Acute Diarrhea malady

Disease Ontology: A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.⁶

MalaCards: Acute Diarrhea is related to diarrhea and blindness. An important gene associated with Acute Diarrhea is PITX1 (paired-like homeodomain 1), and among its related pathways are Selected targets of ESR1 and Selected targets of C/EBPalpha. The compounds fosinopril and bismuth have been mentioned in the context of this disorder. Affiliated tissues include breast.

acute diarrhea 6 8 43

Diseases related to acute diarrhea by text searches and GeneDecks gene sharing:

(show top 50)    (show all 107)

id	Related Disease	Score	Top Affiliating Genes
1	diarrhea	28.2	G6PD, LTF, PITX1, PYGO1, ALB, IGHE
2	blindness	25.3	G6PD, LTF, ALB, IGHE, MME
3	parotitis	13.0	G6PD, LTF
4	bilirubin metabolic disorder	13.0	ALB, G6PD
5	kernicterus	13.0	G6PD, ALB
6	senile cataract	13.0	G6PD, ALB
7	orthostatic hypotension	13.0	G6PD, ALB
8	hydrops fetalis	12.9	G6PD, ALB
9	chronic kidney failure	12.9	ALB, LTF
10	paracoccidioidomycosis	12.9	G6PD, ALB
11	diabetic ketoacidosis	12.9	G6PD, ALB
12	neonatal jaundice	12.9	ALB, G6PD
13	protein-energy malnutrition	12.9	LTF, ALB
14	crigler-najjar syndrome	12.8	ALB, G6PD
15	homocystinuria	12.8	ALB, G6PD
16	rheumatic fever	12.8	G6PD, ALB
17	congenital hypothyroidism	12.8	G6PD, ALB
18	amyloid tumor	12.8	LTF, MME
19	tick-borne encephalitis	12.8	LTF, ALB
20	urolithiasis	12.7	ALB, MME
21	membranous glomerulonephritis	12.7	MME, ALB
22	hepatitis e	12.7	ALB, G6PD
23	alagille syndrome	12.7	MME, ALB
24	nephrosis	12.7	ALB, MME
25	fournier gangrene	12.6	IGHE, ALB
26	autonomic dysfunction	12.6	MME, ALB
27	constrictive pericarditis	12.6	IGHE, ALB
28	miliary tuberculosis	12.6	IGHE, ALB
29	eosinophilic gastroenteritis	12.6	IGHE, ALB
30	strongyloidiasis	12.6	ALB, IGHE
31	extrinsic allergic alveolitis	12.6	IGHE, ALB
32	respiratory failure	12.6	IGHE, G6PD
33	bronchitis	12.6	LTF, IGHE
34	vulvovaginitis	12.6	LTF, IGHE
35	obstructive lung disease	12.6	ALB, IGHE
36	asthma	12.5	IGHE, MME
37	churg-strauss syndrome	12.5	LTF, IGHE
38	short bowel syndrome	12.5	ALB, IGHE
39	iron deficiency anemia	12.5	ALB, LTF, G6PD
40	clostridium difficile	12.5	LTF, ALB
41	gastric ulcer	12.5	G6PD, LTF, ALB
42	sickle cell disease	12.5	G6PD, LTF, ALB
43	ascariasis	12.5	MME, IGHE
44	autoimmune hemolytic anemia	12.5	IGHE, G6PD
45	congestive heart failure	12.4	PITX1, ALB, MME
46	food allergy	12.4	IGHE, ALB
47	amyloidosis	12.3	LTF, ALB, MME
48	bacterial meningitis	12.2	ALB, IGHE
49	sjogren's syndrome	12.2	MME, ALB, LTF
50	pericarditis	12.2	G6PD, ALB, IGHE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acute diarrhea:

²²

Articles related to acute diarrhea:

id	Title	Authors	Year	Affiliating Genes
1	Albumin versus normal saline for dehydrated term infa nts with metabolic acidosis due to acute diarrhea. (19158801)	Han J.J.... Hong Y.S.	2009	ALB
2	bft gene subtyping in enterotoxigenic Bacteroides fra gilis isolated from children with acute diarrhea. (17166747)	Nakano V.... Avila-Campos M.J.	2007	PITX1
3	A blind, randomized comparison of racecadotril and lo peramide for stopping acute diarrhea in adults. (15770734)	Wang H.H.... Liao K.F.	2005	MME
4	Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. (15222487)	Bethell D.R.... Huang J.	2004	LTF
5	Lack of association between falciparum malaria parasitemia and acute diarrhea in Nigerian children. (9430531)	Sodeinde O.... Adeyemo A.A.	1997	G6PD
6	Action of acetorphan, an enkephalinase inhibitor, in acute diarrhea (1285638)	Baumer P.... Lecomte J.M.	1992	MME
7	Occurrence of acute diarrhea in atopic and nonatopic infants: the role of prolonged breast-feeding. (1573508)	Ruuska T.	1992	IGHE

Genes related to acute diarrhea according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PITX1	paired-like homeodomain 1	11.0	Publications
2	PYGO1	pygopus homolog 1 (Drosophila)	11.0
3	MME	membrane metallo-endopeptidase	11.0	Publications
4	LTF	lactotransferrin	11.0	Publications
5	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
6	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
7	ALB	albumin	11.0	Publications

Pathways related to acute diarrhea according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of ESR110	9.5	MME, LTF
2	Selected targets of C/EBPalpha10	9.1	ALB, LTF

Compounds related to acute diarrhea according to GeneDecks:

(show all 48)

id	Compound	Score	Top Affiliating Genes
1	fosinopril32 9 9	11.9	ALB, MME
2	bismuth32 18	10.8	ALB, LTF
3	lisinopril32 9 18 9	12.8	MME, ALB
4	iohexol32	9.8	ALB, LTF
5	enalapril32 9 9	11.8	ALB, MME
6	ampicillin32 9 9	11.8	ALB, LTF
7	cefazolin32 9 9	11.7	G6PD, ALB
8	furosemide32 42 34 9 18 9	14.7	MME, ALB
9	ceftriaxone32 9 9	11.7	G6PD, ALB
10	leupeptin32	9.6	MME, LTF
11	cellulose acetate32	9.6	ALB, G6PD
12	toluene diisocyanate32	9.6	MME, IGHE
13	glutaraldehyde32	9.6	ALB, G6PD
14	hhpa32	9.6	IGHE, ALB
15	captopril32 42 9 9	12.6	MME, ALB
16	periodate32	9.5	IGHE, LTF
17	heroin32 9 9	11.5	MME, IGHE
18	sucralfate32 9 9	11.5	ALB, IGHE
19	mycophenolic acid32 9 9	11.4	ALB, IGHE
20	budesonide32 42 9 9	12.4	LTF, IGHE
21	propofol32 9 9	11.4	IGHE, ALB
22	diazepam32 34 9 9	12.3	ALB, LTF
23	pertussis32	9.2	IGHE, LTF
24	vitamin b1232	9.2	G6PD, LTF, ALB
25	protamine32	9.1	LTF, IGHE
26	Alpha-D-Mannose9 9	10.1	IGHE, LTF
27	methacholine32 9 9	11.1	MME, IGHE, LTF
28	capsaicin32	9.1	MME, IGHE, LTF
29	aprotinin32 9 9	11.1	MME, IGHE, LTF
30	hypoxanthine32 9 18 9	12.0	LTF, G6PD
31	sulfamethoxazole32 9 9	11.0	G6PD, ALB, IGHE
32	mannitol32 9 9	10.9	G6PD, ALB, IGHE
33	cyclophosphamide32 34 9 9	11.9	IGHE, LTF, G6PD
34	thyroxine32 18	9.9	IGHE, ALB, G6PD
35	folate32	8.8	G6PD, ALB, IGHE
36	citrate32	8.8	G6PD, LTF, ALB, MME
37	n acetylcysteine32	8.8	IGHE, LTF, G6PD
38	vitamin a32 9 18 9	11.6	LTF, ALB, IGHE, MME
39	indomethacin32 9 9	10.6	LTF, ALB, IGHE, MME
40	histamine32 18	9.6	MME, IGHE, ALB, LTF
41	actinomycin d32	8.5	G6PD, LTF, IGHE, MME
42	lactate32	8.5	MME, IGHE, ALB, G6PD
43	adenylate32	8.4	G6PD, LTF, IGHE, MME
44	testosterone32 9 18 9	11.4	MME, IGHE, ALB, G6PD
45	aspartate32	8.4	G6PD, LTF, ALB, IGHE
46	estrogen32	8.2	G6PD, LTF, IGHE, MME
47	ascorbic acid32 18	9.0	MME, IGHE, ALB, LTF, G6PD
48	creatinine32	8.0	MME, IGHE, ALB, LTF, G6PD