AFLP
MCID: ACT099
MIFTS: 49

Acute Fatty Liver of Pregnancy (AFLP) malady

Genetic diseases, Rare diseases, Liver diseases, Reproductive diseases categories

Summaries for Acute Fatty Liver of Pregnancy

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the... more...

MalaCards: Acute Fatty Liver of Pregnancy, also known as AFLP, is related to disseminated intravascular coagulation and hellp syndrome. An important gene associated with Acute Fatty Liver of Pregnancy is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Hemostasis and Collagen biosynthesis and modifying enzymes. The compounds aprosulate and napsagatran have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and pituitary, and related mouse phenotypes are cardiovascular system and embryogenesis.

Description from OMIM:48 609016

Aliases & Classifications for Acute Fatty Liver of Pregnancy

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Sources:
44NIH Rare Diseases, 48OMIM, 50Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
acute fatty liver of pregnancy:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

acute fatty liver of pregnancy 44 50
aflp 44 50
fatty liver, acute, of pregnancy 48
acute fatty liver, gestational 44


External Ids:

MESH via Orphanet37 C537957
ICD10 via Orphanet27 O26.6
SNOMED-CT via Orphanet60 91162000
UMLS via Orphanet64 C1455728

Related Diseases for Acute Fatty Liver of Pregnancy

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Acute Fatty Liver of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1disseminated intravascular coagulation31.0SERPINC1, F3, F2
2hellp syndrome30.9HADHA, SERPINC1
3cholestasis30.4HADHA, F2
4thrombocytopenia30.3F3, SERPINC1, F2
5pre-eclampsia30.3HADHA, F2, F3, SERPINC1
6hepatitis10.7
7pancreatitis10.6
8diabetes insipidus10.5
9lchad deficiency10.4
103-hydroxyacyl-coenzyme a dehydrogenase deficiency10.4
11acute liver failure10.3
12intrahepatic cholestasis10.3
13peripartum cardiomyopathy10.3
14hepatitis b10.3
15hepatic coma10.3
16eclampsia10.3
17metabolic acidosis10.3
18herpes simplex10.3
19hypertension10.3
20panniculitis10.3
21peritonitis10.3
22intrahepatic cholestasis of pregnancy10.3
23mallory-weiss syndrome10.3
24trifunctional protein deficiency10.3
25fatty acid oxidation disorders10.3
263-hydroxyacyl-coa dehydrogenase deficiency10.3
27hepatitis b virus infection10.3
28plague10.2
29hypersplenism10.1F2
30factor xii deficiency10.1F3
31carotid artery thrombosis10.1F3
32factor viii deficiency10.1F3
33purpura fulminans10.1SERPINC1
34sagittal sinus thrombosis10.1SERPINC1
35sneddon syndrome10.1SERPINC1
36purpura10.1SERPINC1
37factor x deficiency10.0F3, F2
38vitamin k deficiency hemorrhagic disease10.0F2, F3
39factor v deficiency10.0F2, F3
40factor xi deficiency10.0F2, F3
41von willebrand's disease10.0F2, F3
42afibrinogenemia10.0F3, F2
43hemophilia b10.0F2, F3
44cystic fibrosis10.0
45chikungunya10.0
46leishmaniasis10.0
47pancreatic cancer10.0
48candida glabrata10.0
49polyploidy10.0
50prothrombin deficiency10.0F2, SERPINC1

Graphical network of the top 20 diseases related to Acute Fatty Liver of Pregnancy:



Diseases related to acute fatty liver of pregnancy

Symptoms for Acute Fatty Liver of Pregnancy

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Sources:
48OMIM
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Clinical features from OMIM:

609016

Drugs & Therapeutics for Acute Fatty Liver of Pregnancy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Fatty Liver of Pregnancy

Drug clinical trials:

Search ClinicalTrials for Acute Fatty Liver of Pregnancy

Search NIH Clinical Center for Acute Fatty Liver of Pregnancy

Search CenterWatch for Acute Fatty Liver of Pregnancy

Genetic Tests for Acute Fatty Liver of Pregnancy

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Anatomical Context for Acute Fatty Liver of Pregnancy

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Sources:
34MalaCards
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MalaCards organs/tissues related to Acute Fatty Liver of Pregnancy:

34
Liver, Kidney, Pituitary

Animal Models for Acute Fatty Liver of Pregnancy or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Acute Fatty Liver of Pregnancy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1F3, SERPINC1, HADHA, F2
2MP:00053807.8F3, SERPINC1, HADHA, F2

Publications for Acute Fatty Liver of Pregnancy

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Sources:
53PubMed
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Articles related to Acute Fatty Liver of Pregnancy:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet counts. (24428400)
2014
2
Effectiveness of combining plasma exchange with continuous hemodiafiltration on acute Fatty liver of pregnancy complicated by multiple organ dysfunction. (22428588)
2012
3
Therapeutic effects of plasma exchange for the treatment of 39 patients with acute fatty liver of pregnancy. (22642918)
2012
4
Acute Fatty liver of pregnancy. (23181240)
2012
5
Early pancreatic panniculitis associated with HELLP syndrome and acute fatty liver of pregnancy. (21752052)
2011
6
Acute fatty liver of pregnancy. (21766548)
2010
7
Clinical diagnosis and treatment of acute fatty liver of pregnancy: a literature review and 11 new cases. (20666940)
2010
8
Acute fatty liver of pregnancy: a case report of an uncommon disease. (19881179)
2009
9
Acute fatty liver of pregnancy and molecular absorbent recirculating system (MARS)-therapy: a case report. (18609350)
2008
10
Recurrent acute fatty liver of pregnancy]. (18176373)
2007
11
Acute fatty liver of pregnancy. (16868757)
2006
12
Acute fatty liver of pregnancy -- an underlying condition for herpes simplex type 2 fulminant hepatitis necessitating liver transplantation. (15871067)
2005
13
The association between acute fatty liver of pregnancy and fatty acid oxidation disorders. (15673650)
2005
14
Acute fatty liver of pregnancy complicated with disseminated intravascular coagulation and haemorrhage: a case report. (15875633)
2005
15
Complications of acute fatty liver of pregnancy treated with activated protein C. (16091940)
2005
16
Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy: a case report. (15682663)
2004
17
Maternal acute fatty liver of pregnancy and the associated risk for long-chain 3-hydroxyacyl-coenzyme a dehydrogenase (LCHAD) deficiency in infants. (14988877)
2004
18
Acute fatty liver of pregnancy. (12572598)
2002
19
Acute fatty liver of pregnancy showing microbial infection in the liver. (11197791)
2000
20
Acute fatty liver of pregnancy. (10431960)
1999
21
Acute fatty liver of pregnancy. (9638907)
1998
22
Acute fatty liver of pregnancy in triplet gestation. (9572168)
1998
23
Acute fatty liver of pregnancy. (9592460)
1998
24
Study of the liver changes occurring in preeclampsia and their possible pathogenetic connection with acute fatty liver of pregnancy. (8607495)
1996
25
Acute fatty liver of pregnancy. (8775282)
1996
26
Acute fatty liver of pregnancy. (8885551)
1995
27
Prolonged neuromuscular block associated with acute fatty liver of pregnancy and reduced plasma cholinesterase. (8050430)
1994
28
Transient diabetes insipidus and acute fatty liver of pregnancy. (8018608)
1994
29
Acute fatty liver of pregnancy and long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. (8294091)
1994
30
Acute fatty liver of pregnancy after exposure to toluene. A case report. (8409321)
1993
31
Acute fatty liver of pregnancy. (8331448)
1993
32
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
33
Should routine liver biopsy be done for the definite diagnosis of acute fatty liver of pregnancy? (1878069)
1991
34
Magnetic resonance imaging and computed tomography scan for the diagnosis of acute fatty liver of pregnancy. (2152326)
1990
35
Acute fatty liver of pregnancy. (2204851)
1990
36
Pregnancy-induced hypertension and acute fatty liver of pregnancy: atypical presentations. (2220920)
1990
37
Acute fatty liver of pregnancy. (3233090)
1988
38
Idiopathic acute fatty liver of pregnancy associated with transient diabetes insipidus. Case report. (3828257)
1987
39
Acute fatty liver of pregnancy. (3568646)
1987
40
Acute fatty liver of pregnancy. (3996163)
1985
41
Acute fatty liver of pregnancy: a clinicopathologic study of 35 cases. (2415437)
1985
42
Ultrasonically undetectable fatty liver in acute fatty liver of pregnancy and Reye's syndrome. (3935687)
1985
43
Acute fatty liver of pregnancy. Description of a case of survival. (6713658)
1984
44
Renal morphological changes in idiopathic acute fatty liver of pregnancy. (6384013)
1984
45
Acute fatty liver of pregnancy--survival despite associated severe preeclampsia, coma and coagulopathy. (6578776)
1983
46
Acute fatty liver of pregnancy. (6821781)
1983
47
Idiopathic acute fatty liver of pregnancy. Death from extrahepatic manifestations. (4536859)
1972
48
A case of acute fatty liver of pregnancy. (5427296)
1970
49
Idiopathic acute fatty liver of pregnancy. (5485832)
1970
50
Acute fatty liver of pregnancy. (5677284)
1968

Variations for Acute Fatty Liver of Pregnancy

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Sources:
65UniProtKB/Swiss-Prot, 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Acute Fatty Liver of Pregnancy:

65
id Symbol AA change Variation ID SNP ID
1HADHAp.Glu510GlnVAR_002273rs137852769
2HADHAp.Glu510GlnVAR_002273rs137852769
3HADHAp.Leu342ProVAR_021127

Expression for genes affiliated with Acute Fatty Liver of Pregnancy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Fatty Liver of Pregnancy

Search GEO for disease gene expression data for Acute Fatty Liver of Pregnancy.

Pathways for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.5F3, SERPINC1, F2
2
Show member pathways
8.5F2, SERPINC1, F3
3
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.5F3, SERPINC1, F2
4
Show member pathways
8.5F3, SERPINC1, F2

Compounds for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1aprosulate469.6F2, F3
2napsagatran469.6F2, F3
3brodifacoum469.6F2, F3
4mnpt469.6F2, F3
5appt469.5F2, F3
6hemochron469.5F2, F3
7celite469.3SERPINC1, F3
8reviparin469.2SERPINC1, F3
9heparin sodium469.0F2, F3
10efegatran469.0SERPINC1, F3
11certoparin469.0F3, SERPINC1, F2
12inogatran469.0F2, SERPINC1, F3
13ecarin469.0F3, SERPINC1, F2
14polybrene469.0F2, SERPINC1, F3
15spectrozyme469.0F2, SERPINC1, F3
16danaparoid468.9F2, SERPINC1, F3
17hepaplastin468.9F2, SERPINC1, F3
18rivaroxaban46 129.9F2, SERPINC1, F3
19ximelagatran46 129.9F2, SERPINC1, F3
20organon468.9F2, SERPINC1, F3
21vitamin k146 259.9F2, SERPINC1, F3
22dabigatran52 469.9F3, SERPINC1
23heparinoids468.9F2, SERPINC1, F3
24fondaparinux468.9F3, SERPINC1, F2
25bivalirudin46 129.9F2, SERPINC1, F3
26phenprocoumon46 52 1210.9F2, SERPINC1, F3
27hydroxyethyl starch468.9F2, SERPINC1, F3
28argatroban46 129.9F2, SERPINC1, F3
29ppack468.9F2, SERPINC1, F3
30tranexamic acid46 129.9F2, SERPINC1, F3
31protamine sulfate468.9F2, SERPINC1, F3
32tirofiban46 129.9F2, SERPINC1, F3
33epsilon aminocaproic acid468.9F3, SERPINC1, F2
34ristocetin468.9F2, SERPINC1, F3
35levonorgestrel46 62 30 1211.9F3, SERPINC1, F2
36abciximab46 129.9F2, SERPINC1, F3
37desmopressin46 62 30 1211.9F2, SERPINC1, F3
38coumarin46 3 52 2511.9F2, SERPINC1, F3
39clopidogrel46 52 25 1211.8F3, SERPINC1, F2
40hirudin468.8F2, SERPINC1, F3
41protamine468.8F3, SERPINC1, F2
42dermatan sulfate468.8F3, SERPINC1, F2
43warfarin46 52 25 1211.8F2, SERPINC1, F3
44kininogen468.7F3, SERPINC1, F2
45aprotinin46 129.5F3, SERPINC1, F2
46aspirin46 52 30 2511.4F2, HADHA, SERPINC1, F3
47creatinine468.2F3, SERPINC1, HADHA, F2
48citrate468.0CDKN3, F3, SERPINC1, HADHA, F2
49alanine467.9CDKN3, F3, SERPINC1, HADHA, F2
50serine467.6F2, HADHA, SERPINC1, F3, CDKN3

GO Terms for genes affiliated with Acute Fatty Liver of Pregnancy

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17Gene Ontology
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Cellular components related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.8SERPINC1, F2
2extracellular spaceGO:0056158.5F3, SERPINC1, F2

Biological processes related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075968.5F3, SERPINC1, F2

Molecular functions related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.7F3, SERPINC1
2protein bindingGO:0055157.5CDKN3, F3, SERPINC1, HADHA, F2

Products for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources for Acute Fatty Liver of Pregnancy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet