MCID: ACT167
MIFTS: 38

Acute Generalized Exanthematous Pustulosis

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 56 69
Agep 56 69
Pustular Drug Eruption 56
Toxic Pustuloderma 56

Characteristics:

Orphanet epidemiological data:

56
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA293173
UMLS via Orphanet 70 C0877055 C0853331

Summaries for Acute Generalized Exanthematous Pustulosis

MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to acute pancreatitis and rheumatoid arthritis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Saxagliptin and Eslicarbazepine acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil.

Wikipedia : 72 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

Related Diseases for Acute Generalized Exanthematous Pustulosis

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Related Disease Score Top Affiliating Genes
1 acute pancreatitis 29.2 CXCL8 PTGS2
2 rheumatoid arthritis 28.9 CXCL8 IL17A PTGS2
3 psoriasis 10.5
4 pustular psoriasis 10.4
5 tricho onychic dysplasia 10.4 CXCL8 IL17A
6 myofascial pain syndrome 10.4 CXCL8 IL17A
7 pelvic varices 10.3 CXCL8 IL17A
8 burn scar 10.3 CXCL8 IL17A
9 patellar tendinitis 10.3 IL17A IL36RN
10 neonatal candidiasis 10.3 IL17A IL36RN
11 chronic endophthalmitis 10.3 CXCL8 IL17A
12 churg-strauss syndrome 10.3 CXCL8 IL17A
13 spontaneous ocular nystagmus 10.3 CXCL8 IL17A
14 cerebellar disease 10.3 CXCL8 IL17A
15 endometrial clear cell adenocarcinoma 10.2 CXCL8 IL17A
16 phaeohyphomycosis 10.2 IL17A IL22
17 acute chest syndrome 10.2 CXCL8 IL17A
18 optic nerve hypoplasia 10.2 CXCL8 IL17A
19 vulva fibroepithelial polyp 10.1 CXCL8 IL17A
20 chronic gonorrhea of cervix 10.1 IL17A IL17F
21 alopecia 10.1 CXCL8 IL22
22 leukemia 10.1
23 ulcerative colitis 10.1
24 colitis 10.1
25 dermatitis 10.1
26 contact dermatitis 10.1
27 allergic contact dermatitis 10.1
28 pancreatitis 10.1
29 pneumonia 10.1
30 myeloid leukemia 10.1
31 intracranial hypertension 10.0 CXCL8 IL17A
32 hidradenitis 10.0 CXCL8 PTGS2
33 tibialis tendinitis 9.9 CXCL8 PTGS2
34 fibrosarcomatous osteosarcoma 9.9 CXCL8 PTGS2
35 mandibular cancer 9.9 CXCL8 PTGS2
36 extrahepatic bile duct papillary adenoma 9.9 CXCL8 PTGS2
37 lung cancer 9.9
38 hailey-hailey disease 9.9
39 leprosy 9.9
40 multiple myeloma 9.9
41 pancreatic cancer 9.9
42 arthritis 9.9
43 glomerulonephritis 9.9
44 hemolytic anemia 9.9
45 hepatitis 9.9
46 osteonecrosis 9.9
47 erythema multiforme 9.9
48 mumps 9.9
49 optic neuritis 9.9
50 cystic echinococcosis 9.9

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Saxagliptin Approved 361442-04-8 11243969
2
Eslicarbazepine acetate Approved 75970-99-9, 236395-14-5 123618
3
Petrolatum Approved 8009-03-8
4
protease inhibitors
5 HIV Protease Inhibitors
6 Hormone Antagonists
7 Hormones
8 Dipeptidyl-Peptidase IV Inhibitors
9 Hormones, Hormone Substitutes, and Hormone Antagonists
10 Hypoglycemic Agents
11 Incretins
12 Sodium Channel Blockers
13 Diuretics, Potassium Sparing

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086319
2 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342
3 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
4 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
5 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

Anatomical Context for Acute Generalized Exanthematous Pustulosis

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

39
Skin, Testes, Neutrophil, T Cells, Myeloid, Liver, Lung

Publications for Acute Generalized Exanthematous Pustulosis

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 346)
id Title Authors Year
1
Bendamustine-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Patch Testing. ( 28617679 )
2017
2
Sorafenib-induced Acute Generalized Exanthematous Pustulosis: An Increasing Association? ( 28262110 )
2017
3
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report. ( 28703347 )
2017
4
Clindamycin-associated acute generalized exanthematous pustulosis. ( 28417476 )
2017
5
Oral lesions of acute generalized exanthematous pustulosis. ( 28952158 )
2017
6
Acute generalized exanthematous pustulosis associated with ipilimumab and nivolumab. ( 28430376 )
2017
7
Acute Generalized Exanthematous Pustulosis. ( 28361791 )
2017
8
Acute generalized exanthematous pustulosis caused by an iodinated contrast radiocontrast medium for computed tomography arthrography of the knee. ( 28497630 )
2017
9
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013. ( 28084022 )
2017
10
Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis. ( 28559812 )
2017
11
Acute generalized exanthematous pustulosis secondary to levetiracetam and valproic acid use. ( 28189379 )
2017
12
A Case of Amoxicillin-Induced Acute Generalized Exanthematous Pustulosis Presenting as Septic Shock. ( 28358593 )
2017
13
Acute generalized exanthematous pustulosis (AGEP) induced by azithromycin. ( 28497632 )
2017
14
Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation. ( 28776328 )
2017
15
Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma. ( 27031538 )
2016
16
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. ( 27023083 )
2016
17
Dermoscopy as an auxiliary tool in the early differential diagnosis of acute generalized exanthematous pustulosis (AGEP) and exanthematous (morbilliform) drug eruption. ( 26775791 )
2016
18
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. ( 27489427 )
2016
19
First case of acute generalized exanthematous pustulosis caused by pitavastatin: possible pathogenetic role of IL-36. ( 26679546 )
2016
20
Koebnerization of Hailey-Hailey disease into a cutaneous drug eruption of acute generalized exanthematous pustulosis associated with systemic symptoms. ( 27433827 )
2016
21
Enzalutamide induced acute generalized exanthematous pustulosis. ( 27900064 )
2016
22
Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing. ( 26831480 )
2016
23
Piperacillin/Tazobactam-Associated Hypersensitivity Syndrome with Overlapping Features of Acute Generalized Exanthematous Pustulosis and Drug-Related Rash with Eosinophilia and Systemic Symptoms Syndrome. ( 26848226 )
2016
24
Lincomycin-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Delayed Reading of Intradermal Testing. ( 27371545 )
2016
25
Lornoxicam-induced acute generalized exanthematous pustulosis. ( 26971725 )
2016
26
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis in patients with psoriasis. ( 26931079 )
2016
27
Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy. ( 27334410 )
2016
28
Acute generalized exanthematous pustulosis associated with spider bite. ( 27579754 )
2016
29
Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly. ( 27354743 )
2016
30
Acute Generalized Exanthematous Pustulosis Induced by Fexofenadine. ( 27057044 )
2016
31
DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case reporta8c. ( 27443659 )
2016
32
Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers. ( 27025295 )
2016
33
Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy. ( 27472323 )
2016
34
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review. ( 26273160 )
2015
35
A case of acute generalized exanthematous pustulosis associated with polyarteritis nodosa, responding to systemic steroids. ( 25846351 )
2015
36
Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis. ( 26783390 )
2015
37
Ticagrelor-induced acute generalized exanthematous pustulosis. ( 25965589 )
2015
38
Acute generalized exanthematous pustulosis possibly induced by isoniazid in a patient with psoriatic erythroderma. ( 25514351 )
2015
39
Generalized Pustulosis Diagnosed as Acute Generalized Exanthematous Pustulosis: Tzanck Smear and Pathological Evaluation of the Pustule Roof Can Provide Evidence for Early Diagnosis. ( 26512180 )
2015
40
An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis. ( 26688759 )
2015
41
Images in emergency medicine. Acute generalized exanthematous pustulosis. ( 25601249 )
2015
42
Acute generalized exanthematous pustulosis x Von Zumbusch's pustular psoriasis: A diagnostic challenge in a psoriatic patient. ( 26375226 )
2015
43
Acute generalized exanthematous pustulosis induced by celecoxib. ( 26488335 )
2015
44
Probable fenofibrate-induced acute generalized exanthematous pustulosis. ( 26581932 )
2015
45
Acute Generalized Exanthematous Pustulosis: An Uncommon Cause of Fever and Rash. ( 26231526 )
2015
46
Acute generalized exanthematous pustulosis following paracetamol ingestion in a child. ( 25845401 )
2015
47
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing. ( 26729969 )
2015
48
Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. ( 26561525 )
2015
49
First case report of acute generalized exanthematous pustulosis due to labetalol. ( 25997315 )
2015
50
Acute Generalized Exanthematous Pustulosis Due to Insect Bites? ( 26288442 )
2015

Variations for Acute Generalized Exanthematous Pustulosis

Expression for Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for Acute Generalized Exanthematous Pustulosis

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CXCL8 IL17A IL17F IL22 PTGS2
2
Show member pathways
12.83 CXCL8 IL17A IL17F IL22 PTGS2
3
Show member pathways
12.47 CXCL8 IL17A IL22
4
Show member pathways
12.19 IL17A IL17F IL22
5 11.66 CXCL8 PTGS2
6
Show member pathways
11.59 CXCL8 IL17A IL17F PTGS2
7 11.55 CXCL8 PTGS2
8 11.52 CXCL8 IL17A
9 11.45 IL17A IL22
10
Show member pathways
11.42 CXCL8 PTGS2
11
Show member pathways
11.4 CXCL8 IL17A IL17F
12
Show member pathways
11.34 IL17A IL17F IL22
13
Show member pathways
11.32 CXCL8 PTGS2
14 11.22 CXCL8 PTGS2
15 11.18 CXCL8 PTGS2
16 10.98 CXCL8 IL17A IL17F PTGS2
17 10.96 IL17A IL22
18 10.77 CXCL8 IL17A IL22
19 10.68 CXCL8 PTGS2

GO Terms for Acute Generalized Exanthematous Pustulosis

Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL8 IL17A IL17F IL22 IL36RN
2 extracellular space GO:0005615 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 CXCL8 IL17A IL36RN
2 movement of cell or subcellular component GO:0006928 9.37 CXCL8 PTGS2
3 cellular response to interleukin-1 GO:0071347 9.32 CXCL8 IL17A
4 response to glucocorticoid GO:0051384 9.26 IL22 PTGS2
5 positive regulation of interleukin-6 secretion GO:2000778 9.16 IL17A IL17F
6 inflammatory response GO:0006954 9.1 CXCL8 IL17A IL17F IL22 IL36RN PTGS2
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.96 IL17A IL17F

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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