ADE
MCID: ACT049
MIFTS: 49

Acute Disseminated Encephalomyelitis (ADE) malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 11 48 49 54 13
Acute Disseminated Encephalitis 11 54 68
Adem 11 48 54
 
Encephalomyelitis, Acute Disseminated 68
Encephalomyelitis Acute Disseminated 50
Ade 48

Characteristics:

Orphanet epidemiological data:

54
acute disseminated encephalomyelitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:639
MeSH39 D004673
NCIt45 C34578
SNOMED-CT62 83942000
Orphanet54 ORPHA83597
ICD10 via Orphanet31 G04.0
ICD1030 G04.0

Summaries for Acute Disseminated Encephalomyelitis

About this section
NINDS:49 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to hepatitis and aseptic meningitis. An important gene associated with Acute Disseminated Encephalomyelitis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways are African trypanosomiasis and IL-10 Pathway. Affiliated tissues include brain, spinal cord and brain.

Disease Ontology:11 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases:48 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. this may lead to damage of the layer of insulation around affected the nerves (myelin) within affected areas. adem often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (mmr). symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs.  last updated: 8/16/2016

Wikipedia:71 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

About this section

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.2HLA-B, HLA-DRB1, IL10
2aseptic meningitis29.8HLA-B, HLA-DRB1
3swine influenza29.7HLA-B, HLA-DRB1
4immunodeficiency 27b, mycobacteriosis, ad12.0
5alzheimer disease11.9
6renal tubular acidosis, distal, ad11.8
7keratosis palmoplantaris striata i, ad11.8
8emery-dreifuss muscular dystrophy 2, ad11.7
9emery-dreifuss muscular dystrophy 7, ad11.7
10epidermolysis bullosa dystrophica, ad11.7
11cutis laxa, ad11.7
12slowed nerve conduction velocity, ad11.7
13spinal muscular atrophy, lower extremity-predominant, 2, ad11.7
14familial mediterranean fever, ad11.7
15spinal muscular atrophy, lower extremity-predominant 1, ad11.7
16dopa-responsive dystonia; segawa syndrome ad11.7
17hyper-ige recurrent infection syndrome11.6
18alzheimer disease-211.5
19myopathy, centronuclear11.5
20transverse myelitis11.4
21acute hemorrhagic leukoencephalitis11.2
22post-vaccinal encephalitis11.1
23immune-mediated encephalomyelitis11.1
24postinfectious encephalomyelitis11.1
25atopic dermatitis11.0
26early-onset, autosomal dominant alzheimer disease11.0
27pick disease11.0
28influenza10.3
29encephalitis10.3
30imaizumi kuroki syndrome10.2HCRT, HLA-DQB1
31osteogenesis imperfecta congenita, microcephaly, and cataracts10.2HLA-DQA1, HLA-DQB1
32hodgkin's paragranuloma10.2HCRT, HLA-DQB1
33myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr110.2HLA-B, HLA-DQB1
34childhood electroclinical syndrome10.2IL10, IL1B
35apple allergy10.2HLA-DQB1, HLA-DRB1
36parkinson disease 1110.2IL10, IL1B
37lin-gettig syndrome10.2HLA-DQB1, HLA-DRB1
38midline interhemispheric variant of holoprosencephaly10.2HLA-DQB1, HLA-DRB1
39autosomal dominant intermediate charcot-marie-tooth10.2HLA-DQB1, HLA-DRB1
40renal agenesis meningomyelocele mullerian defect10.2HLA-DQB1, HLA-DRB1
41distal trisomy 14q10.2HLA-DQB1, HLA-DRB1
42cyclosporiasis10.2HLA-B, IL10
43malaria10.2
44pneumonia10.2
45rosacea10.2IL10, IL1B
46linear lichen planus10.1HLA-DQB1, HLA-DRB1
47night blindness10.1HLA-DQB1, HLA-DRB1
48neonatal antiphospholipid syndrome10.1HLA-DQB1, HLA-DRB1
49sacral nerve root cysts10.1HLA-B, HLA-DRB1
50penis agenesis10.1HLA-DRB1, MOG

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

About this section

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

About this section

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 46611
2ImmunoglobulinsPhase 46394
3AntibodiesPhase 46394
4
Methylprednisoloneapproved, vet_approvedPhase 3119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
5
Prednisoloneapproved, vet_approvedPhase 3119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
6Neuroprotective AgentsPhase 31716
7Methylprednisolone HemisuccinatePhase 31193
8Prednisolone hemisuccinatePhase 31193
9Protective AgentsPhase 37443
10Prednisolone phosphatePhase 31193
11Methylprednisolone acetatePhase 31193
12Prednisolone acetatePhase 31193
13Peripheral Nervous System AgentsPhase 323689
14Autonomic AgentsPhase 310150
15Anti-Inflammatory AgentsPhase 310729
16AntiemeticsPhase 34022
17Gastrointestinal AgentsPhase 38402
18glucocorticoidsPhase 35103
19HormonesPhase 314415
20Hormone AntagonistsPhase 313180
21Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 313168
22Antibodies, Antiphospholipid29
23interferons2175
24Krestin210
25Radiation-Protective Agents480
26Interferon Inducers294
27Antiviral Agents9967
28Anti-Bacterial Agents11226
29Antibiotics, Antitubercular7180
30Anti-Infective Agents22062
31Adjuvants, Immunologic2554

Interventional clinical trials:

idNameStatusNCT IDPhase
16-year Antibody Check After Third Vaccination Against Japanese EncephalitisCompletedNCT02039440Phase 4
2Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous MethylprednisoloneUnknown statusNCT00004645Phase 3
3Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological DiseasesCompletedNCT02308579
4A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in BrazilRecruitingNCT03087136
5Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple SclerosisRecruitingNCT03122873
6Biobank For MS And Other Demyelinating DiseasesActive, not recruitingNCT00445367

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

About this section

Anatomical Context for Acute Disseminated Encephalomyelitis

About this section

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

36
Brain, Spinal cord, Eye, T cells, Bone, Bone marrow, Lung

FMA organs/tissues related to Acute Disseminated Encephalomyelitis:

17
Brain, Spinal cord

Publications for Acute Disseminated Encephalomyelitis

About this section

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. (28009079)
2017
2
Acute Disseminated Encephalomyelitis Following Zika Virus Infection. (27894121)
2017
3
Weston-Hurst syndrome: a rare fulminant form of acute disseminated encephalomyelitis (ADEM). (27797801)
2016
4
Acute disseminated encephalomyelitis complicating dengue infection with neuroimaging mimicking multiple sclerosis: A report of two cases. (27919476)
2016
5
Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. (27906662)
2016
6
Atypical presentations of acute disseminated encephalomyelitis (ADEM) in HIV infection. (27687126)
2016
7
Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review. (27478662)
2016
8
Acute disseminated encephalomyelitis secondary to serogroup B meningococcal vaccine. (27772786)
2016
9
Pandemic H1N1 Vaccination and Incidence of Acute Disseminated Encephalomyelitis in Manitoba. (27608932)
2016
10
Bilateral abducens nerve palsy in an infant case of fulminant acute disseminated encephalomyelitis: a case report. (27782818)
2016
11
Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. (27164698)
2016
12
Neuroleptic Malignant Syndrome Associated with Refractory Acute Disseminated Encephalomyelitis. (27239186)
2016
13
Recurrent acute disseminated encephalomyelitis: A favorable outcome among recurrent brain diseases in pediatric patient. (27857797)
2016
14
Acute Disseminated Encephalomyelitis. (27253358)
2016
15
Acute disseminated encephalomyelitis following Campylobacter jejuni gastroenteritis: Case report and review of the literature. (27888275)
2016
16
Acute Disseminated Encephalomyelitis After Human Parechovirus Infection. (26741581)
2016
17
Acute Disseminated Encephalomyelitis. (27322219)
2016
18
Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report. (27308086)
2016
19
Acute Disseminated Encephalomyelitis in an Incarcerated Adolescent Presents as Acute Psychosis: Case Report and Literature Review. (27749808)
2016
20
Acute disseminated encephalomyelitis in children. (27841185)
2016
21
Acute disseminated encephalomyelitis: A clinical and neuroradiological profile of pediatric patients. (27841184)
2016
22
An Acute Disseminated Encephalomyelitis-Like Illness in the Elderly: Neuroimaging and Neuropathology Findings. (27896893)
2016
23
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus. (27803416)
2016
24
Acute Disseminated Encephalomyelitis After Influenza Vaccination: A Case Report. (27252106)
2016
25
Posttraumatic Acute Disseminated Encephalomyelitis in a Child Resolved by Steroid Therapy: Case Report. (26833988)
2016
26
ADHD as Sequel to Acute Disseminated Encephalomyelitis. (27053911)
2016
27
Treatment of hemorrhagic acute disseminated encephalomyelitis with cyclophosphamide. (26843496)
2016
28
Acute Disseminated Encephalomyelitis. (27253359)
2016
29
Dopa-responsive acute disseminated encephalomyelitis with marked atrophy of the striate body. (27256998)
2016
30
Diagnosis and therapy of acute disseminated encephalomyelitis and its variants. (26620160)
2016
31
Long-Term Neurocognitive, Psychosocial, and Magnetic Resonance Imaging Outcomes in Pediatric-Onset Acute Disseminated Encephalomyelitis. (26996404)
2016
32
Acute disseminated encephalomyelitis in a case of autoimmune haemolytic anaemia: a rare association. (27268491)
2016
33
Evolution of MRI abnormalities in paediatric acute disseminated encephalomyelitis. (27670632)
2016
34
Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome. (27572859)
2016
35
Atypical global Takotsubo syndrome in a patient with acute disseminated encephalomyelitis. (26992710)
2016
36
Acute disseminated encephalomyelitis presenting as a brainstem encephalitis. (26903073)
2016
37
An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. (26984094)
2016
38
An atypical case of acute disseminated encephalomyelitis associated with cytomegalovirus infection. (26856946)
2016
39
Long-term motor, cognitive and behavioral outcome of acute disseminated encephalomyelitis. (26876769)
2016
40
Pattern and Outcome of Acute Disseminated Encephalomyelitis (ADEM) in Children: Experience in a Tertiary Center, Upper Egypt. (27648197)
2016
41
Cardiogenic shock from atypical Takotsubo cardiomyopathy attributed to acute disseminated encephalomyelitis lesion involving the medulla. (26868678)
2016
42
Acute disseminated encephalomyelitis following Plasmodium vivax malaria. (27727782)
2016
43
Clinical Profiles and Short-Term Outcomes of Acute Disseminated Encephalomyelitis in Adult Chinese Patients. (27449911)
2016
44
A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride. (26754594)
2016
45
Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines. (27803397)
2016
46
Acute disseminated encephalomyelitis: current knowledge and open questions. (26037112)
2015
47
Acute disseminated encephalomyelitis following inactivated influenza vaccination in the Brazilian Amazon: a case report. (26312942)
2015
48
Acute disseminated encephalomyelitis following influenza vaccination. (25904259)
2015
49
Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection. (25662343)
2015
50
Simultaneous presentation of acute disseminated encephalomyelitis (ADEM) and systemic lupus erythematosus (SLE) after enteroviral infection: can ADEM present as the first manifestation of SLE? (25488421)
2015

Variations for Acute Disseminated Encephalomyelitis

About this section

Expression for genes affiliated with Acute Disseminated Encephalomyelitis

About this section
Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

About this section

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL10, IL1B
29.5IL10, IL1B
39.3HLA-B, IL1B
4
Show member pathways
9.0HLA-B, IL10, IL1B
59.0HLA-DRB1, IL10, IL1B
6
Show member pathways
8.7HLA-DQA1, HLA-DQB1, HLA-DRB1
78.7HLA-DQA1, HLA-DQB1, HLA-DRB1
88.7HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.7HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.7HLA-DQA1, HLA-DQB1, HLA-DRB1
11
Show member pathways
8.7HLA-DQA1, HLA-DQB1, HLA-DRB1
12
Show member pathways
8.7HLA-DQA1, HLA-DQB1, HLA-DRB1
13
Show member pathways
8.3HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
148.3HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
15
Show member pathways
8.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
168.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
17
Show member pathways
8.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
188.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
198.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
208.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
218.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
227.8HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
23
Show member pathways
7.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
24
Show member pathways
7.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
257.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
26
Show member pathways
7.5HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
27
Show member pathways
7.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
28
Show member pathways
7.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

About this section

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.4HLA-DQA1, HLA-DQB1, HLA-DRB1
2endocytic vesicle membraneGO:00306669.4HLA-DQA1, HLA-DQB1, HLA-DRB1
3endosome membraneGO:00100089.4HLA-DQA1, HLA-DQB1, HLA-DRB1
4MHC class II protein complexGO:00426139.2HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325889.1HLA-DQA1, HLA-DQB1, HLA-DRB1
6ER to Golgi transport vesicle membraneGO:00125078.8HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
7Golgi membraneGO:00001398.7HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
8integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.7HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
9transport vesicle membraneGO:00306588.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of heterotypic cell-cell adhesionGO:003411510.4IL10, MBP
2negative regulation of interferon-gamma productionGO:003268910.2HLA-DRB1, IL10
3humoral immune response mediated by circulating immunoglobulinGO:000245510.2HLA-DQB1, HLA-DRB1
4negative regulation of T cell proliferationGO:004213010.2HLA-DRB1, IL10
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.1HLA-DQB1, HLA-DRB1
6positive regulation of interleukin-6 secretionGO:200077810.1IL1B, MBP
7positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL10, IL1B
8antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.4HLA-DQA1, HLA-DQB1, HLA-DRB1
9antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.4HLA-DQA1, HLA-DQB1, HLA-DRB1
10T cell costimulationGO:00312959.2HLA-DQA1, HLA-DQB1, HLA-DRB1
11antigen processing and presentationGO:00198828.9HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
12interferon-gamma-mediated signaling pathwayGO:00603338.8HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
13T cell receptor signaling pathwayGO:00508528.7HLA-DQA1, HLA-DQB1, HLA-DRB1
14immune responseGO:00069557.5HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.1HLA-DQA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426058.2HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet