ADE
MCID: ACT049
MIFTS: 67

Acute Disseminated Encephalomyelitis (ADE) malady

Rare diseases, Neuronal diseases categories
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Summaries for Acute Disseminated Encephalomyelitis

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NIH Rare Diseases:42 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards based summary: Acute Disseminated Encephalomyelitis, also known as adem, is related to neuromyelitis optica and transverse myelitis. An important gene associated with Acute Disseminated Encephalomyelitis is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neural Crest Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cerebrosides and amphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and brain, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:8 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. it usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NINDS:43 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:65 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually... more...

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
43NINDS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Acute Disseminated Encephalomyelitis, Aliases & Descriptions:

Name: Acute Disseminated Encephalomyelitis 8 42 43 10 48
Adem 8 42 48
Acute Disseminated Encephalitis 8 48
Encephalomyelitis, Acute Disseminated 62
 
Encephalomyelitis Acute Disseminated 44
Adie's Syndrome 43
Ade 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
acute disseminated encephalomyelitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:639
NCIt39 C34578
MeSH34 D004673
SNOMED-CT57 83942000
ICD9CM27 323.61
ICD10 via Orphanet26 G04.0
ICD1025 G04.0

Related Diseases for Acute Disseminated Encephalomyelitis

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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 540)
idRelated DiseaseScoreTop Affiliating Genes
1neuromyelitis optica31.2MBP, MOG, AQP4
2transverse myelitis31.2AQP4, MBP
3subacute sclerosing panencephalitis31.2MOG, MBP
4myelitis31.2AQP4, MBP
5neuritis31.2MBP, MPZ, PMP22
6optic neuritis31.0MBP, MOG, AQP4, MPZ
7alzheimer's disease31.0AQP4, MPZ, HCRT, CNTF, HLA-DRB1
8encephalitis31.0HLA-B, AQP4, MOG, CNTF, MBP
9neuropathy30.9MPZ, MBP, PMP22
10hereditary neuropathies30.9MPZ, PMP22
11narcolepsy30.8HCRT, HLA-DRB1
12obesity30.5HCRT, TNF, CNTF, POMC
13vasculitis30.3HLA-B, SAG, TNF
14chronic inflammatory demyelinating polyneuropathy30.3PMP22, MPZ
15relapsing-remitting multiple sclerosis30.3IL10, MOG, MBP
16hepatitis b30.2HLA-DRB1, HLA-DQB1, IL10
17malaria30.2CNTF, IL10, HLA-B, TNF, HLA-DRB1
18skin disease30.1POMC, HLA-DRB1
19hepatitis c30.0HLA-DRB1, MBP, IL10
20plasmodium falciparum malaria30.0IL10, HLA-B, HLA-DRB1
21tetanus30.0HLA-B, MOG, IL10, MBP, MPZ
22prion disease30.0HCRT, POMC, MBP
23ischemia29.9CNTF, HCRT, AQP4, HLA-B
24polyneuropathy29.9CNTF, MBP, PMP22, MPZ
25thyroiditis29.9POMC, HLA-DRB1
26uveitis29.9HLA-B, TNF, IL10, SAG
27cerebrovascular disease29.8CNTF, AQP4, HLA-B, MBP
28inflammatory bowel disease29.8HLA-B, TNF, IL10, HLA-DQB1
29alcoholic hepatitis29.8IL10, TNF
30sarcoidosis29.7HLA-DQB1, TNF, HLA-DRB1
31demyelinating disease29.7HCRT, TNF, MPZ, AQP4, MOG, IL10
32systemic lupus erythematosus29.7HLA-DQA1, IL10, HLA-DPA1, TNF, HLA-DQB1, HLA-DRB1
33schizophrenia29.6HLA-DQB1, MBP, HLA-DRB1, HCRT, AQP4, CNTF
34acute graft versus host disease29.6TNF, IL10
35leukemia29.6HLA-B, HLA-DRB1, CNTF, TNF, MBP
36diabetes mellitus29.5HLA-B, TNF, POMC, PMP22, HLA-DRB1, HLA-DQA1
37type 1 diabetes mellitus29.5IL10, HLA-DRB1
38graft versus host disease29.5HLA-DRB1, TNF, IL10
39rheumatoid arthritis29.2MOG, CNTF, IL10, TNF, HLA-DQB1, HLA-DRB1
40arthritis29.2POMC, HLA-B, HLA-DRB1, IL10, TNF
41tuberculosis29.1TNF, IL10, SAG, MBP, HLA-DQB1, HLA-DRB1
42multiple sclerosis28.8MPZ, POMC, AQP4, SAG, IL10, CNTF
43asthma28.8IL10, HLA-DRB1, POMC, HLA-B, TNF, MBP
44melanoma28.8HLA-B, SAG, MBP, TNF, HCRT, HLA-DRB1
45influenza10.8
46hyperlipidemia type 310.8
47pneumonia10.7
48hepatitis10.6
49meningitis10.6
50narcolepsy 110.6HCRT

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Drug clinical trials:

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Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

32
Brain, Spinal cord, T cells, Bone marrow, Bone, Lung, Retina, Heart, Liver, Myeloid

FMA organs/tissues related to Acute Disseminated Encephalomyelitis:

14
Brain, Spinal cord

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5IL10, HLA-DQB1, TNF, HCRT, AQP4
2MP:00053698.2HLA-DQB1, HCRT, CNTF, IL10, MOG, TNF
3MP:00030128.0HLA-B, TNF, POMC, AQP4, IL10, CNTF
4MP:00053917.9PMP22, TNF, IL10, AQP4, SAG, MOG
5MP:00053897.7IL10, MBP, MPZ, TNF, PMP22, HLA-DQB1
6MP:00053787.5PMP22, TNF, IL10, MOG, AQP4, POMC
7MP:00053847.3POMC, HLA-DQB1, PMP22, TNF, MPZ, IL10
8MP:00053767.2POMC, MBP, CNTF, IL10, MPZ, TNF
9MP:00107686.8HLA-DQB1, TNF, POMC, HLA-B, AQP4, IL10
10MP:00053976.8CNTF, IL10, HLA-DQB1, MBP, HLA-DQA1, HLA-B
11MP:00053876.5TNF, HLA-DQA1, HLA-DQB1, HLA-B, MPZ, POMC
12MP:00053866.4HLA-DQB1, PMP22, HLA-B, HCRT, CNTF, IL10
13MP:00036316.1AQP4, MBP, CNTF, IL10, MOG, SAG

Publications for Acute Disseminated Encephalomyelitis

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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Geoepidemiology of acute disseminated encephalomyelitis. (25265138)
2014
2
Treatment of acute disseminated encephalomyelitis with plasmapheresis in a 16-year-old female, a case report and literature review. (24824150)
2014
3
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
4
Early rehabilitative treatment for pediatric acute disseminated encephalomyelitis: case report. (24937355)
2014
5
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
6
Can "dissemination" include the PNS in adults with acute disseminated encephalomyelitis? (23325898)
2013
7
Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. (24330300)
2013
8
Co-morbid Guillain-BarrAc syndrome and acute disseminated encephalomyelitis. (23545617)
2013
9
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
10
Isolated brain stem lesion in children: is it acute disseminated encephalomyelitis or not? (22766674)
2013
11
Acute disseminated encephalomyelitis. (22914374)
2012
12
Acute disseminated encephalomyelitis--a prospective study of clinical profile and in-hospital outcome predictors. (22799110)
2012
13
Simultaneous development of acute disseminated encephalomyelitis and Guillain-BarrAc syndrome associated with H1N1 09 influenza vaccination. (22728497)
2012
14
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
15
Bithalamic compromise in acute disseminated encephalomyelitis following H1N1 influenza vaccine. (21755147)
2011
16
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
17
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
18
Chronic sequelae of acute disseminated encephalomyelitis in a child. (20869688)
2010
19
Partial KlA1ver-Bucy syndrome in a patient with acute disseminated encephalomyelitis. (20638284)
2010
20
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
21
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. (21258155)
2010
22
Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports. (19269652)
2009
23
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
24
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
25
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
26
Recurrent acute disseminated encephalomyelitis. (17351306)
2007
27
Acute disseminated encephalomyelitis. (17438235)
2007
28
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
29
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
30
Segmental myoclonus as the presenting symptom of an acute disseminated encephalomyelitis: a case report. (16530437)
2006
31
Acute disseminated encephalomyelitis associated with oral polio vaccine. (17106158)
2006
32
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
33
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
34
Acute disseminated encephalomyelitis: an update. (16286539)
2005
35
Diffusion-weighted magnetic resonance imaging of acute disseminated encephalomyelitis. (16128879)
2005
36
Acute disseminated encephalomyelitis associated with enteroviral infection. (15626964)
2004
37
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
38
Acute disseminated encephalomyelitis. (12391446)
2002
39
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
40
Acute disseminated encephalomyelitis developed after acute herpetic gingivostomatitis. (11211314)
2000
41
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
42
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
43
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
44
Acute disseminated encephalomyelitis: clinical and MRI study from South India. (10450798)
1999
45
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. (9339706)
1997
46
Acute disseminated encephalomyelitis probably related to a Mycoplasma pneumoniae infection. (8453818)
1993
47
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
48
Intracranial pressure monitoring in acute disseminated encephalomyelitis in childhood. (2245628)
1990
49
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974
50
Effect of nutrition on the production of acute disseminated encephalomyelitis in mice. (13416471)
1957

Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Expression patterns in normal tissues for genes affiliated with Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4MPZ, PMP22, MBP
2
Show member pathways
9.3TNF, IL10
39.0IL10, AQP4, TNF
49.0MBP, AQP4, TNF
58.9HLA-DRB1, IL10, TNF
6
Show member pathways
8.6HLA-DRB1, HLA-DQB1, HLA-DPA1, HLA-DQA1
7
Show member pathways
8.6HLA-DPA1, HLA-DRB1, HLA-DQA1, HLA-DQB1
8
Show member pathways
8.6HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-DQB1
9
Show member pathways
8.6HLA-DRB1, HLA-DPA1, HLA-DQB1, HLA-DQA1
108.6HLA-DPA1, HLA-DRB1, HLA-DQB1, HLA-DQA1
11
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6HLA-DRB1, HLA-DPA1, HLA-DQB1, HLA-DQA1
12
Show member pathways
8.6HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
13
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.6HLA-DRB1, HLA-DPA1, HLA-DQB1, HLA-DQA1
14
Show member pathways
8.4HLA-DQB1, TNF, HLA-DPA1, HLA-DQA1
15
Show member pathways
8.1HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1, HLA-B
16
Show member pathways
8.1HLA-DPA1, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-B
17
Show member pathways
8.1HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1, HLA-B
188.1HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DPA1
198.1IL10, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
208.0TNF, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
8.0HLA-DQA1, HLA-DQB1, HLA-DPA1, TNF, HLA-DRB1
227.9HLA-DPA1, MPZ, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-B
237.6HLA-DQB1, HLA-DQA1, HLA-DRB1, IL10, HLA-B, HLA-DPA1
24
Show member pathways
7.5HLA-DQA1, HLA-B, HLA-DPA1, HLA-DQB1, TNF, HLA-DRB1
257.5HLA-B, HLA-DQA1, HLA-DQB1, HLA-DPA1, TNF, HLA-DRB1
26
Show member pathways
7.4HLA-DPA1, HLA-DQB1, HLA-DRB1, TNF, IL10, HLA-DQA1
27
Show member pathways
7.4HLA-DRB1, TNF, HLA-DQA1, HLA-DQB1, HLA-DPA1, IL10
287.4HLA-DQB1, HLA-DQA1, HLA-DPA1, IL10, HLA-DRB1, TNF
29
Show member pathways
7.0IL10, HLA-B, HLA-DPA1, HLA-DQA1, HLA-DRB1, TNF

Compounds for genes affiliated with Acute Disseminated Encephalomyelitis

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Compounds related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1cerebrosides4410.1MPZ, MBP
2amphetamine44 50 1112.0CNTF, POMC, HCRT
3mog (35-55)6110.0MBP, MOG
4nogo-66 (1-40)619.9MOG, MBP
5ono 2506619.9MBP, MOG
6c3bot (154-182)619.9MBP, MOG
7clomipramine44 50 1111.9HCRT, MPZ, IL10
82,3-cyclic nucleotide449.9MPZ, MBP, MOG
9opiate449.9SAG, HCRT, POMC
10plp (139-151)619.9MOG, MBP
11octadecaneuropeptide449.7CNTF, HCRT
12ganglioside449.6CNTF, MPZ, PMP22, MBP
13cdp571449.6TNF, IL10
14dodecylphosphocholine449.6POMC, MBP
15cocaine44 1110.5HCRT, MBP, CNTF, POMC
16interferon gamma449.4IL10, TNF
17dpa 1449.3HLA-DRB1, HLA-DQA1, HLA-DPA1
18carbamazepine44 50 1111.3POMC, TNF, HLA-B
19acetylcholine44 50 28 24 1113.3MOG, HCRT, POMC, CNTF, MBP
20gaba449.3CNTF, POMC, PMP22, HCRT, MBP
21silver449.3HLA-DQA1, MBP, MOG
22corticosterone44 61 2411.2MBP, HCRT, POMC, IL10
23lipoteichoic acid449.2HLA-B, IL10, TNF
24polyinosinic-polycytidylic acid449.2TNF, HLA-B, IL10
252,5-oligoadenylate449.2IL10, TNF, HLA-B
26rolipram44 61 2811.1TNF, IL10, MBP
27norepinephrine44 24 1111.1MBP, HCRT, POMC, CNTF
28histamine44 28 2411.0CNTF, HCRT, IL10, TNF, AQP4
29glatiramer acetate44 1110.0MBP, IL10, MOG, MPZ, HLA-DRB1
30ivig449.0SAG, IL10, MBP, TNF
31steroid449.0HLA-B, MPZ, PMP22, SAG, POMC
32prednisolone44 28 1110.8TNF, POMC, MBP, IL10
33adenylate448.8HLA-B, HCRT, POMC, CNTF, MBP, SAG
34alanine448.8POMC, MBP, CNTF, SAG, HCRT, HLA-DRB1
35oligonucleotide448.8HLA-DRB1, HLA-DQA1, HCRT, AQP4, HLA-DQB1, HLA-B
36methotrexate50 44 1110.7IL10, TNF, MBP, HLA-DRB1
37nitric oxide44 24 1110.6HCRT, TNF, MOG, IL10, CNTF, HLA-B
38h2o2448.6TNF, CNTF, MBP, POMC, HLA-B
39cycloheximide448.5MBP, CNTF, IL10, POMC, TNF
40pge2448.4HLA-B, TNF, POMC, SAG, IL10, CNTF
41paraffin448.4HLA-B, HLA-DQA1, POMC, SAG, IL10, MBP
42glutamate448.4CNTF, SAG, AQP4, HCRT, HLA-DRB1, HLA-DQB1
43retinoic acid44 249.4MBP, PMP22, TNF, CNTF, AQP4, HLA-B
44dexamethasone44 50 28 1111.4HLA-B, HCRT, AQP4, TNF, POMC, IL10
45tyrosine448.2CNTF, MBP, HCRT, HLA-B, HLA-DQB1, HLA-DRB1
46cyclosporin a44 28 6110.1POMC, IL10, MBP, HLA-B, TNF, SAG
47lipid448.1MBP, CNTF, MOG, MPZ, SAG, TNF
48arginine448.0HLA-DRB1, HLA-DQA1, HLA-B, PMP22, MPZ, CNTF
49serine447.7MBP, CNTF, MOG, SAG, MPZ, POMC
50aspartate447.6PMP22, POMC, MPZ, HLA-DQA1, HLA-DQB1, HLA-B

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.7PMP22, MBP
2external side of plasma membraneGO:0098979.1HLA-DRB1, TNF, AQP4
3MHC class II protein complexGO:0426138.8HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
4clathrin-coated endocytic vesicle membraneGO:0306698.8HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:0306588.8HLA-DQB1, HLA-DPA1, HLA-DRB1, HLA-DQA1
6trans-Golgi network membraneGO:0325888.8HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
7endocytic vesicle membraneGO:0306668.7HLA-DRB1, HLA-DQA1, HLA-DPA1, HLA-DQB1
8endosome membraneGO:0100088.7HLA-DQB1, HLA-DQA1, HLA-DPA1
9lysosomal membraneGO:0057658.5HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRB1
10integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.4HLA-DRB1, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1
11ER to Golgi transport vesicle membraneGO:0125078.4HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-B
12Golgi membraneGO:0001398.2HLA-DRB1, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1
13integral component of plasma membraneGO:0058877.4AQP4, TNF, HLA-DRB1, HLA-DPA1, HLA-B, MPZ
14plasma membraneGO:0058866.1HLA-DQA1, TNF, PMP22, AQP4, MOG, HLA-DQB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DQB1, HLA-DRB1
3detection of bacteriumGO:0160459.8HLA-B, HLA-DRB1
4cellular response to estradiol stimulusGO:0713929.8AQP4, IL10
5receptor biosynthetic processGO:0328009.6TNF, IL10
6negative regulation of cytokine secretion involved in immune responseGO:0027409.6TNF, IL10
7negative regulation of interferon-gamma productionGO:0326899.6IL10, HLA-DRB1
8negative regulation of T cell proliferationGO:0421309.5IL10, HLA-DRB1
9negative regulation of growth of symbiont in hostGO:0441309.5TNF, IL10
10negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
11cellular response to interferon-gammaGO:0713469.5HLA-DPA1, AQP4
12synaptic transmissionGO:0072689.4MBP, MPZ, PMP22, HCRT
13positive regulation of cytokine secretionGO:0507159.3TNF, IL10
14response to glucocorticoidGO:0513849.3TNF, AQP4, IL10
15negative regulation of tumor necrosis factor productionGO:0327209.3IL10, POMC
16response to activityGO:0148239.2IL10, TNF
17T cell costimulationGO:0312958.9HLA-DQB1, HLA-DPA1, HLA-DRB1, HLA-DQA1
18T cell receptor signaling pathwayGO:0508528.9HLA-DQA1, HLA-DRB1, HLA-DPA1, HLA-DQB1
19antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.9HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1
20interferon-gamma-mediated signaling pathwayGO:0603338.5HLA-B, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
21cytokine-mediated signaling pathwayGO:0192218.5HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1, HLA-B
22immune responseGO:0069557.9HLA-DRB1, HLA-B, HLA-DPA1, HLA-DQB1, HLA-DQA1, MBP

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-B
2MHC class II receptor activityGO:0323958.3HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1

Products for genes affiliated with Acute Disseminated Encephalomyelitis

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Sources for Acute Disseminated Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet