ADE
MCID: ACT049
MIFTS: 60

Acute Disseminated Encephalomyelitis (ADE) malady

Neuronal diseases category

Summaries for Acute Disseminated Encephalomyelitis

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to encephalomyelitis and multiple sclerosis. An important gene associated with Acute Disseminated Encephalomyelitis is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Rheumatoid arthritis and Cytokines and Inflammatory Response. The compounds pge2 and octadecaneuropeptide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are no phenotypic analysis and muscle.

NINDS:43 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:63 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually... more...

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
acute disseminated encephalomyelitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acute disseminated encephalomyelitis 8 42 43 10 48
acute disseminated encephalitis 8 48
adem 42 48
encephalomyelitis, acute disseminated 60
encephalomyelitis acute disseminated 44
ade 42


External Ids:

Disease Ontology8 DOID:639
MeSH34 D004673
NCIt39 C34578
SNOMED-CT56 83942000
ICD10 via Orphanet26 G04.0
SNOMED-CT via Orphanet57 83942000
ICD1025 G04.0

Related Diseases for Acute Disseminated Encephalomyelitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 514)
idRelated DiseaseScoreTop Affiliating Genes
1encephalomyelitis32.2AQP4, IL10, MPZ, HLA-DQB1, TNF, MBP
2multiple sclerosis31.3HLA-DRB1, HLA-DQB1
3influenza31.1HLA-B
4encephalitis31.1MBP, MOG, AQP4, CNTF, HLA-B
5alzheimer's disease30.9HCRT, HLA-DRB1, AQP4, CNTF, MPZ
6hepatitis30.8HLA-B
7malaria30.8TNF, HLA-B, HLA-DRB1, IL10, CNTF
8meningitis30.8HLA-B
9neuromyelitis optica30.8MBP, MOG, AQP4
10measles30.7MBP
11neuritis30.7PMP22, MBP, MPZ
12optic neuritis30.7MOG, AQP4, MBP, MPZ
13subacute sclerosing panencephalitis30.6MBP, MOG
14herpes simplex30.5HLA-B
15neuropathy30.5MPZ, MBP, PMP22
16dementia30.5HCRT
17plasmodium falciparum malaria30.4HLA-DRB1, IL10, HLA-B
18tetanus30.4HLA-B, MBP, MOG, MPZ, IL10
19hepatitis c30.4HLA-DRB1, IL10, TNF
20systemic lupus erythematosus30.4HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1, TNF, IL10
21diabetes mellitus30.3POMC, HLA-DRB1, HLA-DQB1, HLA-B, TNF, PMP22
22brain disease30.2MBP, HCRT, AQP4
23breast cancer30.2MBP, HLA-B
24rheumatic fever30.2POMC
25hypertension30.2POMC
26transverse myelitis30.2MBP, AQP4
27narcolepsy30.2HLA-DRB1, HCRT
28vaccinia30.2HLA-B
29central nervous system disease30.2MOG, MBP, HCRT, CNTF
30glioblastoma multiforme30.2AQP4
31relapsing-remitting multiple sclerosis30.2MOG, IL10, MBP
32hepatitis b30.2HLA-DRB1, HLA-DQB1, IL10
33vasculitis30.2SAG, HLA-B, TNF
34inflammatory bowel disease30.2TNF, HLA-DQB1, HLA-B, IL10
35adenocarcinoma30.2HLA-B, AQP4
36leukemia30.2HLA-DRB1, MBP, CNTF, HLA-B, TNF
37tuberculosis30.1SAG, IL10, HLA-DQB1, POMC, HLA-DRB1, TNF
38melanoma30.1MBP, SAG, TNF, HLA-B, HLA-DRB1, POMC
39glaucoma30.1MBP, CNTF, AQP4
40asthma30.1POMC, IL10, HLA-DRB1, HLA-B, MBP, TNF
41pancreatitis30.0IL10
42schizophrenia30.0MOG, MBP, HLA-DRB1, HCRT, AQP4, HLA-DQB1
43sleep disorder29.9HCRT
44lung cancer29.9POMC
45arthritis29.9POMC, IL10, TNF, HLA-DRB1, HLA-B
46hepatocellular carcinoma29.8HLA-DRB1
47diabetic neuropathy29.8MPZ, CNTF, PMP22
48ischemia29.8AQP4, HCRT, CNTF, HLA-B
49rheumatoid arthritis29.8HLA-DRB1, TNF, CNTF, IL10, HLA-DQB1, MOG
50diabetic retinopathy29.6SAG

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Clinical Features for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Disseminated Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Acute Disseminated Encephalomyelitis

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Search CenterWatch for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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32MalaCards
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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

32
Brain, Spinal cord, T cells, Bone marrow, Bone, Lung, Retina, Liver, Myeloid, Heart

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.6AQP4, CNTF, POMC
2MP:00053698.1PMP22, MOG, TNF, HLA-DQB1, HCRT, CNTF
3MP:00053846.6TNF, MBP, MOG, PMP22, HLA-DQB1, HLA-B
4MP:00053976.6HLA-DQB1, TNF, MBP, MOG, HLA-B, HLA-DQA1
5MP:00053876.4MOG, MBP, TNF, HLA-DQB1, HLA-B, HLA-DQA1
6MP:00053866.4HLA-DQB1, TNF, MBP, MOG, PMP22, HLA-B
7MP:00036315.7AQP4, PMP22, MOG, SAG, MBP, TNF

Publications for Acute Disseminated Encephalomyelitis

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Sources:
50PubMed
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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
2
The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: an update post application of the 2007 consensus criteria. (23608688)
2013
3
Multimodal therapy of recurrent severe acute disseminated encephalomyelitis: the role of immunoadsorption. (24166090)
2013
4
Acute disseminated encephalomyelitis: an evaluation of 15 cases in childhood. (24217070)
2013
5
Acute disseminated encephalomyelitis associated with dengue infection: a case report with literature review. (24035291)
2013
6
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
7
Acute disseminated encephalomyelitis associated with optic neuritis and marked peri-papillary hemorrhages. (21941362)
2011
8
Acute disseminated encephalomyelitis: Treatment guidelines. (21847331)
2011
9
Acute disseminated encephalomyelitis after mixed malaria infection (Plasmodium falciparum and Plasmodium vivax) with MRI closely simulating multiple sclerosis. (21881471)
2011
10
Acute disseminated encephalomyelitis: a diagnosis to consider. (21622921)
2011
11
Clinical profile of acute disseminated encephalomyelitis in children. (21559154)
2010
12
Severe aggressive acute disseminated encephalomyelitis-like reaction after aneurysm coiling. (20023529)
2010
13
Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features. (19018840)
2009
14
Subacute sclerosing panencephalitis (SSPE) presenting as acute disseminated encephalomyelitis in a child. (19204320)
2009
15
Severe postvaccinia encephalitis with acute disseminated encephalomyelitis: recovery with early intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin. (19133803)
2009
16
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
17
Acute disseminated encephalomyelitis. (18690521)
2008
18
Recruitment criteria for acute disseminated encephalomyelitis studies: the need for consensus. (18810592)
2008
19
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
20
Diagnosing paediatric multiple sclerosis versus acute disseminated encephalomyelitis. (18039231)
2007
21
Acute disseminated encephalomyelitis in children. A descriptive study in Tehran, Iran. (17334467)
2007
22
Acute disseminated encephalomyelitis initially diagnosed as dissociative disorder. (17827422)
2007
23
Subacute sclerosing panencephalitis presenting as acute disseminated encephalomyelitis. (17202644)
2006
24
Late-onset Krabbe's disease mimicking acute disseminated encephalomyelitis. (16139737)
2005
25
The head MRI by fluid attenuated inversion recovery (FLAIR) was useful for diagnosis in the patient with post influenza vaccinal acute disseminated encephalomyelitis (ADEM)]. (15461029)
2004
26
Acute disseminated encephalomyelitis following hepatitis A virus infection. (15033204)
2004
27
Acute disseminated encephalomyelitis and mucocutaneous ulcerations. (15328568)
2004
28
An acute disseminated encephalomyelitis-like illness following alcohol withdrawal. (14584245)
2003
29
Acute disseminated encephalomyelitis (ADEM) after allogeneic bone marrow transplantation for acute myeloid leukemia. (12574963)
2003
30
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
31
Acute disseminated encephalomyelitis in adults: a reappraisal of clinical, CSF, EEG, and MRI findings. (11993533)
2002
32
Acute disseminated encephalomyelitis following dengue fever. (12111572)
2002
33
Cerebrospinal fluid levels of cytokines and soluble tumour necrosis factor receptor in acute disseminated encephalomyelitis. (11998908)
2002
34
Acute disseminated encephalomyelitis following Leptospira infection. (11528163)
2001
35
Severe depression as an initial symptom in an elderly patient with acute disseminated encephalomyelitis. (11757774)
2001
36
Increased peripheral blood interferon gamma-producing T cells in acute disseminated encephalomyelitis. (11063842)
2000
37
Postmalaria neurological syndrome: a case of acute disseminated encephalomyelitis? (10787306)
2000
38
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
39
Pathogenesis, diagnosis, and treatment of acute disseminated encephalomyelitis. (10555827)
1999
40
Detection of serum antibody against arrestin from patients with acute disseminated encephalomyelitis. (10458494)
1999
41
Acute disseminated encephalomyelitis after accidental injection of a hog vaccine: successful treatment with plasmapheresis. (9868420)
1998
42
Acute disseminated encephalomyelitis: MR and CT features. (8770258)
1996
43
Brainstem multiple sclerosis in an 11-year-old child presenting as acute disseminated encephalomyelitis. (8576560)
1995
44
A case of acute disseminated encephalomyelitis with pathologically-proven acute demyelinating lesion in the peripheral nervous system]. (7820963)
1994
45
Serial cerebral CT abnormalities in relapsing acute disseminated encephalomyelitis. (2795082)
1989
46
Acute disseminated encephalomyelitis treated with ACTH; report of a case. (13244815)
1955
47
Acute disseminated encephalomyelitis treated with A.C.T.H. (13009131)
1953
48
Effect of cortisone on experimental acute disseminated encephalomyelitis. (14913604)
1951
49
Acute disseminated encephalomyelitis following herpes zoster, vaccination, and immunization. (15407725)
1949
50
Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys. (18884901)
1948

Genetic Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 55SinoBiological, 52R&D Systems
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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9HLA-DPA1
29.2IL10, HLA-DRB1, TNF
39.2MPZ, MBP, PMP22
48.9AQP4, TNF, MBP
5
Immune response ICOS pathway in T-helper cell
Hide members
8.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
68.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
78.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
8
Hide members
8.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
98.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
10
Hide members
8.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
11
Hide members
8.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
128.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
13
Immune response NFAT in immune response
Hide members
8.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
14
Hide members
8.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
15
Hide members
8.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
16
Hide members
8.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
17
Immune response Antigen presentation by MHC class II
Hide members
8.8HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
18
Hide members
8.8HLA-DQA1, HLA-DQB1, HLA-DPA1, TNF
198.7HLA-DQA1, HLA-B, HLA-DQB1, HLA-DPA1
208.4HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL10
21
Hide members
8.4HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1, TNF
22
Hide members
8.3HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1
238.3HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1
24
Hide members
8.3HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DPA1
258.1HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1, MPZ
26
Hide members
8.0TNF, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL10
278.0TNF, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL10
287.9HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1, IL10
29
Hide members
7.8TNF, HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1
30
Hide members
7.5IL10, TNF, HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1

Compounds for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pge24410.3POMC, SAG
2octadecaneuropeptide4410.2CNTF, HCRT
3clomipramine44 49 1112.1MPZ, IL10, HCRT
4amphetamine44 1111.0CNTF, POMC, HCRT
5dexamethasone44 49 28 1113.0POMC, AQP4, HCRT
6cdp5714410.0TNF, IL10
7opiate449.9POMC, SAG, HCRT
8interferon gamma449.9TNF, IL10
9cerebrosides449.8MBP, MPZ
10plp (139-151)599.7MBP, MOG
11mog (35-55)599.7MBP, MOG
12catecholamine449.7CNTF, HCRT, POMC
13nogo-66 (1-40)599.7MBP, MOG
14c3bot (154-182)599.7MOG, MBP
15ono 2506599.7MOG, MBP
162,3-cyclic nucleotide449.6MBP, MOG, MPZ
17dpa 1449.6HLA-DPA1, HLA-DRB1, HLA-DQA1
18lipoteichoic acid449.5IL10, HLA-B, TNF
19abacavir44 49 1111.5HLA-B, TNF
202,5-oligoadenylate449.5IL10, TNF, HLA-B
21polyinosinic-polycytidylic acid449.5TNF, HLA-B, IL10
22h2o2449.5MBP, CNTF
23carbamazepine44 49 1111.5POMC, HLA-B, TNF
24dodecylphosphocholine449.5POMC, MBP
25ganglioside449.4PMP22, MPZ, MBP, CNTF
26aspartate449.4PMP22, POMC, HLA-B, MPZ, SAG
27blys449.3TNF, IL10
28cyclosporin a44 28 5911.3SAG, MBP, HLA-B
29histamine44 28 2411.3AQP4, IL10, CNTF, HCRT, TNF
30cocaine44 1110.3CNTF, HCRT, MBP, POMC
31silver449.2HLA-DQA1, MOG, MBP
32corticosterone44 59 2411.1POMC, MBP, IL10, HCRT
33gaba449.1CNTF, PMP22, POMC, MBP, HCRT
34ivig449.0SAG, TNF, IL10, MBP
35acetylcholine44 49 28 11 2413.0MOG, MBP, CNTF, HCRT, POMC
36serine448.9MPZ, MOG, POMC, HLA-B, TNF, PMP22
37prednisolone44 28 1110.9POMC, MBP, TNF, IL10
38glatiramer acetate44 119.9MPZ, MBP, IL10, HLA-DRB1, MOG
39oligonucleotide448.8HLA-B, HLA-DQB1, HLA-DQA1, HLA-DRB1, AQP4, HCRT
40nitric oxide44 11 2410.8CNTF, HLA-B, IL10, HCRT, MOG, TNF
41norepinephrine44 11 2410.8POMC, HCRT, MBP, CNTF
42methotrexate44 49 1110.7TNF, IL10, MBP, HLA-DRB1
43glutamate448.6CNTF, MBP, CYTH1, SAG, AQP4, HCRT
44alanine448.6MBP, HLA-DRB1, HCRT, SAG, CNTF, POMC
45adenylate448.5POMC, SAG, MBP, CNTF, HCRT, HLA-B
46paraffin448.3HLA-DQA1, HLA-B, MBP, SAG, POMC, IL10
47retinoic acid44 249.1AQP4, CNTF, HLA-B, TNF, MBP, PMP22
48arginine447.8PMP22, CNTF, POMC, MPZ, HLA-DQA1, HLA-DRB1
49lipid447.5HCRT, CNTF, CYTH1, HLA-B, TNF, MBP
50tyrosine447.4HLA-DQB1, HLA-B, CYTH1, MBP, CNTF, SAG

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources:
16Gene Ontology
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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.3MBP, PMP22
2MHC class II protein complexGO:0426139.0HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
3clathrin-coated endocytic vesicle membraneGO:0306699.0HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
4transport vesicle membraneGO:0306589.0HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
5trans-Golgi network membraneGO:0325889.0HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
6endocytic vesicle membraneGO:0306668.9HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
7lysosomal membraneGO:0057658.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
8integral to lumenal side of endoplasmic reticulum membraneGO:0715568.6HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DPA1
9ER to Golgi transport vesicle membraneGO:0125078.5HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1
10Golgi membraneGO:0001398.0HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1
11integral to plasma membraneGO:0058877.7TNF, HLA-DPA1, HLA-B, HLA-DRB1, HLA-DQA1, MPZ
12plasma membraneGO:0058865.6PMP22, MOG, MBP, TNF, HLA-DPA1, HLA-DQB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.3IL10
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.9HLA-DRB1, HLA-DQB1
3cellular response to estradiol stimulusGO:0713929.8AQP4, IL10
4receptor biosynthetic processGO:0328009.8TNF, IL10
5humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB1, HLA-DQB1
6detection of bacteriumGO:0160459.4HLA-DRB1, HLA-B
7response to glucocorticoid stimulusGO:0513849.4TNF, IL10, AQP4
8negative regulation of growth of symbiont in hostGO:0441309.3IL10, TNF
9T cell costimulationGO:0312959.1HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
10T cell receptor signaling pathwayGO:0508529.0HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
11antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.0HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
12interferon-gamma-mediated signaling pathwayGO:0603338.6HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DPA1
13cytokine-mediated signaling pathwayGO:0192218.5HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DPA1
14immune responseGO:0069557.7MBP, HLA-DPA1, HLA-DQB1, HLA-B, HLA-DRB1, HLA-DQA1

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323958.8HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1

Products for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources for Acute Disseminated Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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