MCID: ACT167
MIFTS: 35

Acute Generalized Exanthematous Pustulosis malady

Skin diseases, Rare diseases categories

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
51Orphanet, 65UMLS, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 51 65
Agep 51 65
 
Pustular Drug Eruption 51
Toxic Pustuloderma 51


Classifications:

Orphanet: 51 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

51
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet51 293173
UMLS via Orphanet66 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:68 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and psoriasis. An important gene associated with Acute Generalized Exanthematous Pustulosis is PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase And Cyclooxygenase)), and among its related pathways are NF-kappa B signaling pathway and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are digestive/alimentary and respiratory system.

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis30.1CXCL8, IL17A, PTGS2
2psoriasis10.9
3pustular psoriasis10.9
4leukemia10.5
5ulcerative colitis10.5
6allergic contact dermatitis10.5
7colitis10.5
8contact dermatitis10.5
9dermatitis10.5
10myeloid leukemia10.5
11pancreatitis10.5
12pneumonia10.5
13lung cancer10.4
14leprosy10.4
15multiple myeloma10.4
16pancreatic cancer10.4
17arthritis10.4
18glomerulonephritis10.4
19hemolytic anemia10.4
20cystic echinococcosis10.4
21acute pancreatitis10.4
22mumps10.4
23lymphangitis10.4
24polyarteritis nodosa10.4
25hypoglycemia10.4
26erythema multiforme10.4
27echinococcosis10.4
28eosinophilia10.4
29myeloma10.4
30neuritis10.4
31optic neuritis10.4
32cytomegalovirus infection10.4
33drug rash with eosinophilia and systemic symptoms10.4
34h. pylori infection10.1CXCL8, PTGS2
35sebaceous adenoma10.1CXCL8, PTGS2
36vulvovaginal candidiasis10.1CXCL8, PTGS2
37stomatitis10.1CXCL8, PTGS2
38extraosseous ewings sarcoma-primitive neuroepithelial tumor10.1CXCL8, PTGS2
39juvenile type testicular granulosa cell tumor10.1CXCL8, PTGS2
40periapical periodontitis10.1CXCL8, PTGS2
41vasculitis10.1
42gastroesophageal reflux10.1CXCL8, PTGS2
43esophagus adenocarcinoma10.1CXCL8, PTGS2
44dacryoadenitis10.0CXCL8, PTGS2
45bronchopulmonary dysplasia10.0CXCL8, IL17A
46conventional central osteosarcoma10.0CXCL8, IL17A
47capillary disease10.0IL17A, IL17F
48keratitis10.0CXCL8, IL17A
49gastroenteritis10.0CXCL8, PTGS2
50endometriosis of uterus10.0CXCL8, PTGS2

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Saxagliptinapproved116361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
BMS-477118
 
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
Saxagliptin Hydrochloride
2
Eslicarbazepine acetate6175970-99-9123618
Synonyms:
10-Acetoxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
236395-14-5
AC1L452K
AKOS005145781
B5435_SIGMA
BIA 2-093
BIA-2-093
CHEBI:239940
CHEMBL87992
CID179344
Erelib
 
Eslicarbazepine acetate
Exalief
MolPort-005-942-413
NCGC00165752-01
NCGC00165752-02
Pazzul
S-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
SEP-0002093
Stedesa
ZINC00007295
Zebinix
[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsCompletedNCT01086319
2Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275
3Severe Cutaneous Adverse Reactions in ThailandRecruitingNCT02574988
4An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine AcetateRecruitingNCT02520557

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

33
Testes, Skin, T cells, Myeloid, Neutrophil, Liver, Lung

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6IL17A, IL17F, IL22, PTGS2
2MP:00053888.4IL17A, IL17F, IL22, PTGS2
3MP:00053977.1CXCL8, IL17A, IL17F, IL22, IL36RN, PTGS2
4MP:00053876.8CXCL8, IL17A, IL17F, IL22, IL36RN, PTGS2

Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 304)
idTitleAuthorsYear
1
Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. (26561525)
2015
2
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
3
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. (24888401)
2014
4
Pancreatitis-associated with riluzole; linezolid-induced hypoglycemia; sorafenib-induced acute generalized exanthematous pustulosis; creatine supplementation-induced thrombotic events; acute pancreatitis associated with quetiapine; hypomagnesemia and seizure associated with rabeprazole. (25673887)
2014
5
Acute generalized exanthematous pustulosis associated with tigecycline. (24882982)
2014
6
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
7
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
8
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
9
Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection. (24986490)
2014
10
Midodrine-induced acute generalized exanthematous pustulosis. (24897147)
2014
11
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
12
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
13
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
14
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
15
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
16
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
17
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
18
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
19
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
20
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
21
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
22
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
23
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
24
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
25
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
26
Acute generalized exanthematous pustulosis in a patient after stem cell transplantation. (20642988)
2010
27
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
28
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
29
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
30
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
31
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
32
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
33
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
34
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
35
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
36
Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. (19123438)
2008
37
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
38
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
39
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
40
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
41
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
42
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
43
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
44
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
45
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
46
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
47
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
48
Acute generalized exanthematous pustulosis due to teicoplanin. (11306839)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CXCL8, PTGS2
29.5CXCL8, PTGS2
3
Show member pathways
9.5CXCL8, PTGS2
4
Show member pathways
9.5IL17A, IL17F
59.4CXCL8, IL17A
6
Show member pathways
9.0CXCL8, IL17A, IL17F
7
Show member pathways
8.9IL17A, IL17F, IL22
8
Show member pathways
8.9IL17A, IL17F, IL22
9
Show member pathways
8.7CXCL8, IL36RN, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1CXCL8, IL17A, IL17F, IL22
2extracellular spaceGO:00056157.5CXCL8, IL17A, IL17F, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine production involved in inflammatory responseGO:190001710.1IL17A, IL17F
2response to glucocorticoidGO:00513849.7IL22, PTGS2
3movement of cell or subcellular componentGO:00069289.5CXCL8, PTGS2
4cellular response to interleukin-1GO:00713479.5CXCL8, IL17A
5inflammatory responseGO:00069547.6CXCL8, IL17A, IL17F, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:00051269.9IL17A, IL17F
2cytokine activityGO:00051258.1IL17A, IL17F, IL22, IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet