MCID: ACT017
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Acute Chest Syndrome malady

Respiratory diseases category
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Summaries for Acute Chest Syndrome

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Disease Ontology:8 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. the crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. the disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary: Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and ischemia, and has symptoms including An important gene associated with Acute Chest Syndrome is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are NO dependent CFTR activation normal and CF and Effects of nitric oxide. The compounds ptio and adma have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are liver/biliary system and respiratory system.

Wikipedia:65 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Aliases & Classifications for Acute Chest Syndrome

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Acute Chest Syndrome, Aliases & Descriptions:

Name: Acute Chest Syndrome 8 10 44 62
 
Acute Chest Syndrome in Sickle Cell Disease 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:1584
MeSH34 D056586
SNOMED-CT57 372146004
ICD9CM27 517.3

Related Diseases for Acute Chest Syndrome

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Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.9EDN1, THBS1, HBB, G6PD, VCAM1, PLA2G10
2ischemia30.3NOS3, NOS1, HMOX1, PLA2G2A, EDN1
3asthma30.0EDN1, THBS1, HLA-DRB1, VCAM1, IL8, PLA2G2A
4sickle cell anemia10.7
5rheumatoid vasculitis10.5VCAM1
6prinzmetal's variant angina10.4NOS3, EDN1
7pneumonia10.4
8coronary artery vasospasm10.4NOS3, EDN1
9low renin hypertension10.3EDN1
10histiocytosis-lymphadenopathy plus syndrome10.3G6PD, HBB
11diabetic retinopathy10.3NOS3, VCAM1, THBS1
12portal hypertension10.3EDN1, NOS3
13bronchitis10.3
14alpha thalassemia10.3HBB, G6PD
15meconium aspiration syndrome10.3EDN1, PLA2G10
16hemoglobinopathy10.3HBB, G6PD
17stroke, ischemic10.2EDN1, VCAM1, NOS3
18impotence10.2NOS3, NOS1, EDN1
19neonatal jaundice10.2G6PD, HMOX1
20rhinitis10.2VCAM1, IL8, PLA2G2A
21hypertension10.2
22pulmonary hypertension10.2
23thalassemia10.2
24cerebritis10.2
25thromboembolism10.2
26pulmonary function10.2
27endotheliitis10.2
28synovitis10.2VCAM1, IL8, PLA2G2A
29methemoglobinemia10.2G6PD
30coronary artery anomaly10.2EDN1, PLA2G2A, NOS3
31septic shock10.2IL8, PLA2G2A, NOS3
32hyperinsulinism10.2NOS3, VCAM1, EDN1
33hypercholesterolemia10.2EDN1, VCAM1, PLA2G2A, NOS3
34hepatopulmonary syndrome10.2EDN1, HMOX1, NOS3
35primary hyperoxaluria10.2NOS3, HMOX1, VCAM1
36allergic asthma10.1NOS1, IL8, VCAM1
37insulin resistance10.1EDN1, VCAM1, PLA2G2A, NOS3
38multiple sclerosis 110.1HLA-DRB1, HLA-DQB1
39diabetic nephropathy10.1NOS3, THBS1, EDN1
40arteriosclerosis10.1NOS3, HMOX1, VCAM1, EDN1
41cerebral malaria10.1THBS1, G6PD, VCAM1, HMOX1
42acute necrotizing encephalitis10.1
43addison's disease10.1
44hemoglobin d disease10.1
45beta thalassemia10.1
46aspiration pneumonia10.1
47encephalitis10.1
48influenza10.1
49cor pulmonale10.1
50sickle cell - hemoglobin d disease10.1

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to acute chest syndrome

Symptoms for Acute Chest Syndrome

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Drugs & Therapeutics for Acute Chest Syndrome

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Drug clinical trials:

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Genetic Tests for Acute Chest Syndrome

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Anatomical Context for Acute Chest Syndrome

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MalaCards organs/tissues related to Acute Chest Syndrome:

32
Lung, Bone, Bone marrow, Endothelial, Neutrophil, Kidney

Animal Models for Acute Chest Syndrome or affiliated genes

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Publications for Acute Chest Syndrome

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Articles related to Acute Chest Syndrome:

(show top 50)    (show all 210)
idTitleAuthorsYear
1
Impact of VEGFA -583Ca88>a88T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease. (25130874)
2014
2
Outcomes of acute chest syndrome in adult patients with sickle cell disease: predictors of mortality. (24740290)
2014
3
Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease. (24340416)
2013
4
Systemic Corticosteroids in Acute Chest Syndrome: Friend or Foe? (24268617)
2013
5
Pulmonary function abnormalities and asthma are prevalent in children with sickle cell disease and are associated with acute chest syndrome. (23301782)
2013
6
Mortality, asthma, smoking and acute chest syndrome in young adults with sickle cell disease. (23149803)
2013
7
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE). (22463614)
2012
8
Feasibility of early diagnosis and treatment of acute chest syndrome in sickle cell anaemia--a case report. (23304961)
2012
9
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. (22786487)
2012
10
Risk factors for acute chest syndrome in patients from low socioeconomic background: a cohort study from Sergipe, Brazil. (22034666)
2011
11
How I treat acute chest syndrome in children with sickle cell disease. (21406723)
2011
12
Acute chest syndrome in sickle cell disease due to the new influenza A (H1N1) virus infection. (20169545)
2010
13
The acute chest syndrome of sickle cell disease following aortic valve replacement. (19596703)
2009
14
Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adults. (19309475)
2009
15
Acute chest syndrome in pregnant women with hemoglobin SC disease. (19759888)
2009
16
Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. (18174543)
2008
17
A single-institution experience with treatment of severe acute chest syndrome: lack of rebound pain with dexamethasone plus transfusion therapy. (18391705)
2008
18
Acute chest syndrome during pregnancy as initial presentation of sickle cell disease: a case report. (18756432)
2008
19
Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study. (18815195)
2008
20
Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. (17849474)
2008
21
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms. (17351927)
2007
22
Antibiotics for treating acute chest syndrome in people with sickle cell disease. (17443613)
2007
23
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. (17262858)
2007
24
Sickle cell disease patients in eastern province of Saudi Arabia suffer less severe acute chest syndrome than patients with African haplotypes. (19727367)
2007
25
Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome. (16798640)
2006
26
Transfusion medicine illustrated. Marrow emboli in acute chest syndrome: artifact or etiology? (17002619)
2006
27
Acute chest syndrome in adult sickle cell disease in eastern Saudi Arabia. (15822496)
2005
28
Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease. (15663785)
2005
29
Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. (14687036)
2004
30
Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. (15288680)
2004
31
Induced sputum versus bronchoalveolar lavage during acute chest syndrome in sickle cell disease. (12969866)
2003
32
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. (12368703)
2002
33
Polymerized human Hb use in acute chest syndrome: a case report. (12421214)
2002
34
Acute chest syndrome in sickle cell disease in Saudi Arab Children in the Eastern Province. (17159388)
2002
35
Does splinting from thoracic bone ischemia and infarction contribute to the acute chest syndrome in sickle cell disease? (12114330)
2002
36
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome. (11751185)
2001
37
The role of rib infarcts in the acute chest syndrome of sickle cell diseases. (12673838)
2001
38
The acute chest syndrome of sickle cell disease. (10861328)
2000
39
Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. (11122088)
2000
40
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. (10861320)
2000
41
Acute chest syndrome in sickle cell disease. (11183563)
2000
42
Hemoglobin SC disease presenting as acute chest syndrome with ventilation-perfusion mismatches. (9973696)
1999
43
Endothelial cell nitric oxide production in acute chest syndrome. (10516198)
1999
44
Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. (10579281)
1999
45
Management of sickle cell disease. Acute chest syndrome is common in children before puberty. (9583909)
1998
46
Simultaneous occurrence of rib infarction and pulmonary infiltrates in sickle cell disease patients with acute chest syndrome. (8455078)
1993
47
Acute chest syndrome in sickle cell disease: CT evidence of microvascular occlusion. (8451435)
1993
48
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. (1578502)
1992
49
Evolution of acute chest syndrome in sickle cell trait: an ultrastructural and light microscopic study. (2617448)
1989
50
Acute chest syndrome in sickle cell disease. (3761099)
1986

Variations for Acute Chest Syndrome

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Expression for genes affiliated with Acute Chest Syndrome

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Expression patterns in normal tissues for genes affiliated with Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for genes affiliated with Acute Chest Syndrome

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Pathways related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS3, NOS1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis37
9.9NOS1, NOS3
3
Show member pathways
9.4PLA2G10, PLA2G2A, NOS1, NOS3
49.3NOS3, HMOX1, EDN1
59.2VCAM1, HLA-DRB1, HLA-DQB1
69.1IL8, PLA2G2A, NOS1
78.9IL8, HMOX1, NOS3
8
Show member pathways
8.9PLA2G2A, PLA2G10, HLA-DRB1, HLA-DQB1
98.8NOS1, HLA-DRB1, HLA-DQB1, THBS1
108.7IL8, VCAM1, HBB, THBS1
118.6IL8, HLA-DRB1, HLA-DQB1
12
Show member pathways
8.4EDN1, IL8, PLA2G2A, NOS1, NOS3
13
Show member pathways
8.1HBB, G6PD, PLA2G10, PLA2G2A, HMOX1, NOS1

Compounds for genes affiliated with Acute Chest Syndrome

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Compounds related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1ptio449.8NOS1, HMOX1, NOS3
2adma449.7NOS3, EDN1, NOS1
3apocynin44 6110.7EDN1, VCAM1, NOS1, NOS3
4isosorbide dinitrate44 50 1111.6EDN1, HMOX1, NOS3
5l-nmma449.6NOS3, NOS1, EDN1, VCAM1
6txb2449.6EDN1, THBS1, PLA2G10, PLA2G2A
7zinc protoporphyrin449.6NOS1, HMOX1, G6PD
8n(g)-nitro-l-arginine methyl ester449.5NOS1, NOS3, EDN1
9glycerol44 24 1111.4NOS1, NOS3, PLA2G10, G6PD, PLA2G2A
10alpha tocopherol449.3PLA2G2A, HMOX1, VCAM1, G6PD
11rosiglitazone28 44 50 24 1113.2VCAM1, HMOX1, NOS3, THBS1
12tamoxifen44 50 28 1112.1NOS1, NOS3, VCAM1, G6PD, HBB, THBS1
13ascorbic acid44 2410.0G6PD, NOS3, PLA2G2A, HMOX1, NOS1
14diphenyleneiodonium449.0NOS3, VCAM1, IL8, PLA2G2A, G6PD
1515-deoxy-delta-12,14-prostaglandin j2449.0NOS3, HMOX1, IL8, VCAM1
16atorvastatin44 50 28 24 1113.0HMOX1, VCAM1, THBS1, EDN1, PLA2G2A, NOS3
17prostacyclin448.9THBS1, VCAM1, NOS3, HMOX1, EDN1, PLA2G2A
18fmlp448.9PLA2G2A, PLA2G10, IL8, VCAM1, THBS1
19indomethacin44 28 61 1111.9HMOX1, NOS3, NOS1, PLA2G2A, EDN1
20nadph44 249.9HMOX1, G6PD, VCAM1, PLA2G2A, NOS1, NOS3
21sodium nitroprusside448.9NOS3, NOS1, G6PD, VCAM1, HMOX1, EDN1
22acetylcholine44 50 28 24 1112.9EDN1, PLA2G2A, HMOX1, NOS1, NOS3
23sp 60012544 619.8VCAM1, IL8, THBS1, HMOX1
24pdtc448.7NOS1, HMOX1, PLA2G2A, IL8, VCAM1
258-isoprostane448.7VCAM1, IL8, HMOX1, NOS3, EDN1
26rottlerin448.7VCAM1, EDN1, IL8, HMOX1, NOS3
27s-nitroso-n-acetylpenicillamine448.6EDN1, IL8, HMOX1, NOS1, NOS3
28n acetylcysteine448.5G6PD, HMOX1, PLA2G2A, IL8, VCAM1
29pd 98,059448.5THBS1, VCAM1, EDN1, IL8, NOS3
30ly294002448.5IL8, PLA2G2A, THBS1, HMOX1, NOS3, VCAM1
31doxorubicin44 50 1110.5NOS3, THBS1, G6PD, HMOX1, NOS1
32estrogen448.4G6PD, THBS1, HBB, VCAM1, HMOX1, NOS1
33genistein44 28 61 2 24 1113.3THBS1, EDN1, IL8, PLA2G2A, NOS1, NOS3
34histamine44 28 2410.3HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
35actinomycin d448.3PLA2G2A, HMOX1, NOS3, EDN1, G6PD, IL8
36lactate448.3HMOX1, HBB, G6PD, VCAM1, IL8, PLA2G2A
37cyclosporin a44 28 6110.2IL8, EDN1, THBS1, PLA2G2A, HMOX1, NOS1
38alanine448.2HLA-DRB1, THBS1, VCAM1, PLA2G2A, HMOX1, NOS1
39sb 20358044 619.1EDN1, THBS1, VCAM1, IL8, HMOX1, NOS3
40pge2448.0HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
41cysteine447.9VCAM1, THBS1, IL8, HBB, PLA2G2A, HMOX1
42dexamethasone44 50 28 1110.9VCAM1, IL8, PLA2G2A, HMOX1, NOS1, THBS1
43arginine447.9EDN1, HLA-DRB1, NOS3, NOS1, HBB, PLA2G2A
44superoxide44 248.9NOS1, VCAM1, IL8, PLA2G2A, HMOX1, NOS3
45cycloheximide447.9HMOX1, PLA2G2A, IL8, HBB, THBS1, EDN1
46serine447.9HBB, G6PD, PLA2G2A, NOS1, THBS1, VCAM1
47vegf447.8HMOX1, EDN1, THBS1, NOS3, VCAM1, PLA2G2A
48h2o2447.7HBB, NOS3, NOS1, HMOX1, G6PD, THBS1
49nitric oxide44 24 119.7NOS1, THBS1, HBB, IL8, HMOX1, VCAM1
50oxygen44 248.3VCAM1, THBS1, EDN1, NOS1, HMOX1, IL8

GO Terms for genes affiliated with Acute Chest Syndrome

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Cellular components related to Acute Chest Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DRB1, HLA-DQB1
2endocytic vesicle membraneGO:0306669.1HLA-DQB1, HLA-DRB1, NOS3
3extracellular spaceGO:0056157.9HMOX1, PLA2G2A, IL8, VCAM1, THBS1, EDN1
4extracellular regionGO:0055767.7PLA2G2A, PLA2G10, IL8, HBB, THBS1, EDN1

Biological processes related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrolase activityGO:05134610.3NOS3, NOS1
2arginine catabolic processGO:00652710.2NOS3, NOS1
3positive regulation of guanylate cyclase activityGO:03128410.2NOS3, NOS1
4chronic inflammatory responseGO:00254410.2VCAM1, THBS1
5regulation of systemic arterial blood pressure by endothelinGO:00310010.2NOS3, EDN1
6negative regulation of potassium ion transportGO:04326710.2NOS1, NOS3
7nitric oxide biosynthetic processGO:00680910.1NOS3, NOS1
8positive regulation of macrophage derived foam cell differentiationGO:01074410.1PLA2G10, PLA2G2A
9smooth muscle hyperplasiaGO:01480610.1HMOX1, NOS3
10regulation of blood vessel sizeGO:05088010.1NOS3, HBB
11nitric oxide transportGO:03018510.1HBB, EDN1
12phosphatidylinositol acyl-chain remodelingGO:03614910.1PLA2G10, PLA2G2A
13phosphatidylserine acyl-chain remodelingGO:0361509.9PLA2G10, PLA2G2A
14phosphatidylglycerol acyl-chain remodelingGO:0361489.8PLA2G10, PLA2G2A
15positive regulation of vasodilationGO:0459099.8HMOX1, NOS1, NOS3
16immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DQB1, HLA-DRB1
17humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DRB1, HLA-DQB1
18positive regulation of angiogenesisGO:0457669.7THBS1, HMOX1, NOS3
19regulation of blood pressureGO:0082179.7HBB, HMOX1, NOS3
20response to nicotineGO:0350949.7HMOX1, VCAM1, EDN1
21oxidation-reduction processGO:0551149.7VCAM1, G6PD, HBB
22nitric oxide mediated signal transductionGO:0072639.6NOS1, NOS3
23response to hypoxiaGO:0016669.6NOS1, VCAM1, THBS1, EDN1
24interferon-gamma-mediated signaling pathwayGO:0603339.5VCAM1, HLA-DRB1, HLA-DQB1
25positive regulation of neutrophil chemotaxisGO:0900239.3IL8, EDN1
26blood coagulationGO:0075969.3THBS1, HBB, NOS1, NOS3
27cellular response to tumor necrosis factorGO:0713569.1IL8, VCAM1, THBS1, EDN1
28small molecule metabolic processGO:0442818.7NOS3, HMOX1, PLA2G2A, PLA2G10, G6PD, HBB
29immune responseGO:0069558.5THBS1, HLA-DQB1, HLA-DRB1, IL8

Molecular functions related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.1NOS3, NOS1
2arginine bindingGO:03461810.0NOS1, NOS3
3tetrahydrobiopterin bindingGO:03461710.0NOS1, NOS3
4cadmium ion bindingGO:0468709.9NOS3, NOS1
5FMN bindingGO:0101819.9NOS3, NOS1
6NADPH-hemoprotein reductase activityGO:0039589.8NOS1, NOS3
7NADP bindingGO:0506619.8G6PD, NOS1, NOS3
8heme bindingGO:0200379.2NOS3, NOS1, HMOX1, HBB
9MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Acute Chest Syndrome

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Sources for Acute Chest Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet