MCID: ACT164
MIFTS: 32

Actinic Prurigo malady

Skin, Genetic categories

Summaries for Actinic Prurigo

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to congenital porphyria and erythropoietic protoporphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are Malaria and Cytokines and Inflammatory Response. The compounds cyclosporin a and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin and b cells.

Aliases & Classifications for Actinic Prurigo

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
actinic prurigo:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood


Aliases & Descriptions:

actinic prurigo 49 61
hereditary polymorphous light eruption of american indians 49
familial polymorphous light eruption of american indians 49
hutchinson summer prurigo 49
hydroa aestivale 49


External Ids:

ICD10 via Orphanet26 L56.4

Related Diseases for Actinic Prurigo

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Clinical Features for Actinic Prurigo

Drugs & Therapeutics for Actinic Prurigo

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Actinic Prurigo

Drug clinical trials:

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Search NIH Clinical Center for Actinic Prurigo

Search CenterWatch for Actinic Prurigo

Genetic Tests for Actinic Prurigo

Anatomical Context for Actinic Prurigo

Sources:
33MalaCards
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MalaCards organs/tissues related to Actinic Prurigo:

33
Skin, B cells

Animal Models for Actinic Prurigo or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Actinic Prurigo

Sources:
51PubMed
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Articles related to Actinic Prurigo:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
2
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
3
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
4
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
5
Actinic prurigo. (18811871)
2008
6
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
7
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
8
Actinic prurigo in an Albanian girl. (16445427)
2006
9
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
10
Immune responses to isolated human skin antigens in actinic prurigo. (16501416)
2006
11
Primary cutaneous B-cell lymphoma associated with actinic prurigo. (16029348)
2005
12
Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. (15118367)
2004
13
Diagnosis and treatment of actinic prurigo. (12919125)
2003
14
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
15
Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A. (12010338)
2002
16
Effectors of inflammation in actinic prurigo. (11369907)
2001
17
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
18
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
19
A case of actinic prurigo in Thailand. (10692819)
2000
20
The conjunctivitis of solar (actinic) prurigo. (11123772)
2000
21
Genetic modeling of abnormal photosensitivity in families with polymorphic light eruption and actinic prurigo. (10951286)
2000
22
Major gene segregation of actinic prurigo among North American Indians in Saskatchewan. (10817657)
2000
23
The clinical features and management of actinic prurigo: a retrospective study. (10540941)
1999
24
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
25
Actinic prurigo: limited effect of PUVA. (9217842)
1997
26
Managing PLE and actinic prurigo. (9156494)
1997
27
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
28
Actinic prurigo. (9372522)
1997
29
Actinic prurigo and HLA-DR4. (9008241)
1997
30
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
31
Treatment of actinic prurigo in Chimila Indians. (8737876)
1996
32
Actinic prurigo: an update. (7657433)
1995
33
Actinic prurigo. (8157403)
1994
34
Histopathology of actinic prurigo. (8214390)
1993
35
Actinic prurigo, tropical (South-East Asian) variant. (1342193)
1992-1993
36
HLA typing in actinic prurigo. (1597562)
1992
37
Cellular immune effects of thalidomide in actinic prurigo. (1428460)
1992
38
A case of actinic prurigo and solar urticaria. (2208779)
1990
39
HLA typing in actinic prurigo. (2370326)
1990
40
Actinic prurigo at sea level in Colombia. (2722335)
1989
41
Patch testing in actinic prurigo. (2598651)
1989
42
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
43
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
44
Actinic prurigo--a specific photodermatosis? (6527952)
1984
45
Actinic prurigo. (6629604)
1983
46
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
47
Actinic prurigo: a case report with successful induction of skin lesions. (7398126)
1980
48
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
49
Thalidomide in the treatment of actinic prurigo. (4747626)
1973
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Genetic Variations for Actinic Prurigo

Expression for genes affiliated with Actinic Prurigo

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Actinic Prurigo

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Actinic Prurigo according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1cyclosporin a45 29 6012.3ITGAL
2pentoxifylline45 1111.2IL13
3gm-csf45 2911.0TNF
4nickel45 2410.8IL13, ITGAL
5glatiramer acetate45 1110.7HLA-DRB1, IL13
6theophylline45 29 11 2412.6IL13, ITGAL
7efalizumab45 1110.5ITGAL, TNF
8mip 1alpha459.5TNF, IL13
9il-12459.5IL13, TNF
10staurosporin459.5TNF, ITGAL
11indoleamine459.5TNF, IL13
12groalpha459.5TNF, IL13
13leflunomide50 45 1111.5TNF, IL13
14budesonide45 50 1111.5IL13, TNF
15fluticasone propionate45 50 60 1112.5TNF, IL13
16il 10459.4IL13, TNF
17gold sodium thiomalate459.4TNF, HLA-DRB1
18tarc459.4IL13, TNF
19n-formylmethionyl-leucylphenylalanine459.4ITGAL, TNF
20ccl345 2910.4IL13, TNF
21rituximab45 50 1111.3IL13, TNF
22thalidomide45 50 60 1112.2IL13, TNF
23allergens459.2IL13, ITGAL, HLA-DRB1
24chloroquine45 2 50 29 1113.2TNF, ITGAL
25alpha tocopherol459.1IL13, ITGAL
26leukotriene b445 60 2411.0IL13, ITGAL, TNF
27sp 60012545 6010.0TNF, IL13
28prednisolone45 29 1111.0TNF, ITGAL, IL13
29ionomycin459.0IL13, ITGAL, TNF
30fmlp459.0TNF, ITGAL, IL13
31tacrolimus45 50 1111.0IL13, ITGAL, TNF
32calcitriol45 60 11 2412.0TNF, ITGAL, IL13
33rantes459.0IL13, ITGAL, TNF
34actinomycin d459.0IL13, ITGAL, TNF
35pge2458.9TNF, ITGAL, IL13
36cycloheximide458.9TNF, ITGAL, IL13
37h2o2458.8TNF, ITGAL, IL13
38alanine458.8IL13, ITGAL, HLA-DRB1
39dexamethasone45 50 29 1111.8TNF, ITGAL, IL13
40nitric oxide45 11 2410.6IL13, ITGAL, TNF

GO Terms for genes affiliated with Actinic Prurigo

Sources:
16Gene Ontology
See all sources

Cellular components related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL13, ITGAL, HLA-DRB1, TNF

Biological processes related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, TNF
3inflammatory responseGO:0069548.5IL13, ITGAL, TNF

Products for genes affiliated with Actinic Prurigo

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Actinic Prurigo

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet