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MCID: ACT177
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Acute Basophilic Leukemia malady

Blood, Cancer categories
1 drug, 8 genes, 5 tissues, 44 related diseases, clinical trials.

Summaries for Acute Basophilic Leukemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards: Acute Basophilic Leukemia is related to acute leukemia and acute t cell leukemia. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and C-MYB transcription factor network. The drug thioguanine and the compounds Sargramostim and nitroblue tetrazolium have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, liver and myeloid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Acute Basophilic Leukemia

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Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood
ICD10: 26


Aliases & Descriptions:

acute basophilic leukemia 49 61


External Ids:

MESH via Orphanet36 D015471
ICD10 via Orphanet26 C94.7
SNOMED-CT via Orphanet58 69077002
UMLS via Orphanet62 C0023437

Related Diseases for Acute Basophilic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2CSF3, GATA1, MPO, MYB, ETV6, IL18R1
2acute t cell leukemia10.2
3mast-cell leukemia10.2
4t-cell leukemia10.2
5leukemia, acute pre-b-cell10.2
6myelofibrosis10.0GATA1
7monocytic leukemia10.0GATA1
8thalassemia10.0GATA1
9pulmonary alveolar proteinosis10.0CSF2RA
10viral hepatitis10.0MYB
11vasculitis10.0MPO
12prostate cancer10.0IL18R1, CSF2RA
13multiple sclerosis10.0IL18R1
14splenomegaly10.0CSF3
15asthma10.0IL18R1, MPO
16megakaryocytic leukemia10.0MPO, GATA1
17leukemoid reaction10.0CSF3, GATA1
18hepatitis c10.0MYB
19neutropenia10.0MPO, CSF3
20aplastic anemia10.0GATA1, CSF3
21sarcoma10.0IL18R1, ETV6
22glioblastoma multiforme10.0IL18R1, MYB
23acute myelomonocytic leukemia10.0MPO, ETV6
24wilms tumor10.0IL18R1, MYB, GATA1
25hodgkin's lymphoma10.0IL3RA, IL18R1, CSF3
26deficiency anemia10.0MYB, GATA1, CSF3
27precursor b-cell acute lymphoblastic leukemia10.0ETV6, MPO
28thrombocytopenia10.0CSF3, GATA1, MYB
29fibrosarcoma10.0MYB, ETV6
30chronic lymphocytic leukemia10.0CSF2RA, MYB, IL18R1, IL3RA
31eosinophilia10.0MPO, ETV6, IL3RA
32sepsis10.0CSF3, MPO, IL18R1
33hematologic cancer10.0CSF3, ETV6, IL3RA
34chronic myelomonocytic leukemia10.0CSF3, MPO, ETV6
35non-hodgkin lymphoma10.0ETV6, MYB, CSF3
36myelodysplastic syndromes10.0CSF3, GATA1, MPO, ETV6
37burkitt's lymphoma10.0CSF3, MYB, ETV6, IL3RA
38precursor t-cell acute lymphoblastic leukemia10.0GATA1, MPO, MYB, ETV6, IL18R1
39myeloproliferative disorder10.0CSF3, GATA1, MPO, ETV6, IL18R1
40breast cancer10.0CSF3, MYB, ETV6, IL18R1, IL3RA
41chronic myeloid leukemia9.9CSF2RA, CSF3, GATA1, MPO, MYB, ETV6
42acute lymphocytic leukemia9.9IL3RA, IL18R1, ETV6, MYB, MPO, GATA1
43myeloid leukemia9.9CSF3, GATA1, MPO, MYB, ETV6, IL18R1
44leukemia9.9CSF2RA, CSF3, GATA1, MPO, MYB, ETV6

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Clinical Features for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Acute Basophilic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Search CenterWatch for Acute Basophilic Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Acute Basophilic Leukemia:

33
Bone marrow, Liver, Myeloid, Monocytes, T cells

Animal Models for Acute Basophilic Leukemia or affiliated genes

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Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
hematopoietic system phenotype
MP:00053977.9ETV6, MYB, MPO, GATA1, CSF3
2
immune system phenotype
MP:00053877.1IL18R1, CSF3, GATA1, MPO, MYB, ETV6

Publications for Acute Basophilic Leukemia

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51PubMed
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Articles related to Acute Basophilic Leukemia:

(show all 27)
idTitleAuthorsYear
1
Unusual blasts with basophilic granules in 2 cases of de novo acute myeloid leukemia with inv3(q21q26.2) and monosomy 7 and coexpression of CD2 and CD31. (23896391)
2014
2
Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)
2013
3
A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)
2013
4
Acute basophilic leukemia in an infant with proptosis. (21393925)
2011
5
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)
2011
6
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)
2011
7
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)
2011
8
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
2008
9
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)
2007
10
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)
2006
11
Acute basophilic leukemia with t(8;21). (15160925)
2004
12
Acute basophilic leukemia: case report. (15164378)
2004
13
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)
2002
14
Acute basophilic leukemia. (11722593)
2001
15
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)
2000
16
Diagnosis of acute basophilic leukemia. (10037024)
1999
17
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)
1995
18
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)
1995
19
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)
1993
20
Acute basophilic leukemia. (1489389)
1992
21
Acute basophilic leukemia. A case report. (1718580)
1991
22
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)
1991
23
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)
1991
24
Evidence for the neoplastic involvement of monocytic, eosinophilic and basophilic lineages in acute myelomonocytic leukemia with eosinophilia. (2109454)
1990
25
Acute basophilic leukemia. (6731465)
1984
26
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
27
Follow-up of sixty two cases of acute basophilic leukemia. (667277)
1978

Genetic Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG, 52QIAGEN
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Pathways related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Notch-mediated HES/HEY network38
9.8GATA1, MYB
2
C-MYB transcription factor network38
9.2MYB, MPO, GATA1
3
Lymphocyte Signaling4
9.2MYB, MPO, GATA1
4
PI3K-Akt signaling pathway30
8.7IL3RA, MYB, CSF3
5
Jak-STAT signaling pathway30
8.6CSF2RA, CSF3, IL3RA
6
Hematopoietic cell lineage30
8.6IL3RA, CSF3, CSF2RA
7
Akt Signaling52
Hide members
8.2CSF2RA, CSF3, IL18R1, IL3RA
8
PAK Pathway52
Hide members
8.2CSF2RA, CSF3, IL18R1, IL3RA
9
Rho Family GTPases52
Hide members
8.2IL3RA, IL18R1, CSF3, CSF2RA
10
PEDF Induced Signaling52
Hide members
8.2IL3RA, IL18R1, CSF3, CSF2RA

Compounds for genes affiliated with Acute Basophilic Leukemia

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11DrugBank, 45Novoseek, 2BitterDB, 29IUPHAR, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1Sargramostim119.8CSF2RA, IL3RA
2nitroblue tetrazolium459.5MYB, CSF3
3vesnarinone459.5CSF3, IL18R1
4alpha-naphthyl butyrate459.5CSF3, MPO
5chloramphenicol45 2 1111.5GATA1, MPO, MYB
6filgrastim45 1110.5IL18R1, CSF3
7propylthiouracil45 2 1111.4CSF3, MPO
8butyrate459.4GATA1, MPO, MYB
9gm-csf45 2910.4CSF3, CSF2RA
10aclarubicin459.3MYB, GATA1, CSF3
11methimazole45 2 1111.2CSF3, MPO
12methylcellulose459.2CSF3, MYB
13mitoxantrone45 50 1111.1MPO, CSF3
14cytarabine45 50 1111.1CSF3, GATA1, MPO
15imatinib45 50 1111.0ETV6, MYB, CSF3
1612-o-tetradecanoylphorbol 13-acetate459.0IL3RA, IL18R1, MYB, GATA1
17clozapine45 29 50 1112.0IL18R1, MPO, CSF3
18doxorubicin45 50 1111.0MYB, GATA1, CSF3
19zinc45 249.9IL3RA, IL18R1, MYB, GATA1
20n-formylmethionyl-leucylphenylalanine458.8MPO, CSF3
21cyclosporin a45 29 6010.8IL18R1, MYB, CSF3
22dmso458.8CSF3, GATA1, MPO, MYB
23serine458.6CSF2RA, GATA1, MPO, MYB, IL18R1
24gp 130458.5CSF2RA, CSF3, IL18R1, IL3RA
25prednisolone45 29 1110.5IL18R1, ETV6, MPO, CSF3
26thymidine45 249.5IL3RA, IL18R1, MYB, CSF3
27vegf457.8CSF3, GATA1, MPO, MYB, ETV6, IL18R1
28retinoic acid45 248.8CSF3, GATA1, MPO, MYB, ETV6, IL18R1
29tyrosine457.6CSF2RA, CSF3, MYB, ETV6, IL18R1, IL3RA

GO Terms for genes affiliated with Acute Basophilic Leukemia

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Sources:
16Gene Ontology
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Molecular functions related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.2MYB, MPO, GATA1

Products for genes affiliated with Acute Basophilic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Basophilic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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