Acute Basophilic Leukemia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Acute Basophilic Leukemia

Sources:
⁶⁴Wikipedia, ³²MalaCards
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Wikipedia:⁶⁴ Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards based summary: Acute Basophilic Leukemia is related to hodgkin's lymphoma and leukemia. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and IL-3 Signaling Pathway. The drug thioguanine and the compounds nitroblue tetrazolium and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Acute Basophilic Leukemia

Sources:
⁴⁸Orphanet, ⁶¹UMLS, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet
See all sources

Acute Basophilic Leukemia, Aliases & Descriptions:

Name: Acute Basophilic Leukemia ⁴⁸ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases

ICD10: ²⁷

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Other leukaemias of specified cell type

Other specified leukaemias

Orphanet: ⁴⁸

Rare haematological diseases

Rare tumors

External Ids:

MESH via Orphanet³⁵ D015471

ICD10 via Orphanet²⁷ C94.7

UMLS via Orphanet⁶² C0023437

Related Diseases for Acute Basophilic Leukemia

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)

id	Related Disease	Score	Top Affiliating Genes
1	hodgkin's lymphoma	30.3	IL3RA, IL18R1, CSF3
2	leukemia	29.7	MPO, MYB, ETV6, IL3RA, IL18R1, CSF2RA
3	myelodysplastic syndromes	29.7	GATA1, CSF3, ETV6, MPO
4	langerhans-cell histiocytosis	10.2
5	mast-cell leukemia	10.2
6	gastric ulcer	10.2
7	histiocytosis	10.2
8	acute myelomonocytic leukemia	10.2	MPO, ETV6
9	monocytic leukemia	10.2	GATA1
10	peritonitis	10.2	IL18R1, MPO
11	leukemia, acute lymphoblastic 3	10.1	MPO, ETV6
12	leukopenia	10.1	CSF3, MPO
13	eosinophilia	10.0	MPO, ETV6, IL3RA
14	allergic rhinitis	10.0	IL18R1, MPO
15	acute promyelocytic leukemia	10.0	MPO, CSF3
16	megakaryocytic leukemia	10.0	GATA1, MPO
17	neutropenia	10.0	MPO, CSF3
18	septic shock	10.0	CSF3, IL18R1
19	leukemoid reaction	10.0	GATA1, CSF3
20	hematologic cancer	10.0	ETV6, IL3RA, CSF3
21	aplastic anemia	9.9	GATA1, CSF3
22	pdgfrb-associated chronic eosinophilic leukemia	9.9	MPO, ETV6, CSF3
23	sepsis	9.9	MPO, IL18R1, CSF3
24	chronic lymphocytic leukemia	9.9	CSF2RA, IL18R1, IL3RA, MYB
25	non-hodgkin lymphoma	9.9	CSF3, ETV6, MYB
26	wilms tumor	9.8	GATA1, IL18R1, MYB
27	lung cancer	9.8	CSF3, IL18R1, MYB
28	thrombocytopenia	9.8	MYB, CSF3, GATA1
29	deficiency anemia	9.7	MYB, CSF3, GATA1
30	rheumatoid arthritis	9.7	MPO, MYB, IL18R1
31	burkitt's lymphoma	9.7	MYB, ETV6, IL3RA, CSF3
32	breast cancer	9.5	MYB, ETV6, IL3RA, IL18R1, CSF3
33	precursor t-cell acute lymphoblastic leukemia	9.4	GATA1, IL18R1, ETV6, MYB, MPO
34	bone marrow cancer	9.4	MPO, ETV6, IL18R1, CSF3, GATA1
35	chronic myeloid leukemia	9.2	MPO, MYB, ETV6, CSF2RA, CSF3, GATA1
36	acute leukemia	9.0	GATA1, MPO, MYB, ETV6, IL3RA, IL18R1
37	acute lymphoblastic leukemia	9.0	MPO, MYB, ETV6, IL3RA, IL18R1, CSF3
38	myeloid leukemia	9.0	MPO, MYB, ETV6, IL3RA, IL18R1, CSF3

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:

Symptoms for Acute Basophilic Leukemia

Drugs & Therapeutics for Acute Basophilic Leukemia

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

thioguanine

Genetic Tests for Acute Basophilic Leukemia

Anatomical Context for Acute Basophilic Leukemia

Sources:
³²MalaCards
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MalaCards organs/tissues related to Acute Basophilic Leukemia:

³²

Myeloid, Bone marrow, Bone, Liver, Testes

Animal Models for Acute Basophilic Leukemia or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	8.4	GATA1, CSF3, ETV6, MYB
2	hematopoietic system phenotype	MP:0005397	7.3	GATA1, CSF3, IL18R1, ETV6, MYB, MPO
3	immune system phenotype	MP:0005387	7.1	MPO, MYB, ETV6, IL18R1, CSF3, GATA1

Publications for Acute Basophilic Leukemia

Sources:
⁵¹PubMed
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Articles related to Acute Basophilic Leukemia:

(show all 27)

id	Title	Authors	Year
1	Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. (25364419)	Luo X.H.... Tang X.Q.	2014
2	Acute basophilic leukemia. (24949509)	Eveillard M.... Desjonqueres A.	2014
3	Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)	Zhao Y.H.... Zhou J.	2013
4	A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)	Jeong T.D.... Lee J.H.	2013
5	Acute basophilic leukemia in an infant with proptosis. (21393925)	Ghosh I.... Gupta R.	2011
6	Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)	Kritharis A.... Allen S.L.	2011
7	Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)	Quelen C.... Brousset P.	2011
8	Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)	Rojas-Atencio A.... Solis E.	2011
9	A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)	Pidala J.... Cualing H.D.	2008
10	Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)	Shin S.Y.... Jo D.Y.	2007
11	Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)	Moser A.M.... Kapelushnik J.	2006
12	Acute basophilic leukemia with t(8;21). (15160925)	Seth T.... Kochupillai V.	2004
13	Acute basophilic leukemia: case report. (15164378)	Gupta R.... Anand M.	2004
14	Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)	Yokohama A.... Nojima Y.	2002
15	Acute basophilic leukemia. (11722593)	Giagounidis A.A.... Aul C.	2001
16	Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)	Scolyer R.A.... Webb M.	2000
17	Diagnosis of acute basophilic leukemia. (10037024)	Duchayne E.... Dastugue N.	1999
18	Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)	Bernini J.C.... Sandler E.S.	1995
19	An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)	Shekhter-Levin S.... Gollin S.M.	1995
20	Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)	Travis L.B.... Li C.Y.	1993
21	Acute basophilic leukemia. (1489389)	Schumacher H.R.... Skelly M.E.	1992
22	Acute basophilic leukemia. A case report. (1718580)	Kuo C.Y.... Chen W.J.	1991
23	Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)	Peterson L.C.... Brunning R.D.	1991
24	Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)	Dick F.R.	1991
25	Acute basophilic leukemia. (6731465)	Shah I.... Koppitch F.	1984
26	Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)	Liso V.... Specchia G.	1978
27	Follow-up of sixty two cases of acute basophilic leukemia. (667277)	Quattrin N.	1978

Genes related to Acute Basophilic Leukemia

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁴⁸Orphanet
See all sources

Genes related to Acute Basophilic Leukemia:

- Elite gene

id	Symbol	Description	Score	Implication
1	GATA1	GATA binding protein 1 (globin transcription factor 1)	20.00	Gene fusion ⁴⁸
2	MYB	v-myb avian myeloblastosis viral oncogene homolog	17.50	Gene fusion ⁴⁸
3	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	16.25	GeneCards inferred via : Publications (show sections)
4	IL18R1	interleukin 18 receptor 1	13.75	GeneCards inferred via : Publications (show sections)
5	MPO	myeloperoxidase	11.25	GeneCards inferred via : Publications (show sections)
6	IL3RA	interleukin 3 receptor, alpha (low affinity)	8.75	GeneCards inferred via : Publications (show sections)
7	ETV6	ets variant 6	6.25	GeneCards inferred via : Publications (show sections)
8	CSF3	colony stimulating factor 3 (granulocyte)	3.75	GeneCards inferred via : Publications (show sections)

Products for genes related to Acute Basophilic Leukemia disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	8	-	8	8
2	Novus Biologicals	8	8	8	-

Variations for Acute Basophilic Leukemia

Expression for genes affiliated with Acute Basophilic Leukemia

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ⁵Cell Signaling Technology, ³⁰KEGG, ⁵²QIAGEN
See all sources

Pathways related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Notch-mediated HES/HEY network³⁷	9.8	GATA1, MYB
2	IL-3 Signaling Pathway³⁷	9.5	GATA1, IL3RA
3	Signaling by Interleukins⁵⁴ Show member pathways Interleukin-3, 5 and GM-CSF signaling⁵⁴ Interleukin-1 processing⁵⁴ Regulation of signaling by CBL⁵⁴ Interleukin-6 signaling⁵⁴ Interleukin-2 signaling⁵⁴ Interleukin-7 signaling⁵⁴ Interleukin receptor SHC signaling⁵⁴	9.4	CSF2RA, IL3RA
4	C-MYB transcription factor network³⁷	9.2	GATA1, MYB, MPO
5	Lymphocyte Signaling⁵	9.2	MPO, MYB, GATA1
6	PI3K-Akt signaling pathway³⁰	9.0	MYB, IL3RA, CSF3
7	Hematopoietic cell lineage³⁰	8.9	CSF3, CSF2RA, IL3RA
8	Jak-STAT signaling pathway³⁰ Show member pathways Type III interferon signaling³⁷	8.9	IL3RA, CSF2RA, CSF3
9	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.5	CSF3, CSF2RA, IL18R1, IL3RA
10	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	8.5	IL3RA, IL18R1, CSF2RA, CSF3
11	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.5	IL3RA, IL18R1, CSF2RA, CSF3
12	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.5	IL3RA, IL18R1, CSF2RA, CSF3

Compounds for genes affiliated with Acute Basophilic Leukemia

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ¹²DrugBank, ³BitterDB, ²⁵HMDB, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	nitroblue tetrazolium⁴⁴	9.9	MYB, CSF3
2	vesnarinone⁴⁴	9.9	CSF3, IL18R1
3	methylcellulose⁴⁴	9.9	CSF3, MYB
4	gm-csf⁴⁴ ²⁹	10.9	CSF3, CSF2RA
5	filgrastim⁴⁴ ¹²	10.9	IL18R1, CSF3
6	alpha-naphthyl butyrate⁴⁴	9.8	CSF3, MPO
7	propylthiouracil⁴⁴ ³ ¹²	11.8	CSF3, MPO
8	4-hydroxynonenal⁴⁴ ²⁵	10.8	MYB, MPO
9	methimazole⁴⁴ ³ ¹²	11.8	CSF3, MPO
10	mitoxantrone⁴⁴ ⁵⁰ ¹²	11.7	CSF3, MPO
11	n-formylmethionyl-leucylphenylalanine⁴⁴	9.7	MPO, CSF3
12	aclarubicin⁴⁴	9.7	MYB, CSF3, GATA1
13	daunorubicin⁴⁴ ⁵⁰ ¹²	11.7	MPO, CSF3
14	hydroxyurea⁴⁴ ⁵⁰ ¹²	11.6	GATA1, CSF3
15	chloramphenicol⁴⁴ ³ ⁵⁰ ¹²	12.6	GATA1, MYB, MPO
16	butyrate⁴⁴	9.6	GATA1, MYB, MPO
17	polyethylene glycol⁴⁴	9.6	IL18R1, MPO
18	doxorubicin⁴⁴ ⁵⁰ ¹²	11.6	MYB, CSF3, GATA1
19	carboplatin⁴⁴ ⁵⁰ ¹²	11.5	MPO, CSF3
20	leucine⁴⁴	9.5	GATA1, IL18R1, MYB
21	iron⁴⁴ ²⁵	10.5	GATA1, MYB, MPO
22	cytarabine⁴⁴ ⁵⁰ ¹²	11.5	MPO, CSF3, GATA1
23	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	13.4	MYB, IL18R1, GATA1
24	cycloheximide⁴⁴	9.4	GATA1, CSF3, MYB
25	cyclosporin a⁴⁴ ²⁹ ⁶⁰	11.4	MYB, IL18R1, CSF3
26	clozapine⁴⁴ ²⁹ ⁵⁰ ¹²	12.4	MPO, IL18R1, CSF3
27	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	12.2	CSF3, IL18R1, MPO
28	steroid⁴⁴	9.2	MYB, IL18R1, GATA1
29	imatinib⁴⁴ ⁵⁰ ¹²	11.1	CSF3, ETV6, MYB
30	dmso⁴⁴	9.1	MPO, MYB, CSF3, GATA1
31	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	12.1	CSF3, IL18R1, MYB
32	12-o-tetradecanoylphorbol 13-acetate⁴⁴	9.1	GATA1, IL18R1, IL3RA, MYB
33	zinc⁴⁴ ²⁵	10.0	GATA1, IL18R1, IL3RA, MYB
34	oligonucleotide⁴⁴	9.0	GATA1, IL18R1, MYB
35	thymidine⁴⁴ ²⁵	9.9	CSF3, IL18R1, IL3RA, MYB
36	gp 130⁴⁴	8.9	CSF3, CSF2RA, IL18R1, IL3RA
37	serine⁴⁴	8.7	MPO, MYB, IL18R1, CSF2RA, GATA1
38	prednisolone⁴⁴ ²⁹ ¹²	10.6	CSF3, IL18R1, ETV6, MPO
39	vegf⁴⁴	7.9	GATA1, CSF3, IL18R1, ETV6, MYB, MPO
40	retinoic acid⁴⁴ ²⁵	8.9	MPO, MYB, ETV6, IL18R1, CSF3, GATA1
41	tyrosine⁴⁴	7.7	MYB, ETV6, IL3RA, IL18R1, CSF2RA, CSF3