MCID: ACT049
MIFTS: 49

Acute Disseminated Encephalomyelitis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Acute Disseminated Encephalomyelitis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 46NINDS, 12DISEASES, 51Orphanet, 65UMLS, 47Novoseek, 59SNOMED-CT, 29ICD9CM, 36MeSH, 42NCIt, 28ICD10 via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 10 45 46 12 51
Acute Disseminated Encephalitis 10 51 65
Adem 10 45 51
 
Encephalomyelitis, Acute Disseminated 65
Encephalomyelitis Acute Disseminated 47
Ade 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
acute disseminated encephalomyelitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:639
ICD9CM29 323.61
MeSH36 D004673
NCIt42 C34578
SNOMED-CT59 83942000
Orphanet51 83597
ICD10 via Orphanet28 G04.0
ICD1027 G04.0

Summaries for Acute Disseminated Encephalomyelitis

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NIH Rare Diseases:45 Acute disseminated encephalomyelitis (adem) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  it often follows viral infection, or less often, vaccination for measles, mumps, or rubella. treatment for adem is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. plasmapheresis or intravenous immunoglobulin therapy may also be used.  additional treatment is symptomatic and supportive.  last updated: 10/31/2011

MalaCards based summary: Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to acquired immunodeficiency syndrome and vulvovaginal candidiasis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways are IL-10 Pathway and African trypanosomiasis. Affiliated tissues include brain, spinal cord and brain, and related mouse phenotypes are behavior/neurological and hematopoietic system.

Disease Ontology:10 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. it usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NINDS:46 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin ? the protective covering of nerve fibers.

Wikipedia:68 Acute disseminated encephalomyelitis (ADEM) (or acute demyelinating encephalomyelitis) is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

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Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1363)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.4IL10, IL1B, MBP
2vulvovaginal candidiasis30.4HLA-DRB1, IL1B
3systemic lupus erythematosus30.4HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
4bone marrow cancer30.3HLA-DQA1, HLA-DQB1, HLA-DRB1
5diabetes mellitus, insulin-dependent30.2HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
6early-onset, autosomal dominant alzheimer disease30.2IL10, IL1B
7asthma30.1HLA-DQA1, HLA-DQB1, IL10, IL1B
8eye accommodation disease30.1IL10, IL1B
9neuroendocrine tumor29.8IL1B, MBP, MPZ
10rheumatoid arthritis29.8HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
11clear cell renal cell carcinoma29.7IL10, IL1B
12protein-energy malnutrition29.6IL10, IL1B
13autoimmune disease of skin and connective tissue29.5HLA-DQA1, HLA-DQB1
14lens disease29.2HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
15multiple sclerosis, disease progression, modifier of29.2HLA-DQB1, HLA-DRB1, IL10, IL1B, MBP, MOG
16neutropenia29.1HCRT, HLA-DRB1, MBP, MOG
17demyelinating polyneuropathy29.1IL10, IL1B, MBP, MOG
18influenza10.9
19encephalitis10.8
20alzheimer disease10.7
21pneumonia10.7
22dementia10.7
23hyperlipidemia type 310.7
24malaria10.7
25meningitis10.7
26subacute delirium10.7
27amnestic disorder10.7
28tauopathy10.6
29prion disease10.6
30central nervous system disease10.6
31hepatitis10.6
32diabetes mellitus, noninsulin-dependent10.6
33neuromyelitis optica10.6
34myelitis10.6
35neuritis10.6
36optic neuritis10.6
37mody, type ii10.6
38diabetes mellitus, noninsulin-dependent, 210.6
39drug psychosis10.6
40nervous system disease10.6
41measles10.6
42transverse myelitis10.6
43diabetes mellitus, noninsulin-dependent 110.5
44hepatitis a10.5
45plasmodium vivax malaria10.5
46rubella10.5
47subacute sclerosing panencephalitis10.5
48demyelinating disease10.5
49skin conditions10.5
50skin disease10.5

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to acute disseminated encephalomyelitis

Symptoms for Acute Disseminated Encephalomyelitis

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Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

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Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethylprednisoloneapprovedPhase 3103383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
PrednisoloneapprovedPhase 3103350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3Prednisolone phosphatePhase 31033
4Prednisolone hemisuccinatePhase 31033
5Prednisolone acetatePhase 31033
6Methylprednisolone acetatePhase 31033
7Methylprednisolone HemisuccinatePhase 31033

Interventional clinical trials:

idNameStatusNCT IDPhase
16-year Antibody Check After Third Vaccination Against Japanese EncephalitisCompletedNCT02039440Phase 4
2Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous MethylprednisoloneActive, not recruitingNCT00004645Phase 3
3Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological DiseasesCompletedNCT02308579
4Biobank For MS And Other Demyelinating DiseasesActive, not recruitingNCT00445367

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

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Anatomical Context for Acute Disseminated Encephalomyelitis

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MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

33
Brain, Spinal cord, Bone, T cells, Bone marrow, Lung, Myeloid

FMA organs/tissues related to Acute Disseminated Encephalomyelitis:

16
Brain, Spinal cord

Animal Models for Acute Disseminated Encephalomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.8HCRT, HLA-DQB1, IL10, MBP, MOG, MPZ
2MP:00053976.9HLA-DQA1, HLA-DQB1, IL10, IL1B, MBP, MOG
3MP:00036316.9HCRT, HLA-DQB1, IL10, IL1B, MBP, MOG
4MP:00053876.6HLA-DQA1, HLA-DQB1, IL10, IL1B, MBP, MOG

Publications for Acute Disseminated Encephalomyelitis

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Articles related to Acute Disseminated Encephalomyelitis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Persistent pseudobulbar affect secondary to acute disseminated encephalomyelitis. (25792370)
2015
2
A Case of Acute Disseminated Encephalomyelitis in a Middle-Aged Adult. (26180647)
2015
3
Geoepidemiology of acute disseminated encephalomyelitis. (25265138)
2014
4
Treatment of acute disseminated encephalomyelitis with plasmapheresis in a 16-year-old female, a case report and literature review. (24824150)
2014
5
Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children. (23143724)
2014
6
Acute disseminated encephalomyelitis: an uncommon presentation of hyper IgE syndrome. (25518794)
2014
7
Early rehabilitative treatment for pediatric acute disseminated encephalomyelitis: case report. (24937355)
2014
8
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
9
Can "dissemination" include the PNS in adults with acute disseminated encephalomyelitis? (23325898)
2013
10
Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. (24330300)
2013
11
Co-morbid Guillain-BarrAc syndrome and acute disseminated encephalomyelitis. (23545617)
2013
12
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
13
Isolated brain stem lesion in children: is it acute disseminated encephalomyelitis or not? (22766674)
2013
14
Acute disseminated encephalomyelitis. (22914374)
2012
15
Acute disseminated encephalomyelitis--a prospective study of clinical profile and in-hospital outcome predictors. (22799110)
2012
16
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
17
Bithalamic compromise in acute disseminated encephalomyelitis following H1N1 influenza vaccine. (21755147)
2011
18
Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. (20736878)
2011
19
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
20
Chronic sequelae of acute disseminated encephalomyelitis in a child. (20869688)
2010
21
Partial KlA1ver-Bucy syndrome in a patient with acute disseminated encephalomyelitis. (20638284)
2010
22
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
23
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. (21258155)
2010
24
Cerebellar mutism in pediatric acute disseminated encephalomyelitis. (20304329)
2010
25
Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports. (19269652)
2009
26
Acute disseminated encephalomyelitis: a report of two fulminant cases and review of literature. (19105115)
2008
27
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
28
Neurocutaneous melanosis with acute disseminated encephalomyelitis. (17103186)
2007
29
Recurrent acute disseminated encephalomyelitis. (17351306)
2007
30
Acute disseminated encephalomyelitis. (17438235)
2007
31
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
32
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
33
Acute disseminated encephalomyelitis associated with oral polio vaccine. (17106158)
2006
34
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
35
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
36
Acute disseminated encephalomyelitis: an update. (16286539)
2005
37
Acute disseminated encephalomyelitis associated with enteroviral infection. (15626964)
2004
38
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
39
Acute disseminated encephalomyelitis. (12391446)
2002
40
Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. (11954856)
2002
41
Acute disseminated encephalomyelitis developed after acute herpetic gingivostomatitis. (11211314)
2000
42
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
43
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
44
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
45
Acute disseminated encephalomyelitis: clinical and MRI study from South India. (10450798)
1999
46
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. (9339706)
1997
47
Acute disseminated encephalomyelitis probably related to a Mycoplasma pneumoniae infection. (8453818)
1993
48
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
49
Intracranial pressure monitoring in acute disseminated encephalomyelitis in childhood. (2245628)
1990
50
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974

Variations for Acute Disseminated Encephalomyelitis

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Expression for genes affiliated with Acute Disseminated Encephalomyelitis

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Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for genes affiliated with Acute Disseminated Encephalomyelitis

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Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2IL10, IL1B
29.2IL10, IL1B
3
Show member pathways
9.0HLA-DQA1, HLA-DQB1, HLA-DRB1
49.0HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
9.0HLA-DQA1, HLA-DQB1, HLA-DRB1
6
TCR signaling (REACTOME)
Show member pathways
9.0HLA-DQA1, HLA-DQB1, HLA-DRB1
79.0HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
9.0HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
9.0HLA-DQA1, HLA-DQB1, HLA-DRB1
109.0HLA-DQA1, HLA-DQB1, HLA-DRB1
119.0HLA-DQA1, HLA-DQB1, HLA-DRB1
128.9HLA-DRB1, IL10, IL1B
138.5HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10
158.4HLA-DQA1, HLA-DQB1, HLA-DRB1, MPZ
168.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
17
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
18
Show member pathways
7.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
19
Show member pathways
7.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B
207.7HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B

GO Terms for genes affiliated with Acute Disseminated Encephalomyelitis

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Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:00057919.6HCRT, MPZ
2MHC class II protein complexGO:00426139.3HLA-DQA1, HLA-DQB1, HLA-DRB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-DQA1, HLA-DQB1, HLA-DRB1
4myelin sheathGO:00432099.3MBP, MOG, MPZ
5ER to Golgi transport vesicle membraneGO:00125079.3HLA-DQA1, HLA-DQB1, HLA-DRB1
6endocytic vesicle membraneGO:00306669.2HLA-DQA1, HLA-DQB1, HLA-DRB1
7clathrin-coated endocytic vesicle membraneGO:00306699.2HLA-DQA1, HLA-DQB1, HLA-DRB1
8trans-Golgi network membraneGO:00325889.1HLA-DQA1, HLA-DQB1, HLA-DRB1
9lysosomal membraneGO:00057658.9HLA-DQA1, HLA-DQB1, HLA-DRB1
10transport vesicle membraneGO:00306588.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interferon-gamma productionGO:003268910.2HLA-DRB1, IL10
2negative regulation of T cell proliferationGO:004213010.1HLA-DRB1, IL10
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.1HLA-DQB1, HLA-DRB1
4humoral immune response mediated by circulating immunoglobulinGO:000245510.0HLA-DQB1, HLA-DRB1
5inflammatory response to antigenic stimulusGO:00024379.9HLA-DRB1, IL1B
6antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.6HLA-DQA1, HLA-DQB1, HLA-DRB1
7interferon-gamma-mediated signaling pathwayGO:00603339.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8T cell costimulationGO:00312959.4HLA-DQA1, HLA-DQB1, HLA-DRB1
9antigen processing and presentationGO:00198829.4HLA-DQA1, HLA-DQB1, HLA-DRB1
10T cell receptor signaling pathwayGO:00508529.3HLA-DQA1, HLA-DQB1, HLA-DRB1
11antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.1HLA-DQA1, HLA-DQB1, HLA-DRB1
12agingGO:00075688.9IL10, IL1B, MOG
13cytokine-mediated signaling pathwayGO:00192217.8HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1B
14immune responseGO:00069557.5HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL1B, MBP

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.2HLA-DQA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426059.0HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet