MCID: ACT150
MIFTS: 31

Acute Adrenal Insufficiency malady

Endocrine diseases category

Summaries for Acute Adrenal Insufficiency

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63Wikipedia, 32MalaCards
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Wikipedia:63 Adrenal crisis (also known as Addisonian crisis, Acute adrenal insufficiency) is a constellation of... more...

MalaCards: Acute Adrenal Insufficiency, also known as acute adrenocortical insufficiency, is related to addison's disease and thyroiditis. An important gene associated with Acute Adrenal Insufficiency is NR5A1 (nuclear receptor subfamily 5, group A, member 1), and among its related pathways are Insulin Processing and Glucocorticoid receptor regulatory network. The compounds metanephrine and prostaglandin have been mentioned in the context of this disorder. Related mouse phenotype cardiovascular system.

Aliases & Classifications for Acute Adrenal Insufficiency

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Sources:
48Orphanet, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
acute adrenocortical insufficiency:
Inheritance: Autosomal recessive,Sporadic,X-linked dominant; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute adrenal insufficiency 48
acute adrenocortical insufficiency 48
acute adrenal failure 48
addisonian crisis 60
adrenal crisis 48


External Ids:

ICD1025 E27.2

Related Diseases for Acute Adrenal Insufficiency

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Adrenal Insufficiency family:

acute adrenal insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1addison's disease30.3POMC, REN, CYP21A2, NR5A1
2thyroiditis30.2POMC
3adrenocortical carcinoma30.2CYP21A2, POMC, NR5A1
4hypothyroidism30.1POMC
5hypertension30.1REN, POMC
6cushing's syndrome30.1CYP21A2, REN, POMC
7diabetes insipidus30.0POMC
8graves' disease30.0CYP21A2
9hypopituitarism30.0POMC, CYP21A2
10adrenoleukodystrophy30.0REN, CYP21A2, NR5A1
11adrenal adenoma30.0CYP21A2, REN, POMC
12diabetes mellitus30.0POMC, IL6, REN
13congenital adrenal hyperplasia30.0REN, NR5A1, POMC, CYP21A2
14adenoma30.0CYP21A2, POMC, NR5A1, REN
15antiphospholipid syndrome10.4
16pneumonia10.3
17burns10.2
18adrenal carcinoma10.2
19thrombocytopenia10.2
20hypoglycemic coma10.2
21thyroid crisis10.2
22cardiac tamponade10.2
23pseudotumor cerebri10.2
24pituitary apoplexy10.2
25orchitis10.2
26pellagra10.2
27epididymo-orchitis10.2
28pericarditis10.2
29arthritis10.1
30acute pancreatitis10.1
31diabetic ketoacidosis10.1
32congenital adrenal insufficiency10.1
33appendicitis10.1
34waterhouse-friderichsen syndrome10.1
35acute cervicitis10.1
36acute myocardial infarction10.1
37asthma10.1
38cervicitis10.1
39eosinophilia10.1
40hepatitis10.1
41hyperglycemia10.1
42hyperparathyroidism10.1
43lung cancer10.1
44myocardial infarction10.1
45osteomyelitis10.1
46pancreatitis10.1
47renal cell carcinoma10.1
48thoracic cancer10.1
49thyrotoxicosis10.1
50tuberculosis10.1

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to acute adrenal insufficiency

Clinical Features for Acute Adrenal Insufficiency

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Drugs & Therapeutics for Acute Adrenal Insufficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Adrenal Insufficiency

Drug clinical trials:

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Search NIH Clinical Center for Acute Adrenal Insufficiency

Search CenterWatch for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

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Anatomical Context for Acute Adrenal Insufficiency

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Animal Models for Acute Adrenal Insufficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Adrenal Insufficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1IL6, REN, POMC, NR5A1

Publications for Acute Adrenal Insufficiency

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Genetic Variations for Acute Adrenal Insufficiency

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Expression for genes affiliated with Acute Adrenal Insufficiency

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for genes affiliated with Acute Adrenal Insufficiency

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Sources:
53Reactome, 37NCBI BioSystems Database
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Pathways related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3REN, POMC
29.0IL6, POMC

Compounds for genes affiliated with Acute Adrenal Insufficiency

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1metanephrine44 2410.8REN, CYP21A2
2prostaglandin449.8REN, NR5A1
3cortrosyn449.8CYP21A2, POMC
43beta-hydroxy-delta5-steroid449.8POMC, CYP21A2
5forskolin44 49 1111.7POMC, REN
618-hydroxycorticosterone44 2410.7REN, POMC
721-deoxycortisol44 2410.7POMC, CYP21A2
8ptx1449.7POMC, NR5A1
9nafarelin44 59 28 1112.7CYP21A2, POMC
10acth 1-24449.7POMC, CYP21A2
11cortisol28 2410.7CYP21A2, POMC
1217-hydroxypregnenolone449.6POMC, CYP21A2
13aminoglutethimide44 1110.6CYP21A2, POMC
1417beta-hydroxysteroid449.5CYP21A2, NR5A1
15cortisone44 2410.4CYP21A2, POMC
16metyrapone59 44 1111.4POMC, CYP21A2
173beta-hydroxysteroid449.3POMC, CYP21A2, NR5A1
18dehydroepiandrosterone sulfate449.3NR5A1, CYP21A2, POMC
19megestrol acetate449.3IL6, POMC
20dhea449.3NR5A1, POMC, CYP21A2
21fludrocortisone44 28 1111.3POMC, CYP21A2, REN
22doca449.3CYP21A2, POMC, REN
2311 deoxycortisol449.3POMC, REN, CYP21A2
2417-hydroxyprogesterone44 2410.2POMC, CYP21A2, REN
25spironolactone49 44 59 28 1113.2REN, CYP21A2, POMC
2611beta-hydroxysteroid449.2CYP21A2, REN, POMC
27desmopressin44 59 28 1112.2REN, POMC
28androstenedione44 2410.2REN, CYP21A2, POMC
29catecholamine449.2POMC, CYP21A2, REN
30carbenoxolone28 44 1111.1REN, IL6
31thyroxine44 2410.1REN, CYP21A2, POMC
32gnrh449.1CYP21A2, POMC, NR5A1
33ribonucleic acid449.1POMC, NR5A1, CYP21A2
34furosemide44 49 59 28 11 2414.0REN, POMC
35prednisolone44 28 1110.9POMC, IL6, CYP21A2
36corticosterone44 59 2410.8CYP21A2, POMC, NR5A1, REN
37estradiol44 11 2410.8CYP21A2, NR5A1, REN, POMC
38steroid448.7NR5A1, REN, POMC, CYP21A2
39indomethacin44 59 28 1111.7IL6, REN, POMC
40cholesterol44 28 11 2411.5REN, IL6, NR5A1, CYP21A2
41pge2448.5REN, IL6, POMC, NR5A1
42cycloheximide448.4NR5A1, POMC, CYP21A2, IL6
43hydrocortisone44 2 59 1111.4REN, POMC, IL6, CYP21A2
44epinephrine44 11 2410.4POMC, IL6, REN, CYP21A2
45testosterone44 59 11 2411.4POMC, NR5A1, CYP21A2, IL6
46norepinephrine44 11 2410.4IL6, REN, CYP21A2, POMC
47dexamethasone44 49 28 1111.3CYP21A2, IL6, POMC, REN
48estrogen448.3NR5A1, POMC, CYP21A2, IL6
49glucose448.2REN, IL6, POMC, CYP21A2
50acth448.0NR5A1, POMC, CYP21A2, REN, IL6

GO Terms for genes affiliated with Acute Adrenal Insufficiency

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16Gene Ontology
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Biological processes related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.2REN, POMC
2male gonad developmentGO:0085849.2REN, NR5A1
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.6IL6, POMC, NR5A1

Products for genes affiliated with Acute Adrenal Insufficiency

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  • Antibodies
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Sources for Acute Adrenal Insufficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet