MCID: ACT167
MIFTS: 40

Acute Generalized Exanthematous Pustulosis malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 53 67
Agep 53 67
 
Pustular Drug Eruption 53
Toxic Pustuloderma 53

Characteristics:

Orphanet epidemiological data:

53
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy

Classifications:

Orphanet: 53 
Rare skin diseases


External Ids:

Orphanet53 ORPHA293173
UMLS via Orphanet68 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:70 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and psoriasis, and has symptoms including exanthema, pruritus and skin manifestations. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways are Rheumatoid arthritis and IL-17 Family Signaling Pathways. Affiliated tissues include skin, testes and neutrophil.

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.7CXCL8, IL17A, PTGS2
2psoriasis10.5
3pustular psoriasis10.4
4biliary tract disease10.3CXCL8, IL17A
5burn scar10.3CXCL8, IL17A
6chronic endophthalmitis10.3CXCL8, IL17A
7blind hypotensive eye10.3CXCL8, IL17A
8pyruvate kinase deficiency, liver type10.3IL17A, IL36RN
9lung sarcoma10.2CXCL8, IL17A
10rectum leiomyosarcoma10.2CXCL8, IL17A
11benign renovascular hypertension10.2CXCL8, IL17A
12uterine corpus endometrial stromal sarcoma10.2CXCL8, IL36RN
13laryngeal tuberculosis10.2CXCL8, IL17A
14foveal hypoplasia 110.2CXCL8, IL17A
15eosinophilic gastroenteritis10.2CXCL8, IL17F
16palmoplantar keratosis10.1CXCL8, IL17A
17personality disorder10.1IL17A, IL17F
18gingivitis10.1CXCL8, IL17A
19basaloid squamous cell carcinoma10.1CXCL8, IL17A
20leukemia10.1
21ulcerative colitis10.1
22colitis10.1
23dermatitis10.1
24contact dermatitis10.1
25allergic contact dermatitis10.1
26pancreatitis10.1
27pneumonia10.1
28myeloid leukemia10.1
29eosinophilia10.1
30microscopic colitis10.0CXCL8, IL17A
31benign fibrous mesothelioma9.9CXCL8, PTGS2
32tibialis tendinitis9.9CXCL8, PTGS2
33intracortical osteogenic sarcoma9.9CXCL8, PTGS2
34pediatric supratentorial ependymoma9.9CXCL8, PTGS2
35synostosis9.9CXCL8, PTGS2
36lung cancer9.9
37leprosy9.9
38multiple myeloma9.9
39pancreatic cancer9.9
40hailey-hailey disease9.9
41arthritis9.9
42glomerulonephritis9.9
43hemolytic anemia9.9
44hepatitis9.9
45osteonecrosis9.9
46erythema multiforme9.9
47mumps9.9
48optic neuritis9.9
49cystic echinococcosis9.9
50echinococcosis9.9

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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UMLS symptoms related to Acute Generalized Exanthematous Pustulosis:


exanthema, pruritus, skin manifestations, pustular rash, application site pustules, mucosal toxicity

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Saxagliptinapproved126361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
 
BMS-477118
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
2
Eslicarbazepine acetateapproved6375970-99-9, 236395-14-5123618
Synonyms:
(10S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
(10S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate
10-Acetoxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
236395-14-5
AC1L452K
AKOS005145781
B5435_SIGMA
BIA 2-093
BIA-2-093
CHEBI:239940
CHEMBL87992
CID179344
 
ESL
Erelib
Eslicarbazepine acetate
Exalief
MolPort-005-942-413
NCGC00165752-01
NCGC00165752-02
Pazzul
S-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
SEP-0002093
Stedesa
ZINC00007295
Zebinix
[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate
3Incretins1537
4Dipeptidyl-Peptidase IV Inhibitors846
5
protease inhibitors5320
Synonyms:
 
protease inhibitors
6Hypoglycemic Agents5733
7HIV Protease Inhibitors5319
8Hormones, Hormone Substitutes, and Hormone Antagonists12767
9Hormone Antagonists12778
10Hormones13979
11Sodium Channel Blockers1515
12Diuretics, Potassium Sparing1827

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsCompletedNCT01086319
2Severe Cutaneous Adverse Reactions in ThailandRecruitingNCT02574988
3An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine AcetateRecruitingNCT02520557
4Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

35
Skin, Testes, Neutrophil, T cells, Myeloid, Liver, Lung

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. (27025295)
2016
2
Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy. (27334410)
2016
3
Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly. (27354743)
2016
4
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
5
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis: a coincidence? (25677856)
2015
6
Acute Generalized Exanthematous Pustulosis Caused by Faropenem: A Possible Pathogenetic Role for Interleukin-23. (26302837)
2015
7
Acute generalized exanthematous pustulosis induced by celecoxib. (26488335)
2015
8
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
9
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
10
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
11
Acute generalized exanthematous pustulosis as a side effect of quetiapine. (23470612)
2013
12
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
13
Acute generalized exanthematous pustulosis caused by methimazole. (22575903)
2012
14
Acute Generalized Exanthematous Pustulosis Induced by Erlotinib (Tarceva) with Superimposed Staphylococcus aureus Skin Infection in a Pancreatic Cancer Patient: A Case Report. (22712013)
2012
15
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
16
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
17
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
18
Carbamazepine-induced acute generalized exanthematous pustulosis: a case report. (22477826)
2011
19
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
20
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
21
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
22
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
23
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
24
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
25
A severe case of acute generalized exanthematous pustulosis (AGEP) in a child after the administration of amoxicillin-clavulanic acid: brief report. (19840330)
2009
26
Etanercept in the treatment of a patient with acute generalized exanthematous pustulosis/toxic epidermal necrolysis: definition of a new model based on translational research. (19659879)
2009
27
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
28
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
29
Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drug-related case. (18598307)
2008
30
Acute generalized exanthematous pustulosis possibly induced by acarbose. (19126027)
2008
31
Acute generalized exanthematous pustulosis induced by bufexamac in an atopic girl. (18353041)
2008
32
Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia. (18709306)
2008
33
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
34
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
35
Food-induced acute generalized exanthematous pustulosis in a pregnant woman. (16855416)
2006
36
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
37
Ciprofloxacin-induced acute generalized exanthematous pustulosis mimicking bullous drug eruption confirmed by a positive patch test. (16205075)
2005
38
Acute generalized exanthematous pustulosis in pregnancy: more common than previously estimated. (16419338)
2005
39
Acute generalized exanthematous pustulosis induced by topical lindane. (15459542)
2004
40
Acute generalized exanthematous pustulosis in a six-year-old boy. (15235193)
2004
41
Acute generalized exanthematous pustulosis due to sulfamethoxazol with positive lymphocyte transformation test (LTT). (12861854)
2003
42
Metamizole-induced acute generalized exanthematous pustulosis. (14641128)
2003
43
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
44
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
45
Acute generalized exanthematous pustulosis induced by oral fluconazole. (11992184)
2002
46
Acute generalized exanthematous pustulosis with erythema multiforme-like lesions. (12370139)
2002
47
Acute generalized exanthematous pustulosis (AGEP)--a clinical reaction pattern. (11168761)
2001
48
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
49
Acute generalized exanthematous pustulosis. (9069592)
1996
50
Acute generalized exanthematous pustulosis due to doxycycline. (8435524)
1993

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.6CXCL8, IL17A
2
Show member pathways
9.5IL17A, IL17F
39.4IL17A, IL22
49.2CXCL8, PTGS2
5
Show member pathways
9.2CXCL8, PTGS2
69.2CXCL8, PTGS2
7
Show member pathways
9.0CXCL8, IL17A, IL22
89.0CXCL8, IL17A, IL22
9
Show member pathways
8.9IL17A, IL17F, IL22
10
Show member pathways
8.9IL17A, IL17F, IL22
11
Show member pathways
8.7CXCL8, IL36RN, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.2CXCL8, IL17A, IL17F, IL22
2extracellular spaceGO:00056157.9CXCL8, IL17A, IL17F, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 secretionGO:200077810.2IL17A, IL17F
2positive regulation of cytokine production involved in inflammatory responseGO:190001710.1IL17A, IL17F
3cellular response to interleukin-1GO:00713479.9CXCL8, IL17A
4response to glucocorticoidGO:00513849.5IL22, PTGS2
5movement of cell or subcellular componentGO:00069289.2CXCL8, PTGS2
6immune responseGO:00069558.7CXCL8, IL17A, IL22
7inflammatory responseGO:00069547.6CXCL8, IL17A, IL17F, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:000512610.1IL17A, IL17F
2cytokine activityGO:00051258.4IL17A, IL17F, IL22, IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet