BAL
MCID: ACT095
MIFTS: 49

Acute Biphenotypic Leukemia (BAL) malady

Blood, Cancer, Immune categories

Summaries for Acute Biphenotypic Leukemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards: Acute Biphenotypic Leukemia, also known as acute leukemia of ambiguous lineage, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds nabumetone and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, breast and myeloid, and related mouse phenotypes are embryogenesis and cardiovascular system.

Aliases & Classifications for Acute Biphenotypic Leukemia

Sources:
43NIH Rare Diseases, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
acute leukemia of ambiguous lineage:
Age of onset: Variable


Aliases & Descriptions:

acute biphenotypic leukemia 43 49 31 61
acute leukemia of ambiguous lineage 43 49
acute leukemia of indeterminate lineage 49
acute leukemia of undetermined lineage 43
mixed phenotype acute leukemia 49
mixed lineage acute leukemia 49
aml with lymphoid markers 43
all with myeloid markers 43
hybrid acute leukemia 49
bal 43


External Ids:

MESH via Orphanet36 D015456
ICD10 via Orphanet26 C95.0
SNOMED-CT via Orphanet58 128818009, 278453007, 397345009
UMLS via Orphanet62 C0023464, C1301357

Related Diseases for Acute Biphenotypic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.3MPO, MLLT10, ABL1, KMT2A, NOTCH1, DNTT
2acute myeloid leukemia30.6FLT3, MLLT10
3lymphoblastic lymphoma30.5MPO, NOTCH1, KMT2A, DNTT
4myeloid sarcoma30.3MPO
5acute monocytic leukemia30.3MLLT10, MPO, KMT2A
6precursor b-cell acute lymphoblastic leukemia30.2MPO, DNTT, ABL1, FLT3, KMT2A
7chronic myeloid leukemia30.2ABL1, KMT2A, DNTT, MPO, FLT3
8adenocarcinoma29.8NOTCH1, KMT2A
9mercury poisoning10.5
10essential thrombocythemia10.4
11pulmonary sarcoidosis10.4
12asthma10.4
13lymphoid leukemia10.3
14acute t cell leukemia10.3
15t-cell leukemia10.3
16tetraploidy10.3
17bronchiolitis obliterans10.3
18bronchiolitis10.3
19precursor b lymphoblastic lymphoma/leukemia10.2
20invasive aspergillosis10.2
21arthritis10.2
22aspergillosis10.2
23leukemia, acute pre-b-cell10.2
24pre-b-cell acute lymphoblastic leukemia10.2
25bronchiolitis obliterans organizing pneumonia10.2
26bilineal acute leukemia10.2
27asbestosis10.1
28tuberculosis10.1
29heavy metal poisoning10.1
30nonspecific interstitial pneumonia10.1
31pulmonary tuberculosis10.1
32cystic fibrosis10.1
33idiopathic pulmonary fibrosis10.1
34pulmonary edema10.1
35hemosiderosis10.1
36bronchiectasis10.1
37neuronitis10.1
38bronchitis10.1
39usual interstitial pneumonia10.1
40beryllium disease, chronic10.1
41lymphoblastic leukemia10.0TLX1
42peripheral vascular disease10.0MPO
43wegener's granulomatosis10.0MPO
44hemarthrosis10.0F3
45viral hepatitis10.0F2
46factor xii deficiency10.0F3
47myeloma10.0DNTT, NOTCH1
48acute pancreatitis10.0MPO
49portal vein thrombosis10.0F2
50glioblastoma multiforme10.0ABL1

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Clinical Features for Acute Biphenotypic Leukemia

Drugs & Therapeutics for Acute Biphenotypic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Acute Biphenotypic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Search CenterWatch for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

Anatomical Context for Acute Biphenotypic Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

33
Bone marrow, Breast, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8TLX1, F3, F2, KMT2A
2MP:00053858.0MPO, F3, ABL1, F2, KMT2A, NOTCH1
3MP:00107687.7MPO, F3, ABL1, F2, KMT2A, NOTCH1
4MP:00053767.4FLT3, MPO, F3, ABL1, F2, KMT2A
5MP:00053847.0TLX1, FLT3, DNTT, F3, ABL1, F2
6MP:00053976.8NOTCH1, TLX1, FLT3, MPO, DNTT, F3
7MP:00053876.7TLX1, FLT3, MPO, DNTT, F3, ABL1

Publications for Acute Biphenotypic Leukemia

Sources:
51PubMed
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Articles related to Acute Biphenotypic Leukemia:

(show all 45)
idTitleAuthorsYear
1
Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor I+ Rearrangement. (24416501)
2013
2
Clinical and laboratory features of adult biphenotypic acute leukemia. (22898323)
2013
3
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
4
Lateral pharyngeal wall myeloid sarcoma as a relapse of acute biphenotypic leukemia: a case report and review of the literature. (24377982)
2013
5
Trisomy 7 and deletion of the 9p21 locus as novel acquired abnormalities in a case of pediatric biphenotypic acute leukemia. (22258355)
2012
6
Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. (21151021)
2011
7
Incidence of Philadelphia-chromosome in acute myelogenous leukemia and biphenotypic acute leukemia patients: And its role in their outcome. (21612824)
2011
8
Clinical characteristics, biological profile, and outcome of biphenotypic acute leukemia: a case series. (21266800)
2011
9
Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10. (20299091)
2010
10
A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. (20920256)
2010
11
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
12
Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy. (19752004)
2009
13
Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population. (19454497)
2009
14
Outcomes of CAG regimen for refractory biphenotypic acute leukemia patients. (19848320)
2009
15
Invasive Aspergillus flavus sinusitis: case report in a patient with biphenotypic acute leukemia. (19229393)
2009
16
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. (19380030)
2009
17
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
18
CytCD79a expression in acute leukemia with t(8;21): biphenotypic or myeloid leukemia? (17350472)
2007
19
Nelarabine activity in acute biphenotypic leukemia. (17512588)
2007
20
IgH and TCRgamma gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias. (16102826)
2006
21
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia. (16823822)
2006
22
Arthritis preceding acute biphenotypic leukemia. (16220224)
2006
23
Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (17207092)
2006
24
Acute biphenotypic leukemia and an acquired X chromosome. (15676158)
2005
25
Successful treatment of massive gastrointestinal hemorrhage in acute biphenotypic leukemia with recombinant factor VIIa (NovoSeven). (15060424)
2004
26
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
27
Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. (12953816)
2003
28
Biphenotypic acute leukemia following intensive adjuvant chemotherapy for breast cancer: case report and review of the literature. (12752636)
2003
29
A novel c-kit positive biphenotypic acute leukemia cell line, TMBL-1, carrying a p53 point mutation. (12802925)
2003
30
Acute biphenotypic leukemia in the adults. (12408768)
2002
31
Myeloperoxidase positive acute lymphoblastic leukemia cell lines, NALM-30, NALM-31 and NALM-32, carrying Philadelphia chromosome with biphenotypic characteristics. (10363160)
1998
32
Establishment of a cell line with variant BCR/ABL breakpoint expressing P180BCR/ABL from late-appearing Philadelphia-positive acute biphenotypic leukemia. (9790503)
1998
33
Definition of acute biphenotypic leukemia. (9107085)
1997
34
Trisomy 4 as the sole karyotypic anomaly in acute biphenotypic leukemia with B lineage markers and in acute minimally differentiated myeloid leukemia (M0). (7697636)
1995
35
Lineage commitment in biphenotypic acute leukemia. (8501986)
1993
36
Philadelphia-chromosome-positive, monosomy 7 biphenotypic acute mixed lineage leukemia in adults: a pluripotent stem cell disorder. (7901455)
1993
37
An adult case of acute biphenotypic leukemia with characteristic mixed morphology. (8232165)
1993
38
Granulocyte colony-stimulating factor receptors on human acute leukemia: biphenotypic leukemic cells possess granulocyte colony-stimulating factor receptors. (1534271)
1992
39
Chromosome 21 rearrangement in acute biphenotypic leukemia. (1360869)
1992
40
Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. (1913454)
1991
41
Clinical usefulness of immunocytochemical detection of myeloperoxidase in undifferentiated and biphenotypic acute leukemias. (1666891)
1991
42
Biphenotypic acute leukemia in adults. (1694392)
1990
43
Trisomy 4 in a case of acute biphenotypic leukemia. (2357699)
1990
44
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (2838522)
1988
45
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987

Genetic Variations for Acute Biphenotypic Leukemia

Expression for genes affiliated with Acute Biphenotypic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Biphenotypic Leukemia

Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Acute Biphenotypic Leukemia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1nabumetone45 1111.1MPO, F2
2aprosulate4510.1F3, F2
3napsagatran4510.0F3, F2
4brodifacoum4510.0F3, F2
5hemochron4510.0F3, F2
6certoparin4510.0F3, F2
7appt4510.0F3, F2
8heparin sodium4510.0F3, F2
9inogatran4510.0F3, F2
10ecarin4510.0F3, F2
11dextran 704510.0F3, F2
12polybrene4510.0F3, F2
13spectrozyme4510.0F3, F2
14s-warfarin4510.0F3, F2
15danaparoid4510.0F3, F2
16hepaplastin4510.0F3, F2
17kaolin4510.0F3, F2
18organon4510.0F3, F2
19rivaroxaban45 1110.9F3, F2
20ximelagatran45 1110.9F3, F2
21vitamin k145 2410.9F3, F2
22heparinoids459.9F3, F2
23aminopyrine459.9MPO, F2
24fondaparinux459.9F2, F3
25acenocoumarol45 50 1111.9F2, F3
26naphthol as-d chloroacetate459.9MPO, DNTT
27coumarins459.9F3, F2
28phenprocoumon45 50 1111.8F3, F2
29argatroban45 1110.8F3, F2
30hydroxyethyl starch459.8F3, F2
31ppack459.7F2, F3
32bivalirudin45 1110.7MPO, F3, F2
33tranexamic acid45 1110.7F3, F2
34kininogen459.7F2, F3, MPO
35protamine sulfate459.6F3, F2
36epsilon aminocaproic acid459.6F2, F3
37cytarabine45 50 1111.6FLT3, MPO, ABL1
38tirofiban45 1110.5F2, F3
39Ponatinib 119.3ABL1, FLT3
40nucleoside459.3ABL1, DNTT, FLT3
41af 10459.3TLX1, MLLT10, KMT2A
42lactate459.0FLT3, MPO, DNTT, F2
43dmso458.9MPO, DNTT, F3, ABL1
44vegf458.8FLT3, MPO, F3, ABL1, NOTCH1
45threonine458.8TLX1, FLT3, ABL1, KMT2A, NOTCH1
46oligonucleotide458.6TLX1, FLT3, DNTT, ABL1, KMT2A
47zinc45 249.1TLX1, MLLT10, DNTT, ABL1, KMT2A
48retinoic acid45 249.0NOTCH1, KMT2A, ABL1, F3, DNTT, MPO
49aspartate457.9NOTCH1, KMT2A, F2, ABL1, F3, DNTT
50serine457.9MPO, DNTT, F3, ABL1, F2, KMT2A

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:0082848.6NOTCH1, F2, FLT3, TLX1
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.5NOTCH1, KMT2A, MLLT10, TLX1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.8NOTCH1, KMT2A, F2, ABL1, F3, MLLT10

Products for genes affiliated with Acute Biphenotypic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Biphenotypic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet