AGEP
MCID: ACT167
MIFTS: 25

Acute Generalized Exanthematous Pustulosis (AGEP) malady

Skin diseases category

Summaries for Acute Generalized Exanthematous Pustulosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards: Acute Generalized Exanthematous Pustulosis, also known as AGEP, is related to rheumatoid arthritis and arthritis. An important gene associated with Acute Generalized Exanthematous Pustulosis is PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways is Selenium Pathway. The compounds Magnesium salicylate and fenoprofen have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype normal.

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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48Orphanet, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

acute generalized exanthematous pustulosis 48 60
agep 48 60
pustular drug eruption 48
toxic pustuloderma 48


Related Diseases for Acute Generalized Exanthematous Pustulosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Clinical Features for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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32MalaCards
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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

32
Skin

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5ALB, PTGS2, IL36RN

Publications for Acute Generalized Exanthematous Pustulosis

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Genetic Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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37NCBI BioSystems Database
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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ALB, PTGS2

Compounds for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources:
11DrugBank, 28IUPHAR, 44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1Magnesium salicylate119.4ALB, PTGS2
2fenoprofen28 44 1111.4ALB, PTGS2
3tolmetin44 1110.4ALB, PTGS2
4Acetylsalicylic acid119.4PTGS2, ALB
5diflunisal44 1110.4PTGS2, ALB
6suprofen44 1110.4ALB, PTGS2
7Salicyclic acid119.4PTGS2, ALB
8phenylbutazone44 1110.3PTGS2, ALB
9etodolac44 1110.3PTGS2, ALB
10piroxicam44 1110.3PTGS2, ALB
11ketoprofen44 28 1111.3PTGS2, ALB
12naproxen44 11 2411.3ALB, PTGS2
13antipyrine44 1110.3PTGS2, ALB
14flurbiprofen44 28 49 1112.3ALB, PTGS2
15sulindac44 1110.3ALB, PTGS2
16erlotinib44 49 1111.2PTGS2, ALB
17diclofenac44 28 49 1112.2ALB, PTGS2
18ibuprofen44 28 49 11 2413.2ALB, PTGS2
19salicylic acid44 2810.1PTGS2, ALB
20celecoxib44 59 28 49 11 2414.1ALB, PTGS2
21irinotecan44 49 1111.0ALB, PTGS2
22indomethacin44 59 28 1112.0ALB, PTGS2
23gefitinib44 49 1110.9PTGS2, ALB
24heme28 11 2410.7ALB, PTGS2

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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16Gene Ontology
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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0ALB, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.0ALB, PTGS2

Products for genes affiliated with Acute Generalized Exanthematous Pustulosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Generalized Exanthematous Pustulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet