MCID: ACT164
MIFTS: 40

Actinic Prurigo malady

Genetic diseases, Skin diseases, Rare diseases categories
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Summaries for Actinic Prurigo

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Wikipedia:65 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards based summary: Actinic Prurigo, also known as hydroa aestivale, is related to porphyria and congenital porphyria. An important gene associated with Actinic Prurigo is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and Epstein-Barr virus infection. The compounds nickel and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells.

Aliases & Classifications for Actinic Prurigo

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Actinic Prurigo, Aliases & Descriptions:

Name: Actinic Prurigo 48 62
Hydroa Aestivale 48 62
Hereditary Polymorphous Light Eruption of American Indians 48
 
Familial Polymorphous Light Eruption of American Indians 48
Hutchinson's Summer Prurigo 62
Hutchinson Summer Prurigo 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Orphanet: 48 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

48
hydroa aestivale:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood


External Ids:

ICD10 via Orphanet26 L56.4

Related Diseases for Actinic Prurigo

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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria10.5
2congenital porphyria10.5
3sialadenitis10.4ITGAL
4leishmaniasis10.3IL13
5erythropoietic protoporphyria10.3
6hypertrichosis10.3
7hydroa vacciniforme10.3
8cheilitis10.3
9leprosy10.3HLA-DRB1
10skin disease10.2HLA-DRB1
11spondylarthropathy10.2TNF, ITGAL
12b-cell lymphomas10.2
13cutaneous lupus erythematosus10.2
14conjunctivitis10.2
15lupus erythematosus10.2
16urticaria10.2
17solar urticaria10.2
18pulmonary sarcoidosis10.2TNF, ITGAL
19asthma10.1TNF, IL13
20monocytic leukemia10.1ITGAL, TNF
21bullous pemphigoid10.1IL13, ITGAL
22colitis10.1IL13, TNF
23allergic asthma10.1ITGAL, IL13
24chronic obstructive pulmonary disease10.0IL13, TNF
25malaria10.0TNF, HLA-DRB1
26juvenile rheumatoid arthritis10.0HLA-DRB1, TNF
27viral hepatitis10.0ITGAL, HLA-DRB1
28sepsis10.0ITGAL, TNF
29connective tissue disease10.0TNF, HLA-DRB1
30primary biliary cirrhosis10.0HLA-DRB1, ITGAL
31atopic dermatitis10.0IL13, TNF
32hypersensitivity reaction type ii disease10.0HLA-DRB1, TNF
33hepatitis c10.0TNF, HLA-DRB1
34pneumonia10.0TNF, IL13
35cork-handlers' disease9.9TNF, ITGAL, IL13
36inflammatory bowel disease9.9TNF, ITGAL, IL13
37systemic scleroderma9.9HLA-DRB1, IL13
38hepatitis b9.8HLA-DRB1, ITGAL
39tuberculosis9.8ITGAL, TNF, HLA-DRB1
40systemic lupus erythematosus9.8ITGAL, HLA-DRB1, TNF
41psoriatic arthritis9.8HLA-DRB1, IL13, TNF
42sarcoidosis9.8IL13, TNF, HLA-DRB1
43graves' disease9.8IL13, HLA-DRB1, ITGAL
44ulcerative colitis9.8IL13, TNF, HLA-DRB1
45arthritis9.8IL13, HLA-DRB1, TNF
46non-hodgkin lymphoma9.8HLA-DRB1, ITGAL
47leukemia9.7TNF, HLA-DRB1, ITGAL
48graft versus host disease9.6IL13, ITGAL, TNF, HLA-DRB1
49psoriasis9.6TNF, HLA-DRB1, ITGAL, IL13
50multiple sclerosis9.6ITGAL, IL13, TNF, HLA-DRB1

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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Drugs & Therapeutics for Actinic Prurigo

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Drug clinical trials:

Search ClinicalTrials for Actinic Prurigo

Search NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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MalaCards organs/tissues related to Actinic Prurigo:

32
Skin, Testes, B cells

Animal Models for Actinic Prurigo or affiliated genes

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Publications for Actinic Prurigo

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Articles related to Actinic Prurigo:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Actinic prurigo of the lip: Two case reports. (25133153)
2014
2
Determination of apoptosis in actinic prurigo by TUNEL technique. (25377923)
2014
3
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
4
Actinic prurigo: a case-control study of risk factors. (23968196)
2013
5
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
6
Case for diagnosis. Actinic prurigo. (21152806)
2010
7
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. (19335731)
2009
8
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
9
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
10
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. (17355228)
2007
11
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
12
Actinic prurigo in an Albanian girl. (16445427)
2006
13
Successful thalidomide therapy for actinic prurigo in a European woman. (17081272)
2006
14
Actinic prurigo. (16101881)
2005
15
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
16
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
17
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. (12193899)
2002
18
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
19
Long-term thalidomide for actinic prurigo. (11903163)
2001
20
Effectors of inflammation in actinic prurigo. (11369907)
2001
21
A case of severe actinic prurigo successfully treated with thalidomide. (11488714)
2001
22
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. (11722460)
2001
23
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. (11124306)
2000
24
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
25
A case of actinic prurigo in Thailand. (10692819)
2000
26
The clinical features and management of actinic prurigo: a retrospective study. (10540941)
1999
27
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
28
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
29
Actinic prurigo: limited effect of PUVA. (9217842)
1997
30
Managing PLE and actinic prurigo. (9156494)
1997
31
What is actinic prurigo in Britain? (9372521)
1997
32
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
33
Actinic prurigo: an update. (7657433)
1995
34
Actinic prurigo. (7607801)
1995
35
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
36
Histopathology of actinic prurigo. (8214390)
1993
37
Actinic prurigo: clinical features and prognosis. (1583166)
1992
38
Actinic prurigo. (1587676)
1992
39
HLA typing in actinic prurigo. (1597562)
1992
40
Treatment of actinic prurigo with intermittent short-course topical 0.05% clobetasol 17-propionate. A preliminary report. (2396838)
1990
41
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. (3380896)
1988
45
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo (Hutchinson's summer prurigo). (603975)
1977
50
Photodermatitis in North American Indians: familial actinic prurigo. (5558222)
1971

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Expression patterns in normal tissues for genes affiliated with Actinic Prurigo

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Pathways for genes affiliated with Actinic Prurigo

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Pathways related to Actinic Prurigo according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-DRB1, IL13
29.3ITGAL, HLA-DRB1
39.3HLA-DRB1, ITGAL
49.3HLA-DRB1, ITGAL
59.1IL13, TNF
6
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.1IL13, TNF
79.1IL13, TNF
89.1ITGAL, TNF
9
Show member pathways
9.1ITGAL, TNF
10
Show member pathways
Immune response CD16 signaling in NK cells60
9.1TNF, ITGAL
119.0TNF, HLA-DRB1
129.0TNF, HLA-DRB1
13
Show member pathways
8.6IL13, ITGAL, TNF
14
Show member pathways
8.6IL13, ITGAL, TNF
15
Show member pathways
8.6TNF, ITGAL, IL13
16
Show member pathways
8.5IL13, TNF, HLA-DRB1
17
Show member pathways
8.5IL13, TNF, HLA-DRB1
188.5IL13, TNF, HLA-DRB1
198.5HLA-DRB1, TNF, ITGAL
208.5HLA-DRB1, TNF, ITGAL
21
Show member pathways
8.0IL13, ITGAL, TNF, HLA-DRB1

Compounds for genes affiliated with Actinic Prurigo

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Compounds related to Actinic Prurigo according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1nickel44 2410.8ITGAL, IL13
2glatiramer acetate44 1110.8IL13, HLA-DRB1
3theophylline44 28 24 1112.7IL13, ITGAL
4alpha tocopherol449.6IL13, ITGAL
5efalizumab44 1110.6ITGAL, TNF
6mip 1alpha449.6TNF, IL13
7il-12449.6IL13, TNF
8indoleamine449.5IL13, TNF
9staurosporin449.5ITGAL, TNF
10groalpha449.5TNF, IL13
11leflunomide44 50 1111.5TNF, IL13
12gm-csf44 2810.5IL13, TNF
13budesonide44 50 1111.5TNF, IL13
14fluticasone propionate44 50 61 1112.5IL13, TNF
15rolipram44 61 2811.5IL13, TNF
16il 10449.5IL13, TNF
17tarc449.5TNF, IL13
18n-formylmethionyl-leucylphenylalanine449.5ITGAL, TNF
19pentoxifylline44 1110.5IL13, TNF
20ccl344 2810.5IL13, TNF
21gold sodium thiomalate449.5TNF, HLA-DRB1
22rituximab44 50 1111.4IL13, TNF
23cyclophosphamide44 50 1111.4IL13, ITGAL
24thalidomide44 50 61 1112.4IL13, TNF
25chloroquine44 2 50 28 1113.4ITGAL, TNF
26sp 60012544 6110.3IL13, TNF
27hyaluronic acid44 2410.3IL13, ITGAL
28allergens449.3IL13, ITGAL, HLA-DRB1
29hydrocortisone44 2 61 1112.2IL13, TNF
30tgf beta1449.2IL13, TNF
31simvastatin44 50 61 28 24 1114.1TNF, ITGAL
32mannose449.1IL13, ITGAL
33leukotriene b444 61 2411.1IL13, ITGAL, TNF
34prednisolone44 28 1111.1TNF, ITGAL, IL13
35endotoxin449.1IL13, ITGAL, TNF
36ionomycin449.1IL13, ITGAL, TNF
37fmlp449.1TNF, ITGAL, IL13
38glutamate449.0IL13, ITGAL, HLA-DRB1
39tacrolimus44 50 1111.0IL13, ITGAL, TNF
40calcitriol44 61 24 1112.0TNF, ITGAL, IL13
41rantes449.0IL13, ITGAL, TNF
42alanine449.0HLA-DRB1, ITGAL, IL13
43actinomycin d449.0TNF, ITGAL, IL13
44cyclosporin a44 28 6111.0TNF, ITGAL, IL13
45pge2449.0IL13, ITGAL, TNF
46cycloheximide449.0TNF, ITGAL, IL13
47h2o2449.0IL13, ITGAL, TNF
48dexamethasone44 50 28 1111.9TNF, ITGAL, IL13
49nitric oxide44 24 1110.9TNF, ITGAL, IL13
50retinoic acid44 249.8TNF, ITGAL, IL13

GO Terms for genes affiliated with Actinic Prurigo

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Cellular components related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL13, ITGAL, TNF, HLA-DRB1

Biological processes related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IL13, ITGAL
2positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, TNF
3inflammatory responseGO:0069548.5IL13, ITGAL, TNF

Molecular functions related to Actinic Prurigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL13, TNF

Products for genes affiliated with Actinic Prurigo

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Sources for Actinic Prurigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet