MCID: ACT167
MIFTS: 43

Acute Generalized Exanthematous Pustulosis malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

About this section
Sources:
51Orphanet, 65UMLS, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 51 65
Agep 51 65
 
Pustular Drug Eruption 51
Toxic Pustuloderma 51

Characteristics:

Orphanet epidemiological data:

51
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Orphanet51 293173
UMLS via Orphanet66 C0877055
UMLS65 C0877055, C0863129

Summaries for Acute Generalized Exanthematous Pustulosis

About this section
Wikipedia:68 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and psoriasis, and has symptoms including mucosal toxicity, application site pustules and pustular rash. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways are Rheumatoid arthritis and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include skin, testes and liver.

Related Diseases for Acute Generalized Exanthematous Pustulosis

About this section

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis29.1CXCL8, IL17A, PTGS2
2psoriasis10.6
3pustular psoriasis10.5
4neonatal infective mastitis10.4CXCL8, IL17A
5nasopharyngitis10.3CXCL8, IL17A
6bronchopulmonary dysplasia10.3CXCL8, IL17A
7kohler's disease10.3CXCL8, IL17A
8liver leiomyosarcoma10.3CXCL8, IL17A
9long bone adamantinoma10.3CXCL8, IL17A
10diffuse scleroderma10.3CXCL8, IL17A
11foveal hypoplasia 110.2CXCL8, IL17A
12eosinophilic gastritis10.2CXCL8, IL17F
13leukemia10.2
14ulcerative colitis10.2
15colitis10.2
16dermatitis10.2
17contact dermatitis10.2
18allergic contact dermatitis10.2
19pancreatitis10.2
20pneumonia10.2
21myeloid leukemia10.2
22eosinophilia10.2
23avoidant personality disorder10.1IL17A, IL17F
24meningeal melanomatosis10.1CXCL8, IL17A
25lung cancer10.0
26leprosy10.0
27multiple myeloma10.0
28pancreatic cancer10.0
29arthritis10.0
30glomerulonephritis10.0
31hemolytic anemia10.0
32erythema multiforme10.0
33myeloma10.0
34mumps10.0
35optic neuritis10.0
36cystic echinococcosis10.0
37echinococcosis10.0
38neuritis10.0
39melanoma10.0
40acute pancreatitis10.0
41lymphangitis10.0
42polyarteritis nodosa10.0
43hypoglycemia10.0
44cytomegalovirus infection10.0
45drug rash with eosinophilia and systemic symptoms10.0
46urea cycle disorder10.0CXCL8, IL17A
47immunodeficiency 27b, mycobacteriosis, ad10.0CXCL8, PTGS2
48spleen angiosarcoma10.0CXCL8, PTGS2
49eyelid neoplasm10.0CXCL8, PTGS2
50gonadal disease10.0CXCL8, PTGS2

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

About this section

UMLS symptoms related to Acute Generalized Exanthematous Pustulosis:


mucosal toxicity, application site pustules, pustular rash, skin manifestations, pruritus, exanthema

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

About this section

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Saxagliptinapproved120361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
BMS-477118
 
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
Saxagliptin Hydrochloride
2Incretins1326
3Protease Inhibitors4558
4Dipeptidyl-Peptidase IV Inhibitors779
5Hypoglycemic Agents4503
6Hormones, Hormone Substitutes, and Hormone Antagonists9988
7Hormone Antagonists10002
8HIV Protease Inhibitors4558
9Hormones11748
10Sodium Channel Blockers1180
11Diuretics, Potassium Sparing1445
12
Eslicarbazepine acetate6275970-99-9123618
Synonyms:
10-Acetoxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
236395-14-5
AC1L452K
AKOS005145781
B5435_SIGMA
BIA 2-093
BIA-2-093
CHEBI:239940
CHEMBL87992
CID179344
Erelib
 
Eslicarbazepine acetate
Exalief
MolPort-005-942-413
NCGC00165752-01
NCGC00165752-02
Pazzul
S-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
SEP-0002093
Stedesa
ZINC00007295
Zebinix
[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsCompletedNCT01086319
2Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275
3Severe Cutaneous Adverse Reactions in ThailandRecruitingNCT02574988
4An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine AcetateRecruitingNCT02520557

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

About this section

Anatomical Context for Acute Generalized Exanthematous Pustulosis

About this section

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

33
Skin, Testes, Liver, Endothelial, Neutrophil, Lung, Prostate

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

About this section

Publications for Acute Generalized Exanthematous Pustulosis

About this section

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. (27025295)
2016
2
Lornoxicam-induced acute generalized exanthematous pustulosis. (26971725)
2016
3
Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. (26561525)
2015
4
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
5
Probable fenofibrate-induced acute generalized exanthematous pustulosis. (26581932)
2015
6
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. (24888401)
2014
7
Pancreatitis-associated with riluzole; linezolid-induced hypoglycemia; sorafenib-induced acute generalized exanthematous pustulosis; creatine supplementation-induced thrombotic events; acute pancreatitis associated with quetiapine; hypomagnesemia and seizure associated with rabeprazole. (25673887)
2014
8
Acute generalized exanthematous pustulosis associated with tigecycline. (24882982)
2014
9
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
10
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
11
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
12
Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection. (24986490)
2014
13
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
14
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
15
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
16
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
17
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
18
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
19
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
20
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
21
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
22
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
23
Acute generalized exanthematous pustulosis induced by docetaxel. (21595682)
2011
24
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
25
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
26
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
27
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
28
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
29
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
30
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
31
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
32
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
33
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
34
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
35
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
36
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
37
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
38
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
39
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
40
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
41
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
42
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
43
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
44
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
45
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
46
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
47
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
48
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

About this section

Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

About this section
Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

About this section

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6CXCL8, IL17A
29.4IL17A, IL22
39.2CXCL8, PTGS2
49.2CXCL8, PTGS2
5
Show member pathways
9.2CXCL8, PTGS2
6
Show member pathways
9.1CXCL8, IL17A, IL17F
7
Show member pathways
8.9IL17A, IL17F, IL22
8
Show member pathways
8.9IL17A, IL17F, IL22
9
Show member pathways
8.7CXCL8, IL36RN, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

About this section

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 secretionGO:200077810.0IL17A, IL17F
2positive regulation of cytokine production involved in inflammatory responseGO:19000179.6IL17A, IL17F
3movement of cell or subcellular componentGO:00069289.2CXCL8, PTGS2
4response to glucocorticoidGO:00513848.9IL22, PTGS2

Sources for Acute Generalized Exanthematous Pustulosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet