AFLP
MCID: ACT099
MIFTS: 50

Acute Fatty Liver of Pregnancy (AFLP) malady

Genetic diseases, Rare diseases, Liver diseases, Reproductive diseases categories
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Summaries for Acute Fatty Liver of Pregnancy

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NIH Rare Diseases:42 Acute fatty liver of pregnancy (aflp) is a rare and serious complication of pregnancy. it is characterized by a build-up of fat in the liver, which can lead to liver damage. the cause of aflp is not well understood, but genetics may play a role. symptoms generally begin in the third trimester and may include persistent nausea and vomiting, pain in the stomach or upper-right abdomen, malaise, jaundice and headache. without prompt treatment, aflp can lead to coma, organ failure or death of the mother and baby. treatment involves stabilizing the mother and delivery of the baby.  last updated: 8/25/2014

MalaCards based summary: Acute Fatty Liver of Pregnancy, also known as AFLP, is related to hellp syndrome and disseminated intravascular coagulation. An important gene associated with Acute Fatty Liver of Pregnancy is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Hemostasis and Collagen biosynthesis and modifying enzymes. The compounds aprosulate and napsagatran have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related mouse phenotypes are cardiovascular system and embryogenesis.

Wikipedia:65 Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the... more...

Description from OMIM:46 609016

Aliases & Classifications for Acute Fatty Liver of Pregnancy

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 46OMIM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Acute Fatty Liver of Pregnancy, Aliases & Descriptions:

Name: Acute Fatty Liver of Pregnancy 42 48 62
Aflp 42 48
 
Fatty Liver, Acute, of Pregnancy 46
Acute Fatty Liver, Gestational 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
acute fatty liver of pregnancy:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


External Ids:

MESH via Orphanet35 C537957
ICD10 via Orphanet26 O26.6
UMLS via Orphanet63 C1455728

Related Diseases for Acute Fatty Liver of Pregnancy

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Diseases related to Acute Fatty Liver of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1hellp syndrome31.0HADHA, SERPINC1
2disseminated intravascular coagulation30.8F2, SERPINC1, F3
3cholestasis30.6F2, HADHA
4thrombocytopenia30.1F2, SERPINC1, F3
5pre-eclampsia29.8F2, HADHA, SERPINC1, F3
6hepatitis10.8
7pancreatitis10.6
8diabetes insipidus10.5
9lchad deficiency10.4
103-hydroxyacyl-coenzyme a dehydrogenase deficiency10.4
11hypersplenism10.4F2
12factor xii deficiency10.4F3
13carotid artery thrombosis10.4F3
14factor viii deficiency10.4F3
15sagittal sinus thrombosis10.3SERPINC1
16sneddon syndrome10.3SERPINC1
17acute liver failure10.3
18hepatitis b10.3
19hypertension10.3
20acute pancreatitis10.3
21intrahepatic cholestasis10.3
22eclampsia10.3
23peripartum cardiomyopathy10.3
24hepatic coma10.3
25metabolic acidosis10.3
26herpes simplex10.3
27panniculitis10.3
28peritonitis10.3
29intrahepatic cholestasis of pregnancy10.3
30mallory-weiss syndrome10.3
31trifunctional protein deficiency10.3
32fatty acid oxidation disorders10.3
333-hydroxyacyl-coa dehydrogenase deficiency10.3
34hepatitis b virus infection10.3
35purpura10.2SERPINC1
36plague10.2
37factor x deficiency10.2F3, F2
38factor v deficiency10.2F2, F3
39vitamin k deficiency hemorrhagic disease10.2F2, F3
40factor xi deficiency10.1F2, F3
41von willebrand's disease10.1F2, F3
42afibrinogenemia10.1F3, F2
43hemophilia b10.1F3, F2
44prothrombin deficiency10.1SERPINC1, F2
45leukopenia10.1F3, F2
46blood protein disease10.1F2, SERPINC1
47portal vein thrombosis10.1F2, SERPINC1
48antithrombin iii deficiency10.1F2, SERPINC1
49connective tissue disease10.0F3, F2
50dysfibrinogenemia10.0F2, SERPINC1

Graphical network of the top 20 diseases related to Acute Fatty Liver of Pregnancy:



Diseases related to acute fatty liver of pregnancy

Symptoms for Acute Fatty Liver of Pregnancy

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Clinical features from OMIM:

609016

Drugs & Therapeutics for Acute Fatty Liver of Pregnancy

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Drug clinical trials:

Search ClinicalTrials for Acute Fatty Liver of Pregnancy

Search NIH Clinical Center for Acute Fatty Liver of Pregnancy

Genetic Tests for Acute Fatty Liver of Pregnancy

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Anatomical Context for Acute Fatty Liver of Pregnancy

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MalaCards organs/tissues related to Acute Fatty Liver of Pregnancy:

32
Liver, Kidney, Testes, Pituitary

Animal Models for Acute Fatty Liver of Pregnancy or affiliated genes

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MGI Mouse Phenotypes related to Acute Fatty Liver of Pregnancy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1F3, SERPINC1, HADHA, F2
2MP:00053807.8F3, SERPINC1, HADHA, F2

Publications for Acute Fatty Liver of Pregnancy

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Articles related to Acute Fatty Liver of Pregnancy:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Acute fatty liver of pregnancy treated with plasma exchange. (25138903)
2014
2
Abnormal liver function tests in the third trimester: a diagnostic dilemma. Acute fatty liver of pregnancy. (24560856)
2014
3
Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet counts. (24428400)
2014
4
Acute fatty liver of pregnancy. (25382919)
2014
5
Acute fatty liver of pregnancy complicating a twin pregnancy. (24700907)
2014
6
Effectiveness of combining plasma exchange with continuous hemodiafiltration on acute Fatty liver of pregnancy complicated by multiple organ dysfunction. (22428588)
2012
7
Therapeutic effects of plasma exchange for the treatment of 39 patients with acute fatty liver of pregnancy. (22642918)
2012
8
Acute Fatty liver of pregnancy. (23181240)
2012
9
Early pancreatic panniculitis associated with HELLP syndrome and acute fatty liver of pregnancy. (21752052)
2011
10
Acute fatty liver of pregnancy. (21766548)
2010
11
Clinical diagnosis and treatment of acute fatty liver of pregnancy: a literature review and 11 new cases. (20666940)
2010
12
Acute fatty liver of pregnancy: a case report of an uncommon disease. (19881179)
2009
13
Acute fatty liver of pregnancy and molecular absorbent recirculating system (MARS)-therapy: a case report. (18609350)
2008
14
Acute fatty liver of pregnancy. (16868757)
2006
15
Acute fatty liver of pregnancy -- an underlying condition for herpes simplex type 2 fulminant hepatitis necessitating liver transplantation. (15871067)
2005
16
The association between acute fatty liver of pregnancy and fatty acid oxidation disorders. (15673650)
2005
17
Acute fatty liver of pregnancy complicated with disseminated intravascular coagulation and haemorrhage: a case report. (15875633)
2005
18
Complications of acute fatty liver of pregnancy treated with activated protein C. (16091940)
2005
19
Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy: a case report. (15682663)
2004
20
Maternal acute fatty liver of pregnancy and the associated risk for long-chain 3-hydroxyacyl-coenzyme a dehydrogenase (LCHAD) deficiency in infants. (14988877)
2004
21
Acute fatty liver of pregnancy. (12572598)
2002
22
Acute fatty liver of pregnancy. (10431960)
1999
23
Acute fatty liver of pregnancy. (9638907)
1998
24
Acute fatty liver of pregnancy in triplet gestation. (9572168)
1998
25
Acute fatty liver of pregnancy. (9592460)
1998
26
Study of the liver changes occurring in preeclampsia and their possible pathogenetic connection with acute fatty liver of pregnancy. (8607495)
1996
27
Acute fatty liver of pregnancy. (8775282)
1996
28
Acute fatty liver of pregnancy. (8885551)
1995
29
Prolonged neuromuscular block associated with acute fatty liver of pregnancy and reduced plasma cholinesterase. (8050430)
1994
30
Transient diabetes insipidus and acute fatty liver of pregnancy. (8018608)
1994
31
Acute fatty liver of pregnancy after exposure to toluene. A case report. (8409321)
1993
32
Acute fatty liver of pregnancy. (8331448)
1993
33
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
34
Should routine liver biopsy be done for the definite diagnosis of acute fatty liver of pregnancy? (1878069)
1991
35
Magnetic resonance imaging and computed tomography scan for the diagnosis of acute fatty liver of pregnancy. (2152326)
1990
36
Acute fatty liver of pregnancy. (2204851)
1990
37
Pregnancy-induced hypertension and acute fatty liver of pregnancy: atypical presentations. (2220920)
1990
38
Acute fatty liver of pregnancy. (3233090)
1988
39
Idiopathic acute fatty liver of pregnancy associated with transient diabetes insipidus. Case report. (3828257)
1987
40
Acute fatty liver of pregnancy. (3996163)
1985
41
Acute fatty liver of pregnancy: a clinicopathologic study of 35 cases. (2415437)
1985
42
Ultrasonically undetectable fatty liver in acute fatty liver of pregnancy and Reye's syndrome. (3935687)
1985
43
Acute fatty liver of pregnancy. Description of a case of survival. (6713658)
1984
44
Renal morphological changes in idiopathic acute fatty liver of pregnancy. (6384013)
1984
45
Acute fatty liver of pregnancy--survival despite associated severe preeclampsia, coma and coagulopathy. (6578776)
1983
46
Acute fatty liver of pregnancy. (6821781)
1983
47
Idiopathic acute fatty liver of pregnancy. Death from extrahepatic manifestations. (4536859)
1972
48
A case of acute fatty liver of pregnancy. (5427296)
1970
49
Idiopathic acute fatty liver of pregnancy. (5485832)
1970
50
Acute fatty liver of pregnancy. (5677284)
1968

Variations for Acute Fatty Liver of Pregnancy

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UniProtKB/Swiss-Prot genetic disease variations for Acute Fatty Liver of Pregnancy:

64
id Symbol AA change Variation ID SNP ID
1HADHAp.Glu510GlnVAR_002273rs137852769
2HADHAp.Glu510GlnVAR_002273rs137852769
3HADHAp.Leu342ProVAR_021127

Expression for genes affiliated with Acute Fatty Liver of Pregnancy

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Expression patterns in normal tissues for genes affiliated with Acute Fatty Liver of Pregnancy

Search GEO for disease gene expression data for Acute Fatty Liver of Pregnancy.

Pathways for genes affiliated with Acute Fatty Liver of Pregnancy

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Pathways related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.5F3, SERPINC1, F2
2
Show member pathways
8.5F2, SERPINC1, F3
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.5F3, SERPINC1, F2
4
Show member pathways
8.5F3, SERPINC1, F2

Compounds for genes affiliated with Acute Fatty Liver of Pregnancy

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Compounds related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1aprosulate449.6F2, F3
2napsagatran449.6F2, F3
3brodifacoum449.6F2, F3
4mnpt449.6F2, F3
5appt449.5F2, F3
6hemochron449.5F2, F3
7celite449.3SERPINC1, F3
8reviparin449.2SERPINC1, F3
9heparin sodium449.0F2, F3
10efegatran449.0SERPINC1, F3
11certoparin449.0F3, SERPINC1, F2
12inogatran449.0F2, SERPINC1, F3
13ecarin449.0F3, SERPINC1, F2
14polybrene449.0F2, SERPINC1, F3
15spectrozyme449.0F2, SERPINC1, F3
16danaparoid448.9F2, SERPINC1, F3
17hepaplastin448.9F2, SERPINC1, F3
18rivaroxaban44 119.9F2, SERPINC1, F3
19ximelagatran44 119.9F2, SERPINC1, F3
20organon448.9F2, SERPINC1, F3
21vitamin k144 249.9F2, SERPINC1, F3
22dabigatran50 449.9F3, SERPINC1
23heparinoids448.9F2, SERPINC1, F3
24fondaparinux448.9F3, SERPINC1, F2
25bivalirudin44 119.9F2, SERPINC1, F3
26phenprocoumon44 50 1110.9F2, SERPINC1, F3
27hydroxyethyl starch448.9F2, SERPINC1, F3
28argatroban44 119.9F2, SERPINC1, F3
29ppack448.9F2, SERPINC1, F3
30tranexamic acid44 119.9F2, SERPINC1, F3
31protamine sulfate448.9F2, SERPINC1, F3
32tirofiban44 119.9F2, SERPINC1, F3
33epsilon aminocaproic acid448.9F3, SERPINC1, F2
34ristocetin448.9F2, SERPINC1, F3
35levonorgestrel44 61 28 1111.9F3, SERPINC1, F2
36abciximab44 119.9F2, SERPINC1, F3
37desmopressin44 61 28 1111.9F2, SERPINC1, F3
38coumarin44 2 50 2411.9F2, SERPINC1, F3
39clopidogrel44 50 24 1111.8F3, SERPINC1, F2
40hirudin448.8F2, SERPINC1, F3
41protamine448.8F3, SERPINC1, F2
42dermatan sulfate448.8F3, SERPINC1, F2
43warfarin44 50 24 1111.8F2, SERPINC1, F3
44kininogen448.7F3, SERPINC1, F2
45aprotinin44 119.5F3, SERPINC1, F2
46aspirin44 50 28 2411.4F2, HADHA, SERPINC1, F3
47creatinine448.2F3, SERPINC1, HADHA, F2
48citrate448.0CDKN3, F3, SERPINC1, HADHA, F2
49alanine447.9CDKN3, F3, SERPINC1, HADHA, F2
50serine447.6F2, HADHA, SERPINC1, F3, CDKN3

GO Terms for genes affiliated with Acute Fatty Liver of Pregnancy

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Cellular components related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.8SERPINC1, F2
2extracellular spaceGO:0056158.5F3, SERPINC1, F2

Biological processes related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075968.5F3, SERPINC1, F2

Molecular functions related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.7F3, SERPINC1
2protein bindingGO:0055157.5CDKN3, F3, SERPINC1, HADHA, F2

Products for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources for Acute Fatty Liver of Pregnancy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet