MCID: ACT004
MIFTS: 43

Acute Diarrhea malady

Genetic diseases, Gastrointestinal diseases, Rare diseases categories

Summaries for Acute Diarrhea

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

MalaCards: Acute Diarrhea is related to diarrhea and hepatitis. An important gene associated with Acute Diarrhea is PITX1 (paired-like homeodomain 1), and among its related pathways are Selected targets of ESR1 and Selected targets of C EBPalpha. The compounds toluene diisocyanate and heroin have been mentioned in the context of this disorder. Affiliated tissues include breast, small intestine and t cells, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Acute Diarrhea

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

acute diarrhea 9 11 63


External Ids:

Disease Ontology9 DOID:0050140

Related Diseases for Acute Diarrhea

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity family:

Inflammatory Diarrhea acute diarrhea
Diarrhea Diarrhea 7

Diseases related to Acute Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea32.0LTF, ALB
2hepatitis30.2ALB, LTF
3malaria30.0G6PD, ALB
4primary biliary cirrhosis29.9ALB, LTF
5blindness10.6
6cholera10.3
7cryptosporidiosis10.1
8shigellosis10.1
9influenza10.1
10agammaglobulinemia, x-linked 110.1
11cholangitis10.1ALB
12eosinophilic gastroenteritis10.1IGHE
13strongyloidiasis10.1IGHE
14bronchiolitis10.1IGHE
15membranous glomerulonephritis10.0ALB, MME
16kernicterus10.0ALB, G6PD
17bilirubin metabolic disorder10.0G6PD, ALB
18iron deficiency anemia10.0LTF, G6PD
19acute kidney failure10.0ALB, G6PD
20mastitis10.0LTF, ALB
21amyloid tumor10.0MME, LTF
22amyloidosis10.0ALB, MME
23asthma10.0IGHE, MME
24ulcerative colitis10.0LTF, ALB
25crohn's disease10.0LTF, ALB
26angioedema10.0IGHE, MME
27essential hypertension10.0ALB, MME
28respiratory failure10.0G6PD, IGHE
29vasculitis10.0LTF, ALB
30rhinitis10.0IGHE, ALB
31primary hyperoxaluria10.0ALB, MME, G6PD
32otitis media10.0LTF, IGHE
33deficiency anemia10.0G6PD, MME, ALB
34viral infectious disease10.0PITX1, G6PD, MME
35bronchitis10.0LTF, IGHE
36hypersensitivity reaction type ii disease10.0LTF, ALB
37galactosemia10.0G6PD, MME, ALB
38pancreatitis10.0ALB, LTF
39cystic fibrosis10.0LTF, ALB, MME
40glomerulonephritis10.0ALB, MME
41bloom syndrome10.0
42rift valley fever10.0
43reticular dysgenesis10.0
44good syndrome10.0
45lassa fever10.0
46acute urate nephropathy10.0
47appendicitis10.0
48hypoglycemia10.0
49autoimmune hepatitis10.0
50yellow fever10.0

Graphical network of the top 20 diseases related to Acute Diarrhea:



Diseases related to acute diarrhea

Symptoms for Acute Diarrhea

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Drugs & Therapeutics for Acute Diarrhea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Diarrhea

Drug clinical trials:

Search ClinicalTrials for Acute Diarrhea

Search NIH Clinical Center for Acute Diarrhea

Search CenterWatch for Acute Diarrhea

Genetic Tests for Acute Diarrhea

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Anatomical Context for Acute Diarrhea

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Sources:
34MalaCards
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MalaCards organs/tissues related to Acute Diarrhea:

34
Breast, Small intestine, T cells, Appendix

Animal Models for Acute Diarrhea or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Acute Diarrhea:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9LTF, ALB, MME, G6PD, IGHE

Publications for Acute Diarrhea

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Sources:
53PubMed
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Articles related to Acute Diarrhea:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Therapeutic zinc and copper supplementation in acute diarrhea does not influence short-term morbidity and growth: double-blind randomized controlled trial. (22926212)
2013
2
Enteroaggregative Escherichia coli and acute diarrhea in children: a meta-analysis of South Asian populations. (23179250)
2013
3
Potential impact of influenza A/H1N1 pandemic and hand-gels on acute diarrhea epidemic in France. (24124479)
2013
4
Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus. (22855485)
2012
5
Acute diarrhea among military recruits. (23214210)
2012
6
Molecular characterization of Salmonella strains in individuals with acute diarrhea syndrome in the State of Sucre, Venezuela. (22760131)
2012
7
Acute diarrhea in hospitalized children of the municipality of Juiz de Fora, MG, Brazil: prevalence and risk factors associated with disease severity. (23329220)
2012
8
Etiology of acute diarrhea due to enteropathogenic bacteria in Beijing, China. (22546618)
2012
9
A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the Multinational Force and Observers, Sinai, Egypt. (21212203)
2011
10
Seasonal variation of enteropathogens in infants and preschoolers with acute diarrhea in western Mexico. (20706147)
2010
11
Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. (19416499)
2009
12
Acute diarrhea in hospitalized horses. (19580946)
2009
13
Advances in defining etiology and new therapeutic approaches in acute diarrhea. (17825422)
2007
14
Acute diarrhea in the adult horse: case example and review. (16627106)
2006
15
Cytotoxicity and antimicrobial susceptibility of Clostridium difficile isolated from hospitalized children with acute diarrhea. (16701515)
2004
16
Epidemiologic and clinical characteristics of acute diarrhea with emphasis on Entamoeba histolytica infections in preschool children in an urban slum of Dhaka, Bangladesh. (14640500)
2003
17
Acute diarrhea in frail elderly nursing home patients. (12807595)
2003
18
Detection, subgroup specificity, and genotype diversity of rotavirus strains in children with acute diarrhea in Paraguay. (11980947)
2002
19
A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. (12385443)
2002
20
Spectrum of vibrio species associated with acute diarrhea in North Jakarta, Indonesia. (12088614)
2002
21
Surveillance of bacterial pathogens associated with acute diarrhea in Lima, Peru. (10737846)
2000
22
Can malabsorbed carbohydrates be useful in the treatment of acute diarrhea? (11144433)
2000
23
Molecular Epidemiology of Group A Rotavirus Causing Acute Diarrhea in Infants and Young Children in Rio de Janeiro, Brazil, 1997-1998. (11096435)
1999
24
Acute diarrhea: a practical review. (10378626)
1999
25
Use of undiluted whole cow's milk is effective for the routine treatment of children with acute diarrhea and severe dehydration. (9814379)
1998
26
Dietary management of acute diarrhea with local foods in a Guatemalan rural community. (9401505)
1997
27
Evaluation of a simplified HEp-2 cell adherence assay for Escherichia coli isolated from south Indian children with acute diarrhea and controls. (7559981)
1995
28
Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children. (8586781)
1995
29
New developments in acute diarrhea. (8055704)
1994
30
Two-year study of endemic enteric pathogens associated with acute diarrhea in New Caledonia. (8077399)
1994
31
Control randomized study of rehydration/rehydration with dioctahedral smectite in ambulatory Thai infants with acute diarrhea. (7825006)
1994
32
Loperamide oxide in the treatment of acute diarrhea in adults. (7697694)
1994
33
Earth, wind, and fiber: is there a drug to treat acute diarrhea? (7815252)
1994
34
The management of acute diarrhea in children: oral rehydration, maintenance, and nutritional therapy. Centers for Disease Control and Prevention. (1435668)
1992
35
Effect of diosmectite on intestinal permeability changes in acute diarrhea: a double-blind placebo-controlled trial. (1517944)
1992
36
Comparison of glucose/electrolyte and maltodextrin/glycine/glycyl-glycine/electrolyte oral rehydration solutions in acute diarrhea in children. (1779314)
1991
37
Enterotoxins and adhesins of enterotoxigenic Escherichia coli: are they risk factors for acute diarrhea in the community? (1973696)
1990
38
Acute diarrhea in children. (2664748)
1989
39
Enteropathogenic serotypes of E. coli in acute diarrhea in Ajmer. (3068136)
1988
40
Detection of enterotoxigenic strains of Escherichia coli in children with acute diarrhea. (3334593)
1987
41
A two-year longitudinal study on the etiology of acute diarrhea in young children in Northern Italy. (2983179)
1985
42
The evaluation and management of acute diarrhea. (6730484)
1984
43
Etiological agents responsible for acute diarrhea in children in an urban community in Burma. (6226849)
1983
44
Nonenteric sources of rotavirus in acute diarrhea. (6273477)
1981
45
Maternal beliefs regarding diet during acute diarrhea. (7327655)
1981
46
Acute diarrhea on an Apache Indian reservation. (4594476)
1974
47
The participation of lactic acid in disturbances of the acid-base balance in acute diarrhea in infants. (5370557)
1969
48
Hypoglycemia in neonatal calves associated with acute diarrhea. (5655836)
1968
49
Spectrum of acute diarrhea in a general hospital. 4. "Antibiotic bowel" and pseudomembranous enterocolitis. (5827657)
1965
50
Spectrum of acute diarrhea in general hospitals. 5. Conclusion. (5827658)
1965

Variations for Acute Diarrhea

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Expression for genes affiliated with Acute Diarrhea

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Diarrhea

Search GEO for disease gene expression data for Acute Diarrhea.

Pathways for genes affiliated with Acute Diarrhea

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Sources:
51PathCards, 13EMD Millipore
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Pathways related to Acute Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LTF, MME
29.3LTF, ALB

Compounds for genes affiliated with Acute Diarrhea

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Acute Diarrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1toluene diisocyanate469.9MME, IGHE
2heroin46 52 1211.8IGHE, MME
3periodate469.8LTF, IGHE
4sulfisoxazole46 52 62 1212.8ALB, G6PD
5fosinopril46 1210.8ALB, MME
6cefazolin46 1210.8ALB, G6PD
7ciprofloxacin46 52 1211.8LTF, G6PD
8lisinopril46 52 25 1212.8ALB, MME
9hhpa469.8ALB, IGHE
10bismuth46 2510.7LTF, ALB
11ceftriaxone46 1210.7ALB, G6PD
12iohexol469.7LTF, ALB
13enalapril46 52 1211.7MME, ALB
14sucralfate46 1210.7IGHE, ALB
15leupeptin469.7LTF, MME
16ampicillin46 1210.7LTF, ALB
17budesonide46 52 1211.7LTF, IGHE
18cellulose acetate469.7G6PD, ALB
19furosemide46 62 30 52 25 1214.6MME, ALB
20glutaraldehyde469.6G6PD, ALB
21mycophenolic acid46 52 1211.6ALB, IGHE
22propofol46 52 1211.5ALB, IGHE
23probenecid30 46 62 52 1213.5G6PD, ALB
24methacholine46 52 1211.5LTF, IGHE, MME
25capsaicin46 3010.5IGHE, LTF, MME
26captopril46 62 52 30 1213.4ALB, MME
27naloxone46 30 52 1212.4MME, ALB
28aprotinin46 1210.4LTF, MME, IGHE
29pertussis469.3IGHE, LTF
30cyclophosphamide46 52 1211.3LTF, G6PD, IGHE
31sulfamethoxazole52 46 1211.3G6PD, IGHE, ALB
32vitamin b12469.3G6PD, ALB, LTF
33n acetylcysteine469.3IGHE, G6PD, LTF
34mannitol46 1210.3G6PD, ALB, IGHE
35thyroxine46 2510.2ALB, IGHE, G6PD
36folate469.2G6PD, ALB, IGHE
37cyclosporin a46 30 6211.1IGHE, MME, LTF
38actinomycin d469.0LTF, MME, G6PD, IGHE
39adenylate469.0IGHE, G6PD, MME, LTF
40citrate468.9G6PD, LTF, MME, ALB
41lactate468.9ALB, IGHE, G6PD, MME
42estrogen468.9LTF, G6PD, IGHE, MME
43vitamin a46 25 1210.8MME, ALB, LTF, IGHE
44testosterone46 62 25 1211.8MME, G6PD, IGHE, ALB
45indomethacin46 30 62 1211.8IGHE, MME, ALB, LTF
46histamine46 30 2510.8LTF, ALB, MME, IGHE
47aspartate468.8LTF, IGHE, ALB, G6PD
48glutamine468.7IGHE, LTF, G6PD
49ascorbic acid46 259.4LTF, MME, ALB, IGHE, G6PD
50creatinine468.4MME, IGHE, G6PD, ALB, LTF

GO Terms for genes affiliated with Acute Diarrhea

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Sources:
17Gene Ontology
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Cellular components related to Acute Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.5LTF, ALB, MME, G6PD

Biological processes related to Acute Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.2MME, PYGO1
2retina homeostasisGO:0018959.0LTF, ALB

Products for genes affiliated with Acute Diarrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Diarrhea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet