MCID: ACT150
MIFTS: 48

Acute Adrenal Insufficiency malady

Genetic diseases, Endocrine diseases, Rare diseases, Reproductive diseases, Fetal diseases categories

Summaries for Acute Adrenal Insufficiency

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Wikipedia:64 Adrenal crisis (also known as Addisonian crisis, Acute adrenal insufficiency) is a constellation of... more...

MalaCards based summary: Acute Adrenal Insufficiency, also known as acute adrenal failure, is related to adrenocortical carcinoma and septic shock. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Corticotropin-releasing hormone and Metabolism of steroid hormones and vitamin D. The compounds 3beta-hydroxy-delta5-steroid and cortrosyn have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, liver and lung, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Acute Adrenal Insufficiency

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Sources:
48Orphanet, 61UMLS, 27ICD10 via Orphanet, 26ICD10
See all sources

Acute Adrenal Insufficiency, Aliases & Descriptions:

Name: Acute Adrenal Insufficiency 48 61
Acute Adrenal Failure 48 61
Adrenocortical Crisis 48 61
Addisonian Crisis 48 61
 
Adrenal Crisis 48 61
Adrenocortical Insufficiency, Acute 61
Acute Adrenocortical Insufficiency 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
acute adrenal insufficiency:
Inheritance: Autosomal recessive,Sporadic,X-linked dominant; Age of onset: Variable; Age of death: Any age


External Ids:

ICD10 via Orphanet27 E27.2
ICD1026 E27.2

Related Diseases for Acute Adrenal Insufficiency

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Diseases in the Congenital Adrenal Insufficiency family:

acute adrenal insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5NR5A1, POMC
2septic shock30.4POMC, IL6
3hypopituitarism30.4POMC, CYP21A2
4hypertension30.1POMC, REN
5cushing's syndrome30.0CYP21A2, POMC, REN
6addison's disease29.9CYP21A2, POMC, REN, NR5A1
7adrenoleukodystrophy29.8CYP21A2, REN, NR5A1
8diabetes mellitus29.8IL6, REN, POMC
9congenital adrenal hyperplasia29.5CYP21A2, POMC, REN, NR5A1
10adenoma29.5CYP21A2, POMC, REN, NR5A1
11adrenocortical insufficiency10.6
12antley-bixler syndrome10.4CYP21A2
13antiphospholipid syndrome10.4
14pneumonia10.4
15gonadal dysgenesis10.4NR5A1
16nephroblastoma10.3NR5A1
17thyroiditis10.3
18burns10.3
19spinal cord injury10.3
20thrombocytopenia10.3
21heparin-induced thrombocytopenia10.3
22hypoglycemic coma10.2
23adrenocorticotropic hormone deficiency10.2
24orchitis10.2
25cardiac tamponade10.2
26pituitary apoplexy10.2
27pellagra10.2
28epididymo-orchitis10.2
29pericarditis10.2
30adrenal gland hyperfunction10.2CYP21A2, POMC
31precocious puberty10.2POMC, CYP21A2
32arthritis10.2
33hyperandrogenism10.2CYP21A2, POMC
34adrenal rest tumor10.2NR5A1, CYP21A2
35skin disease10.2IL6, POMC
36hypospadias10.1CYP21A2, NR5A1
37gonadal disease10.1POMC, NR5A1
38klinefelter's syndrome10.1CYP21A2, NR5A1
39acute myocardial infarction10.1
40asthma10.1
41hepatitis10.1
42lymphedema10.1
43myocardial infarction10.1
44renal cell carcinoma10.1
45systemic lupus erythematosus10.1
46diabetic ketoacidosis10.1
47waterhouse-friderichsen syndrome10.1
48congenital adrenal insufficiency10.1
49appendicitis10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to acute adrenal insufficiency

Symptoms for Acute Adrenal Insufficiency

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Drugs & Therapeutics for Acute Adrenal Insufficiency

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Drug clinical trials:

Search ClinicalTrials for Acute Adrenal Insufficiency

Search NIH Clinical Center for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

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Anatomical Context for Acute Adrenal Insufficiency

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MalaCards organs/tissues related to Acute Adrenal Insufficiency:

32
Spinal cord, Liver, Lung, Adrenal gland, Testes

Animal Models for Acute Adrenal Insufficiency or affiliated genes

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MGI Mouse Phenotypes related to Acute Adrenal Insufficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3POMC, REN, IL6
2MP:00053858.1NR5A1, IL6, REN, POMC
3MP:00053868.1POMC, REN, IL6, NR5A1
4MP:00036318.0POMC, REN, IL6, NR5A1
5MP:00053768.0NR5A1, IL6, REN, POMC
6MP:00053787.9NR5A1, IL6, REN, POMC

Publications for Acute Adrenal Insufficiency

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Articles related to Acute Adrenal Insufficiency:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Systemic lupus erythematosus presenting as acute adrenal insufficiency: a rare clinical presentation. (24669348)
2014
2
Transient acute adrenal insufficiency associated with adenovirus serotype 40 infection. (24928932)
2014
3
Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male. (22970910)
2013
4
Acute adrenal insufficiency following arthroplasty: a case report and review of the literature. (24028157)
2013
5
Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome. (24251172)
2013
6
Acute adrenal insufficiency in cervical spinal cord injury. (22120347)
2012
7
Acute adrenal insufficiency in a neonate with bilateral adrenal hemorrhage and combined prothrombotic risk factors. (22652827)
2012
8
Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report. (19902248)
2010
9
Acute adrenal insufficiency in the newborn]. (16962294)
2006
10
Acute adrenal insufficiency. (17127145)
2006
11
Reversible acute adrenal insufficiency caused by fluconazole in a critically ill patient. (16954446)
2006
12
Images in cardiology: Acute adrenal insufficiency complicated by cardiogenic shock. (15772180)
2005
13
Atypical presentation of shock from acute adrenal insufficiency in an adolescent male. (15942517)
2005
14
Acute adrenal insufficiency presenting as high output ileostomy. (12648340)
2003
15
Acute adrenal insufficiency after cardiac surgery. (10708203)
2000
16
Acute adrenal insufficiency precipitated by isolated involvement of the adrenal gland by tuberculosis. (10714806)
1999
17
Bilateral adrenal hemorrhage resulting in acute adrenal insufficiency as an unusual complication of hepatic arterial chemoembolization. (9540911)
1998
18
Acute adrenal insufficiency following unilateral radical nephrectomy: a case report. (9893218)
1998
19
Acute adrenal insufficiency after coronary artery bypass grafting. (8893598)
1996
20
Acute adrenal insufficiency in critically ill liver transplant recipients. Implications for diagnosis. (7604447)
1995
21
Hemodynamic changes in acute adrenal insufficiency. (8201094)
1994
22
Acute adrenal insufficiency resulting from adrenal hemorrhage as indicated by post-operative hypotension. (8014290)
1994
23
Acute adrenal insufficiency in the patient with burns. (8501102)
1993
24
Acute adrenal insufficiency. (8325289)
1993
25
Acute adrenal insufficiency in the burn intensive care unit. (8435119)
1993
26
Acute adrenal insufficiency presenting as shock after trauma and surgery: three cases and review of the literature. (1732582)
1992
27
Acute adrenal insufficiency due to symptomatic Rathke's cleft cyst. (1633349)
1992
28
Acute adrenal insufficiency associated with high dose inhaled steroids. (1628017)
1992
29
Acute adrenal insufficiency secondary to heparin-induced thrombocytopenia-thrombosis syndrome. (1635495)
1992
30
Acute adrenal insufficiency as a manifestation of the anticardiolipin syndrome? (2730169)
1989
31
Diagnosis and therapy of acute adrenal insufficiency. (2771810)
1989
32
Acute adrenal insufficiency in extreme hyperglycemia. (3123590)
1988
33
Acute adrenal insufficiency as a complication of urological surgery. (3944871)
1986
34
Acute adrenal insufficiency in a patient with appendicitis during anesthesia. (2984963)
1985
35
CT of bilateral adrenal hemorrhage with acute adrenal insufficiency in the adult. (6607597)
1984
36
Acute adrenal insufficiency: recognition, management, and prevention. (6285575)
1982
37
Series on endocrine metabolic emergencies: II. Acute adrenal insufficiency. (6265530)
1981
38
Acute adrenal insufficiency following cardiac surgical procedures. (225607)
1979
39
Acute adrenal insufficiency. (209001)
1978
40
Letter: Simultaneous diagnosis and treatment of acute adrenal insufficiency. (55706)
1976
41
Acute adrenal insufficiency. (954383)
1976
42
Simultaneous investigation and treatment of suspected acute adrenal insufficiency. (52051)
1975
43
Acute adrenal insufficiency. (4213776)
1974
44
Acute adrenal insufficiency secondary to anticoagulant therapy. (5556205)
1971
45
Care of the critically ill child: acute adrenal insufficiency. (5795388)
1969
46
Acute adrenal insufficiency after steroid therapy in three asthmatics with pneumonia. (13834527)
1960
47
Acute adrenal insufficiency and acute myocardial infarction; simultaneous occurrence associated with marked eosinophilia and recovery. (13322213)
1956
48
Acute adrenal insufficiency. (13055543)
1953
49
Fulminating staphylococcemia with acute adrenal insufficiency. (13098462)
1953
50
Acute adrenal insufficiency after adrenalectomy for pre-pubertal virilism. (15406861)
1949

Variations for Acute Adrenal Insufficiency

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Expression for genes affiliated with Acute Adrenal Insufficiency

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Expression patterns in normal tissues for genes affiliated with Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for genes affiliated with Acute Adrenal Insufficiency

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Compounds for genes affiliated with Acute Adrenal Insufficiency

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Compounds related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
13beta-hydroxy-delta5-steroid449.9CYP21A2, POMC
2cortrosyn449.9CYP21A2, POMC
321-deoxycortisol44 2510.9CYP21A2, POMC
4nafarelin44 60 29 1212.8POMC, CYP21A2
5acth 1-24449.8POMC, CYP21A2
6cortisol29 2510.8POMC, CYP21A2
717-hydroxypregnenolone449.8POMC, CYP21A2
8aminoglutethimide44 1210.7POMC, CYP21A2
9megestrol acetate449.7POMC, IL6
10ptx1449.6NR5A1, POMC
11cortisone44 2510.6POMC, CYP21A2
12metyrapone44 60 1211.6POMC, CYP21A2
13metanephrine44 2510.6REN, CYP21A2
1418-hydroxycorticosterone44 2510.5POMC, REN
15prednisolone44 29 1211.3CYP21A2, POMC, IL6
163beta-hydroxysteroid449.3NR5A1, POMC, CYP21A2
17dehydroepiandrosterone sulfate449.3CYP21A2, POMC, NR5A1
18dhea449.3NR5A1, POMC, CYP21A2
19gnrh449.1NR5A1, POMC, CYP21A2
20carbenoxolone44 29 1211.1REN, IL6
21fludrocortisone44 29 1211.1CYP21A2, POMC, REN
22doca449.1CYP21A2, POMC, REN
2311 deoxycortisol449.1CYP21A2, POMC, REN
2417-hydroxyprogesterone44 2510.1CYP21A2, POMC, REN
25spironolactone44 60 29 50 1213.1REN, POMC, CYP21A2
2611beta-hydroxysteroid449.1REN, POMC, CYP21A2
27androstenedione44 2510.1CYP21A2, POMC, REN
28ribonucleic acid449.1CYP21A2, POMC, NR5A1
29catecholamine449.1REN, POMC, CYP21A2
30desmopressin44 60 29 1212.0REN, POMC
31thyroxine44 2510.0CYP21A2, POMC, REN
32furosemide44 60 29 50 25 1213.8REN, POMC
33prostaglandin448.8REN, IL6, NR5A1
34indomethacin44 29 60 1211.8IL6, REN, POMC
35cycloheximide448.7NR5A1, IL6, POMC, CYP21A2
36testosterone44 60 25 1211.7CYP21A2, POMC, IL6, NR5A1
37estrogen448.6CYP21A2, POMC, IL6, NR5A1
38hydrocortisone44 3 60 1211.6IL6, REN, POMC, CYP21A2
39epinephrine44 25 1210.6CYP21A2, POMC, REN, IL6
40norepinephrine44 25 1210.6CYP21A2, POMC, REN, IL6
41sodium44 259.6NR5A1, REN, CYP21A2
42corticosterone44 60 2510.5CYP21A2, POMC, REN, NR5A1
43dexamethasone44 50 29 1211.5IL6, REN, POMC, CYP21A2
44estradiol44 25 1210.5NR5A1, REN, POMC, CYP21A2
45forskolin44 50 1210.5CYP21A2, POMC, REN, NR5A1
46cholesterol44 29 25 1211.4NR5A1, IL6, REN, CYP21A2
47steroid448.4CYP21A2, POMC, REN, NR5A1
48pge2448.4POMC, REN, IL6, NR5A1
49glucose448.4IL6, REN, POMC, CYP21A2
50acth448.0NR5A1, IL6, REN, POMC, CYP21A2

GO Terms for genes affiliated with Acute Adrenal Insufficiency

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Cellular components related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6IL6, REN, POMC

Biological processes related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.1REN, POMC
2response to lipopolysaccharideGO:0324969.1IL6, REN
3male gonad developmentGO:0085848.9NR5A1, REN
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.5NR5A1, IL6, POMC

Products for genes affiliated with Acute Adrenal Insufficiency

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Sources for Acute Adrenal Insufficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet