MCID: ACT164
MIFTS: 40

Actinic Prurigo malady

Categories: Genetic diseases, Skin diseases, Rare diseases

Aliases & Classifications for Actinic Prurigo

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Sources:
52Orphanet, 66UMLS, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Actinic Prurigo:

Name: Actinic Prurigo 52 66
Hereditary Polymorphous Light Eruption of American Indians 52
Familial Polymorphous Light Eruption of American Indians 52
 
Hutchinson Summer Prurigo 52
Hydroa Aestivale 52
Hydroa Estivale 66

Characteristics:

Orphanet epidemiological data:

52
actinic prurigo:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood

Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

Orphanet52 ORPHA330061
ICD10 via Orphanet29 L56.4

Summaries for Actinic Prurigo

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Wikipedia:69 Actinic prurigo (also known as \"Familial polymorphous light eruption of American Indians,\"... more...

MalaCards based summary: Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to lupus erythematosus and common variable immunodeficiency, and has symptoms including juvenile spring eruption An important gene associated with Actinic Prurigo is TNF (Tumor Necrosis Factor), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cellular roles of Anthrax toxin. Affiliated tissues include skin, b cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Related Diseases for Actinic Prurigo

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Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.5IL1B, SELE
2common variable immunodeficiency10.8HLA-DRB1, TNF
3parsonage turner syndrome10.8HLA-DRB1, TNF
4weber syndrome10.8HLA-DRB1, TNF
5myopathy-growth delay-intellectual disability-hypospadias syndrome10.8HLA-DRB1, TNF
6thyroid malformation10.8IL1B, TNF
7krieble bixler syndrome10.8HLA-DRB1, TNF
8hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.7IL1B, TNF
9epstein-barr virus hepatitis10.7HLA-DRB1, TNF
10abdominal chemodectomas with cutaneous angiolipomas10.7HLA-DRB1, TNF
11baetz-greenwalt syndrome10.7IL1B, TNF
12pulmonary hypertension10.7IL1B, TNF
13scrotum paget's disease10.7IL1B, TNF
14warm antibody hemolytic anemia10.7IL1B, TNF
15rheumatic myocarditis10.7CD58, HLA-DRB1
16cartilage disease10.7IL1B, TNF
17hypothyroidism10.7IL1B, TNF
18peri-anal fistula10.7HLA-DRB1, IL1B
19autoimmune polyendocrine syndrome10.7IL1B, TNF
20lymphocytic colitis10.7HLA-DRB1, TNF
21panuveitis10.6HLA-DRB1, TNF
22gonococcal synovitis10.6SELE, TNF
23ileocolitis10.6IL1B, TNF
24rectosigmoid junction neoplasm10.6IL1B, TNF
25scarlet fever10.6IL1B, TNF
26conventional leiomyosarcoma10.6HLA-DRB1, IL1B
27peripheral t-cell lymphoma10.6HLA-DRB1, TNF
28aortic arch interruption10.6IL13, TNF
29trichosporonosis10.6ITGAL, TNF
30hernia of ovary and fallopian tube10.6HLA-DRB1, TNF
31non-secretory myeloma10.6IL1B, TNF
32plantar nerve lesion10.6IL13, TNF
33amyotrophic lateral sclerosis type 410.5IL1B, TNF
34nephrosclerosis10.5HLA-DRB1, IL1B, TNF
35retroperitoneal fibrosis10.5HLA-DRB1, IL1B, TNF
36sternum lymphoma10.5HLA-DRB1, IL1B, TNF
37xanthomatosis10.5HLA-DRB1, IL1B, TNF
38adult malignant hemangiopericytoma10.5HLA-DRB1, IL1B, TNF
39purpura fulminans10.5HLA-DRB1, IL13
40indian tick typhus10.5IL13, SELE
41lethal midline granuloma10.5HLA-DRB1, IL1B, TNF
42autoimmune myocarditis10.5ICAM1, ITGAL
43ileitis10.5ICAM1, IL1B
44parasitic helminthiasis infectious disease10.5ICAM1, SELE
45brain stem angioblastoma10.5HLA-DRB1, IL1B, TNF
46ampulla of vater neoplasm10.4IL1B, SELE, TNF
47peripheral scars of retina10.4ICAM1, SELE
48macroglobulinemia10.4CD2, ICAM1
49ovary transitional cell carcinoma10.4HLA-DRB1, IL1B, TNF
50angioedema10.4ICAM1, TNF

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to actinic prurigo

Symptoms for Actinic Prurigo

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UMLS symptoms related to Actinic Prurigo:


juvenile spring eruption

Drugs & Therapeutics for Actinic Prurigo

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

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Anatomical Context for Actinic Prurigo

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MalaCards organs/tissues related to Actinic Prurigo:

34
Skin, B cells, Testes

Animal Models for Actinic Prurigo or affiliated genes

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MGI Mouse Phenotypes related to Actinic Prurigo:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.0CD69, ICAM1, IL13, IL1B, ITGA4, ITGAL
2MP:00053976.9CD69, ICAM1, IL13, IL1B, ITGA4, ITGAL

Publications for Actinic Prurigo

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Articles related to Actinic Prurigo:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01. (26787110)
2016
2
Actinic prurigo of the lip: Two case reports. (25133153)
2014
3
Determination of apoptosis in actinic prurigo by TUNEL technique. (25377923)
2014
4
Actinic prurigo. (24891055)
2014
5
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. (24177610)
2013
6
Chronic actinic prurigo presenting in an adopted child. (20199425)
2010
7
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. (19744180)
2009
8
Hypodontia in a patient with actinic prurigo: a case report. (19619430)
2009
9
Actinic prurigo. (18811871)
2008
10
Actinic prurigo deterioration due to degradation of DermaGard window film. (17553049)
2007
11
Adult-onset actinic prurigo in Thailand. (17986059)
2007
12
Actinic prurigo in an Albanian girl. (16445427)
2006
13
Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. (16606409)
2006
14
Immune responses to isolated human skin antigens in actinic prurigo. (16501416)
2006
15
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. (15569010)
2004
16
Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. (15118367)
2004
17
Diagnosis and treatment of actinic prurigo. (12919125)
2003
18
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. (11982570)
2002
19
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. (11531784)
2001
20
Long-term thalidomide for actinic prurigo. (11903163)
2001
21
Effectors of inflammation in actinic prurigo. (11369907)
2001
22
Caucasian actinic prurigo: 8 cases observed in France. (11167711)
2001
23
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). (10721864)
2000
24
A case of actinic prurigo in Thailand. (10692819)
2000
25
The conjunctivitis of solar (actinic) prurigo. (11123772)
2000
26
Major gene segregation of actinic prurigo among North American Indians in Saskatchewan. (10817657)
2000
27
An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. (9649710)
1998
28
Actinic prurigo: limited effect of PUVA. (9217842)
1997
29
Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. (9209891)
1997
30
Actinic prurigo. (9372522)
1997
31
Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. (9204058)
1997
32
Treatment of actinic prurigo in Chimila Indians. (8737876)
1996
33
HLA-DR4 may determine expression of actinic prurigo in British patients. (8601742)
1996
34
Actinic prurigo: an update. (7657433)
1995
35
Actinic prurigo. (8157403)
1994
36
Actinic prurigo. The possible etiologic role of an amino acid in the diet. (8231981)
1993
37
Histopathology of actinic prurigo. (8214390)
1993
38
Actinic prurigo, tropical (South-East Asian) variant. (1342193)
1992-1993
39
HLA typing in actinic prurigo. (1597562)
1992
40
Actinic prurigo among the Chimila Indians in Colombia: HLA studies. (2370330)
1990
41
Treatment of actinic prurigo with intermittent short-course topical 0.05% clobetasol 17-propionate. A preliminary report. (2396838)
1990
42
Actinic prurigo at sea level in Colombia. (2722335)
1989
43
Patch testing in actinic prurigo. (2598651)
1989
44
Human lymphocyte antigen in actinic prurigo. (3346416)
1988
45
Actinic prurigo of the lower lip. Review of the literature and report of five cases. (3281085)
1988
46
Thalidomide in actinic prurigo. (6838772)
1983
47
Actinic prurigo. (6629604)
1983
48
Actinic prurigo, a variety of polymorphous light eruption. (7095955)
1982
49
Actinic prurigo: clinical-pathological correlation. (730451)
1978
50
Thalidomide in the treatment of actinic prurigo. (4747626)
1973

Variations for Actinic Prurigo

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Expression for genes affiliated with Actinic Prurigo

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Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for genes affiliated with Actinic Prurigo

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Pathways related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL13, IL1B
29.5IL1B, TNF, VCAM1
3
Show member pathways
9.5IL13, IL1B, TNF
4
Show member pathways
9.5ICAM1, IL1B, TNF
59.5ICAM1, IL1B, TNF
69.4ICAM1, TNF, VCAM1
79.3ICAM1, SELE, VCAM1
89.3ICAM1, IL13, SELE
9
Show member pathways
9.2IL13, IL1B, ITGA4
109.2HLA-DRB1, IL13, IL1B, TNF
119.2CD2, IL13, IL1B, TNF
12
Show member pathways
9.1HLA-DRB1, IL1B, ITGA4, TNF
139.1HLA-DRB1, ICAM1, ITGAL
149.1ICAM1, ITGA4, VCAM1
159.1ICAM1, IL1B, TNF, VCAM1
169.1ICAM1, IL1B, TNF, VCAM1
179.0IL13, IL1B, ITGA4, TNF
18
Show member pathways
9.0CD2, ICAM1, IL13, IL1B
19
Show member pathways
9.0ITGA4, ITGAL, VCAM1
208.8CD58, HLA-DRB1, ICAM1, ITGAL
21
Show member pathways
8.8HLA-DRB1, ICAM1, IL13, IL1B, TNF
228.8CD2, HLA-DRB1, IL1B, ITGA4, TNF
238.8ICAM1, IL1B, SELE, TNF, VCAM1
248.8ICAM1, IL1B, SELE, TNF, VCAM1
258.8ICAM1, IL1B, SELE, TNF, VCAM1
268.7CD2, CD69, ITGAL, TNF
278.6HLA-DRB1, ICAM1, IL1B, ITGAL, TNF
28
Show member pathways
8.5ICAM1, ITGA4, ITGAL, VCAM1
298.5HLA-DRB1, ICAM1, ITGAL, TNF, VCAM1
30
Show member pathways
8.4CD2, CD58, ITGA4, ITGAL, SELE
318.2ICAM1, ITGA4, ITGAL, TNF, VCAM1
328.1ICAM1, IL1B, ITGAL, SELE, TNF, VCAM1
33
Show member pathways
8.0CD2, IL13, IL1B, ITGA4, ITGAL, TNF
34
Show member pathways
8.0CD2, IL13, IL1B, ITGA4, ITGAL, TNF
35
Show member pathways
7.7ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
367.7ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
377.7ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
38
Show member pathways
7.7ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
39
Show member pathways
7.6HLA-DRB1, ICAM1, IL13, IL1B, ITGA4, ITGAL
406.5CD2, CD58, HLA-DRB1, ICAM1, ICAM3, ITGA4
41
Show member pathways
6.4HLA-DRB1, ICAM1, ICAM3, IL13, IL1B, ITGA4

GO Terms for genes affiliated with Actinic Prurigo

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Cellular components related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6CD2, CD69, ICAM1, IL13, TNF, VCAM1
2extracellular spaceGO:00056158.6ICAM1, IL13, IL1B, SELE, TNF, VCAM1
3integral component of plasma membraneGO:00058877.8CD2, CD58, CD69, ICAM1, ICAM3, TNF
4cell surfaceGO:00099867.6CD2, CD58, HLA-DRB1, ICAM1, ITGA4, ITGAL
5extracellular exosomeGO:00700627.0CD58, HLA-DRB1, ICAM1, ICAM3, IL1B, ITGA4
6plasma membraneGO:00058865.9CD2, CD58, HLA-DRB1, ICAM1, ICAM3, ITGA4

Biological processes related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.6IL1B, TNF
3sequestering of triglycerideGO:003073010.6IL1B, TNF
4chronic inflammatory response to antigenic stimulusGO:000243910.6IL1B, TNF
5regulation of establishment of endothelial barrierGO:190314010.6IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.6IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL1B, TNF
9positive regulation of fever generationGO:003162210.5IL1B, TNF
10positive regulation of interleukin-8 secretionGO:200048410.5CD2, CD58
11negative regulation of lipid catabolic processGO:005099510.5IL1B, TNF
12regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
13membrane to membrane dockingGO:002261410.3ICAM1, VCAM1
14T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:000229110.1ICAM1, ITGAL
15interferon-gamma-mediated signaling pathwayGO:006033310.0HLA-DRB1, ICAM1, VCAM1
16heterotypic cell-cell adhesionGO:003411310.0CD2, CD58, ITGA4
17positive regulation of NF-kappaB transcription factor activityGO:00510929.8ICAM1, IL1B, TNF
18cellular response to tumor necrosis factorGO:00713569.8CD58, ICAM1, VCAM1
19positive regulation of nitric oxide biosynthetic processGO:00454299.8ICAM1, IL1B, TNF
20leukocyte tethering or rollingGO:00509019.7ITGA4, SELE, TNF, VCAM1
21receptor clusteringGO:00431139.6ITGA4, ITGAL
22cell-matrix adhesionGO:00071609.4ITGA4, ITGAL, VCAM1
23heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.2ICAM1, ITGAL, SELE, VCAM1
24response to ethanolGO:00454718.9ICAM1, IL13, IL1B, VCAM1
25inflammatory responseGO:00069548.9IL13, IL1B, ITGAL, SELE, TNF
26response to lipopolysaccharideGO:00324968.9ICAM1, IL13, IL1B, SELE, VCAM1
27leukocyte cell-cell adhesionGO:00071598.8ICAM1, ITGA4, ITGAL, SELE, VCAM1
28single organismal cell-cell adhesionGO:00163378.1CD2, CD58, ICAM1, ICAM3, ITGAL
29regulation of immune responseGO:00507768.1ICAM1, ICAM3, ITGA4, ITGAL, VCAM1
30cell adhesionGO:00071557.9CD58, ICAM1, ICAM3, ITGAL, VCAM1
31extracellular matrix organizationGO:00301987.7ICAM1, ICAM3, ITGA4, ITGAL, TNF, VCAM1
32leukocyte migrationGO:00509007.3CD2, CD58, ICAM1, IL1B, ITGA4, ITGAL

Molecular functions related to Actinic Prurigo according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:00508399.0ITGA4, ITGAL, VCAM1
2integrin bindingGO:00051788.5ICAM1, ICAM3, VCAM1

Sources for Actinic Prurigo

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet