AGEP
MCID: ACT167
MIFTS: 38

Acute Generalized Exanthematous Pustulosis (AGEP) malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 56 69
Agep 56 69
Pustular Drug Eruption 56
Toxic Pustuloderma 56

Characteristics:

Orphanet epidemiological data:

56
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA293173
UMLS via Orphanet 70 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and psoriasis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Saxagliptin and Eslicarbazepine acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells.

Wikipedia : 71 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

Related Diseases for Acute Generalized Exanthematous Pustulosis

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.2 CXCL8 IL17A PTGS2
2 psoriasis 10.5
3 pustular psoriasis 10.4
4 parkinson disease 11 10.2 CXCL8 IL17A
5 trichomalacia 10.2 CXCL8 IL17A
6 gastric dilatation 10.2 CXCL8 IL17A
7 diaphragmatic eventration 10.1 IL17A IL36RN
8 krukenberg carcinoma 10.1 IL17A IL36RN
9 burns 10.1 CXCL8 IL17A
10 balkan nephropathy 10.1 CXCL8 IL17A
11 nephronophthisis 1, juvenile 10.1 CXCL8 IL36RN
12 xanthogranulomatous cholecystitis 10.1 CXCL8 IL17A
13 paragonimiasis 10.1 CXCL8 IL17A
14 parasitic protozoa infectious disease 10.1 CXCL8 IL17A
15 phaeohyphomycosis 10.1 IL17A IL22
16 optic nerve hypoplasia 10.1 CXCL8 IL17A
17 chronic gonorrhea of cervix 10.1 IL17A IL17F
18 dermatitis 10.1
19 contact dermatitis 10.1
20 allergic contact dermatitis 10.1
21 pancreatitis 10.1
22 leukemia 10.1
23 pneumonia 10.1
24 ulcerative colitis 10.1
25 myeloid leukemia 10.1
26 colitis 10.1
27 spontaneous ocular nystagmus 10.0 CXCL8 IL17A
28 acute chest syndrome 10.0 CXCL8 IL17A
29 breast intracanalicular fibroadenoma 10.0 CXCL8 PTGS2
30 fungal gastritis 10.0 CXCL8 IL17F
31 hidradenitis 10.0 CXCL8 PTGS2
32 nasal cavity cancer 10.0 CXCL8 PTGS2
33 mandibular cancer 10.0 CXCL8 PTGS2
34 uterine ligament clear cell adenocarcinoma 10.0 CXCL8 IL17A
35 childhood central nervous system mixed germ cell tumor 10.0 CXCL8 PTGS2
36 childhood intracortical osteosarcoma 10.0 CXCL8 PTGS2
37 atrophic gastritis 10.0 CXCL8 IL17A IL36RN
38 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.0 CXCL8 PTGS2
39 conjunctival concretion 9.9 CXCL8 PTGS2
40 glycogen storage disease ix 9.9 CXCL8 IL17A IL22
41 neovascular glaucoma 9.9 CXCL8 PTGS2
42 vulvar nodular hidradenoma 9.9 IL17A IL17F IL22
43 lung cancer 9.9
44 cystic echinococcosis 9.9
45 leprosy 9.9
46 echinococcosis 9.9
47 cytomegalovirus infection 9.9
48 multiple myeloma 9.9
49 neuritis 9.9
50 drug rash with eosinophilia and systemic symptoms 9.9

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Saxagliptin Approved 361442-04-8 11243969
2
Eslicarbazepine acetate Approved 75970-99-9, 236395-14-5 123618
3
protease inhibitors
4 HIV Protease Inhibitors
5 Hormone Antagonists
6 Dipeptidyl-Peptidase IV Inhibitors
7 Hormones
8 Hormones, Hormone Substitutes, and Hormone Antagonists
9 Hypoglycemic Agents
10 Incretins
11 Sodium Channel Blockers
12 Diuretics, Potassium Sparing

Interventional clinical trials:


id Name Status NCT ID Phase
1 Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086319
2 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342
3 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
4 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
5 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

Anatomical Context for Acute Generalized Exanthematous Pustulosis

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

39
Testes, Skin, T Cells, Myeloid, Neutrophil, Liver, Lung

Publications for Acute Generalized Exanthematous Pustulosis

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 333)
id Title Authors Year
1
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013. ( 28084022 )
2017
2
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. ( 27023083 )
2016
3
DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case reporta8c. ( 27443659 )
2016
4
Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma. ( 27031538 )
2016
5
Koebnerization of Hailey-Hailey disease into a cutaneous drug eruption of acute generalized exanthematous pustulosis associated with systemic symptoms. ( 27433827 )
2016
6
Piperacillin/Tazobactam-Associated Hypersensitivity Syndrome with Overlapping Features of Acute Generalized Exanthematous Pustulosis and Drug-Related Rash with Eosinophilia and Systemic Symptoms Syndrome. ( 26848226 )
2016
7
Dermoscopy as an auxiliary tool in the early differential diagnosis of acute generalized exanthematous pustulosis (AGEP) and exanthematous (morbilliform) drug eruption. ( 26775791 )
2016
8
Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly. ( 27354743 )
2016
9
Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing. ( 26831480 )
2016
10
Acute generalized exanthematous pustulosis associated with spider bite. ( 27579754 )
2016
11
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. ( 27025295 )
2016
12
Lornoxicam-induced acute generalized exanthematous pustulosis. ( 26971725 )
2016
13
Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy. ( 27472323 )
2016
14
Acute Generalized Exanthematous Pustulosis Induced by Fexofenadine. ( 27057044 )
2016
15
Lincomycin-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Delayed Reading of Intradermal Testing. ( 27371545 )
2016
16
Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy. ( 27334410 )
2016
17
First case of acute generalized exanthematous pustulosis caused by pitavastatin: possible pathogenetic role of IL-36. ( 26679546 )
2016
18
Enzalutamide induced acute generalized exanthematous pustulosis. ( 27900064 )
2016
19
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. ( 27489427 )
2016
20
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis. ( 26931079 )
2016
21
Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy. ( 25997755 )
2015
22
Images in clinical medicine. Acute generalized exanthematous pustulosis. ( 25564899 )
2015
23
Acute Generalized Exanthematous Pustulosis Due to Insect Bites? ( 26288442 )
2015
24
Acute generalized exanthematous pustulosis possibly induced by isoniazid in a patient with psoriatic erythroderma. ( 25514351 )
2015
25
Acute Generalized Exanthematous Pustulosis: An Uncommon Cause of Fever and Rash. ( 26231526 )
2015
26
Acute generalized exanthematous pustulosis induced by Mycoplasma pneumoniae infection. ( 26427049 )
2015
27
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis: a coincidence? ( 25677856 )
2015
28
Acute generalized exanthematous pustulosis induced by mifepristone. ( 27051727 )
2015
29
First case report of acute generalized exanthematous pustulosis due to labetalol. ( 25997315 )
2015
30
Acute generalized exanthematous pustulosis secondary to azathioprine. ( 25657412 )
2015
31
Fluconazole-induced acute generalized exanthematous pustulosis. ( 25814733 )
2015
32
Acute Generalized Exanthematous Pustulosis Caused by Faropenem: A Possible Pathogenetic Role for Interleukin-23. ( 26302837 )
2015
33
Images in emergency medicine. Acute generalized exanthematous pustulosis. ( 25601249 )
2015
34
Ticagrelor-induced acute generalized exanthematous pustulosis. ( 25965589 )
2015
35
Acute generalized exanthematous pustulosis (AGEP): A review and update. ( 26354880 )
2015
36
Acute generalized exanthematous pustulosis x Von Zumbusch's pustular psoriasis: A diagnostic challenge in a psoriatic patient. ( 26375226 )
2015
37
Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. ( 26561525 )
2015
38
Acute generalized exanthematous pustulosis associated with ranolazine. ( 26682297 )
2015
39
Probable fenofibrate-induced acute generalized exanthematous pustulosis. ( 26581932 )
2015
40
An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis. ( 26688759 )
2015
41
Acute generalized exanthematous pustulosis by azithromycin. ( 25784092 )
2015
42
Acute generalized exanthematous pustulosis induced by celecoxib. ( 26488335 )
2015
43
Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis. ( 26783390 )
2015
44
Acute generalized exanthematous pustulosis due to meropenem: An unusual side effect of a commonly used drug. ( 26751943 )
2015
45
Generalized Pustulosis Diagnosed as Acute Generalized Exanthematous Pustulosis: Tzanck Smear and Pathological Evaluation of the Pustule Roof Can Provide Evidence for Early Diagnosis. ( 26512180 )
2015
46
Acute generalized exanthematous pustulosis in a child probably induced by terbinafine. ( 25566924 )
2015
47
A case of acute generalized exanthematous pustulosis associated with polyarteritis nodosa, responding to systemic steroids. ( 25846351 )
2015
48
Acute generalized exanthematous pustulosis following paracetamol ingestion in a child. ( 25845401 )
2015
49
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing. ( 26729969 )
2015
50
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review. ( 26273160 )
2015

Variations for Acute Generalized Exanthematous Pustulosis

Expression for Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for Acute Generalized Exanthematous Pustulosis

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CXCL8 IL17A IL17F IL22 PTGS2
2
Show member pathways
12.83 CXCL8 IL17A IL17F IL22 PTGS2
3
Show member pathways
12.47 CXCL8 IL17A IL22
4
Show member pathways
12.19 IL17A IL17F IL22
5 11.66 CXCL8 PTGS2
6
Show member pathways
11.59 CXCL8 IL17A IL17F PTGS2
7 11.55 CXCL8 PTGS2
8 11.52 CXCL8 IL17A
9 11.45 IL17A IL22
10
Show member pathways
11.44 IL17A IL17F IL22
11
Show member pathways
11.42 CXCL8 PTGS2
12
Show member pathways
11.32 CXCL8 PTGS2
13
Show member pathways
11.3 CXCL8 IL17A IL17F
14 11.22 CXCL8 PTGS2
15 11.18 CXCL8 PTGS2
16 10.98 CXCL8 IL17A IL17F PTGS2
17 10.96 IL17A IL22
18 10.81 CXCL8 IL17A IL22
19 10.65 CXCL8 PTGS2

GO Terms for Acute Generalized Exanthematous Pustulosis

Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL8 IL17A IL17F IL22 IL36RN
2 extracellular space GO:0005615 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.54 CXCL8 IL17A IL36RN
2 movement of cell or subcellular component GO:0006928 9.4 CXCL8 PTGS2
3 cellular response to interleukin-1 GO:0071347 9.32 CXCL8 IL17A
4 response to glucocorticoid GO:0051384 9.26 IL22 PTGS2
5 positive regulation of interleukin-6 secretion GO:2000778 9.16 IL17A IL17F
6 inflammatory response GO:0006954 9.1 CXCL8 IL17A IL17F IL22 IL36RN PTGS2
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.96 IL17A IL17F

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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