MCID: ACT017
MIFTS: 56

Acute Chest Syndrome malady

Respiratory diseases category
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Summaries for Acute Chest Syndrome

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. the crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. the disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards: Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and sickle cell anemia, and has symptoms including diffuse infiltrates on chest radiograph, marked leukocytosis and hypoxemia. An important gene associated with Acute Chest Syndrome is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are NO dependent CFTR activation normal and CF and Effects of nitric oxide. The compounds ptio and adma have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are liver/biliary system and respiratory system.

Wikipedia:65 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Aliases & Classifications for Acute Chest Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

acute chest syndrome 8 10 45 62
acute chest syndrome in sickle cell disease 8


External Ids:

Disease Ontology8 DOID:1584
ICD9CM27 517.3
SNOMED-CT58 372146004
MeSH35 D056586

Related Diseases for Acute Chest Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease31.5THBS1, NOS3, HMOX1, PLA2G10, VCAM1, G6PD
2sickle cell anemia31.1HBB, G6PD
3asthma30.6EDN1, NOS1, PLA2G2A, IL8, VCAM1, HLA-DRB1
4ischemia30.2PLA2G2A, EDN1, NOS1, NOS3, HMOX1
5pneumonia10.3
6bronchitis10.3
7cerebritis10.2
8hypertension10.2
9thalassemia10.2
10thromboembolism10.2
11pulmonary function10.2
12rheumatoid vasculitis10.1VCAM1
13prinzmetal's variant angina10.1EDN1, NOS3
14coronary artery vasospasm10.1EDN1, NOS3
15histiocytosis-lymphadenopathy plus syndrome10.1HBB, G6PD
16low renin hypertension10.1EDN1
17portal hypertension10.1NOS3, EDN1
18diabetic retinopathy10.1VCAM1, THBS1, NOS3
19alpha thalassemia10.1G6PD, HBB
20meconium aspiration syndrome10.1PLA2G10, EDN1
21hemoglobinopathy10.1G6PD, HBB
22stroke, ischemic10.1NOS3, VCAM1, EDN1
23impotence10.1EDN1, NOS3, NOS1
24neonatal jaundice10.1G6PD, HMOX1
25rhinitis10.0VCAM1, PLA2G2A, IL8
26synovitis10.0VCAM1, IL8, PLA2G2A
27methemoglobinemia10.0G6PD
28septic shock10.0PLA2G2A, NOS3, IL8
29hemoglobin d disease10.0
30acute necrotizing encephalitis10.0
31addison's disease10.0
32beta thalassemia10.0
33aspiration pneumonia10.0
34encephalitis10.0
35influenza10.0
36hemoglobin ss10.0
37cor pulmonale10.0
38endotheliitis10.0
39sickle cell - hemoglobin d disease10.0
40coronary artery disease10.0PLA2G2A, EDN1, NOS3
41hypercholesterolemia10.0NOS3, PLA2G2A, VCAM1, EDN1
42hyperinsulinism10.0EDN1, NOS3, VCAM1
43hepatopulmonary syndrome10.0NOS3, EDN1, HMOX1
44primary hyperoxaluria10.0VCAM1, HMOX1, NOS3
45allergic asthma10.0VCAM1, IL8, NOS1
46insulin resistance10.0VCAM1, PLA2G2A, EDN1, NOS3
47multiple sclerosis 110.0HLA-DRB1, HLA-DQB1
48diabetic nephropathy10.0NOS3, THBS1, EDN1
49arteriosclerosis10.0NOS3, EDN1, VCAM1, HMOX1
50cerebral malaria10.0G6PD, THBS1, HMOX1, VCAM1

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to acute chest syndrome

Symptoms for Acute Chest Syndrome

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8Disease Ontology
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Symptoms:

8 (show all 7)
  • diffuse infiltrates on chest radiograph
  • marked leukocytosis
  • hypoxemia
  • tachypnea
  • pleuritic chest pain
  • fever
  • cough

Drugs & Therapeutics for Acute Chest Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Chest Syndrome

Search NIH Clinical Center for Acute Chest Syndrome

Genetic Tests for Acute Chest Syndrome

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Anatomical Context for Acute Chest Syndrome

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33MalaCards
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MalaCards organs/tissues related to Acute Chest Syndrome:

33
Lung, Bone, Bone marrow, Endothelial, Kidney

Animal Models for Acute Chest Syndrome or affiliated genes

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37MGI
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Publications for Acute Chest Syndrome

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52PubMed
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Articles related to Acute Chest Syndrome:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease. (24340416)
2013
2
Systemic Corticosteroids in Acute Chest Syndrome: Friend or Foe? (24268617)
2013
3
Pulmonary function abnormalities and asthma are prevalent in children with sickle cell disease and are associated with acute chest syndrome. (23301782)
2013
4
Mortality, asthma, smoking and acute chest syndrome in young adults with sickle cell disease. (23149803)
2013
5
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE). (22463614)
2012
6
Feasibility of early diagnosis and treatment of acute chest syndrome in sickle cell anaemia--a case report. (23304961)
2012
7
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. (22786487)
2012
8
Risk factors for acute chest syndrome in patients from low socioeconomic background: a cohort study from Sergipe, Brazil. (22034666)
2011
9
How I treat acute chest syndrome in children with sickle cell disease. (21406723)
2011
10
Improving care for children with sickle cell disease/acute chest syndrome. (21242225)
2011
11
Pulmonary artery thrombosis: another piece to the acute chest syndrome puzzle. (22045743)
2011
12
Acute chest syndrome in sickle cell disease due to the new influenza A (H1N1) virus infection. (20169545)
2010
13
The acute chest syndrome of sickle cell disease following aortic valve replacement. (19596703)
2009
14
Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adults. (19309475)
2009
15
Acute chest syndrome in pregnant women with hemoglobin SC disease. (19759888)
2009
16
Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. (18174543)
2008
17
A single-institution experience with treatment of severe acute chest syndrome: lack of rebound pain with dexamethasone plus transfusion therapy. (18391705)
2008
18
Acute chest syndrome during pregnancy as initial presentation of sickle cell disease: a case report. (18756432)
2008
19
Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study. (18815195)
2008
20
Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. (17849474)
2008
21
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms. (17351927)
2007
22
Antibiotics for treating acute chest syndrome in people with sickle cell disease. (17443613)
2007
23
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. (17262858)
2007
24
Sickle cell disease patients in eastern province of Saudi Arabia suffer less severe acute chest syndrome than patients with African haplotypes. (19727367)
2007
25
Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome. (16798640)
2006
26
Transfusion medicine illustrated. Marrow emboli in acute chest syndrome: artifact or etiology? (17002619)
2006
27
Acute chest syndrome in adult sickle cell disease in eastern Saudi Arabia. (15822496)
2005
28
Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease. (15663785)
2005
29
Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. (14687036)
2004
30
Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. (15288680)
2004
31
Induced sputum versus bronchoalveolar lavage during acute chest syndrome in sickle cell disease. (12969866)
2003
32
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. (12368703)
2002
33
Polymerized human Hb use in acute chest syndrome: a case report. (12421214)
2002
34
Acute chest syndrome in sickle cell disease in Saudi Arab Children in the Eastern Province. (17159388)
2002
35
Does splinting from thoracic bone ischemia and infarction contribute to the acute chest syndrome in sickle cell disease? (12114330)
2002
36
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome. (11751185)
2001
37
The role of rib infarcts in the acute chest syndrome of sickle cell diseases. (12673838)
2001
38
The acute chest syndrome of sickle cell disease. (10861328)
2000
39
Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. (11122088)
2000
40
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. (10861320)
2000
41
Acute chest syndrome in sickle cell disease. (11183563)
2000
42
Hemoglobin SC disease presenting as acute chest syndrome with ventilation-perfusion mismatches. (9973696)
1999
43
Endothelial cell nitric oxide production in acute chest syndrome. (10516198)
1999
44
Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. (10579281)
1999
45
Management of sickle cell disease. Acute chest syndrome is common in children before puberty. (9583909)
1998
46
Simultaneous occurrence of rib infarction and pulmonary infiltrates in sickle cell disease patients with acute chest syndrome. (8455078)
1993
47
Acute chest syndrome in sickle cell disease: CT evidence of microvascular occlusion. (8451435)
1993
48
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. (1578502)
1992
49
Evolution of acute chest syndrome in sickle cell trait: an ultrastructural and light microscopic study. (2617448)
1989
50
Acute chest syndrome in sickle cell disease. (3761099)
1986

Variations for Acute Chest Syndrome

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Expression for genes affiliated with Acute Chest Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for genes affiliated with Acute Chest Syndrome

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS1, NOS3
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis38
9.9NOS3, NOS1
3
Show member pathways
9.4NOS1, PLA2G10, NOS3, PLA2G2A
49.3EDN1, HMOX1, NOS3
59.2HLA-DRB1, HLA-DQB1, VCAM1
69.1PLA2G2A, NOS1, IL8
78.9HMOX1, NOS3, IL8
8
Show member pathways
8.9PLA2G10, HLA-DRB1, HLA-DQB1, PLA2G2A
98.8HLA-DQB1, NOS1, HLA-DRB1, THBS1
108.7IL8, VCAM1, HBB, THBS1
118.6IL8, HLA-DRB1, HLA-DQB1
12
Show member pathways
8.4IL8, PLA2G2A, NOS1, NOS3, EDN1
13
Show member pathways
8.1G6PD, PLA2G2A, HMOX1, NOS3, PLA2G10, NOS1

Compounds for genes affiliated with Acute Chest Syndrome

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Sources:
45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1ptio459.8NOS1, HMOX1, NOS3
2adma459.7NOS3, EDN1, NOS1
3apocynin45 6110.7EDN1, VCAM1, NOS1, NOS3
4isosorbide dinitrate45 51 1111.6EDN1, HMOX1, NOS3
5l-nmma459.6NOS3, NOS1, EDN1, VCAM1
6txb2459.6EDN1, THBS1, PLA2G10, PLA2G2A
7zinc protoporphyrin459.6NOS1, HMOX1, G6PD
8n(g)-nitro-l-arginine methyl ester459.5NOS1, NOS3, EDN1
9glycerol45 24 1111.4NOS1, NOS3, PLA2G10, G6PD, PLA2G2A
10alpha tocopherol459.3PLA2G2A, HMOX1, VCAM1, G6PD
11rosiglitazone29 45 51 24 1113.2VCAM1, HMOX1, NOS3, THBS1
12tamoxifen45 51 29 1112.1NOS1, NOS3, VCAM1, G6PD, HBB, THBS1
13ascorbic acid45 2410.0G6PD, NOS3, PLA2G2A, HMOX1, NOS1
14diphenyleneiodonium459.0NOS3, VCAM1, IL8, PLA2G2A, G6PD
1515-deoxy-delta-12,14-prostaglandin j2459.0NOS3, HMOX1, IL8, VCAM1
16atorvastatin45 51 29 24 1113.0HMOX1, VCAM1, THBS1, EDN1, PLA2G2A, NOS3
17prostacyclin458.9THBS1, VCAM1, NOS3, HMOX1, EDN1, PLA2G2A
18fmlp458.9PLA2G2A, PLA2G10, IL8, VCAM1, THBS1
19indomethacin45 29 61 1111.9HMOX1, NOS3, NOS1, PLA2G2A, EDN1
20nadph45 249.9HMOX1, G6PD, VCAM1, PLA2G2A, NOS1, NOS3
21sodium nitroprusside458.9NOS3, NOS1, G6PD, VCAM1, HMOX1, EDN1
22acetylcholine45 51 29 24 1112.9EDN1, PLA2G2A, HMOX1, NOS1, NOS3
23sp 60012545 619.8VCAM1, IL8, THBS1, HMOX1
24pdtc458.7NOS1, HMOX1, PLA2G2A, IL8, VCAM1
258-isoprostane458.7VCAM1, IL8, HMOX1, NOS3, EDN1
26rottlerin458.7VCAM1, EDN1, IL8, HMOX1, NOS3
27s-nitroso-n-acetylpenicillamine458.6EDN1, IL8, HMOX1, NOS1, NOS3
28n acetylcysteine458.5G6PD, HMOX1, PLA2G2A, IL8, VCAM1
29pd 98,059458.5THBS1, VCAM1, EDN1, IL8, NOS3
30ly294002458.5IL8, PLA2G2A, THBS1, HMOX1, NOS3, VCAM1
31doxorubicin45 51 1110.5NOS3, THBS1, G6PD, HMOX1, NOS1
32estrogen458.4G6PD, THBS1, HBB, VCAM1, HMOX1, NOS1
33genistein45 29 61 3 24 1113.3THBS1, EDN1, IL8, PLA2G2A, NOS1, NOS3
34histamine45 29 2410.3HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
35actinomycin d458.3PLA2G2A, HMOX1, NOS3, EDN1, G6PD, IL8
36lactate458.3HMOX1, HBB, G6PD, VCAM1, IL8, PLA2G2A
37cyclosporin a45 29 6110.2IL8, EDN1, THBS1, PLA2G2A, HMOX1, NOS1
38alanine458.2HLA-DRB1, THBS1, VCAM1, PLA2G2A, HMOX1, NOS1
39sb 20358045 619.1EDN1, THBS1, VCAM1, IL8, HMOX1, NOS3
40pge2458.0HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
41cysteine457.9VCAM1, THBS1, IL8, HBB, PLA2G2A, HMOX1
42dexamethasone45 51 29 1110.9VCAM1, IL8, PLA2G2A, HMOX1, NOS1, THBS1
43arginine457.9EDN1, HLA-DRB1, NOS3, NOS1, HBB, PLA2G2A
44superoxide45 248.9NOS1, VCAM1, IL8, PLA2G2A, HMOX1, NOS3
45cycloheximide457.9HMOX1, PLA2G2A, IL8, HBB, THBS1, EDN1
46serine457.9HBB, G6PD, PLA2G2A, NOS1, THBS1, VCAM1
47vegf457.8HMOX1, EDN1, THBS1, NOS3, VCAM1, PLA2G2A
48h2o2457.7HBB, NOS3, NOS1, HMOX1, G6PD, THBS1
49nitric oxide45 24 119.7NOS1, THBS1, HBB, IL8, HMOX1, VCAM1
50oxygen45 248.3VCAM1, THBS1, EDN1, NOS1, HMOX1, IL8

GO Terms for genes affiliated with Acute Chest Syndrome

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16Gene Ontology
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Cellular components related to Acute Chest Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DRB1, HLA-DQB1
2endocytic vesicle membraneGO:0306669.1HLA-DQB1, HLA-DRB1, NOS3
3extracellular spaceGO:0056157.9IL8, EDN1, THBS1, HMOX1, PLA2G2A, VCAM1
4extracellular regionGO:0055767.7PLA2G2A, EDN1, THBS1, HBB, IL8, PLA2G10

Biological processes related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrolase activityGO:05134610.3NOS3, NOS1
2arginine catabolic processGO:00652710.2NOS3, NOS1
3positive regulation of guanylate cyclase activityGO:03128410.2NOS3, NOS1
4chronic inflammatory responseGO:00254410.2VCAM1, THBS1
5regulation of systemic arterial blood pressure by endothelinGO:00310010.2NOS3, EDN1
6negative regulation of potassium ion transportGO:04326710.2NOS1, NOS3
7nitric oxide biosynthetic processGO:00680910.1NOS3, NOS1
8positive regulation of macrophage derived foam cell differentiationGO:01074410.1PLA2G10, PLA2G2A
9smooth muscle hyperplasiaGO:01480610.1HMOX1, NOS3
10regulation of blood vessel sizeGO:05088010.1NOS3, HBB
11nitric oxide transportGO:03018510.1HBB, EDN1
12phosphatidylinositol acyl-chain remodelingGO:03614910.1PLA2G10, PLA2G2A
13phosphatidylserine acyl-chain remodelingGO:0361509.9PLA2G10, PLA2G2A
14phosphatidylglycerol acyl-chain remodelingGO:0361489.8PLA2G10, PLA2G2A
15positive regulation of vasodilationGO:0459099.8HMOX1, NOS1, NOS3
16immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DQB1, HLA-DRB1
17humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DRB1, HLA-DQB1
18positive regulation of angiogenesisGO:0457669.7THBS1, HMOX1, NOS3
19regulation of blood pressureGO:0082179.7HBB, HMOX1, NOS3
20response to nicotineGO:0350949.7HMOX1, VCAM1, EDN1
21oxidation-reduction processGO:0551149.7VCAM1, G6PD, HBB
22nitric oxide mediated signal transductionGO:0072639.6NOS1, NOS3
23response to hypoxiaGO:0016669.6NOS1, VCAM1, THBS1, EDN1
24interferon-gamma-mediated signaling pathwayGO:0603339.5VCAM1, HLA-DRB1, HLA-DQB1
25positive regulation of neutrophil chemotaxisGO:0900239.3IL8, EDN1
26blood coagulationGO:0075969.3THBS1, HBB, NOS1, NOS3
27cellular response to tumor necrosis factorGO:0713569.1IL8, VCAM1, THBS1, EDN1
28small molecule metabolic processGO:0442818.7NOS3, HMOX1, PLA2G2A, PLA2G10, G6PD, HBB
29immune responseGO:0069558.5THBS1, HLA-DQB1, HLA-DRB1, IL8

Molecular functions related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.1NOS3, NOS1
2arginine bindingGO:03461810.0NOS1, NOS3
3tetrahydrobiopterin bindingGO:03461710.0NOS1, NOS3
4cadmium ion bindingGO:0468709.9NOS3, NOS1
5FMN bindingGO:0101819.9NOS3, NOS1
6NADPH-hemoprotein reductase activityGO:0039589.8NOS1, NOS3
7NADP bindingGO:0506619.8G6PD, NOS1, NOS3
8heme bindingGO:0200379.2NOS3, NOS1, HMOX1, HBB
9MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Acute Chest Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Chest Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet