MCID: ACT167
MIFTS: 35

Acute Generalized Exanthematous Pustulosis malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
51Orphanet, 65UMLS, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 51 65
Agep 51 65
 
Pustular Drug Eruption 51
Toxic Pustuloderma 51

Characteristics:

Orphanet epidemiological data:

51
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Orphanet51 293173
UMLS via Orphanet66 C0877055
UMLS65 C0877055, C0863129

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:68 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and breast cancer. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways are Rheumatoid arthritis and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include skin, liver and neutrophil.

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Saxagliptinapproved120361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
BMS-477118
 
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
Saxagliptin Hydrochloride
2Incretins1326
3Protease Inhibitors4558
4Dipeptidyl-Peptidase IV Inhibitors779
5Hypoglycemic Agents4503
6Hormones, Hormone Substitutes, and Hormone Antagonists9988
7Hormone Antagonists10002
8HIV Protease Inhibitors4558
9Hormones11748
10Sodium Channel Blockers1180
11Diuretics, Potassium Sparing1445
12
Eslicarbazepine acetate6275970-99-9123618
Synonyms:
10-Acetoxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
236395-14-5
AC1L452K
AKOS005145781
B5435_SIGMA
BIA 2-093
BIA-2-093
CHEBI:239940
CHEMBL87992
CID179344
Erelib
 
Eslicarbazepine acetate
Exalief
MolPort-005-942-413
NCGC00165752-01
NCGC00165752-02
Pazzul
S-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
SEP-0002093
Stedesa
ZINC00007295
Zebinix
[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsCompletedNCT01086319
2Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275
3Severe Cutaneous Adverse Reactions in ThailandRecruitingNCT02574988
4An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine AcetateRecruitingNCT02520557

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

33
Skin, Liver, Neutrophil, T cells, Endothelial, Monocytes, Bone

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 306)
idTitleAuthorsYear
1
A rare case of cryptogenic stroke with an incidental finding of patent foramen ovale. (25876305)
2015
2
Plasma levels of apolipoprotein E and risk of dementia in the general population. (25469919)
2015
3
A rare case report of mucinous cystadenoma with immunohistochemical analysis and review of literature. (25861198)
2015
4
Chronic urticaria: new management options. (25383135)
2014
5
Electrocardiographic manifestations in acute methanol poisoning. (25470191)
2014
6
Suppressing AP1 Factor Signaling in the Suprabasal Epidermis Produces a Keratoderma Phenotype. (25050598)
2014
7
Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy. (23742804)
2013
8
Littoral-cell angioma of the spleen. (23432174)
2013
9
Diagnostic value of three-dimensional magnetic resonance imaging of inner ear after intratympanic gadolinium injection, and clinical application of magnetic resonance imaging scoring system in patients with delayed endolymphatic hydrops. (24355544)
2013
10
EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) ON BLOOD PRESSURE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA/HYPOPNEA. A SYSTEMATIC REVIEW AND META-ANALYSIS. (24077181)
2013
11
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. (22829597)
2012
12
Seroprevalance of brucellosis among suspected cases in Malaysia. (21874749)
2011
13
Fine mapping of the NRG1 Hirschsprung's disease locus. (21283760)
2011
14
Peripheral T-cell lymphoma. (21493798)
2011
15
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation. (21300904)
2011
16
Genome-wide methylation analysis identifies involvement of TNF-I+ mediated cancer pathways in prostate cancer. (21237555)
2011
17
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. (19955654)
2010
18
Descending necrotizing mediastinitis: minimally invasive thoracic surgical treatment. (21225185)
2010
19
Dimethylsulfoxide-induced expression of thymic stromal lymphopoietin in human bronchial epithelial cells]. (20501368)
2010
20
Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. (18802403)
2008
21
Clinical symptoms and histopathological findings in subjects with adenomyosis uteri. (18390081)
2008
22
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. (19088846)
2008
23
Avascular necrosis of the femoral head in sickle cell disease in Nigeria: a retrospective study. (17767206)
2007
24
Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. (17293559)
2007
25
TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. (16500080)
2006
26
Enzymatic diagnostics in obstetrics and gynecology. Part I]. (16171146)
2005
27
Trk is a calmodulin-binding protein: implications for receptor processing. (14690530)
2004
28
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
29
In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4. (15480536)
2004
30
Urinalysis for interleukin-8 in the non-invasive diagnosis of acute and chronic inflammatory diseases. (12697917)
2003
31
Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. (12106685)
2002
32
Sphincter of Oddi dysfunction: pancreaticobiliary sphincterotomy with pancreatic stent placement has a lower rate of pancreatitis than biliary sphincterotomy alone. (11932782)
2002
33
Aerosolized protein delivery in asthma: gamma camera analysis of regional deposition and perfusion. (11681650)
2001
34
Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide. (10627291)
2000
35
Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats. (11003996)
2000
36
Initial results from uterine fibroid embolization for symptomatic leiomyomata. (10527190)
1999
37
Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. (10545739)
1999
38
Plasma lactate concentration as a predictor of gastric necrosis and survival among dogs with gastric dilatation-volvulus: 102 cases (1995-1998). (10397065)
1999
39
Inflammation markers in nasal lavage, and nasal symptoms in relation to relocation to a newly painted building: a longitudinal study. (10592002)
1999
40
Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9. (10556578)
1999
41
Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure: their relation to lesion site and beta-adrenergic receptor therapy. (9679719)
1998
42
Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period. (9194923)
1997
43
Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma. (8621139)
1996
44
Angiogenic factors in moyamoya disease. (8969773)
1996
45
ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. (2188736)
1990
46
Elevated serum IgA associated with immunoproliferative enteropathy of Basenji dogs: lack of evidence for alpha heavy-chain disease or enhanced intestinal IgA secretion. (3149068)
1988
47
Reactivation of infectious bovine rhinotracheitis virus by transport. (3034502)
1987
48
The craniotubular bone modeling disorders: a neurosurgical introduction to rare skeletal dysplasias with cranial nerve compression. (847638)
1977
49
Desmoid tumor. (21019323)
1946
50
Granulosa-cell tumor of the ovary. (21001409)
1946

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6CXCL8, IL17A
29.4IL17A, IL22
39.2CXCL8, PTGS2
49.2CXCL8, PTGS2
5
Show member pathways
9.2CXCL8, PTGS2
6
Show member pathways
9.1CXCL8, IL17A, IL17F
7
Show member pathways
8.9IL17A, IL17F, IL22
8
Show member pathways
8.9IL17A, IL17F, IL22
9
Show member pathways
8.7CXCL8, IL36RN, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 secretionGO:200077810.0IL17A, IL17F
2positive regulation of cytokine production involved in inflammatory responseGO:19000179.6IL17A, IL17F
3movement of cell or subcellular componentGO:00069289.2CXCL8, PTGS2
4response to glucocorticoidGO:00513848.9IL22, PTGS2

Sources for Acute Generalized Exanthematous Pustulosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet