MCID: ACT167
MIFTS: 40

Acute Generalized Exanthematous Pustulosis malady

Skin diseases, Rare diseases categories

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Acute Generalized Exanthematous Pustulosis, Aliases & Descriptions:

Name: Acute Generalized Exanthematous Pustulosis 47 60
Agep 47 60
 
Pustular Drug Eruption 47
Toxic Pustuloderma 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 47 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

47
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet47 293173
UMLS via Orphanet61 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:63 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to ulcerative colitis and colitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (interleukin 36 receptor antagonist), and among its related pathways are Toll Comparative Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The compounds nonoxynol-9 and triptolide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drug clinical trials:

Search ClinicalTrials for Acute Generalized Exanthematous Pustulosis

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

31
Testes, Skin, T cells, Myeloid, Liver, Lung, Neutrophil

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, IL22, PTGS2
2MP:00053708.4ALB, IL22, PTGS2
3MP:00053978.3IL8, IL22, IL36RN, PTGS2
4MP:00053818.2PTGS2, IL22, ALB
5MP:00053878.2PTGS2, IL36RN, IL22, IL8
6MP:00053768.1ALB, IL22, IL36RN, PTGS2

Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 290)
idTitleAuthorsYear
1
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
2
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. (24888401)
2014
3
Pancreatitis-associated with riluzole; linezolid-induced hypoglycemia; sorafenib-induced acute generalized exanthematous pustulosis; creatine supplementation-induced thrombotic events; acute pancreatitis associated with quetiapine; hypomagnesemia and seizure associated with rabeprazole. (25673887)
2014
4
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
5
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
6
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
7
Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection. (24986490)
2014
8
Midodrine-induced acute generalized exanthematous pustulosis. (24897147)
2014
9
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
10
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
11
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
12
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
13
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
14
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
15
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
16
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
17
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
18
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
19
Acute generalized exanthematous pustulosis induced by docetaxel. (21595682)
2011
20
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
21
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
22
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
23
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
24
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
25
Acute generalized exanthematous pustulosis in a patient after stem cell transplantation. (20642988)
2010
26
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
27
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
28
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
29
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
30
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
31
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
32
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
33
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
34
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
35
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
36
Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. (19123438)
2008
37
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
38
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
39
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
40
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
41
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
42
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
43
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
44
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
45
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
46
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
47
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
48
Acute generalized exanthematous pustulosis due to teicoplanin. (11306839)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response MIF in innate immunity response58
9.4IL8, PTGS2
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4PTGS2, IL8
39.4IL8, PTGS2
49.4IL8, PTGS2
5
Show member pathways
thioredoxin pathway36
9.3PTGS2, ALB
6
Show member pathways
9.1IL22, PTGS2
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0IL8, IL36RN, PTGS2
8
Show member pathways
8.6IL8, IL22, PTGS2
9
Show member pathways
8.6PTGS2, IL22, IL8

Compounds for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Compounds related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1nonoxynol-943 1210.9IL8, PTGS2
2triptolide439.8IL8, PTGS2
3parthenolide43 210.8PTGS2, IL8
4ciglitazone43 2810.8PTGS2, IL8
5sulfasalazine28 43 49 1212.8IL8, PTGS2
6ns 39843 5910.8IL8, PTGS2
7etanercept43 49 1211.8IL8, PTGS2
8fenoprofen28 43 1211.7ALB, PTGS2
9tolmetin43 1210.7ALB, PTGS2
10diflunisal43 1210.7ALB, PTGS2
11suprofen43 1210.7PTGS2, ALB
12phenylbutazone43 1210.7ALB, PTGS2
13piroxicam43 1210.7PTGS2, ALB
14etodolac43 1210.7PTGS2, ALB
15ketoprofen28 43 1211.7PTGS2, ALB
16naproxen43 24 1211.7PTGS2, ALB
1715-deoxy-delta-12,14-prostaglandin j2439.7PTGS2, IL8
18antipyrine43 1210.7ALB, PTGS2
19flurbiprofen43 28 49 1212.7ALB, PTGS2
20pdtc439.7IL8, PTGS2
21ag 1478439.7PTGS2, IL8
22sulindac43 1210.7ALB, PTGS2
23erlotinib43 49 1211.7PTGS2, ALB
24diclofenac43 28 49 1212.6ALB, PTGS2
25ibuprofen43 28 49 24 1213.6PTGS2, ALB
26salicylic acid43 2810.6ALB, PTGS2
27mifepristone43 28 59 1212.6IL8, PTGS2
28celecoxib43 59 28 49 24 1214.6ALB, PTGS2
29troglitazone43 28 59 1212.6IL8, PTGS2
30gefitinib43 49 1211.6ALB, PTGS2
31egcg439.5IL8, PTGS2
32irinotecan43 49 1211.5PTGS2, ALB
33herbimycin a43 5910.4IL8, PTGS2
34heme28 24 1211.3ALB, PTGS2
35hyaluronic acid43 2410.2ALB, IL8
36curcumin439.1IL8, PTGS2
37oxygen43 249.7PTGS2, IL22, IL8

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.3ALB, PTGS2
2extracellular spaceGO:00056157.8ALB, IL8, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:00015259.4IL8, PTGS2
2cellular component movementGO:00069289.1IL8, PTGS2
3response to glucocorticoidGO:00513849.0IL22, PTGS2
4inflammatory responseGO:00069548.6IL8, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.3ALB, PTGS2
2cytokine activityGO:00051258.9IL22, IL36RN

Products for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources for Acute Generalized Exanthematous Pustulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet