Aliases & Classifications for Acute Chest Syndrome

MalaCards integrated aliases for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 51 41 14 69
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 34 517.3
MeSH 41 D056586
SNOMED-CT 64 372146004
UMLS 69 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and asthma, and has symptoms including fever, pleuritic chest pain and tachypnea. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Sweet Taste Signaling and Insulin receptor recycling. The drugs Amodiaquine and Proguanil have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial, and related phenotypes are cardiovascular system and muscle

Wikipedia : 72 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 30.5 HBB VCAM1
2 asthma 29.1 CXCL8 EDN1 PLA2G2A VCAM1
3 jejunoileitis 10.3 NOS1 NOS3
4 toxic myocarditis 10.3 CXCL8 NOS3
5 tetrahydrobiopterin deficiency 10.3 NOS1 NOS3
6 sickle cell anemia 10.3
7 prinzmetal's variant angina 10.2 EDN1 NOS3
8 cytomegalovirus infection 10.2 CXCL8 VCAM1
9 coronary artery vasospasm 10.2 EDN1 NOS3
10 chronic mountain sickness 10.2 EDN1 NOS3
11 episodic pain syndrome, familial, 1 10.1
12 aortic coarctation 10.1 EDN1 NOS3
13 persistent fetal circulation syndrome 10.1 EDN1 NOS3
14 viral encephalitis 10.1 CXCL8 VCAM1
15 hepatic vascular disease 10.1 EDN1 NOS3
16 newborn respiratory distress syndrome 10.1 CXCL8 PLA2G2A
17 meconium aspiration syndrome 10.1 CXCL8 EDN1
18 renovascular hypertension 10.1 EDN1 NOS3
19 peripheral artery disease 10.1 NOS3 VCAM1
20 acute mountain sickness 10.0 EDN1 NOS3
21 malignant secondary hypertension 10.0 EDN1 HBB
22 ischemic optic neuropathy 10.0 EDN1 NOS3
23 hepatopulmonary syndrome 10.0 EDN1 NOS3
24 spinal cord injury 9.9 CXCL8 NOS1 PLA2G2A
25 sexual disorder 9.9 EDN1 NOS1 NOS3
26 impotence 9.9 EDN1 NOS1 NOS3
27 nonarteritic anterior ischemic optic neuropathy 9.9 EDN1 NOS3
28 pulmonary edema 9.9 CXCL8 EDN1 NOS3
29 sleep apnea 9.9 CXCL8 EDN1 NOS3
30 thalassemia 9.9
31 pneumonia 9.9
32 bronchitis 9.9
33 endotheliitis 9.9
34 plastic bronchitis 9.9
35 arteries, anomalies of 9.8 EDN1 NOS3 VCAM1
36 atherosclerosis susceptibility 9.8 EDN1 NOS3 VCAM1
37 limb ischemia 9.8 EDN1 NOS3
38 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
39 thrombosis 9.8
40 ischemia 9.8
41 cerebritis 9.8
42 vascular disease 9.8 EDN1 NOS3 VCAM1
43 pulmonary fibrosis, idiopathic 9.7 CXCL8 EDN1 VCAM1
44 stroke, ischemic 9.7
45 pulmonary hypertension 9.7
46 chlamydia 9.7
47 pre-eclampsia 9.7 EDN1 NOS3 VCAM1
48 aging 9.6
49 beta-thalassemia 9.6
50 aspiration pneumonia 9.6

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

Symptoms:

12
  • fever
  • pleuritic chest pain
  • tachypnea
  • cough
  • hypoxemia
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

UMLS symptoms related to Acute Chest Syndrome:


hoarseness, hemoptysis, dyspnea, coughing, cheyne-stokes respiration, apnea

MGI Mouse Phenotypes related to Acute Chest Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 EDN1 NOS1 NOS3 PLA2G10 THBS1 VCAM1
2 muscle MP:0005369 9.02 EDN1 NOS1 NOS3 PLA2G10 THBS1

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
2
Proguanil Approved Phase 4 500-92-5 4923
3
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
4
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
5 Anti-Infective Agents Phase 4,Phase 2,Phase 1
6 Anti-Bacterial Agents Phase 4,Phase 2
7 Antimalarials Phase 4
8 Antimetabolites Phase 4,Phase 2
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Artemisinine Phase 4
12 Artemisinins Phase 4
13
Dihydroartemisinin Phase 4 71939-50-9 6918483
14 Folic Acid Antagonists Phase 4
15
Piperaquine Phase 4 4085-31-8 5079497
16 Renal Agents Phase 4
17
Nitric Oxide Approved Phase 2, Phase 3,Phase 1 10102-43-9 145068
18
Morphine Approved, Investigational Phase 3 57-27-2 5288826
19
Nalbuphine Approved Phase 3 20594-83-6 5311304 5360630
20
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
21
Dalteparin Approved Phase 3,Phase 2 9005-49-6
22
Heparin Approved, Investigational Phase 3,Phase 2 9005-49-6 46507594 772
23
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
24
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
25 Anti-Asthmatic Agents Phase 2, Phase 3,Phase 1
26 Antioxidants Phase 2, Phase 3,Phase 1
27 Autonomic Agents Phase 2, Phase 3, Phase 1
28 Bronchodilator Agents Phase 2, Phase 3,Phase 1
29 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3,Phase 1
30 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
31 Peripheral Nervous System Agents Phase 2, Phase 3, Phase 1
32 Protective Agents Phase 2, Phase 3,Phase 1
33 Respiratory System Agents Phase 2, Phase 3,Phase 1
34 Vasodilator Agents Phase 2, Phase 3,Phase 1
35 Analgesics Phase 3,Phase 2
36 Analgesics, Opioid Phase 3
37 Central Nervous System Depressants Phase 3,Phase 2
38 Narcotic Antagonists Phase 3
39 Narcotics Phase 3
40 Anesthetics Phase 2, Phase 3
41 Anti-Arrhythmia Agents Phase 2, Phase 3
42 Anticonvulsants Phase 2, Phase 3
43 calcium channel blockers Phase 2, Phase 3
44 Calcium, Dietary Phase 2, Phase 3
45 Tocolytic Agents Phase 2, Phase 3,Phase 1
46 Anticoagulants Phase 3,Phase 2
47 calcium heparin Phase 3,Phase 2
48 Fibrinolytic Agents Phase 3,Phase 2
49 Heparin, Low-Molecular-Weight Phase 3,Phase 2
50 Anti-Inflammatory Agents Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
2 Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
3 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally Completed NCT01380197 Phase 3 Morphine;Nubain
4 Evaluation of Repeat Administration of Purified Poloxamer 188 Completed NCT02449616 Phase 3 MST-188
5 Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Completed NCT01737814 Phase 3 Saline;MST-188
6 Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Completed NCT01197417 Phase 2, Phase 3 Intravenous Magnesium Sulfate;Normal Saline Placebo
7 Therapeutic Anticoagulation Strategy for Acute Chest Syndrome Recruiting NCT02580773 Phase 3 Prophylactic anticoagulation ( INNOHEP®);Curative anticoagulation ( INNOHEP®)
8 Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell Disease Recruiting NCT02433158 Phase 3 Rivipansel
9 Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease Terminated NCT00530270 Phase 3 Dexamethasone;Placebo
10 A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) Terminated NCT01794000 Phase 3 Prasugrel;Placebo
11 IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome Completed NCT00434473 Phase 2 A-001
12 Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children Completed NCT01089439 Phase 2 Nitric oxide by inhalation INOMAX;Placebo
13 Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients Completed NCT00029731 Phase 2 Arginine hydrochloride
14 Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo Completed NCT01419977 Phase 2 Placebo;Dalteparin
15 Treatment of Hemoglobin SC Disease Completed NCT02336373 Phase 2 hydroxyurea
16 A Phase II Trial of Regadenoson in Sickle Cell Anemia Completed NCT01788631 Phase 2 Regadenoson;Placebo
17 Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia Completed NCT00001716 Phase 2 Nitric Oxide;Nitroglycerin
18 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2 Nitric Oxide;Placebo
19 Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome Recruiting NCT02098993 Phase 2 Unfractionated heparin
20 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Recruiting NCT02776202 Phase 2 Fludarabine monophosphate
21 Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease Recruiting NCT02960503 Phase 1, Phase 2 Azithromycin
22 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Adult Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
23 Arginine Therapy for Sickle Cell Disease Pain Recruiting NCT02536170 Phase 2 L-arginine;L-arginine Loading Dose
24 A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients Recruiting NCT02672540 Phase 2 SANGUINATE 320 mg/kg;Normal Saline
25 Vitamin D for Sickle-cell Respiratory Complications Active, not recruiting NCT01443728 Phase 2 Vitamin D3;Vitamin D3
26 A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. Terminated NCT01522196 Phase 2 Varespladib
27 Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE) Terminated NCT02640573 Phase 2 Hydroxyurea
28 Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease Terminated NCT00532883 Phase 2 Hydroxyurea;Magnesium Pidolate
29 Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis Withdrawn NCT01925001 Phase 2 MP4CO;Sodium chloride solution
30 A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome Unknown status NCT02697240 Phase 1 Intravenous citrulline
31 Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial Completed NCT02187445 Phase 1 Budesonide inhalation suspension
32 Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease Completed NCT01895998 Phase 1 Albuterol
33 Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Completed NCT02989701 Phase 1 Plerixafor
34 Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Completed NCT00023296 Phase 1 Nitric Oxide
35 A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease Recruiting NCT02630394 Phase 1 Azithromycin
36 Bi-Level Positive Airway Ventilation for Acute Chest Syndrome Unknown status NCT01589926
37 Preventing Acute Chest Syndrome by Transfusion Feasibility Study Completed NCT00951808
38 Role of Placenta Growth Factor in Sickle Acute Chest Syndrome Completed NCT00448370
39 ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician? Completed NCT01041339
40 Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia Completed NCT02565849
41 Molecular Phenotyping of Asthma in Sickle Cell Disease Completed NCT01879592
42 Sickle Cell Disease and Endothelial Progenitor Cells (EPCs) Completed NCT00783627
43 Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe. Completed NCT03368261
44 Evaluation of a Training Program for Homozygous Sickle Cell Disease Patients Completed NCT02571088
45 Validation of a Predictive Score of Acute Chest Syndrome Recruiting NCT03032055
46 sPLA2 in EBC During Acute Chest Syndrome Recruiting NCT03250585
47 Acute Kidney Injury in Patients With Sickle Cell Disease Recruiting NCT03105271
48 Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization. Recruiting NCT03111589
49 Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease Recruiting NCT02225132 Early Phase 1 Hydroxyurea
50 Novel Dose Escalation to Predict Treatment With Hydroxyurea Recruiting NCT02042222 Early Phase 1 Hydroxyurea

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

38
Lung, Bone, Endothelial, Bone Marrow, Kidney, Monocytes, Placenta

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 259)
# Title Authors Year
1
Comprehensive management reduces incidence and mortality of acute chest syndrome in patients with sickle cell disease. ( 29205462 )
2018
2
Acute chest syndrome among children hospitalized with vaso-occlusive crisis: A nationwide study in the United States. ( 29134776 )
2018
3
Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia. ( 29363738 )
2018
4
Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. ( 29356722 )
2018
5
Recurrent Acute Chest Syndrome in Pediatric Sickle Cell Disease: Clinical Features and Risk Factors. ( 29200151 )
2018
6
Extracorporeal Lung Support in Acute Chest Syndrome Associated With Sickle Cell Disease: A Rare Report of a Common Case. ( 28703372 )
2017
7
Acute Splenic Sequestration Crisis After Red Blood Cell Exchange for Acute Chest Syndrome in an Adult With Sickle I^-Thalassemia: What Went Wrong? ( 29205801 )
2017
8
Plastic bronchitis: An unusual complication of acute chest syndrome in adult. ( 28443234 )
2017
9
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. ( 28486752 )
2017
10
A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. ( 28905364 )
2017
11
Association of Guideline-Adherent Antibiotic Treatment With Readmission of Children With Sickle Cell Disease Hospitalized With Acute Chest Syndrome. ( 28892533 )
2017
12
Association of plasma CD40L with acute chest syndrome in sickle cell anemia. ( 28609750 )
2017
13
Acute Chest Syndrome in Children with Sickle Cell Disease. ( 29279787 )
2017
14
Inflammatory and endothelial markers during vaso-occlusive crisis and acute chest syndrome in sickle cell disease. ( 28741692 )
2017
15
Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. ( 26936083 )
2016
16
Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome. ( 27397962 )
2016
17
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. ( 27353685 )
2016
18
Acute Chest Syndrome, Asthma, and Lung Function in Sickle Cell Disease. Which Is the Chicken, and Which Is the Egg? ( 27509149 )
2016
19
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. ( 27574910 )
2016
20
Accuracy of Point-of-Care Lung Ultrasonography for Diagnosis of Acute Chest Syndrome in Pediatric Patients with Sickle Cell Disease and Fever. ( 27155438 )
2016
21
Rapidly progressive acute chest syndrome in individuals with sickle cell anemia. ( 27543812 )
2016
22
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. ( 27011218 )
2016
23
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients. ( 27412264 )
2016
24
Bedside Lung Ultrasound During Acute Chest Syndrome in Sickle Cell Disease. ( 26886600 )
2016
25
Sickle cell crisis - Acute chest syndrome. ( 27728299 )
2016
26
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome. ( 27957377 )
2016
27
Are We Missing the Mark? Fever, Respiratory Symptoms, Chest Radiographs and Acute Chest Syndrome in Sickle Cell Disease. ( 27153121 )
2016
28
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 27673392 )
2016
29
387: CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH ACUTE CHEST SYNDROME AT A CHILDREN'S HOSPITAL ICU. ( 26570048 )
2015
30
Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. ( 26033266 )
2015
31
Casting a shadow. A 13-year-old girl with acute chest syndrome and respiratory failure. ( 26203611 )
2015
32
Inhaled nitric oxide for acute chest syndrome in adult sickle cell patients: a randomized controlled study. ( 26431718 )
2015
33
Guideline on the management of acute chest syndrome in sickle cell disease. ( 25824256 )
2015
34
Antibiotics for treating acute chest syndrome in people with sickle cell disease. ( 25749695 )
2015
35
Platelets Decline during Vaso-Occlusive Crisis as a Predictor of Acute Chest Syndrome in Sickle Cell Disease. ( 26453077 )
2015
36
Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome. ( 26130498 )
2015
37
Radiographic patterns of acute chest syndrome. ( 25870181 )
2015
38
Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome. ( 25950690 )
2015
39
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient. ( 26327979 )
2015
40
A case of acute chest syndrome complicated by diffuse cerebral infarcts in an adult with HbSI^-thalassemia(.). ( 26088144 )
2015
41
Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort. ( 25619382 )
2015
42
Age-dependent pathophysiology of acute chest syndrome in children with sickle cell disease. ( 25683565 )
2015
43
Acute chest syndrome following adenotonsillectomy in a pediatric patient with Hemoglobin SC disease. ( 25744494 )
2015
44
Pulmonary Platelet Thrombi and Vascular Pathology in Acute Chest Syndrome in Patients with Sickle Cell Disease. ( 26492581 )
2015
45
Adjunctive therapy with inhaled nitric oxide for severe acute chest syndrome in patients with sickle cell disease. ( 26431719 )
2015
46
The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks. ( 26060589 )
2015
47
The Acute Chest Syndrome in Cameroonian children living with sickle cell disease. ( 26391669 )
2015
48
Associated factors of acute chest syndrome in children with sickle cell disease in French Guiana. ( 24678322 )
2014
49
Impact of VEGFA -583Ca88>a88T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease. ( 25130874 )
2014
50
Acute chest syndrome in severity of sickle cell diseases. ( 25664108 )
2014

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 NOS1 NOS3 PLA2G10 PLA2G2A
2
Show member pathways
12.21 CXCL8 NOS1 NOS3
3 11.72 EDN1 NOS3 VCAM1
4 11.58 CXCL8 NOS1 PLA2G2A
5
Show member pathways
11.29 PLA2G10 PLA2G2A
6 11.25 CXCL8 EDN1 NOS3 VCAM1
7 11.23 NOS3 VCAM1
8
Show member pathways
11.2 PLA2G10 PLA2G2A
9 11.19 CXCL8 VCAM1
10
Show member pathways
11.16 NOS1 NOS3
11
Show member pathways
11.13 NOS1 NOS3
12 11.05 HBB VCAM1
13 11.03 EDN1 NOS3
14 11.01 CXCL8 NOS3
15
Show member pathways
10.87 NOS1 NOS3
16 10.81 NOS1 NOS3
17 10.78 NOS1 NOS3 PLA2G2A
18 10.61 CXCL8 HBB THBS1 VCAM1
19 10.48 NOS1 NOS3
20 10.16 NOS1 NOS3

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CXCL8 EDN1 HBB PLA2G10 PLA2G2A THBS1
2 extracellular space GO:0005615 9.17 CXCL8 EDN1 HBB PLA2G10 PLA2G2A THBS1

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.72 CXCL8 NOS3 THBS1
2 positive regulation of endothelial cell migration GO:0010595 9.66 EDN1 THBS1
3 response to heat GO:0009408 9.66 NOS1 NOS3
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 EDN1 HBB
5 phosphatidic acid biosynthetic process GO:0006654 9.65 PLA2G10 PLA2G2A
6 response to nicotine GO:0035094 9.65 EDN1 VCAM1
7 positive regulation of blood vessel endothelial cell migration GO:0043536 9.64 NOS3 THBS1
8 response to testosterone GO:0033574 9.64 EDN1 THBS1
9 negative regulation of blood pressure GO:0045776 9.63 NOS1 NOS3
10 positive regulation of neutrophil chemotaxis GO:0090023 9.63 CXCL8 EDN1
11 phosphatidylcholine acyl-chain remodeling GO:0036151 9.62 PLA2G10 PLA2G2A
12 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.62 PLA2G10 PLA2G2A
13 arachidonic acid secretion GO:0050482 9.61 PLA2G10 PLA2G2A
14 vasodilation GO:0042311 9.61 NOS1 NOS3
15 phosphatidylserine acyl-chain remodeling GO:0036150 9.6 PLA2G10 PLA2G2A
16 regulation of sodium ion transport GO:0002028 9.59 NOS1 NOS3
17 phosphatidylglycerol acyl-chain remodeling GO:0036148 9.58 PLA2G10 PLA2G2A
18 nitric oxide mediated signal transduction GO:0007263 9.58 NOS1 NOS3
19 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.57 PLA2G10 PLA2G2A
20 phosphatidylinositol acyl-chain remodeling GO:0036149 9.56 PLA2G10 PLA2G2A
21 nitric oxide biosynthetic process GO:0006809 9.54 NOS1 NOS3
22 negative regulation of calcium ion transport GO:0051926 9.52 NOS1 NOS3
23 positive regulation of guanylate cyclase activity GO:0031284 9.51 NOS1 NOS3
24 regulation of blood pressure GO:0008217 9.5 EDN1 HBB NOS3
25 negative regulation of potassium ion transport GO:0043267 9.49 NOS1 NOS3
26 chronic inflammatory response GO:0002544 9.48 THBS1 VCAM1
27 positive regulation of prostaglandin secretion GO:0032308 9.46 EDN1 PLA2G10
28 response to hypoxia GO:0001666 9.46 EDN1 NOS1 THBS1 VCAM1
29 arginine catabolic process GO:0006527 9.43 NOS1 NOS3
30 negative regulation of hydrolase activity GO:0051346 9.4 NOS1 NOS3
31 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.37 EDN1 NOS3
32 nitric oxide transport GO:0030185 9.26 EDN1 HBB
33 cellular response to tumor necrosis factor GO:0071356 9.26 CXCL8 EDN1 THBS1 VCAM1
34 regulation of blood vessel size GO:0050880 8.8 EDN1 HBB NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.61 HBB NOS1 NOS3
2 heme binding GO:0020037 9.58 HBB NOS1 NOS3
3 NADP binding GO:0050661 9.51 NOS1 NOS3
4 phospholipase A2 activity GO:0004623 9.49 PLA2G10 PLA2G2A
5 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) GO:0102567 9.48 PLA2G10 PLA2G2A
6 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) GO:0102568 9.46 PLA2G10 PLA2G2A
7 FMN binding GO:0010181 9.37 NOS1 NOS3
8 arginine binding GO:0034618 9.32 NOS1 NOS3
9 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
10 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS1 NOS3
11 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS3
12 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Acute Chest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....