MCID: ACT177
MIFTS: 29

Acute Basophilic Leukemia malady

Blood diseases, Cancer diseases categories

Summaries for Acute Basophilic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards: Acute Basophilic Leukemia is related to acute leukemia and leukemia. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and C-MYB transcription factor network. The drug thioguanine and the compounds Sargramostim and nitroblue tetrazolium have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Acute Basophilic Leukemia

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48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

acute basophilic leukemia 48 60


External Ids:

MESH via Orphanet35 D015471
ICD10 via Orphanet26 C94.7
SNOMED-CT via Orphanet57 69077002
UMLS via Orphanet61 C0023437

Related Diseases for Acute Basophilic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2IL3RA, MPO, IL18R1, ETV6, GATA1, CSF3
2leukemia31.2MYB, CSF2RA, IL3RA, GATA1, ETV6, MPO
3hodgkin's lymphoma30.2IL18R1, IL3RA, CSF3
4mast-cell leukemia10.2
5histiocytosis10.2
6langerhans-cell histiocytosis10.2
7myelofibrosis10.0GATA1
8monocytic leukemia10.0GATA1
9alpha thalassemia10.0GATA1
10pulmonary alveolar proteinosis10.0CSF2RA
11viral hepatitis10.0MYB
12vasculitis10.0MPO
13prostate cancer10.0IL18R1, CSF2RA
14multiple sclerosis10.0IL18R1
15splenomegaly10.0CSF3
16asthma10.0MPO, IL18R1
17megakaryocytic leukemia10.0GATA1, MPO
18leukemoid reaction10.0CSF3, GATA1
19hepatitis c10.0MYB
20neutropenia10.0CSF3, MPO
21aplastic anemia10.0CSF3, GATA1
22sarcoma10.0ETV6, IL18R1
23glioblastoma multiforme10.0MYB, IL18R1
24acute myelomonocytic leukemia10.0MPO, ETV6
25wilms tumor10.0GATA1, IL18R1, MYB
26deficiency anemia10.0CSF3, MYB, GATA1
27precursor b-cell acute lymphoblastic leukemia10.0MPO, ETV6
28thrombocytopenia10.0CSF3, GATA1, MYB
29fibrosarcoma10.0ETV6, MYB
30chronic lymphocytic leukemia10.0CSF2RA, MYB, IL18R1, IL3RA
31eosinophilia10.0MPO, ETV6, IL3RA
32sepsis10.0MPO, IL18R1, CSF3
33hematologic cancer10.0CSF3, IL3RA, ETV6
34chronic myelomonocytic leukemia10.0ETV6, MPO, CSF3
35non-hodgkin lymphoma10.0ETV6, MYB, CSF3
36myelodysplastic syndromes10.0MPO, GATA1, CSF3, ETV6
37burkitt's lymphoma10.0IL3RA, CSF3, MYB, ETV6
38precursor t-cell acute lymphoblastic leukemia10.0GATA1, IL18R1, MPO, ETV6, MYB
39myeloproliferative disorder10.0CSF3, GATA1, IL18R1, MPO, ETV6
40breast cancer10.0IL18R1, MYB, CSF3, IL3RA, ETV6
41chronic myeloid leukemia9.9MYB, CSF2RA, MPO, GATA1, CSF3, ETV6
42acute lymphocytic leukemia9.9GATA1, MYB, CSF3, MPO, ETV6, IL18R1
43myeloid leukemia9.9MPO, ETV6, IL3RA, IL18R1, MYB, GATA1

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Clinical Features for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Basophilic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Search CenterWatch for Acute Basophilic Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Basophilic Leukemia:

32
Myeloid

Animal Models for Acute Basophilic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9ETV6, MYB, MPO, GATA1, CSF3
2MP:00053877.1IL18R1, CSF3, GATA1, MPO, MYB, ETV6

Publications for Acute Basophilic Leukemia

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Genetic Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Acute Basophilic Leukemia

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Sources:
11DrugBank, 44Novoseek, 2BitterDB, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1Sargramostim119.8CSF2RA, IL3RA
2nitroblue tetrazolium449.5MYB, CSF3
3vesnarinone449.5CSF3, IL18R1
4alpha-naphthyl butyrate449.5CSF3, MPO
5chloramphenicol44 2 1111.5GATA1, MPO, MYB
6filgrastim44 1110.5IL18R1, CSF3
7propylthiouracil44 2 1111.4CSF3, MPO
8butyrate449.4GATA1, MPO, MYB
9gm-csf44 2810.4CSF3, CSF2RA
10aclarubicin449.3MYB, GATA1, CSF3
11methimazole44 2 1111.2CSF3, MPO
12methylcellulose449.2CSF3, MYB
13mitoxantrone44 49 1111.1MPO, CSF3
14cytarabine44 49 1111.1CSF3, GATA1, MPO
15imatinib44 49 1111.0ETV6, MYB, CSF3
1612-o-tetradecanoylphorbol 13-acetate449.0IL3RA, IL18R1, MYB, GATA1
17clozapine44 28 49 1112.0IL18R1, MPO, CSF3
18doxorubicin44 49 1111.0MYB, GATA1, CSF3
19zinc44 249.9IL3RA, IL18R1, MYB, GATA1
20n-formylmethionyl-leucylphenylalanine448.8MPO, CSF3
21cyclosporin a44 28 5910.8IL18R1, MYB, CSF3
22dmso448.8CSF3, GATA1, MPO, MYB
23serine448.6CSF2RA, GATA1, MPO, MYB, IL18R1
24gp 130448.5CSF2RA, CSF3, IL18R1, IL3RA
25prednisolone44 28 1110.5IL18R1, ETV6, MPO, CSF3
26thymidine44 249.5IL3RA, IL18R1, MYB, CSF3
27vegf447.8CSF3, GATA1, MPO, MYB, ETV6, IL18R1
28retinoic acid44 248.8CSF3, GATA1, MPO, MYB, ETV6, IL18R1
29tyrosine447.6CSF2RA, CSF3, MYB, ETV6, IL18R1, IL3RA

GO Terms for genes affiliated with Acute Basophilic Leukemia

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16Gene Ontology
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Molecular functions related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.2MYB, MPO, GATA1

Products for genes affiliated with Acute Basophilic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Basophilic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet