MCID: ACT167
MIFTS: 46

Acute Generalized Exanthematous Pustulosis malady

Skin diseases, Rare diseases categories

Summaries for Acute Generalized Exanthematous Pustulosis

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Wikipedia:65 Acute generalized exanthematous pustulosis (AGEP) (also known as \"Pustular drug eruption,\" and \"Toxic... more...

MalaCards based summary: Acute Generalized Exanthematous Pustulosis, also known as agep, is related to ulcerative colitis and colitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (interleukin 36 receptor antagonist), and among its related pathways are Toll Comparative Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The compounds nonoxynol-9 and triptolide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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Sources:
49Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Acute Generalized Exanthematous Pustulosis, Aliases & Descriptions:

Name: Acute Generalized Exanthematous Pustulosis 49 62
Agep 49 62
 
Pustular Drug Eruption 49
Toxic Pustuloderma 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

49
acute generalized exanthematous pustulosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet49 293173
UMLS via Orphanet63 C0877055

Related Diseases for Acute Generalized Exanthematous Pustulosis

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Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to acute generalized exanthematous pustulosis

Symptoms for Acute Generalized Exanthematous Pustulosis

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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drug clinical trials:

Search ClinicalTrials for Acute Generalized Exanthematous Pustulosis

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

33
Testes, Skin, T cells, Myeloid, Liver, Lung, Neutrophil

Animal Models for Acute Generalized Exanthematous Pustulosis or affiliated genes

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, IL22, PTGS2
2MP:00053708.4ALB, IL22, PTGS2
3MP:00053978.3IL8, IL22, IL36RN, PTGS2
4MP:00053818.2PTGS2, IL22, ALB
5MP:00053878.2PTGS2, IL36RN, IL22, IL8
6MP:00053768.1ALB, IL22, IL36RN, PTGS2

Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50)    (show all 290)
idTitleAuthorsYear
1
Fluconazole-induced acute generalized exanthematous pustulosis. (25814733)
2015
2
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. (24888401)
2014
3
Pancreatitis-associated with riluzole; linezolid-induced hypoglycemia; sorafenib-induced acute generalized exanthematous pustulosis; creatine supplementation-induced thrombotic events; acute pancreatitis associated with quetiapine; hypomagnesemia and seizure associated with rabeprazole. (25673887)
2014
4
Acute generalized exanthematous pustulosis induced by levetiracetam. (23451808)
2014
5
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. (25030504)
2014
6
Acute generalized exanthematous pustulosis induced by ceftriaxone use. (25254014)
2014
7
Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection. (24986490)
2014
8
Midodrine-induced acute generalized exanthematous pustulosis. (24897147)
2014
9
Acute generalized exanthematous pustulosis due to dextromethorphan. (24139370)
2013
10
Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (23635939)
2013
11
Nystatin-induced acute generalized exanthematous pustulosis. (23149047)
2012
12
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient. (23304614)
2012
13
Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis. (20569282)
2011
14
Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use. (22098993)
2011
15
Clopidogrel-associated acute generalized exanthematous pustulosis. (21644491)
2011
16
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
17
Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. (21768498)
2011
18
Acute generalized exanthematous pustulosis (AGEP) caused by telavancin. (21839299)
2011
19
Acute generalized exanthematous pustulosis induced by docetaxel. (21595682)
2011
20
Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report. (21103192)
2010
21
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts. (20542841)
2010
22
Lapatinib-induced acute generalized exanthematous pustulosis. (23130185)
2010
23
Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. (20800793)
2010
24
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. (21251445)
2010
25
Acute generalized exanthematous pustulosis in a patient after stem cell transplantation. (20642988)
2010
26
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
27
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. (19663832)
2009
28
Acute generalized exanthematous pustulosis caused by varenicline. (19175479)
2009
29
Ioversol-induced acute generalized exanthematous pustulosis: a case report. (19528424)
2009
30
A case of acute generalized exanthematous pustulosis possibly induced by ritodrine. (20523816)
2009
31
Acute Generalized Exanthematous Pustulosis (AGEP) due to dapsone in a patient with leprosy. (19472855)
2009
32
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride. (18459523)
2008
33
Terbinafine-induced acute generalized exanthematous pustulosis. (18833041)
2008
34
Acute generalized exanthematous pustulosis (AGEP) due to exposure to sulfuric acid and bromic acid vapor: a case report. (18568897)
2008
35
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. (18555940)
2008
36
Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. (19123438)
2008
37
Acute generalized exanthematous pustulosis in a child. (17300662)
2007
38
Acute generalized exanthematous pustulosis caused by illicit street drugs? (17372119)
2007
39
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. (17004986)
2007
40
Severe acute generalized exanthematous pustulosis in a pregnant woman. (16855415)
2006
41
Propafenone-induced acute generalized exanthematous pustulosis. (15807741)
2005
42
Acute reversible renal failure in acute generalized exanthematous pustulosis. (12271006)
2002
43
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
44
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. (12130947)
2002
45
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. (11679003)
2001
46
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
47
Acute generalized exanthematous pustulosis with photodistribution pattern induced by sertraline. (11549814)
2001
48
Acute generalized exanthematous pustulosis due to teicoplanin. (11306839)
2001
49
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1. (9111842)
1997
50
Acute generalized exanthematous pustulosis following oral nystatin therapy: a report of three cases. (9415247)
1997

Variations for Acute Generalized Exanthematous Pustulosis

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Expression for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response MIF in innate immunity response60
9.4IL8, PTGS2
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.4PTGS2, IL8
39.4IL8, PTGS2
49.4IL8, PTGS2
5
Show member pathways
thioredoxin pathway38
9.3PTGS2, ALB
6
Show member pathways
9.1IL22, PTGS2
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0IL8, IL36RN, PTGS2
8
Show member pathways
8.6IL8, IL22, PTGS2
9
Show member pathways
8.6PTGS2, IL22, IL8

Compounds for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Compounds related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1nonoxynol-945 1310.9IL8, PTGS2
2triptolide459.8IL8, PTGS2
3parthenolide45 310.8PTGS2, IL8
4ciglitazone45 3010.8PTGS2, IL8
5sulfasalazine30 45 51 1312.8IL8, PTGS2
6ns 39845 6110.8IL8, PTGS2
7etanercept45 51 1311.8IL8, PTGS2
8fenoprofen30 45 1311.7ALB, PTGS2
9tolmetin45 1310.7ALB, PTGS2
10diflunisal45 1310.7ALB, PTGS2
11suprofen45 1310.7PTGS2, ALB
12phenylbutazone45 1310.7ALB, PTGS2
13piroxicam45 1310.7PTGS2, ALB
14etodolac45 1310.7PTGS2, ALB
15ketoprofen30 45 1311.7PTGS2, ALB
16naproxen45 26 1311.7PTGS2, ALB
1715-deoxy-delta-12,14-prostaglandin j2459.7PTGS2, IL8
18antipyrine45 1310.7ALB, PTGS2
19flurbiprofen45 30 51 1312.7ALB, PTGS2
20pdtc459.7IL8, PTGS2
21ag 1478459.7PTGS2, IL8
22sulindac45 1310.7ALB, PTGS2
23erlotinib45 51 1311.7PTGS2, ALB
24diclofenac45 30 51 1312.6ALB, PTGS2
25ibuprofen45 30 51 26 1313.6PTGS2, ALB
26salicylic acid45 3010.6ALB, PTGS2
27mifepristone45 30 61 1312.6IL8, PTGS2
28celecoxib45 61 30 51 26 1314.6ALB, PTGS2
29troglitazone45 30 61 1312.6IL8, PTGS2
30gefitinib45 51 1311.6ALB, PTGS2
31egcg459.5IL8, PTGS2
32irinotecan45 51 1311.5PTGS2, ALB
33herbimycin a45 6110.4IL8, PTGS2
34heme30 26 1311.3ALB, PTGS2
35hyaluronic acid45 2610.2ALB, IL8
36curcumin459.1IL8, PTGS2
37oxygen45 269.7PTGS2, IL22, IL8

GO Terms for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.3ALB, PTGS2
2extracellular spaceGO:00056157.8ALB, IL8, IL22, IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:00015259.4IL8, PTGS2
2cellular component movementGO:00069289.1IL8, PTGS2
3response to glucocorticoidGO:00513849.0IL22, PTGS2
4inflammatory responseGO:00069548.6IL8, IL22, PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.3ALB, PTGS2
2cytokine activityGO:00051258.9IL22, IL36RN

Products for genes affiliated with Acute Generalized Exanthematous Pustulosis

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Sources for Acute Generalized Exanthematous Pustulosis

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4CDC
15ExPASy
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24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet