MCID: ACT177
MIFTS: 38

Acute Basophilic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases categories
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Summaries for Acute Basophilic Leukemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards: Acute Basophilic Leukemia is related to leukemia and hodgkin's lymphoma. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and IL-3 Signaling Pathway. The drug thioguanine and the compounds nitroblue tetrazolium and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Acute Basophilic Leukemia

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49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

acute basophilic leukemia 49 62


External Ids:

MESH via Orphanet36 D015471
ICD10 via Orphanet26 C94.7
SNOMED-CT via Orphanet59 69077002
UMLS via Orphanet63 C0023437

Related Diseases for Acute Basophilic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.9MPO, MYB, ETV6, IL3RA, IL18R1, CSF2RA
2hodgkin's lymphoma30.3IL3RA, IL18R1, CSF3
3myelodysplastic syndromes30.1GATA1, CSF3, ETV6, MPO
4langerhans-cell histiocytosis10.2
5mast-cell leukemia10.2
6histiocytosis10.2
7acute myelomonocytic leukemia10.0MPO, ETV6
8monocytic leukemia10.0GATA1
9peritonitis10.0IL18R1, MPO
10leukemia, acute lymphoblastic 310.0MPO, ETV6
11leukopenia10.0CSF3, MPO
12eosinophilia10.0MPO, ETV6, IL3RA
13allergic rhinitis10.0IL18R1, MPO
14acute promyelocytic leukemia10.0MPO, CSF3
15megakaryocytic leukemia10.0GATA1, MPO
16neutropenia10.0MPO, CSF3
17septic shock10.0CSF3, IL18R1
18leukemoid reaction10.0GATA1, CSF3
19hematologic cancer10.0ETV6, IL3RA, CSF3
20aplastic anemia10.0GATA1, CSF3
21chronic myelomonocytic leukemia10.0MPO, ETV6, CSF3
22sepsis10.0MPO, IL18R1, CSF3
23chronic lymphocytic leukemia10.0CSF2RA, IL18R1, IL3RA, MYB
24non-hodgkin lymphoma10.0CSF3, ETV6, MYB
25wilms tumor10.0GATA1, IL18R1, MYB
26lung cancer9.9CSF3, IL18R1, MYB
27thrombocytopenia9.9MYB, CSF3, GATA1
28deficiency anemia9.9MYB, CSF3, GATA1
29rheumatoid arthritis9.9MPO, MYB, IL18R1
30burkitt's lymphoma9.9MYB, ETV6, IL3RA, CSF3
31breast cancer9.9MYB, ETV6, IL3RA, IL18R1, CSF3
32precursor t-cell acute lymphoblastic leukemia9.9GATA1, IL18R1, ETV6, MYB, MPO
33myeloproliferative disorder9.9MPO, ETV6, IL18R1, CSF3, GATA1
34chronic myeloid leukemia9.8MPO, MYB, ETV6, CSF2RA, CSF3, GATA1
35acute leukemia9.8GATA1, MPO, MYB, ETV6, IL3RA, IL18R1
36acute lymphocytic leukemia9.8MPO, MYB, ETV6, IL3RA, IL18R1, CSF3
37myeloid leukemia9.8MPO, MYB, ETV6, IL3RA, IL18R1, CSF3

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Symptoms for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Acute Basophilic Leukemia:

33
Myeloid, Bone marrow, Bone, Liver, Testes

Animal Models for Acute Basophilic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4MYB, ETV6, CSF3, GATA1
2MP:00053977.3MPO, MYB, ETV6, IL18R1, CSF3, GATA1
3MP:00053877.1MPO, MYB, ETV6, IL18R1, CSF3, GATA1

Publications for Acute Basophilic Leukemia

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52PubMed
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Articles related to Acute Basophilic Leukemia:

(show all 25)
idTitleAuthorsYear
1
Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)
2013
2
A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)
2013
3
Acute basophilic leukemia in an infant with proptosis. (21393925)
2011
4
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)
2011
5
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)
2011
6
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)
2011
7
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
2008
8
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)
2007
9
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)
2006
10
Acute basophilic leukemia with t(8;21). (15160925)
2004
11
Acute basophilic leukemia: case report. (15164378)
2004
12
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)
2002
13
Acute basophilic leukemia. (11722593)
2001
14
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)
2000
15
Diagnosis of acute basophilic leukemia. (10037024)
1999
16
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)
1995
17
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)
1995
18
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)
1993
19
Acute basophilic leukemia. (1489389)
1992
20
Acute basophilic leukemia. A case report. (1718580)
1991
21
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)
1991
22
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)
1991
23
Acute basophilic leukemia. (6731465)
1984
24
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
25
Follow-up of sixty two cases of acute basophilic leukemia. (667277)
1978

Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 30KEGG, 53QIAGEN
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Pathways related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GATA1, MYB
29.5GATA1, IL3RA
3
Show member pathways
9.4CSF2RA, IL3RA
49.2GATA1, MYB, MPO
59.2MPO, MYB, GATA1
69.0MYB, IL3RA, CSF3
78.9CSF3, CSF2RA, IL3RA
8
Show member pathways
Type III interferon signaling38
8.9IL3RA, CSF2RA, CSF3
9
Show member pathways
8.5CSF3, CSF2RA, IL18R1, IL3RA
10
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
11
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
12
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3

Compounds for genes affiliated with Acute Basophilic Leukemia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 3BitterDB, 24HMDB, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1nitroblue tetrazolium459.9CSF3, MYB
2vesnarinone459.9CSF3, IL18R1
3methylcellulose459.9CSF3, MYB
4gm-csf45 2910.9CSF3, CSF2RA
5filgrastim45 1110.9CSF3, IL18R1
6alpha-naphthyl butyrate459.8MPO, CSF3
7propylthiouracil45 3 1111.8MPO, CSF3
84-hydroxynonenal45 2410.8MYB, MPO
9methimazole45 3 1111.8MPO, CSF3
10mitoxantrone45 51 1111.7CSF3, MPO
11n-formylmethionyl-leucylphenylalanine459.7CSF3, MPO
12aclarubicin459.7MYB, CSF3, GATA1
13daunorubicin45 51 1111.7CSF3, MPO
14hydroxyurea45 51 1111.6CSF3, GATA1
15chloramphenicol45 3 51 1112.6GATA1, MYB, MPO
16carboplatin45 51 1111.6MPO, CSF3
17butyrate459.6MPO, MYB, GATA1
18polyethylene glycol459.6IL18R1, MPO
19doxorubicin45 51 1111.6GATA1, MYB, CSF3
20leucine459.5GATA1, IL18R1, MYB
21iron45 2410.5MPO, GATA1, MYB
22cytarabine45 51 1111.5MPO, CSF3, GATA1
23cycloheximide459.4MYB, GATA1, CSF3
24cyclosporin a45 29 6111.4MYB, IL18R1, CSF3
25progesterone45 29 61 24 1113.4MYB, GATA1, IL18R1
26clozapine45 29 51 1112.4MPO, IL18R1, CSF3
27cisplatin45 51 61 1112.2MPO, CSF3, IL18R1
28steroid459.2MYB, GATA1, IL18R1
29imatinib45 51 1111.1MYB, ETV6, CSF3
30dmso459.1MYB, CSF3, GATA1, MPO
31dexamethasone45 51 29 1112.1IL18R1, CSF3, MYB
3212-o-tetradecanoylphorbol 13-acetate459.1MYB, IL18R1, IL3RA, GATA1
33zinc45 2410.0IL3RA, IL18R1, GATA1, MYB
34oligonucleotide459.0MYB, IL18R1, GATA1
35thymidine45 249.9MYB, IL18R1, CSF3, IL3RA
36gp 130458.9IL3RA, IL18R1, CSF2RA, CSF3
37serine458.7MPO, MYB, IL18R1, CSF2RA, GATA1
38prednisolone45 29 1110.6CSF3, MPO, ETV6, IL18R1
39vegf457.9GATA1, CSF3, IL18R1, ETV6, MYB, MPO
40retinoic acid45 248.9MPO, MYB, ETV6, CSF3, GATA1, IL18R1
41tyrosine457.7ETV6, IL3RA, MYB, CSF2RA, IL18R1, CSF3

GO Terms for genes affiliated with Acute Basophilic Leukemia

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16Gene Ontology
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Biological processes related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6GATA1, CSF3

Products for genes affiliated with Acute Basophilic Leukemia

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Sources for Acute Basophilic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet