BAL
MCID: ACT095
MIFTS: 55

Acute Biphenotypic Leukemia (BAL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Acute Biphenotypic Leukemia

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Wikipedia:65 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards based summary: Acute Biphenotypic Leukemia, also known as acute undifferentiated leukemia, is related to lymphoblastic leukemia and myeloid sarcoma. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds aprosulate and napsagatran have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and monocytes, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Acute Biphenotypic Leukemia

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Acute Biphenotypic Leukemia, Aliases & Descriptions:

Name: Acute Biphenotypic Leukemia 30 42 48 62
Acute Undifferentiated Leukemia 44 48 62
Acute Leukemia of Ambiguous Lineage 42 62
Undifferentiated Acute Leukemia 42 62
Biphenotypic Acute Leukemia 42 62
Hybrid Acute Leukemia 42 62
Acute Leukemia of Undetermined Lineage 42
 
Mixed Phenotype Acute Leukaemia 62
Mixed Phenotype Acute Leukemia 42
Mixed Lineage Acute Leukemia 42
Mixed-Lineage Acute Leukemia 62
Aml with Lymphoid Markers 42
All with Myeloid Markers 42
Bal 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

MESH via Orphanet35 D015456
ICD10 via Orphanet26 C95.0
UMLS via Orphanet63 C0023464, C0856823

Related Diseases for Acute Biphenotypic Leukemia

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Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia31.2TLX1
2myeloid sarcoma31.0MPO
3lymphoblastic lymphoma30.5MPO, KMT2A, DNTT, NOTCH1
4peritonitis30.3F2, MPO
5leukemia30.0ABL1, MLLT10, TLX1, MPO, KMT2A, FLT3
6acute leukemia29.8ABL1, MLLT10, MPO, KMT2A, FLT3, DNTT
7myeloid leukemia29.8ABL1, MLLT10, MPO, KMT2A, FLT3, DNTT
8chronic myeloid leukemia29.7ABL1, MPO, KMT2A, FLT3, DNTT
9acute lymphoblastic leukemia29.1ABL1, MLLT10, MPO, KMT2A, FLT3, DNTT
10precursor t-cell acute lymphoblastic leukemia28.9NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A
11sarcoidosis10.6
12mercury poisoning10.6
13pneumonia10.5
14factor xii deficiency10.5F3
15peripheral vascular disease10.4MPO
16pulmonary sarcoidosis10.4
17essential thrombocythemia10.4
18lymphoid leukemia10.4
19tetraploidy10.4
20leukemia, acute nonlymphocytic10.3KMT2A, DNTT
21monocytic leukemia10.3F3, KMT2A
22asthma10.3
23pulmonary fibrosis10.3
24megakaryocytic leukemia10.3MPO, KMT2A
25bronchiolitis obliterans10.3
26bronchiolitis10.3
27factor x deficiency10.2F3, F2
28acute myeloid leukemia10.2
29arthritis10.2
30multiple myeloma10.2
31sinusitis10.2
32pharyngitis10.2
33aspergillosis10.2
34breast cancer10.2
35myeloma10.2
36sarcoma10.2
37factor v deficiency10.2F2, F3
38vitamin k deficiency hemorrhagic disease10.2F2, F3
39factor xi deficiency10.2F2, F3
40acute myeloid leukemia, adult10.2FLT3, KMT2A
41protein s deficiency10.2F2, F3
42hemorrhagic disease10.2F2, F3
43von willebrand's disease10.2F2, F3
44factor vii deficiency10.2F2, F3
45eosinophilic pneumonia10.2
46afibrinogenemia10.2F3, F2
47factor viii deficiency10.2F3, F2
48hemophilia b10.2F2, F3
49pulmonary embolism10.2F3, F2
50pregnancy loss10.2F3, F2

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Symptoms for Acute Biphenotypic Leukemia

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Drugs & Therapeutics for Acute Biphenotypic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

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Anatomical Context for Acute Biphenotypic Leukemia

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MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

32
Myeloid, Bone, Monocytes, T cells

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1NOTCH1, F3, FLT3, KMT2A
2MP:00053698.6ABL1, MPO, KMT2A, F3, NOTCH1
3MP:00053858.2F2, ABL1, MPO, KMT2A, F3, NOTCH1
4MP:00053808.1F2, ABL1, TLX1, KMT2A, F3, NOTCH1
5MP:00028738.0F2, ABL1, F3, DNTT, NOTCH1
6MP:00036317.9F2, ABL1, TLX1, KMT2A, F3, NOTCH1
7MP:00053767.9F2, ABL1, MPO, KMT2A, FLT3, F3
8MP:00053787.8F2, ABL1, KMT2A, FLT3, F3, NOTCH1
9MP:00107687.8F2, ABL1, MPO, KMT2A, FLT3, F3
10MP:00053847.8F2, ABL1, TLX1, KMT2A, FLT3, F3
11MP:00053976.9NOTCH1, F2, ABL1, TLX1, MPO, KMT2A
12MP:00053876.8F2, ABL1, TLX1, MPO, KMT2A, FLT3

Publications for Acute Biphenotypic Leukemia

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Articles related to Acute Biphenotypic Leukemia:

(show all 24)
idTitleAuthorsYear
1
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
2
Lateral pharyngeal wall myeloid sarcoma as a relapse of acute biphenotypic leukemia: a case report and review of the literature. (24377982)
2013
3
Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. (21151021)
2011
4
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
5
Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy. (19752004)
2009
6
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. (19380030)
2009
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Nelarabine activity in acute biphenotypic leukemia. (17512588)
2007
9
Arthritis preceding acute biphenotypic leukemia. (16220224)
2006
10
Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (17207092)
2006
11
Acute biphenotypic leukemia and an acquired X chromosome. (15676158)
2005
12
Successful treatment of massive gastrointestinal hemorrhage in acute biphenotypic leukemia with recombinant factor VIIa (NovoSeven). (15060424)
2004
13
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
14
Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. (12953816)
2003
15
Acute biphenotypic leukemia in the adults. (12408768)
2002
16
Establishment of a cell line with variant BCR/ABL breakpoint expressing P180BCR/ABL from late-appearing Philadelphia-positive acute biphenotypic leukemia. (9790503)
1998
17
Definition of acute biphenotypic leukemia. (9107085)
1997
18
Trisomy 4 as the sole karyotypic anomaly in acute biphenotypic leukemia with B lineage markers and in acute minimally differentiated myeloid leukemia (M0). (7697636)
1995
19
An adult case of acute biphenotypic leukemia with characteristic mixed morphology. (8232165)
1993
20
Chromosome 21 rearrangement in acute biphenotypic leukemia. (1360869)
1992
21
Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. (1913454)
1991
22
Trisomy 4 in a case of acute biphenotypic leukemia. (2357699)
1990
23
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (2838522)
1988
24
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987

Variations for Acute Biphenotypic Leukemia

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Expression for genes affiliated with Acute Biphenotypic Leukemia

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Expression patterns in normal tissues for genes affiliated with Acute Biphenotypic Leukemia

Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

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Pathways related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.7F3, F2
2
Show member pathways
9.7F3, F2
39.0FLT3, KMT2A, MPO, TLX1

Compounds for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
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Compounds related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1aprosulate4410.2F2, F3
2napsagatran4410.2F2, F3
3brodifacoum4410.2F2, F3
4mnpt4410.2F2, F3
5certoparin4410.1F2, F3
6appt4410.1F2, F3
7hemochron4410.1F2, F3
8inogatran4410.1F3, F2
9heparin sodium4410.1F3, F2
10dextran 704410.1F2, F3
11ecarin4410.1F2, F3
12polybrene4410.1F2, F3
13spectrozyme4410.1F2, F3
14s-warfarin4410.1F2, F3
15danaparoid4410.1F2, F3
16hepaplastin4410.1F2, F3
17nabumetone44 1111.1F2, MPO
18rivaroxaban44 1111.1F2, F3
19kaolin4410.1F2, F3
20ximelagatran44 1111.1F2, F3
21organon4410.0F2, F3
22vitamin k144 2411.0F2, F3
23heparinoids4410.0F2, F3
24fondaparinux4410.0F3, F2
25acenocoumarol44 50 1112.0F3, F2
26phenprocoumon44 50 1111.9F2, F3
27coumarins449.9F2, F3
28hydroxyethyl starch449.9F2, F3
29naphthol as-d chloroacetate449.8MPO, DNTT
30aminopyrine449.8F2, MPO
31argatroban44 1110.8F2, F3
32bivalirudin44 1110.8F2, MPO, F3
33ppack449.8F3, F2
34kininogen449.7F3, MPO, F2
35tranexamic acid44 1110.7F2, F3
36protamine sulfate449.6F2, F3
37cytarabine44 50 1111.5ABL1, MPO, FLT3
38tirofiban44 1110.4F3, F2
39nucleoside449.3DNTT, FLT3, ABL1
40af 10449.3KMT2A, TLX1, MLLT10
41phosphatidylserine44 28 1111.2F3, ABL1, F2
42dmso449.1ABL1, MPO, F3, DNTT
43lactate449.0F2, MPO, FLT3, DNTT
44vegf448.9ABL1, MPO, FLT3, F3, NOTCH1
45threonine448.7ABL1, TLX1, KMT2A, FLT3, NOTCH1
46oligonucleotide448.6ABL1, TLX1, KMT2A, FLT3, DNTT
47zinc44 249.1ABL1, MLLT10, TLX1, KMT2A, DNTT
48retinoic acid44 249.0ABL1, MPO, KMT2A, FLT3, F3, DNTT
49aspartate447.9NOTCH1, F2, ABL1, KMT2A, FLT3, F3
50serine447.9F2, ABL1, MPO, KMT2A, F3, DNTT

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

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Cellular components related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.4NOTCH1, F3, FLT3
2nucleusGO:0056346.6NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A

Biological processes related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4FLT3, F2
2negative regulation of cell proliferationGO:0082859.4NOTCH1, FLT3, KMT2A
3positive regulation of cell proliferationGO:0082848.8NOTCH1, FLT3, TLX1, F2
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.3MLLT10, TLX1, KMT2A, NOTCH1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037008.4NOTCH1, KMT2A, TLX1, MLLT10
2protein bindingGO:0055156.5NOTCH1, F2, ABL1, MLLT10, TLX1, KMT2A

Products for genes affiliated with Acute Biphenotypic Leukemia

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Sources for Acute Biphenotypic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet