MCID: ACT069
MIFTS: 22

Acute Endometritis

Categories: Reproductive diseases

Aliases & Classifications for Acute Endometritis

MalaCards integrated aliases for Acute Endometritis:

Name: Acute Endometritis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7528
NCIt 46 C27022
SNOMED-CT 64 155976002 67667007
UMLS 69 C0238103

Summaries for Acute Endometritis

MalaCards based summary : Acute Endometritis is related to endometritis and bacteremia 2. An important gene associated with Acute Endometritis is NLRC5 (NLR Family CARD Domain Containing 5), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Acute Endometritis

Diseases in the Endometritis family:

Acute Endometritis

Diseases related to Acute Endometritis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 endometritis 10.0
2 bacteremia 2 9.7
3 influenza 9.7
4 haemophilus influenzae 9.7
5 endometrial disease 9.6 NLRC5 PTGS2

Graphical network of the top 20 diseases related to Acute Endometritis:



Diseases related to Acute Endometritis

Symptoms & Phenotypes for Acute Endometritis

GenomeRNAi Phenotypes related to Acute Endometritis according to GeneCards Suite gene sharing:

25 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.89 PTGS2 GLS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.89 PTGS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.89 PTGS2 GLS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.89 GLS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.89 GLS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.89 GLS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.89 PTGS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.89 GLS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.89 PTGS2 GLS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.89 GLS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.89 PTGS2 GLS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.89 GLS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.89 PTGS2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.8 GLS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.8 GLS PTGS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 PTGS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.8 GLS AKR1C3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.8 AKR1C3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.8 GLS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.8 GLS
21 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.8 GLS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.8 AKR1C3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 GLS
24 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.8 GLS
25 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.8 AKR1C3 PTGS2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 GLS
27 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.8 AKR1C3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.8 PTGS2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.8 AKR1C3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.8 AKR1C3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.8 GLS
32 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.8 AKR1C3

Drugs & Therapeutics for Acute Endometritis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131

Search NIH Clinical Center for Acute Endometritis

Genetic Tests for Acute Endometritis

Anatomical Context for Acute Endometritis

Publications for Acute Endometritis

Articles related to Acute Endometritis:

# Title Authors Year
1
Haemophilus influenzae acute endometritis with bacteremia: case report and literature review. ( 23537790 )
2013
2
Association between Mycoplasma genitalium and acute endometritis. ( 11888591 )
2002
3
Morphologic evaluation of acute endometritis in mares with differing resistance to uterine infections. ( 3565199 )
1986

Variations for Acute Endometritis

Expression for Acute Endometritis

Search GEO for disease gene expression data for Acute Endometritis.

Pathways for Acute Endometritis

Pathways related to Acute Endometritis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 AKR1C3 PTGIS PTGS2
2
Show member pathways
11.75 PTGIS PTGS2
3
Show member pathways
11.74 AKR1C3 PTGIS
4
Show member pathways
11.71 AKR1C3 PTGIS PTGS2
5
Show member pathways
11.5 AKR1C3 PTGIS PTGS2
6 11.16 AKR1C3 PTGS2
7 11.1 AKR1C3 PTGIS PTGS2
8 10.91 PTGIS PTGS2
9
Show member pathways
10.84 PTGIS PTGS2
10 10.75 PTGIS PTGS2
11 10.58 AKR1C3 PTGIS PTGS2
12 10.16 AKR1C3 PTGIS PTGS2

GO Terms for Acute Endometritis

Cellular components related to Acute Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGIS PTGS2

Biological processes related to Acute Endometritis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.67 AKR1C3 PTGIS PTGS2
2 fatty acid metabolic process GO:0006631 9.51 PTGIS PTGS2
3 cellular response to hypoxia GO:0071456 9.48 PTGIS PTGS2
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.46 NLRC5 PTGIS
5 fatty acid biosynthetic process GO:0006633 9.43 PTGIS PTGS2
6 positive regulation of cell death GO:0010942 9.4 AKR1C3 PTGS2
7 embryo implantation GO:0007566 9.37 PTGIS PTGS2
8 decidualization GO:0046697 9.32 PTGIS PTGS2
9 prostaglandin biosynthetic process GO:0001516 9.26 PTGIS PTGS2
10 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356 9.16 PTGIS PTGS2
11 prostaglandin metabolic process GO:0006693 9.13 AKR1C3 PTGIS PTGS2
12 cyclooxygenase pathway GO:0019371 8.8 AKR1C3 PTGIS PTGS2

Molecular functions related to Acute Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 PTGIS PTGS2

Sources for Acute Endometritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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