AFLP
MCID: ACT099
MIFTS: 39

Acute Fatty Liver of Pregnancy (AFLP) malady

Liver diseases, Reproductive diseases categories

Summaries for Acute Fatty Liver of Pregnancy

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the... more...

MalaCards: Acute Fatty Liver of Pregnancy, also known as AFLP, is related to hepatitis and acute liver failure. An important gene associated with Acute Fatty Liver of Pregnancy is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and FOXA2 and FOXA3 transcription factor networks. The compounds warfarin and brodifacoum have been mentioned in the context of this disorder. Affiliated tissues include liver.

Description from OMIM:46 609016

Aliases & Classifications for Acute Fatty Liver of Pregnancy

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases, Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
acute fatty liver of pregnancy:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

acute fatty liver of pregnancy 42 48
aflp 42 48
fatty liver, acute, of pregnancy 46
acute fatty liver, gestational 42


External Ids:

MESH via Orphanet35 C537957
ICD10 via Orphanet26 O26.6
SNOMED-CT via Orphanet57 91162000
UMLS via Orphanet61 C1455728

Related Diseases for Acute Fatty Liver of Pregnancy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Fatty Liver of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0ALB, F2
2acute liver failure31.0ALB, F2
3disseminated intravascular coagulation30.9SERPINC1, F2, F3
4hellp syndrome30.8SERPINC1, HADHA
5pancreatitis30.8ALB
6hepatitis a30.6F2
7eclampsia30.3SERPINC1
8peritonitis30.3F2, ALB
9hypertension30.3ALB, F2
10hepatitis b30.3ALB, F2
11cholestasis30.3ALB, F2, HADHA
12pre-eclampsia30.3SERPINC1, F2, F3, HADHA
13thrombocytopenia30.3ALB, SERPINC1, F2, F3
14cystic fibrosis29.9ALB, CDKN3, HADHA
15acute pancreatitis10.5
16fatty liver disease10.5
17diabetes insipidus10.5
18liver disease10.5
19intrahepatic cholestasis10.2
20peripartum cardiomyopathy10.2
21metabolic acidosis10.2
22hepatic coma10.2
23herpes simplex10.2
24panniculitis10.2
25plague10.1
26chikungunya10.0
27leishmaniasis10.0
28pancreatic cancer10.0
29viral hepatitis10.0F2
30peripheral vascular disease10.0ALB
31ovarian hyperstimulation syndrome10.0ALB
32purpura fulminans10.0SERPINC1
33essential hypertension10.0ALB
34acquired immunodeficiency syndrome10.0ALB
35short bowel syndrome10.0ALB
36retinal vein occlusion10.0SERPINC1
37purpura10.0SERPINC1
38hypersplenism10.0F2
39lung cancer10.0ALB
40sagittal sinus thrombosis10.0SERPINC1
41uremia10.0ALB
42cholangitis10.0ALB
43sneddon syndrome10.0SERPINC1
44maple syrup urine disease10.0HADHA
45primary hyperoxaluria10.0SERPINC1
46factor xii deficiency10.0F3
47intracranial hypertension10.0ALB
48carotid artery thrombosis10.0F3
49hemarthrosis10.0F3
50factor viii deficiency10.0F3

Graphical network of the top 20 diseases related to Acute Fatty Liver of Pregnancy:



Diseases related to acute fatty liver of pregnancy

Clinical Features for Acute Fatty Liver of Pregnancy

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Sources:
46OMIM
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Clinical features from OMIM:

609016

Drugs & Therapeutics for Acute Fatty Liver of Pregnancy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Fatty Liver of Pregnancy

Drug clinical trials:

Search ClinicalTrials for Acute Fatty Liver of Pregnancy

Search NIH Clinical Center for Acute Fatty Liver of Pregnancy

Search CenterWatch for Acute Fatty Liver of Pregnancy

Genetic Tests for Acute Fatty Liver of Pregnancy

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Anatomical Context for Acute Fatty Liver of Pregnancy

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acute Fatty Liver of Pregnancy:

32
Liver

Animal Models for Acute Fatty Liver of Pregnancy or affiliated genes

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Publications for Acute Fatty Liver of Pregnancy

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Genetic Variations for Acute Fatty Liver of Pregnancy

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Fatty Liver of Pregnancy:

62
id Symbol AA change Variation ID SNP ID
1HADHAp.Glu510GlnVAR_002273rs137852769
2HADHAp.Glu510GlnVAR_002273rs137852769
3HADHAp.Leu342ProVAR_021127

Expression for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Fatty Liver of Pregnancy

Search GEO for disease gene expression data for Acute Fatty Liver of Pregnancy.

Pathways for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.4SERPINC1
2brodifacoum4410.1F3
3aprosulate4410.1F3
4napsagatran449.6F2, F3
5celite449.5F3, SERPINC1
6appt449.4F3, F2
7reviparin449.3F3, SERPINC1
8certoparin449.3F3, SERPINC1, F2
9inogatran449.3F3, F2, SERPINC1
10ecarin449.3F3, F2, SERPINC1
11hextend449.3SERPINC1, ALB
12spectrozyme449.3F3, SERPINC1, F2
13polybrene449.3F2, F3, SERPINC1
14danaparoid449.3SERPINC1, F2, F3
15hemochron449.3F3, F2
16organon449.3F2, SERPINC1, F3
17ximelagatran44 1110.3SERPINC1, F2, F3
18rivaroxaban44 1110.3SERPINC1, F3, F2
19vitamin k144 2410.3F3, F2, SERPINC1
20heparinoids449.3F3, F2, SERPINC1
21fondaparinux449.3F3, F2, SERPINC1
22bivalirudin44 1110.3F3, F2, SERPINC1
23argatroban44 1110.3F3, F2, SERPINC1
24ppack449.3F3, SERPINC1, F2
25protamine sulfate449.2F3, SERPINC1, F2
26tranexamic acid44 1110.2F2, F3, SERPINC1
27tirofiban44 1110.2F2, F3, SERPINC1
28epsilon aminocaproic acid449.2F3, F2, SERPINC1
29ristocetin449.2F3, SERPINC1, F2
30levonorgestrel44 59 28 1112.2F2, F3, SERPINC1
31abciximab44 1110.2SERPINC1, F3, F2
32clopidogrel49 44 11 2412.2F3, F2, SERPINC1
33coumarin44 2 49 2412.2F3, F2, SERPINC1
34desmopressin44 59 28 1112.2F3, F2, SERPINC1
35hirudin449.1F2, SERPINC1, F3
36dabigatran449.0SERPINC1, F3
37protamine449.0SERPINC1, F2, F3
38dextran 70449.0ALB, F2, F3
39dermatan sulfate449.0F3, SERPINC1, F2
40acenocoumarol44 49 1111.0F3, F2, ALB
41aspirin44 49 28 2411.8SERPINC1, HADHA, F2, F3
42hepaplastin448.5F3, F2, SERPINC1, ALB
43phenprocoumon44 49 1110.5ALB, SERPINC1, F2, F3
44hydroxyethyl starch448.5F3, F2, SERPINC1, ALB
45kininogen448.5ALB, F3, SERPINC1, F2
46homocysteine44 249.4F2, ALB, SERPINC1, F3
47fibrinogen448.1ALB, SERPINC1, F2, F3
48creatinine448.0SERPINC1, ALB, F2, F3, HADHA
49citrate447.6HADHA, CDKN3, F3, F2, SERPINC1, ALB
50alanine447.5ALB, SERPINC1, F2, F3, CDKN3, HADHA

GO Terms for genes affiliated with Acute Fatty Liver of Pregnancy

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Sources:
16Gene Ontology
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Cellular components related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1ALB, SERPINC1, F2, F3

Biological processes related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.1ALB, SERPINC1
2blood coagulationGO:0075967.8ALB, SERPINC1, F2, F3

Molecular functions related to Acute Fatty Liver of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3SERPINC1, F3
2protein bindingGO:0055156.8ALB, SERPINC1, F2, F3, CDKN3, HADHA

Products for genes affiliated with Acute Fatty Liver of Pregnancy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Fatty Liver of Pregnancy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet