MCID: ACT036
MIFTS: 35

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 46 C35334
SNOMED-CT 64 6215006
UMLS 69 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to cholangitis and toxic shock syndrome. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are IL-6 signaling pathway and Interleukin-10 signaling. The drugs Menthol and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and lung.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.2 CRP IL6
2 toxic shock syndrome 29.9 IL6 TREM1
3 melioidosis 29.8 IL6 TREM1
4 acute pancreatitis 29.5 CRP IL6
5 bacterial meningitis 29.5 CRP IL6
6 meningitis 29.3 CRP IL6
7 kawasaki disease 29.2 CRP IL6
8 ascending cholangitis 11.0
9 crimean-congo hemorrhagic fever 10.3 IL6 TREM1
10 osteosclerotic myeloma 10.2 IL1RN IL6
11 necrotizing fasciitis 10.2 IL1RN IL6
12 cholecystitis 10.2
13 hydrarthrosis 10.2 IL1RN IL6
14 joint disorders 10.2 IL1RN IL6
15 aphthous stomatitis 10.2 IL1RN IL6
16 dengue shock syndrome 10.2 IL1RN IL6
17 idiopathic neutropenia 10.2 IL1RN IL6
18 aggressive periodontitis 10.2 IL1RN IL6
19 cold agglutinin disease 10.2 CRP IL6
20 diabetic foot ulcers 10.2 CRP IL6
21 suppurative cholangitis 10.2 CRP TREM1
22 neutrophilia, hereditary 10.2 CRP IL6
23 cardiogenic shock 10.2 CRP IL6
24 uremic pruritus 10.2 CRP IL6
25 spinal disease 10.2 CRP IL6
26 castleman disease 10.2 CRP IL6
27 angina pectoris 10.2 CRP IL6
28 viral pneumonia 10.2 CRP IL6
29 cecal disease 10.2 CRP IL6
30 central nervous system vasculitis 10.2 CRP IL6
31 subacute thyroiditis 10.2 CRP IL6
32 intussusception 10.2 CRP IL6
33 louse-borne relapsing fever 10.2 CRP IL6
34 hypersensitivity reaction type iii disease 10.2 CRP IL6
35 multicentric castleman disease 10.2 CRP IL6
36 ischemic heart disease 10.2 CRP IL6
37 mesenteric lymphadenitis 10.2 CRP IL6
38 systolic heart failure 10.2 CRP IL6
39 osteomyelitis 10.2 IL1RN IL6
40 intermittent explosive disorder 10.2 CRP IL6
41 intermediate coronary syndrome 10.2 CRP IL6
42 prediabetes syndrome 10.2 CRP IL6
43 acute cystitis 10.2 CRP IL6
44 polyarteritis nodosa 10.2 CRP IL6
45 acute pyelonephritis 10.1 CRP IL6
46 apnea, obstructive sleep 10.1 CRP IL6
47 perinatal necrotizing enterocolitis 10.1 CRP IL6
48 viral meningitis 10.1 CRP IL6
49 lymph node disease 10.1 CRP IL6
50 infective endocarditis 10.1 CRP IL6

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved 2216-51-5 16666
2
Meperidine Approved 57-42-1 4058
3
Midazolam Approved, Illicit 59467-70-8 4192
4 Anti-Bacterial Agents
5 Antibiotics, Antitubercular
6 Anti-Infective Agents
7 Antitubercular Agents
8 Butylscopolammonium Bromide
9 Scopolamine hydrobromide 114-49-8

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
2 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
3 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582
4 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
5 Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications Completed NCT02510495
6 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417
7 Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis Recruiting NCT03422042
8 Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures Recruiting NCT03353181
9 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569
10 RFA for Malignant Biliary Obstruction Recruiting NCT03166436
11 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474
12 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
13 The Effect of Different Duration of Bolloon Dilation During ESBD Not yet recruiting NCT02958618
14 Results of Bile and Blood Culture in Patients With Acute Cholangitis Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

38
Liver, Neutrophil, Lung, Myeloid

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 262)
# Title Authors Year
1
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). ( 29032610 )
2018
2
Clinical applicability of Tokyo guidelines 2018/2013 in diagnosis and severity evaluation of acute cholangitis and determination of a new severity model. ( 29374984 )
2018
3
Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. ( 29090868 )
2018
4
Re: Acute cholangitis: current concepts. ( 29392900 )
2018
5
Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29090866 )
2018
6
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
7
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
8
Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis. ( 29334699 )
2018
9
Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo guidelines 2018. ( 28834389 )
2017
10
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
11
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2017
12
Platelet hyperaggregability is associated with decreased ADAMTS13 activity and enhanced endotoxemia in patients with acute cholangitis. ( 28628948 )
2017
13
Acquired Leukocyte Inclusion Bodies Resembling DAPhle Bodies During Acute Cholangitis. ( 28747290 )
2017
14
Endoscopic management of acute cholangitis as a result of common bile duct stones. ( 28425658 )
2017
15
Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. ( 28419764 )
2017
16
Case Report: Biliary Pancreatitis With Acute Cholangitis in a Patient Under Anticoagulant Treatment With Dabigatran. ( 29075173 )
2017
17
Comparison of acute cholangitis with or without common bile duct dilatation. ( 28587432 )
2017
18
Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28076388 )
2017
19
Current strategies for endoscopic management of acute cholangitis. ( 28425650 )
2017
20
Endoscopic-ultrasonography-guided biliary drainage for repetitive acute cholangitis of the accessory hepatic duct obstructed by clipping during laparoscopic cholecystectomy. ( 28381783 )
2017
21
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. ( 28941329 )
2017
22
Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )
2017
23
Can endoscopic stone retraction be carried out even in cases with severe acute cholangitis? ( 28425647 )
2017
24
A case report of patient with severe acute cholangitis with tigecycline treatment causing coagulopathy and hypofibrinogenemia. ( 29245350 )
2017
25
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
26
Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis. ( 28371094 )
2017
27
Endoscopic Retrograde Cholangiopancreatography (ERCP) and Acute Cholangitis: The Sooner, the Better. ( 28697150 )
2017
28
Evaluation and Comparison of Charcot's Triad and Tokyo Guidelines for the Diagnosis of Acute Cholangitis. ( 29089703 )
2017
29
Is addition of endoscopic sphincterotomy before endoscopic biliary drainage necessary for acute cholangitis as a result of common bile duct stones? ( 28425654 )
2017
30
Management of acute cholangitis as a result of occlusion from a self-expandable metallic stent in patients with malignant distal and hilar biliary obstructions. ( 28425663 )
2017
31
Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis. ( 28798923 )
2017
32
Acute Cholangitis After Bilioenteric Anastomosis for Bile Duct Injuries. ( 28744740 )
2017
33
Endoscopic management of acute cholangitis according to the TG13. ( 28425666 )
2017
34
Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients. ( 27919851 )
2016
35
Association of Admission Laboratory Values and the Timing of Endoscopic Retrograde Cholangiopancreatography With Clinical Outcomes in Acute Cholangitis. ( 27557050 )
2016
36
Usefulness of the Delta Neutrophil Index as a Promising Prognostic Marker of Acute Cholangitis in Emergency Departments. ( 27559701 )
2016
37
IL-7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis. ( 28002647 )
2016
38
Acute Cholangitis Management: Prevention of Organ Failure and Death. ( 27556590 )
2016
39
Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study. ( 27783206 )
2016
40
Controversy and progress for treatment of acute cholangitis after Tokyo Guidelines (TG13). ( 26961212 )
2016
41
Acute cholangitis in an old patient with Crigler-Najjar syndrome type II - a case report. ( 26968162 )
2016
42
Short-course antimicrobial treatment for acute cholangitis with Gram-negative bacillary bacteremia. ( 28027992 )
2016
43
Mortality Risk for Acute Cholangitis (MAC): a risk prediction model for in-hospital mortality in patients with acute cholangitis. ( 26860903 )
2016
44
Liver Hydatid Cyst and Acute Cholangitis: a Case Report. ( 27309273 )
2016
45
Acute cholangitis: An unexpected cause of fever of unknown origin diagnosed by (18)F-FDG PET/CT. ( 27033744 )
2016
46
Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly. ( 27729744 )
2016
47
Role of Presepsin for the Assessment of Acute Cholangitis Severity. ( 27215088 )
2016
48
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. ( 27875357 )
2016
49
Bacteremia due to Arthrobacter creatinolyticus in an elderly diabetic man with acute cholangitis. ( 27357988 )
2016
50
Weekend Admission for Acute Cholangitis Does Not Adversely Impact Clinical or Endoscopic Outcomes. ( 26391268 )
2015

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.09 CRP IL6
2 10.65 IL1RN IL6
3 9.9 CRP IL6

GO Terms for Acute Cholangitis

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 CRP IL1RN IL6
2 defense response to Gram-positive bacterium GO:0050830 9.4 CRP IL6
3 response to glucocorticoid GO:0051384 9.37 IL1RN IL6
4 humoral immune response GO:0006959 9.32 IL6 TREM1
5 acute-phase response GO:0006953 9.16 CRP IL6
6 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
7 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 8.62 IL1RN IL6

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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