MCID: ACT167
MIFTS: 40

Acute Generalized Exanthematous Pustulosis malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 54 68
Agep 54 68
 
Pustular Drug Eruption 54
Toxic Pustuloderma 54

Characteristics:

Orphanet epidemiological data:

54
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

Orphanet54 ORPHA293173
UMLS via Orphanet69 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:71 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to rheumatoid arthritis and psoriasis, and has symptoms including exanthema, pruritus and skin manifestations. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways are Rheumatoid arthritis and IL-17 Family Signaling Pathways. Affiliated tissues include skin, testes and neutrophil.

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.7CXCL8, IL17A, PTGS2
2psoriasis10.5
3pustular psoriasis10.4
4biliary tract disease10.3CXCL8, IL17A
5burn scar10.3CXCL8, IL17A
6chronic endophthalmitis10.3CXCL8, IL17A
7blind hypotensive eye10.3CXCL8, IL17A
8pyruvate kinase deficiency, liver type10.3IL17A, IL36RN
9lung sarcoma10.2CXCL8, IL17A
10rectum leiomyosarcoma10.2CXCL8, IL17A
11benign renovascular hypertension10.2CXCL8, IL17A
12uterine corpus endometrial stromal sarcoma10.2CXCL8, IL36RN
13laryngeal tuberculosis10.2CXCL8, IL17A
14foveal hypoplasia 110.2CXCL8, IL17A
15eosinophilic gastroenteritis10.2CXCL8, IL17F
16palmoplantar keratosis10.1CXCL8, IL17A
17personality disorder10.1IL17A, IL17F
18gingivitis10.1CXCL8, IL17A
19basaloid squamous cell carcinoma10.1CXCL8, IL17A
20leukemia10.1
21ulcerative colitis10.1
22colitis10.1
23dermatitis10.1
24contact dermatitis10.1
25allergic contact dermatitis10.1
26pancreatitis10.1
27pneumonia10.1
28myeloid leukemia10.1
29eosinophilia10.1
30microscopic colitis10.0CXCL8, IL17A
31benign fibrous mesothelioma9.9CXCL8, PTGS2
32tibialis tendinitis9.9CXCL8, PTGS2
33intracortical osteogenic sarcoma9.9CXCL8, PTGS2
34pediatric supratentorial ependymoma9.9CXCL8, PTGS2
35synostosis9.9CXCL8, PTGS2
36lung cancer9.9
37leprosy9.9
38multiple myeloma9.9
39pancreatic cancer9.9
40hailey-hailey disease9.9
41arthritis9.9
42glomerulonephritis9.9
43hemolytic anemia9.9
44hepatitis9.9
45osteonecrosis9.9
46erythema multiforme9.9
47mumps9.9
48optic neuritis9.9
49cystic echinococcosis9.9
50echinococcosis9.9

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

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UMLS symptoms related to Acute Generalized Exanthematous Pustulosis:


exanthema, pruritus, skin manifestations, pustular rash, application site pustules, mucosal toxicity

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Saxagliptinapproved126361442-04-811243969
Synonyms:
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile
(1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- (9CI)
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
361442-04-8
AC-6008
BMS 477118
BMS 477118-11
 
BMS-477118
BMS-477118-11
CHEBI:460723
CHEMBL385517
CID11243969
DB06335
OPC-262
Onglyza
S1540_Selleck
Saxagliptin
2
Eslicarbazepine acetateapproved6375970-99-9, 236395-14-5123618
Synonyms:
(10S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
(10S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate
10-Acetoxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
236395-14-5
AC1L452K
AKOS005145781
B5435_SIGMA
BIA 2-093
BIA-2-093
CHEBI:239940
CHEMBL87992
CID179344
 
ESL
Erelib
Eslicarbazepine acetate
Exalief
MolPort-005-942-413
NCGC00165752-01
NCGC00165752-02
Pazzul
S-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
SEP-0002093
Stedesa
ZINC00007295
Zebinix
[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate
3Incretins1537
4Dipeptidyl-Peptidase IV Inhibitors846
5
protease inhibitors5320
Synonyms:
 
protease inhibitors
6Hypoglycemic Agents5733
7HIV Protease Inhibitors5319
8Hormones, Hormone Substitutes, and Hormone Antagonists12767
9Hormone Antagonists12778
10Hormones13979
11Sodium Channel Blockers1515
12Diuretics, Potassium Sparing1827

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsCompletedNCT01086319
2Severe Cutaneous Adverse Reactions in ThailandRecruitingNCT02574988
3An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine AcetateRecruitingNCT02520557
4Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

36
Skin, Testes, Neutrophil, T cells, Myeloid, Liver, Lung

Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013. (28084022)
2017
2
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. (27025295)
2016
3
Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy. (27334410)
2016
4
Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly. (27354743)
2016
5
Koebnerization of Hailey-Hailey disease into a cutaneous drug eruption of acute generalized exanthematous pustulosis associated with systemic symptoms. (27433827)
2016
6
Dermoscopy as an auxiliary tool in the early differential diagnosis of acute generalized exanthematous pustulosis (AGEP) and exanthematous (morbilliform) drug eruption. (26775791)
2016
7
Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy. (27472323)
2016
8
Lincomycin-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Delayed Reading of Intradermal Testing. (27371545)
2016
9
Acute generalized exanthematous pustulosis associated with spider bite. (27579754)
2016
10
Piperacillin/Tazobactam-Associated Hypersensitivity Syndrome with Overlapping Features of Acute Generalized Exanthematous Pustulosis and Drug-Related Rash with Eosinophilia and Systemic Symptoms Syndrome. (26848226)
2016
11
Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma. (27031538)
2016
12
Lornoxicam-induced acute generalized exanthematous pustulosis. (26971725)
2016
13
Acute Generalized Exanthematous Pustulosis Induced by Fexofenadine. (27057044)
2016
14
DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case reporta8c. (27443659)
2016
15
Enzalutamide induced acute generalized exanthematous pustulosis. (27900064)
2016
16
Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing. (26831480)
2016
17
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. (27023083)
2016
18
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. (27489427)
2016
19
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis. (26931079)
2016
20
First case of acute generalized exanthematous pustulosis caused by pitavastatin: possible pathogenetic role of IL-36. (26679546)
2016
21
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
22
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis: a coincidence? (25677856)
2015
23
Acute Generalized Exanthematous Pustulosis Caused by Faropenem: A Possible Pathogenetic Role for Interleukin-23. (26302837)
2015
24
Acute generalized exanthematous pustulosis induced by celecoxib. (26488335)
2015
25
Acute generalized exanthematous pustulosis following paracetamol ingestion in a child. (25845401)
2015
26
Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy. (25997755)
2015
27
Acute generalized exanthematous pustulosis x Von Zumbusch's pustular psoriasis: A diagnostic challenge in a psoriatic patient. (26375226)
2015
28
Acute generalized exanthematous pustulosis in a child probably induced by terbinafine. (25566924)
2015
29
Images in emergency medicine. Acute generalized exanthematous pustulosis. (25601249)
2015
30
An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis. (26688759)
2015
31
Acute generalized exanthematous pustulosis secondary to azathioprine. (25657412)
2015
32
Acute generalized exanthematous pustulosis induced by mifepristone. (27051727)
2015
33
Acute generalized exanthematous pustulosis (AGEP): A review and update. (26354880)
2015
34
Acute generalized exanthematous pustulosis due to meropenem: An unusual side effect of a commonly used drug. (26751943)
2015
35
Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. (26561525)
2015
36
Probable fenofibrate-induced acute generalized exanthematous pustulosis. (26581932)
2015
37
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review. (26273160)
2015
38
Images in clinical medicine. Acute generalized exanthematous pustulosis. (25564899)
2015
39
Generalized Pustulosis Diagnosed as Acute Generalized Exanthematous Pustulosis: Tzanck Smear and Pathological Evaluation of the Pustule Roof Can Provide Evidence for Early Diagnosis. (26512180)
2015
40
Acute generalized exanthematous pustulosis possibly induced by isoniazid in a patient with psoriatic erythroderma. (25514351)
2015
41
A case of acute generalized exanthematous pustulosis associated with polyarteritis nodosa, responding to systemic steroids. (25846351)
2015
42
Acute Generalized Exanthematous Pustulosis: An Uncommon Cause of Fever and Rash. (26231526)
2015
43
Acute generalized exanthematous pustulosis by azithromycin. (25784092)
2015
44
Ticagrelor-induced acute generalized exanthematous pustulosis. (25965589)
2015
45
Acute generalized exanthematous pustulosis associated with ranolazine. (26682297)
2015
46
First case report of acute generalized exanthematous pustulosis due to labetalol. (25997315)
2015
47
Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis. (26783390)
2015
48
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing. (26729969)
2015
49
Acute generalized exanthematous pustulosis induced by Mycoplasma pneumoniae infection. (26427049)
2015
50
Acute Generalized Exanthematous Pustulosis Due to Insect Bites? (26288442)
2015

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.6CXCL8, IL17A
2
Show member pathways
9.5IL17A, IL17F
39.4IL17A, IL22
49.2CXCL8, PTGS2
5
Show member pathways
9.2CXCL8, PTGS2
69.2CXCL8, PTGS2
7
Show member pathways
9.0CXCL8, IL17A, IL22
89.0CXCL8, IL17A, IL22
9
Show member pathways
8.9IL17A, IL17F, IL22
10
Show member pathways
8.9IL17A, IL17F, IL22
11
Show member pathways
8.7CXCL8, IL36RN, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.2CXCL8, IL17A, IL17F, IL22
2extracellular spaceGO:00056157.9CXCL8, IL17A, IL17F, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:007134710.3CXCL8, IL17A
2positive regulation of cytokine production involved in inflammatory responseGO:190001710.1IL17A, IL17F
3positive regulation of interleukin-6 secretionGO:200077810.0IL17A, IL17F
4movement of cell or subcellular componentGO:00069289.7CXCL8, PTGS2
5immune responseGO:00069559.7CXCL8, IL17A, IL22
6response to glucocorticoidGO:00513849.0IL22, PTGS2
7inflammatory responseGO:00069548.2CXCL8, IL17A, IL17F, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:00051269.5IL17A, IL17F
2cytokine activityGO:00051258.8IL17A, IL17F, IL22, IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet