Aliases & Classifications for Acute Chest Syndrome

MalaCards integrated aliases for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 52 42 14 69
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 35 517.3
MeSH 42 D056586
SNOMED-CT 64 372146004
UMLS 69 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to asthma and sickle cell disease, and has symptoms including cheyne-stokes respiration, coughing and dyspnea. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Innate Immune System and Sweet Taste Signaling. The drugs Metoprolol and Morphine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are cardiovascular system and muscle

Wikipedia : 72 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 asthma 27.7 CXCL8 EDN1 HLA-DQB1 PLA2G2A VCAM1
2 sickle cell disease 10.6
3 ileocolitis 10.5 NOS1 NOS3
4 ophthalmia neonatorum 10.5 CXCL8 NOS3
5 47,xyy syndrome 10.4 NOS1 NOS3
6 progressive black carbon hyperpigmentation of infancy 10.3 EDN1 NOS3
7 indeterminate leprosy 10.3 EDN1 NOS3
8 lethal congenital contractural syndrome 2 10.3 EDN1 NOS3
9 dysphagia 10.2 CXCL8 VCAM1
10 aortopulmonary window 10.2 EDN1 NOS3
11 traumatic glaucoma 10.2 EDN1 NOS3
12 ovarian mucinous adenofibroma 10.2 CXCL8 VCAM1
13 sickle cell anemia 10.2
14 lymphadenitis 10.2 EDN1 NOS3
15 pasteurellosis 10.2 CXCL8 EDN1
16 capillary hemangioma 10.1 EDN1 NOS3
17 hepatic infarction 10.1 EDN1 HBB
18 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 EDN1 NOS3
19 focal dystonia 10.1 NOS3 VCAM1
20 osteogenesis imperfecta congenita, microcephaly, and cataracts 10.1 HLA-DQB1 NOS1
21 joint disorders 10.1 EDN1 NOS3
22 bernard-soulier syndrome, type a2 10.0 EDN1 NOS3
23 esophageal leukoplakia 10.0 EDN1 NOS3
24 spinal stenosis 10.0 CXCL8 NOS1 PLA2G2A
25 munchausen by proxy 10.0 EDN1 NOS1 NOS3
26 viral hepatitis 9.9 EDN1 NOS1 NOS3
27 pyelonephritis 9.9 CXCL8 EDN1 NOS3
28 diabetic encephalopathy 9.9 CXCL8 EDN1 NOS3
29 periampullary adenoma 9.9 CXCL8 EDN1 NOS3
30 spastic paraplegia 8 9.9 HBB VCAM1
31 preeclampsia/eclampsia 1 9.9 EDN1 NOS3 VCAM1
32 peripheral artery disease 9.8 EDN1 NOS3 VCAM1
33 renal fibrosis 9.8 EDN1 NOS3
34 pneumonia 9.8
35 bronchitis 9.8
36 endotheliitis 9.8
37 plastic bronchitis 9.8
38 autoimmune hepatitis 9.8 EDN1 NOS3 VCAM1
39 pericarditis 9.7 EDN1 NOS3 VCAM1
40 ischemia 9.7
41 cerebritis 9.7
42 thalassemia 9.7
43 thrombosis 9.7
44 diamond-blackfan anemia 3 9.7 CXCL8 EDN1 VCAM1
45 pulmonary hypertension 9.6
46 chlamydia 9.6
47 polymicrogyria, bilateral frontoparietal 9.6 EDN1 NOS3
48 acute necrotizing encephalitis 9.5
49 hemoglobin d disease 9.5
50 thyroiditis 9.5

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

UMLS symptoms related to Acute Chest Syndrome:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness

MGI Mouse Phenotypes related to Acute Chest Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 VCAM1 EDN1 HLA-DQB1 NOS1 NOS3 PLA2G10
2 muscle MP:0005369 9.02 EDN1 HLA-DQB1 NOS1 NOS3 PLA2G10

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
2
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
3
Amodiaquine Approved Phase 4 86-42-0 2165
4
Proguanil Approved Phase 4 500-92-5 4923
5
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
6
Sulfadoxine Approved Phase 4 2447-57-6 17134
7 Analgesics Phase 4,Phase 2,Phase 3
8 Analgesics, Opioid Phase 4,Phase 3
9 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
10 Narcotics Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Antimetabolites Phase 4,Phase 3,Phase 2
13 Adrenergic Agents Phase 4,Phase 1
14 Adrenergic Antagonists Phase 4
15 Adrenergic beta-1 Receptor Antagonists Phase 4
16 Adrenergic beta-Antagonists Phase 4
17 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
18 Antihypertensive Agents Phase 4
19 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Sympatholytics Phase 4
22 Anti-Infective Agents Phase 4,Phase 2,Phase 1
23 Anti-Bacterial Agents Phase 4,Phase 2
24 Antimalarials Phase 4
25 Antiparasitic Agents Phase 4
26 Antiprotozoal Agents Phase 4
27 Artemisinine Phase 4
28 Artemisinins Phase 4
29
Dihydroartemisinin Phase 4 71939-50-9 6918483
30 Folic Acid Antagonists Phase 4
31
Piperaquine Phase 4 4085-31-8 5079497
32 Renal Agents Phase 4
33
Nitric Oxide Approved Phase 2, Phase 3,Phase 1 10102-43-9 145068
34
Magnesium Sulfate Approved, Vet_approved Phase 2, Phase 3 7487-88-9 24083
35
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
36
Dalteparin Approved Phase 3,Phase 2 9005-49-6
37
Heparin Approved, Investigational Phase 3,Phase 2 9005-49-6 772 46507594
38
Simvastatin Approved Phase 3 79902-63-9 54454
39
Tirofiban Approved Phase 3 144494-65-5 60947
40
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
41
Nalbuphine Approved Phase 3 20594-83-6 5360630 5311304
42
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
43 Cisatracurium Experimental Phase 3 96946-41-7
44 Calcium, Dietary Phase 2, Phase 3
45 Anticholesteremic Agents Phase 3
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
47 Hypolipidemic Agents Phase 3
48 Lipid Regulating Agents Phase 3
49 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
50 Anti-Asthmatic Agents Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 141)

id Name Status NCT ID Phase Drugs
1 Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain Completed NCT00718406 Phase 4 Metoprolol;metoprolol plus morphine
2 Usefulness of Chest Wall Tenderness as Bedside Test to Exclude Acute Coronary Syndrome in Different Demographic Groups Completed NCT01724996 Phase 4
3 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Not yet recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
4 Coronary CT Angiography in Acute Chest Pain is a Cost Effective Risk Stratification Strategy Unknown status NCT00825435 Phase 3
5 The Usefulness of HyperQ Recordings for the Early Diagnosis of Acute Coronary Syndrome in Patients Presenting With Chest Pain Unknown status NCT00339105 Phase 3
6 Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome Unknown status NCT00473863 Phase 3
7 Trial for the Use of Pretest Probability to Reduce Unnecessary Testing for Low-Risk Patients With Chest Pain Unknown status NCT00243516 Phase 3
8 Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
9 Evaluation of Repeat Administration of Purified Poloxamer 188 Completed NCT02449616 Phase 3 MST-188
10 Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Completed NCT01737814 Phase 3 Saline;MST-188
11 Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Completed NCT01197417 Phase 2, Phase 3 Intravenous Magnesium Sulfate;Normal Saline Placebo
12 Aggrastat to Zocor (AtoZ) - the Use of Two Approved Drugs to Treat Patients Who Have Experienced Chest Pain or a Heart Attack (0733-180) Completed NCT00251576 Phase 3 A-Phase: tirofiban; Z-Phase simvastatin;Duration of Treatment: A-Phase: minimum suggested 48 hours, maximum suggested 108 hours. Z-Phase: 2 years;Comparator: A-Phase: low molecular weight heparin, unfractionated heparin;Duration of Treatment: A-Phase: low molecular weight heparin, 2 to 8 days; unfractionated heparin, minium suggested 48 hours, maximum 108 hours;Duration of Treatment: Z-Phase, 2 years.
13 Multicenter Study to Rule Out Myocardial Infarction by Cardiac Computed Tomography Completed NCT01084239 Phase 3
14 ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients Completed NCT01899560 Phase 3
15 Therapeutic Anticoagulation Strategy for Acute Chest Syndrome Recruiting NCT02580773 Phase 3 Prophylactic anticoagulation ( INNOHEP®);Curative anticoagulation ( INNOHEP®)
16 Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell Disease Recruiting NCT02433158 Phase 3 Rivipansel
17 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally Active, not recruiting NCT01380197 Phase 3 Morphine;Nubain
18 Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease Terminated NCT00530270 Phase 3 Dexamethasone;Placebo
19 A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) Terminated NCT01794000 Phase 3 Prasugrel;Placebo
20 IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome Completed NCT00434473 Phase 2 A-001
21 Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children Completed NCT01089439 Phase 2 Nitric oxide by inhalation INOMAX;Placebo
22 Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients Completed NCT00029731 Phase 2 Arginine hydrochloride
23 Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo Completed NCT01419977 Phase 2 Placebo;Dalteparin
24 Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia Completed NCT00001716 Phase 2 Nitric Oxide;Nitroglycerin
25 Treatment of Hemoglobin SC Disease Completed NCT02336373 Phase 2 hydroxyurea
26 Comprehensive Cardiothoracic Dual Source CT for the Early Triage of Patients With Acute Chest Pain Completed NCT01067456 Phase 2
27 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2 Nitric Oxide;Placebo
28 Study of 99mTc-glucarate to Detect Acute Coronary Syndrome in Chest Pain Patients. Completed NCT00614354 Phase 2 99mTc-glucarate solution
29 Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome Completed NCT00290602 Phase 2 Methylprednisolone sodium succinate
30 Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome Recruiting NCT02098993 Phase 2 Unfractionated heparin
31 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Recruiting NCT02776202 Phase 2 Fludarabine monophosphate
32 Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease Recruiting NCT02960503 Phase 1, Phase 2 Azithromycin
33 Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE) Recruiting NCT02640573 Phase 2 Hydroxyurea
34 A Phase II Trial of Regadenoson in Sickle Cell Anemia Recruiting NCT01788631 Phase 2 Regadenoson;Placebo
35 Arginine Therapy for Sickle Cell Disease Pain Recruiting NCT02536170 Phase 2 L-arginine;L-arginine Loading Dose
36 A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients Recruiting NCT02672540 Phase 2 SANGUINATE 320 mg/kg;Normal Saline
37 Vitamin D for Sickle-cell Respiratory Complications Active, not recruiting NCT01443728 Phase 2 Vitamin D3;Vitamin D3
38 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Adult Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Not yet recruiting NCT03264989 Phase 2 crizanlizumab
39 A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. Terminated NCT01522196 Phase 2 Varespladib
40 Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease Terminated NCT00532883 Phase 2 Hydroxyurea;Magnesium Pidolate
41 Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis Withdrawn NCT01925001 Phase 2 MP4CO;Sodium chloride solution
42 Citalopram for Sx/Util in Acute Coronary Syndrome Patients Withdrawn NCT01667744 Phase 1, Phase 2 Citalopram
43 Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial Completed NCT02187445 Phase 1 Budesonide inhalation suspension
44 Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease Completed NCT01895998 Phase 1 Albuterol
45 Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Completed NCT00023296 Phase 1 Nitric Oxide
46 A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease Recruiting NCT02630394 Phase 1 Azithromycin
47 A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome Recruiting NCT02697240 Phase 1 Intravenous citrulline
48 Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Recruiting NCT02989701 Phase 1 Plerixafor
49 Bi-Level Positive Airway Ventilation for Acute Chest Syndrome Unknown status NCT01589926
50 The Evaluation and Management of Patients With Acute Chest Pain in China Unknown status NCT02384863

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

39
Lung, Testes, Heart, Endothelial, Bone, Kidney, Bone Marrow

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 252)
id Title Authors Year
1
Association of Guideline-Adherent Antibiotic Treatment With Readmission of Children With Sickle Cell Disease Hospitalized With Acute Chest Syndrome. ( 28892533 )
2017
2
A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. ( 28905364 )
2017
3
Plastic bronchitis: An unusual complication of acute chest syndrome in adult. ( 28443234 )
2017
4
Association of plasma CD40L with acute chest syndrome in sickle cell anemia. ( 28609750 )
2017
5
Inflammatory and endothelial markers during vaso-occlusive crisis and acute chest syndrome in sickle cell disease. ( 28741692 )
2017
6
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. ( 28486752 )
2017
7
Extracorporeal Lung Support in Acute Chest Syndrome Associated With Sickle Cell Disease: A Rare Report of a Common Case. ( 28703372 )
2017
8
Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome. ( 27397962 )
2016
9
Acute Chest Syndrome, Asthma, and Lung Function in Sickle Cell Disease. Which Is the Chicken, and Which Is the Egg? ( 27509149 )
2016
10
Bedside Lung Ultrasound During Acute Chest Syndrome in Sickle Cell Disease. ( 26886600 )
2016
11
Are We Missing the Mark? Fever, Respiratory Symptoms, Chest Radiographs and Acute Chest Syndrome in Sickle Cell Disease. ( 27153121 )
2016
12
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. ( 27353685 )
2016
13
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome. ( 27957377 )
2016
14
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 27673392 )
2016
15
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients. ( 27412264 )
2016
16
Sickle cell crisis - Acute chest syndrome. ( 27728299 )
2016
17
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. ( 27011218 )
2016
18
Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. ( 26936083 )
2016
19
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. ( 27574910 )
2016
20
Accuracy of Point-of-Care Lung Ultrasonography for Diagnosis of Acute Chest Syndrome in Pediatric Patients with Sickle Cell Disease and Fever. ( 27155438 )
2016
21
Rapidly progressive acute chest syndrome in individuals with sickle cell anemia. ( 27543812 )
2016
22
A case of acute chest syndrome complicated by diffuse cerebral infarcts in an adult with HbSI^-thalassemia(.). ( 26088144 )
2015
23
Guideline on the management of acute chest syndrome in sickle cell disease. ( 25824256 )
2015
24
Casting a shadow. A 13-year-old girl with acute chest syndrome and respiratory failure. ( 26203611 )
2015
25
The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks. ( 26060589 )
2015
26
Antibiotics for treating acute chest syndrome in people with sickle cell disease. ( 25749695 )
2015
27
Radiographic patterns of acute chest syndrome. ( 25870181 )
2015
28
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient. ( 26327979 )
2015
29
Pulmonary Platelet Thrombi and Vascular Pathology in Acute Chest Syndrome in Patients with Sickle Cell Disease. ( 26492581 )
2015
30
Acute chest syndrome following adenotonsillectomy in a pediatric patient with Hemoglobin SC disease. ( 25744494 )
2015
31
Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort. ( 25619382 )
2015
32
Adjunctive therapy with inhaled nitric oxide for severe acute chest syndrome in patients with sickle cell disease. ( 26431719 )
2015
33
387: CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH ACUTE CHEST SYNDROME AT A CHILDREN'S HOSPITAL ICU. ( 26570048 )
2015
34
Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome. ( 26130498 )
2015
35
Platelets Decline during Vaso-Occlusive Crisis as a Predictor of Acute Chest Syndrome in Sickle Cell Disease. ( 26453077 )
2015
36
Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome. ( 25950690 )
2015
37
Inhaled nitric oxide for acute chest syndrome in adult sickle cell patients: a randomized controlled study. ( 26431718 )
2015
38
Age-dependent pathophysiology of acute chest syndrome in children with sickle cell disease. ( 25683565 )
2015
39
Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. ( 26033266 )
2015
40
The Acute Chest Syndrome in Cameroonian children living with sickle cell disease. ( 26391669 )
2015
41
Plasma PTX3 levels in sickle cell disease patients, during vaso occlusion and acute chest syndrome (data from Saudi population). ( 23735470 )
2014
42
Golden Tracheal Secretions and Bronchoalveolar Fluid During Acute Chest Syndrome in Sickle Cell Disease. ( 25316891 )
2014
43
Ischemia-reperfusion injury in sickle cell anemia: relationship to acute chest syndrome, endothelial dysfunction, arterial vasculopathy, and inflammatory pain. ( 24589261 )
2014
44
Associated factors of acute chest syndrome in children with sickle cell disease in French Guiana. ( 24678322 )
2014
45
Prodromal illness before acute chest syndrome in pediatric patients with sickle cell disease. ( 24633302 )
2014
46
Lung imaging during acute chest syndrome in sickle cell disease: computed tomography patterns and diagnostic accuracy of bedside chest radiograph. ( 23925645 )
2014
47
Outcomes of acute chest syndrome in adult patients with sickle cell disease: predictors of mortality. ( 24740290 )
2014
48
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 25086371 )
2014
49
Sickle erythrocytes and platelets augment lung leukotriene synthesis with downregulation of anti-inflammatory proteins: relevance in the pathology of the acute chest syndrome. ( 25621162 )
2014
50
Acute chest syndrome in severity of sickle cell diseases. ( 25664108 )
2014

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CXCL8 HBB HLA-DQB1 NOS1 NOS3 PLA2G2A
2
Show member pathways
12.76 NOS1 NOS3 PLA2G10 PLA2G2A
3
Show member pathways
12.21 CXCL8 NOS1 NOS3
4 11.72 EDN1 NOS3 VCAM1
5 11.62 CXCL8 NOS1 PLA2G2A
6
Show member pathways
11.3 PLA2G10 PLA2G2A
7 11.24 NOS3 VCAM1
8
Show member pathways
11.21 PLA2G10 PLA2G2A
9 11.2 CXCL8 VCAM1
10
Show member pathways
11.17 NOS1 NOS3
11
Show member pathways
11.14 NOS1 NOS3
12 11.05 HBB VCAM1
13 11.03 EDN1 NOS3
14 11.02 CXCL8 HBB VCAM1
15 11.01 CXCL8 NOS3
16
Show member pathways
10.96 NOS1 NOS3
17 10.92 CXCL8 EDN1 NOS3 VCAM1
18 10.81 NOS1 NOS3
19 10.58 NOS1 NOS3 PLA2G2A
20 10.44 NOS1 NOS3
21 10.16 NOS1 NOS3

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 EDN1 HBB PLA2G10 PLA2G2A VCAM1

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.76 EDN1 NOS1 VCAM1
2 cellular response to tumor necrosis factor GO:0071356 9.69 CXCL8 EDN1 VCAM1
3 response to heat GO:0009408 9.65 NOS1 NOS3
4 calcium-mediated signaling GO:0019722 9.64 CXCL8 EDN1
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.64 EDN1 HBB
6 response to nicotine GO:0035094 9.63 EDN1 VCAM1
7 phosphatidic acid biosynthetic process GO:0006654 9.63 PLA2G10 PLA2G2A
8 negative regulation of blood pressure GO:0045776 9.62 NOS1 NOS3
9 positive regulation of neutrophil chemotaxis GO:0090023 9.62 CXCL8 EDN1
10 phosphatidylcholine acyl-chain remodeling GO:0036151 9.61 PLA2G10 PLA2G2A
11 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.61 PLA2G10 PLA2G2A
12 arachidonic acid secretion GO:0050482 9.6 PLA2G10 PLA2G2A
13 vasodilation GO:0042311 9.59 NOS1 NOS3
14 phosphatidylserine acyl-chain remodeling GO:0036150 9.58 PLA2G10 PLA2G2A
15 regulation of sodium ion transport GO:0002028 9.57 NOS1 NOS3
16 nitric oxide mediated signal transduction GO:0007263 9.56 NOS1 NOS3
17 phosphatidylglycerol acyl-chain remodeling GO:0036148 9.55 PLA2G10 PLA2G2A
18 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.54 PLA2G10 PLA2G2A
19 phosphatidylinositol acyl-chain remodeling GO:0036149 9.52 PLA2G10 PLA2G2A
20 nitric oxide biosynthetic process GO:0006809 9.49 NOS1 NOS3
21 negative regulation of calcium ion transport GO:0051926 9.48 NOS1 NOS3
22 positive regulation of guanylate cyclase activity GO:0031284 9.46 NOS1 NOS3
23 negative regulation of potassium ion transport GO:0043267 9.43 NOS1 NOS3
24 regulation of blood pressure GO:0008217 9.43 EDN1 HBB NOS3
25 positive regulation of prostaglandin secretion GO:0032308 9.4 EDN1 PLA2G10
26 arginine catabolic process GO:0006527 9.37 NOS1 NOS3
27 negative regulation of hydrolase activity GO:0051346 9.32 NOS1 NOS3
28 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.16 EDN1 NOS3
29 nitric oxide transport GO:0030185 8.96 EDN1 HBB
30 regulation of blood vessel size GO:0050880 8.8 EDN1 HBB NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.61 HBB NOS1 NOS3
2 heme binding GO:0020037 9.58 HBB NOS1 NOS3
3 NADP binding GO:0050661 9.48 NOS1 NOS3
4 phospholipase A2 activity GO:0004623 9.46 PLA2G10 PLA2G2A
5 FMN binding GO:0010181 9.37 NOS1 NOS3
6 arginine binding GO:0034618 9.32 NOS1 NOS3
7 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
8 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS1 NOS3
9 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS3
10 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Acute Chest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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