MCID: ACT177
MIFTS: 33

Acute Basophilic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases categories

Summaries for Acute Basophilic Leukemia

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Wikipedia:63 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards based summary: Acute Basophilic Leukemia is related to leukemia and myelodysplastic syndrome. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and IL-3 Signaling Pathway. The drug thioguanine and the compounds nitroblue tetrazolium and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Acute Basophilic Leukemia

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Sources:
47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Acute Basophilic Leukemia, Aliases & Descriptions:

Name: Acute Basophilic Leukemia 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Orphanet47 86849
MESH via Orphanet34 D015471
ICD10 via Orphanet26 C94.7
UMLS via Orphanet61 C0023437

Related Diseases for Acute Basophilic Leukemia

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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia29.7IL18R1, MPO, MYB, ETV6, IL3RA, GATA1
2myelodysplastic syndrome29.7MPO, ETV6, CSF3, GATA1
3langerhans-cell histiocytosis10.2
4mast-cell leukemia10.2
5gastric ulcer10.2
6histiocytosis10.2
7acute myelomonocytic leukemia10.2ETV6, MPO
8monocytic leukemia10.1GATA1
9peritonitis10.1MPO, IL18R1
10precursor b-cell acute lymphoblastic leukemia10.1ETV6, MPO
11granulocytopenia10.1MPO, CSF3
12leukopenia10.1CSF3, MPO
13allergic rhinitis10.0IL18R1, MPO
14eosinophilia10.0IL3RA, ETV6, MPO
15megakaryocytic leukemia10.0MPO, GATA1
16leukemia, acute promyelocytic10.0CSF3, MPO
17hodgkin lymphoma10.0IL3RA, IL18R1, CSF3
18neutropenia10.0CSF3, MPO
19leukemoid reaction10.0CSF3, GATA1
20hematologic cancer10.0ETV6, IL3RA, CSF3
21chronic myelomonocytic leukemia9.9ETV6, MPO, CSF3
22aplastic anemia9.9CSF3, GATA1
23chronic lymphocytic leukemia9.9IL18R1, IL3RA, MYB, CSF2RA
24wilms tumor9.8IL18R1, MYB, GATA1
25lymphoma, non-hodgkin9.8CSF3, MYB, ETV6
26lung cancer9.8CSF3, MYB, IL18R1
27thrombocytopenia9.8GATA1, CSF3, MYB
28rheumatoid arthritis9.7MPO, MYB, IL18R1
29deficiency anemia9.7MYB, GATA1, CSF3
30burkitt lymphoma9.7ETV6, MYB, CSF3, IL3RA
31breast cancer9.5MYB, CSF3, IL18R1, IL3RA, ETV6
32precursor t-cell acute lymphoblastic leukemia9.4ETV6, GATA1, MPO, MYB, IL18R1
33bone marrow cancer9.4ETV6, MPO, CSF3, GATA1, IL18R1
34leukemia, chronic myeloid9.2ETV6, CSF2RA, CSF3, GATA1, MYB, MPO
35acute leukemia9.0CSF3, IL18R1, IL3RA, ETV6, MYB, GATA1
36leukemia, acute lymphoblastic9.0MPO, ETV6, MYB, GATA1, CSF3, IL18R1
37myeloid leukemia9.0MYB, GATA1, CSF3, IL18R1, IL3RA, ETV6

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Symptoms for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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MalaCards organs/tissues related to Acute Basophilic Leukemia:

31
Myeloid, Bone marrow, Bone, Liver, Testes

Animal Models for Acute Basophilic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4GATA1, CSF3, ETV6, MYB
2MP:00053977.3GATA1, CSF3, IL18R1, ETV6, MYB, MPO
3MP:00053877.1MPO, MYB, ETV6, IL18R1, CSF3, GATA1

Publications for Acute Basophilic Leukemia

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Articles related to Acute Basophilic Leukemia:

(show all 27)
idTitleAuthorsYear
1
Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. (25364419)
2014
2
Acute basophilic leukemia. (24949509)
2014
3
Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)
2013
4
A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)
2013
5
Acute basophilic leukemia in an infant with proptosis. (21393925)
2011
6
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)
2011
7
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)
2011
8
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)
2011
9
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
2008
10
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)
2007
11
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)
2006
12
Acute basophilic leukemia with t(8;21). (15160925)
2004
13
Acute basophilic leukemia: case report. (15164378)
2004
14
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)
2002
15
Acute basophilic leukemia. (11722593)
2001
16
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)
2000
17
Diagnosis of acute basophilic leukemia. (10037024)
1999
18
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)
1995
19
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)
1995
20
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)
1993
21
Acute basophilic leukemia. (1489389)
1992
22
Acute basophilic leukemia. A case report. (1718580)
1991
23
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)
1991
24
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)
1991
25
Acute basophilic leukemia. (6731465)
1984
26
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
27
Follow-up of sixty two cases of acute basophilic leukemia. (667277)
1978

Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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Pathways related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GATA1, MYB
29.5GATA1, IL3RA
3
Show member pathways
9.4CSF2RA, IL3RA
49.2GATA1, MYB, MPO
59.2MPO, MYB, GATA1
69.0MYB, IL3RA, CSF3
78.9CSF3, CSF2RA, IL3RA
8
Show member pathways
Type III interferon signaling36
8.9IL3RA, CSF2RA, CSF3
9
Show member pathways
8.5CSF3, CSF2RA, IL18R1, IL3RA
10
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
11
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
12
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3

Compounds for genes affiliated with Acute Basophilic Leukemia

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Compounds related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1nitroblue tetrazolium439.9MYB, CSF3
2vesnarinone439.9CSF3, IL18R1
3methylcellulose439.9CSF3, MYB
4gm-csf43 2810.9CSF3, CSF2RA
5filgrastim43 1210.9IL18R1, CSF3
6alpha-naphthyl butyrate439.8CSF3, MPO
7propylthiouracil43 2 1211.8CSF3, MPO
84-hydroxynonenal43 2410.8MYB, MPO
9methimazole43 2 1211.8CSF3, MPO
10mitoxantrone43 49 1211.7CSF3, MPO
11n-formylmethionyl-leucylphenylalanine439.7MPO, CSF3
12aclarubicin439.7MYB, CSF3, GATA1
13daunorubicin43 49 1211.7MPO, CSF3
14hydroxyurea43 49 1211.6GATA1, CSF3
15chloramphenicol43 2 49 1212.6GATA1, MYB, MPO
16butyrate439.6GATA1, MYB, MPO
17polyethylene glycol439.6IL18R1, MPO
18doxorubicin43 49 1211.6MYB, CSF3, GATA1
19carboplatin43 49 1211.5MPO, CSF3
20leucine439.5GATA1, IL18R1, MYB
21iron43 2410.5GATA1, MYB, MPO
22cytarabine43 49 1211.5MPO, CSF3, GATA1
23progesterone43 28 59 24 1213.4MYB, IL18R1, GATA1
24cycloheximide439.4GATA1, CSF3, MYB
25cyclosporin a43 28 5911.4MYB, IL18R1, CSF3
26clozapine43 28 49 1212.4MPO, IL18R1, CSF3
27cisplatin43 49 59 1212.2CSF3, IL18R1, MPO
28steroid439.2MYB, IL18R1, GATA1
29imatinib43 49 1211.1CSF3, ETV6, MYB
30dmso439.1MPO, MYB, CSF3, GATA1
31dexamethasone43 49 28 1212.1CSF3, IL18R1, MYB
3212-o-tetradecanoylphorbol 13-acetate439.1GATA1, IL18R1, IL3RA, MYB
33zinc43 2410.0GATA1, IL18R1, IL3RA, MYB
34oligonucleotide439.0GATA1, IL18R1, MYB
35thymidine43 249.9CSF3, IL18R1, IL3RA, MYB
36gp 130438.9CSF3, CSF2RA, IL18R1, IL3RA
37serine438.7MPO, MYB, IL18R1, CSF2RA, GATA1
38prednisolone43 28 1210.6CSF3, IL18R1, ETV6, MPO
39vegf437.9GATA1, CSF3, IL18R1, ETV6, MYB, MPO
40retinoic acid43 248.9MPO, MYB, ETV6, IL18R1, CSF3, GATA1
41tyrosine437.7MYB, ETV6, IL3RA, IL18R1, CSF2RA, CSF3

GO Terms for genes affiliated with Acute Basophilic Leukemia

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Biological processes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6GATA1, CSF3

Products for genes affiliated with Acute Basophilic Leukemia

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Sources for Acute Basophilic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet