MCID: ACT095
MIFTS: 57

Acute Biphenotypic Leukemia malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Acute Biphenotypic Leukemia

About this section


Wikipedia:65 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards based summary: Acute Biphenotypic Leukemia, also known as acute undifferentiated leukemia, is related to leukemia and acute leukemia. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds aprosulate and napsagatran have been mentioned in the context of this disorder. Affiliated tissues include b cells, myeloid and bone, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Acute Biphenotypic Leukemia

About this section
Sources:
32LifeMap Discovery®, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Acute Biphenotypic Leukemia, Aliases & Descriptions:

Name: Acute Biphenotypic Leukemia 32 43 49 62
Acute Undifferentiated Leukemia 45 49 62
Acute Leukemia of Ambiguous Lineage 43 62
Undifferentiated Acute Leukemia 43 62
B-Cell Prolymphocytic Leukemia 43 49
Biphenotypic Acute Leukemia 43 62
Hybrid Acute Leukemia 43 62
B-Pll 43 49
Acute Leukemia of Undetermined Lineage 43
 
Mixed Phenotype Acute Leukaemia 62
Leukemia, B Cell Prolymphocytic 43
Mixed Phenotype Acute Leukemia 43
B Cell Prolymphocytic Leukemia 43
Mixed Lineage Acute Leukemia 43
Mixed-Lineage Acute Leukemia 62
Aml with Lymphoid Markers 43
All with Myeloid Markers 43
Bal 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
b-cell prolymphocytic leukemia:
Age of onset: Adult


External Ids:

Orphanet49 86852, 98837, 98835
MESH via Orphanet36 D054403, D015456
ICD10 via Orphanet28 C91.3, C95.0
UMLS via Orphanet63 C0475801, C0023464, C0856823
ICD1027 C91.3

Related Diseases for Acute Biphenotypic Leukemia

About this section

Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2MLLT10, ABL1, NOTCH1, DNTT, FLT3, MPO
2acute leukemia30.9FLT3, DNTT, NOTCH1, ABL1, MLLT10, KMT2A
3chronic lymphocytic leukemia30.6FLT3, KMT2A, ABL1, DNTT
4lymphoblastic lymphoma30.6KMT2A, DNTT, MPO, NOTCH1
5myeloid leukemia30.5FLT3, DNTT, KMT2A, MPO, MLLT10, ABL1
6lymphoblastic leukemia30.5TLX1
7myeloid sarcoma30.5MPO
8precursor t-cell acute lymphoblastic leukemia30.2TLX1, NOTCH1, DNTT, KMT2A, MPO, MLLT10
9peritonitis30.1F2, MPO
10prolymphocytic leukemia11.1
11mercury poisoning10.6
12pneumonia10.5
13essential thrombocythemia10.5
14meningitis10.5
15pulmonary sarcoidosis10.4
16lymphoid leukemia10.4
17tetraploidy10.4
18pulmonary fibrosis10.3
19hematopoietic stem cell transplantation10.3
20hemolytic anemia10.3
21mantle cell lymphoma10.3
22pure red-cell aplasia10.3
23autoimmune hemolytic anemia10.3
24hypercalcemia10.3
25polyradiculoneuropathy10.3
26asthma10.3
27bronchiolitis obliterans10.3
28bronchiolitis10.3
29breast cancer10.3
30aspergillosis10.3
31multiple myeloma10.3
32arthritis10.3
33sinusitis10.3
34pharyngitis10.3
35myeloma10.3
36sarcoma10.3
37eosinophilic pneumonia10.2
38polycythemia vera10.2
39glucocorticoid resistance10.2
40polycythemia10.2
41thymoma10.2
42acute erythroblastic leukemia10.2
43bronchiolitis obliterans organizing pneumonia10.2
44asbestosis10.2
45extrinsic allergic alveolitis10.2
46interstitial lung disease10.2
47tuberculosis10.2
48heavy metal poisoning10.2
49gingivitis10.2
50cystic fibrosis10.1

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Symptoms for Acute Biphenotypic Leukemia

About this section

Drugs & Therapeutics for Acute Biphenotypic Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

About this section

Anatomical Context for Acute Biphenotypic Leukemia

About this section

MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

33
B cells, Myeloid, Bone, Monocytes, T cells

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1NOTCH1, F3, FLT3, KMT2A
2MP:00053698.6ABL1, KMT2A, MPO, F3, NOTCH1
3MP:00053858.2ABL1, F3, KMT2A, MPO, F2, NOTCH1
4MP:00053808.1NOTCH1, KMT2A, TLX1, ABL1, F2, F3
5MP:00028738.0F2, ABL1, NOTCH1, F3, DNTT
6MP:00036317.9KMT2A, NOTCH1, TLX1, ABL1, F2, F3
7MP:00053767.9F2, MPO, F3, NOTCH1, ABL1, KMT2A
8MP:00053787.8ABL1, F3, F2, NOTCH1, KMT2A, FLT3
9MP:00107687.8MPO, ABL1, KMT2A, FLT3, F2, NOTCH1
10MP:00053847.8FLT3, F2, ABL1, TLX1, KMT2A, F3
11MP:00053976.9MPO, ABL1, TLX1, KMT2A, F2, FLT3
12MP:00053876.8TLX1, F2, MPO, FLT3, F3, ABL1

Publications for Acute Biphenotypic Leukemia

About this section

Articles related to Acute Biphenotypic Leukemia:

(show all 25)
idTitleAuthorsYear
1
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
2
Lateral pharyngeal wall myeloid sarcoma as a relapse of acute biphenotypic leukemia: a case report and review of the literature. (24377982)
2013
3
Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. (21151021)
2011
4
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
5
Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy. (19752004)
2009
6
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. (19380030)
2009
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Nelarabine activity in acute biphenotypic leukemia. (17512588)
2007
9
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia. (16823822)
2006
10
Arthritis preceding acute biphenotypic leukemia. (16220224)
2006
11
Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (17207092)
2006
12
Acute biphenotypic leukemia and an acquired X chromosome. (15676158)
2005
13
Successful treatment of massive gastrointestinal hemorrhage in acute biphenotypic leukemia with recombinant factor VIIa (NovoSeven). (15060424)
2004
14
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
15
Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. (12953816)
2003
16
Acute biphenotypic leukemia in the adults. (12408768)
2002
17
Establishment of a cell line with variant BCR/ABL breakpoint expressing P180BCR/ABL from late-appearing Philadelphia-positive acute biphenotypic leukemia. (9790503)
1998
18
Definition of acute biphenotypic leukemia. (9107085)
1997
19
Trisomy 4 as the sole karyotypic anomaly in acute biphenotypic leukemia with B lineage markers and in acute minimally differentiated myeloid leukemia (M0). (7697636)
1995
20
An adult case of acute biphenotypic leukemia with characteristic mixed morphology. (8232165)
1993
21
Chromosome 21 rearrangement in acute biphenotypic leukemia. (1360869)
1992
22
Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. (1913454)
1991
23
Trisomy 4 in a case of acute biphenotypic leukemia. (2357699)
1990
24
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (2838522)
1988
25
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987

Variations for Acute Biphenotypic Leukemia

About this section

Expression for genes affiliated with Acute Biphenotypic Leukemia

About this section

Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

About this section

Pathways related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.7F3, F2
2
Show member pathways
9.7F3, F2
39.0FLT3, KMT2A, MPO, TLX1

Compounds for genes affiliated with Acute Biphenotypic Leukemia

About this section
Sources:
45Novoseek, 13DrugBank, 26HMDB, 51PharmGKB, 30IUPHAR
See all sources

Compounds related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1aprosulate4510.2F2, F3
2napsagatran4510.2F2, F3
3brodifacoum4510.2F2, F3
4mnpt4510.2F2, F3
5certoparin4510.1F2, F3
6appt4510.1F2, F3
7hemochron4510.1F2, F3
8inogatran4510.1F3, F2
9heparin sodium4510.1F3, F2
10dextran 704510.1F2, F3
11ecarin4510.1F2, F3
12polybrene4510.1F2, F3
13spectrozyme4510.1F2, F3
14s-warfarin4510.1F2, F3
15danaparoid4510.1F2, F3
16hepaplastin4510.1F2, F3
17nabumetone45 1311.1F2, MPO
18rivaroxaban45 1311.1F2, F3
19kaolin4510.1F2, F3
20ximelagatran45 1311.1F2, F3
21organon4510.0F2, F3
22vitamin k145 2611.0F2, F3
23heparinoids4510.0F2, F3
24fondaparinux4510.0F3, F2
25acenocoumarol45 51 1312.0F3, F2
26phenprocoumon45 51 1311.9F2, F3
27coumarins459.9F2, F3
28hydroxyethyl starch459.9F2, F3
29naphthol as-d chloroacetate459.8MPO, DNTT
30aminopyrine459.8F2, MPO
31argatroban45 1310.8F2, F3
32bivalirudin45 1310.8F2, MPO, F3
33ppack459.8F3, F2
34kininogen459.7F3, MPO, F2
35tranexamic acid45 1310.7F2, F3
36protamine sulfate459.6F2, F3
37cytarabine45 51 1311.5ABL1, MPO, FLT3
38tirofiban45 1310.4F3, F2
39nucleoside459.3DNTT, FLT3, ABL1
40af 10459.3KMT2A, TLX1, MLLT10
41phosphatidylserine45 30 1311.2F3, ABL1, F2
42dmso459.1ABL1, MPO, F3, DNTT
43lactate459.0F2, MPO, FLT3, DNTT
44vegf458.9ABL1, MPO, FLT3, F3, NOTCH1
45threonine458.7ABL1, TLX1, KMT2A, FLT3, NOTCH1
46oligonucleotide458.6ABL1, TLX1, KMT2A, FLT3, DNTT
47zinc45 269.1ABL1, MLLT10, TLX1, KMT2A, DNTT
48retinoic acid45 269.0ABL1, MPO, KMT2A, FLT3, F3, DNTT
49aspartate457.9NOTCH1, F2, ABL1, KMT2A, FLT3, F3
50serine457.9F2, ABL1, MPO, KMT2A, F3, DNTT

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

About this section

Cellular components related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.4NOTCH1, F3, FLT3
2nucleusGO:00056346.6NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A

Biological processes related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.4FLT3, F2
2negative regulation of cell proliferationGO:00082859.4NOTCH1, FLT3, KMT2A
3positive regulation of cell proliferationGO:00082848.8NOTCH1, FLT3, TLX1, F2
4positive regulation of transcription from RNA polymerase II promoterGO:00459448.3MLLT10, TLX1, KMT2A, NOTCH1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00037008.4NOTCH1, KMT2A, TLX1, MLLT10
2protein bindingGO:00055156.5NOTCH1, F2, ABL1, MLLT10, TLX1, KMT2A

Products for genes affiliated with Acute Biphenotypic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acute Biphenotypic Leukemia

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet