ADE
MCID: ACT049
MIFTS: 63

Acute Disseminated Encephalomyelitis (ADE) malady

Rare diseases, Neuronal diseases categories
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Summaries for Acute Disseminated Encephalomyelitis

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Sources:
43NIH Rare Diseases, 44NINDS, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to encephalomyelitis and encephalitis. An important gene associated with Acute Disseminated Encephalomyelitis is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neural Crest Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cerebrosides and amphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are respiratory system and muscle.

NINDS:44 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:65 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually... more...

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
acute disseminated encephalomyelitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acute disseminated encephalomyelitis 8 43 44 10 49
acute disseminated encephalitis 8 49
adem 43 49
encephalomyelitis, acute disseminated 62
encephalomyelitis acute disseminated 45
ade 43


External Ids:

Disease Ontology8 DOID:639
NCIt40 C34578
MeSH35 D004673
SNOMED-CT58 83942000
ICD10 via Orphanet26 G04.0
SNOMED-CT via Orphanet59 83942000
ICD1025 G04.0

Related Diseases for Acute Disseminated Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 516)
idRelated DiseaseScoreTop Affiliating Genes
1encephalomyelitis32.1HLA-DQB1, TNF, MPZ, AQP4, MOG, IL10
2encephalitis31.1MBP, CNTF, MOG, AQP4, HLA-B
3alzheimer's disease31.0CNTF, AQP4, MPZ, HCRT, HLA-DRB1
4myelitis30.9AQP4, MBP
5neuromyelitis optica30.9MBP, MOG, AQP4
6transverse myelitis30.9AQP4, MBP
7neuritis30.9PMP22, MPZ, MBP
8optic neuritis30.8MBP, MOG, AQP4, MPZ
9subacute sclerosing panencephalitis30.8MBP, MOG
10multiple sclerosis30.8HLA-DQA1, HLA-DRB1, HCRT, TNF, MPZ, POMC
11malaria30.7CNTF, IL10, TNF, HLA-DRB1, HLA-B
12neuropathy30.7MBP, MPZ, PMP22
13obesity30.5CNTF, POMC, TNF, HCRT
14hereditary neuropathies30.4MPZ, PMP22
15narcolepsy30.4HCRT, HLA-DRB1
16hepatitis c30.4MBP, IL10, HLA-DRB1
17tetanus30.4HLA-B, MPZ, MOG, IL10, MBP
18systemic lupus erythematosus30.3HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
19vasculitis30.3HLA-B, TNF, SAG
20relapsing-remitting multiple sclerosis30.3MOG, IL10, MBP
21glaucoma30.3AQP4, CNTF, MBP
22hepatitis b30.2HLA-DQB1, HLA-DRB1, IL10
23diabetes mellitus30.2HLA-B, HLA-DQB1, HLA-DQA1, HLA-DRB1, PMP22, TNF
24plasmodium falciparum malaria30.2IL10, HLA-DRB1, HLA-B
25inflammatory bowel disease30.1HLA-B, HLA-DQB1, TNF, IL10
26leukemia30.1MBP, CNTF, TNF, HLA-DRB1, HLA-B
27schizophrenia30.0HLA-DQB1, HLA-DRB1, HCRT, AQP4, MOG, CNTF
28tuberculosis30.0HLA-DQB1, HLA-DRB1, TNF, POMC, SAG, IL10
29melanoma29.9HLA-B, HLA-DRB1, HCRT, TNF, POMC, SAG
30ischemia29.9HLA-B, HCRT, AQP4, CNTF
31asthma29.9HLA-B, HLA-DQA1, HLA-DRB1, TNF, POMC, IL10
32arthritis29.8IL10, POMC, TNF, HLA-DRB1, HLA-B
33skin disease29.8POMC, HLA-DRB1
34prion disease29.7HCRT, POMC, MBP
35polyneuropathy29.7PMP22, MPZ, CNTF, MBP
36rheumatoid arthritis29.7HLA-DQB1, HLA-DRB1, TNF, MOG, IL10, CNTF
37thyroiditis29.7POMC, HLA-DRB1
38alcoholic hepatitis29.7TNF, IL10
39sarcoidosis29.7HLA-DQB1, HLA-DRB1, TNF
40acute graft versus host disease29.7TNF, IL10
41cerebrovascular disease29.6HLA-B, AQP4, CNTF, MBP
42graft versus host disease29.6HLA-DRB1, TNF, IL10
43type 1 diabetes mellitus29.6HLA-DRB1, IL10
44hyperlipidemia type 310.8
45influenza10.8
46pneumonia10.7
47hepatitis10.6
48meningitis10.6
49measles10.5
50hepatitis a10.5

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Disseminated Encephalomyelitis

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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33MalaCards
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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

33
Brain, Spinal cord, T cells, Bone marrow, Bone, Lung, Myeloid, Heart, Liver, Retina

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5IL10, AQP4, TNF, HCRT, HLA-DQB1
2MP:00053698.2HLA-DQB1, HCRT, PMP22, TNF, MOG, IL10
3MP:00030128.0HLA-B, TNF, POMC, AQP4, IL10, CNTF
4MP:00053917.9PMP22, TNF, AQP4, SAG, MOG, IL10
5MP:00053897.7HLA-DQB1, PMP22, TNF, MPZ, IL10, MBP
6MP:00053787.5HLA-DQB1, HCRT, PMP22, TNF, POMC, AQP4
7MP:00053847.3HLA-DQB1, PMP22, TNF, MPZ, POMC, MOG
8MP:00053767.2HLA-DQB1, HCRT, TNF, MPZ, POMC, AQP4
9MP:00107686.8HLA-B, HLA-DQB1, PMP22, TNF, MPZ, POMC
10MP:00053976.8TNF, HLA-DQA1, HLA-DQB1, HLA-B, MPZ, POMC
11MP:00053876.5HLA-B, HLA-DQB1, HLA-DQA1, TNF, MPZ, POMC
12MP:00053866.4TNF, PMP22, HCRT, HLA-DQB1, HLA-B, MPZ
13MP:00036316.1MBP, HLA-B, HLA-DQB1, HCRT, PMP22, TNF

Publications for Acute Disseminated Encephalomyelitis

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Sources:
52PubMed
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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
2
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
3
Can "dissemination" include the PNS in adults with acute disseminated encephalomyelitis? (23325898)
2013
4
Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. (24330300)
2013
5
Co-morbid Guillain-BarrAc syndrome and acute disseminated encephalomyelitis. (23545617)
2013
6
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
7
Isolated brain stem lesion in children: is it acute disseminated encephalomyelitis or not? (22766674)
2013
8
Acute disseminated encephalomyelitis. (22914374)
2012
9
Acute disseminated encephalomyelitis--a prospective study of clinical profile and in-hospital outcome predictors. (22799110)
2012
10
Simultaneous development of acute disseminated encephalomyelitis and Guillain-BarrAc syndrome associated with H1N1 09 influenza vaccination. (22728497)
2012
11
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
12
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
13
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
14
Chronic sequelae of acute disseminated encephalomyelitis in a child. (20869688)
2010
15
Partial KlA1ver-Bucy syndrome in a patient with acute disseminated encephalomyelitis. (20638284)
2010
16
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
17
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. (21258155)
2010
18
Cerebellar mutism in pediatric acute disseminated encephalomyelitis. (20304329)
2010
19
Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports. (19269652)
2009
20
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
21
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
22
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
23
Neurocutaneous melanosis with acute disseminated encephalomyelitis. (17103186)
2007
24
Recurrent acute disseminated encephalomyelitis. (17351306)
2007
25
Acute disseminated encephalomyelitis. (17438235)
2007
26
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
27
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
28
Segmental myoclonus as the presenting symptom of an acute disseminated encephalomyelitis: a case report. (16530437)
2006
29
Acute disseminated encephalomyelitis associated with oral polio vaccine. (17106158)
2006
30
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
31
Acute disseminated encephalomyelitis in North Indian children: clinical profile and follow-up. (17005100)
2006
32
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
33
Acute disseminated encephalomyelitis: an update. (16286539)
2005
34
Diffusion-weighted magnetic resonance imaging of acute disseminated encephalomyelitis. (16128879)
2005
35
Acute disseminated encephalomyelitis associated with enteroviral infection. (15626964)
2004
36
Acute disseminated encephalomyelitis: clinical features and HLA-DR linkage. (15142232)
2004
37
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
38
Acute disseminated encephalomyelitis. (12391446)
2002
39
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
40
Acute disseminated encephalomyelitis developed after acute herpetic gingivostomatitis. (11211314)
2000
41
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
42
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
43
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
44
Acute disseminated encephalomyelitis: clinical and MRI study from South India. (10450798)
1999
45
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. (9339706)
1997
46
Acute disseminated encephalomyelitis probably related to a Mycoplasma pneumoniae infection. (8453818)
1993
47
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
48
Intracranial pressure monitoring in acute disseminated encephalomyelitis in childhood. (2245628)
1990
49
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974
50
Effect of nutrition on the production of acute disseminated encephalomyelitis in mice. (13416471)
1957

Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological, 30KEGG
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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PMP22, MPZ, MBP
2
Show member pathways
9.3IL10, TNF
39.0IL10, AQP4, TNF
49.0MBP, AQP4, TNF
58.9IL10, TNF, HLA-DRB1
6
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
7
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
8
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
9
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
108.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
14
Show member pathways
8.4HLA-DPA1, HLA-DQB1, HLA-DQA1, TNF
15
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
16
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
17
Show member pathways
8.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
188.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
198.1HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
20
Show member pathways
8.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
218.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
227.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MPZ
237.6HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
247.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
25
Show member pathways
7.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
26
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
27
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
287.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
29
Show member pathways
7.0IL10, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1cerebrosides4510.1MPZ, MBP
2amphetamine45 51 1112.0CNTF, POMC, HCRT
3mog (35-55)6110.0MBP, MOG
4nogo-66 (1-40)619.9MOG, MBP
5ono 2506619.9MBP, MOG
6c3bot (154-182)619.9MBP, MOG
7clomipramine45 51 1111.9HCRT, MPZ, IL10
82,3-cyclic nucleotide459.9MPZ, MBP, MOG
9opiate459.9SAG, HCRT, POMC
10plp (139-151)619.9MOG, MBP
11octadecaneuropeptide459.7CNTF, HCRT
12ganglioside459.6CNTF, MPZ, PMP22, MBP
13cdp571459.6TNF, IL10
14dodecylphosphocholine459.6POMC, MBP
15cocaine45 1110.5HCRT, MBP, CNTF, POMC
16interferon gamma459.4IL10, TNF
17dpa 1459.3HLA-DRB1, HLA-DQA1, HLA-DPA1
18carbamazepine45 51 1111.3POMC, TNF, HLA-B
19acetylcholine45 51 29 24 1113.3MOG, HCRT, POMC, CNTF, MBP
20gaba459.3CNTF, POMC, PMP22, HCRT, MBP
21silver459.3HLA-DQA1, MBP, MOG
22corticosterone45 61 2411.2MBP, HCRT, POMC, IL10
23lipoteichoic acid459.2HLA-B, IL10, TNF
24polyinosinic-polycytidylic acid459.2TNF, HLA-B, IL10
252,5-oligoadenylate459.2IL10, TNF, HLA-B
26rolipram45 61 2911.1TNF, IL10, MBP
27norepinephrine45 24 1111.1MBP, HCRT, POMC, CNTF
28histamine45 29 2411.0CNTF, HCRT, IL10, TNF, AQP4
29glatiramer acetate45 1110.0MBP, IL10, MOG, MPZ, HLA-DRB1
30ivig459.0SAG, IL10, MBP, TNF
31steroid459.0HLA-B, MPZ, PMP22, SAG, POMC
32prednisolone45 29 1110.8TNF, POMC, MBP, IL10
33adenylate458.8HLA-B, HCRT, POMC, CNTF, MBP, SAG
34alanine458.8POMC, MBP, CNTF, SAG, HCRT, HLA-DRB1
35oligonucleotide458.8HLA-DRB1, HLA-DQA1, HCRT, AQP4, HLA-DQB1, HLA-B
36methotrexate51 45 1110.7IL10, TNF, MBP, HLA-DRB1
37nitric oxide45 24 1110.6HCRT, TNF, MOG, IL10, CNTF, HLA-B
38h2o2458.6TNF, CNTF, MBP, POMC, HLA-B
39cycloheximide458.5MBP, CNTF, IL10, POMC, TNF
40pge2458.4HLA-B, TNF, POMC, SAG, IL10, CNTF
41paraffin458.4HLA-B, HLA-DQA1, POMC, SAG, IL10, MBP
42glutamate458.4CNTF, SAG, AQP4, HCRT, HLA-DRB1, HLA-DQB1
43retinoic acid45 249.4MBP, PMP22, TNF, CNTF, AQP4, HLA-B
44dexamethasone45 51 29 1111.4HLA-B, HCRT, AQP4, TNF, POMC, IL10
45tyrosine458.2CNTF, MBP, HCRT, HLA-B, HLA-DQB1, HLA-DRB1
46cyclosporin a45 29 6110.1POMC, IL10, MBP, HLA-B, TNF, SAG
47lipid458.1MBP, CNTF, MOG, MPZ, SAG, TNF
48arginine458.0HLA-DRB1, HLA-DQA1, HLA-B, PMP22, MPZ, CNTF
49serine457.7MBP, CNTF, MOG, SAG, MPZ, POMC
50aspartate457.6PMP22, POMC, MPZ, HLA-DQA1, HLA-DQB1, HLA-B

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
16Gene Ontology
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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.7MBP, PMP22
2external side of plasma membraneGO:0098979.1AQP4, TNF, HLA-DRB1
3MHC class II protein complexGO:0426138.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
4clathrin-coated endocytic vesicle membraneGO:0306698.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:0306588.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
6trans-Golgi network membraneGO:0325888.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
7endocytic vesicle membraneGO:0306668.7HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
8endosome membraneGO:0100088.7HLA-DQA1, HLA-DQB1, HLA-DPA1
9lysosomal membraneGO:0057658.5HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
10integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.4HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
11ER to Golgi transport vesicle membraneGO:0125078.4HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12Golgi membraneGO:0001398.2HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13integral component of plasma membraneGO:0058877.4HLA-B, HLA-DPA1, HLA-DQA1, HLA-DRB1, TNF, MPZ
14plasma membraneGO:0058866.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, PMP22

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DRB1, HLA-DQB1
3detection of bacteriumGO:0160459.8HLA-DRB1, HLA-B
4cellular response to estradiol stimulusGO:0713929.8AQP4, IL10
5receptor biosynthetic processGO:0328009.6IL10, TNF
6negative regulation of cytokine secretion involved in immune responseGO:0027409.6TNF, IL10
7negative regulation of interferon-gamma productionGO:0326899.5HLA-DRB1, IL10
8negative regulation of T cell proliferationGO:0421309.5IL10, HLA-DRB1
9negative regulation of growth of symbiont in hostGO:0441309.5IL10, TNF
10negative regulation of interleukin-6 productionGO:0327159.5IL10, TNF
11cellular response to interferon-gammaGO:0713469.5AQP4, HLA-DPA1
12synaptic transmissionGO:0072689.4HCRT, PMP22, MPZ, MBP
13positive regulation of cytokine secretionGO:0507159.4TNF, IL10
14response to glucocorticoidGO:0513849.3TNF, AQP4, IL10
15negative regulation of tumor necrosis factor productionGO:0327209.3IL10, POMC
16response to activityGO:0148239.2IL10, TNF
17T cell costimulationGO:0312958.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
18T cell receptor signaling pathwayGO:0508528.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
19antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.9HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
20interferon-gamma-mediated signaling pathwayGO:0603338.5HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
21cytokine-mediated signaling pathwayGO:0192218.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
22immune responseGO:0069557.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MBP

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-B
2MHC class II receptor activityGO:0323958.3HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1

Products for genes affiliated with Acute Disseminated Encephalomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Disseminated Encephalomyelitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet