MCID: ACT049
MIFTS: 66

Acute Disseminated Encephalomyelitis malady

Rare diseases, Neuronal diseases categories

Summaries for Acute Disseminated Encephalomyelitis

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NIH Rare Diseases:43 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards based summary: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to encephalitis and malaria. An important gene associated with Acute Disseminated Encephalomyelitis is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neural Crest Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cerebrosides and amphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and brain, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:10 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. it usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NINDS:44 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:65 Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease marked by widespread attack of... more...

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 44NINDS, 12DISEASES, 49Orphanet, 45Novoseek, 62UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 27ICD10
See all sources

Acute Disseminated Encephalomyelitis, Aliases & Descriptions:

Name: Acute Disseminated Encephalomyelitis 10 43 44 12 49
Acute Disseminated Encephalitis 10 43 49
Adem 10 43 49
 
Encephalomyelitis, Acute Disseminated 62
Encephalomyelitis Acute Disseminated 45
Ade 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
acute disseminated encephalomyelitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:639
MeSH35 D004673
NCIt40 C34578
ICD9CM29 323.61
SNOMED-CT57 83942000
Orphanet49 83597
ICD10 via Orphanet28 G04.0
ICD1027 G04.0

Related Diseases for Acute Disseminated Encephalomyelitis

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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 523)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis31.2MBP, CNTF, MOG, AQP4, HLA-B
2malaria31.0TNF, IL10
3myelitis30.9AQP4, MBP
4neuritis30.9PMP22, MPZ, MBP
5neuromyelitis optica30.9MBP, MOG, AQP4
6optic neuritis30.9MBP, MOG, AQP4, MPZ
7transverse myelitis30.9AQP4, MBP
8subacute sclerosing panencephalitis30.8MBP, MOG
9alzheimer disease30.7CNTF, AQP4, MPZ, HCRT, HLA-DRB1
10neuropathy30.7MBP, MPZ, PMP22
11systemic lupus erythematosus30.5HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
12demyelinating disease30.5MBP, HCRT, TNF, MPZ, AQP4, MOG
13obesity30.5CNTF, POMC, TNF, HCRT
14hepatitis c30.4MBP, IL10, HLA-DRB1
15tetanus30.4HLA-B, MPZ, MOG, IL10, MBP
16hereditary neuropathies30.4MPZ, PMP22
17narcolepsy30.4HCRT, HLA-DRB1
18vasculitis30.3HLA-B, TNF, SAG
19relapsing-remitting multiple sclerosis30.3MOG, IL10, MBP
20hepatitis b30.3HLA-DQB1, HLA-DRB1, IL10
21plasmodium falciparum malaria30.3IL10, HLA-DRB1, HLA-B
22uveitis30.2IL10, SAG, TNF, HLA-B
23inflammatory bowel disease30.2HLA-B, HLA-DQB1, TNF, IL10
24leukemia30.2MBP, CNTF, TNF, HLA-DRB1, HLA-B
25tuberculosis30.1HLA-DQB1, HLA-DRB1, TNF, POMC, SAG, IL10
26melanoma30.1HLA-B, HLA-DRB1, HCRT, TNF, POMC, SAG
27schizophrenia30.1HLA-DQB1, HLA-DRB1, HCRT, AQP4, MOG, CNTF
28asthma30.0HLA-B, HLA-DQA1, HLA-DRB1, TNF, POMC, IL10
29arthritis29.9IL10, POMC, TNF, HLA-DRB1, HLA-B
30ischemia29.9HLA-B, HCRT, AQP4, CNTF
31rheumatoid arthritis29.8HLA-DQB1, HLA-DRB1, TNF, MOG, IL10, CNTF
32skin disease29.7POMC, HLA-DRB1
33polyneuropathy29.7PMP22, MPZ, CNTF, MBP
34thyroiditis29.7POMC, HLA-DRB1
35alcoholic hepatitis29.7TNF, IL10
36acute graft versus host disease29.7TNF, IL10
37influenza10.8
38hyperlipidemia type 310.8
39pneumonia10.7
40meningitis10.6
41hepatitis10.6
42measles10.5
43rubella10.5
44hepatitis a10.5
45plasmodium vivax malaria10.4
46mutism10.4
47herpes simplex10.4
48leukodystrophy10.4
49lupus erythematosus10.4
50hypersomnia10.4

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Drug clinical trials:

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Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

33
Brain, Spinal cord, T cells, Bone marrow, Bone, Lung, Retina, Heart, Liver, Myeloid

FMA organs/tissues related to Acute Disseminated Encephalomyelitis:

16
Brain, Spinal cord

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5IL10, AQP4, TNF, HCRT, HLA-DQB1
2MP:00053698.2HLA-DQB1, HCRT, PMP22, TNF, MOG, IL10
3MP:00030128.0HLA-B, TNF, POMC, AQP4, IL10, CNTF
4MP:00053917.9PMP22, TNF, AQP4, SAG, MOG, IL10
5MP:00053897.7HLA-DQB1, PMP22, TNF, MPZ, IL10, MBP
6MP:00053787.5HLA-DQB1, HCRT, PMP22, TNF, POMC, AQP4
7MP:00053847.3HLA-DQB1, PMP22, TNF, MPZ, POMC, MOG
8MP:00053767.2HLA-DQB1, HCRT, TNF, MPZ, POMC, AQP4
9MP:00107686.8HLA-B, HLA-DQB1, PMP22, TNF, MPZ, POMC
10MP:00053976.8TNF, HLA-DQA1, HLA-DQB1, HLA-B, MPZ, POMC
11MP:00053876.5HLA-B, HLA-DQB1, HLA-DQA1, TNF, MPZ, POMC
12MP:00053866.4TNF, PMP22, HCRT, HLA-DQB1, HLA-B, MPZ
13MP:00036316.1MBP, HLA-B, HLA-DQB1, HCRT, PMP22, TNF

Publications for Acute Disseminated Encephalomyelitis

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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Persistent pseudobulbar affect secondary to acute disseminated encephalomyelitis. (25792370)
2015
2
Geoepidemiology of acute disseminated encephalomyelitis. (25265138)
2014
3
Treatment of acute disseminated encephalomyelitis with plasmapheresis in a 16-year-old female, a case report and literature review. (24824150)
2014
4
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
5
Acute disseminated encephalomyelitis: an uncommon presentation of hyper IgE syndrome. (25518794)
2014
6
Early rehabilitative treatment for pediatric acute disseminated encephalomyelitis: case report. (24937355)
2014
7
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
8
Can "dissemination" include the PNS in adults with acute disseminated encephalomyelitis? (23325898)
2013
9
Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. (24330300)
2013
10
Co-morbid Guillain-BarrAc syndrome and acute disseminated encephalomyelitis. (23545617)
2013
11
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
12
Isolated brain stem lesion in children: is it acute disseminated encephalomyelitis or not? (22766674)
2013
13
Acute disseminated encephalomyelitis. (22914374)
2012
14
Acute disseminated encephalomyelitis--a prospective study of clinical profile and in-hospital outcome predictors. (22799110)
2012
15
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
16
Bithalamic compromise in acute disseminated encephalomyelitis following H1N1 influenza vaccine. (21755147)
2011
17
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
18
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
19
Chronic sequelae of acute disseminated encephalomyelitis in a child. (20869688)
2010
20
Partial KlA1ver-Bucy syndrome in a patient with acute disseminated encephalomyelitis. (20638284)
2010
21
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
22
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. (21258155)
2010
23
Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports. (19269652)
2009
24
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
25
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
26
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
27
Neurocutaneous melanosis with acute disseminated encephalomyelitis. (17103186)
2007
28
Recurrent acute disseminated encephalomyelitis. (17351306)
2007
29
Acute disseminated encephalomyelitis. (17438235)
2007
30
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
31
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
32
Segmental myoclonus as the presenting symptom of an acute disseminated encephalomyelitis: a case report. (16530437)
2006
33
Acute disseminated encephalomyelitis associated with oral polio vaccine. (17106158)
2006
34
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
35
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
36
Acute disseminated encephalomyelitis: an update. (16286539)
2005
37
Diffusion-weighted magnetic resonance imaging of acute disseminated encephalomyelitis. (16128879)
2005
38
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
39
Acute disseminated encephalomyelitis. (12391446)
2002
40
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
41
Acute disseminated encephalomyelitis developed after acute herpetic gingivostomatitis. (11211314)
2000
42
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
43
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
44
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
45
Acute disseminated encephalomyelitis: clinical and MRI study from South India. (10450798)
1999
46
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. (9339706)
1997
47
Acute disseminated encephalomyelitis probably related to a Mycoplasma pneumoniae infection. (8453818)
1993
48
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
49
Intracranial pressure monitoring in acute disseminated encephalomyelitis in childhood. (2245628)
1990
50
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974

Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PMP22, MPZ, MBP
2
Show member pathways
9.3IL10, TNF
39.0IL10, AQP4, TNF
49.0MBP, AQP4, TNF
58.9IL10, TNF, HLA-DRB1
6
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
7
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
8
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
9
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
108.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
14
Show member pathways
8.4HLA-DPA1, HLA-DQB1, HLA-DQA1, TNF
15
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
16
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
17
Show member pathways
8.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
188.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
198.1HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
20
Show member pathways
8.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
218.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
227.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MPZ
237.6HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
247.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
25
Show member pathways
7.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
26
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
27
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
287.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
29
Show member pathways
7.0IL10, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Acute Disseminated Encephalomyelitis

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Compounds related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1cerebrosides4510.1MPZ, MBP
2amphetamine45 51 1312.0CNTF, POMC, HCRT
3c3bot (154-182)6110.0MOG, MBP
4ono 2506619.9MOG, MBP
5nogo-66 (1-40)619.9MOG, MBP
6mog (35-55)619.9MOG, MBP
7clomipramine45 51 1311.9IL10, MPZ, HCRT
82,3-cyclic nucleotide459.9MBP, MOG, MPZ
9opiate459.9HCRT, POMC, SAG
10plp (139-151)619.9MOG, MBP
11octadecaneuropeptide459.7CNTF, HCRT
12ganglioside459.6PMP22, MPZ, CNTF, MBP
13cdp571459.6IL10, TNF
14dodecylphosphocholine459.6MBP, POMC
15cocaine45 1310.5HCRT, POMC, CNTF, MBP
16interferon gamma459.4TNF, IL10
17dpa 1459.3HLA-DPA1, HLA-DQA1, HLA-DRB1
18carbamazepine45 51 1311.3HLA-B, TNF, POMC
19acetylcholine45 51 30 26 1313.3HCRT, POMC, MOG, CNTF, MBP
20gaba459.3MBP, CNTF, POMC, PMP22, HCRT
21silver459.3HLA-DQA1, MOG, MBP
22corticosterone45 61 2611.2HCRT, POMC, IL10, MBP
23lipoteichoic acid459.2IL10, TNF, HLA-B
242,5-oligoadenylate459.2HLA-B, TNF, IL10
25polyinosinic-polycytidylic acid459.2HLA-B, TNF, IL10
26rolipram45 61 3011.1MBP, IL10, TNF
27norepinephrine45 26 1311.1MBP, CNTF, POMC, HCRT
28histamine45 30 2611.0HCRT, TNF, AQP4, IL10, CNTF
29glatiramer acetate45 1310.0HLA-DRB1, MPZ, MOG, IL10, MBP
30ivig459.0TNF, SAG, IL10, MBP
31steroid459.0HLA-B, PMP22, MPZ, POMC, SAG
32prednisolone45 30 1310.8TNF, POMC, IL10, MBP
33adenylate458.8HLA-B, HCRT, POMC, SAG, CNTF, MBP
34alanine458.8HLA-DRB1, HCRT, POMC, SAG, CNTF, MBP
35oligonucleotide458.8HLA-B, HLA-DQB1, HLA-DQA1, HLA-DRB1, HCRT, AQP4
36methotrexate51 45 1310.7MBP, IL10, TNF, HLA-DRB1
37nitric oxide45 26 1310.6HLA-B, HCRT, TNF, MOG, IL10, CNTF
38h2o2458.6MBP, CNTF, POMC, TNF, HLA-B
39cycloheximide458.5TNF, POMC, IL10, CNTF, MBP
40pge2458.4HLA-B, TNF, POMC, SAG, IL10, CNTF
41paraffin458.4HLA-B, HLA-DQA1, POMC, SAG, IL10, MBP
42glutamate458.4HLA-DQB1, HLA-DRB1, HCRT, MPZ, AQP4, SAG
43retinoic acid45 269.4HLA-B, PMP22, TNF, AQP4, CNTF, MBP
44dexamethasone45 51 30 1311.4HLA-B, HCRT, TNF, POMC, AQP4, IL10
45tyrosine458.2HLA-B, HLA-DQB1, HLA-DRB1, HCRT, MPZ, SAG
46cyclosporin a45 30 6110.1HLA-B, TNF, POMC, SAG, IL10, MBP
47lipid458.1HLA-B, HCRT, TNF, MPZ, SAG, MOG
48arginine458.0HLA-B, HLA-DQA1, HLA-DRB1, PMP22, MPZ, POMC
49serine457.7HLA-B, PMP22, TNF, MPZ, POMC, SAG
50aspartate457.6MBP, HLA-B, HLA-DQB1, HLA-DQA1, PMP22, MPZ

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:00432189.7MBP, PMP22
2external side of plasma membraneGO:00098979.1AQP4, TNF, HLA-DRB1
3MHC class II protein complexGO:00426138.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
4clathrin-coated endocytic vesicle membraneGO:00306698.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:00306588.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
6trans-Golgi network membraneGO:00325888.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
7endocytic vesicle membraneGO:00306668.7HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
8endosome membraneGO:00100088.7HLA-DQA1, HLA-DQB1, HLA-DPA1
9lysosomal membraneGO:00057658.5HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
10integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.4HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
11ER to Golgi transport vesicle membraneGO:00125078.4HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12Golgi membraneGO:00001398.2HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13integral component of plasma membraneGO:00058877.4HLA-B, HLA-DPA1, HLA-DQA1, HLA-DRB1, TNF, MPZ
14plasma membraneGO:00058866.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, PMP22

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:000245510.0HLA-DRB1, HLA-DQB1
3detection of bacteriumGO:00160459.8HLA-DRB1, HLA-B
4cellular response to estradiol stimulusGO:00713929.8AQP4, IL10
5receptor biosynthetic processGO:00328009.6IL10, TNF
6negative regulation of cytokine secretion involved in immune responseGO:00027409.6TNF, IL10
7negative regulation of interferon-gamma productionGO:00326899.5HLA-DRB1, IL10
8negative regulation of T cell proliferationGO:00421309.5IL10, HLA-DRB1
9negative regulation of growth of symbiont in hostGO:00441309.5IL10, TNF
10negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
11cellular response to interferon-gammaGO:00713469.5AQP4, HLA-DPA1
12synaptic transmissionGO:00072689.4HCRT, PMP22, MPZ, MBP
13positive regulation of cytokine secretionGO:00507159.4TNF, IL10
14response to glucocorticoidGO:00513849.3TNF, AQP4, IL10
15negative regulation of tumor necrosis factor productionGO:00327209.3IL10, POMC
16response to activityGO:00148239.2IL10, TNF
17T cell costimulationGO:00312958.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
18T cell receptor signaling pathwayGO:00508528.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
19antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.9HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
20interferon-gamma-mediated signaling pathwayGO:00603338.5HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
21cytokine-mediated signaling pathwayGO:00192218.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
22immune responseGO:00069557.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MBP

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DRB1, HLA-B
2MHC class II receptor activityGO:00323958.3HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1

Products for genes affiliated with Acute Disseminated Encephalomyelitis

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4CDC
15ExPASy
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24GTR
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26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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