MCID: ACT036
MIFTS: 32

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 47 C35334
SNOMED-CT 64 6215006
UMLS 69 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to ascending cholangitis and cholangitis. An important gene associated with Acute Cholangitis is IL6 (Interleukin 6), and among its related pathways/superpathways are IL6-mediated signaling events and Interleukin-10 signaling. The drugs Amoxicillin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and neutrophil.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 ascending cholangitis 10.9
2 cholangitis 10.7
3 vagina leiomyosarcoma 10.5 IL1RN IL6
4 indolent myeloma 10.5 IL1RN IL6
5 orthostatic proteinuria 10.5 IL1RN IL6
6 keloids 10.5 IL1RN IL6
7 noma 10.5 IL1RN IL6
8 osmotic diarrhea 10.5 IL1RN IL6
9 collagenopathy type 2 alpha 1 10.4 CRP IL6
10 iida kannari syndrome 10.4 IL1RN IL6
11 brachydactyly-distal symphalangism syndrome 10.4 CRP IL6
12 epstein-barr virus hepatitis 10.4 CRP IL6
13 x-linked dominant intellectual disability-epilepsy syndrome 10.4 CRP IL6
14 erythema elevatum diutinum 10.4 CRP IL6
15 cataract congenital autosomal dominant 10.4 CRP IL6
16 chronic diarrhea due to guanylate cyclase 2c overactivity 10.4 CRP IL6
17 malignant gastric granular cell tumor 10.4 CRP IL6
18 nodular nonsuppurative panniculitis 10.4 CRP IL6
19 hemangioma of spleen 10.4 CRP IL6
20 central nervous system leiomyosarcoma 10.4 CRP IL6
21 lung occult large cell carcinoma 10.4 CRP IL6
22 cicatricial lagophthalmos 10.4 CRP IL6
23 ariboflavinosis 10.4 CRP IL6
24 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.4 CRP IL6
25 islet cell tumor 10.4 CRP IL6
26 queensland tick typhus 10.4 CRP IL6
27 placental abruption 10.4 CRP IL6
28 luxation of globe 10.4 CRP IL6
29 parasitic helminthiasis infectious disease 10.4 CRP IL6
30 allergic bronchopulmonary aspergillosis 10.4 CRP IL6
31 autosomal recessive type iv ehlers-danlos syndrome 10.4 IL1RN IL6
32 hyperlipoproteinemia type iv 10.4 CRP IL6
33 partial central choroid dystrophy 10.4 CRP IL6
34 breast papillary carcinoma 10.4 CRP IL6
35 myeloid sarcoma 10.4 CRP IL6
36 pneumoconiosis 10.4 CRP IL6
37 porokeratosis 3, multiple types 10.4 CRP IL1RN
38 plummer's disease 10.4 CRP IL6
39 cerebral hemorrhage 10.4 CRP IL1RN
40 residual stage corticosteroid-induced glaucoma 10.4 CRP IL6
41 c1 inhibitor deficiency 10.4 CRP IL6
42 breast disease 10.4 CRP IL6
43 bardet-biedl syndrome 8 10.4 CRP IL6
44 brain glioblastoma multiforme 10.4 CRP IL6
45 pleomorphic lipoma 10.4 IL1RN IL6
46 focal dystonia 10.4 CRP IL6
47 ischemic heart disease 10.4 CRP IL6
48 urinary bladder posterior wall cancer 10.4 CRP IL6
49 pyrimidine metabolic disorder 10.4 CRP IL1RN
50 atrophy of prostate 10.4 CRP IL6

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2 Anti-Bacterial Agents Phase 4
3 Antibiotics, Antitubercular Phase 4
4 Anti-Infective Agents Phase 4
5
Menthol Approved 2216-51-5 16666
6
Meperidine Approved 57-42-1 4058
7
Midazolam Approved, Illicit 59467-70-8 4192
8 Butylscopolammonium Bromide
9 Scopolamine hydrobromide 114-49-8

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Recruiting NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
2 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
3 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
4 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582
5 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
6 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417
7 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569
8 RFA for Malignant Biliary Obstruction Recruiting NCT03166436
9 Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications Recruiting NCT02510495
10 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474
11 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
12 The Effect of Different Duration of Bolloon Dilation During ESBD Not yet recruiting NCT02958618
13 Results of Bile and Blood Culture in Patients With Acute Cholangitis Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

39
Liver, Lung, Neutrophil, Myeloid

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 251)
id Title Authors Year
1
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
2
Acute Cholangitis After Bilioenteric Anastomosis for Bile Duct Injuries. ( 28744740 )
2017
3
Comparison of acute cholangitis with or without common bile duct dilatation. ( 28587432 )
2017
4
Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. ( 28419764 )
2017
5
Endoscopic-ultrasonography-guided biliary drainage for repetitive acute cholangitis of the accessory hepatic duct obstructed by clipping during laparoscopic cholecystectomy. ( 28381783 )
2017
6
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
7
Endoscopic Retrograde Cholangiopancreatography (ERCP) and Acute Cholangitis: The Sooner, the Better. ( 28697150 )
2017
8
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2017
9
Endoscopic management of acute cholangitis according to the TG13. ( 28425666 )
2017
10
Acquired Leukocyte Inclusion Bodies Resembling DAPhle Bodies During Acute Cholangitis. ( 28747290 )
2017
11
Management of acute cholangitis as a result of occlusion from a self-expandable metallic stent in patients with malignant distal and hilar biliary obstructions. ( 28425663 )
2017
12
Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )
2017
13
Is addition of endoscopic sphincterotomy before endoscopic biliary drainage necessary for acute cholangitis as a result of common bile duct stones? ( 28425654 )
2017
14
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. ( 28941329 )
2017
15
Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28076388 )
2017
16
Platelet hyperaggregability is associated with decreased ADAMTS13 activity and enhanced endotoxemia in patients with acute cholangitis. ( 28628948 )
2017
17
Current strategies for endoscopic management of acute cholangitis. ( 28425650 )
2017
18
Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo guidelines 2018. ( 28834389 )
2017
19
Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis. ( 28371094 )
2017
20
Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis. ( 28798923 )
2017
21
Endoscopic management of acute cholangitis as a result of common bile duct stones. ( 28425658 )
2017
22
Can endoscopic stone retraction be carried out even in cases with severe acute cholangitis? ( 28425647 )
2017
23
Acute cholangitis in an old patient with Crigler-Najjar syndrome type II - a case report. ( 26968162 )
2016
24
Controversy and progress for treatment of acute cholangitis after Tokyo Guidelines (TG13). ( 26961212 )
2016
25
Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study. ( 27783206 )
2016
26
Bacteremia due to Arthrobacter creatinolyticus in an elderly diabetic man with acute cholangitis. ( 27357988 )
2016
27
Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients. ( 27919851 )
2016
28
Mortality Risk for Acute Cholangitis (MAC): a risk prediction model for in-hospital mortality in patients with acute cholangitis. ( 26860903 )
2016
29
Short-course antimicrobial treatment for acute cholangitis with Gram-negative bacillary bacteremia. ( 28027992 )
2016
30
IL-7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis. ( 28002647 )
2016
31
Acute Cholangitis Management: Prevention of Organ Failure and Death. ( 27556590 )
2016
32
Usefulness of the Delta Neutrophil Index as a Promising Prognostic Marker of Acute Cholangitis in Emergency Departments. ( 27559701 )
2016
33
Liver Hydatid Cyst and Acute Cholangitis: a Case Report. ( 27309273 )
2016
34
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. ( 27875357 )
2016
35
Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly. ( 27729744 )
2016
36
Association of Admission Laboratory Values and the Timing of Endoscopic Retrograde Cholangiopancreatography With Clinical Outcomes in Acute Cholangitis. ( 27557050 )
2016
37
Acute cholangitis: An unexpected cause of fever of unknown origin diagnosed by (18)F-FDG PET/CT. ( 27033744 )
2016
38
Role of Presepsin for the Assessment of Acute Cholangitis Severity. ( 27215088 )
2016
39
Letter: acute cholangitis: understanding predictors of outcome--authors' reply. ( 26278564 )
2015
40
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. ( 26668810 )
2015
41
Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation. ( 25593469 )
2015
42
Hepatocellular carcinoma with bile duct invasion presenting as acute cholangitis. ( 26140647 )
2015
43
Comparison Between Endoscopic Biliary Stenting and Nasobiliary Drainage in Patients with Acute Cholangitis due to Choledocholithiasis: Is Endoscopic Biliary Stenting Useful? ( 26897928 )
2015
44
Acute Cholangitis following Intraductal Migration of Surgical Clips 10 Years after Laparoscopic Cholecystectomy. ( 25874138 )
2015
45
Early versus delayed laparoscopic common bile duct exploration for common bile duct stone-related nonsevere acute cholangitis. ( 26123122 )
2015
46
Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. ( 25997554 )
2015
47
Severe Acute Cholangitis with Complications of Bacterial Meningitis Associated with Hearing Loss. ( 26179531 )
2015
48
HEPATOCELLULAR CARCINOMA WITH BILE DUCT INVASION PRESENTING AS ACUTE CHOLANGITIS. ( 26045307 )
2015
49
Letter: acute cholangitis--understanding predictors of outcome. ( 26278563 )
2015
50
Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. ( 25672751 )
2015

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.09 CRP IL6
2 10.65 IL1RN IL6
3 9.9 CRP IL6

GO Terms for Acute Cholangitis

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 CRP IL1RN IL6
2 defense response to Gram-positive bacterium GO:0050830 9.37 CRP IL6
3 response to glucocorticoid GO:0051384 9.32 IL1RN IL6
4 acute-phase response GO:0006953 9.16 CRP IL6
5 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
6 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 8.62 IL1RN IL6

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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