MCID: ACT177
MIFTS: 38

Acute Basophilic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases categories
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Summaries for Acute Basophilic Leukemia

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Wikipedia:65 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards based summary: Acute Basophilic Leukemia is related to hodgkin's lymphoma and leukemia. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and IL-3 Signaling Pathway. The drug thioguanine and the compounds nitroblue tetrazolium and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Acute Basophilic Leukemia

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Sources:
48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Acute Basophilic Leukemia, Aliases & Descriptions:

Name: Acute Basophilic Leukemia 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

MESH via Orphanet35 D015471
ICD10 via Orphanet26 C94.7
UMLS via Orphanet63 C0023437

Related Diseases for Acute Basophilic Leukemia

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Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma30.3IL3RA, IL18R1, CSF3
2leukemia29.7IL18R1, MPO, MYB, ETV6, IL3RA, GATA1
3myelodysplastic syndromes29.7MPO, ETV6, CSF3, GATA1
4langerhans-cell histiocytosis10.2
5mast-cell leukemia10.2
6gastric ulcer10.2
7histiocytosis10.2
8acute myelomonocytic leukemia10.2ETV6, MPO
9monocytic leukemia10.2GATA1
10peritonitis10.2MPO, IL18R1
11leukemia, acute lymphoblastic 310.1ETV6, MPO
12leukopenia10.1CSF3, MPO
13eosinophilia10.0IL3RA, ETV6, MPO
14allergic rhinitis10.0IL18R1, MPO
15acute promyelocytic leukemia10.0CSF3, MPO
16megakaryocytic leukemia10.0MPO, GATA1
17neutropenia10.0CSF3, MPO
18septic shock10.0IL18R1, CSF3
19leukemoid reaction10.0CSF3, GATA1
20hematologic cancer10.0ETV6, IL3RA, CSF3
21aplastic anemia9.9CSF3, GATA1
22pdgfrb-associated chronic eosinophilic leukemia9.9ETV6, MPO, CSF3
23sepsis9.9IL18R1, CSF3, MPO
24chronic lymphocytic leukemia9.9IL18R1, IL3RA, MYB, CSF2RA
25non-hodgkin lymphoma9.9CSF3, MYB, ETV6
26wilms tumor9.8IL18R1, MYB, GATA1
27lung cancer9.8CSF3, MYB, IL18R1
28thrombocytopenia9.8GATA1, CSF3, MYB
29deficiency anemia9.7MYB, GATA1, CSF3
30rheumatoid arthritis9.7MPO, MYB, IL18R1
31burkitt's lymphoma9.7ETV6, MYB, CSF3, IL3RA
32breast cancer9.5MYB, CSF3, IL18R1, IL3RA, ETV6
33precursor t-cell acute lymphoblastic leukemia9.4ETV6, GATA1, MPO, MYB, IL18R1
34bone marrow cancer9.4ETV6, MPO, CSF3, GATA1, IL18R1
35chronic myeloid leukemia9.2ETV6, CSF2RA, CSF3, GATA1, MYB, MPO
36acute leukemia9.0CSF3, IL18R1, IL3RA, ETV6, MYB, GATA1
37acute lymphoblastic leukemia9.0MPO, ETV6, MYB, GATA1, CSF3, IL18R1
38myeloid leukemia9.0MYB, GATA1, CSF3, IL18R1, IL3RA, ETV6

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to acute basophilic leukemia

Symptoms for Acute Basophilic Leukemia

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Drugs & Therapeutics for Acute Basophilic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Acute Basophilic Leukemia

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Anatomical Context for Acute Basophilic Leukemia

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MalaCards organs/tissues related to Acute Basophilic Leukemia:

32
Myeloid, Bone marrow, Bone, Liver, Testes

Animal Models for Acute Basophilic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4GATA1, CSF3, ETV6, MYB
2MP:00053977.3GATA1, CSF3, IL18R1, ETV6, MYB, MPO
3MP:00053877.1MPO, MYB, ETV6, IL18R1, CSF3, GATA1

Publications for Acute Basophilic Leukemia

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Articles related to Acute Basophilic Leukemia:

(show all 27)
idTitleAuthorsYear
1
Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. (25364419)
2014
2
Acute basophilic leukemia. (24949509)
2014
3
Arsenic trioxide in treatment of de novo acute basophilic leukemia. (23422134)
2013
4
A case of Langerhans cell histiocytosis following acute basophilic leukemia. (22895553)
2013
5
Acute basophilic leukemia in an infant with proptosis. (21393925)
2011
6
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. (21576634)
2011
7
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (21474671)
2011
8
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. (22937382)
2011
9
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
2008
10
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. (17213028)
2007
11
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. (16965955)
2006
12
Acute basophilic leukemia with t(8;21). (15160925)
2004
13
Acute basophilic leukemia: case report. (15164378)
2004
14
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. (11999362)
2002
15
Acute basophilic leukemia. (11722593)
2001
16
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. (10740808)
2000
17
Diagnosis of acute basophilic leukemia. (10037024)
1999
18
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. (7804964)
1995
19
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. (8536230)
1995
20
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. (8257517)
1993
21
Acute basophilic leukemia. (1489389)
1992
22
Acute basophilic leukemia. A case report. (1718580)
1991
23
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. (1862771)
1991
24
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? (1862770)
1991
25
Acute basophilic leukemia. (6731465)
1984
26
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
27
Follow-up of sixty two cases of acute basophilic leukemia. (667277)
1978

Variations for Acute Basophilic Leukemia

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Expression for genes affiliated with Acute Basophilic Leukemia

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Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

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Pathways related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GATA1, MYB
29.5GATA1, IL3RA
3
Show member pathways
9.4CSF2RA, IL3RA
49.2GATA1, MYB, MPO
59.2MPO, MYB, GATA1
69.0MYB, IL3RA, CSF3
78.9CSF3, CSF2RA, IL3RA
8
Show member pathways
Type III interferon signaling37
8.9IL3RA, CSF2RA, CSF3
9
Show member pathways
8.5CSF3, CSF2RA, IL18R1, IL3RA
10
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
11
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3
12
Show member pathways
8.5IL3RA, IL18R1, CSF2RA, CSF3

Compounds for genes affiliated with Acute Basophilic Leukemia

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Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1nitroblue tetrazolium449.9MYB, CSF3
2vesnarinone449.9CSF3, IL18R1
3methylcellulose449.9CSF3, MYB
4gm-csf44 2810.9CSF3, CSF2RA
5filgrastim44 1110.9IL18R1, CSF3
6alpha-naphthyl butyrate449.8CSF3, MPO
7propylthiouracil44 2 1111.8CSF3, MPO
84-hydroxynonenal44 2410.8MYB, MPO
9methimazole44 2 1111.8CSF3, MPO
10mitoxantrone44 50 1111.7CSF3, MPO
11n-formylmethionyl-leucylphenylalanine449.7MPO, CSF3
12aclarubicin449.7MYB, CSF3, GATA1
13daunorubicin44 50 1111.7MPO, CSF3
14hydroxyurea44 50 1111.6GATA1, CSF3
15chloramphenicol44 2 50 1112.6GATA1, MYB, MPO
16butyrate449.6GATA1, MYB, MPO
17polyethylene glycol449.6IL18R1, MPO
18doxorubicin44 50 1111.6MYB, CSF3, GATA1
19carboplatin44 50 1111.5MPO, CSF3
20leucine449.5GATA1, IL18R1, MYB
21iron44 2410.5GATA1, MYB, MPO
22cytarabine44 50 1111.5MPO, CSF3, GATA1
23progesterone44 28 61 24 1113.4MYB, IL18R1, GATA1
24cycloheximide449.4GATA1, CSF3, MYB
25cyclosporin a44 28 6111.4MYB, IL18R1, CSF3
26clozapine44 28 50 1112.4MPO, IL18R1, CSF3
27cisplatin44 50 61 1112.2CSF3, IL18R1, MPO
28steroid449.2MYB, IL18R1, GATA1
29imatinib44 50 1111.1CSF3, ETV6, MYB
30dmso449.1MPO, MYB, CSF3, GATA1
31dexamethasone44 50 28 1112.1CSF3, IL18R1, MYB
3212-o-tetradecanoylphorbol 13-acetate449.1GATA1, IL18R1, IL3RA, MYB
33zinc44 2410.0GATA1, IL18R1, IL3RA, MYB
34oligonucleotide449.0GATA1, IL18R1, MYB
35thymidine44 249.9CSF3, IL18R1, IL3RA, MYB
36gp 130448.9CSF3, CSF2RA, IL18R1, IL3RA
37serine448.7MPO, MYB, IL18R1, CSF2RA, GATA1
38prednisolone44 28 1110.6CSF3, IL18R1, ETV6, MPO
39vegf447.9GATA1, CSF3, IL18R1, ETV6, MYB, MPO
40retinoic acid44 248.9MPO, MYB, ETV6, IL18R1, CSF3, GATA1
41tyrosine447.7MYB, ETV6, IL3RA, IL18R1, CSF2RA, CSF3

GO Terms for genes affiliated with Acute Basophilic Leukemia

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Biological processes related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6GATA1, CSF3

Products for genes affiliated with Acute Basophilic Leukemia

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  • Antibodies
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Sources for Acute Basophilic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet