MCID: ACT095
MIFTS: 49

Acute Biphenotypic Leukemia malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Aliases & Classifications for Acute Biphenotypic Leukemia

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Acute Biphenotypic Leukemia:

Name: Acute Biphenotypic Leukemia 30 42 48 61
Acute Undifferentiated Leukemia 44 48 61
Acute Leukemia of Ambiguous Lineage 42 61
B-Cell Prolymphocytic Leukemia 42 48
Mixed Phenotype Acute Leukemia 42 61
B-Pll 42 48
Acute Leukemia of Undetermined Lineage 42
Leukemia, Prolymphocytic, B-Cell 61
Undifferentiated Acute Leukemia 42
 
Leukemia, B Cell Prolymphocytic 42
B Cell Prolymphocytic Leukemia 42
Mixed Lineage Acute Leukemia 42
Biphenotypic Acute Leukemia 42
Aml with Lymphoid Markers 42
All with Myeloid Markers 42
Hybrid Acute Leukemia 42
Bal 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
b-cell prolymphocytic leukemia:
Age of onset: Adult


External Ids:

Orphanet48 86852, 98837, 98835
MESH via Orphanet34 D054403, D015456
ICD10 via Orphanet26 C91.3, C95.0
UMLS via Orphanet62 C0475801, C0023464, C0856823
ICD1025 C91.3

Summaries for Acute Biphenotypic Leukemia

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Wikipedia:64 Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid... more...

MalaCards based summary: Acute Biphenotypic Leukemia, also known as acute undifferentiated leukemia, is related to lymphoblastic leukemia and myeloid sarcoma. An important gene associated with Acute Biphenotypic Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds aprosulate and mnpt have been mentioned in the context of this disorder. Affiliated tissues include b cells, myeloid and bone, and related mouse phenotypes are tumorigenesis and muscle.

Related Diseases for Acute Biphenotypic Leukemia

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Diseases related to Acute Biphenotypic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia31.2TLX1
2myeloid sarcoma31.0MPO
3lymphoblastic lymphoma30.5KMT2A, DNTT, MPO, NOTCH1
4chronic lymphocytic leukemia30.4FLT3, KMT2A, ABL1, DNTT
5peritonitis30.3F2, MPO
6leukemia30.0MLLT10, ABL1, NOTCH1, DNTT, FLT3, MPO
7acute leukemia29.8FLT3, DNTT, NOTCH1, ABL1, MLLT10, KMT2A
8myeloid leukemia29.7FLT3, DNTT, KMT2A, MPO, MLLT10, ABL1
9precursor t-cell acute lymphoblastic leukemia28.9TLX1, NOTCH1, DNTT, KMT2A, MPO, MLLT10
10prolymphocytic leukemia11.1
11mercury poisoning10.6
12pneumonia10.5
13essential thrombocythemia10.5
14factor xiii deficiency10.5F3
15meningitis10.5
16factor xii deficiency10.5F3
17factor viii deficiency10.5F3
18peripheral vascular disease10.4MPO
19pulmonary sarcoidosis10.4
20lymphoid leukemia10.4
21tetraploidy10.4
22monocytic leukemia10.3KMT2A, F3
23pulmonary fibrosis10.3
24hematopoietic stem cell transplantation10.3
25hemolytic anemia10.3
26mantle cell lymphoma10.3
27pure red-cell aplasia10.3
28autoimmune hemolytic anemia10.3
29hypercalcemia10.3
30polyradiculoneuropathy10.3
31asthma10.3
32bronchiolitis obliterans10.3
33bronchiolitis10.3
34megakaryocytic leukemia10.3MPO, KMT2A
35breast cancer10.2
36aspergillosis10.2
37multiple myeloma10.2
38arthritis10.2
39sinusitis10.2
40pharyngitis10.2
41myeloma10.2
42sarcoma10.2
43factor x deficiency10.2F2, F3
44factor v deficiency10.2F3, F2
45vitamin k deficiency hemorrhagic disease10.2F2, F3
46factor xi deficiency, autosomal recessive10.2F3, F2
47eosinophilic pneumonia10.2
48acute myeloid leukemia, adult10.2KMT2A, FLT3
49protein s deficiency10.2F2, F3
50hemorrhagic disease10.2F3, F2

Graphical network of the top 20 diseases related to Acute Biphenotypic Leukemia:



Diseases related to acute biphenotypic leukemia

Symptoms for Acute Biphenotypic Leukemia

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Drugs & Therapeutics for Acute Biphenotypic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Biphenotypic Leukemia

Search NIH Clinical Center for Acute Biphenotypic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Biphenotypic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Biphenotypic Leukemia

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Anatomical Context for Acute Biphenotypic Leukemia

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MalaCards organs/tissues related to Acute Biphenotypic Leukemia:

31
B cells, Myeloid, Bone, Monocytes, T cells

Animal Models for Acute Biphenotypic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Biphenotypic Leukemia:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1NOTCH1, F3, FLT3, KMT2A
2MP:00053698.6ABL1, KMT2A, MPO, F3, NOTCH1
3MP:00053858.2ABL1, F3, KMT2A, MPO, F2, NOTCH1
4MP:00053808.1NOTCH1, KMT2A, TLX1, ABL1, F2, F3
5MP:00028738.0F2, ABL1, NOTCH1, F3, DNTT
6MP:00036317.9KMT2A, NOTCH1, TLX1, ABL1, F2, F3
7MP:00053767.9F2, MPO, F3, NOTCH1, ABL1, KMT2A
8MP:00053787.8ABL1, F3, F2, NOTCH1, KMT2A, FLT3
9MP:00107687.8MPO, ABL1, KMT2A, FLT3, F2, NOTCH1
10MP:00053847.8FLT3, F2, ABL1, TLX1, KMT2A, F3
11MP:00053976.9MPO, ABL1, TLX1, KMT2A, F2, FLT3
12MP:00053876.8TLX1, F2, MPO, FLT3, F3, ABL1

Publications for Acute Biphenotypic Leukemia

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Articles related to Acute Biphenotypic Leukemia:

(show all 25)
idTitleAuthorsYear
1
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
2
Lateral pharyngeal wall myeloid sarcoma as a relapse of acute biphenotypic leukemia: a case report and review of the literature. (24377982)
2013
3
Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. (21151021)
2011
4
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
5
Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy. (19752004)
2009
6
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. (19380030)
2009
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Nelarabine activity in acute biphenotypic leukemia. (17512588)
2007
9
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia. (16823822)
2006
10
Arthritis preceding acute biphenotypic leukemia. (16220224)
2006
11
Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (17207092)
2006
12
Acute biphenotypic leukemia and an acquired X chromosome. (15676158)
2005
13
Successful treatment of massive gastrointestinal hemorrhage in acute biphenotypic leukemia with recombinant factor VIIa (NovoSeven). (15060424)
2004
14
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
15
Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. (12953816)
2003
16
Acute biphenotypic leukemia in the adults. (12408768)
2002
17
Establishment of a cell line with variant BCR/ABL breakpoint expressing P180BCR/ABL from late-appearing Philadelphia-positive acute biphenotypic leukemia. (9790503)
1998
18
Definition of acute biphenotypic leukemia. (9107085)
1997
19
Trisomy 4 as the sole karyotypic anomaly in acute biphenotypic leukemia with B lineage markers and in acute minimally differentiated myeloid leukemia (M0). (7697636)
1995
20
An adult case of acute biphenotypic leukemia with characteristic mixed morphology. (8232165)
1993
21
Chromosome 21 rearrangement in acute biphenotypic leukemia. (1360869)
1992
22
Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. (1913454)
1991
23
Trisomy 4 in a case of acute biphenotypic leukemia. (2357699)
1990
24
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (2838522)
1988
25
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987

Variations for Acute Biphenotypic Leukemia

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Expression for genes affiliated with Acute Biphenotypic Leukemia

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Search GEO for disease gene expression data for Acute Biphenotypic Leukemia.

Pathways for genes affiliated with Acute Biphenotypic Leukemia

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Pathways related to Acute Biphenotypic Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.7F3, F2
2
Show member pathways
9.7F3, F2
39.0FLT3, KMT2A, MPO, TLX1

Compounds for genes affiliated with Acute Biphenotypic Leukemia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Acute Biphenotypic Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1aprosulate4410.2F3, F2
2mnpt4410.2F3, F2
3napsagatran4410.2F2, F3
4brodifacoum4410.2F3, F2
5appt4410.1F3, F2
6certoparin4410.1F2, F3
7hemochron4410.1F2, F3
8heparin sodium4410.1F3, F2
9inogatran4410.1F2, F3
10dextran 704410.1F2, F3
11ecarin4410.1F3, F2
12spectrozyme4410.1F2, F3
13polybrene4410.1F2, F3
14danaparoid4410.1F3, F2
15hepaplastin4410.1F2, F3
16s-warfarin4410.1F2, F3
17nabumetone44 1111.1F2, MPO
18kaolin4410.1F3, F2
19organon4410.1F3, F2
20ximelagatran44 1111.1F3, F2
21rivaroxaban44 1111.0F3, F2
22vitamin k144 2411.0F2, F3
23heparinoids4410.0F3, F2
24fondaparinux4410.0F2, F3
25acenocoumarol44 50 1112.0F3, F2
26argatroban44 1110.9F2, F3
27aminopyrine449.9MPO, F2
28hydroxyethyl starch449.9F2, F3
29coumarins449.9F3, F2
30naphthol as-d chloroacetate449.8DNTT, MPO
31phenprocoumon44 50 1111.8F3, F2
32bivalirudin44 1110.8F3, MPO, F2
33ppack449.8F2, F3
34kininogen449.7MPO, F3, F2
35tranexamic acid44 1110.7F2, F3
36protamine sulfate449.6F3, F2
37cytarabine44 50 1111.5ABL1, FLT3, MPO
38tirofiban44 1110.4F2, F3
39nucleoside449.3DNTT, FLT3, ABL1
40af 10449.3TLX1, MLLT10, KMT2A
41phosphatidylserine44 28 1111.2F3, F2, ABL1
42dmso449.1DNTT, MPO, ABL1, F3
43lactate449.0DNTT, F2, MPO, FLT3
44vegf448.9FLT3, ABL1, F3, NOTCH1, MPO
45threonine448.7NOTCH1, FLT3, ABL1, KMT2A, TLX1
46oligonucleotide448.6TLX1, KMT2A, FLT3, DNTT, ABL1
47zinc44 249.1TLX1, DNTT, KMT2A, MLLT10, ABL1
48retinoic acid44 249.0DNTT, MPO, ABL1, NOTCH1, KMT2A, F3
49aspartate447.9FLT3, KMT2A, ABL1, F2, F3, DNTT
50serine447.9KMT2A, ABL1, F2, F3, DNTT, NOTCH1

GO Terms for genes affiliated with Acute Biphenotypic Leukemia

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Cellular components related to Acute Biphenotypic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.4NOTCH1, F3, FLT3
2nucleusGO:00056346.6NOTCH1, ABL1, MLLT10, TLX1, MPO, KMT2A

Biological processes related to Acute Biphenotypic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.4FLT3, F2
2negative regulation of cell proliferationGO:00082859.4NOTCH1, FLT3, KMT2A
3positive regulation of cell proliferationGO:00082848.8NOTCH1, FLT3, TLX1, F2
4positive regulation of transcription from RNA polymerase II promoterGO:00459448.3MLLT10, TLX1, KMT2A, NOTCH1

Molecular functions related to Acute Biphenotypic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00037008.4NOTCH1, KMT2A, TLX1, MLLT10
2protein bindingGO:00055156.5NOTCH1, F2, ABL1, MLLT10, TLX1, KMT2A

Sources for Acute Biphenotypic Leukemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet