MCID: ACT017
MIFTS: 48

Acute Chest Syndrome malady

Summaries for Acute Chest Syndrome

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Disease Ontology:9 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. the crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. the disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary: Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell anemia and sickle cell disease, and has symptoms including fever, pleuritic chest pain and tachypnea. An important gene associated with Acute Chest Syndrome is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are NO dependent CFTR activation normal and CF and Effects of nitric oxide. The compounds ptio and adma have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are liver/biliary system and respiratory system.

Wikipedia:63 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in... more...

Aliases & Classifications for Acute Chest Syndrome

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Acute Chest Syndrome, Aliases & Descriptions:

Name: Acute Chest Syndrome 9 11 43 60
 
Acute Chest Syndrome in Sickle Cell Disease 9


External Ids:

Disease Ontology9 DOID:1584
ICD9CM27 517.3
SNOMED-CT55 372146004
MeSH33 D056586

Related Diseases for Acute Chest Syndrome

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Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell anemia31.5HBB, G6PD
2sickle cell disease30.9EDN1, THBS1, HBB, G6PD, VCAM1, PLA2G10
3ischemia30.3NOS3, NOS1, HMOX1, PLA2G2A, EDN1
4asthma30.0EDN1, THBS1, HLA-DRB1, VCAM1, IL8, PLA2G2A
5rheumatoid vasculitis10.5VCAM1
6prinzmetal's variant angina10.4NOS3, EDN1
7pneumonia10.4
8coronary artery vasospasm10.3NOS3, EDN1
9hereditary spherocytosis10.3G6PD, HBB
10microvascular complications of diabetes 510.3NOS3, VCAM1, THBS1
11bronchitis10.3
12portal hypertension10.3EDN1, NOS3
13thalassemias, alpha-10.3HBB, G6PD
14meconium aspiration syndrome10.3EDN1, PLA2G10
15hemoglobinopathy10.3HBB, G6PD
16stroke, ischemic10.2EDN1, VCAM1, NOS3
17impotence10.2NOS3, NOS1, EDN1
18neonatal jaundice10.2G6PD, HMOX1
19pulmonary function10.2
20pulmonary hypertension10.2
21thalassemia10.2
22cerebritis10.2
23endotheliitis10.2
24rhinitis10.2VCAM1, IL8, PLA2G2A
25synovitis10.2VCAM1, IL8, PLA2G2A
26methemoglobinemia10.2G6PD
27coronary artery disease10.2EDN1, PLA2G2A, NOS3
28hypercholesterolemia, familial10.2EDN1, VCAM1, PLA2G2A, NOS3
29hyperinsulinism10.2NOS3, VCAM1, EDN1
30hepatopulmonary syndrome10.2EDN1, HMOX1, NOS3
31kidney disease10.1NOS3, HMOX1, VCAM1
32allergic asthma10.1NOS1, IL8, VCAM1
33diabetes mellitus, noninsulin-dependent10.1EDN1, VCAM1, PLA2G2A, NOS3
34multiple sclerosis, disease progression, modifier of10.1HLA-DRB1, HLA-DQB1
35microvascular complications of diabetes 310.1NOS3, THBS1, EDN1
36arteriosclerosis10.1NOS3, HMOX1, VCAM1, EDN1
37malaria10.1THBS1, G6PD, VCAM1, HMOX1
38hemoglobin d disease10.0
39acute necrotizing encephalitis10.0
40addison's disease10.0
41aspiration pneumonia10.0
42encephalitis10.0
43influenza10.0
44cor pulmonale10.0
45sickle cell - hemoglobin d disease10.0
46congenital heart disease10.0EDN1, VCAM1, HMOX1, NOS3
47pulmonary fibrosis, idiopathic10.0PLA2G2A, IL8, VCAM1, EDN1
48microvascular complications of diabetes 110.0EDN1, THBS1, VCAM1, IL8
49inflammatory bowel disease10.0HLA-DQB1, VCAM1, IL8, PLA2G2A
50hepatitis b10.0HLA-DQB1, HLA-DRB1, NOS3

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to acute chest syndrome

Symptoms for Acute Chest Syndrome

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Symptoms:

 9 (show all 7)
  • fever
  • pleuritic chest pain
  • tachypnea
  • cough
  • hypoxemia
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

Drugs & Therapeutics for Acute Chest Syndrome

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Drug clinical trials:

Search ClinicalTrials for Acute Chest Syndrome

Search NIH Clinical Center for Acute Chest Syndrome

Genetic Tests for Acute Chest Syndrome

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Anatomical Context for Acute Chest Syndrome

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MalaCards organs/tissues related to Acute Chest Syndrome:

31
Lung, Bone, Bone marrow, Endothelial, Neutrophil, Kidney

Animal Models for Acute Chest Syndrome or affiliated genes

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Publications for Acute Chest Syndrome

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Articles related to Acute Chest Syndrome:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Acute chest syndrome following adenotonsillectomy in a pediatric patient with Hemoglobin SC disease. (25744494)
2015
2
Impact of VEGFA -583Ca88>a88T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease. (25130874)
2014
3
Outcomes of acute chest syndrome in adult patients with sickle cell disease: predictors of mortality. (24740290)
2014
4
Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease. (24340416)
2013
5
Systemic Corticosteroids in Acute Chest Syndrome: Friend or Foe? (24268617)
2013
6
Pulmonary function abnormalities and asthma are prevalent in children with sickle cell disease and are associated with acute chest syndrome. (23301782)
2013
7
Mortality, asthma, smoking and acute chest syndrome in young adults with sickle cell disease. (23149803)
2013
8
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE). (22463614)
2012
9
Feasibility of early diagnosis and treatment of acute chest syndrome in sickle cell anaemia--a case report. (23304961)
2012
10
Risk factors for acute chest syndrome in patients from low socioeconomic background: a cohort study from Sergipe, Brazil. (22034666)
2011
11
How I treat acute chest syndrome in children with sickle cell disease. (21406723)
2011
12
Acute chest syndrome in sickle cell disease due to the new influenza A (H1N1) virus infection. (20169545)
2010
13
The acute chest syndrome of sickle cell disease following aortic valve replacement. (19596703)
2009
14
Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adults. (19309475)
2009
15
Acute chest syndrome in pregnant women with hemoglobin SC disease. (19759888)
2009
16
Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. (18174543)
2008
17
A single-institution experience with treatment of severe acute chest syndrome: lack of rebound pain with dexamethasone plus transfusion therapy. (18391705)
2008
18
Acute chest syndrome during pregnancy as initial presentation of sickle cell disease: a case report. (18756432)
2008
19
Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study. (18815195)
2008
20
Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. (17849474)
2008
21
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms. (17351927)
2007
22
Antibiotics for treating acute chest syndrome in people with sickle cell disease. (17443613)
2007
23
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. (17262858)
2007
24
Sickle cell disease patients in eastern province of Saudi Arabia suffer less severe acute chest syndrome than patients with African haplotypes. (19727367)
2007
25
Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome. (16798640)
2006
26
Transfusion medicine illustrated. Marrow emboli in acute chest syndrome: artifact or etiology? (17002619)
2006
27
Acute chest syndrome in adult sickle cell disease in eastern Saudi Arabia. (15822496)
2005
28
Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease. (15663785)
2005
29
Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. (14687036)
2004
30
Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. (15288680)
2004
31
Induced sputum versus bronchoalveolar lavage during acute chest syndrome in sickle cell disease. (12969866)
2003
32
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. (12368703)
2002
33
Polymerized human Hb use in acute chest syndrome: a case report. (12421214)
2002
34
Acute chest syndrome in sickle cell disease in Saudi Arab Children in the Eastern Province. (17159388)
2002
35
Does splinting from thoracic bone ischemia and infarction contribute to the acute chest syndrome in sickle cell disease? (12114330)
2002
36
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome. (11751185)
2001
37
The role of rib infarcts in the acute chest syndrome of sickle cell diseases. (12673838)
2001
38
The acute chest syndrome of sickle cell disease. (10861328)
2000
39
Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. (11122088)
2000
40
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. (10861320)
2000
41
Acute chest syndrome in sickle cell disease. (11183563)
2000
42
Hemoglobin SC disease presenting as acute chest syndrome with ventilation-perfusion mismatches. (9973696)
1999
43
Endothelial cell nitric oxide production in acute chest syndrome. (10516198)
1999
44
Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. (10579281)
1999
45
Management of sickle cell disease. Acute chest syndrome is common in children before puberty. (9583909)
1998
46
Simultaneous occurrence of rib infarction and pulmonary infiltrates in sickle cell disease patients with acute chest syndrome. (8455078)
1993
47
Acute chest syndrome in sickle cell disease: CT evidence of microvascular occlusion. (8451435)
1993
48
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. (1578502)
1992
49
Evolution of acute chest syndrome in sickle cell trait: an ultrastructural and light microscopic study. (2617448)
1989
50
Acute chest syndrome in sickle cell disease. (3761099)
1986

Variations for Acute Chest Syndrome

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Expression for genes affiliated with Acute Chest Syndrome

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Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for genes affiliated with Acute Chest Syndrome

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Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS3, NOS1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis36
9.9NOS1, NOS3
3
Show member pathways
9.4PLA2G10, PLA2G2A, NOS1, NOS3
49.3NOS3, HMOX1, EDN1
59.2VCAM1, HLA-DRB1, HLA-DQB1
69.1IL8, PLA2G2A, NOS1
78.9IL8, HMOX1, NOS3
8
Show member pathways
8.9PLA2G2A, PLA2G10, HLA-DRB1, HLA-DQB1
98.8NOS1, HLA-DRB1, HLA-DQB1, THBS1
108.7IL8, VCAM1, HBB, THBS1
118.6IL8, HLA-DRB1, HLA-DQB1
12
Show member pathways
8.4EDN1, IL8, PLA2G2A, NOS1, NOS3
13
Show member pathways
8.1HBB, G6PD, PLA2G10, PLA2G2A, HMOX1, NOS1

Compounds for genes affiliated with Acute Chest Syndrome

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Compounds related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1ptio439.8NOS1, HMOX1, NOS3
2adma439.7NOS3, EDN1, NOS1
3apocynin43 5910.7EDN1, VCAM1, NOS1, NOS3
4isosorbide dinitrate43 49 1211.6EDN1, HMOX1, NOS3
5l-nmma439.6NOS3, NOS1, EDN1, VCAM1
6txb2439.6EDN1, THBS1, PLA2G10, PLA2G2A
7zinc protoporphyrin439.6NOS1, HMOX1, G6PD
8n(g)-nitro-l-arginine methyl ester439.5NOS1, NOS3, EDN1
9glycerol43 24 1211.4NOS1, NOS3, PLA2G10, G6PD, PLA2G2A
10alpha tocopherol439.3PLA2G2A, HMOX1, VCAM1, G6PD
11rosiglitazone28 43 49 24 1213.2VCAM1, HMOX1, NOS3, THBS1
12tamoxifen43 49 28 1212.1NOS1, NOS3, VCAM1, G6PD, HBB, THBS1
13ascorbic acid43 2410.0G6PD, NOS3, PLA2G2A, HMOX1, NOS1
14diphenyleneiodonium439.0NOS3, VCAM1, IL8, PLA2G2A, G6PD
1515-deoxy-delta-12,14-prostaglandin j2439.0NOS3, HMOX1, IL8, VCAM1
16atorvastatin43 49 28 24 1213.0HMOX1, VCAM1, THBS1, EDN1, PLA2G2A, NOS3
17prostacyclin438.9THBS1, VCAM1, NOS3, HMOX1, EDN1, PLA2G2A
18fmlp438.9PLA2G2A, PLA2G10, IL8, VCAM1, THBS1
19indomethacin43 28 59 1211.9HMOX1, NOS3, NOS1, PLA2G2A, EDN1
20nadph43 249.9HMOX1, G6PD, VCAM1, PLA2G2A, NOS1, NOS3
21sodium nitroprusside438.9NOS3, NOS1, G6PD, VCAM1, HMOX1, EDN1
22acetylcholine43 49 28 24 1212.9EDN1, PLA2G2A, HMOX1, NOS1, NOS3
23sp 60012543 599.8VCAM1, IL8, THBS1, HMOX1
24pdtc438.7NOS1, HMOX1, PLA2G2A, IL8, VCAM1
258-isoprostane438.7VCAM1, IL8, HMOX1, NOS3, EDN1
26rottlerin438.7VCAM1, EDN1, IL8, HMOX1, NOS3
27s-nitroso-n-acetylpenicillamine438.6EDN1, IL8, HMOX1, NOS1, NOS3
28n acetylcysteine438.5G6PD, HMOX1, PLA2G2A, IL8, VCAM1
29pd 98,059438.5THBS1, VCAM1, EDN1, IL8, NOS3
30ly294002438.5IL8, PLA2G2A, THBS1, HMOX1, NOS3, VCAM1
31doxorubicin43 49 1210.5NOS3, THBS1, G6PD, HMOX1, NOS1
32estrogen438.4G6PD, THBS1, HBB, VCAM1, HMOX1, NOS1
33genistein43 28 59 2 24 1213.3THBS1, EDN1, IL8, PLA2G2A, NOS1, NOS3
34histamine43 28 2410.3HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
35actinomycin d438.3PLA2G2A, HMOX1, NOS3, EDN1, G6PD, IL8
36lactate438.3HMOX1, HBB, G6PD, VCAM1, IL8, PLA2G2A
37cyclosporin a43 28 5910.2IL8, EDN1, THBS1, PLA2G2A, HMOX1, NOS1
38alanine438.2HLA-DRB1, THBS1, VCAM1, PLA2G2A, HMOX1, NOS1
39sb 20358043 599.1EDN1, THBS1, VCAM1, IL8, HMOX1, NOS3
40pge2438.0HMOX1, PLA2G2A, NOS1, IL8, VCAM1, EDN1
41cysteine437.9VCAM1, THBS1, IL8, HBB, PLA2G2A, HMOX1
42dexamethasone43 49 28 1210.9VCAM1, IL8, PLA2G2A, HMOX1, NOS1, THBS1
43arginine437.9EDN1, HLA-DRB1, NOS3, NOS1, HBB, PLA2G2A
44superoxide43 248.9NOS1, VCAM1, IL8, PLA2G2A, HMOX1, NOS3
45cycloheximide437.9HMOX1, PLA2G2A, IL8, HBB, THBS1, EDN1
46serine437.9HBB, G6PD, PLA2G2A, NOS1, THBS1, VCAM1
47vegf437.8HMOX1, EDN1, THBS1, NOS3, VCAM1, PLA2G2A
48h2o2437.7HBB, NOS3, NOS1, HMOX1, G6PD, THBS1
49nitric oxide43 24 129.7NOS1, THBS1, HBB, IL8, HMOX1, VCAM1
50oxygen43 248.3VCAM1, THBS1, EDN1, NOS1, HMOX1, IL8

GO Terms for genes affiliated with Acute Chest Syndrome

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Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.4HLA-DRB1, HLA-DQB1
2endocytic vesicle membraneGO:00306669.1HLA-DQB1, HLA-DRB1, NOS3
3extracellular spaceGO:00056157.9HMOX1, PLA2G2A, IL8, VCAM1, THBS1, EDN1
4extracellular regionGO:00055767.7PLA2G2A, PLA2G10, IL8, HBB, THBS1, EDN1

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrolase activityGO:005134610.3NOS3, NOS1
2arginine catabolic processGO:000652710.2NOS3, NOS1
3positive regulation of guanylate cyclase activityGO:003128410.2NOS3, NOS1
4chronic inflammatory responseGO:000254410.2VCAM1, THBS1
5regulation of systemic arterial blood pressure by endothelinGO:000310010.2NOS3, EDN1
6negative regulation of potassium ion transportGO:004326710.2NOS1, NOS3
7nitric oxide biosynthetic processGO:000680910.1NOS3, NOS1
8positive regulation of macrophage derived foam cell differentiationGO:001074410.1PLA2G10, PLA2G2A
9smooth muscle hyperplasiaGO:001480610.1HMOX1, NOS3
10regulation of blood vessel sizeGO:005088010.1NOS3, HBB
11nitric oxide transportGO:003018510.1HBB, EDN1
12phosphatidylinositol acyl-chain remodelingGO:003614910.1PLA2G10, PLA2G2A
13phosphatidylserine acyl-chain remodelingGO:00361509.9PLA2G10, PLA2G2A
14phosphatidylglycerol acyl-chain remodelingGO:00361489.8PLA2G10, PLA2G2A
15positive regulation of vasodilationGO:00459099.8HMOX1, NOS1, NOS3
16immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.7HLA-DQB1, HLA-DRB1
17humoral immune response mediated by circulating immunoglobulinGO:00024559.7HLA-DRB1, HLA-DQB1
18positive regulation of angiogenesisGO:00457669.7THBS1, HMOX1, NOS3
19regulation of blood pressureGO:00082179.7HBB, HMOX1, NOS3
20response to nicotineGO:00350949.7HMOX1, VCAM1, EDN1
21oxidation-reduction processGO:00551149.7VCAM1, G6PD, HBB
22nitric oxide mediated signal transductionGO:00072639.6NOS1, NOS3
23response to hypoxiaGO:00016669.6NOS1, VCAM1, THBS1, EDN1
24interferon-gamma-mediated signaling pathwayGO:00603339.5VCAM1, HLA-DRB1, HLA-DQB1
25positive regulation of neutrophil chemotaxisGO:00900239.3IL8, EDN1
26blood coagulationGO:00075969.3THBS1, HBB, NOS1, NOS3
27cellular response to tumor necrosis factorGO:00713569.1IL8, VCAM1, THBS1, EDN1
28small molecule metabolic processGO:00442818.7NOS3, HMOX1, PLA2G2A, PLA2G10, G6PD, HBB
29immune responseGO:00069558.5THBS1, HLA-DQB1, HLA-DRB1, IL8

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:000451710.1NOS3, NOS1
2arginine bindingGO:003461810.0NOS1, NOS3
3tetrahydrobiopterin bindingGO:003461710.0NOS1, NOS3
4cadmium ion bindingGO:00468709.9NOS3, NOS1
5FMN bindingGO:00101819.9NOS3, NOS1
6NADPH-hemoprotein reductase activityGO:00039589.8NOS1, NOS3
7NADP bindingGO:00506619.8G6PD, NOS1, NOS3
8heme bindingGO:00200379.2NOS3, NOS1, HMOX1, HBB
9MHC class II receptor activityGO:00323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Acute Chest Syndrome

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Sources for Acute Chest Syndrome

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3CDC
13ExPASy
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22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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38NCIt
39NDF-RT
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56SNOMED-CT via Orphanet
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