MCID: ACT150
MIFTS: 48

Acute Adrenal Insufficiency malady

Genetic diseases, Endocrine diseases, Rare diseases, Reproductive diseases, Fetal diseases categories
Download this MalaCard

Summaries for Acute Adrenal Insufficiency

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Adrenal crisis (also known as Addisonian crisis, Acute adrenal insufficiency) is a constellation of... more...

MalaCards: Acute Adrenal Insufficiency, also known as addisonian crisis, is related to adrenocortical carcinoma and addison's disease. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Corticotropin-releasing hormone and Metabolism of steroid hormones and vitamin D. The compounds 3beta-hydroxy-delta5-steroid and cortrosyn have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, liver and lung, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Acute Adrenal Insufficiency

About this section
Sources:
49Orphanet, 62UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
addisonian crisis:
Inheritance: Autosomal recessive,Sporadic,X-linked dominant; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute adrenal insufficiency 49
addisonian crisis 49 62
acute adrenocortical insufficiency 49
acute adrenal failure 49
adrenocortical crisis 49
adrenal crisis 49


External Ids:

ICD10 via Orphanet26 E27.2
ICD1025 E27.2

Related Diseases for Acute Adrenal Insufficiency

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Congenital Adrenal Insufficiency family:

acute adrenal insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.3NR5A1, POMC
2addison's disease30.3NR5A1, REN, POMC, CYP21A2
3septic shock30.2IL6, POMC
4hypertension30.2POMC, REN
5hypopituitarism30.2POMC, CYP21A2
6cushing's syndrome30.1CYP21A2, POMC, REN
7adrenoleukodystrophy30.0CYP21A2, NR5A1, REN
8diabetes mellitus30.0POMC, REN, IL6
9congenital adrenal hyperplasia29.9REN, POMC, CYP21A2, NR5A1
10adenoma29.9NR5A1, CYP21A2, POMC, REN
11adrenocortical insufficiency10.6
12antiphospholipid syndrome10.4
13pneumonia10.4
14burns10.3
15thrombocytopenia10.3
16heparin-induced thrombocytopenia10.3
17spinal cord injury10.3
18hypoglycemic coma10.2
19thyroiditis10.2
20cardiac tamponade10.2
21pituitary apoplexy10.2
22orchitis10.2
23pellagra10.2
24pseudotumor cerebri10.2
25epididymo-orchitis10.2
26pericarditis10.2
27arthritis10.2
28diabetic ketoacidosis10.1
29appendicitis10.1
30waterhouse-friderichsen syndrome10.1
31congenital adrenal insufficiency10.1
32acute myocardial infarction10.1
33asthma10.1
34cervicitis10.1
35eosinophilia10.1
36hepatitis10.1
37hyperglycemia10.1
38hyperparathyroidism10.1
39hypothyroidism10.1
40lung cancer10.1
41myocardial infarction10.1
42osteomyelitis10.1
43pancreatitis10.1
44renal cell carcinoma10.1
45thyrotoxicosis10.1
46tuberculosis10.1
47castleman's disease10.1
48cardiogenic shock10.1
49antley-bixler syndrome10.1CYP21A2
50protein s deficiency10.1

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to acute adrenal insufficiency

Symptoms for Acute Adrenal Insufficiency

About this section

Drugs & Therapeutics for Acute Adrenal Insufficiency

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Acute Adrenal Insufficiency

Search NIH Clinical Center for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

About this section

Anatomical Context for Acute Adrenal Insufficiency

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Adrenal Insufficiency:

33
Spinal cord, Liver, Lung, Testes, Adrenal gland

Animal Models for Acute Adrenal Insufficiency or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Acute Adrenal Insufficiency:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3POMC, REN, IL6
2MP:00053858.1NR5A1, IL6, REN, POMC
3MP:00053868.1POMC, REN, IL6, NR5A1
4MP:00036318.0POMC, REN, IL6, NR5A1
5MP:00053768.0NR5A1, IL6, REN, POMC
6MP:00053787.9NR5A1, IL6, REN, POMC

Publications for Acute Adrenal Insufficiency

About this section
Sources:
52PubMed
See all sources

Articles related to Acute Adrenal Insufficiency:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male. (22970910)
2013
2
Acute adrenal insufficiency following arthroplasty: a case report and review of the literature. (24028157)
2013
3
Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome. (24251172)
2013
4
Acute adrenal insufficiency in cervical spinal cord injury. (22120347)
2012
5
Acute adrenal insufficiency in a neonate with bilateral adrenal hemorrhage and combined prothrombotic risk factors. (22652827)
2012
6
Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report. (19902248)
2010
7
Acute adrenal insufficiency associated with heparin-induced thrombocytopenia. (18575053)
2008
8
Acute adrenal insufficiency in the newborn]. (16962294)
2006
9
Acute adrenal insufficiency. (17127145)
2006
10
Reversible acute adrenal insufficiency caused by fluconazole in a critically ill patient. (16954446)
2006
11
Images in cardiology: Acute adrenal insufficiency complicated by cardiogenic shock. (15772180)
2005
12
Atypical presentation of shock from acute adrenal insufficiency in an adolescent male. (15942517)
2005
13
Acute adrenal insufficiency presenting as high output ileostomy. (12648340)
2003
14
Acute adrenal insufficiency after cardiac surgery. (10708203)
2000
15
Acute adrenal insufficiency precipitated by isolated involvement of the adrenal gland by tuberculosis. (10714806)
1999
16
Bilateral adrenal hemorrhage resulting in acute adrenal insufficiency as an unusual complication of hepatic arterial chemoembolization. (9540911)
1998
17
Acute adrenal insufficiency following unilateral radical nephrectomy: a case report. (9893218)
1998
18
Acute adrenal insufficiency after coronary artery bypass grafting. (8893598)
1996
19
Acute adrenal insufficiency in critically ill liver transplant recipients. Implications for diagnosis. (7604447)
1995
20
Hemodynamic changes in acute adrenal insufficiency. (8201094)
1994
21
Acute adrenal insufficiency resulting from adrenal hemorrhage as indicated by post-operative hypotension. (8014290)
1994
22
Acute adrenal insufficiency in the patient with burns. (8501102)
1993
23
Acute adrenal insufficiency. (8325289)
1993
24
Acute adrenal insufficiency in the burn intensive care unit. (8435119)
1993
25
Acute adrenal insufficiency presenting as shock after trauma and surgery: three cases and review of the literature. (1732582)
1992
26
Acute adrenal insufficiency due to symptomatic Rathke's cleft cyst. (1633349)
1992
27
Acute adrenal insufficiency associated with high dose inhaled steroids. (1628017)
1992
28
Acute adrenal insufficiency secondary to heparin-induced thrombocytopenia-thrombosis syndrome. (1635495)
1992
29
Acute adrenal insufficiency as a manifestation of the anticardiolipin syndrome? (2730169)
1989
30
Diagnosis and therapy of acute adrenal insufficiency. (2771810)
1989
31
Acute adrenal insufficiency and the antiphospholipid syndrome. (2817644)
1989
32
Acute adrenal insufficiency in extreme hyperglycemia. (3123590)
1988
33
Acute adrenal insufficiency as a complication of urological surgery. (3944871)
1986
34
Acute adrenal insufficiency in a patient with appendicitis during anesthesia. (2984963)
1985
35
CT of bilateral adrenal hemorrhage with acute adrenal insufficiency in the adult. (6607597)
1984
36
Acute adrenal insufficiency: recognition, management, and prevention. (6285575)
1982
37
Series on endocrine metabolic emergencies: II. Acute adrenal insufficiency. (6265530)
1981
38
Acute adrenal insufficiency following cardiac surgical procedures. (225607)
1979
39
Acute adrenal insufficiency. (209001)
1978
40
Letter: Simultaneous diagnosis and treatment of acute adrenal insufficiency. (55706)
1976
41
Acute adrenal insufficiency. (954383)
1976
42
Simultaneous investigation and treatment of suspected acute adrenal insufficiency. (52051)
1975
43
Acute adrenal insufficiency. (4213776)
1974
44
Acute adrenal insufficiency secondary to anticoagulant therapy. (5556205)
1971
45
Care of the critically ill child: acute adrenal insufficiency. (5795388)
1969
46
Acute adrenal insufficiency after steroid therapy in three asthmatics with pneumonia. (13834527)
1960
47
Acute adrenal insufficiency and acute myocardial infarction; simultaneous occurrence associated with marked eosinophilia and recovery. (13322213)
1956
48
Acute adrenal insufficiency. (13055543)
1953
49
Fulminating staphylococcemia with acute adrenal insufficiency. (13098462)
1953
50
Acute adrenal insufficiency after adrenalectomy for pre-pubertal virilism. (15406861)
1949

Variations for Acute Adrenal Insufficiency

About this section

Expression for genes affiliated with Acute Adrenal Insufficiency

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for genes affiliated with Acute Adrenal Insufficiency

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 60Thomson Reuters
See all sources

Compounds for genes affiliated with Acute Adrenal Insufficiency

About this section
Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB
See all sources

Compounds related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
13beta-hydroxy-delta5-steroid459.9CYP21A2, POMC
2cortrosyn459.9CYP21A2, POMC
321-deoxycortisol45 2410.9CYP21A2, POMC
4nafarelin45 61 29 1112.8POMC, CYP21A2
5acth 1-24459.8POMC, CYP21A2
6cortisol29 2410.8POMC, CYP21A2
717-hydroxypregnenolone459.8POMC, CYP21A2
8aminoglutethimide45 1110.7POMC, CYP21A2
9megestrol acetate459.7POMC, IL6
10ptx1459.6NR5A1, POMC
11cortisone45 2410.6POMC, CYP21A2
12metyrapone45 61 1111.6POMC, CYP21A2
13metanephrine45 2410.6REN, CYP21A2
1418-hydroxycorticosterone45 2410.5POMC, REN
15prednisolone45 29 1111.3CYP21A2, POMC, IL6
163beta-hydroxysteroid459.3NR5A1, POMC, CYP21A2
17dehydroepiandrosterone sulfate459.3CYP21A2, POMC, NR5A1
18dhea459.3NR5A1, POMC, CYP21A2
19gnrh459.1NR5A1, POMC, CYP21A2
20carbenoxolone45 29 1111.1REN, IL6
21fludrocortisone45 29 1111.1CYP21A2, POMC, REN
22doca459.1CYP21A2, POMC, REN
2311 deoxycortisol459.1CYP21A2, POMC, REN
2417-hydroxyprogesterone45 2410.1CYP21A2, POMC, REN
25spironolactone45 61 29 51 1113.1REN, POMC, CYP21A2
2611beta-hydroxysteroid459.1REN, POMC, CYP21A2
27androstenedione45 2410.1CYP21A2, POMC, REN
28ribonucleic acid459.1CYP21A2, POMC, NR5A1
29catecholamine459.1REN, POMC, CYP21A2
30desmopressin45 61 29 1112.0REN, POMC
31thyroxine45 2410.0CYP21A2, POMC, REN
32furosemide45 61 29 51 24 1113.8REN, POMC
33prostaglandin458.8REN, IL6, NR5A1
34indomethacin45 29 61 1111.8IL6, REN, POMC
35cycloheximide458.7NR5A1, IL6, POMC, CYP21A2
36testosterone45 61 24 1111.7CYP21A2, POMC, IL6, NR5A1
37estrogen458.6CYP21A2, POMC, IL6, NR5A1
38hydrocortisone45 3 61 1111.6IL6, REN, POMC, CYP21A2
39epinephrine45 24 1110.6CYP21A2, POMC, REN, IL6
40norepinephrine45 24 1110.6CYP21A2, POMC, REN, IL6
41sodium45 249.6NR5A1, REN, CYP21A2
42corticosterone45 61 2410.5CYP21A2, POMC, REN, NR5A1
43dexamethasone45 51 29 1111.5IL6, REN, POMC, CYP21A2
44estradiol45 24 1110.5NR5A1, REN, POMC, CYP21A2
45forskolin45 51 1110.5CYP21A2, POMC, REN, NR5A1
46cholesterol45 29 24 1111.4NR5A1, IL6, REN, CYP21A2
47steroid458.4CYP21A2, POMC, REN, NR5A1
48pge2458.4POMC, REN, IL6, NR5A1
49glucose458.4IL6, REN, POMC, CYP21A2
50acth458.0NR5A1, IL6, REN, POMC, CYP21A2

GO Terms for genes affiliated with Acute Adrenal Insufficiency

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6IL6, REN, POMC

Biological processes related to Acute Adrenal Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.1REN, POMC
2response to lipopolysaccharideGO:0324969.1IL6, REN
3male gonad developmentGO:0085848.9NR5A1, REN
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.5NR5A1, IL6, POMC

Products for genes affiliated with Acute Adrenal Insufficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Adrenal Insufficiency

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet