AGEP
MCID: ACT167
MIFTS: 46

Acute Generalized Exanthematous Pustulosis (AGEP) malady

Skin diseases, Rare diseases categories
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Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:65 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as AGEP, is related to ulcerative colitis and colitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (interleukin 36 receptor antagonist), and among its related pathways are Toll Comparative Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The compounds nonoxynol-9 and triptolide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
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Acute Generalized Exanthematous Pustulosis, Aliases & Descriptions:

Name: Acute Generalized Exanthematous Pustulosis 48 62
Agep 48 62
 
Pustular Drug Eruption 48
Toxic Pustuloderma 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 48 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

48
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Variable; Age of death: Normal


External Ids:

UMLS via Orphanet63 C0877055

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.6IL8, IL22
2colitis30.5IL8, IL22, PTGS2
3sepsis30.5ALB, IL8
4pneumonia30.4IL8, IL22
5arthritis30.4PTGS2, IL8, ALB
6lung cancer30.3ALB, PTGS2
7rheumatoid arthritis30.2PTGS2, IL22, IL8
8toxic epidermal necrolysis11.0
9psoriasis10.9
10generalized pustular psoriasis10.6
11chronic myeloid leukemia10.5
12leukemia10.5
13stevens-johnson syndrome10.5
14allergic contact dermatitis10.5
15contact dermatitis10.5
16dermatitis10.5
17myeloid leukemia10.5
18common cold10.4IL8
19glomerulonephritis10.4
20hemolytic anemia10.4
21multiple myeloma10.4
22pancreatic cancer10.4
23cystic echinococcosis10.4
24lymphangitis10.4
25mumps10.4
26erythema multiforme10.4
27echinococcosis10.4
28eosinophilia10.4
29leprosy10.4
30myeloma10.4
31neuritis10.4
32optic neuritis10.4
33pancreatitis10.4
34cytomegalovirus infection10.4
35drug rash with eosinophilia and systemic symptoms10.4
36bronchiolitis10.4IL8
37vascular disease10.2PTGS2, IL8
38peptic ulcer disease10.2PTGS2, IL8
39alcoholic hepatitis10.1IL8, ALB
40mastitis10.1ALB, IL8
41gastritis10.1IL8, PTGS2
42alcoholic liver cirrhosis10.1ALB, IL8
43rhinitis10.1ALB, IL8
44endometriosis10.1IL8, PTGS2
45meningitis10.1IL8, ALB
46cork-handlers' disease10.1ALB, IL8
47squamous cell carcinoma of the head and neck10.1PTGS2, IL8
48vasculitis10.0
49skin disease9.9IL8, IL22
50atherosclerosis9.8ALB, IL8, PTGS2

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drug clinical trials:

Search ClinicalTrials for Acute Generalized Exanthematous Pustulosis

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

32
Testes, Skin, T cells, Myeloid, Liver, Lung, Neutrophil

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, IL22, PTGS2
2MP:00053708.4ALB, IL22, PTGS2
3MP:00053978.3IL8, IL22, IL36RN, PTGS2
4MP:00053818.2PTGS2, IL22, ALB
5MP:00053878.2PTGS2, IL36RN, IL22, IL8
6MP:00053768.1ALB, IL22, IL36RN, PTGS2

Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. (24888401)
2014
2
Acute generalized exanthematous pustulosis associated with tigecycline. (24882982)
2014
3
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
4
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
5
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
6
Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection. (24986490)
2014
7
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
8
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
9
Acute generalized exanthematous pustulosis during antituberculosis therapy. (23698216)
2013
10
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
11
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
12
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
13
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
14
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
15
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
16
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
17
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
18
Acute generalized exanthematous pustulosis induced by docetaxel. (21595682)
2011
19
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
20
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
21
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
22
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
23
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
24
Acute generalized exanthematous pustulosis in a patient after stem cell transplantation. (20642988)
2010
25
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
26
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
27
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
28
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
29
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
30
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
31
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
32
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
33
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
34
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
35
Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. (19123438)
2008
36
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
37
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
38
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
39
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
40
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
41
A case of recurrent acute generalized exanthematous pustulosis due to beta-lactam antibiotics: a case report. (12745858)
2003
42
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
43
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
44
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
45
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
46
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
47
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
48
Acute generalized exanthematous pustulosis due to teicoplanin. (11306839)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Expression patterns in normal tissues for genes affiliated with Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response MIF in innate immunity response60
9.4IL8, PTGS2
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4PTGS2, IL8
39.4IL8, PTGS2
49.4IL8, PTGS2
5
Show member pathways
thioredoxin pathway37
9.3PTGS2, ALB
6
Show member pathways
9.1IL22, PTGS2
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0IL8, IL36RN, PTGS2
8
Show member pathways
8.6IL8, IL22, PTGS2
9
Show member pathways
8.6PTGS2, IL22, IL8

Compounds for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Compounds related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1nonoxynol-944 1110.9IL8, PTGS2
2triptolide449.8IL8, PTGS2
3parthenolide44 210.8PTGS2, IL8
4ciglitazone44 2810.8PTGS2, IL8
5sulfasalazine28 44 50 1112.8IL8, PTGS2
6ns 39844 6110.8IL8, PTGS2
7etanercept44 50 1111.8IL8, PTGS2
8fenoprofen28 44 1111.7ALB, PTGS2
9tolmetin44 1110.7ALB, PTGS2
10diflunisal44 1110.7ALB, PTGS2
11suprofen44 1110.7PTGS2, ALB
12phenylbutazone44 1110.7ALB, PTGS2
13piroxicam44 1110.7PTGS2, ALB
14etodolac44 1110.7PTGS2, ALB
15ketoprofen28 44 1111.7PTGS2, ALB
16naproxen44 24 1111.7PTGS2, ALB
1715-deoxy-delta-12,14-prostaglandin j2449.7PTGS2, IL8
18antipyrine44 1110.7ALB, PTGS2
19flurbiprofen44 28 50 1112.7ALB, PTGS2
20pdtc449.7IL8, PTGS2
21ag 1478449.7PTGS2, IL8
22sulindac44 1110.7ALB, PTGS2
23erlotinib44 50 1111.7PTGS2, ALB
24diclofenac44 28 50 1112.6ALB, PTGS2
25ibuprofen44 28 50 24 1113.6PTGS2, ALB
26salicylic acid44 2810.6ALB, PTGS2
27mifepristone44 28 61 1112.6IL8, PTGS2
28celecoxib44 61 28 50 24 1114.6ALB, PTGS2
29troglitazone44 28 61 1112.6IL8, PTGS2
30gefitinib44 50 1111.6ALB, PTGS2
31egcg449.5IL8, PTGS2
32irinotecan44 50 1111.5PTGS2, ALB
33herbimycin a44 6110.4IL8, PTGS2
34heme28 24 1111.3ALB, PTGS2
35hyaluronic acid44 2410.2ALB, IL8
36curcumin449.1IL8, PTGS2
37oxygen44 249.7PTGS2, IL22, IL8

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.3ALB, PTGS2
2extracellular spaceGO:0056157.8ALB, IL8, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:0015259.4IL8, PTGS2
2cellular component movementGO:0069289.1IL8, PTGS2
3response to glucocorticoidGO:0513849.0IL22, PTGS2
4inflammatory responseGO:0069548.6IL8, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.3ALB, PTGS2
2cytokine activityGO:0051258.9IL22, IL36RN

Products for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources for Acute Generalized Exanthematous Pustulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet