MCID: ACT017
MIFTS: 53

Acute Chest Syndrome malady

Summaries for Acute Chest Syndrome

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. the crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. the disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards: Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and asthma, and has symptoms including fever, pleuritic chest pain and tachypnea. An important gene associated with Acute Chest Syndrome is PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)), and among its related pathways are glutamine degradation I and NO-dependent CFTR activation (normal and CF). The compounds pge2 and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and lung, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Aliases & Classifications for Acute Chest Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

acute chest syndrome 8 10 45 61
acute chest syndrome in sickle cell disease 8


External Ids:

Disease Ontology8 DOID:1584
MeSH35 D056586
SNOMED-CT57 372146004
ICD9CM27 517.3

Related Diseases for Acute Chest Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease31.6VCAM1, NOS3, THBS1, HMOX1, PLA2G10, EDN1
2asthma30.7EDN1, PLA2G2A, THBS1, NOS1, VCAM1
3thalassemia30.2G6PD
4thromboembolism30.2NOS3, G6PD
5vascular disease30.0G6PD, EDN1, GP1BA, HMOX1, NOS3, VCAM1
6n syndrome10.7
7sickle cell anemia10.6
8adult syndrome10.6
9hemoglobin d disease10.4
10hemoglobin c disease10.4
11bronchitis10.3
12young syndrome10.3
13micro syndrome10.2
14pulmonary function10.2
15lipid pneumonia10.0
16beta thalassemia10.0
17acute necrotizing encephalitis10.0
18addison's disease10.0
19aortic disease10.0
20aspiration pneumonia10.0
21short syndrome10.0
22kid syndrome10.0
23chronic pain10.0
24aortic valve disease10.0
25sickle cell - hemoglobin d disease10.0
26sickle cell - hemoglobin c disease10.0
27antiphospholipid syndrome10.0VCAM1
28glomerulonephritis10.0VCAM1
29splenic sequestration10.0GBA2
30allergic rhinitis10.0VCAM1
31malaria10.0G6PD
32hepatitis10.0CFB
33hypertriglyceridemia10.0VCAM1
34myositis10.0VCAM1
35uremia10.0NOS3, VCAM1
36hyperglycemia10.0VCAM1, NOS3
37hyperhomocysteinemia10.0VCAM1, NOS3
38rhinitis10.0VCAM1, PLA2G2A
39autoimmune hemolytic anemia10.0G6PD
40spinal cord ischemia10.0PLA2G2A
41glioblastoma multiforme10.0THBS1
42pancreatitis10.0PLA2G1B, PLA2G2A
43prion disease10.0HMOX1
44vitiligo10.0G6PD
45nephritis10.0VCAM1, CFB
46lupus nephritis10.0CFB, VCAM1
47sarcoidosis10.0HLA-DQB1
48essential hypertension10.0EDN1, NOS3
49prinzmetal's variant angina10.0NOS3, EDN1
50dementia10.0NOS1

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to acute chest syndrome

Clinical Features for Acute Chest Syndrome

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • fever
  • pleuritic chest pain
  • tachypnea
  • cough
  • hypoxemia
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

Drugs & Therapeutics for Acute Chest Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Chest Syndrome

Drug clinical trials:

Search ClinicalTrials for Acute Chest Syndrome

Search NIH Clinical Center for Acute Chest Syndrome

Search CenterWatch for Acute Chest Syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Chest Syndrome:

33
Bone marrow, Kidney, Lung, T cells, B cells, Endothelial

Animal Models for Acute Chest Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Chest Syndrome

Sources:
51PubMed
See all sources

Articles related to Acute Chest Syndrome:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
Plasma PTX3 levels in sickle cell disease patients, during vaso occlusion and acute chest syndrome (data from Saudi population). (23735470)
2014
2
Lung imaging during acute chest syndrome in sickle cell disease: computed tomography patterns and diagnostic accuracy of bedside chest radiograph. (23925645)
2014
3
Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease. (24340416)
2013
4
A case of catastrophic antiphospholipid syndrome, which presented an acute interstitial pneumonia-like image on chest CT scan. (23553659)
2013
5
Painful vaso-occlusive crisis as a prodromal phase of acute chest syndrome. Is only one chest X-ray enough? A case report. (24093819)
2013
6
Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients. (23719301)
2013
7
Comparison of chest computed tomography features in the acute phase of cardiogenic pulmonary edema and acute respiratory distress syndrome on arrival at the emergency department. (23615573)
2013
8
Comparison of automated red cell exchange transfusion and simple transfusion for the treatment of children with sickle cell disease acute chest syndrome. (24000077)
2013
9
Antibiotics for treating acute chest syndrome in people with sickle cell disease. (23440803)
2013
10
Feasibility of early diagnosis and treatment of acute chest syndrome in sickle cell anaemia--a case report. (23304961)
2012
11
Improving care for children with sickle cell disease/acute chest syndrome. (21242225)
2011
12
Pulmonary artery thrombosis: another piece to the acute chest syndrome puzzle. (22045743)
2011
13
Risk factors for acute chest syndrome in patients from low socioeconomic background: a cohort study from Sergipe, Brazil. (21792037)
2011
14
Acute chest syndrome is associated with history of asthma in hemoglobin SC disease. (21671365)
2011
15
Acute chest syndrome in sickle cell disease due to the new influenza A (H1N1) virus infection. (20169545)
2010
16
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. (20091653)
2010
17
The acute chest syndrome of sickle cell disease following aortic valve replacement. (19596703)
2009
18
Acute chest syndrome in pregnant women with hemoglobin SC disease. (19759888)
2009
19
What you need to know about acute chest syndrome. (19474609)
2009
20
Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study. (18815195)
2008
21
Acute chest syndrome after splenectomy in children with sickle cell disease. (18485954)
2008
22
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms. (17351927)
2007
23
Calcified pulmonary thromboembolism in a child with sickle cell disease: value of multidetector CT in patients with acute chest syndrome. (16708206)
2006
24
Addison's disease presenting as acute chest syndrome: case report and review of literature. (17111738)
2006
25
Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia. (16690969)
2006
26
Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome. (15802550)
2005
27
Opioid selection during sickle cell pain crisis and its impact on the development of acute chest syndrome. (15926170)
2005
28
Asthma in the pediatric sickle cell patient with acute chest syndrome. (15867831)
2005
29
Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome. (15182051)
2004
30
Clinical presentation of acute chest syndrome in sickle cell disease. (15192168)
2004
31
The use of bilevel positive airway pressure for the treatment of acute chest syndrome of sickle cell disease. (15212227)
2004
32
Treatment of plastic bronchitis in acute chest syndrome of sickle cell disease with intratracheal rhDNase. (12818912)
2003
33
Acute chest syndrome in sickle cell disease in Saudi Arab Children in the Eastern Province. (17159388)
2002
34
Acute chest syndrome. (12370708)
2002
35
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome. (11751185)
2001
36
Acute chest syndrome after abdominal surgery in children with sickle cell disease: Is a laparoscopic approach better? (11329573)
2001
37
Increased F2 isoprostanes in the acute chest syndrome of sickle cell disease as a marker of oxidative stress. (11673218)
2001
38
Acute chest syndrome of sickle cell disease: new light on an old problem. (11224686)
2001
39
The acute chest syndrome of sickle cell disease. (10861328)
2000
40
The acute chest syndrome of sickle cell disease. (10518074)
1999
41
Clinician assessment for acute chest syndrome in febrile patients with sickle cell disease: is it accurate enough? (10381996)
1999
42
Plastic bronchitis: an unusual complication associated with sickle cell disease and the acute chest syndrome. (9200374)
1997
43
The role of cardiac troponin T and other new biochemical markers in evaluation and risk stratification of patients with acute chest pain syndromes. (9383587)
1997
44
Phospholipase A2 levels in acute chest syndrome of sickle cell disease. (8630425)
1996
45
Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism. (8630622)
1996
46
Peak expiratory flow rate and the acute chest syndrome in homozygous sickle cell disease. (2025011)
1991
47
Rib infarcts and acute chest syndrome in sickle cell diseases. (1672922)
1991
48
Acute chest syndrome in sickle cell disease. (3761099)
1986
49
Acute chest syndrome in sickle cell disease: etiology and clinical correlates. (4067742)
1985
50
"Acute chest syndrome" in adults with sickle cell anemia. Microbiology, treatment, and prevention. (32855)
1979

Genetic Variations for Acute Chest Syndrome

Expression for genes affiliated with Acute Chest Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for genes affiliated with Acute Chest Syndrome

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0NOS3, NOS1
2
NO-dependent CFTR activation (normal and CF)
10.0NOS3, NOS1
39.8HMOX1, EDN1, NOS3
4
Hide members
9.8PLA2G2A, PLA2G1B, PLA2G10
5
Hide members
9.8PLA2G10, PLA2G1B, PLA2G2A
6
Anandamide biosynthesis and metabolism
Hide members
9.8PLA2G1B, PLA2G2A, PLA2G10
79.8PLA2G2A, PLA2G10, PLA2G1B
8
Hide members
9.8PLA2G1B, PLA2G10, PLA2G2A
9
Hide members
9.7PLA2G2A, PLA2G10, PLA2G1B, NOS3
10
Hide members
9.6GP1BA, NOS1, NOS3, THBS1
11
Hide members
9.6PLA2G1B, PLA2G2A, PLA2G10, HLA-DQB1
129.5PLA2G1B, PLA2G2A, PLA2G10, SLC12A2
13
Hide members
9.4SLC12A2, NOS1, HMOX1, NOS3
14
Hide members
9.4PLA2G10, PLA2G2A, PLA2G1B, NOS3, NOS1
15
Hide members
8.9NOS1, GBA2, PLA2G10, PLA2G2A, PLA2G1B, HMOX1

Compounds for genes affiliated with Acute Chest Syndrome

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1pge24510.7PLA2G10
2alpha tocopherol4510.4PLA2G2A, G6PD
3N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine1110.3NOS3, NOS1
4sn mesoporphyrin4510.3G6PD, HMOX1
5N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine1110.3NOS3, NOS1
6Nitroarginine1110.3NOS1, NOS3
7N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE1110.3NOS3, NOS1
8isosorbide dinitrate45 50 1112.2NOS3, HMOX1, EDN1
9L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide1110.2NOS3, NOS1
10S-Ethyl-N-Phenyl-Isothiourea1110.2NOS3, NOS1
11diphenyleneiodonium4510.2VCAM1, PLA2G2A, NOS3, G6PD
12ptio4510.2NOS1, HMOX1, NOS3
13L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide1110.2NOS3, NOS1
14adma4510.2NOS1, EDN1, NOS3
15n(g)-nitro-l-arginine methyl ester4510.1NOS3, EDN1, NOS1
16ng-nitro-l-arginine4510.1EDN1, NOS3, NOS1
17zinc protoporphyrin4510.1G6PD, HMOX1, NOS1
188-isoprostane4510.1EDN1, HMOX1, VCAM1, NOS3
19apocynin45 6011.1VCAM1, NOS3, NOS1, EDN1
20rottlerin4510.1EDN1, VCAM1, NOS3, HMOX1
21l-nmma4510.0NOS1, EDN1, VCAM1, NOS3
22s-nitroso-n-acetylpenicillamine4510.0NOS1, NOS3, EDN1, HMOX1
23pdtc4510.0VCAM1, NOS1, HMOX1, PLA2G2A
24l-arginine29 11 2412.0ART4, NOS1, NOS3
25nadph45 2410.9PLA2G1B, NOS1, PLA2G2A, G6PD
26alpha-linolenic acid45 11 2411.9PLA2G10, PLA2G2A, PLA2G1B
27phosphatidylserine45 29 1111.9THBS1, PLA2G2A, PLA2G10, GP1BA, G6PD
28fmlp459.8PLA2G10, PLA2G2A, PLA2G1B, THBS1, VCAM1
29txb2459.8PLA2G1B, EDN1, PLA2G10, PLA2G2A, THBS1
30phosphatidylcholine459.8G6PD, PLA2G10, PLA2G2A, PLA2G1B, VCAM1
31aspirin45 50 29 2412.8PLA2G2A, G6PD, GP1BA, NOS3, HMOX1
32atorvastatin45 50 29 11 2413.8EDN1, PLA2G2A, HMOX1, THBS1, NOS3, VCAM1
33tamoxifen45 50 29 1112.7VCAM1, NOS3, THBS1, G6PD, NOS1
34ascorbic acid45 2410.7PLA2G2A, G6PD, NOS3, HMOX1, NOS1
35rosiglitazone45 50 29 11 2413.7HMOX1, THBS1, NOS3, VCAM1
36ketamine45 29 1111.7HMOX1, NOS3, NOS1
37genistein45 29 60 2 11 2414.7VCAM1, NOS3, EDN1, NOS1, PLA2G2A, THBS1
38sodium nitroprusside459.6VCAM1, HMOX1, NOS1, EDN1, G6PD, NOS3
39glycerol45 11 2411.6PLA2G10, PLA2G2A, PLA2G1B, NOS3, NOS1, G6PD
40sb 20358045 6010.6EDN1, THBS1, NOS3, NOS1, VCAM1, HMOX1
41prostacyclin459.5EDN1, PLA2G2A, GP1BA, VCAM1, NOS3, THBS1
42lactate459.5PLA2G1B, G6PD, GP1BA, PLA2G2A, HMOX1, VCAM1
43acetylcholine45 50 29 11 2413.4EDN1, PLA2G2A, NOS3, HMOX1, NOS1
44oxygen45 2410.4CYGB, HMOX1, SLC12A2, NOS1, PLA2G1B
45vegf459.4PLA2G2A, NOS1, NOS3, HMOX1, VCAM1, EDN1
46indomethacin45 60 29 1112.3NOS3, EDN1, GP1BA, NOS1, HMOX1, PLA2G2A
47superoxide45 2410.2G6PD, PLA2G1B, HMOX1, PLA2G2A, NOS3, NOS1
48histamine45 29 2411.1EDN1, VCAM1, HMOX1, PLA2G2A, NOS1
49h2o2459.0CYGB, NOS1, THBS1, HMOX1, PLA2G1B, PLA2G2A
50nitric oxide45 11 2410.9CYGB, HMOX1, EDN1, THBS1, NOS3, VCAM1

GO Terms for genes affiliated with Acute Chest Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Chest Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5THBS1, PLA2G1B, PLA2G2A
2extracellular spaceGO:0056159.1VCAM1, THBS1, HMOX1, PLA2G1B, PLA2G2A, EDN1

Biological processes related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle hyperplasiaGO:01480610.4HMOX1, NOS3
2regulation of systemic arterial blood pressure by endothelinGO:00310010.3EDN1, NOS3
3positive regulation of guanylate cyclase activityGO:03128410.3NOS3, NOS1
4chronic inflammatory responseGO:00254410.3VCAM1, THBS1
5negative regulation of hydrolase activityGO:05134610.3NOS1, NOS3
6arginine catabolic processGO:00652710.3NOS1, NOS3
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.2NOS3, HMOX1
8phosphatidylinositol acyl-chain remodelingGO:03614910.2PLA2G10, PLA2G2A, PLA2G1B
9phosphatidylserine acyl-chain remodelingGO:03615010.2PLA2G2A, PLA2G10, PLA2G1B
10phosphatidylglycerol acyl-chain remodelingGO:03614810.2PLA2G1B, PLA2G2A, PLA2G10
11phosphatidylethanolamine acyl-chain remodelingGO:03615210.2PLA2G1B, PLA2G10, PLA2G2A
12positive regulation of macrophage derived foam cell differentiationGO:01074410.1PLA2G10, PLA2G2A
13phosphatidylcholine acyl-chain remodelingGO:03615110.1PLA2G10, PLA2G1B, PLA2G2A
14phosphatidic acid biosynthetic processGO:00665410.1PLA2G2A, PLA2G1B, PLA2G10
15positive regulation of vasodilationGO:04590910.1NOS3, NOS1, HMOX1
16negative regulation of potassium ion transportGO:04326710.1NOS3, NOS1
17positive regulation of angiogenesisGO:04576610.0HMOX1, THBS1, NOS3
18nitric oxide biosynthetic processGO:0068099.9NOS3, NOS1
19response to hypoxiaGO:0016669.9VCAM1, NOS1, THBS1, EDN1
20glycerophospholipid biosynthetic processGO:0464749.8PLA2G2A, PLA2G1B, PLA2G10
21intracellular protein kinase cascadeGO:0072439.4HMOX1, EDN1, PLA2G1B
22small molecule metabolic processGO:0442819.2G6PD, PLA2G10, PLA2G2A, PLA2G1B, HMOX1, NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.2NOS3, NOS1
2tetrahydrobiopterin bindingGO:03461710.1NOS1, NOS3
3arginine bindingGO:03461810.1NOS1, NOS3
4phospholipase A2 activityGO:00462310.0PLA2G2A, PLA2G10, PLA2G1B
5NADPH-hemoprotein reductase activityGO:00395810.0NOS1, NOS3
6FMN bindingGO:01018110.0NOS1, NOS3
7NADP bindingGO:05066110.0G6PD, NOS1, NOS3
8calcium-dependent phospholipase A2 activityGO:0474989.9PLA2G2A, PLA2G1B
9cadmium ion bindingGO:0468709.7NOS3, NOS1
10heme bindingGO:0200379.7NOS3, HMOX1, CYGB, NOS1

Products for genes affiliated with Acute Chest Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Chest Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet