MCID: ACT164
MIFTS: 30

Actinic Prurigo malady

Skin diseases, Genetic diseases categories

Summaries for Actinic Prurigo

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63Wikipedia, 32MalaCards
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Wikipedia:63 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to porphyria and erythropoietic protoporphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are Malaria and Cytokines and Inflammatory Response. The compounds cyclosporin a and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Actinic Prurigo

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
actinic prurigo:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood


Aliases & Descriptions:

actinic prurigo 48 60
hereditary polymorphous light eruption of american indians 48
familial polymorphous light eruption of american indians 48
hutchinson summer prurigo 48
hydroa aestivale 48


External Ids:

ICD10 via Orphanet26 L56.4

Related Diseases for Actinic Prurigo

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Clinical Features for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Actinic Prurigo

Search NIH Clinical Center for Actinic Prurigo

Search CenterWatch for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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32MalaCards
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MalaCards organs/tissues related to Actinic Prurigo:

32
Skin

Animal Models for Actinic Prurigo or affiliated genes

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Publications for Actinic Prurigo

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Genetic Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Actinic Prurigo

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Actinic Prurigo according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.3ITGAL
2pentoxifylline44 1111.2IL13
3gm-csf44 2811.0TNF
4nickel44 2410.8IL13, ITGAL
5glatiramer acetate44 1110.7HLA-DRB1, IL13
6theophylline44 28 11 2412.6IL13, ITGAL
7efalizumab44 1110.5ITGAL, TNF
8mip 1alpha449.5TNF, IL13
9il-12449.5IL13, TNF
10staurosporin449.5TNF, ITGAL
11indoleamine449.5TNF, IL13
12groalpha449.5TNF, IL13
13leflunomide49 44 1111.5TNF, IL13
14budesonide44 49 1111.5IL13, TNF
15fluticasone propionate44 49 59 1112.5TNF, IL13
16il 10449.4IL13, TNF
17gold sodium thiomalate449.4TNF, HLA-DRB1
18tarc449.4IL13, TNF
19n-formylmethionyl-leucylphenylalanine449.4ITGAL, TNF
20ccl344 2810.4IL13, TNF
21rituximab44 49 1111.3IL13, TNF
22thalidomide44 49 59 1112.2IL13, TNF
23allergens449.2IL13, ITGAL, HLA-DRB1
24chloroquine44 2 49 28 1113.2TNF, ITGAL
25alpha tocopherol449.1IL13, ITGAL
26leukotriene b444 59 2411.0IL13, ITGAL, TNF
27sp 60012544 5910.0TNF, IL13
28prednisolone44 28 1111.0TNF, ITGAL, IL13
29ionomycin449.0IL13, ITGAL, TNF
30fmlp449.0TNF, ITGAL, IL13
31tacrolimus44 49 1111.0IL13, ITGAL, TNF
32calcitriol44 59 11 2412.0TNF, ITGAL, IL13
33rantes449.0IL13, ITGAL, TNF
34actinomycin d449.0IL13, ITGAL, TNF
35pge2448.9TNF, ITGAL, IL13
36cycloheximide448.9TNF, ITGAL, IL13
37h2o2448.8TNF, ITGAL, IL13
38alanine448.8IL13, ITGAL, HLA-DRB1
39dexamethasone44 49 28 1111.8TNF, ITGAL, IL13
40nitric oxide44 11 2410.6IL13, ITGAL, TNF

GO Terms for genes affiliated with Actinic Prurigo

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16Gene Ontology
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Cellular components related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL13, ITGAL, HLA-DRB1, TNF

Biological processes related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, TNF
3inflammatory responseGO:0069548.5IL13, ITGAL, TNF

Products for genes affiliated with Actinic Prurigo

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Actinic Prurigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet