Aliases & Classifications for Acute Cystitis

MalaCards integrated aliases for Acute Cystitis:

Name: Acute Cystitis 12 14 69
Urinary Tract Infection 12 69
Recurrent Urinary Tract Infection 69
Urinary Tract Infections 40

Classifications:



External Ids:

Disease Ontology 12 DOID:13148
ICD10 32 N30.0 N39.0
ICD9CM 34 595.0
NCIt 46 C26934

Summaries for Acute Cystitis

MedlinePlus : 40 The urinary system is the body's drainage system for removing wastes and extra water. It includes two kidneys, two ureters, a bladder, and a urethra. Urinary tract infections (UTIs) are the second most common type of infection in the body. You may have a UTI if you notice Pain or burning when you urinate Fever, tiredness, or shakiness An urge to urinate often Pressure in your lower belly Urine that smells bad or looks cloudy or reddish Pain in your back or side below the ribs People of any age or sex can get UTIs. But about four times as many women get UTIs as men. You're also at higher risk if you have diabetes, need a tube to drain your bladder, or have a spinal cord injury. If you think you have a UTI it is important to see your doctor. Your doctor can tell if you have a UTI with a urine test. Treatment is with antibiotics. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Acute Cystitis, also known as urinary tract infection, is related to cystitis and bacteriuria, and has symptoms including uti symptoms, pruritus and fever. An important gene associated with Acute Cystitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Immune response IL-23 signaling pathway. The drugs Ibuprofen and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord.

Disease Ontology : 12 A cystitis characterized by a sudden onset or severe symptoms.

Wikipedia : 72 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Acute Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Acute Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 cystitis 32.1 CRP CXCL8 IL6 UPK1A
2 bacteriuria 30.4 CXCL8 IL18 IL6
3 acute pyelonephritis 29.7 ALB CRP CXCL8 IL6
4 pyelonephritis 29.7 ALB CCL2 CRP CXCL8 IL6
5 meningitis 29.2 ALB CCL2 CRP CXCL1 CXCL8 IL6
6 urinary tract infections, recurrent 12.5
7 neonatal urinary tract infectious disease 11.5
8 cold agglutinin disease 10.6 CRP IL6
9 diabetic foot ulcers 10.5 CRP IL6
10 cryopyrin-associated periodic syndrome 10.5 CRP IL6
11 neutrophilia, hereditary 10.5 CRP IL6
12 acute cholangitis 10.5 CRP IL6
13 stachybotrys chartarum 10.5 CCL2 IL18 IL6
14 cardiogenic shock 10.5 CRP IL6
15 retinitis pigmentosa 73 10.5 CCL2 CXCL1
16 uremic pruritus 10.4 CRP IL18 IL6
17 ischemic heart disease 10.4 CCL2 CRP IL6
18 recurrent corneal erosion 10.4 CXCL8 IL6
19 bagassosis 10.4 CXCL8 IL6
20 adult-onset still's disease 10.4 CRP IL18 IL6
21 peripheral artery disease 10.4 CCL2 CRP IL6
22 herpes simplex virus keratitis 10.4 CCL2 CXCL8
23 neonatal hypothyroidism 10.4 ADCY10 SLC5A5
24 temporal arteritis 10.4 CCL2 CRP IL6
25 relapsing-remitting multiple sclerosis 10.4 CCL2 IL18 IL6
26 acute transverse myelitis 10.4 CXCL8 IL6
27 aortic aneurysm, familial abdominal, 1 10.4 CCL2 CRP IL6
28 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6
29 juvenile rheumatoid arthritis 10.4 CRP IL18 IL6
30 overnutrition 10.4 CCL2 CRP IL6
31 israeli tick typhus 10.4 CCL2 CXCL8
32 denture stomatitis 10.3 CCL2 CXCL8 IL6
33 spinal disease 10.3 CRP IL6
34 viral encephalitis 10.3 CCL2 CXCL8 IL6
35 hypersensitivity reaction type iii disease 10.3 ALB CRP IL6
36 pulpitis 10.3 CXCL8 IL18 IL6
37 slow-channel congenital myasthenic syndrome 10.3 CRP CXCL8
38 atherosclerosis susceptibility 10.3 CCL2 CRP IL6
39 prediabetes syndrome 10.3 ALB CRP IL6
40 pleural tuberculosis 10.3 CCL2 CXCL8 IL18
41 fasciitis 10.3 CXCL8 IL18 IL6
42 hemorrhagic fever with renal syndrome 10.3 ALB CRP IL6
43 urethral calculus 10.3 KLK3 MCU
44 intermittent claudication 10.3 ALB CRP IL6
45 typhoid fever 10.3 ALB CRP IL6
46 coronary stenosis 10.3 ALB CRP IL6
47 pneumoconiosis 10.3 CCL2 CXCL8 IL6
48 iga glomerulonephritis 10.3 ALB CCL2 IL6
49 louse-borne relapsing fever 10.3 CRP CXCL8 IL6
50 primary bacterial infectious disease 10.3 ALB CRP IL6

Comorbidity relations with Acute Cystitis via Phenotypic Disease Network (PDN): (show top 50) (show all 439)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Anterolateral Myocardial Infarction
Acute Conjunctivitis Acute Cor Pulmonale
Acute Kidney Failure Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Sphenoidal Sinusitis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Age-Related Hearing Loss
Alcohol Abuse Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Algoneurodystrophy Allergic Urticaria
Alopecia, Neurologic Defects, and Endocrinopathy Syndrome Alzheimer Disease
Amnestic Disorder Amyloidosis
Anemia, Autoimmune Hemolytic Anus Cancer
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Asthma Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Bacterial Meningitis Balanoposthitis
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Biliary Tract Disease
Bipolar Disorder Bladder Cancer
Bladder Disease Bladder Neck Obstruction
Bleeding Disorder, Platelet-Type, 11 Blepharitis

Graphical network of the top 20 diseases related to Acute Cystitis:



Diseases related to Acute Cystitis

Symptoms & Phenotypes for Acute Cystitis

UMLS symptoms related to Acute Cystitis:


uti symptoms, pruritus, fever

Drugs & Therapeutics for Acute Cystitis

Drugs for Acute Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
3 Antibiotics, Antitubercular Phase 4
4 Amdinocillin Pivoxil Phase 4
5 Analgesics Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Anti-Inflammatory Agents Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Antirheumatic Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Renal Agents Phase 4,Phase 2
14
Cefditoren Approved, Investigational Phase 3 104145-95-1, 117467-28-4 9870843 9571074
15
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
16 Cefditoren pivoxil Phase 3
17 Cephalosporins Phase 3
18 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Topoisomerase Inhibitors Phase 3
21
Nitrofurantoin Approved, Vet_approved Phase 2 67-20-9 5353830
22 Cranberry Approved, Investigational, Nutraceutical Phase 2
23 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
24
Cefixime Approved, Investigational Phase 1 79350-37-1 5362065 54362
25 Orange Approved, Nutraceutical Phase 1
26
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
27
Ceftizoxime Approved, Investigational 68401-81-0 6533629
28
Zinc Approved, Investigational 7440-66-6 32051 23994
29
Fosfomycin Approved 23155-02-4 446987
30
Sulfamethoxazole Approved 723-46-6 5329
31
Trimethoprim Approved, Vet_approved 738-70-5 5578
32
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
33
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
34
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
35
Vitamin C Approved, Nutraceutical 50-81-7 54670067 5785
36 Grape Approved, Nutraceutical
37 Cefpodoxime proxetil
38 Antitubercular Agents
39 Anticoagulants
40 Calcium, Dietary
41 Chelating Agents
42 Vitamins
43 Amoxicillin-Potassium Clavulanate Combination
44 beta-Lactamase Inhibitors
45 Clavulanic Acid
46 Acidophilus Nutraceutical
47 Citrate Nutraceutical
48 Vitamin B2 Nutraceutical

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Management of Urinary Tract Infections in Primary Care Facilities. Completed NCT01132131 Phase 4
2 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
3 Efficacy and Safety of Cefditoren Pivoxil Versus Ciprofloxacin in Acute Uncomplicated Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
4 Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI) Withdrawn NCT01527019 Phase 3 Norfloxacin;Cephalosporins;Cephalosporins
5 Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
6 Short Course Nitrofurantoin for Acute Cystitis Completed NCT00391651 Phase 2 Nitrofurantoin 100mg twice daily x 5 days;TMP/SMX DS twice daily x 3 days
7 A Bioequivalence Study of SKF101804 Cefixime Versus Cefixime Reference Formulation in Healthy Adults Under Fasting Conditions Not yet recruiting NCT03329547 Phase 1 Cefixime test capsule;Cefixime reference capsule
8 Cefpodoxime vs Ciprofloxacin for Acute Cystitis Completed NCT00194532 Cefpodoxime;Ciprofloxacin
9 Assessment of UTI Symptoms and Quality of Life According to Antibiotics Treatment in Acute Uncomplicated Cystitis Completed NCT01631955 Ciprobay
10 Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women Completed NCT03019172
11 Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice Completed NCT00958295
12 Observational Study With Mode of Action-Analysis of Cystorenal Cranberry Extract in Patients With Recurrent Urinary Tract Infections Recruiting NCT03019874
13 Single Dose Monurol for Treatment of Acute Cystitis Active, not recruiting NCT00976963 Fosfomycin;TMP/SMX DS
14 Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women Not yet recruiting NCT03362697 Antibiotics
15 Urell and Pregnancy Terminated NCT01818180

Search NIH Clinical Center for Acute Cystitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Acute Cystitis

Anatomical Context for Acute Cystitis

MalaCards organs/tissues related to Acute Cystitis:

38
Kidney, Testes, Spinal Cord

Publications for Acute Cystitis

Articles related to Acute Cystitis:

(show top 50) (show all 93)
# Title Authors Year
1
External validation study of a clinical decision aid to reduce unnecessary antibiotic prescriptions in women with acute cystitis. ( 28969592 )
2017
2
Less workup, longer treatment, but no clinical benefit observed in women with diabetes and acute cystitis. ( 28544925 )
2017
3
The Acute Cystitis Symptom Score for Patient-Reported Outcome Assessment. ( 27591987 )
2016
4
The efficacy of faropenem for patients with acute cystitis caused byA extended spectrum I^-lactamase producing Escherichia coli. ( 27916471 )
2016
5
Protein-based profiling of the immune response to uropathogenic Escherichia coli in adult patients immediately following hospital admission for acute cystitis. ( 27354295 )
2016
6
Acute cystitis caused by commensal Neisseria oralis: A case report and review of the literature. ( 27889997 )
2016
7
Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary. ( 27020869 )
2016
8
Genotypic Characterization of Virulence Factors in Escherichia coli Isolated from Patients with Acute Cystitis, Pyelonephritis and Asymptomatic Bacteriuria. ( 28208853 )
2016
9
Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. ( 27732661 )
2016
10
Low Concordance With Guidelines for Treatment of Acute Cystitis in Primary Care. ( 26753168 )
2015
11
New self-reporting questionnaire to assess urinary tract infections and differential diagnosis: acute cystitis symptom score. ( 24457349 )
2014
12
Role of special pathogenicity versus prevalence theory in pathogenesis of acute cystitis caused by Escherichia coli. ( 24899598 )
2014
13
An unusual case of acute cystitis associated with mixed flora in voided urine in an adult male. ( 24153123 )
2014
14
Re: voided midstream urine culture and acute cystitis in premenopausal women. ( 24745498 )
2014
15
Voided midstream urine culture is a good test for acute cystitis in premenopausal women. ( 24591543 )
2014
16
Outcome of nonadherence to antimicrobial treatment guidelines in ambulatory patients with acute cystitis: a nationwide population-based study. ( 25175125 )
2014
17
Antibiotic-resistant Escherichia coli in women with acute cystitis in Canada. ( 24421825 )
2013
18
Treatment of acute cystitis in Hungary: comparison with national guidelines and with disease-specific quality indicators. ( 23547569 )
2013
19
Risk factors for recurrent cystitis following acute cystitis in female patients. ( 23380970 )
2013
20
Voided midstream urine culture and acute cystitis in premenopausal women. ( 24224622 )
2013
21
Genotypic characteristics and biofilm formation among Escherichia coli isolates from Indian women with acute cystitis. ( 23296752 )
2013
22
Treating acute cystitis with biodegradable micelle-encapsulated quercetin. ( 22661886 )
2012
23
Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire? ( 22023989 )
2012
24
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? ( 23030327 )
2012
25
Urinary MMP-9/NGAL complex in children with acute cystitis. ( 21556719 )
2011
26
Overestimation error and unnecessary antibiotic prescriptions for acute cystitis in adult women. ( 21191120 )
2011
27
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. ( 18991182 )
2009
28
Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria. ( 19247873 )
2009
29
Relationship between Escherichia coli strains causing acute cystitis in women and the fecal E. coli population of the host. ( 18495863 )
2008
30
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. ( 18036139 )
2008
31
Multidrug-resistant Escherichia fergusonii: a case of acute cystitis. ( 18256229 )
2008
32
Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. ( 18060746 )
2008
33
Validation of a decision aid to assist physicians in reducing unnecessary antibiotic drug use for acute cystitis. ( 17998492 )
2007
34
Acute cystitis in women: experience with a telephone-based algorithm. ( 17970014 )
2007
35
Sharing of virulent Escherichia coli clones among household members of a woman with acute cystitis. ( 17051483 )
2006
36
Choice of antibiotic for empirical therapy of acute cystitis in a setting of high antimicrobial resistance. ( 16505574 )
2006
37
Outcomes of a pharmacoepidemiological survey on the antibiotic treatment of uncomplicated acute cystitis in community. ( 16330217 )
2006
38
Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women. ( 16333100 )
2005
39
Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran. ( 15845429 )
2005
40
Women's quality of life is decreased by acute cystitis and antibiotic adverse effects associated with treatment. ( 16048650 )
2005
41
A 'gap' between physician and patient assessment of symptom severity in acute cystitis?: a multicenter trial of women treated with extended-release ciprofloxacin. ( 19667683 )
2004
42
Managing acute cystitis in women. ( 15020396 )
2004
43
Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women. ( 12604518 )
2003
44
Managing acute cystitis in women--are we mistreating? ( 12876128 )
2003
45
Empirical treatment of acute cystitis in women. ( 12842322 )
2003
46
Antibiotic treatment for five days is effective in children with acute cystitis. ( 12641137 )
2003
47
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 12356077 )
2002
48
Antibiotic treatment for five days is effective in children with acute cystitis. ( 11883819 )
2002
49
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 11871930 )
2002
50
Escherichia coli O18:K1:H7 isolates from patients with acute cystitis and neonatal meningitis exhibit common phylogenetic origins and virulence factor profiles. ( 11133374 )
2001

Variations for Acute Cystitis

Expression for Acute Cystitis

Search GEO for disease gene expression data for Acute Cystitis.

Pathways for Acute Cystitis

Pathways related to Acute Cystitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 CCL2 CXCL1 CXCL8 IL18 IL6 MCU
2
Show member pathways
12.44 CCL2 CXCL1 IL18 IL6
3
Show member pathways
12.18 ALB CCL2 CRP IL6
4
Show member pathways
12.17 CCL2 CXCL1 CXCL8 IL6
5
Show member pathways
12 CXCL8 IL18 IL6
6
Show member pathways
11.85 CCL2 CXCL1 CXCL8
7 11.84 CCL2 CXCL1 CXCL8 IL6
8 11.81 CCL2 CXCL1 IL6
9 11.79 CXCL1 CXCL8 IL6
10 11.79 CCL2 CXCL8 IL18 IL6
11 11.76 CCL2 CXCL8 IL6
12 11.73 CXCL1 CXCL8 IL6
13
Show member pathways
11.71 CXCL1 CXCL8 IL6
14 11.64 CXCL1 CXCL8 IL18 IL6
15 11.5 CCL2 CXCL8 IL6
16 11.37 CCL2 IL18 KLK3
17 11.31 CCL2 CXCL1 CXCL8 IL18 IL6
18 11.3 CXCL1 CXCL8 IL18 IL6
19 11.18 CCL2 CXCL8 IL6
20 11.15 CCL2 CXCL8 IL18 IL6
21 10.95 CCL2 CXCL1 CXCL8 IL18 IL6
22 10.86 CCL2 CXCL1 CXCL8 IL18 IL6
23 10.82 CRP CXCL8 IL6
24 10.71 CCL2 CXCL1 CXCL8 IL18 IL6

GO Terms for Acute Cystitis

Cellular components related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ALB CCL2 CRP CXCL1 CXCL8 IL18

Biological processes related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.61 CCL2 CXCL8 IL6
2 immune response GO:0006955 9.55 CCL2 CXCL1 CXCL8 IL18 IL6
3 chemokine-mediated signaling pathway GO:0070098 9.43 CCL2 CXCL1 CXCL8
4 PERK-mediated unfolded protein response GO:0036499 9.4 CCL2 CXCL8
5 neutrophil activation GO:0042119 9.37 CXCL8 IL18
6 regulation of receptor activity GO:0010469 9.35 CCL2 CXCL1 CXCL8 IL18 IL6
7 negative regulation of lipid storage GO:0010888 9.32 CRP IL6
8 inflammatory response GO:0006954 9.1 CCL2 CRP CXCL1 CXCL8 IL18 IL6

Molecular functions related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CCL2 CXCL1 CXCL8
2 cytokine activity GO:0005125 9.02 CCL2 CXCL1 CXCL8 IL18 IL6

Sources for Acute Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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