BAL
MCID: ACT095
MIFTS: 47

Acute Biphenotypic Leukemia (BAL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Acute Biphenotypic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards: Acute Biphenotypic Leukemia, also known as acute leukemia of ambiguous lineage, is related to acute leukemia and leukemia. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds nabumetone and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include myeloid and bone, and related mouse phenotypes are embryogenesis and cardiovascular system.

Aliases & Classifications for Acute Biphenotypic Leukemia

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42NIH Rare Diseases, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute leukemia of ambiguous lineage:
Age of onset: Variable


Aliases & Descriptions:

acute biphenotypic leukemia 42 48 30 60
acute leukemia of ambiguous lineage 42 48
acute leukemia of indeterminate lineage 48
acute leukemia of undetermined lineage 42
mixed phenotype acute leukemia 48
mixed lineage acute leukemia 48
aml with lymphoid markers 42
all with myeloid markers 42
hybrid acute leukemia 48
bal 42


External Ids:

MESH via Orphanet35 D015456
ICD10 via Orphanet26 C95.0
SNOMED-CT via Orphanet57 128818009, 278453007, 397345009
UMLS via Orphanet61 C0023464, C1301357

Related Diseases for Acute Biphenotypic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.3NOTCH1, KMT2A, ABL1, DNTT, MPO, MLLT10
2leukemia31.3TLX1, FLT3, MLLT10, MPO, DNTT, ABL1
3acute myeloid leukemia30.6FLT3, MLLT10
4myeloid leukemia30.6FLT3, MLLT10, MPO, DNTT, ABL1, KMT2A
5lymphoblastic leukemia30.5TLX1
6myeloid sarcoma30.3MPO
7myeloma30.3NOTCH1, DNTT
8monocytic leukemia30.3KMT2A, F3
9acute monocytic leukemia30.3KMT2A, MPO, MLLT10
10chronic myeloid leukemia30.2FLT3, MPO, DNTT, ABL1, KMT2A
11peritonitis30.0MPO, F2
12adenocarcinoma29.8NOTCH1, KMT2A
13sarcoidosis10.5
14pneumonia10.5
15pulmonary sarcoidosis10.4
16lymphoid leukemia10.3
17asthma10.3
18pulmonary fibrosis10.3
19bronchiolitis obliterans10.2
20bronchiolitis10.2
21eosinophilic pneumonia10.2
22acute t cell leukemia10.2
23pharyngitis10.2
24invasive aspergillosis10.2
25arthritis10.2
26aspergillosis10.2
27multiple myeloma10.2
28sarcoma10.2
29t-cell leukemia10.2
30bronchiolitis obliterans organizing pneumonia10.2
31asbestosis10.1
32extrinsic allergic alveolitis10.1
33interstitial lung disease10.1
34tuberculosis10.1
35nonspecific interstitial pneumonia10.0
36pulmonary tuberculosis10.0
37cystic fibrosis10.0
38idiopathic pulmonary fibrosis10.0
39pulmonary edema10.0
40hemosiderosis10.0
41bronchiectasis10.0
42neuronitis10.0
43bronchitis10.0
44lung cancer10.0
45porphyria10.0
46respiratory failure10.0
47peripheral vascular disease10.0MPO
48wegener's granulomatosis10.0MPO
49hemarthrosis10.0F3
50factor xii deficiency10.0F3

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Clinical Features for Acute Biphenotypic Leukemia

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Drugs & Therapeutics for Acute Biphenotypic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Acute Biphenotypic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Search CenterWatch for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

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Anatomical Context for Acute Biphenotypic Leukemia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

32
Myeloid, Bone

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F2, KMT2A, F3, TLX1
2MP:00053858.0F2, NOTCH1, F3, ABL1, KMT2A, MPO
3MP:00107687.7NOTCH1, FLT3, MPO, F3, ABL1, F2
4MP:00053767.4KMT2A, ABL1, FLT3, F2, F3, MPO
5MP:00053847.0ABL1, FLT3, TLX1, DNTT, F3, F2
6MP:00053976.8TLX1, KMT2A, NOTCH1, MPO, F2, ABL1
7MP:00053876.7NOTCH1, KMT2A, DNTT, F2, ABL1, MPO

Publications for Acute Biphenotypic Leukemia

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Genetic Variations for Acute Biphenotypic Leukemia

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Expression for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Biphenotypic Leukemia

Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1nabumetone44 1111.1MPO, F2
2aprosulate4410.1F3, F2
3napsagatran4410.0F3, F2
4brodifacoum4410.0F3, F2
5hemochron4410.0F3, F2
6certoparin4410.0F3, F2
7appt4410.0F3, F2
8heparin sodium4410.0F3, F2
9inogatran4410.0F3, F2
10ecarin4410.0F3, F2
11dextran 704410.0F3, F2
12polybrene4410.0F3, F2
13spectrozyme4410.0F3, F2
14s-warfarin4410.0F3, F2
15danaparoid4410.0F3, F2
16hepaplastin4410.0F3, F2
17kaolin4410.0F3, F2
18organon4410.0F3, F2
19rivaroxaban44 1110.9F3, F2
20ximelagatran44 1110.9F3, F2
21vitamin k144 2410.9F3, F2
22heparinoids449.9F3, F2
23aminopyrine449.9MPO, F2
24fondaparinux449.9F2, F3
25acenocoumarol44 49 1111.9F2, F3
26naphthol as-d chloroacetate449.9MPO, DNTT
27coumarins449.9F3, F2
28phenprocoumon44 49 1111.8F3, F2
29argatroban44 1110.8F3, F2
30hydroxyethyl starch449.8F3, F2
31ppack449.7F2, F3
32bivalirudin44 1110.7MPO, F3, F2
33tranexamic acid44 1110.7F3, F2
34kininogen449.7F2, F3, MPO
35protamine sulfate449.6F3, F2
36epsilon aminocaproic acid449.6F2, F3
37cytarabine44 49 1111.6FLT3, MPO, ABL1
38tirofiban44 1110.5F2, F3
39Ponatinib 119.3ABL1, FLT3
40nucleoside449.3ABL1, DNTT, FLT3
41af 10449.3TLX1, MLLT10, KMT2A
42lactate449.0FLT3, MPO, DNTT, F2
43dmso448.9MPO, DNTT, F3, ABL1
44vegf448.8FLT3, MPO, F3, ABL1, NOTCH1
45threonine448.8TLX1, FLT3, ABL1, KMT2A, NOTCH1
46oligonucleotide448.6TLX1, FLT3, DNTT, ABL1, KMT2A
47zinc44 249.1TLX1, MLLT10, DNTT, ABL1, KMT2A
48retinoic acid44 249.0NOTCH1, KMT2A, ABL1, F3, DNTT, MPO
49aspartate447.9NOTCH1, KMT2A, F2, ABL1, F3, DNTT
50serine447.9MPO, DNTT, F3, ABL1, F2, KMT2A

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

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16Gene Ontology
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Biological processes related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:0082848.6NOTCH1, F2, FLT3, TLX1
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.5NOTCH1, KMT2A, MLLT10, TLX1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.8NOTCH1, KMT2A, F2, ABL1, F3, MLLT10

Products for genes affiliated with Acute Biphenotypic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Biphenotypic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet