MCID: ACT164
MIFTS: 39

Actinic Prurigo malady

Genetic diseases, Skin diseases, Rare diseases categories
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Summaries for Actinic Prurigo

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to porphyria and congenital porphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and Epstein-Barr virus infection. The compounds nickel and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells.

Aliases & Classifications for Actinic Prurigo

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Sources:
49Orphanet, 62UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

49
actinic prurigo:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood


Aliases & Descriptions:

actinic prurigo 49 62
hereditary polymorphous light eruption of american indians 49
familial polymorphous light eruption of american indians 49
hutchinson summer prurigo 49
hydroa aestivale 49


External Ids:

ICD10 via Orphanet26 L56.4

Related Diseases for Actinic Prurigo

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria10.5
2congenital porphyria10.5
3cheilitis10.3
4erythropoietic protoporphyria10.3
5hypertrichosis10.3
6hydroa vacciniforme10.3
7cutaneous lupus erythematosus10.2
8conjunctivitis10.2
9lupus erythematosus10.2
10urticaria10.2
11b-cell lymphomas10.2
12solar urticaria10.2
13sialadenitis10.1ITGAL
14leishmaniasis10.1IL13
15leprosy10.1HLA-DRB1
16skin disease10.1HLA-DRB1
17spondylarthropathy10.0TNF, ITGAL
18pulmonary sarcoidosis10.0TNF, ITGAL
19asthma10.0TNF, IL13
20monocytic leukemia10.0ITGAL, TNF
21bullous pemphigoid10.0IL13, ITGAL
22allergic asthma10.0ITGAL, IL13
23pulmonary disease, chronic obstructive10.0IL13, TNF
24malaria10.0TNF, HLA-DRB1
25juvenile rheumatoid arthritis10.0HLA-DRB1, TNF
26sepsis10.0ITGAL, TNF
27viral hepatitis10.0ITGAL, HLA-DRB1
28connective tissue disease10.0TNF, HLA-DRB1
29atopic dermatitis10.0IL13, TNF
30primary biliary cirrhosis10.0HLA-DRB1, ITGAL
31hypersensitivity reaction type ii disease10.0HLA-DRB1, TNF
32hepatitis c10.0TNF, HLA-DRB1
33pneumonia10.0TNF, IL13
34cork-handlers' disease10.0TNF, ITGAL, IL13
35inflammatory bowel disease10.0TNF, ITGAL, IL13
36systemic scleroderma10.0HLA-DRB1, IL13
37hepatitis b10.0HLA-DRB1, ITGAL
38tuberculosis10.0ITGAL, TNF, HLA-DRB1
39systemic lupus erythematosus10.0ITGAL, HLA-DRB1, TNF
40psoriatic arthritis9.9HLA-DRB1, IL13, TNF
41sarcoidosis9.9IL13, TNF, HLA-DRB1
42graves' disease9.9IL13, HLA-DRB1, ITGAL
43ulcerative colitis9.9IL13, TNF, HLA-DRB1
44arthritis9.9IL13, HLA-DRB1, TNF
45non-hodgkin lymphoma9.9HLA-DRB1, ITGAL
46leukemia9.9TNF, HLA-DRB1, ITGAL
47graft versus host disease9.9IL13, ITGAL, TNF, HLA-DRB1
48psoriasis9.9TNF, HLA-DRB1, ITGAL, IL13
49multiple sclerosis9.9ITGAL, IL13, TNF, HLA-DRB1
50rheumatoid arthritis9.9ITGAL, HLA-DRB1, TNF, IL13

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Actinic Prurigo

Search NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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Sources:
33MalaCards
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MalaCards organs/tissues related to Actinic Prurigo:

33
Skin, Testes, B cells

Animal Models for Actinic Prurigo or affiliated genes

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Publications for Actinic Prurigo

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Sources:
52PubMed
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Articles related to Actinic Prurigo:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
2
Actinic prurigo: a case-control study of risk factors. (23968196)
2013
3
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
4
Case for diagnosis. Actinic prurigo. (21152806)
2010
5
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
6
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
7
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
8
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
9
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
10
Actinic prurigo in an Albanian girl. (16445427)
2006
11
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
12
Actinic prurigo. (16101881)
2005
13
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
14
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
15
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. (12193899)
2002
16
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
17
Long-term thalidomide for actinic prurigo. (11903163)
2001
18
Effectors of inflammation in actinic prurigo. (11369907)
2001
19
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
20
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. (11722460)
2001
21
Caucasian actinic prurigo: 8 cases observed in France. (11167711)
2001
22
Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. (11369906)
2001
23
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. (11124306)
2000
24
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
25
A case of actinic prurigo in Thailand. (10692819)
2000
26
The clinical features and management of actinic prurigo: a retrospective study. (10540941)
1999
27
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
28
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
29
Actinic prurigo: limited effect of PUVA. (9217842)
1997
30
Managing PLE and actinic prurigo. (9156494)
1997
31
What is actinic prurigo in Britain? (9372521)
1997
32
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
33
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
34
Actinic prurigo: an update. (7657433)
1995
35
Actinic prurigo. (7607801)
1995
36
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
37
Histopathology of actinic prurigo. (8214390)
1993
38
Actinic prurigo: clinical features and prognosis. (1583166)
1992
39
Actinic prurigo. (1587676)
1992
40
HLA typing in actinic prurigo. (1597562)
1992
41
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
45
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters, 54R&D Systems, 55Reactome
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Pathways related to Actinic Prurigo according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DRB1, IL13
29.3ITGAL, HLA-DRB1
39.3HLA-DRB1, ITGAL
49.3HLA-DRB1, ITGAL
59.1IL13, TNF
6
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.1IL13, TNF
79.1IL13, TNF
89.1ITGAL, TNF
9
Show member pathways
9.1ITGAL, TNF
10
Show member pathways
Immune response CD16 signaling in NK cells60
9.1TNF, ITGAL
119.0TNF, HLA-DRB1
129.0TNF, HLA-DRB1
13
Show member pathways
8.6IL13, ITGAL, TNF
14
Show member pathways
8.6IL13, ITGAL, TNF
15
Show member pathways
8.6TNF, ITGAL, IL13
16
Show member pathways
8.5IL13, TNF, HLA-DRB1
17
Show member pathways
8.5IL13, TNF, HLA-DRB1
188.5IL13, TNF, HLA-DRB1
198.5HLA-DRB1, TNF, ITGAL
208.5HLA-DRB1, TNF, ITGAL
21
Show member pathways
8.0IL13, ITGAL, TNF, HLA-DRB1

Compounds for genes affiliated with Actinic Prurigo

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Actinic Prurigo according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1nickel45 2410.8ITGAL, IL13
2glatiramer acetate45 1110.8IL13, HLA-DRB1
3theophylline45 29 24 1112.7IL13, ITGAL
4alpha tocopherol459.6IL13, ITGAL
5efalizumab45 1110.6ITGAL, TNF
6mip 1alpha459.6TNF, IL13
7il-12459.6IL13, TNF
8indoleamine459.5IL13, TNF
9staurosporin459.5ITGAL, TNF
10groalpha459.5TNF, IL13
11leflunomide45 51 1111.5TNF, IL13
12gm-csf45 2910.5IL13, TNF
13budesonide45 51 1111.5TNF, IL13
14fluticasone propionate45 51 61 1112.5IL13, TNF
15rolipram45 61 2911.5IL13, TNF
16il 10459.5IL13, TNF
17tarc459.5TNF, IL13
18n-formylmethionyl-leucylphenylalanine459.5ITGAL, TNF
19pentoxifylline45 1110.5IL13, TNF
20ccl345 2910.5IL13, TNF
21gold sodium thiomalate459.5TNF, HLA-DRB1
22rituximab45 51 1111.4IL13, TNF
23cyclophosphamide45 51 1111.4IL13, ITGAL
24thalidomide45 51 61 1112.4IL13, TNF
25chloroquine45 3 51 29 1113.4ITGAL, TNF
26sp 60012545 6110.3IL13, TNF
27hyaluronic acid45 2410.3IL13, ITGAL
28allergens459.3IL13, ITGAL, HLA-DRB1
29hydrocortisone45 3 61 1112.2IL13, TNF
30tgf beta1459.2IL13, TNF
31simvastatin45 51 61 29 24 1114.1TNF, ITGAL
32mannose459.1IL13, ITGAL
33leukotriene b445 61 2411.1IL13, ITGAL, TNF
34prednisolone45 29 1111.1TNF, ITGAL, IL13
35endotoxin459.1IL13, ITGAL, TNF
36ionomycin459.1IL13, ITGAL, TNF
37fmlp459.1TNF, ITGAL, IL13
38glutamate459.0IL13, ITGAL, HLA-DRB1
39tacrolimus45 51 1111.0IL13, ITGAL, TNF
40calcitriol45 61 24 1112.0TNF, ITGAL, IL13
41rantes459.0IL13, ITGAL, TNF
42alanine459.0HLA-DRB1, ITGAL, IL13
43actinomycin d459.0TNF, ITGAL, IL13
44cyclosporin a45 29 6111.0TNF, ITGAL, IL13
45pge2459.0IL13, ITGAL, TNF
46cycloheximide459.0TNF, ITGAL, IL13
47h2o2459.0IL13, ITGAL, TNF
48dexamethasone45 51 29 1111.9TNF, ITGAL, IL13
49nitric oxide45 24 1110.9TNF, ITGAL, IL13
50retinoic acid45 249.8TNF, ITGAL, IL13

GO Terms for genes affiliated with Actinic Prurigo

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16Gene Ontology
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Cellular components related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL13, ITGAL, TNF, HLA-DRB1

Biological processes related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, TNF
3inflammatory responseGO:0069548.5IL13, ITGAL, TNF

Molecular functions related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL13, TNF

Products for genes affiliated with Actinic Prurigo

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  • Antibodies
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Sources for Actinic Prurigo

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet