Aliases & Classifications for Acute Cystitis

MalaCards integrated aliases for Acute Cystitis:

Name: Acute Cystitis 12 14 69
Urinary Tract Infection 12 69
Recurrent Urinary Tract Infection 69
Urinary Tract Infections 41

Classifications:



External Ids:

Disease Ontology 12 DOID:13148
ICD10 33 N30.0 N39.0
ICD9CM 35 595.0
NCIt 47 C26934
UMLS 69 C0149523

Summaries for Acute Cystitis

MedlinePlus : 41 the urinary system is the body's drainage system for removing wastes and extra water. it includes two kidneys, two ureters, a bladder, and a urethra. urinary tract infections (utis) are the second most common type of infection in the body. you may have a uti if you notice pain or burning when you urinate fever, tiredness, or shakiness an urge to urinate often pressure in your lower belly urine that smells bad or looks cloudy or reddish pain in your back or side below the ribs people of any age or sex can get utis. but about four times as many women get utis as men. you're also at higher risk if you have diabetes, need a tube to drain your bladder, or have a spinal cord injury. if you think you have a uti it is important to see your doctor. your doctor can tell if you have a uti with a urine test. treatment is with antibiotics. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Acute Cystitis, also known as urinary tract infection, is related to neonatal urinary tract infectious disease and urethral syndrome, and has symptoms including fever, pruritus and uti symptoms. An important gene associated with Acute Cystitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Immune response IL-23 signaling pathway. The drugs Ketorolac and Nitrofurantoin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord.

Disease Ontology : 12 A cystitis characterized by a sudden onset or severe symptoms.

Wikipedia : 72 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Acute Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Acute Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 neonatal urinary tract infectious disease 11.4
2 urethral syndrome 11.2
3 collagenopathy type 2 alpha 1 10.8 CRP IL6
4 crystal arthropathies 10.8 CRP IL6
5 shoulder impingement syndrome 10.8 CRP IL6
6 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
7 mental retardation, autosomal dominant 32 10.7 CCL2 CXCL1
8 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.7 CCL2 IL18 IL6
9 x-linked dominant intellectual disability-epilepsy syndrome 10.7 CRP IL18 IL6
10 islet cell tumor 10.7 CCL2 CRP IL6
11 benign neonatal seizures 10.7 CRP IL18 IL6
12 antigen-peptide-transporter 2 deficiency 10.7 CCL2 IL6
13 oculomotor nerve paralysis 10.7 CXCL8 IL6
14 focal dystonia 10.7 CCL2 CRP IL6
15 cytomegalovirus retinitis 10.6 CCL2 CXCL8
16 common peroneal nerve lesion 10.6 CXCL8 IL6
17 epstein-barr virus hepatitis 10.6 CRP IL6
18 dermatitis herpetiformis, familial 10.6 CCL2 CRP IL6
19 neonatal jaundice 10.6 CCL2 IL18 IL6
20 nephrogenic systemic fibrosis 10.6 ADCY10 SLC5A5
21 inherited metabolic disorder 10.6 CCL2 CRP IL6
22 drug rash with eosinophilia and systemic symptoms 10.6 CXCL8 IL6
23 pancreatic acth hormone producing tumor 10.6 CCL2 CRP IL6
24 spirillary rat-bite fever 10.6 CXCL8 IL6
25 flinders island spotted fever 10.6 CCL2 CXCL8
26 kaposi sarcoma 10.5 CRP IL18 IL6
27 small cell lung cancer, adult 10.5 CRP CXCL8
28 schwannoma of ureter 10.5 CCL2 CXCL8 IL6
29 myofascial pain syndrome 10.5 CCL2 CXCL8 IL6
30 orthostatic proteinuria 10.5 CXCL8 IL18 IL6
31 ovarian mucinous adenofibroma 10.5 CCL2 CXCL8 IL6
32 cystitis 10.5
33 hyperlipoproteinemia type iv 10.5 ALB CRP IL6
34 esophagus leiomyoma 10.5 CXCL8 IL18 IL6
35 steatorrhea 10.5 CCL2 CXCL8 IL18
36 plummer's disease 10.5 ALB CRP IL6
37 krukenberg carcinoma 10.5 KLK3 MCU
38 erythema elevatum diutinum 10.5 CRP IL6
39 ischemic heart disease 10.5 ALB CRP IL6
40 melorheostosis 10.5 ALB CRP IL6
41 rift valley fever 10.5 ALB CRP IL6
42 asbestosis 10.5 CCL2 CXCL8 IL6
43 cicatricial lagophthalmos 10.5 CRP CXCL8 IL6
44 psychotic disorder 10.5 CXCL8 IL6
45 myeloid sarcoma 10.5 CRP CXCL8 IL6
46 opportunistic bacterial infectious disease 10.5 ALB CRP IL6
47 spastic entropion 10.5 ALB CRP IER3IP1
48 breast disease 10.5 CRP CXCL8 IL6
49 bardet-biedl syndrome 8 10.5 CRP CXCL8 IL6
50 louping ill 10.5 CCL2 CRP CXCL8

Comorbidity relations with Acute Cystitis via Phenotypic Disease Network (PDN): (show top 50) (show all 438)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Anterolateral Myocardial Infarction
Acute Conjunctivitis Acute Cor Pulmonale
Acute Kidney Failure Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Sphenoidal Sinusitis Adjustment Disorder
Adrenal Gland Disease Agammaglobulinemia, X-Linked 1
Alcohol Abuse Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Algoneurodystrophy Allergic Urticaria
Alopecia, Neurologic Defects, and Endocrinopathy Syndrome Alzheimer Disease
Amnestic Disorder Amyloidosis
Amyotrophic Lateral Sclerosis 1 Anorexia Nervosa
Anus Cancer Anxiety Disorder
Aortic Aneurysm Aortic Atherosclerosis
Aplastic Anemia Asthma
Asthma Susceptibility, Phf11-Related Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autoimmune Hemolytic Anemia Autonomic Nervous System Disease
Bacteremia Bacterial Meningitis
Balanoposthitis Basilar Artery Insufficiency
Benign Essential Hypertension Benign Hypertensive Renal Disease
Biliary Tract Disease Bipolar Disorder
Bladder Disease Bladder Neck Obstruction
Bleeding Disorder, Platelet-Type, 11 Blepharitis

Graphical network of the top 20 diseases related to Acute Cystitis:



Diseases related to Acute Cystitis

Symptoms & Phenotypes for Acute Cystitis

UMLS symptoms related to Acute Cystitis:


fever, pruritus, uti symptoms

Drugs & Therapeutics for Acute Cystitis

Drugs for Acute Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 2 67-20-9 5353830
3
Fosfomycin Approved Phase 4 23155-02-4 446987
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
5 Antibiotics, Antitubercular Phase 4
6 Analgesics Phase 4,Phase 1
7 Analgesics, Non-Narcotic Phase 4,Phase 1
8 Anti-Inflammatory Agents Phase 4,Phase 1
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1
10 Antirheumatic Agents Phase 4,Phase 1
11 Cyclooxygenase Inhibitors Phase 4,Phase 1
12 Ketorolac Tromethamine Phase 4
13 Peripheral Nervous System Agents Phase 4,Phase 1
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Renal Agents Phase 4,Phase 2,Phase 1
16
Cefditoren Approved Phase 3 117467-28-4, 104145-95-1 9571074 9870843
17
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
18 Cefditoren pivoxil Phase 3
19 Cephalosporins Phase 3
20 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Topoisomerase Inhibitors Phase 3
23 Cranberry Approved, Nutraceutical Phase 2
24 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
25
Ibuprofen Approved Phase 1 15687-27-1 3672
26 Amdinocillin Pivoxil Phase 1
27
Cefpodoxime Approved, Vet_approved 82619-04-3, 80210-62-4 6335986
28
Ceftizoxime Approved 68401-81-0 6533629
29
Celecoxib Approved, Investigational 169590-42-5 2662
30
Sulfamethoxazole Approved 723-46-6 5329
31
Trimethoprim Approved, Vet_approved 738-70-5 5578
32
Zinc Approved 7440-66-6 32051 23994
33
Riboflavin Approved, Nutraceutical, Vet_approved 83-88-5 493570
34
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
35 Cefpodoxime proxetil
36 Antitubercular Agents
37 Cyclooxygenase 2 Inhibitors
38 Mitogens
39 Vitamins
40 Anticoagulants
41 Calcium, Dietary
42 Chelating Agents
43 Vitamin B2 Nutraceutical
44 Anthocyanidin Nutraceutical
45 Citrate Nutraceutical
46
Citric Acid Nutraceutical, Vet_approved 77-92-9 311
47 Lingonberry Nutraceutical
48 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 Management of Urinary Tract Infections in Primary Care Facilities. Completed NCT01132131 Phase 4
2 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
3 Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women Active, not recruiting NCT01966653 Phase 4 nitrofurantoin;fosfomycin
4 Efficacy and Safety of Cefditoren Pivoxil Versus Ciprofloxacin in Acute Uncomplicated Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
5 Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI) Withdrawn NCT01527019 Phase 3 Norfloxacin;Cephalosporins;Cephalosporins
6 Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
7 Short Course Nitrofurantoin for Acute Cystitis Completed NCT00391651 Phase 2 Nitrofurantoin 100mg twice daily x 5 days;TMP/SMX DS twice daily x 3 days
8 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 1 Ibuprofen;Mecillinam
9 Cefpodoxime vs Ciprofloxacin for Acute Cystitis Completed NCT00194532 Cefpodoxime;Ciprofloxacin
10 Assessment of UTI Symptoms and Quality of Life According to Antibiotics Treatment in Acute Uncomplicated Cystitis Completed NCT01631955 Ciprobay
11 Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice Completed NCT00958295
12 Urinary NGF as A Biomarker for Acute Bacterial Cystitis Completed NCT01800799 Baktar 800mg h.s.;Celecoxib 200mg QD
13 Observational Study With Mode of Action-Analysis of Cystorenal Cranberry Extract in Patients With Recurrent Urinary Tract Infections Recruiting NCT03019874
14 Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in Children Recruiting NCT01861353
15 Single Dose Monurol for Treatment of Acute Cystitis Active, not recruiting NCT00976963 Fosfomycin;TMP/SMX DS
16 Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women Not yet recruiting NCT03019172
17 Prophylactic Use of Cranberries in Recurrent Bacterial Cystitis in Women Not yet recruiting NCT03032003
18 Urell and Pregnancy Terminated NCT01818180

Search NIH Clinical Center for Acute Cystitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acute Cystitis

Anatomical Context for Acute Cystitis

MalaCards organs/tissues related to Acute Cystitis:

39
Kidney, Testes, Spinal Cord

Publications for Acute Cystitis

Articles related to Acute Cystitis:

(show top 50) (show all 92)
id Title Authors Year
1
Less workup, longer treatment, but no clinical benefit observed in women with diabetes and acute cystitis. ( 28544925 )
2017
2
Genotypic Characterization of Virulence Factors in Escherichia coli Isolated from Patients with Acute Cystitis, Pyelonephritis and Asymptomatic Bacteriuria. ( 28208853 )
2016
3
The efficacy of faropenem for patients with acute cystitis caused byA extended spectrum I^-lactamase producing Escherichia coli. ( 27916471 )
2016
4
Protein-based profiling of the immune response to uropathogenic Escherichia coli in adult patients immediately following hospital admission for acute cystitis. ( 27354295 )
2016
5
The Acute Cystitis Symptom Score for Patient-Reported Outcome Assessment. ( 27591987 )
2016
6
Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. ( 27732661 )
2016
7
Acute cystitis caused by commensal Neisseria oralis: A case report and review of the literature. ( 27889997 )
2016
8
Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary. ( 27020869 )
2016
9
Low Concordance With Guidelines for Treatment of Acute Cystitis in Primary Care. ( 26753168 )
2015
10
Role of special pathogenicity versus prevalence theory in pathogenesis of acute cystitis caused by Escherichia coli. ( 24899598 )
2014
11
An unusual case of acute cystitis associated with mixed flora in voided urine in an adult male. ( 24153123 )
2014
12
Outcome of nonadherence to antimicrobial treatment guidelines in ambulatory patients with acute cystitis: a nationwide population-based study. ( 25175125 )
2014
13
New self-reporting questionnaire to assess urinary tract infections and differential diagnosis: acute cystitis symptom score. ( 24457349 )
2014
14
Voided midstream urine culture is a good test for acute cystitis in premenopausal women. ( 24591543 )
2014
15
Re: voided midstream urine culture and acute cystitis in premenopausal women. ( 24745498 )
2014
16
Risk factors for recurrent cystitis following acute cystitis in female patients. ( 23380970 )
2013
17
Treatment of acute cystitis in Hungary: comparison with national guidelines and with disease-specific quality indicators. ( 23547569 )
2013
18
Voided midstream urine culture and acute cystitis in premenopausal women. ( 24224622 )
2013
19
Antibiotic-resistant Escherichia coli in women with acute cystitis in Canada. ( 24421825 )
2013
20
Genotypic characteristics and biofilm formation among Escherichia coli isolates from Indian women with acute cystitis. ( 23296752 )
2013
21
Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire? ( 22023989 )
2012
22
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? ( 23030327 )
2012
23
Treating acute cystitis with biodegradable micelle-encapsulated quercetin. ( 22661886 )
2012
24
Overestimation error and unnecessary antibiotic prescriptions for acute cystitis in adult women. ( 21191120 )
2011
25
Urinary MMP-9/NGAL complex in children with acute cystitis. ( 21556719 )
2011
26
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. ( 18991182 )
2009
27
Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria. ( 19247873 )
2009
28
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. ( 18036139 )
2008
29
Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. ( 18060746 )
2008
30
Multidrug-resistant Escherichia fergusonii: a case of acute cystitis. ( 18256229 )
2008
31
Relationship between Escherichia coli strains causing acute cystitis in women and the fecal E. coli population of the host. ( 18495863 )
2008
32
Validation of a decision aid to assist physicians in reducing unnecessary antibiotic drug use for acute cystitis. ( 17998492 )
2007
33
Acute cystitis in women: experience with a telephone-based algorithm. ( 17970014 )
2007
34
Sharing of virulent Escherichia coli clones among household members of a woman with acute cystitis. ( 17051483 )
2006
35
Outcomes of a pharmacoepidemiological survey on the antibiotic treatment of uncomplicated acute cystitis in community. ( 16330217 )
2006
36
Choice of antibiotic for empirical therapy of acute cystitis in a setting of high antimicrobial resistance. ( 16505574 )
2006
37
Women's quality of life is decreased by acute cystitis and antibiotic adverse effects associated with treatment. ( 16048650 )
2005
38
Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran. ( 15845429 )
2005
39
Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women. ( 16333100 )
2005
40
A 'gap' between physician and patient assessment of symptom severity in acute cystitis?: a multicenter trial of women treated with extended-release ciprofloxacin. ( 19667683 )
2004
41
Managing acute cystitis in women. ( 15020396 )
2004
42
Managing acute cystitis in women--are we mistreating? ( 12876128 )
2003
43
Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women. ( 12604518 )
2003
44
Antibiotic treatment for five days is effective in children with acute cystitis. ( 12641137 )
2003
45
Empirical treatment of acute cystitis in women. ( 12842322 )
2003
46
Antibiotic treatment for five days is effective in children with acute cystitis. ( 11883819 )
2002
47
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 11871930 )
2002
48
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 12356077 )
2002
49
Escherichia coli O18:K1:H7 isolates from patients with acute cystitis and neonatal meningitis exhibit common phylogenetic origins and virulence factor profiles. ( 11133374 )
2001
50
'Telephone treatment' of uncomplicated acute cystitis. ( 10486997 )
1999

Variations for Acute Cystitis

Expression for Acute Cystitis

Search GEO for disease gene expression data for Acute Cystitis.

Pathways for Acute Cystitis

Pathways related to Acute Cystitis according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 CCL2 CXCL1 CXCL8 IL18 IL6 MCU
2
Show member pathways
12.43 CCL2 CXCL1 IL18 IL6
3
Show member pathways
12.17 CCL2 CXCL1 CXCL8 IL6
4
Show member pathways
11.86 CCL2 CXCL1 CXCL8
5 11.84 CCL2 CXCL1 CXCL8 IL6
6 11.79 CCL2 CXCL1 IL6
7 11.79 CCL2 CXCL8 IL18 IL6
8 11.78 CXCL1 CXCL8 IL6
9 11.74 CCL2 CXCL8 IL6
10 11.72 CXCL1 CXCL8 IL6
11
Show member pathways
11.69 CXCL1 CXCL8 IL6
12 11.64 CXCL1 CXCL8 IL18 IL6
13 11.5 CCL2 CXCL8 IL6
14 11.37 CCL2 IL18 KLK3
15 11.31 CCL2 CXCL1 CXCL8 IL18 IL6
16 11.3 CXCL1 CXCL8 IL18 IL6
17 11.18 CCL2 CXCL8 IL6
18 11.15 CCL2 CXCL8 IL18 IL6
19 10.95 CCL2 CXCL1 CXCL8 IL18 IL6
20 10.82 CRP CXCL8 IL6
21 10.71 CCL2 CXCL1 CXCL8 IL18 IL6

GO Terms for Acute Cystitis

Cellular components related to Acute Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ALB CCL2 CRP CXCL1 CXCL8 IL18

Biological processes related to Acute Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 CCL2 CXCL1 CXCL8 IL18 IL6
2 cellular response to tumor necrosis factor GO:0071356 9.63 CCL2 CXCL8 IL6
3 cellular response to interleukin-1 GO:0071347 9.58 CCL2 CXCL8 IL6
4 PERK-mediated unfolded protein response GO:0036499 9.43 CCL2 CXCL8
5 chemokine-mediated signaling pathway GO:0070098 9.43 CCL2 CXCL1 CXCL8
6 negative regulation of lipid storage GO:0010888 9.32 CRP IL6
7 positive regulation of T-helper 2 cell differentiation GO:0045630 9.16 IL18 IL6
8 inflammatory response GO:0006954 9.1 CCL2 CRP CXCL1 CXCL8 IL18 IL6
9 regulation of vascular endothelial growth factor production GO:0010574 8.96 CCL2 IL6

Molecular functions related to Acute Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CCL2 CXCL1 CXCL8
2 cytokine activity GO:0005125 9.02 CCL2 CXCL1 CXCL8 IL18 IL6

Sources for Acute Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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