MCID: ACT017
MIFTS: 48

Acute Chest Syndrome malady

Categories: Respiratory diseases

Aliases & Classifications for Acute Chest Syndrome

Aliases & Descriptions for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 52 42 14 69
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 35 517.3
MeSH 42 D056586
SNOMED-CT 64 372146004
UMLS 69 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and 7q11.23 duplication syndrome, and has symptoms including fever, pleuritic chest pain and tachypnea. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Menthol and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and neutrophil, and related phenotype is cardiovascular system.

Wikipedia : 71 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 sickle cell disease 10.6
2 7q11.23 duplication syndrome 10.2 NOS1 NOS3
3 psychosexual disorder 10.2 NOS1 NOS3
4 vitreous disease 10.2 CXCL8 NOS3
5 gastroduodenal crohn's disease 10.2 NOS1 NOS3
6 sickle cell anemia 10.2
7 proliferating trichilemmal cyst 10.1 EDN1 NOS3
8 indeterminate leprosy 10.1 EDN1 NOS3
9 ectodermal dysplasia 9, hair/nail type 10.1 EDN1 NOS3
10 aplasia cutis congenita recessive 10.1 EDN1 NOS3
11 esophagus lymphoma 10.1 CXCL8 EDN1
12 asthma 10.1
13 traumatic glaucoma 10.1 EDN1 NOS3
14 hepatic infarction 10.1 EDN1 HBB
15 lymphadenitis 10.1 EDN1 NOS3
16 erb-duchenne and dejerine-klumpke palsies 10.0 CXCL8 VCAM1
17 microglandular adenosis of breast 10.0 CXCL8 IL1A
18 splenic marginal zone lymphoma 10.0 CXCL8 NOS1 PLA2G2A
19 pyelonephritis 10.0 CXCL8 EDN1 NOS3
20 limb ischemia 10.0 CXCL8 EDN1 NOS3
21 diabetic encephalopathy 10.0 CXCL8 EDN1 NOS3
22 stomach carcinoma in situ 10.0 CXCL8 IL1A
23 aphasia 10.0 EDN1 NOS1 NOS3
24 zellweger syndrome 10.0 EDN1 NOS3
25 viral hepatitis 10.0 EDN1 NOS1 NOS3
26 welander distal myopathy 10.0 EDN1 NOS3 VCAM1
27 mucinous ovarian cystadenoma 10.0 EDN1 NOS1 NOS3
28 sclerosing cholangitis 10.0 CXCL8 IL1A
29 lymphedema 10.0 IL1A VCAM1
30 poikiloderma with neutropenia 10.0 EDN1 NOS3
31 pyrimidine metabolic disorder 10.0 EDN1 NOS3 VCAM1
32 limbal stem cell deficiency 9.9 IL1A VCAM1
33 autoimmune-related retinopathy and optic neuropathy 9.9 EDN1 NOS3 VCAM1
34 contact lens corneal edema 9.9 CXCL8 IL1A
35 autosomal recessive type iv ehlers-danlos syndrome 9.9 CXCL8 IL1A
36 pericarditis 9.9 EDN1 NOS3 VCAM1
37 alpha-2-plasmin inhibitor deficiency 9.9 EDN1 NOS3
38 bare lymphocyte syndrome, type i 9.9 CXCL8 IL1A VCAM1
39 plastic bronchitis 9.8
40 pneumonia 9.8
41 bronchitis 9.8
42 nervous system cancer 9.8 CXCL8 EDN1 IL1A
43 thalassemia 9.7
44 ischemia 9.7
45 cerebritis 9.7
46 pulmonary hypertension 9.6
47 thrombosis 9.6
48 endotheliitis 9.6
49 chlamydia 9.6
50 aortic aneurysm, familial thoracic 6 9.6 CXCL8 EDN1 IL1A VCAM1

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

Symptoms:

12
  • fever
  • pleuritic chest pain
  • tachypnea
  • cough
  • hypoxemia
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

UMLS symptoms related to Acute Chest Syndrome:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness

MGI Mouse Phenotypes related to Acute Chest Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 EDN1 IL1A NOS1 NOS3 PLA2G10 VCAM1

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 426)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Clonidine Approved Phase 4 4205-90-7 2803
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
7
Ramipril Approved Phase 4 87333-19-5 5362129
8
Ticagrelor Approved Phase 4,Phase 3,Phase 1 274693-27-5 9871419
9
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
10
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
11
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
13
Tirofiban Approved Phase 4,Phase 3,Phase 2 144494-65-5 60947
14
Allopurinol Approved Phase 4,Phase 2 315-30-0 2094
15
Isosorbide Dinitrate Approved Phase 4,Early Phase 1 87-33-2 6883
16
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 10102-43-9 145068
17
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
18
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
22
Abciximab Approved Phase 4 143653-53-6
23
Everolimus Approved Phase 4,Phase 3,Phase 2,Early Phase 1 159351-69-6 6442177
24
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
25
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
26
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
27
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 53123-88-9 5284616 6436030 46835353
28
Paclitaxel Approved, Vet_approved Phase 4,Phase 3 33069-62-4 36314
29
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
30
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
31
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
32
Dalteparin Approved Phase 4,Phase 3,Phase 2 9041-08-1
33
Cangrelor Approved Phase 4 163706-06-7 9854012
34
Warfarin Approved Phase 4 81-81-2 6691 54678486
35
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
36
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
37
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
38
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
39
Menadione Approved, Nutraceutical Phase 4,Phase 3 58-27-5 4055
40
Phytonadione Approved, Nutraceutical Phase 4,Phase 3 84-80-0 4812 5284607
41 Calcium, Dietary Phase 4,Phase 3,Phase 2
42 Cisatracurium Phase 4,Phase 3
43 Neuromuscular Agents Phase 4
44 Neuromuscular Blocking Agents Phase 4
45 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
46 Adjuvants, Anesthesia Phase 4
47 Analgesics Phase 4,Phase 2,Phase 3
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
49 Analgesics, Opioid Phase 4,Phase 3
50 Anesthetics Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 570)
id Name Status NCT ID Phase
1 CT Coronary Angiogram Versus Traditional Care in Emergency Department Assessment of Potential ACS Unknown status NCT00933400 Phase 4
2 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4
3 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
4 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
5 Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD Unknown status NCT02008786 Phase 4
6 Intensive Statin Therapy in PCI Patient With Acute Coronary Syndrome Unknown status NCT01372839 Phase 4
7 Assessment of Coronary Flow Reserve by Doppler Flow WIre in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Differences Between the Loading Dose of Prasugrel and Ticagrelor . Unknown status NCT02032303 Phase 4
8 Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel Unknown status NCT02032290 Phase 4
9 Impact of Ticagrelor on the Endothelial Healing Following Drug-eluting Stent Implantation in the Patients With Acute Coronary Syndrome Unknown status NCT02037412 Phase 4
10 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
11 Diagnosis and Treatment of ACS in the ED: The Impact of Rapid Bedside cTnI Testing on Outcomes Unknown status NCT00222352 Phase 4
12 Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Stable Angina, NSTEMI and STEMI Undergoing PCI Unknown status NCT02012140 Phase 4
13 Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain Completed NCT00718406 Phase 4
14 Usefulness of Chest Wall Tenderness as Bedside Test to Exclude Acute Coronary Syndrome in Different Demographic Groups Completed NCT01724996 Phase 4
15 AngioSeal Versus Radial Approach in Acute Coronary Syndrome Completed NCT01653587 Phase 4
16 Genotyping Infarct Patients to Adjust and Normalize Thienopyridine Treatment Completed NCT01134380 Phase 4
17 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4
18 Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients With Non ST Elevation Elevation Acute Coronary Syndrome Completed NCT01895751 Phase 4
19 Diagnosis and Treatment of Acute Coronary Syndrome in the ED & the Impact of Rapid Bedside cTnl on Outcome. Completed NCT00276432 Phase 4
20 Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty Completed NCT01121224 Phase 4
21 The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY) Completed NCT02683707 Phase 4
22 Abciximab, Clopidogrel and Percutaneous Coronary Intervention in Acute Coronary Syndrome (ISAR-REACT-2) Completed NCT00133003 Phase 4
23 Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents Completed NCT01502904 Phase 4
24 Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In-Stent Restenosis 4 Completed NCT01632371 Phase 4
25 DUrable Polymer-based STent CHallenge of Promus Element Versus ReSolute Integrity in an All Comers Population Completed NCT01331707 Phase 4
26 The Dual Antiplatelet Therapy Study (DAPT Study) Completed NCT00977938 Phase 4
27 Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/KOREAn Patients With Acute Coronary Syndromes Intended for Invasive Management Recruiting NCT02094963 Phase 4
28 Ticagrelor or Prasugrel Versus Clopidogrel in Elderly Patients With an Acute Coronary Syndrome and a High Bleeding Risk: Optimization of Antiplatelet Treatment in High-risk Elderly Recruiting NCT02317198 Phase 4
29 A Trial Comparing the Ischemic Preconditioning Effects of Ticagrelor and Clopidogrel in Humans Recruiting NCT01743937 Phase 4
30 Randomized "All-comer" Evaluation of a Permanent Polymer Resolute Integrity Stent Versus a Polymer Free Cre8 Stent Recruiting NCT02328898 Phase 4
31 Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers Recruiting NCT02618837 Phase 4
32 The Effect of IV Cangrelor and Oral Ticagrelor Study Recruiting NCT02733341 Phase 4
33 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4
34 Acarbose Cardiovascular Evaluation Trial Active, not recruiting NCT00829660 Phase 4
35 Sleep Intervention During Acute Lung Injury Active, not recruiting NCT01050699 Phase 4
36 Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration of Dual Antiplatelet Therapy. Design of the Short Duration of Dual antiplatElet Therapy With SyNergy II Stent in Patients Older Than 75 Years Undergoing Perc Active, not recruiting NCT02099617 Phase 4
37 Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT) Enrolling by invitation NCT01674803 Phase 4
38 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Not yet recruiting NCT03178643 Phase 4
39 OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS Not yet recruiting NCT02868203 Phase 4
40 Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP) Not yet recruiting NCT03068741 Phase 4
41 Evaluating Additional Platelet Inhibition in Patients With High Platelet Reactivity Undergoing Percutaneous Coronary Intervention Terminated NCT01339026 Phase 4
42 Comparison of Two Treatment Strategies in Patients With an Acute Coronary Syndrome Without ST Elevation Terminated NCT00445263 Phase 4
43 Allopurinol in Acute Coronary Syndrome Terminated NCT01457820 Phase 4
44 Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome Terminated NCT00435487 Phase 4
45 Routine Versus Selective Use of FFR to Guide PCI Terminated NCT02000661 Phase 4
46 Different Lipid Emulsions in Acute Lung Injury Patients Terminated NCT01814956 Phase 4
47 Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients Withdrawn NCT00337116 Phase 4
48 Coronary CT Angiography in Acute Chest Pain is a Cost Effective Risk Stratification Strategy Unknown status NCT00825435 Phase 3
49 The Usefulness of HyperQ Recordings for the Early Diagnosis of Acute Coronary Syndrome in Patients Presenting With Chest Pain Unknown status NCT00339105 Phase 3
50 Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome Unknown status NCT00473863 Phase 3

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

39
Lung, Bone, Neutrophil, Endothelial, Kidney, Bone Marrow, Thyroid

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 246)
id Title Authors Year
1
Plastic bronchitis: An unusual complication of acute chest syndrome in adult. ( 28443234 )
2017
2
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. ( 27574910 )
2016
3
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. ( 27353685 )
2016
4
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome. ( 27957377 )
2016
5
Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. ( 26936083 )
2016
6
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 27673392 )
2016
7
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients. ( 27412264 )
2016
8
Are We Missing the Mark? Fever, Respiratory Symptoms, Chest Radiographs and Acute Chest Syndrome in Sickle Cell Disease. ( 27153121 )
2016
9
Sickle cell crisis - Acute chest syndrome. ( 27728299 )
2016
10
Accuracy of Point-of-Care Lung Ultrasonography for Diagnosis of Acute Chest Syndrome in Pediatric Patients with Sickle Cell Disease and Fever. ( 27155438 )
2016
11
Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome. ( 27397962 )
2016
12
Rapidly progressive acute chest syndrome in individuals with sickle cell anemia. ( 27543812 )
2016
13
Acute Chest Syndrome, Asthma, and Lung Function in Sickle Cell Disease. Which Is the Chicken, and Which Is the Egg? ( 27509149 )
2016
14
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. ( 27011218 )
2016
15
Bedside Lung Ultrasound During Acute Chest Syndrome in Sickle Cell Disease. ( 26886600 )
2016
16
Inhaled nitric oxide for acute chest syndrome in adult sickle cell patients: a randomized controlled study. ( 26431718 )
2015
17
Age-dependent pathophysiology of acute chest syndrome in children with sickle cell disease. ( 25683565 )
2015
18
Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome. ( 25950690 )
2015
19
Acute chest syndrome following adenotonsillectomy in a pediatric patient with Hemoglobin SC disease. ( 25744494 )
2015
20
Platelets Decline during Vaso-Occlusive Crisis as a Predictor of Acute Chest Syndrome in Sickle Cell Disease. ( 26453077 )
2015
21
387: CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH ACUTE CHEST SYNDROME AT A CHILDREN'S HOSPITAL ICU. ( 26570048 )
2015
22
The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks. ( 26060589 )
2015
23
Antibiotics for treating acute chest syndrome in people with sickle cell disease. ( 25749695 )
2015
24
Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome. ( 26130498 )
2015
25
Casting a shadow. A 13-year-old girl with acute chest syndrome and respiratory failure. ( 26203611 )
2015
26
Guideline on the management of acute chest syndrome in sickle cell disease. ( 25824256 )
2015
27
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient. ( 26327979 )
2015
28
The Acute Chest Syndrome in Cameroonian children living with sickle cell disease. ( 26391669 )
2015
29
Pulmonary Platelet Thrombi and Vascular Pathology in Acute Chest Syndrome in Patients with Sickle Cell Disease. ( 26492581 )
2015
30
Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. ( 26033266 )
2015
31
Adjunctive therapy with inhaled nitric oxide for severe acute chest syndrome in patients with sickle cell disease. ( 26431719 )
2015
32
Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort. ( 25619382 )
2015
33
Radiographic patterns of acute chest syndrome. ( 25870181 )
2015
34
A case of acute chest syndrome complicated by diffuse cerebral infarcts in an adult with HbSI^-thalassemia(.). ( 26088144 )
2015
35
Outcomes of acute chest syndrome in adult patients with sickle cell disease: predictors of mortality. ( 24740290 )
2014
36
Associated factors of acute chest syndrome in children with sickle cell disease in French Guiana. ( 24678322 )
2014
37
Impact of VEGFA -583Ca88>a88T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease. ( 25130874 )
2014
38
Lung imaging during acute chest syndrome in sickle cell disease: computed tomography patterns and diagnostic accuracy of bedside chest radiograph. ( 23925645 )
2014
39
Sickle erythrocytes and platelets augment lung leukotriene synthesis with downregulation of anti-inflammatory proteins: relevance in the pathology of the acute chest syndrome. ( 25621162 )
2014
40
Acute chest syndrome in severity of sickle cell diseases. ( 25664108 )
2014
41
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 25086371 )
2014
42
Golden Tracheal Secretions and Bronchoalveolar Fluid During Acute Chest Syndrome in Sickle Cell Disease. ( 25316891 )
2014
43
Acute chest syndrome after laparoscopic splenectomy in children with sickle cell disease: operative time dependent? ( 25245325 )
2014
44
Plasma PTX3 levels in sickle cell disease patients, during vaso occlusion and acute chest syndrome (data from Saudi population). ( 23735470 )
2014
45
Prodromal illness before acute chest syndrome in pediatric patients with sickle cell disease. ( 24633302 )
2014
46
Ischemia-reperfusion injury in sickle cell anemia: relationship to acute chest syndrome, endothelial dysfunction, arterial vasculopathy, and inflammatory pain. ( 24589261 )
2014
47
Pulmonary function abnormalities and asthma are prevalent in children with sickle cell disease and are associated with acute chest syndrome. ( 23301782 )
2013
48
Relationship between acute chest syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study. ( 22460267 )
2013
49
Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients. ( 23719301 )
2013
50
Antibiotics for treating acute chest syndrome in people with sickle cell disease. ( 23440803 )
2013

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CXCL8 HBB IL1A NOS1 NOS3 PLA2G2A
2
Show member pathways
13.29 CXCL8 EDN1 IL1A NOS1 NOS3 PLA2G2A
3
Show member pathways
12.79 NOS1 NOS3 PLA2G10 PLA2G2A
4
Show member pathways
12.23 CXCL8 NOS1 NOS3
5 11.7 EDN1 IL1A NOS3 VCAM1
6 11.67 CXCL8 IL1A VCAM1
7
Show member pathways
11.34 CXCL8 IL1A VCAM1
8 11.34 CXCL8 IL1A NOS1 PLA2G2A
9
Show member pathways
11.32 PLA2G10 PLA2G2A
10 11.31 CXCL8 IL1A
11 11.26 NOS3 VCAM1
12
Show member pathways
11.23 PLA2G10 PLA2G2A
13 11.23 CXCL8 VCAM1
14
Show member pathways
11.2 NOS1 NOS3
15 11.19 CXCL8 HBB VCAM1
16
Show member pathways
11.17 NOS1 NOS3
17 11.09 HBB VCAM1
18 11.07 EDN1 NOS3
19 11.06 CXCL8 NOS3
20
Show member pathways
11.02 NOS1 NOS3
21 11.02 CXCL8 EDN1 IL1A NOS3 VCAM1
22 10.87 NOS1 NOS3
23 10.78 NOS1 NOS3 PLA2G2A
24 10.57 NOS1 NOS3
25 10.31 NOS1 NOS3

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CXCL8 EDN1 HBB IL1A PLA2G10 PLA2G2A
2 extracellular space GO:0005615 9.17 CXCL8 EDN1 HBB IL1A PLA2G10 PLA2G2A

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.77 EDN1 NOS1 VCAM1
2 cellular response to tumor necrosis factor GO:0071356 9.67 CXCL8 EDN1 VCAM1
3 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 EDN1 HBB
4 positive regulation of angiogenesis GO:0045766 9.65 CXCL8 IL1A NOS3
5 response to nicotine GO:0035094 9.64 EDN1 VCAM1
6 phosphatidic acid biosynthetic process GO:0006654 9.64 PLA2G10 PLA2G2A
7 negative regulation of blood pressure GO:0045776 9.63 NOS1 NOS3
8 positive regulation of neutrophil chemotaxis GO:0090023 9.63 CXCL8 EDN1
9 phosphatidylcholine acyl-chain remodeling GO:0036151 9.62 PLA2G10 PLA2G2A
10 positive regulation of mitotic nuclear division GO:0045840 9.62 EDN1 IL1A
11 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.61 PLA2G10 PLA2G2A
12 arachidonic acid secretion GO:0050482 9.61 PLA2G10 PLA2G2A
13 vasodilation GO:0042311 9.6 NOS1 NOS3
14 regulation of sodium ion transport GO:0002028 9.58 NOS1 NOS3
15 phosphatidylserine acyl-chain remodeling GO:0036150 9.58 PLA2G10 PLA2G2A
16 nitric oxide mediated signal transduction GO:0007263 9.57 NOS1 NOS3
17 phosphatidylglycerol acyl-chain remodeling GO:0036148 9.56 PLA2G10 PLA2G2A
18 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.55 PLA2G10 PLA2G2A
19 phosphatidylinositol acyl-chain remodeling GO:0036149 9.54 PLA2G10 PLA2G2A
20 nitric oxide biosynthetic process GO:0006809 9.52 NOS1 NOS3
21 negative regulation of calcium ion transport GO:0051926 9.51 NOS1 NOS3
22 positive regulation of guanylate cyclase activity GO:0031284 9.46 NOS1 NOS3
23 negative regulation of potassium ion transport GO:0043267 9.43 NOS1 NOS3
24 positive regulation of prostaglandin secretion GO:0032308 9.4 EDN1 PLA2G10
25 arginine catabolic process GO:0006527 9.37 NOS1 NOS3
26 regulation of blood pressure GO:0008217 9.33 EDN1 HBB NOS3
27 negative regulation of hydrolase activity GO:0051346 9.32 NOS1 NOS3
28 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.26 EDN1 NOS3
29 nitric oxide transport GO:0030185 8.96 EDN1 HBB
30 regulation of blood vessel size GO:0050880 8.8 EDN1 HBB NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 CXCL8 EDN1 IL1A
2 iron ion binding GO:0005506 9.61 HBB NOS1 NOS3
3 heme binding GO:0020037 9.54 HBB NOS1 NOS3
4 scaffold protein binding GO:0097110 9.51 NOS1 NOS3
5 NADP binding GO:0050661 9.49 NOS1 NOS3
6 phospholipase A2 activity GO:0004623 9.46 PLA2G10 PLA2G2A
7 FMN binding GO:0010181 9.4 NOS1 NOS3
8 arginine binding GO:0034618 9.32 NOS1 NOS3
9 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
10 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS1 NOS3
11 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS3
12 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Acute Chest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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