MCID: ACT164
MIFTS: 39

Actinic Prurigo malady

Genetic diseases, Skin diseases, Rare diseases categories

Summaries for Actinic Prurigo

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66Wikipedia, 34MalaCards
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Wikipedia:66 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to porphyria and congenital porphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and Epstein-Barr virus infection. The compounds nickel and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells.

Aliases & Classifications for Actinic Prurigo

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Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Orphanet: 50 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

50
actinic prurigo:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood


Aliases & Descriptions:

actinic prurigo 50 63
hereditary polymorphous light eruption of american indians 50
familial polymorphous light eruption of american indians 50
hutchinson summer prurigo 50
hydroa aestivale 50


External Ids:

ICD10 via Orphanet27 L56.4

Related Diseases for Actinic Prurigo

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria10.5
2congenital porphyria10.5
3cheilitis10.3
4erythropoietic protoporphyria10.3
5hypertrichosis10.3
6hydroa vacciniforme10.3
7cutaneous lupus erythematosus10.2
8conjunctivitis10.2
9lupus erythematosus10.2
10urticaria10.2
11b-cell lymphomas10.2
12solar urticaria10.2
13sialadenitis10.1ITGAL
14leishmaniasis10.1IL13
15leprosy10.1HLA-DRB1
16skin disease10.1HLA-DRB1
17spondylarthropathy10.0TNF, ITGAL
18pulmonary sarcoidosis10.0TNF, ITGAL
19asthma10.0TNF, IL13
20monocytic leukemia10.0ITGAL, TNF
21bullous pemphigoid10.0IL13, ITGAL
22allergic asthma10.0ITGAL, IL13
23pulmonary disease, chronic obstructive10.0IL13, TNF
24malaria10.0TNF, HLA-DRB1
25juvenile rheumatoid arthritis10.0HLA-DRB1, TNF
26sepsis10.0ITGAL, TNF
27viral hepatitis10.0ITGAL, HLA-DRB1
28connective tissue disease10.0TNF, HLA-DRB1
29atopic dermatitis10.0IL13, TNF
30primary biliary cirrhosis10.0HLA-DRB1, ITGAL
31hypersensitivity reaction type ii disease10.0HLA-DRB1, TNF
32hepatitis c10.0TNF, HLA-DRB1
33pneumonia10.0TNF, IL13
34cork-handlers' disease10.0TNF, ITGAL, IL13
35inflammatory bowel disease10.0TNF, ITGAL, IL13
36systemic scleroderma10.0HLA-DRB1, IL13
37hepatitis b10.0HLA-DRB1, ITGAL
38tuberculosis10.0ITGAL, TNF, HLA-DRB1
39systemic lupus erythematosus10.0ITGAL, HLA-DRB1, TNF
40psoriatic arthritis9.9HLA-DRB1, IL13, TNF
41sarcoidosis9.9IL13, TNF, HLA-DRB1
42graves' disease9.9IL13, HLA-DRB1, ITGAL
43ulcerative colitis9.9IL13, TNF, HLA-DRB1
44arthritis9.9IL13, HLA-DRB1, TNF
45non-hodgkin lymphoma9.9HLA-DRB1, ITGAL
46leukemia9.9TNF, HLA-DRB1, ITGAL
47graft versus host disease9.9IL13, ITGAL, TNF, HLA-DRB1
48psoriasis9.9TNF, HLA-DRB1, ITGAL, IL13
49multiple sclerosis9.9ITGAL, IL13, TNF, HLA-DRB1
50rheumatoid arthritis9.9ITGAL, HLA-DRB1, TNF, IL13

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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Sources:
34MalaCards
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MalaCards organs/tissues related to Actinic Prurigo:

34
Skin, Testes, B cells

Animal Models for Actinic Prurigo or affiliated genes

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Publications for Actinic Prurigo

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Sources:
53PubMed
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Articles related to Actinic Prurigo:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
2
Actinic prurigo: a case-control study of risk factors. (23968196)
2013
3
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
4
Case for diagnosis. Actinic prurigo. (21152806)
2010
5
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
6
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
7
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
8
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
9
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
10
Actinic prurigo in an Albanian girl. (16445427)
2006
11
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
12
Actinic prurigo. (16101881)
2005
13
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
14
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
15
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. (12193899)
2002
16
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
17
Long-term thalidomide for actinic prurigo. (11903163)
2001
18
Effectors of inflammation in actinic prurigo. (11369907)
2001
19
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
20
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. (11722460)
2001
21
Caucasian actinic prurigo: 8 cases observed in France. (11167711)
2001
22
Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. (11369906)
2001
23
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. (11124306)
2000
24
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
25
A case of actinic prurigo in Thailand. (10692819)
2000
26
The clinical features and management of actinic prurigo: a retrospective study. (10540941)
1999
27
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
28
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
29
Actinic prurigo: limited effect of PUVA. (9217842)
1997
30
Managing PLE and actinic prurigo. (9156494)
1997
31
What is actinic prurigo in Britain? (9372521)
1997
32
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
33
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
34
Actinic prurigo: an update. (7657433)
1995
35
Actinic prurigo. (7607801)
1995
36
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
37
Histopathology of actinic prurigo. (8214390)
1993
38
Actinic prurigo: clinical features and prognosis. (1583166)
1992
39
Actinic prurigo. (1587676)
1992
40
HLA typing in actinic prurigo. (1597562)
1992
41
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
45
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 61Thomson Reuters, 55R&D Systems, 56Reactome
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Pathways related to Actinic Prurigo according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DRB1, IL13
29.3ITGAL, HLA-DRB1
39.3HLA-DRB1, ITGAL
49.3HLA-DRB1, ITGAL
59.1IL13, TNF
6
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.1IL13, TNF
79.1IL13, TNF
89.1ITGAL, TNF
9
Show member pathways
9.1ITGAL, TNF
10
Show member pathways
Immune response CD16 signaling in NK cells61
9.1TNF, ITGAL
119.0TNF, HLA-DRB1
129.0TNF, HLA-DRB1
13
Show member pathways
8.6IL13, ITGAL, TNF
14
Show member pathways
8.6IL13, ITGAL, TNF
15
Show member pathways
8.6TNF, ITGAL, IL13
16
Show member pathways
8.5IL13, TNF, HLA-DRB1
17
Show member pathways
8.5IL13, TNF, HLA-DRB1
188.5IL13, TNF, HLA-DRB1
198.5HLA-DRB1, TNF, ITGAL
208.5HLA-DRB1, TNF, ITGAL
21
Show member pathways
8.0IL13, ITGAL, TNF, HLA-DRB1

Compounds for genes affiliated with Actinic Prurigo

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Actinic Prurigo according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1nickel46 2510.8ITGAL, IL13
2glatiramer acetate46 1210.8IL13, HLA-DRB1
3theophylline46 30 25 1212.7IL13, ITGAL
4alpha tocopherol469.6IL13, ITGAL
5efalizumab46 1210.6ITGAL, TNF
6mip 1alpha469.6TNF, IL13
7il-12469.6IL13, TNF
8indoleamine469.5IL13, TNF
9staurosporin469.5ITGAL, TNF
10groalpha469.5TNF, IL13
11leflunomide46 52 1211.5TNF, IL13
12gm-csf46 3010.5IL13, TNF
13budesonide46 52 1211.5TNF, IL13
14fluticasone propionate46 52 62 1212.5IL13, TNF
15rolipram46 62 3011.5IL13, TNF
16il 10469.5IL13, TNF
17tarc469.5TNF, IL13
18n-formylmethionyl-leucylphenylalanine469.5ITGAL, TNF
19pentoxifylline46 1210.5IL13, TNF
20ccl346 3010.5IL13, TNF
21gold sodium thiomalate469.5TNF, HLA-DRB1
22rituximab46 52 1211.4IL13, TNF
23cyclophosphamide46 52 1211.4IL13, ITGAL
24thalidomide46 52 62 1212.4IL13, TNF
25chloroquine46 3 52 30 1213.4ITGAL, TNF
26sp 60012546 6210.3IL13, TNF
27hyaluronic acid46 2510.3IL13, ITGAL
28allergens469.3IL13, ITGAL, HLA-DRB1
29hydrocortisone46 3 62 1212.2IL13, TNF
30tgf beta1469.2IL13, TNF
31simvastatin46 52 62 30 25 1214.1TNF, ITGAL
32mannose469.1IL13, ITGAL
33leukotriene b446 62 2511.1IL13, ITGAL, TNF
34prednisolone46 30 1211.1TNF, ITGAL, IL13
35endotoxin469.1IL13, ITGAL, TNF
36ionomycin469.1IL13, ITGAL, TNF
37fmlp469.1TNF, ITGAL, IL13
38glutamate469.0IL13, ITGAL, HLA-DRB1
39tacrolimus46 52 1211.0IL13, ITGAL, TNF
40calcitriol46 62 25 1212.0TNF, ITGAL, IL13
41rantes469.0IL13, ITGAL, TNF
42alanine469.0HLA-DRB1, ITGAL, IL13
43actinomycin d469.0TNF, ITGAL, IL13
44cyclosporin a46 30 6211.0TNF, ITGAL, IL13
45pge2469.0IL13, ITGAL, TNF
46cycloheximide469.0TNF, ITGAL, IL13
47h2o2469.0IL13, ITGAL, TNF
48dexamethasone46 52 30 1211.9TNF, ITGAL, IL13
49nitric oxide46 25 1210.9TNF, ITGAL, IL13
50retinoic acid46 259.8TNF, ITGAL, IL13

GO Terms for genes affiliated with Actinic Prurigo

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Sources:
17Gene Ontology
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Cellular components related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL13, ITGAL, TNF, HLA-DRB1

Biological processes related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, TNF
3inflammatory responseGO:0069548.5IL13, ITGAL, TNF

Molecular functions related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL13, TNF

Products for genes affiliated with Actinic Prurigo

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  • Antibodies
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Sources for Actinic Prurigo

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet