AGEP
MCID: ACT167
MIFTS: 45

Acute Generalized Exanthematous Pustulosis (AGEP) malady

Skin diseases, Rare diseases categories

Summaries for Acute Generalized Exanthematous Pustulosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards: Acute Generalized Exanthematous Pustulosis, also known as AGEP, is related to ulcerative colitis and sepsis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (interleukin 36 receptor antagonist), and among its related pathways are Toll Comparative Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The compounds nonoxynol-9 and triptolide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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50Orphanet, 63UMLS, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 50 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

50
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acute generalized exanthematous pustulosis 50 63
agep 50 63
pustular drug eruption 50
toxic pustuloderma 50


External Ids:

UMLS via Orphanet64 C0877055

Related Diseases for Acute Generalized Exanthematous Pustulosis

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18GeneCards, 19GeneDecks
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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.7IL22, IL8
2sepsis30.5ALB, IL8
3pneumonia30.5IL22, IL8
4arthritis30.5ALB, IL8, PTGS2
5lung cancer30.5ALB, PTGS2
6rheumatoid arthritis30.5IL8, IL22, PTGS2
7toxic epidermal necrolysis10.9
8psoriasis10.8
9chronic myeloid leukemia10.5
10stevens-johnson syndrome10.5
11allergic contact dermatitis10.5
12contact dermatitis10.5
13dermatitis10.5
14leukemia10.5
15myeloid leukemia10.5
16generalized pustular psoriasis10.5
17cystic echinococcosis10.4
18lymphangitis10.4
19erythema multiforme10.4
20echinococcosis10.4
21encephalomyelitis10.4
22eosinophilia10.4
23glomerulonephritis10.4
24hemolytic anemia10.4
25leprosy10.4
26multiple myeloma10.4
27myeloma10.4
28neuritis10.4
29optic neuritis10.4
30pancreatic cancer10.4
31pancreatitis10.4
32cytomegalovirus infection10.4
33drug rash with eosinophilia and systemic symptoms10.4
34common cold10.1IL8
35bronchiolitis10.1IL8
36vascular disease10.0IL8, PTGS2
37peptic ulcer disease10.0IL8, PTGS2
38alcoholic hepatitis10.0IL8, ALB
39mastitis10.0ALB, IL8
40gastritis10.0PTGS2, IL8
41alcoholic liver cirrhosis10.0IL8, ALB
42rhinitis10.0IL8, ALB
43endometriosis10.0PTGS2, IL8
44meningitis10.0IL8, ALB
45cork-handlers' disease10.0ALB, IL8
46squamous cell carcinoma of the head and neck10.0IL8, PTGS2
47skin disease10.0IL8, IL22
48atherosclerosis10.0ALB, IL8, PTGS2
49galactosemia10.0IL22, ALB
50inflammatory bowel disease10.0PTGS2, IL8, IL22

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Generalized Exanthematous Pustulosis

Drug clinical trials:

Search ClinicalTrials for Acute Generalized Exanthematous Pustulosis

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Search CenterWatch for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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34MalaCards
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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

34
Testes, Skin, T cells, Myeloid, Liver, Lung

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, IL22, PTGS2
2MP:00053708.4ALB, IL22, PTGS2
3MP:00053978.3IL8, IL22, IL36RN, PTGS2
4MP:00053818.2PTGS2, IL22, ALB
5MP:00053878.2PTGS2, IL36RN, IL22, IL8
6MP:00053768.1ALB, IL22, IL36RN, PTGS2

Publications for Acute Generalized Exanthematous Pustulosis

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Sources:
53PubMed
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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 256)
idTitleAuthorsYear
1
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
2
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
3
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
4
Acute generalized exanthematous pustulosis during antituberculosis therapy. (23698216)
2013
5
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
6
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
7
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
8
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
9
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
10
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
11
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
12
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
13
Acute generalized exanthematous pustulosis induced by docetaxel. (21595682)
2011
14
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
15
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
16
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
17
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
18
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
19
Acute generalized exanthematous pustulosis in a patient after stem cell transplantation. (20642988)
2010
20
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
21
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
22
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
23
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
24
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
25
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
26
A severe case of acute generalized exanthematous pustulosis (AGEP) in a child after the administration of amoxicillin-clavulanic acid: brief report. (19840330)
2009
27
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
28
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
29
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
30
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
31
Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. (19123438)
2008
32
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
33
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
34
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
35
Acute generalized exanthematous pustulosis from dalteparin. (17610994)
2007
36
Acute generalized exanthematous pustulosis (AGEP) after oral use of amphotericin B. (17637385)
2007
37
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
38
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
39
Acute generalized exanthematous pustulosis induced by topical lindane. (15459542)
2004
40
A case of recurrent acute generalized exanthematous pustulosis due to beta-lactam antibiotics: a case report. (12745858)
2003
41
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
42
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
43
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
44
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
45
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
46
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
47
Acute generalized exanthematous pustulosis due to teicoplanin. (11306839)
2001
48
Acute generalized exanthematous pustulosis induced by icodextrin. (11899129)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems
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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response MIF in innate immunity response61
9.4IL8, PTGS2
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.4PTGS2, IL8
39.4IL8, PTGS2
49.4IL8, PTGS2
5
Show member pathways
thioredoxin pathway39
9.3PTGS2, ALB
6
Show member pathways
9.1IL22, PTGS2
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.0IL8, IL36RN, PTGS2
8
Show member pathways
8.6IL8, IL22, PTGS2
9
Show member pathways
8.6PTGS2, IL22, IL8

Compounds for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources:
46Novoseek, 12DrugBank, 3BitterDB, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1nonoxynol-946 1210.9IL8, PTGS2
2triptolide469.8IL8, PTGS2
3parthenolide46 310.8PTGS2, IL8
4ciglitazone46 3010.8PTGS2, IL8
5sulfasalazine30 46 52 1212.8IL8, PTGS2
6ns 39846 6210.8IL8, PTGS2
7etanercept46 52 1211.8IL8, PTGS2
8fenoprofen30 46 1211.7ALB, PTGS2
9tolmetin46 1210.7ALB, PTGS2
10diflunisal46 1210.7ALB, PTGS2
11suprofen46 1210.7PTGS2, ALB
12phenylbutazone46 1210.7ALB, PTGS2
13piroxicam46 1210.7PTGS2, ALB
14etodolac46 1210.7PTGS2, ALB
15ketoprofen30 46 1211.7PTGS2, ALB
16naproxen46 25 1211.7PTGS2, ALB
1715-deoxy-delta-12,14-prostaglandin j2469.7PTGS2, IL8
18antipyrine46 1210.7ALB, PTGS2
19flurbiprofen46 30 52 1212.7ALB, PTGS2
20pdtc469.7IL8, PTGS2
21ag 1478469.7PTGS2, IL8
22sulindac46 1210.7ALB, PTGS2
23erlotinib46 52 1211.7PTGS2, ALB
24diclofenac46 30 52 1212.6ALB, PTGS2
25ibuprofen46 30 52 25 1213.6PTGS2, ALB
26salicylic acid46 3010.6ALB, PTGS2
27mifepristone46 30 62 1212.6IL8, PTGS2
28celecoxib46 62 30 52 25 1214.6ALB, PTGS2
29troglitazone46 30 62 1212.6IL8, PTGS2
30gefitinib46 52 1211.6ALB, PTGS2
31egcg469.5IL8, PTGS2
32irinotecan46 52 1211.5PTGS2, ALB
33herbimycin a46 6210.4IL8, PTGS2
34heme30 25 1211.3ALB, PTGS2
35hyaluronic acid46 2510.2ALB, IL8
36curcumin469.1IL8, PTGS2
37oxygen46 259.7PTGS2, IL22, IL8

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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17Gene Ontology
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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.3ALB, PTGS2
2extracellular spaceGO:0056157.8ALB, IL8, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:0015259.4IL8, PTGS2
2cellular component movementGO:0069289.1IL8, PTGS2
3response to glucocorticoidGO:0513849.0IL22, PTGS2
4inflammatory responseGO:0069548.6IL8, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.3ALB, PTGS2
2cytokine activityGO:0051258.9IL22, IL36RN

Products for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources for Acute Generalized Exanthematous Pustulosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet