MCID: ACT167
MIFTS: 42

Acute Generalized Exanthematous Pustulosis

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 55 69
Agep 55 69
Pustular Drug Eruption 55
Toxic Pustuloderma 55

Characteristics:

Orphanet epidemiological data:

55
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA293173
UMLS via Orphanet 70 C0877055 C0853331

Summaries for Acute Generalized Exanthematous Pustulosis

MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to allergic contact dermatitis and contact dermatitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Saxagliptin and Eslicarbazepine acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil.

Wikipedia : 72 Acute generalized exanthematous pustulosis (AGEP) (also known as \"pustular drug eruption\" and \"toxic... more...

Related Diseases for Acute Generalized Exanthematous Pustulosis

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 30.5 CXCL8 IL17A
2 contact dermatitis 30.4 CXCL8 IL17A
3 psoriasis 29.9 CXCL8 IL17A IL22 IL36RN
4 arthritis 29.4 CXCL8 IL17A PTGS2
5 rheumatoid arthritis 29.2 CXCL8 IL17A PTGS2
6 pustulosis of palm and sole 10.5
7 pustular psoriasis 10.5
8 allergic hypersensitivity disease 10.3
9 psoriasis 14, pustular 10.3
10 transverse myelitis 10.2 CXCL8 IL17A
11 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.2
12 severe cutaneous adverse reaction 10.2
13 common cold 10.2 CXCL8 IL17A
14 upper respiratory tract disease 10.2 CXCL8 IL17A
15 nasopharyngitis 10.2 IL17A IL17F
16 bronchiolitis obliterans 10.2 CXCL8 IL17A
17 nasopharyngeal disease 10.2 IL17A IL17F
18 mastitis 10.2 CXCL8 IL17A
19 bronchial disease 10.2 CXCL8 IL17A
20 leukemia 10.1
21 pancreatitis 10.1
22 ulcerative colitis 10.1
23 pneumonia 10.1
24 colitis 10.1
25 myeloid leukemia 10.1
26 leukemia, chronic myeloid 10.1
27 dermatitis 10.1
28 intestinal disease 10.1 CXCL8 IL17A
29 respiratory system disease 10.1 CXCL8 IL17A
30 autoimmune polyendocrine syndrome 10.1 IL17A IL22
31 periodontitis 10.1 CXCL8 IL17A
32 candidiasis 10.0 IL17A IL17F
33 alcoholic hepatitis 10.0 CXCL8 IL22
34 allergic asthma 10.0 CXCL8 IL17A
35 hemolytic anemia 10.0
36 acute pancreatitis 10.0
37 small cell cancer of the lung 10.0
38 hepatitis 10.0
39 lung cancer 10.0
40 leprosy 3 10.0
41 osteonecrosis 10.0
42 myeloma, multiple 10.0
43 pancreatic cancer 10.0
44 erythema multiforme 10.0
45 influenza 10.0
46 psoriasis 2 10.0
47 psoriasis 7 10.0
48 mumps 10.0
49 lymphangitis 10.0
50 optic neuritis 10.0

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Saxagliptin Approved 361442-04-8 11243969
2
Eslicarbazepine acetate Approved 236395-14-5, 75970-99-9 123618
3
Petrolatum Approved, Investigational 8009-03-8
4
protease inhibitors
5 HIV Protease Inhibitors
6 Hormone Antagonists
7 Hormones
8 Dipeptidyl-Peptidase IV Inhibitors
9 Hormones, Hormone Substitutes, and Hormone Antagonists
10 Hypoglycemic Agents
11 Incretins
12 Sodium Channel Blockers
13 Diuretics, Potassium Sparing

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086319
2 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342
3 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
4 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
5 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

Anatomical Context for Acute Generalized Exanthematous Pustulosis

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

38
Skin, Testes, Neutrophil, T Cells, Myeloid, Liver, Kidney

Publications for Acute Generalized Exanthematous Pustulosis

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 361)
# Title Authors Year
1
First case report of acute generalized exanthematous pustulosis (AGEP) caused by gadolinium confirmed by patch testing. ( 29341190 )
2018
2
Acute generalized exanthematous pustulosis simulating Stevens-Johnson syndrome/toxic epidermal necrolysis associated with the use of vismodegib. ( 29387760 )
2018
3
Varenicline-induced acute generalized exanthematous pustulosis confirmed by patch testing. ( 29265452 )
2018
4
Two cases of annular acute generalized exanthematous pustulosis induced by terbinafine. ( 29336314 )
2018
5
Acute generalized exanthematous pustulosis associated with Helicobacter pylori eradication therapy with elevated serum procalcitonin. ( 29400303 )
2018
6
Acute generalized exanthematous pustulosis with multisystem manifestations: Pinpoint pustules and purulent lakes. ( 29273137 )
2018
7
Acute Generalized Exanthematous Pustulosis Simulating Toxic Epidermal Necrolysis: Overlapping Processes. ( 29402393 )
2018
8
A Plethora of Pustules: Acute Generalized Exanthematous Pustulosis. ( 29425705 )
2018
9
A Case of Acute Generalized Exanthematous Pustulosis after Injection of an Erythropoiesis-Stimulating Agent. ( 29386844 )
2018
10
Acute generalized exanthematous pustulosis induced by a digestive enzyme drug, Festal<sup>Ar</sup>. ( 29341242 )
2018
11
Sorafenib-induced Acute Generalized Exanthematous Pustulosis: An Increasing Association? ( 28262110 )
2017
12
Bendamustine-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Patch Testing. ( 28617679 )
2017
13
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report. ( 28703347 )
2017
14
Clindamycin-associated acute generalized exanthematous pustulosis. ( 28417476 )
2017
15
Acute Generalized Exanthematous Pustulosis (AGEP) associated to Epstein-Barr Virus (EBV) infection reactivation. ( 28704988 )
2017
16
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation. ( 29186260 )
2017
17
Acute generalized exanthematous pustulosis (AGEP) induced by azithromycin. ( 28497632 )
2017
18
Oral lesions of acute generalized exanthematous pustulosis. ( 28952158 )
2017
19
Acute generalized exanthematous pustulosis caused by an iodinated contrast radiocontrast medium for computed tomography arthrography of the knee. ( 28497630 )
2017
20
Acute generalized exanthematous pustulosis secondary to levetiracetam and valproic acid use. ( 28189379 )
2017
21
Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis. ( 28559812 )
2017
22
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013. ( 28084022 )
2017
23
Life-Threatening Atypical Case of Acute Generalized Exanthematous Pustulosis. ( 29065395 )
2017
24
Acute generalized exanthematous pustulosis associated with ipilimumab and nivolumab. ( 28430376 )
2017
25
Severe drug-induced kidney injury in acute generalized exanthematous pustulosis. ( 29222845 )
2017
26
A Case of Amoxicillin-Induced Acute Generalized Exanthematous Pustulosis Presenting as Septic Shock. ( 28358593 )
2017
27
Acute Generalized Exanthematous Pustulosis. ( 28361791 )
2017
28
Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation. ( 28776328 )
2017
29
Is neutrophilic desquamative erythroderma a form of acute generalized exanthematous pustulosis? ( 29224230 )
2017
30
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. ( 27023083 )
2016
31
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. ( 27489427 )
2016
32
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. ( 27025295 )
2016
33
Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy. ( 27472323 )
2016
34
Piperacillin/Tazobactam-Associated Hypersensitivity Syndrome with Overlapping Features of Acute Generalized Exanthematous Pustulosis and Drug-Related Rash with Eosinophilia and Systemic Symptoms Syndrome. ( 26848226 )
2016
35
Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly. ( 27354743 )
2016
36
Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma. ( 27031538 )
2016
37
First case of acute generalized exanthematous pustulosis caused by pitavastatin: possible pathogenetic role of IL-36. ( 26679546 )
2016
38
Koebnerization of Hailey-Hailey disease into a cutaneous drug eruption of acute generalized exanthematous pustulosis associated with systemic symptoms. ( 27433827 )
2016
39
Enzalutamide induced acute generalized exanthematous pustulosis. ( 27900064 )
2016
40
Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing. ( 26831480 )
2016
41
Lornoxicam-induced acute generalized exanthematous pustulosis. ( 26971725 )
2016
42
Lincomycin-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Delayed Reading of Intradermal Testing. ( 27371545 )
2016
43
DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case reporta8c. ( 27443659 )
2016
44
Acute generalized exanthematous pustulosis associated with spider bite. ( 27579754 )
2016
45
Acute Generalized Exanthematous Pustulosis Induced by Fexofenadine. ( 27057044 )
2016
46
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis. ( 26931079 )
2016
47
Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy. ( 27334410 )
2016
48
Dermoscopy as an auxiliary tool in the early differential diagnosis of acute generalized exanthematous pustulosis (AGEP) and exanthematous (morbilliform) drug eruption. ( 26775791 )
2016
49
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing. ( 26729969 )
2015
50
An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis. ( 26688759 )
2015

Variations for Acute Generalized Exanthematous Pustulosis

Expression for Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for Acute Generalized Exanthematous Pustulosis

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CXCL8 IL17A IL17F IL22 PTGS2
2
Show member pathways
12.83 CXCL8 IL17A IL17F IL22 PTGS2
3
Show member pathways
12.47 CXCL8 IL17A IL22
4
Show member pathways
12.19 IL17A IL17F IL22
5 11.67 CXCL8 PTGS2
6
Show member pathways
11.59 CXCL8 IL17A IL17F PTGS2
7 11.56 CXCL8 PTGS2
8 11.52 CXCL8 IL17A
9 11.45 IL17A IL22
10
Show member pathways
11.42 CXCL8 PTGS2
11
Show member pathways
11.4 CXCL8 IL17A IL17F
12
Show member pathways
11.32 CXCL8 PTGS2
13
Show member pathways
11.29 IL17A IL17F IL22
14 11.22 CXCL8 PTGS2
15 11.18 CXCL8 PTGS2
16 10.98 CXCL8 IL17A IL17F PTGS2
17 10.96 IL17A IL22
18 10.77 CXCL8 IL17A IL22
19 10.68 CXCL8 PTGS2
20 10.66 CXCL8 IL17A IL22

GO Terms for Acute Generalized Exanthematous Pustulosis

Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL8 IL17A IL17F IL22 IL36RN
2 extracellular space GO:0005615 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 CXCL8 IL17A IL36RN
2 movement of cell or subcellular component GO:0006928 9.43 CXCL8 PTGS2
3 cellular response to interleukin-1 GO:0071347 9.4 CXCL8 IL17A
4 response to glucocorticoid GO:0051384 9.37 IL22 PTGS2
5 regulation of receptor activity GO:0010469 9.35 CXCL8 IL17A IL17F IL22 IL36RN
6 positive regulation of interleukin-6 secretion GO:2000778 9.32 IL17A IL17F
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.26 IL17A IL17F
8 cellular response to interleukin-17 GO:0097398 9.16 IL17A IL17F
9 inflammatory response GO:0006954 9.1 CXCL8 IL17A IL17F IL22 IL36RN PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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