MCID: ACT055
MIFTS: 43

Actinomycosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 72 49 55 41 14 69
Keratoactinomycosis 49 69
Actinomycetoma 12 69
Canaliculitis 49 69
Boil 12 72
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 49
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 49
Actinomycetes 49
Furuncle 69

Characteristics:

Orphanet epidemiological data:

55
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Actinomycosis

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

MalaCards based summary : Actinomycosis, also known as keratoactinomycosis, is related to chronic canaliculitis and acute canaliculitis. An important gene associated with Actinomycosis is TMEM79 (Transmembrane Protein 79). The drugs Ciclopirox and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and lung.

NIH Rare Diseases : 49 Actinomycosis is a chronic bacterial infection that commonly affects the face and neck. It is usually caused by an anaerobic bacteria called Actinomyces israelii. Actinomyces are normal inhabitants of the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection usually occurs in the face and neck, but can sometimes occur in the chest, abdomen, pelvis, or other areas of the body. The infection is not contagious. Last updated: 4/28/2011

Wikipedia : 72 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 chronic canaliculitis 12.1
2 acute canaliculitis 12.0
3 hidradenitis suppurativa 11.3
4 farmer's lung 11.3
5 mycetoma 11.2
6 bagassosis 11.2
7 carbuncle 11.2
8 olecranon bursitis 10.9
9 hordeolum 10.9
10 ventilation pneumonitis 10.9
11 mushroom workers' lung 10.9
12 biotin deficiency 10.9
13 diarrhea 10.9
14 cholera 10.9
15 perichondritis of auricle 10.9
16 prion disease 10.9
17 genetic prion diseases 10.9
18 hepatitis 10.3
19 esophagitis 10.1
20 lung cancer 10.0
21 mycobacterium chelonae 10.0
22 burns 10.0
23 mycobacterium tuberculosis 1 10.0
24 osteomyelitis 10.0
25 tonsillitis 10.0
26 nocardiosis 10.0
27 pancreatitis 10.0
28 episodic pain syndrome, familial, 1 9.9
29 hydronephrosis 9.9
30 cervicitis 9.9
31 laryngitis 9.9
32 appendicitis 9.9
33 lymphogranuloma venereum 9.9
34 cryptosporidiosis 9.9
35 egg allergy 9.9
36 impetigo 9.9
37 bullous pemphigoid 9.9
38 ovarian cancer 9.9
39 dry eye syndrome 9.9
40 plasmacytoma 9.9
41 conjunctivitis 9.9
42 dacryocystitis 9.9
43 mycobacterium fortuitum 9.9
44 pyogenic granuloma 9.9
45 pulmonary aspergilloma 9.8
46 nasopharyngitis 9.8
47 pneumonia 9.8
48 thyroiditis 9.8
49 lung disease 9.8
50 fibrosis of extraocular muscles, congenital, 1 9.8

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3 Anti-Infective Agents Phase 4,Phase 3,Phase 1
4 Antifungal Agents Phase 4
5
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
6
BCG vaccine Investigational Phase 3
7 Anti-Infective Agents, Local Phase 3,Phase 1
8 Antimetabolites Phase 3
9 Cariostatic Agents Phase 3
10 Fluorides Phase 3
11 Hypolipidemic Agents Phase 3
12 Lipid Regulating Agents Phase 3
13 Protective Agents Phase 3
14
Tin Phase 3 7440-31-5
15 Tin Fluorides Phase 3
16 Adjuvants, Immunologic Phase 3
17 Alkylating Agents Phase 3
18 Anti-Bacterial Agents Phase 3
19 Antibiotics, Antitubercular Phase 3
20 Mitomycins Phase 3
21 Nucleic Acid Synthesis Inhibitors Phase 3
22 Vaccines Phase 3
23
Chlorhexidine Approved, Vet_approved Phase 1 55-56-1 2713 9552079
24 Chlorhexidine gluconate Phase 1
25 Dermatologic Agents Phase 1
26 Disinfectants Phase 1
27
Menthol Approved 2216-51-5 16666
28 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children Terminated NCT01646580 Phase 4 ciclopirox
2 Investigate Oral Bacteria in Adult Population Completed NCT00762177 Phase 3 Fluoride;Fluoride, Triclosan;Stannous Fluoride
3 Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer Recruiting NCT02948543 Phase 3 Mitomycin C (MMC)
4 Chlorhexidine Gel Therapy for Cariogenic Oral Microflora Completed NCT01036412 Phase 1 1% Chlorhexidine Gluconate Gel
5 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
6 Oral Hygiene Intervention Pilot Study Active, not recruiting NCT02668809

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

38
Skin, Colon, Lung, Bone, Liver, Tonsil, Breast

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 661)
# Title Authors Year
1
Retraction: Thoracic Vertebral Actinomycosis Secondary to a Pulmonary Origin. ( 29383289 )
2018
2
Pulmonary actinomycosis masquerading as lung cancer: keep it in mind. ( 29423982 )
2018
3
Refractory actinomycosis of the humerus. ( 29348917 )
2018
4
A case of esophageal actinomycosis with a unique morphology presenting as a refractory ulcer. ( 29124648 )
2018
5
Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature. ( 28202870 )
2017
6
A bump in the groin: Cutaneous actinomycosis. ( 28932167 )
2017
7
Periorbital actinomycosis masquerading as a cutaneous malignancy. ( 29181765 )
2017
8
Pelvic actinomycosis fistulised to the skin, treated with doxycycline. ( 29446822 )
2017
9
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. ( 28720253 )
2017
10
Omental actinomycosis imitating a foreign body infection. ( 28709171 )
2017
11
Pulmonary Actinomycosis in a Patient with AIDS/HCV. ( 28764230 )
2017
12
A Complicated Thread: Abdominal Actinomycosis in a Young Woman with Crohn Disease. ( 28690491 )
2017
13
Actinomycosis Causing Recurrent Perianal Fistulae. ( 28670596 )
2017
14
Endobronchial actinomycosis associated with an inorganic foreign body. ( 28599808 )
2017
15
Nonhealing Wound at Wrist for 2 Years: Ultimately Proved to be Actinomycosis. ( 29263556 )
2017
16
Actinomycosis is not Frequent in the Periapex But is a Persistent Lesion. ( 29211122 )
2017
17
Thoracic Actinomycosis With Infiltration of the Spine: An Oncological Pitfall. ( 29240031 )
2017
18
Actinomycosis of the foot - A South African case. ( 28876622 )
2017
19
A rare case of subacute appendicitis, actinomycosis as the final pathology reports: A case report and literature review. ( 28531869 )
2017
20
Pulmonary actinomycosis masquerading as aspergilloma. ( 28473686 )
2017
21
Retroperitoneal Actinomycosis: A Rare Sequela of an Infected Obstructing Ureteral Stone. ( 28894842 )
2017
22
A rare coexistence of aspergillosis with actinomycosis. ( 28932040 )
2017
23
Pulmonary actinomycosis masquerading as lung cancer: A case report. ( 28889138 )
2017
24
A case of relapsed lung abscess caused by Eubacterium brachy infection following an initial diagnosis of pulmonary actinomycosis. ( 28856090 )
2017
25
Primary pulmonary actinomycosis: a retrospective analysis of 145 cases in mainland China. ( 28633709 )
2017
26
Pancreatic Head Actinomycosis. ( 28755735 )
2017
27
Pelvic Actinomycosis. ( 28684963 )
2017
28
Abdominal and pelvic actinomycosis due to longstanding intrauterine device: a slow and devastating infection. ( 28536687 )
2017
29
Actinomycosis presenting as an anterior abdominal mass after laparoscopic cholecystectomy. ( 28536234 )
2017
30
Osteoma with actinomycosis in a nasal cavity: A case report. ( 29390536 )
2017
31
Pericardial actinomycosis in a patient with oesophageal dysmotility and autoantibodies. ( 28783393 )
2017
32
IMAGES IN CLINICAL MEDICINE. Cutaneous Actinomycosis. ( 27144852 )
2016
33
Cervical vertebral actinomycosis mimicking malignancy in a paediatric patient. ( 27033296 )
2016
34
Primary Hepatic Actinomycosis Mimicking Hepatic Malignancy with Metastatic Lymph Nodes by F-18 FDG PET/CT. ( 26941867 )
2016
35
Thoracic Actinomycosis: A Rare Occurrence. ( 27103971 )
2016
36
Actinomycosis of the abdominal wall after cholecystectomy: transferral theory. ( 27966440 )
2016
37
Male Breast Abscess Secondary to Actinomycosis: A Case Report. ( 27190917 )
2016
38
The treatment of actinomycosis mimicking a retained root tip: a confusing case. ( 27595087 )
2016
39
Cytopathology of Hepatobiliary-Related Actinomycosis. ( 27199159 )
2016
40
Successful treatment of pelvic actinomycosis using transgluteal drainage: A case report. ( 26919913 )
2016
41
Pulmonary actinomycosis presenting as post-obstructive pneumonia. ( 27085876 )
2016
42
Actinomycosis arising from the nasal cavity, with rare fatal progression. ( 26860115 )
2016
43
Primary cutaneous actinomycosis over right gluteal region. ( 27294068 )
2016
44
A Case of Recalcitrant Actinomycosis Unresponsive to Antibiotic Therapy. ( 27832223 )
2016
45
Pulmonary actinomycosis masquerading as lung cancer: Case letter. ( 27578949 )
2016
46
Pulmonary actinomycosis: a rare case diagnosed on bronchoalveolar lavage cytology. ( 28028884 )
2016
47
Actinomycosis after allogeneic hematopoietic stem cell transplantation despite penicillin prophylaxis. ( 27203624 )
2016
48
Actinomycosis resembling liver tumor with multiple metastasis. ( 26948481 )
2016
49
Abdominal actinomycosis presenting as appendicitis: two case reports and review. ( 27147718 )
2016
50
Actinomyces meyeri, a Common Agent of Actinomycosis. ( 27432035 )
2016

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

GO Terms for Actinomycosis

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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