MCID: ACT049
MIFTS: 57

Acute Disseminated Encephalomyelitis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 47Orphanet, 60UMLS, 43Novoseek, 33MeSH, 38NCIt, 55SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Acute Disseminated Encephalomyelitis, Aliases & Descriptions:

Name: Acute Disseminated Encephalomyelitis 9 41 42 11 47
Acute Disseminated Encephalitis 9 41 47 60
Adem 9 41 47
 
Encephalomyelitis, Acute Disseminated 60
Encephalomyelitis Acute Disseminated 43
Ade 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
acute disseminated encephalomyelitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:639
MeSH33 D004673
NCIt38 C34578
ICD9CM27 323.61
SNOMED-CT55 83942000
Orphanet47 83597
ICD10 via Orphanet26 G04.0
ICD1025 G04.0

Summaries for Acute Disseminated Encephalomyelitis

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NIH Rare Diseases:41 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards based summary: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to transverse myelitis and myelitis. An important gene associated with Acute Disseminated Encephalomyelitis is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neural Crest Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cerebrosides and amphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and brain, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:9 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. it usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NINDS:42 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:63 Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease marked by widespread attack of... more...

Related Diseases for Acute Disseminated Encephalomyelitis

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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 522)
idRelated DiseaseScoreTop Affiliating Genes
1transverse myelitis31.3AQP4, MBP
2myelitis31.3AQP4, MBP
3neuritis31.3PMP22, MPZ, MBP
4neuromyelitis optica31.2MBP, MOG, AQP4
5subacute sclerosing panencephalitis31.2MBP, MOG
6optic neuritis31.1MBP, MOG, AQP4, MPZ
7encephalitis31.0MBP, CNTF, MOG, AQP4, HLA-B
8neuropathy30.9MBP, MPZ, PMP22
9malaria30.9TNF, IL10
10hereditary neuropathies30.9MPZ, PMP22
11narcolepsy30.8HCRT, HLA-DRB1
12alzheimer disease30.7CNTF, AQP4, MPZ, HCRT, HLA-DRB1
13obesity30.5CNTF, POMC, TNF, HCRT
14vasculitis30.3HLA-B, TNF, SAG
15relapsing-remitting multiple sclerosis30.3MOG, IL10, MBP
16hepatitis b30.2HLA-DQB1, HLA-DRB1, IL10
17skin disease30.1POMC, HLA-DRB1
18hepatitis c30.0MBP, IL10, HLA-DRB1
19plasmodium falciparum malaria30.0IL10, HLA-DRB1, HLA-B
20tetanus30.0HLA-B, MPZ, MOG, IL10, MBP
21ischemia29.9HLA-B, HCRT, AQP4, CNTF
22polyneuropathy29.9PMP22, MPZ, CNTF, MBP
23thyroiditis29.9POMC, HLA-DRB1
24uveitis29.8IL10, SAG, TNF, HLA-B
25systemic lupus erythematosus29.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
26alcoholic hepatitis29.8TNF, IL10
27inflammatory bowel disease29.8HLA-B, HLA-DQB1, TNF, IL10
28demyelinating disease29.7MBP, HCRT, TNF, MPZ, AQP4, MOG
29acute graft versus host disease29.7TNF, IL10
30schizophrenia29.6HLA-DQB1, HLA-DRB1, HCRT, AQP4, MOG, CNTF
31leukemia29.6MBP, CNTF, TNF, HLA-DRB1, HLA-B
32rheumatoid arthritis29.2HLA-DQB1, HLA-DRB1, TNF, MOG, IL10, CNTF
33arthritis29.2IL10, POMC, TNF, HLA-DRB1, HLA-B
34tuberculosis29.1HLA-DQB1, HLA-DRB1, TNF, POMC, SAG, IL10
35asthma28.8HLA-B, HLA-DQA1, HLA-DRB1, TNF, POMC, IL10
36melanoma28.8HLA-B, HLA-DRB1, HCRT, TNF, POMC, SAG
37influenza10.8
38hyperlipidemia type 310.8
39pneumonia10.7
40meningitis10.6
41hepatitis10.6
42narcolepsy 110.6HCRT
43polyradiculoneuropathy10.6PMP22
44measles10.5
45neuropathy, recurrent, with pressure palsies10.5PMP22
46retinal vasculitis10.5SAG
47pineocytoma10.5SAG
48rubella10.5
49hepatitis a10.5
50endophthalmitis10.5SAG

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Drug clinical trials:

Search ClinicalTrials for Acute Disseminated Encephalomyelitis

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

31
Brain, Spinal cord, T cells, Bone marrow, Bone, Lung, Retina, Heart, Liver, Myeloid

FMA organs/tissues related to Acute Disseminated Encephalomyelitis:

14
Brain, Spinal cord

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5IL10, AQP4, TNF, HCRT, HLA-DQB1
2MP:00053698.2HLA-DQB1, HCRT, PMP22, TNF, MOG, IL10
3MP:00030128.0HLA-B, TNF, POMC, AQP4, IL10, CNTF
4MP:00053917.9PMP22, TNF, AQP4, SAG, MOG, IL10
5MP:00053897.7HLA-DQB1, PMP22, TNF, MPZ, IL10, MBP
6MP:00053787.5HLA-DQB1, HCRT, PMP22, TNF, POMC, AQP4
7MP:00053847.3HLA-DQB1, PMP22, TNF, MPZ, POMC, MOG
8MP:00053767.2HLA-DQB1, HCRT, TNF, MPZ, POMC, AQP4
9MP:00107686.8HLA-B, HLA-DQB1, PMP22, TNF, MPZ, POMC
10MP:00053976.8TNF, HLA-DQA1, HLA-DQB1, HLA-B, MPZ, POMC
11MP:00053876.5HLA-B, HLA-DQB1, HLA-DQA1, TNF, MPZ, POMC
12MP:00053866.4TNF, PMP22, HCRT, HLA-DQB1, HLA-B, MPZ
13MP:00036316.1MBP, HLA-B, HLA-DQB1, HCRT, PMP22, TNF

Publications for Acute Disseminated Encephalomyelitis

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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Persistent pseudobulbar affect secondary to acute disseminated encephalomyelitis. (25792370)
2015
2
Geoepidemiology of acute disseminated encephalomyelitis. (25265138)
2014
3
Treatment of acute disseminated encephalomyelitis with plasmapheresis in a 16-year-old female, a case report and literature review. (24824150)
2014
4
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
5
Acute disseminated encephalomyelitis: an uncommon presentation of hyper IgE syndrome. (25518794)
2014
6
Early rehabilitative treatment for pediatric acute disseminated encephalomyelitis: case report. (24937355)
2014
7
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
8
Can "dissemination" include the PNS in adults with acute disseminated encephalomyelitis? (23325898)
2013
9
Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. (24330300)
2013
10
Co-morbid Guillain-BarrAc syndrome and acute disseminated encephalomyelitis. (23545617)
2013
11
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
12
Isolated brain stem lesion in children: is it acute disseminated encephalomyelitis or not? (22766674)
2013
13
Acute disseminated encephalomyelitis. (22914374)
2012
14
Acute disseminated encephalomyelitis--a prospective study of clinical profile and in-hospital outcome predictors. (22799110)
2012
15
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
16
Bithalamic compromise in acute disseminated encephalomyelitis following H1N1 influenza vaccine. (21755147)
2011
17
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
18
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
19
Chronic sequelae of acute disseminated encephalomyelitis in a child. (20869688)
2010
20
Partial KlA1ver-Bucy syndrome in a patient with acute disseminated encephalomyelitis. (20638284)
2010
21
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
22
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. (21258155)
2010
23
Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports. (19269652)
2009
24
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
25
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
26
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
27
Neurocutaneous melanosis with acute disseminated encephalomyelitis. (17103186)
2007
28
Recurrent acute disseminated encephalomyelitis. (17351306)
2007
29
Acute disseminated encephalomyelitis. (17438235)
2007
30
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
31
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
32
Segmental myoclonus as the presenting symptom of an acute disseminated encephalomyelitis: a case report. (16530437)
2006
33
Acute disseminated encephalomyelitis associated with oral polio vaccine. (17106158)
2006
34
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
35
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
36
Acute disseminated encephalomyelitis: an update. (16286539)
2005
37
Diffusion-weighted magnetic resonance imaging of acute disseminated encephalomyelitis. (16128879)
2005
38
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
39
Acute disseminated encephalomyelitis. (12391446)
2002
40
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
41
Acute disseminated encephalomyelitis developed after acute herpetic gingivostomatitis. (11211314)
2000
42
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
43
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
44
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
45
Acute disseminated encephalomyelitis: clinical and MRI study from South India. (10450798)
1999
46
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. (9339706)
1997
47
Acute disseminated encephalomyelitis probably related to a Mycoplasma pneumoniae infection. (8453818)
1993
48
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
49
Intracranial pressure monitoring in acute disseminated encephalomyelitis in childhood. (2245628)
1990
50
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974

Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PMP22, MPZ, MBP
2
Show member pathways
9.3IL10, TNF
39.0IL10, AQP4, TNF
49.0MBP, AQP4, TNF
58.9IL10, TNF, HLA-DRB1
6
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
7
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
8
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
9
Show member pathways
8.6HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
108.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13
Show member pathways
8.6HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
14
Show member pathways
8.4HLA-DPA1, HLA-DQB1, HLA-DQA1, TNF
15
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
16
Show member pathways
8.1HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
17
Show member pathways
8.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
188.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
198.1HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
20
Show member pathways
8.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
218.0HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
227.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MPZ
237.6HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10
247.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
25
Show member pathways
7.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF
26
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
27
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
287.4HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, TNF, IL10
29
Show member pathways
7.0IL10, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Acute Disseminated Encephalomyelitis

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Compounds related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1cerebrosides4310.1MPZ, MBP
2amphetamine43 49 1212.0CNTF, POMC, HCRT
3c3bot (154-182)5910.0MOG, MBP
4ono 2506599.9MOG, MBP
5nogo-66 (1-40)599.9MOG, MBP
6mog (35-55)599.9MOG, MBP
7clomipramine43 49 1211.9IL10, MPZ, HCRT
82,3-cyclic nucleotide439.9MBP, MOG, MPZ
9opiate439.9HCRT, POMC, SAG
10plp (139-151)599.9MOG, MBP
11octadecaneuropeptide439.7CNTF, HCRT
12ganglioside439.6PMP22, MPZ, CNTF, MBP
13cdp571439.6IL10, TNF
14dodecylphosphocholine439.6MBP, POMC
15cocaine43 1210.5HCRT, POMC, CNTF, MBP
16interferon gamma439.4TNF, IL10
17dpa 1439.3HLA-DPA1, HLA-DQA1, HLA-DRB1
18carbamazepine43 49 1211.3HLA-B, TNF, POMC
19acetylcholine43 49 28 24 1213.3HCRT, POMC, MOG, CNTF, MBP
20gaba439.3MBP, CNTF, POMC, PMP22, HCRT
21silver439.3HLA-DQA1, MOG, MBP
22corticosterone43 59 2411.2HCRT, POMC, IL10, MBP
23lipoteichoic acid439.2IL10, TNF, HLA-B
242,5-oligoadenylate439.2HLA-B, TNF, IL10
25polyinosinic-polycytidylic acid439.2HLA-B, TNF, IL10
26rolipram43 59 2811.1MBP, IL10, TNF
27norepinephrine43 24 1211.1MBP, CNTF, POMC, HCRT
28histamine43 28 2411.0HCRT, TNF, AQP4, IL10, CNTF
29glatiramer acetate43 1210.0HLA-DRB1, MPZ, MOG, IL10, MBP
30ivig439.0TNF, SAG, IL10, MBP
31steroid439.0HLA-B, PMP22, MPZ, POMC, SAG
32prednisolone43 28 1210.8TNF, POMC, IL10, MBP
33adenylate438.8HLA-B, HCRT, POMC, SAG, CNTF, MBP
34alanine438.8HLA-DRB1, HCRT, POMC, SAG, CNTF, MBP
35oligonucleotide438.8HLA-B, HLA-DQB1, HLA-DQA1, HLA-DRB1, HCRT, AQP4
36methotrexate49 43 1210.7MBP, IL10, TNF, HLA-DRB1
37nitric oxide43 24 1210.6HLA-B, HCRT, TNF, MOG, IL10, CNTF
38h2o2438.6MBP, CNTF, POMC, TNF, HLA-B
39cycloheximide438.5TNF, POMC, IL10, CNTF, MBP
40pge2438.4HLA-B, TNF, POMC, SAG, IL10, CNTF
41paraffin438.4HLA-B, HLA-DQA1, POMC, SAG, IL10, MBP
42glutamate438.4HLA-DQB1, HLA-DRB1, HCRT, MPZ, AQP4, SAG
43retinoic acid43 249.4HLA-B, PMP22, TNF, AQP4, CNTF, MBP
44dexamethasone43 49 28 1211.4HLA-B, HCRT, TNF, POMC, AQP4, IL10
45tyrosine438.2HLA-B, HLA-DQB1, HLA-DRB1, HCRT, MPZ, SAG
46cyclosporin a43 28 5910.1HLA-B, TNF, POMC, SAG, IL10, MBP
47lipid438.1HLA-B, HCRT, TNF, MPZ, SAG, MOG
48arginine438.0HLA-B, HLA-DQA1, HLA-DRB1, PMP22, MPZ, POMC
49serine437.7HLA-B, PMP22, TNF, MPZ, POMC, SAG
50aspartate437.6MBP, HLA-B, HLA-DQB1, HLA-DQA1, PMP22, MPZ

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:00432189.7MBP, PMP22
2external side of plasma membraneGO:00098979.1AQP4, TNF, HLA-DRB1
3MHC class II protein complexGO:00426138.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
4clathrin-coated endocytic vesicle membraneGO:00306698.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:00306588.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
6trans-Golgi network membraneGO:00325888.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
7endocytic vesicle membraneGO:00306668.7HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
8endosome membraneGO:00100088.7HLA-DQA1, HLA-DQB1, HLA-DPA1
9lysosomal membraneGO:00057658.5HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
10integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.4HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
11ER to Golgi transport vesicle membraneGO:00125078.4HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
12Golgi membraneGO:00001398.2HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13integral component of plasma membraneGO:00058877.4HLA-B, HLA-DPA1, HLA-DQA1, HLA-DRB1, TNF, MPZ
14plasma membraneGO:00058866.1HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, PMP22

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:000245510.0HLA-DRB1, HLA-DQB1
3detection of bacteriumGO:00160459.8HLA-DRB1, HLA-B
4cellular response to estradiol stimulusGO:00713929.8AQP4, IL10
5receptor biosynthetic processGO:00328009.6IL10, TNF
6negative regulation of cytokine secretion involved in immune responseGO:00027409.6TNF, IL10
7negative regulation of interferon-gamma productionGO:00326899.5HLA-DRB1, IL10
8negative regulation of T cell proliferationGO:00421309.5IL10, HLA-DRB1
9negative regulation of growth of symbiont in hostGO:00441309.5IL10, TNF
10negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
11cellular response to interferon-gammaGO:00713469.5AQP4, HLA-DPA1
12synaptic transmissionGO:00072689.4HCRT, PMP22, MPZ, MBP
13positive regulation of cytokine secretionGO:00507159.4TNF, IL10
14response to glucocorticoidGO:00513849.3TNF, AQP4, IL10
15negative regulation of tumor necrosis factor productionGO:00327209.3IL10, POMC
16response to activityGO:00148239.2IL10, TNF
17T cell costimulationGO:00312958.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
18T cell receptor signaling pathwayGO:00508528.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
19antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.9HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
20interferon-gamma-mediated signaling pathwayGO:00603338.5HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-B
21cytokine-mediated signaling pathwayGO:00192218.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
22immune responseGO:00069557.9HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1, MBP

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DRB1, HLA-B
2MHC class II receptor activityGO:00323958.3HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1

Products for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources for Acute Disseminated Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet