BAL
MCID: ACT095
MIFTS: 56

Acute Biphenotypic Leukemia (BAL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Acute Biphenotypic Leukemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards: Acute Biphenotypic Leukemia, also known as acute leukemia of ambiguous lineage, is related to leukemia and acute leukemia. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds aprosulate and napsagatran have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and monocytes, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Acute Biphenotypic Leukemia

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43NIH Rare Diseases, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
acute leukemia of ambiguous lineage:
Age of onset: Variable


Aliases & Descriptions:

acute biphenotypic leukemia 43 49 31 62
acute leukemia of ambiguous lineage 43 49
acute undifferentiated leukemia 45 49
mixed phenotype acute leukemia 43 49
mixed lineage acute leukemia 43 49
hybrid acute leukemia 43 49
acute leukemia of indeterminate lineage 49
acute leukemia of undetermined lineage 43
undifferentiated acute leukemia 43
biphenotypic acute leukemia 43
aml with lymphoid markers 43
all with myeloid markers 43
bal 43


External Ids:

MESH via Orphanet36 D015456
ICD10 via Orphanet26 C95.0
SNOMED-CT via Orphanet59 128818009, 278453007, 397345009
UMLS via Orphanet63 C0023464, C1301357, C0856823

Related Diseases for Acute Biphenotypic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0ABL1, MLLT10, TLX1, MPO, KMT2A, FLT3
2acute leukemia30.7ABL1, MLLT10, MPO, KMT2A, FLT3, DNTT
3lymphoblastic lymphoma30.5MPO, KMT2A, DNTT, NOTCH1
4lymphoblastic leukemia30.5TLX1
5myeloid sarcoma30.5MPO
6myeloid leukemia30.4ABL1, MLLT10, MPO, KMT2A, FLT3, DNTT
7chronic myeloid leukemia30.2ABL1, MPO, KMT2A, FLT3, DNTT
8peritonitis30.1F2, MPO
9precursor t-cell acute lymphoblastic leukemia30.0NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A
10sarcoidosis10.6
11mercury poisoning10.5
12pneumonia10.5
13essential thrombocythemia10.5
14pulmonary sarcoidosis10.4
15tetraploidy10.4
16asthma10.3
17pulmonary fibrosis10.3
18bronchiolitis10.3
19bronchiolitis obliterans10.3
20pharyngitis10.2
21acute myeloid leukemia10.2
22arthritis10.2
23aspergillosis10.2
24breast cancer10.2
25multiple myeloma10.2
26myeloma10.2
27sarcoma10.2
28sinusitis10.2
29acute myeloid leukemia with npm1 somatic mutations10.2
30thymoma10.2
31acute erythroblastic leukemia10.2
32glucocorticoid resistance10.2
33bilineal acute leukemia10.2
34bronchiolitis obliterans organizing pneumonia10.1
35asbestosis10.1
36eosinophilic pneumonia10.1
37extrinsic allergic alveolitis10.1
38interstitial lung disease10.1
39tuberculosis10.1
40heavy metal poisoning10.1
41factor xii deficiency10.1F3
42peripheral vascular disease10.1MPO
43leukemia, acute nonlymphocytic10.1KMT2A, DNTT
44monocytic leukemia10.1F3, KMT2A
45megakaryocytic leukemia10.1MPO, KMT2A
46cystic fibrosis10.1
47pulmonary tuberculosis10.1
48nonspecific interstitial pneumonia10.1
49bronchiectasis10.1
50neuronitis10.1

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Symptoms for Acute Biphenotypic Leukemia

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Drugs & Therapeutics for Acute Biphenotypic Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

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Anatomical Context for Acute Biphenotypic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

33
Myeloid, Bone, Monocytes, T cells

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1NOTCH1, F3, FLT3, KMT2A
2MP:00053698.6ABL1, MPO, KMT2A, F3, NOTCH1
3MP:00053858.2F2, ABL1, MPO, KMT2A, F3, NOTCH1
4MP:00053808.1F2, ABL1, TLX1, KMT2A, F3, NOTCH1
5MP:00028738.0F2, ABL1, F3, DNTT, NOTCH1
6MP:00036317.9F2, ABL1, TLX1, KMT2A, F3, NOTCH1
7MP:00053767.9F2, ABL1, MPO, KMT2A, FLT3, F3
8MP:00053787.8F2, ABL1, KMT2A, FLT3, F3, NOTCH1
9MP:00107687.8F2, ABL1, MPO, KMT2A, FLT3, F3
10MP:00053847.8F2, ABL1, TLX1, KMT2A, FLT3, F3
11MP:00053976.9NOTCH1, F2, ABL1, TLX1, MPO, KMT2A
12MP:00053876.8F2, ABL1, TLX1, MPO, KMT2A, FLT3

Publications for Acute Biphenotypic Leukemia

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52PubMed
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Articles related to Acute Biphenotypic Leukemia:

(show all 25)
idTitleAuthorsYear
1
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
2
Lateral pharyngeal wall myeloid sarcoma as a relapse of acute biphenotypic leukemia: a case report and review of the literature. (24377982)
2013
3
Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. (21151021)
2011
4
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
5
Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy. (19752004)
2009
6
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. (19380030)
2009
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Nelarabine activity in acute biphenotypic leukemia. (17512588)
2007
9
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia. (16823822)
2006
10
Arthritis preceding acute biphenotypic leukemia. (16220224)
2006
11
Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (17207092)
2006
12
Acute biphenotypic leukemia and an acquired X chromosome. (15676158)
2005
13
Successful treatment of massive gastrointestinal hemorrhage in acute biphenotypic leukemia with recombinant factor VIIa (NovoSeven). (15060424)
2004
14
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
15
Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. (12953816)
2003
16
Acute biphenotypic leukemia in the adults. (12408768)
2002
17
Establishment of a cell line with variant BCR/ABL breakpoint expressing P180BCR/ABL from late-appearing Philadelphia-positive acute biphenotypic leukemia. (9790503)
1998
18
Definition of acute biphenotypic leukemia. (9107085)
1997
19
Trisomy 4 as the sole karyotypic anomaly in acute biphenotypic leukemia with B lineage markers and in acute minimally differentiated myeloid leukemia (M0). (7697636)
1995
20
An adult case of acute biphenotypic leukemia with characteristic mixed morphology. (8232165)
1993
21
Chromosome 21 rearrangement in acute biphenotypic leukemia. (1360869)
1992
22
Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. (1913454)
1991
23
Trisomy 4 in a case of acute biphenotypic leukemia. (2357699)
1990
24
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (2838522)
1988
25
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987

Variations for Acute Biphenotypic Leukemia

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Expression for genes affiliated with Acute Biphenotypic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Biphenotypic Leukemia

Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 54R&D Systems
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Pathways related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.7F3, F2
2
Show member pathways
9.7F3, F2
39.0FLT3, KMT2A, MPO, TLX1

Compounds for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1aprosulate4510.2F2, F3
2napsagatran4510.2F2, F3
3brodifacoum4510.2F2, F3
4mnpt4510.2F2, F3
5certoparin4510.1F2, F3
6appt4510.1F2, F3
7hemochron4510.1F2, F3
8inogatran4510.1F3, F2
9heparin sodium4510.1F3, F2
10dextran 704510.1F2, F3
11ecarin4510.1F2, F3
12polybrene4510.1F2, F3
13spectrozyme4510.1F2, F3
14s-warfarin4510.1F2, F3
15danaparoid4510.1F2, F3
16hepaplastin4510.1F2, F3
17nabumetone45 1111.1F2, MPO
18rivaroxaban45 1111.1F2, F3
19kaolin4510.1F2, F3
20ximelagatran45 1111.1F2, F3
21organon4510.0F2, F3
22vitamin k145 2411.0F2, F3
23heparinoids4510.0F2, F3
24fondaparinux4510.0F3, F2
25acenocoumarol45 51 1112.0F3, F2
26phenprocoumon45 51 1111.9F2, F3
27coumarins459.9F2, F3
28hydroxyethyl starch459.9F2, F3
29naphthol as-d chloroacetate459.8MPO, DNTT
30aminopyrine459.8F2, MPO
31argatroban45 1110.8F2, F3
32bivalirudin45 1110.8F2, MPO, F3
33ppack459.8F3, F2
34kininogen459.7F3, MPO, F2
35tranexamic acid45 1110.7F2, F3
36protamine sulfate459.6F2, F3
37cytarabine45 51 1111.5ABL1, MPO, FLT3
38tirofiban45 1110.4F3, F2
39nucleoside459.3DNTT, FLT3, ABL1
40af 10459.3KMT2A, TLX1, MLLT10
41phosphatidylserine45 29 1111.2F3, ABL1, F2
42dmso459.1ABL1, MPO, F3, DNTT
43lactate459.0F2, MPO, FLT3, DNTT
44vegf458.9ABL1, MPO, FLT3, F3, NOTCH1
45threonine458.7ABL1, TLX1, KMT2A, FLT3, NOTCH1
46oligonucleotide458.6ABL1, TLX1, KMT2A, FLT3, DNTT
47zinc45 249.1ABL1, MLLT10, TLX1, KMT2A, DNTT
48retinoic acid45 249.0ABL1, MPO, KMT2A, FLT3, F3, DNTT
49aspartate457.9NOTCH1, F2, ABL1, KMT2A, FLT3, F3
50serine457.9F2, ABL1, MPO, KMT2A, F3, DNTT

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

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16Gene Ontology
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Cellular components related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.4NOTCH1, F3, FLT3
2nucleusGO:0056346.6NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A

Biological processes related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4FLT3, F2
2negative regulation of cell proliferationGO:0082859.4NOTCH1, FLT3, KMT2A
3positive regulation of cell proliferationGO:0082848.8NOTCH1, FLT3, TLX1, F2
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.3MLLT10, TLX1, KMT2A, NOTCH1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037008.4MLLT10, TLX1, KMT2A, NOTCH1
2protein bindingGO:0055156.5F2, ABL1, MLLT10, TLX1, KMT2A, FLT3

Products for genes affiliated with Acute Biphenotypic Leukemia

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  • Antibodies
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Sources for Acute Biphenotypic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet