MCID: ACT049
MIFTS: 52

Acute Disseminated Encephalomyelitis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 49 50 55 14
Acute Disseminated Encephalitis 12 55 69
Adem 12 49 55
Encephalomyelitis, Acute Disseminated 69
Encephalomyelitis Acute Disseminated 51
Ade 49

Characteristics:

Orphanet epidemiological data:

55
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:639
MeSH 41 D004673
NCIt 46 C34578
SNOMED-CT 64 83942000
Orphanet 55 ORPHA83597
UMLS via Orphanet 70 C0014059
ICD10 via Orphanet 33 G04.0
ICD10 32 G04.0

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 50 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to allergic encephalomyelitis and acute hemorrhagic leukoencephalitis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and brain.

Disease Ontology : 12 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 49 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal. Last updated: 7/26/2017

Wikipedia : 72 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 32.1 MBP MOG
2 acute hemorrhagic leukoencephalitis 32.0 AQP4 MBP
3 transverse myelitis 32.0 AQP4 IL10 MBP
4 panencephalitis, subacute sclerosing 30.3 MBP MOG
5 rubella 30.2 HLA-DRB1 IL10 MOG
6 acute transverse myelitis 30.2 AQP4 IL10
7 pediatric multiple sclerosis 30.1 HLA-DQB1 HLA-DRB1 MOG
8 hemorrhagic fever 30.0 HLA-DRB1 IL10
9 myelitis 30.0 AQP4 MBP MOG
10 neuritis 30.0 AQP4 MBP MOG
11 hypersomnia 29.6 HCRT HLA-DQB1 HLA-DRB1
12 optic neuritis 29.6 AQP4 HLA-DRB1 MBP MOG
13 dengue hemorrhagic fever 29.5 HLA-DRB1 IL10
14 demyelinating disease 29.5 AQP4 IL10 MBP MOG
15 multiple sclerosis 29.4 AQP4 HLA-DQB1 HLA-DRB1 IL10 MBP MOG
16 systemic lupus erythematosus 29.0 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
17 relapsing-remitting multiple sclerosis 29.0 AQP4 IL10 MBP MOG
18 inflammatory bowel disease 28.7 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
19 neuromyelitis optica 28.6 AQP4 HCRT HLA-DRB1 MBP MOG
20 narcolepsy 27.8 AQP4 HCRT HLA-DQA1 HLA-DQB1 HLA-DRB1 MOG
21 alzheimer disease 12.0
22 dopa-responsive dystonia; segawa syndrome ad 11.9
23 hyper-ige recurrent infection syndrome, autosomal dominant 11.7
24 immunodeficiency 27b 11.6
25 myopathy, centronuclear, 1 11.5
26 renal tubular acidosis, distal, autosomal dominant 11.5
27 hypocalcemia, autosomal dominant 1 11.4
28 alzheimer disease 2 11.4
29 emery-dreifuss muscular dystrophy 2, autosomal dominant 11.2
30 post-vaccinal encephalitis 11.2
31 frontotemporal dementia 11.2
32 striatonigral degeneration, infantile 11.2
33 immune-mediated encephalomyelitis 11.2
34 postinfectious encephalomyelitis 11.2
35 dermatitis, atopic 11.1
36 early-onset, autosomal dominant alzheimer disease 11.1
37 posterior cortical atrophy 11.0
38 eosinophilic granulomatosis with polyangiitis 11.0
39 influenza 10.4
40 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
41 encephalitis 10.4
42 metal allergy 10.4 HLA-DQB1 HLA-DRB1
43 idiopathic achalasia 10.4 HLA-DQB1 IL10
44 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
45 type ii mixed cryoglobulinemia 10.4 HLA-DQB1 HLA-DRB1
46 idiopathic inflammatory myopathy 10.4 HLA-DQB1 HLA-DRB1
47 autoimmune pancreatitis 10.4 HLA-DQB1 HLA-DRB1
48 pityriasis rosea 10.4 HLA-DQB1 HLA-DRB1
49 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1
50 juvenile myasthenia gravis 10.3 HLA-DRB1 IL10

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3 Prednisolone acetate Phase 3
4 glucocorticoids Phase 3
5 Methylprednisolone acetate Phase 3
6 Methylprednisolone Hemisuccinate Phase 3
7 Gastrointestinal Agents Phase 3
8 Neuroprotective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Antiemetics Phase 3
14 Prednisolone hemisuccinate Phase 3
15 Prednisolone phosphate Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Protective Agents Phase 3
18 Autonomic Agents Phase 3
19 Antibodies, Antiphospholipid
20 Immunoglobulins
21 Antibodies
22 interferons
23 Adjuvants, Immunologic
24 Anti-Bacterial Agents
25 Anti-Infective Agents
26 Interferon Inducers
27 Krestin
28 Antibiotics, Antitubercular
29 Radiation-Protective Agents
30 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
3 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
4 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
5 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
6 Management Of Acute Disseminating Encephalomyelitis Not yet recruiting NCT03284801

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

The Foundational Model of Anatomy Ontology organs/tissues related to Acute Disseminated Encephalomyelitis:

18
Brain, Spinal Cord

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

38
Brain, Spinal Cord, Eye, T Cells, Bone, Bone Marrow, Lung

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 626)
# Title Authors Year
1
Acute disseminated encephalomyelitis following Influenza A pneumonia. ( 29445493 )
2018
2
Necrotic-hemorrhagic myelitis: A rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. ( 29249379 )
2018
3
Diffusion Tensor Imaging as a Biomarker to Differentiate Acute Disseminated Encephalomyelitis From Multiple Sclerosis at First Demyelination. ( 29167056 )
2018
4
Long-Term Neuropsychological Outcomes of Childhood Onset Acute Disseminated Encephalomyelitis (ADEM): a Meta-Analysis. ( 28364141 )
2017
5
Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. ( 28009079 )
2017
6
Human herpesvirus 6 encephalitis followed by acute disseminated encephalomyelitis in an immunocompetent adult. ( 28367948 )
2017
7
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2017
8
Acute Disseminated Encephalomyelitis Presenting as an Isolated Mesodiencephalic Junction Lesion. ( 28694629 )
2017
9
Lethal high: acute disseminated encephalomyelitis (ADEM) triggered by toxic effect of synthetic cannabinoid black mamba. ( 28433979 )
2017
10
Acute disseminated encephalomyelitis: prognostic value of early follow-up brain MRI. ( 28695361 )
2017
11
A case of CD30+ ALK1- anaplastic large cell lymphoma resembling acute disseminated encephalomyelitis. ( 28427693 )
2017
12
Paraneoplastic acute disseminated encephalomyelitis associated with multiple myeloma. ( 28427695 )
2017
13
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. ( 28931785 )
2017
14
Childhood acute disseminated encephalomyelitis: an Egyptian pilot study. ( 29222716 )
2017
15
The many faces of demyelinating diseases: acute disseminated encephalomyelitis and Guillain-BarrAc syndrome in the same patient. ( 28591395 )
2017
16
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. ( 28524368 )
2017
17
Acute Disseminated Encephalomyelitis Following Zika Virus Infection. ( 27894121 )
2017
18
Acute disseminated encephalomyelitis in dengue viral infection. ( 28625589 )
2017
19
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis. ( 28445083 )
2017
20
Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis. ( 28327523 )
2017
21
Isolated palatal weakness without optic neuritis as the presenting manifestation of multiple sclerosis and its diagnostic dilemma with acute disseminated encephalomyelitis in a young boy. ( 28469990 )
2017
22
Tumefactive acute disseminated encephalomyelitis. ( 28488621 )
2017
23
Acute disseminated encephalomyelitis in an elderly patient. ( 28656376 )
2017
24
Acute disseminated encephalomyelitis associated with debut of a late onset coeliac disease-a case report. ( 29181653 )
2017
25
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. ( 28665957 )
2017
26
X-linked Charcot-Marie-Tooth disease with GJB1 mutation presenting as acute disseminated encephalomyelitis-like illness: A case report. ( 29245364 )
2017
27
Guillain-BarrAc Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil: Detection of Viral RNA and Isolation of Virus during Late Infection. ( 29140242 )
2017
28
Acute Disseminated Encephalomyelitis: A Gray Distinction. ( 28173990 )
2017
29
Acute disseminated encephalomyelitis following Campylobacter jejuni gastroenteritis: Case report and review of the literature. ( 27888275 )
2016
30
An atypical case of acute disseminated encephalomyelitis associated with cytomegalovirus infection. ( 26856946 )
2016
31
Treatment of hemorrhagic acute disseminated encephalomyelitis with cyclophosphamide. ( 26843496 )
2016
32
Acute Disseminated Encephalomyelitis After Influenza Vaccination: A Case Report. ( 27252106 )
2016
33
Acute disseminated encephalomyelitis presenting as a brainstem encephalitis. ( 26903073 )
2016
34
Acute Disseminated Encephalomyelitis. ( 27253358 )
2016
35
Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines. ( 27803397 )
2016
36
Atypical presentations of acute disseminated encephalomyelitis (ADEM) in HIV infection. ( 27687126 )
2016
37
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus. ( 27803416 )
2016
38
Bilateral abducens nerve palsy in an infant case of fulminant acute disseminated encephalomyelitis: a case report. ( 27782818 )
2016
39
An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. ( 26984094 )
2016
40
Acute Disseminated Encephalomyelitis After Human Parechovirus Infection. ( 26741581 )
2016
41
Acute disseminated encephalomyelitis after mumps infection. ( 28349019 )
2016
42
Acute Disseminated Encephalomyelitis. ( 27322219 )
2016
43
Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report. ( 27308086 )
2016
44
Neuroleptic Malignant Syndrome Associated with Refractory Acute Disseminated Encephalomyelitis. ( 27239186 )
2016
45
Acute Disseminated Encephalomyelitis. ( 27253359 )
2016
46
Acute disseminated encephalomyelitis complicating dengue infection with neuroimaging mimicking multiple sclerosis: A report of two cases. ( 27919476 )
2016
47
Acute disseminated encephalomyelitis: A clinical and neuroradiological profile of pediatric patients. ( 27841184 )
2016
48
Clinical Profiles and Short-Term Outcomes of Acute Disseminated Encephalomyelitis in Adult Chinese Patients. ( 27449911 )
2016
49
Cardiogenic shock from atypical Takotsubo cardiomyopathy attributed to acute disseminated encephalomyelitis lesion involving the medulla. ( 26868678 )
2016
50
Long-Term Neurocognitive, Psychosocial, and Magnetic Resonance Imaging Outcomes in Pediatric-Onset Acute Disseminated Encephalomyelitis. ( 26996404 )
2016

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.76 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.71 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
4
Show member pathways
12.7 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.6 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.47 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
7
Show member pathways
12.43 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
8
Show member pathways
12.39 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 12.3 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.27 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11
Show member pathways
12.23 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12
Show member pathways
12.1 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 12.03 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
14 12.03 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
15 11.99 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
16
Show member pathways
11.93 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
17 11.82 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
18
Show member pathways
11.82 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.81 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
20 11.77 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.72 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.66 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 11.52 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
24
Show member pathways
11.22 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 11.09 HLA-DRB1 IL10
26 10.77 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.78 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.76 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 endosome membrane GO:0010008 9.73 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.71 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.62 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.56 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.92 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.71 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 immune response GO:0006955 9.63 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 MBP
4 T cell costimulation GO:0031295 9.62 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.56 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 negative regulation of T cell proliferation GO:0042130 9.51 HLA-DRB1 IL10
7 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 IL10
8 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.48 IL10 MBP
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.46 HLA-DQB1 HLA-DRB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
11 antigen processing and presentation GO:0019882 9.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.92 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.92 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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