MCID: ACT150
MIFTS: 41

Acute Adrenal Insufficiency malady

Endocrine diseases, Rare diseases categories

Aliases & Classifications for Acute Adrenal Insufficiency

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Acute Adrenal Insufficiency, Aliases & Descriptions:

Name: Acute Adrenal Insufficiency 47
Addisonian Crisis 47 60
Acute Adrenocortical Insufficiency 47
 
Acute Adrenal Failure 47
Adrenocortical Crisis 47
Adrenal Crisis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
addisonian crisis:
Inheritance: Autosomal recessive,Not applicable,X-linked dominant; Age of onset: All ages; Age of death: any age


External Ids:

Orphanet47 95409
ICD10 via Orphanet26 E27.2
ICD1025 E27.2

Summaries for Acute Adrenal Insufficiency

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Wikipedia:63 Adrenal crisis (also known as Addisonian crisis, Acute adrenal insufficiency) is a medical emergency and... more...

MalaCards based summary: Acute Adrenal Insufficiency, also known as addisonian crisis, is related to adrenocortical carcinoma and hypopituitarism. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Corticotropin-releasing hormone and Metabolism of steroid hormones and vitamin D. The compounds 3beta-hydroxy-delta5-steroid and cortrosyn have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, spinal cord and liver, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Acute Adrenal Insufficiency

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Diseases in the Acute Adrenal Insufficiency family:

Congenital Adrenal Insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5NR5A1, POMC
2hypopituitarism30.4POMC, CYP21A2
3cushing's syndrome30.0CYP21A2, POMC, REN
4addison's disease29.9CYP21A2, POMC, REN, NR5A1
5adrenoleukodystrophy29.8CYP21A2, REN, NR5A1
6congenital adrenal hyperplasia29.5CYP21A2, POMC, REN, NR5A1
7adenoma29.5CYP21A2, POMC, REN, NR5A1
8antley-bixler syndrome10.4CYP21A2
9antiphospholipid syndrome10.4
10pneumonia10.4
11gonadal dysgenesis10.4NR5A1
12thyroiditis10.3
13burns10.3
14spinal cord injury10.3
15thrombocytopenia10.3
16heparin-induced thrombocytopenia10.3
17adrenocorticotropic hormone deficiency10.2
18hypoglycemic coma10.2
19pituitary apoplexy10.2
20orchitis10.2
21cardiac tamponade10.2
22pellagra10.2
23pseudotumor cerebri10.2
24epididymo-orchitis10.2
25pericarditis10.2
26oligomenorrhea10.2CYP21A2, POMC
27adrenal gland hyperfunction10.2CYP21A2, POMC
28precocious puberty10.2POMC, CYP21A2
29arthritis10.2
30adrenal rest tumor10.2NR5A1, CYP21A2
31hyperandrogenism10.2CYP21A2, POMC
32skin disease10.1IL6, POMC
33gonadal disease10.1POMC, NR5A1
34hypospadias10.1CYP21A2, NR5A1
35systemic lupus erythematosus10.1
36asthma10.1
37myocardial infarction10.1
38lung cancer10.1
39renal cell carcinoma10.1
40adrenal insufficiency, congenital, with 46xy sex reversal, partial or complete10.1
41acute myocardial infarction10.1
42lymphedema10.1
43diabetic ketoacidosis10.1
44appendicitis10.1
45waterhouse-friderichsen syndrome10.1
46cervicitis10.1
47eosinophilia10.1
48hyperglycemia10.1
49hyperparathyroidism10.1
50hypothyroidism10.1

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to acute adrenal insufficiency

Symptoms for Acute Adrenal Insufficiency

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Drugs & Therapeutics for Acute Adrenal Insufficiency

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Drug clinical trials:

Search ClinicalTrials for Acute Adrenal Insufficiency

Search NIH Clinical Center for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

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Anatomical Context for Acute Adrenal Insufficiency

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MalaCards organs/tissues related to Acute Adrenal Insufficiency:

31
Adrenal gland, Spinal cord, Liver, Lung, Testes

Animal Models for Acute Adrenal Insufficiency or affiliated genes

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MGI Mouse Phenotypes related to Acute Adrenal Insufficiency:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3POMC, REN, IL6
2MP:00053858.1NR5A1, IL6, REN, POMC
3MP:00053868.1POMC, REN, IL6, NR5A1
4MP:00036318.0POMC, REN, IL6, NR5A1
5MP:00053768.0NR5A1, IL6, REN, POMC
6MP:00053787.9NR5A1, IL6, REN, POMC

Publications for Acute Adrenal Insufficiency

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Articles related to Acute Adrenal Insufficiency:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Systemic lupus erythematosus presenting as acute adrenal insufficiency: a rare clinical presentation. (24669348)
2014
2
Transient acute adrenal insufficiency associated with adenovirus serotype 40 infection. (24928932)
2014
3
Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male. (22970910)
2013
4
Acute adrenal insufficiency following arthroplasty: a case report and review of the literature. (24028157)
2013
5
Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome. (24251172)
2013
6
Acute adrenal insufficiency in cervical spinal cord injury. (22120347)
2012
7
Acute adrenal insufficiency in a neonate with bilateral adrenal hemorrhage and combined prothrombotic risk factors. (22652827)
2012
8
Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report. (19902248)
2010
9
Acute adrenal insufficiency associated with heparin-induced thrombocytopenia. (18575053)
2008
10
Acute adrenal insufficiency in the newborn]. (16962294)
2006
11
Acute adrenal insufficiency. (17127145)
2006
12
Reversible acute adrenal insufficiency caused by fluconazole in a critically ill patient. (16954446)
2006
13
Images in cardiology: Acute adrenal insufficiency complicated by cardiogenic shock. (15772180)
2005
14
Atypical presentation of shock from acute adrenal insufficiency in an adolescent male. (15942517)
2005
15
Acute adrenal insufficiency presenting as high output ileostomy. (12648340)
2003
16
Acute adrenal insufficiency after cardiac surgery. (10708203)
2000
17
Acute adrenal insufficiency following unilateral radical nephrectomy: a case report. (9893218)
1998
18
Acute adrenal insufficiency after coronary artery bypass grafting. (8893598)
1996
19
Acute adrenal insufficiency in critically ill liver transplant recipients. Implications for diagnosis. (7604447)
1995
20
Hemodynamic changes in acute adrenal insufficiency. (8201094)
1994
21
Acute adrenal insufficiency resulting from adrenal hemorrhage as indicated by post-operative hypotension. (8014290)
1994
22
Acute adrenal insufficiency in the patient with burns. (8501102)
1993
23
Acute adrenal insufficiency. (8325289)
1993
24
Acute adrenal insufficiency in the burn intensive care unit. (8435119)
1993
25
Acute adrenal insufficiency presenting as shock after trauma and surgery: three cases and review of the literature. (1732582)
1992
26
Acute adrenal insufficiency due to symptomatic Rathke's cleft cyst. (1633349)
1992
27
Acute adrenal insufficiency associated with high dose inhaled steroids. (1628017)
1992
28
Acute adrenal insufficiency secondary to heparin-induced thrombocytopenia-thrombosis syndrome. (1635495)
1992
29
Acute adrenal insufficiency as a manifestation of the anticardiolipin syndrome? (2730169)
1989
30
Diagnosis and therapy of acute adrenal insufficiency. (2771810)
1989
31
Acute adrenal insufficiency and the antiphospholipid syndrome. (2817644)
1989
32
Acute adrenal insufficiency in extreme hyperglycemia. (3123590)
1988
33
Acute adrenal insufficiency as a complication of urological surgery. (3944871)
1986
34
Acute adrenal insufficiency in a patient with appendicitis during anesthesia. (2984963)
1985
35
CT of bilateral adrenal hemorrhage with acute adrenal insufficiency in the adult. (6607597)
1984
36
Acute adrenal insufficiency: recognition, management, and prevention. (6285575)
1982
37
Series on endocrine metabolic emergencies: II. Acute adrenal insufficiency. (6265530)
1981
38
Acute adrenal insufficiency following cardiac surgical procedures. (225607)
1979
39
Acute adrenal insufficiency. (209001)
1978
40
Letter: Simultaneous diagnosis and treatment of acute adrenal insufficiency. (55706)
1976
41
Acute adrenal insufficiency. (954383)
1976
42
Simultaneous investigation and treatment of suspected acute adrenal insufficiency. (52051)
1975
43
Acute adrenal insufficiency. (4213776)
1974
44
Acute adrenal insufficiency secondary to anticoagulant therapy. (5556205)
1971
45
Care of the critically ill child: acute adrenal insufficiency. (5795388)
1969
46
Acute adrenal insufficiency after steroid therapy in three asthmatics with pneumonia. (13834527)
1960
47
Acute adrenal insufficiency and acute myocardial infarction; simultaneous occurrence associated with marked eosinophilia and recovery. (13322213)
1956
48
Acute adrenal insufficiency. (13055543)
1953
49
Fulminating staphylococcemia with acute adrenal insufficiency. (13098462)
1953
50
Acute adrenal insufficiency after adrenalectomy for pre-pubertal virilism. (15406861)
1949

Variations for Acute Adrenal Insufficiency

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Expression for genes affiliated with Acute Adrenal Insufficiency

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Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for genes affiliated with Acute Adrenal Insufficiency

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Compounds for genes affiliated with Acute Adrenal Insufficiency

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Compounds related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
13beta-hydroxy-delta5-steroid439.9CYP21A2, POMC
2cortrosyn439.9CYP21A2, POMC
321-deoxycortisol43 2410.9CYP21A2, POMC
4nafarelin43 59 28 1212.8POMC, CYP21A2
5acth 1-24439.8POMC, CYP21A2
6cortisol28 2410.8POMC, CYP21A2
717-hydroxypregnenolone439.8POMC, CYP21A2
8aminoglutethimide43 1210.7POMC, CYP21A2
9megestrol acetate439.7POMC, IL6
10ptx1439.6NR5A1, POMC
11cortisone43 2410.6POMC, CYP21A2
12metyrapone43 59 1211.6POMC, CYP21A2
13metanephrine43 2410.6REN, CYP21A2
1418-hydroxycorticosterone43 2410.5POMC, REN
15prednisolone43 28 1211.3CYP21A2, POMC, IL6
163beta-hydroxysteroid439.3NR5A1, POMC, CYP21A2
17dehydroepiandrosterone sulfate439.3CYP21A2, POMC, NR5A1
18dhea439.3NR5A1, POMC, CYP21A2
19gnrh439.1NR5A1, POMC, CYP21A2
20carbenoxolone43 28 1211.1REN, IL6
21fludrocortisone43 28 1211.1CYP21A2, POMC, REN
22doca439.1CYP21A2, POMC, REN
2311 deoxycortisol439.1CYP21A2, POMC, REN
2417-hydroxyprogesterone43 2410.1CYP21A2, POMC, REN
25spironolactone43 59 28 49 1213.1REN, POMC, CYP21A2
2611beta-hydroxysteroid439.1REN, POMC, CYP21A2
27androstenedione43 2410.1CYP21A2, POMC, REN
28ribonucleic acid439.1CYP21A2, POMC, NR5A1
29catecholamine439.1REN, POMC, CYP21A2
30desmopressin43 59 28 1212.0REN, POMC
31thyroxine43 2410.0CYP21A2, POMC, REN
32furosemide43 59 28 49 24 1213.8REN, POMC
33prostaglandin438.8REN, IL6, NR5A1
34indomethacin43 28 59 1211.8IL6, REN, POMC
35cycloheximide438.7NR5A1, IL6, POMC, CYP21A2
36testosterone43 59 24 1211.7CYP21A2, POMC, IL6, NR5A1
37estrogen438.6CYP21A2, POMC, IL6, NR5A1
38hydrocortisone43 2 59 1211.6IL6, REN, POMC, CYP21A2
39epinephrine43 24 1210.6CYP21A2, POMC, REN, IL6
40norepinephrine43 24 1210.6CYP21A2, POMC, REN, IL6
41sodium43 249.6NR5A1, REN, CYP21A2
42corticosterone43 59 2410.5CYP21A2, POMC, REN, NR5A1
43dexamethasone43 49 28 1211.5IL6, REN, POMC, CYP21A2
44estradiol43 24 1210.5NR5A1, REN, POMC, CYP21A2
45forskolin43 49 1210.5CYP21A2, POMC, REN, NR5A1
46cholesterol43 28 24 1211.4NR5A1, IL6, REN, CYP21A2
47steroid438.4CYP21A2, POMC, REN, NR5A1
48pge2438.4POMC, REN, IL6, NR5A1
49glucose438.4IL6, REN, POMC, CYP21A2
50acth438.0NR5A1, IL6, REN, POMC, CYP21A2

GO Terms for genes affiliated with Acute Adrenal Insufficiency

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Cellular components related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.6IL6, REN, POMC

Biological processes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00082179.1REN, POMC
2response to lipopolysaccharideGO:00324969.1IL6, REN
3male gonad developmentGO:00085848.9NR5A1, REN
4positive regulation of transcription from RNA polymerase II promoterGO:00459448.5NR5A1, IL6, POMC

Products for genes affiliated with Acute Adrenal Insufficiency

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Sources for Acute Adrenal Insufficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet