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
14
Actinic prurigo. (16101881)
2005
15
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
16
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
17
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. (12193899)
2002
18
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
19
Long-term thalidomide for actinic prurigo. (11903163)
2001
20
Effectors of inflammation in actinic prurigo. (11369907)
2001
21
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
22
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. (11722460)
2001
23
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. (11124306)
2000
24
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
25
A case of actinic prurigo in Thailand. (10692819)
2000
26
The clinical features and management of actinic prurigo: a retrospective study. (10540941)
1999
27
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
28
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
29
Actinic prurigo: limited effect of PUVA. (9217842)
1997
30
Managing PLE and actinic prurigo. (9156494)
1997
31
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
32
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
33
Actinic prurigo: an update. (7657433)
1995
34
Actinic prurigo. (7607801)
1995
35
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
36
Histopathology of actinic prurigo. (8214390)
1993
37
Actinic prurigo: clinical features and prognosis. (1583166)
1992
38
Actinic prurigo. (1587676)
1992
39
HLA typing in actinic prurigo. (1597562)
1992
40
Treatment of actinic prurigo with intermittent short-course topical 0.05% clobetasol 17-propionate. A preliminary report. (2396838)
1990
41
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
45
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Pathways related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DRB1, IL13
29.3ITGAL, HLA-DRB1
39.3HLA-DRB1, ITGAL
49.3HLA-DRB1, ITGAL
59.1IL13, TNF
6
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.1IL13, TNF
79.1IL13, TNF
89.1ITGAL, TNF
9
Show member pathways
9.1ITGAL, TNF
10
Show member pathways
Immune response CD16 signaling in NK cells58
9.1TNF, ITGAL
119.0TNF, HLA-DRB1
129.0TNF, HLA-DRB1
13
Show member pathways
8.6IL13, ITGAL, TNF
14
Show member pathways
8.6IL13, ITGAL, TNF
15
Show member pathways
8.6TNF, ITGAL, IL13
16
Show member pathways
8.5IL13, TNF, HLA-DRB1
17
Show member pathways
8.5IL13, TNF, HLA-DRB1
188.5IL13, TNF, HLA-DRB1
198.5HLA-DRB1, TNF, ITGAL
208.5HLA-DRB1, TNF, ITGAL
21
Show member pathways
8.0IL13, ITGAL, TNF, HLA-DRB1

Compounds for genes affiliated with Actinic Prurigo

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Compounds related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1nickel43 2410.8ITGAL, IL13
2glatiramer acetate43 1210.8IL13, HLA-DRB1
3theophylline43 28 24 1212.7IL13, ITGAL
4alpha tocopherol439.6IL13, ITGAL
5efalizumab43 1210.6ITGAL, TNF
6mip 1alpha439.6TNF, IL13
7il-12439.6IL13, TNF
8indoleamine439.5IL13, TNF
9staurosporin439.5ITGAL, TNF
10groalpha439.5TNF, IL13
11leflunomide43 49 1211.5TNF, IL13
12gm-csf43 2810.5IL13, TNF
13budesonide43 49 1211.5TNF, IL13
14fluticasone propionate43 49 59 1212.5IL13, TNF
15rolipram43 59 2811.5IL13, TNF
16il 10439.5IL13, TNF
17tarc439.5TNF, IL13
18n-formylmethionyl-leucylphenylalanine439.5ITGAL, TNF
19pentoxifylline43 1210.5IL13, TNF
20ccl343 2810.5IL13, TNF
21gold sodium thiomalate439.5TNF, HLA-DRB1
22rituximab43 49 1211.4IL13, TNF
23cyclophosphamide43 49 1211.4IL13, ITGAL
24thalidomide43 49 59 1212.4IL13, TNF
25chloroquine43 2 49 28 1213.4ITGAL, TNF
26sp 60012543 5910.3IL13, TNF
27hyaluronic acid43 2410.3IL13, ITGAL
28allergens439.3IL13, ITGAL, HLA-DRB1
29hydrocortisone43 2 59 1212.2IL13, TNF
30tgf beta1439.2IL13, TNF
31simvastatin43 49 59 28 24 1214.1TNF, ITGAL
32mannose439.1IL13, ITGAL
33leukotriene b443 59 2411.1IL13, ITGAL, TNF
34prednisolone43 28 1211.1TNF, ITGAL, IL13
35endotoxin439.1IL13, ITGAL, TNF
36ionomycin439.1IL13, ITGAL, TNF
37fmlp439.1TNF, ITGAL, IL13
38glutamate439.0IL13, ITGAL, HLA-DRB1
39tacrolimus43 49 1211.0IL13, ITGAL, TNF
40calcitriol43 59 24 1212.0TNF, ITGAL, IL13
41rantes439.0IL13, ITGAL, TNF
42alanine439.0HLA-DRB1, ITGAL, IL13
43actinomycin d439.0TNF, ITGAL, IL13
44cyclosporin a43 28 5911.0TNF, ITGAL, IL13
45pge2439.0IL13, ITGAL, TNF
46cycloheximide439.0TNF, ITGAL, IL13
47h2o2439.0IL13, ITGAL, TNF
48dexamethasone43 49 28 1211.9TNF, ITGAL, IL13
49nitric oxide43 24 1210.9TNF, ITGAL, IL13
50retinoic acid43 249.8TNF, ITGAL, IL13

GO Terms for genes affiliated with Actinic Prurigo

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Cellular components related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.0IL13, ITGAL, TNF, HLA-DRB1

Biological processes related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:00069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:00486618.8IL13, TNF
3inflammatory responseGO:00069548.5IL13, ITGAL, TNF

Molecular functions related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL13, TNF

Products for genes affiliated with Actinic Prurigo

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Sources for Actinic Prurigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet