MCID: ACT164
MIFTS: 36

Actinic Prurigo malady

Genetic diseases, Skin diseases, Rare diseases categories

Aliases & Classifications for Actinic Prurigo

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Actinic Prurigo:

Name: Actinic Prurigo 51 65
Hereditary Polymorphous Light Eruption of American Indians 51
Familial Polymorphous Light Eruption of American Indians 51
 
Hutchinson Summer Prurigo 51
Hydroa Aestivale 51
Hydroa Estivale 65


Classifications:

Orphanet: 51 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

51
actinic prurigo:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood


External Ids:

Orphanet51 330061
ICD10 via Orphanet28 L56.4

Summaries for Actinic Prurigo

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Wikipedia:68 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards based summary: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to dermatitis and porphyria. An important gene associated with Actinic Prurigo is TNF (Tumor Necrosis Factor), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include skin, b cells and testes, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Actinic Prurigo

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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.6IL1B, TNF
2porphyria10.5
3congenital porphyria10.5
4hypertrichosis10.4
5hydroa vacciniforme10.4
6cheilitis10.3
7aorta atresia10.3IL13, TNF
8meckel's diverticulitis10.3IL1B, TNF
9stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IL1B, TNF
10peyronie's disease10.3IL1B, TNF
11plantar nerve lesion10.3IL1B, TNF
12larynx sarcoma10.3IL1B, TNF
13waardenburg syndrome type 410.3IL1B, TNF
14lymphoepithelioma-like carcinoma10.3IL1B, TNF
15wissler's syndrome10.3IL1B, TNF
16calpainopathy10.3IL1B, TNF
17cervicomedullary junction neoplasm10.2IL13, SELE
18scleroderma10.2SELE, TNF
19sparganosis10.2CD2, ICAM1
20autoimmune gastrointestinal dysmotility10.2ICAM1, ITGAL
21best1 retinopathy10.2HLA-DRB1, TNF
22intermediate cell type choroid melanoma10.2IL1B, TNF
23microsomia hemifacial radial defects10.2HLA-DRB1, TNF
24chemical colitis10.2ICAM1, IL1B
25fallopian tube cystadenofibroma10.2IL1B, TNF
26hepatic angiomyolipoma10.2IL1B, TNF
27anaerobic pneumonia10.2ICAM1, SELE
28pneumonic tularemia10.2IL1B, TNF
29chorioamnionitis10.2IL1B, SELE
30clear cell renal cell carcinoma10.2IL13, IL1B, TNF
31pyknoachondrogenesis10.2ITGAL, SELE, TNF
32b-cell lymphomas10.2
33cutaneous lupus erythematosus10.2
34allergic contact dermatitis10.2
35conjunctivitis10.2
36contact dermatitis10.2
37lupus erythematosus10.2
38urticaria10.2
39solar urticaria10.2
40lumbosacral plexus lesion10.2ICAM1, SELE
41restrictive cardiomyopathy10.2IL13, IL1B, TNF
42pediatric t-cell leukemia10.2HLA-DRB1, ITGA4
43silver-russell syndrome due to maternal uniparental disomy of chromosome 710.2SELE, VCAM1
44pneumothorax10.2IL13, IL1B, TNF
45periodic limb movement disorder10.2ICAM1, ITGAL, TNF
46littre gland carcinoma10.2IL13, IL1B, TNF
47endophthalmitis10.2IL1B, SELE, TNF
48herpangina10.2CD2, ICAM1, TNF
49keratosis10.2ICAM1, IL13, TNF
50chromoblastomycosis10.2ICAM1, TNF

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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MalaCards organs/tissues related to Actinic Prurigo:

33
Skin, B cells, Testes

Animal Models for Actinic Prurigo or affiliated genes

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MGI Mouse Phenotypes related to Actinic Prurigo:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CD69, ICAM1, IL13, IL1B, ITGA4, ITGAL
2MP:00053876.7CD69, ICAM1, IL13, IL1B, ITGA4, ITGAL

Publications for Actinic Prurigo

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Articles related to Actinic Prurigo:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Allergic contact dermatitis to Parthenium hysterophorus mimicking actinic prurigo. (25566915)
2015
2
Actinic prurigo of the lip: Two case reports. (25133153)
2014
3
Determination of apoptosis in actinic prurigo by TUNEL technique. (25377923)
2014
4
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
5
Actinic prurigo: a case-control study of risk factors. (23968196)
2013
6
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
7
Case for diagnosis. Actinic prurigo. (21152806)
2010
8
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
9
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
10
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
11
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
12
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
13
Actinic prurigo in an Albanian girl. (16445427)
2006
14
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
15
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
16
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
17
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. (12193899)
2002
18
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
19
Long-term thalidomide for actinic prurigo. (11903163)
2001
20
Effectors of inflammation in actinic prurigo. (11369907)
2001
21
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
22
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. (11722460)
2001
23
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. (11124306)
2000
24
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
25
A case of actinic prurigo in Thailand. (10692819)
2000
26
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
27
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
28
Actinic prurigo: limited effect of PUVA. (9217842)
1997
29
Managing PLE and actinic prurigo. (9156494)
1997
30
What is actinic prurigo in Britain? (9372521)
1997
31
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
32
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
33
Actinic prurigo: an update. (7657433)
1995
34
Actinic prurigo. (7607801)
1995
35
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
36
Histopathology of actinic prurigo. (8214390)
1993
37
Actinic prurigo: clinical features and prognosis. (1583166)
1992
38
Actinic prurigo. (1587676)
1992
39
HLA typing in actinic prurigo. (1597562)
1992
40
Treatment of actinic prurigo with intermittent short-course topical 0.05% clobetasol 17-propionate. A preliminary report. (2396838)
1990
41
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
45
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Pathways related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL13, IL1B
2
Show member pathways
9.6IL13, IL1B, TNF
3
Show member pathways
9.6IL13, IL1B, ITGA4
49.5ICAM1, IL1B, TNF
5
Show member pathways
9.5ICAM1, IL1B, TNF
69.5ICAM1, IL13, SELE
79.4IL1B, TNF, VCAM1
89.4ICAM1, TNF, VCAM1
99.3ICAM1, ITGA4, VCAM1
109.3ICAM1, SELE, VCAM1
119.2HLA-DRB1, IL13, IL1B, TNF
12
Show member pathways
9.2HLA-DRB1, IL1B, ITGA4, TNF
13
Show member pathways
9.1ITGA4, ITGAL, VCAM1
149.1ICAM1, IL1B, TNF, VCAM1
159.1ICAM1, IL1B, TNF, VCAM1
169.1HLA-DRB1, ICAM1, ITGAL
178.9CD2, HLA-DRB1, IL1B, ITGA4, TNF
18
Show member pathways
8.8HLA-DRB1, ICAM1, IL13, IL1B, TNF
198.7ICAM1, IL1B, SELE, TNF, VCAM1
208.7ICAM1, IL1B, SELE, TNF, VCAM1
218.7ICAM1, ITGA4, ITGAL, VCAM1
228.5CD58, HLA-DRB1, ICAM1, ITGAL
238.5HLA-DRB1, ICAM1, IL1B, ITGAL, TNF
24
Show member pathways
8.4CD2, IL13, IL1B, ITGA4, ITGAL, TNF
258.4HLA-DRB1, ICAM1, ITGAL, TNF, VCAM1
268.1ICAM1, IL1B, ITGAL, SELE, TNF, VCAM1
27
Show member pathways
7.9CD2, CD58, ITGA4, ITGAL, SELE, VCAM1
28
Show member pathways
7.9CD2, CD58, ITGA4, ITGAL, SELE, VCAM1
29
Show member pathways
7.9HLA-DRB1, ICAM1, IL13, IL1B, ITGA4, ITGAL
307.9ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
317.9ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
32
Show member pathways
7.9ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
337.9ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
34
Show member pathways
6.9HLA-DRB1, ICAM1, ICAM3, IL1B, ITGA4, ITGAL
356.3CD2, CD58, HLA-DRB1, ICAM1, ICAM3, ITGA4

GO Terms for genes affiliated with Actinic Prurigo

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Cellular components related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2ICAM1, IL13, IL1B, SELE, TNF, VCAM1
2integral component of plasma membraneGO:00058877.7CD2, CD58, CD69, HLA-DRB1, ICAM1, ICAM3
3external side of plasma membraneGO:00098977.6CD2, CD69, HLA-DRB1, ICAM1, IL13, ITGA4
4cell surfaceGO:00099867.2CD2, CD58, HLA-DRB1, ICAM1, ITGA4, ITGAL
5membraneGO:00160206.9CD58, HLA-DRB1, ICAM1, ICAM3, ITGA4, ITGAL
6extracellular exosomeGO:00700626.6CD58, HLA-DRB1, ICAM1, ICAM3, IL1B, ITGA4
7plasma membraneGO:00058866.1CD2, CD58, HLA-DRB1, ICAM1, ICAM3, ITGA4

Biological processes related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:003073010.6IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
3regulation of establishment of endothelial barrierGO:190314010.6IL1B, TNF
4chronic inflammatory response to antigenic stimulusGO:000243910.6IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
6positive regulation of membrane protein ectodomain proteolysisGO:005104410.6IL1B, TNF
7negative regulation of lipid catabolic processGO:005099510.6IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:004234610.5IL1B, TNF
10positive regulation of fever generationGO:003162210.5IL1B, TNF
11negative regulation of endothelial cell apoptotic processGO:200035210.5ICAM1, IL13
12positive regulation of interleukin-8 productionGO:003275710.5IL1B, TNF
13positive regulation of leukocyte migrationGO:000268710.4ITGA4, SELE
14inflammatory response to antigenic stimulusGO:000243710.4HLA-DRB1, IL1B
15regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
16cellular response to cytokine stimulusGO:007134510.3IL13, ITGA4
17membrane to membrane dockingGO:002261410.3ICAM1, VCAM1
18positive regulation of interleukin-8 secretionGO:200048410.3CD2, CD58
19T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:000229110.2ICAM1, ITGAL
20receptor clusteringGO:004311310.1ITGA4, ITGAL
21positive regulation of NF-kappaB transcription factor activityGO:005109210.0ICAM1, IL1B, TNF
22cellular response to lipopolysaccharideGO:007122210.0ICAM1, IL1B, TNF
23heterotypic cell-cell adhesionGO:003411310.0CD2, CD58, ITGA4
24positive regulation of nitric oxide biosynthetic processGO:00454299.9ICAM1, IL1B, TNF
25positive regulation of ERK1 and ERK2 cascadeGO:00703749.9ICAM1, IL1B, TNF
26response to ethanolGO:00454719.9ICAM1, IL13, IL1B
27interferon-gamma-mediated signaling pathwayGO:00603339.9HLA-DRB1, ICAM1, VCAM1
28leukocyte tethering or rollingGO:00509019.8ITGA4, SELE, TNF, VCAM1
29immune responseGO:00069559.7HLA-DRB1, IL13, IL1B, TNF
30response to lipopolysaccharideGO:00324969.6ICAM1, IL13, IL1B, SELE
31positive regulation of T cell proliferationGO:00421029.5IL1B, ITGAL, VCAM1
32cell-matrix adhesionGO:00071609.4ITGA4, ITGAL, VCAM1
33cytokine-mediated signaling pathwayGO:00192219.3HLA-DRB1, ICAM1, IL1B, VCAM1
34inflammatory responseGO:00069549.1IL13, IL1B, ITGAL, SELE, TNF
35heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071578.9ICAM1, ITGA4, ITGAL, SELE, VCAM1
36leukocyte cell-cell adhesionGO:00071598.9ICAM1, ITGA4, ITGAL, SELE, VCAM1
37single organismal cell-cell adhesionGO:00163378.4CD2, CD58, ICAM1, ICAM3, VCAM1
38regulation of immune responseGO:00507768.1ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
39blood coagulationGO:00075968.1CD2, CD58, ITGA4, ITGAL, SELE
40leukocyte migrationGO:00509007.9CD2, CD58, ICAM1, IL1B, ITGA4, ITGAL
41extracellular matrix organizationGO:00301987.6ICAM1, ICAM3, ITGA4, ITGAL, TNF, VCAM1
42cell adhesionGO:00071557.1CD2, CD58, ICAM1, ICAM3, ITGA4, ITGAL

Molecular functions related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:00508399.2ITGA4, ITGAL, VCAM1
2integrin bindingGO:00051788.8ICAM1, ICAM3, VCAM1

Sources for Actinic Prurigo

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet