MCID: ACT177
MIFTS: 33

Acute Basophilic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Acute Basophilic Leukemia

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Sources:
48Orphanet, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Acute Basophilic Leukemia:

Name: Acute Basophilic Leukemia 48 61


Classifications:



External Ids:

Orphanet48 86849
MESH via Orphanet34 D015471
ICD10 via Orphanet26 C94.7
UMLS via Orphanet62 C0023437

Summaries for Acute Basophilic Leukemia

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Wikipedia:64 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards based summary: Acute Basophilic Leukemia is related to leukemia and myelodysplastic syndrome. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and IL-3 Signaling Pathway. The drug thioguanine and the compounds nitroblue tetrazolium and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are integument and hematopoietic system.

Related Diseases for Acute Basophilic Leukemia

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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia29.7IL18R1, MPO, MYB, ETV6, IL3RA, GATA1
2myelodysplastic syndrome29.7MPO, ETV6, CSF3, GATA1
3langerhans-cell histiocytosis10.2
4mast-cell leukemia10.2
5gastric ulcer10.2
6histiocytosis10.2
7acute myelomonocytic leukemia10.2ETV6, MPO
8monocytic leukemia10.1GATA1
9peritonitis10.1MPO, IL18R1
10precursor b-cell acute lymphoblastic leukemia10.1ETV6, MPO
11granulocytopenia10.1MPO, CSF3
12leukopenia10.1CSF3, MPO
13allergic rhinitis10.0IL18R1, MPO
14eosinophilia10.0IL3RA, ETV6, MPO
15megakaryocytic leukemia10.0MPO, GATA1
16leukemia, acute promyelocytic10.0CSF3, MPO
17hodgkin lymphoma10.0IL3RA, IL18R1, CSF3
18neutropenia10.0CSF3, MPO
19leukemoid reaction10.0CSF3, GATA1
20hematologic cancer10.0ETV6, IL3RA, CSF3
21chronic myelomonocytic leukemia9.9ETV6, MPO, CSF3
22aplastic anemia9.9CSF3, GATA1
23chronic lymphocytic leukemia9.9IL18R1, IL3RA, MYB, CSF2RA
24wilms tumor9.8IL18R1, MYB, GATA1
25lymphoma, non-hodgkin9.8CSF3, MYB, ETV6
26lung cancer9.8CSF3, MYB, IL18R1
27thrombocytopenia9.8GATA1, CSF3, MYB
28rheumatoid arthritis9.7MPO, MYB, IL18R1
29deficiency anemia9.7MYB, GATA1, CSF3
30burkitt lymphoma9.7ETV6, MYB, CSF3, IL3RA
31breast cancer9.5MYB, CSF3, IL18R1, IL3RA, ETV6
32precursor t-cell acute lymphoblastic leukemia9.4ETV6, GATA1, MPO, MYB, IL18R1
33bone marrow cancer9.4ETV6, MPO, CSF3, GATA1, IL18R1
34leukemia, chronic myeloid9.2ETV6, CSF2RA, CSF3, GATA1, MYB, MPO
35acute leukemia9.0CSF3, IL18R1, IL3RA, ETV6, MYB, GATA1
36leukemia, acute lymphoblastic9.0MPO, ETV6, MYB, GATA1, CSF3, IL18R1
37myeloid leukemia9.0MYB, GATA1, CSF3, IL18R1, IL3RA, ETV6

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Symptoms for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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MalaCards organs/tissues related to Acute Basophilic Leukemia:

31
Myeloid, Bone marrow, Bone, Liver, Testes

Animal Models for Acute Basophilic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4GATA1, CSF3, ETV6, MYB
2MP:00053977.3GATA1, CSF3, IL18R1, ETV6, MYB, MPO
3MP:00053877.1MPO, MYB, ETV6, IL18R1, CSF3, GATA1

Publications for Acute Basophilic Leukemia

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Articles related to Acute Basophilic Leukemia:

(show all 27)
idTitleAuthorsYear
1
Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. (25364419)
2014
2
Acute basophilic leukemia. (24949509)
2014
3
Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)
2013
4
A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)
2013
5
Acute basophilic leukemia in an infant with proptosis. (21393925)
2011
6
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)
2011
7
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)
2011
8
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)
2011
9
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
2008
10
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)
2007
11
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)
2006
12
Acute basophilic leukemia with t(8;21). (15160925)
2004
13
Acute basophilic leukemia: case report. (15164378)
2004
14
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)
2002
15
Acute basophilic leukemia. (11722593)
2001
16
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)
2000
17
Diagnosis of acute basophilic leukemia. (10037024)
1999
18
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)
1995
19
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)
1995
20
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)
1993
21
Acute basophilic leukemia. (1489389)
1992
22
Acute basophilic leukemia. A case report. (1718580)
1991
23
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)
1991
24
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)
1991
25
Acute basophilic leukemia. (6731465)
1984
26
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
27
Follow-up of sixty two cases of acute basophilic leukemia. (667277)
1978

Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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Pathways related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GATA1, MYB
29.5GATA1, IL3RA
3
Show member pathways
9.4CSF2RA, IL3RA
49.2GATA1, MYB, MPO
59.2MPO, MYB, GATA1
69.0MYB, IL3RA, CSF3
78.9CSF3, CSF2RA, IL3RA
8
Show member pathways
Type III interferon signaling36
8.9IL3RA, CSF2RA, CSF3
9
Show member pathways
8.5CSF3, CSF2RA, IL18R1, IL3RA
10
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
11
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
12
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3

Compounds for genes affiliated with Acute Basophilic Leukemia

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Compounds related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1nitroblue tetrazolium449.9CSF3, MYB
2vesnarinone449.9CSF3, IL18R1
3methylcellulose449.9CSF3, MYB
4gm-csf44 2810.9CSF3, CSF2RA
5filgrastim44 1110.9CSF3, IL18R1
6alpha-naphthyl butyrate449.8MPO, CSF3
7propylthiouracil44 1 1111.8MPO, CSF3
84-hydroxynonenal44 2410.8MYB, MPO
9methimazole44 1 1111.8MPO, CSF3
10mitoxantrone44 50 1111.7CSF3, MPO
11n-formylmethionyl-leucylphenylalanine449.7CSF3, MPO
12aclarubicin449.7MYB, CSF3, GATA1
13daunorubicin44 50 1111.7CSF3, MPO
14hydroxyurea44 50 1111.6CSF3, GATA1
15chloramphenicol44 1 50 1112.6GATA1, MYB, MPO
16carboplatin44 50 1111.6MPO, CSF3
17butyrate449.6MPO, MYB, GATA1
18polyethylene glycol449.6IL18R1, MPO
19doxorubicin44 50 1111.6GATA1, MYB, CSF3
20leucine449.5GATA1, IL18R1, MYB
21iron44 2410.5MPO, GATA1, MYB
22cytarabine44 50 1111.5MPO, CSF3, GATA1
23cycloheximide449.4MYB, GATA1, CSF3
24cyclosporin a44 28 6011.4MYB, IL18R1, CSF3
25progesterone44 28 60 24 1113.4MYB, GATA1, IL18R1
26clozapine44 28 50 1112.4MPO, IL18R1, CSF3
27cisplatin44 50 60 1112.2MPO, CSF3, IL18R1
28steroid449.2MYB, GATA1, IL18R1
29imatinib44 50 1111.1MYB, ETV6, CSF3
30dmso449.1MYB, CSF3, GATA1, MPO
31dexamethasone44 50 28 1112.1IL18R1, CSF3, MYB
3212-o-tetradecanoylphorbol 13-acetate449.1MYB, IL18R1, IL3RA, GATA1
33zinc44 2410.0IL3RA, IL18R1, GATA1, MYB
34oligonucleotide449.0MYB, IL18R1, GATA1
35thymidine44 249.9MYB, IL18R1, CSF3, IL3RA
36gp 130448.9IL3RA, IL18R1, CSF2RA, CSF3
37serine448.7MPO, MYB, IL18R1, CSF2RA, GATA1
38prednisolone44 28 1110.6CSF3, MPO, ETV6, IL18R1
39vegf447.9GATA1, CSF3, IL18R1, ETV6, MYB, MPO
40retinoic acid44 248.9MPO, MYB, ETV6, CSF3, GATA1, IL18R1
41tyrosine447.7ETV6, IL3RA, MYB, CSF2RA, IL18R1, CSF3

GO Terms for genes affiliated with Acute Basophilic Leukemia

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Biological processes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6GATA1, CSF3

Sources for Acute Basophilic Leukemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet