Acute Basophilic Leukemia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Acute Basophilic Leukemia

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

MalaCards: Acute Basophilic Leukemia is related to acute leukemia and leukemia. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA binding protein 1 (globin transcription factor 1)), and among its related pathways are Notch-mediated HES/HEY network and C-MYB transcription factor network. The drug thioguanine and the compounds Sargramostim and nitroblue tetrazolium have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Acute Basophilic Leukemia

Sources:
⁴⁸Orphanet, ⁶⁰UMLS, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases

ICD10: ²⁶

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Other leukaemias of specified cell type

Other specified leukaemias

Aliases & Descriptions:

acute basophilic leukemia ⁴⁸ ⁶⁰

External Ids:

MESH via Orphanet³⁵ D015471

ICD10 via Orphanet²⁶ C94.7

SNOMED-CT via Orphanet⁵⁷ 69077002

UMLS via Orphanet⁶¹ C0023437

Related Diseases for Acute Basophilic Leukemia

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)

id	Related Disease	Score	Top Affiliating Genes
1	acute leukemia	31.2	IL3RA, MPO, IL18R1, ETV6, GATA1, CSF3
2	leukemia	31.2	MYB, CSF2RA, IL3RA, GATA1, ETV6, MPO
3	hodgkin's lymphoma	30.2	IL18R1, IL3RA, CSF3
4	mast-cell leukemia	10.2
5	histiocytosis	10.2
6	langerhans-cell histiocytosis	10.2
7	myelofibrosis	10.0	GATA1
8	monocytic leukemia	10.0	GATA1
9	alpha thalassemia	10.0	GATA1
10	pulmonary alveolar proteinosis	10.0	CSF2RA
11	viral hepatitis	10.0	MYB
12	vasculitis	10.0	MPO
13	prostate cancer	10.0	IL18R1, CSF2RA
14	multiple sclerosis	10.0	IL18R1
15	splenomegaly	10.0	CSF3
16	asthma	10.0	MPO, IL18R1
17	megakaryocytic leukemia	10.0	GATA1, MPO
18	leukemoid reaction	10.0	CSF3, GATA1
19	hepatitis c	10.0	MYB
20	neutropenia	10.0	CSF3, MPO
21	aplastic anemia	10.0	CSF3, GATA1
22	sarcoma	10.0	ETV6, IL18R1
23	glioblastoma multiforme	10.0	MYB, IL18R1
24	acute myelomonocytic leukemia	10.0	MPO, ETV6
25	wilms tumor	10.0	GATA1, IL18R1, MYB
26	deficiency anemia	10.0	CSF3, MYB, GATA1
27	precursor b-cell acute lymphoblastic leukemia	10.0	MPO, ETV6
28	thrombocytopenia	10.0	CSF3, GATA1, MYB
29	fibrosarcoma	10.0	ETV6, MYB
30	chronic lymphocytic leukemia	10.0	CSF2RA, MYB, IL18R1, IL3RA
31	eosinophilia	10.0	MPO, ETV6, IL3RA
32	sepsis	10.0	MPO, IL18R1, CSF3
33	hematologic cancer	10.0	CSF3, IL3RA, ETV6
34	chronic myelomonocytic leukemia	10.0	ETV6, MPO, CSF3
35	non-hodgkin lymphoma	10.0	ETV6, MYB, CSF3
36	myelodysplastic syndromes	10.0	MPO, GATA1, CSF3, ETV6
37	burkitt's lymphoma	10.0	IL3RA, CSF3, MYB, ETV6
38	precursor t-cell acute lymphoblastic leukemia	10.0	GATA1, IL18R1, MPO, ETV6, MYB
39	myeloproliferative disorder	10.0	CSF3, GATA1, IL18R1, MPO, ETV6
40	breast cancer	10.0	IL18R1, MYB, CSF3, IL3RA, ETV6
41	chronic myeloid leukemia	9.9	MYB, CSF2RA, MPO, GATA1, CSF3, ETV6
42	acute lymphocytic leukemia	9.9	GATA1, MYB, CSF3, MPO, ETV6, IL18R1
43	myeloid leukemia	9.9	MPO, ETV6, IL3RA, IL18R1, MYB, GATA1

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:

Clinical Features for Acute Basophilic Leukemia

Drugs & Therapeutics for Acute Basophilic Leukemia

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Basophilic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Basophilic Leukemia

Search NIH Clinical Center for Acute Basophilic Leukemia

Search CenterWatch for Acute Basophilic Leukemia

Inferred drug relations via UMLS⁶⁰/NDF-RT⁴⁰:

thioguanine

Genetic Tests for Acute Basophilic Leukemia

Anatomical Context for Acute Basophilic Leukemia

Sources:
³²MalaCards
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MalaCards organs/tissues related to Acute Basophilic Leukemia:

³²

Myeloid

Animal Models for Acute Basophilic Leukemia or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	7.9	ETV6, MYB, MPO, GATA1, CSF3
2	immune system phenotype	MP:0005387	7.1	IL18R1, CSF3, GATA1, MPO, MYB, ETV6

Publications for Acute Basophilic Leukemia

Genes related to Acute Basophilic Leukemia

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁸Orphanet
See all sources

Genes related to Acute Basophilic Leukemia:

id	Symbol	Description	Score	Implication
1	GATA1	GATA binding protein 1 (globin transcription factor 1)	21.24	Gene fusion ⁴⁸ GeneCards inferred : Disorders (show sections)
2	MYB	v-myb avian myeloblastosis viral oncogene homolog	17.50	Gene fusion ⁴⁸
3	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	16.24	GeneCards inferred : Publications, Disorders (show sections)
4	IL18R1	interleukin 18 receptor 1	13.74	GeneCards inferred : Publications, Disorders (show sections)
5	MPO	myeloperoxidase	11.24	GeneCards inferred : Publications, Disorders (show sections)
6	IL3RA	interleukin 3 receptor, alpha (low affinity)	8.74	GeneCards inferred : Publications, Disorders (show sections)
7	CSF3	colony stimulating factor 3 (granulocyte)	6.24	GeneCards inferred : Publications, Disorders (show sections)
8	ETV6	ets variant 6	3.74	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Acute Basophilic Leukemia disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	8	8	8
2	LSBio	-	-	8

Genetic Variations for Acute Basophilic Leukemia

Expression for genes affiliated with Acute Basophilic Leukemia

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for genes affiliated with Acute Basophilic Leukemia

Sources:
³⁷NCBI BioSystems Database, ⁴Cell Signaling Technology, ²⁹KEGG, ⁵¹QIAGEN
See all sources

Pathways related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Notch-mediated HES/HEY network³⁷	9.8	GATA1, MYB
2	C-MYB transcription factor network³⁷	9.2	MYB, MPO, GATA1
3	Lymphocyte Signaling⁴	9.2	MYB, MPO, GATA1
4	PI3K-Akt signaling pathway²⁹	8.7	IL3RA, MYB, CSF3
5	Jak-STAT signaling pathway²⁹	8.6	CSF2RA, CSF3, IL3RA
6	Hematopoietic cell lineage²⁹	8.6	IL3RA, CSF3, CSF2RA
7	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	8.2	CSF2RA, CSF3, IL18R1, IL3RA
8	PAK Pathway⁵¹ Hide members Antioxidant Action of Vitamin-C⁵¹	8.2	CSF2RA, CSF3, IL18R1, IL3RA
9	Rho Family GTPases⁵¹ Hide members Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹	8.2	IL3RA, IL18R1, CSF3, CSF2RA
10	PEDF Induced Signaling⁵¹ Hide members Cytokine-cytokine receptor interaction²⁹ STAT3 Pathway⁵¹ PGC1Alpha Pathway⁵¹ Glucocorticoid Receptor Signaling⁵¹ all-trans-Retinoic Acid Signaling in Brain⁵¹ RAR-Gamma-RXR-Alpha Degradation⁵¹ IL-6 Pathway⁵¹ Endothelin-1 Signaling Pathway⁵¹ MIF Regulation of Innate Immune Cells⁵¹ MIF Mediated Glucocorticoid Regulation⁵¹	8.2	IL3RA, IL18R1, CSF3, CSF2RA

Compounds for genes affiliated with Acute Basophilic Leukemia

Sources:
¹¹DrugBank, ⁴⁴Novoseek, ²BitterDB, ²⁸IUPHAR, ⁴⁹PharmGKB, ²⁴HMDB, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

(show all 29)

id	Compound	Score	Top Affiliating Genes
1	Sargramostim¹¹	9.8	CSF2RA, IL3RA
2	nitroblue tetrazolium⁴⁴	9.5	CSF3, MYB
3	vesnarinone⁴⁴	9.5	IL18R1, CSF3
4	alpha-naphthyl butyrate⁴⁴	9.5	MPO, CSF3
5	chloramphenicol⁴⁴ ² ¹¹	11.5	GATA1, MPO, MYB
6	filgrastim⁴⁴ ¹¹	10.5	IL18R1, CSF3
7	propylthiouracil⁴⁴ ² ¹¹	11.4	CSF3, MPO
8	butyrate⁴⁴	9.4	MPO, MYB, GATA1
9	gm-csf⁴⁴ ²⁸	10.4	CSF2RA, CSF3
10	aclarubicin⁴⁴	9.3	MYB, GATA1, CSF3
11	methimazole⁴⁴ ² ¹¹	11.2	MPO, CSF3
12	methylcellulose⁴⁴	9.2	MYB, CSF3
13	mitoxantrone⁴⁴ ⁴⁹ ¹¹	11.1	CSF3, MPO
14	cytarabine⁴⁴ ⁴⁹ ¹¹	11.1	GATA1, MPO, CSF3
15	imatinib⁴⁴ ⁴⁹ ¹¹	11.0	CSF3, MYB, ETV6
16	12-o-tetradecanoylphorbol 13-acetate⁴⁴	9.0	IL3RA, IL18R1, MYB, GATA1
17	clozapine⁴⁴ ²⁸ ⁴⁹ ¹¹	12.0	IL18R1, MPO, CSF3
18	doxorubicin⁴⁴ ⁴⁹ ¹¹	11.0	GATA1, CSF3, MYB
19	zinc⁴⁴ ²⁴	9.9	IL18R1, IL3RA, MYB, GATA1
20	n-formylmethionyl-leucylphenylalanine⁴⁴	8.8	CSF3, MPO
21	cyclosporin a⁴⁴ ²⁸ ⁵⁹	10.8	CSF3, IL18R1, MYB
22	dmso⁴⁴	8.8	MYB, MPO, GATA1, CSF3
23	serine⁴⁴	8.6	MPO, CSF2RA, IL18R1, MYB, GATA1
24	gp 130⁴⁴	8.5	IL3RA, IL18R1, CSF3, CSF2RA
25	prednisolone⁴⁴ ²⁸ ¹¹	10.5	ETV6, IL18R1, MPO, CSF3
26	thymidine⁴⁴ ²⁴	9.5	IL3RA, CSF3, MYB, IL18R1
27	vegf⁴⁴	7.8	CSF3, GATA1, MPO, MYB, ETV6, IL18R1
28	retinoic acid⁴⁴ ²⁴	8.8	ETV6, IL18R1, GATA1, CSF3, MYB, MPO
29	tyrosine⁴⁴	7.6	IL3RA, IL18R1, ETV6, MYB, CSF3, CSF2RA

GO Terms for genes affiliated with Acute Basophilic Leukemia

Sources:
¹⁶Gene Ontology
See all sources

Molecular functions related to Acute Basophilic Leukemia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:003682	9.2	MYB, MPO, GATA1

Products for genes affiliated with Acute Basophilic Leukemia

Antibodies
Proteins
Lysates

Antibodies

Sources for Acute Basophilic Leukemia

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

MCID: ACT177 MIFTS: 29	Acute Basophilic Leukemia malady Blood diseases, Cancer diseases categories
1 drug, 8 genes, 1 tissue, 43 related diseases, clinical trials.

Acute Basophilic Leukemia malady