MCID: ACT135
MIFTS: 55

Acute Graft Versus Host Disease malady

Blood category

Summaries for Acute Graft Versus Host Disease

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33MalaCards
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MalaCards: Acute Graft Versus Host Disease, also known as acute graft-versus-host disease, is related to graft versus host disease and acute leukemia. An important gene associated with Acute Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Malaria and Leishmaniasis. The compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are vision/eye and cellular.

Aliases & Classifications for Acute Graft Versus Host Disease

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

acute graft versus host disease 43 49
acute graft-versus-host disease 45
acute gvhd 43


External Ids:

ICD10 via Orphanet26 T86.0
SNOMED-CT via Orphanet58 402355000

Related Diseases for Acute Graft Versus Host Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the graft versus host disease family:

acute graft versus host disease chronic graft versus host disease

Diseases related to Acute Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1graft versus host disease32.5HMHA1, KIR3DL1, IL2, IL2RB, IL4, IL1R1
2acute leukemia31.4THPO, IL2, CSF3
3t-cell leukemia31.2IL2, IL2RB, IL2RA, LTA, FASLG, TNFRSF4
4vascular disease30.9IL2, IL10, FASLG, TNF
5lichen planus30.4GZMB
6peripheral t-cell lymphoma30.4IL2RB, IL2RA, LTA, GZMB
7myelodysplastic syndromes30.4THPO, KIR3DL1, FASLG, CSF3, GZMB
8pancytopenia30.4THPO, IL2RA, CSF3
9chronic myeloid leukemia30.4THPO, KIR3DL1, CSF3, GZMB
10aplastic anemia30.1THPO, FASLG, CSF3, GZMB, IFNG
11hematopoietic stem cell transplantation11.2
12acute t cell leukemia10.8
13chronic graft versus host disease10.7
14acute myeloid leukemia10.5
15bone marrow necrosis10.5
16cryptosporidiosis10.4
17acute diarrhea10.4
18blood protein disease10.4
19leukemia, t-cell, chronic10.4
20engraftment syndrome10.4
21acute monocytic leukemia10.3
22erythema multiforme10.3
23hyperprolactinemia10.3
24hypohidrosis10.3
25digeorge syndrome10.3
26alpha chain disease10.3
27amebiasis10.3
28inflammatory diarrhea10.3
29acute lymphocytic leukemia10.3
30bile duct disease10.3
31blood group incompatibility10.3
32bone development disease10.3
33splenic disease10.3
34thalassemia10.3
35demodicidosis10.3
36lymphoblastic lymphoma10.3
37malignant mesenchymal tumor10.3
38cytomegalovirus infection10.3
39leukemia, acute pre-b-cell10.3
40lip disease10.3
41acute cystitis10.1
42young syndrome10.1
43eosinophilic cystitis10.1
44lupus erythematosus10.0IL18
45purpura10.0THPO
46spondylitis10.0NOD2
47leprosy10.0IL2
48multiple myeloma10.0CSF3
49rhinitis10.0IL4
50crohn's disease10.0NOD2, TNF

Graphical network of the top 20 diseases related to Acute Graft Versus Host Disease:



Diseases related to acute graft versus host disease

Clinical Features for Acute Graft Versus Host Disease

Drugs & Therapeutics for Acute Graft Versus Host Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Acute Graft Versus Host Disease

Search NIH Clinical Center for Acute Graft Versus Host Disease

Search CenterWatch for Acute Graft Versus Host Disease

Genetic Tests for Acute Graft Versus Host Disease

Anatomical Context for Acute Graft Versus Host Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Graft Versus Host Disease:

33
Bone marrow, Whole blood, Lymph node, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Skin, Placenta, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal liver, Fetal lung

Animal Models for Acute Graft Versus Host Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Graft Versus Host Disease

Sources:
51PubMed
See all sources

Articles related to Acute Graft Versus Host Disease:

(show top 50)    (show all 664)
idTitleAuthorsYear
1
Limited benefit of pentostatin salvage therapy for steroid-refractory grade III-IV acute graft-versus-host disease. (24304375)
2013
2
A safety and feasibility study with platelet lysate expanded bone marrow mesenchymal stromal cells for the treatment of acute graft-versus-host disease in Brazil. (23844820)
2013
3
Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). (23503500)
2013
4
Diagnostic approaches for identifying acute graft-versus-host disease: what comes next? (23725276)
2013
5
Safety and efficacy of low-dose methotrexate for pediatric patients with steroid-refractory acute graft-versus-host disease after hematopoietic stem cell transplantation. (24146233)
2013
6
Treatment of severe acute graft-versus-host disease with mesenchymal stromal cells: a comparison with non-MSC treated patients. (23143687)
2012
7
Elevated Fas/FasL system and endothelial cell microparticles are involved in endothelial damage in acute graft-versus-host disease: a clinical analysis. (21917312)
2012
8
Moderate hyperprolactinemia is associated with survival in patients with acute graft-versus-host disease after allogeneic stem cell transplantation. (22664046)
2012
9
Permissive, nonpermissive HLA-DPB1 epitope disparities and the specificity of T cells infiltrating the skin during acute graft-versus-host disease. (21617014)
2011
10
Acute graft-versus-host disease following hematopoietic stem-cell transplantation. (21910799)
2011
11
Mesenchymal stem cell therapy in the treatment of acute and chronic graft versus host disease. (22655232)
2011
12
Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice. (21349838)
2011
13
Regulation of acute graft-versus-host disease by human umbilical cord blood derived stromal cells in haploidentical stem cell transplantation in mice through very late activation antigen-4. (21310663)
2011
14
Pentostatin as rescue therapy for glucocorticoid-refractory acute and chronic graft-versus-host disease. (21183872)
2010
15
Defecation of a "colon cast" as a rare presentation of acute graft-versus-host disease. (19448368)
2009
16
Mucous membrane pemphigoid with antibodies to the beta(3) subunit of Laminin 332 in a patient with acute myeloblastic leukemia and graft-versus-host disease. (19797892)
2009
17
Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin. (19838066)
2009
18
Severe acute graft versus host disease after lung transplant: report of a case successfully treated with high dose corticosteroids. (19416782)
2009
19
Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival. (18086801)
2008
20
Acute graft-versus-host disease: differing risk with differing graft sources and conditioning intensity. (18503985)
2008
21
Acute graft versus host disease following living donor liver transplantation: first Korean report. (18251173)
2007
22
Achievement of target cyclosporine concentrations as a predictor of severe acute graft versus host disease in children undergoing hematopoietic stem cell transplantation and receiving cyclosporine and methotrexate prophylaxis. (18043472)
2007
23
Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease. (18089385)
2007
24
Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (17339419)
2007
25
The influence of palifermin (Kepivance) on oral mucositis and acute graft versus host disease in patients with hematological diseases undergoing hematopoietic stem cell transplant. (17846600)
2007
26
Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease. (18022572)
2007
27
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia. (16920564)
2006
28
Vasoactive intestinal polypeptide induces regulatory dendritic cells that prevent acute graft versus host disease and leukemia relapse after bone marrow transplantation. (16888171)
2006
29
Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. (16436969)
2006
30
G-CSF-treated granulocytes inhibit acute graft-versus-host disease. (16249380)
2006
31
Pegylated TNF-alpha receptor does not prevent acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model. (17085313)
2006
32
Rituximab responsive refractory acute graft-versus-host disease. (17085314)
2006
33
Denileukin diftitox for the treatment of steroid-resistant acute graft-versus-host disease. (15744237)
2005
34
HLA-DPB1 mismatch and acute graft-versus host disease in HLA-identical sibling donors. (17977207)
2005
35
The FcgammaRIIa-polymorphic site as a potential target for acute graft-versus-host disease in allogeneic stem cell transplantation. (15744239)
2005
36
Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. (15797996)
2005
37
IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease. (15993715)
2005
38
Acute graft versus host disease after liver transplantation: patterns of lymphocyte chimerism. (16303012)
2005
39
Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation. (15908974)
2005
40
Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation. (15812393)
2005
41
IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. (14512310)
2004
42
Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. (12184912)
2002
43
Basiliximab is well tolerated and effective in the treatment of steroid-refractory acute graft-versus-host disease after allogeneic stem cell transplantation. (12476283)
2002
44
Serum TNFalpha levels in patients with acute graft-versus-host disease after bone marrow transplantation. (11455978)
2001
45
Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. (10887333)
2000
46
Tacrolimus does not abrogate the increased risk of acute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1. (10816027)
2000
47
Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease. (10607689)
2000
48
Antigenaemia during acute graft versus host disease. (7745106)
1995
49
Treatment of steroid-resistant acute graft-versus-host disease with an anti-IL-2-receptor monoclonal antibody (BT 563) in children who received T cell-depleted, partially matched, related bone marrow transplants. (8054909)
1994
50
Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease. (1596576)
1992

Genetic Variations for Acute Graft Versus Host Disease

Expression for genes affiliated with Acute Graft Versus Host Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Graft Versus Host Disease

Search GEO for disease gene expression data for Acute Graft Versus Host Disease.

Pathways for genes affiliated with Acute Graft Versus Host Disease

Sources:
30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 54Reactome, 56SinoBiological
See all sources

Pathways related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IL18
2
Hide members
10.5IL18, NOD2
3
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10.5IL1R1, GZMB
410.4IL18, IL15
5
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10.4IL2RA, IFNG, IL2, IL2RB
610.4IL18, IL2, IFNG, IL2RA
710.4IL18, TNF, IFNG
8
Development Thrombopoetin signaling via JAK-STAT pathway
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10.4IFNG, IL4, THPO
9
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10.4TNF, IL1R1, NOD2, IL18
10
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10.4IL4, IFNG, IL2
11
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10.4IL2RA, NOD2, IL2, IL2RB, IL1R1, IL18
12
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10.4THPO, IL2, LTA, IL2RB, IL2RA
1310.4IFNG, IL2, TNF
1410.4IL2RA, IFNG, IL2, IL4, IL2RB
15
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10.4IL1R1, LTA, TNFRSF4, TNF
16
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10.4THPO, TNF, IL1R1, LTA
17
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10.4LTA, TNF, TNFRSF4, FASLG
1810.4IL1R1, IL4, TNF, IL2
1910.4IL1R1, IFNG, IL10, TNF
2010.4IL18, IL10, NOD2, TNF, IFNG
2110.4LTA, TNF, NOD2, IL15
22
Hide members
10.4TNFRSF4, THPO, IL2RB, LTA, IL15, IL18
23
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10.4FASLG, TNF, LTA, IL1R1
24
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10.4IL2, NOD2, IL1R1, IL2RB, IL18, IL2RA
25
Immune response Bacterial infections in normal airways
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10.4IFNG, TNF, IL1R1, FASLG
26
Development PDGF signaling via STATs and NF-kB
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10.4IL2, TNF, IL10, IL18, IFNG
27
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10.4IL2, IL2RB, IL4, IL2RA, LTA, FASLG
28
Hide members
10.4IL15, IL2RA, FASLG, TNFRSF4, CSF3
2910.4TNF, FASLG, IL10, IL18, IFNG
3010.4IL2, GZMB, FASLG, IL2RA, IL10, IL2RB
31
Hide members
10.4FASLG, TNF, LTA, GZMB, IL1R1
3210.4IL2RA, IL2, IL4, IL2RB, FASLG, CSF3
33
Hide members
10.4IFNG, IL2, IL10, FASLG, TNF
3410.4IFNG, IL2, IL4, IL10, LTA, TNFRSF4
3510.4THPO, IL4, IL1R1, CSF3, TNF, IL2RA
36
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10.4IL2, IL18, IL10, IFNG, TNF, LTA
37
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10.4IFNG, IL4, IL2, IL2RA, TNF, FASLG
38
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10.4IL15, LTA, IL2RB, IL1R1, IL2RA, TNFRSF4
39
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10.4IFNG, TNF, IL2RA, IL2, IL4, IL2RB
4010.4LTA, IL2RA, IL15, IL1R1, IL2, IL2RB
4110.4IFNG, GZMB, TNF, IL2, IL2RB, IL2RA
42
Hide members
10.4GZMB, FASLG, IL2RA, IL18, IL1R1, IL4
43
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10.4TNF, IL4, IL2, FASLG, KIR3DL1, GZMB
44
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10.4IL2, TNF, LTA, IL2RA, IL15, IL4
4510.4IFNG, CSF3, IL2RA, IL15, IL10, IL2
46
Hide members
10.4GZMB, TNF, FASLG, IL2RA, IL15, IL10
4710.4TNF, LTA, IL15, IL10, IL18, IL4
48
Hide members
10.3IFNG, TNF, FASLG, LTA, IL2RA, IL15
49
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10.3TNF, FASLG, GZMB, IFNG, LTA, IL2RA
50
Hide members
10.3IL4, CSF3, IL1R1, IL18, IL10, IL15

Compounds for genes affiliated with Acute Graft Versus Host Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1pge24510.9IL2
2gm-csf45 2911.9IFNG, TNF, IL10, THPO
3ivig4510.9IFNG, IL1R1, IL2RB
4endotoxin4510.9CSF3, FASLG
5prednisolone45 29 1112.8GZMB, LTA, IL2RA, IL1R1, IL2RB, NOD2
6indomethacin45 60 29 1113.8IL1R1
7pentoxifylline45 1111.8AMBP, LTA, IL18, IL1R1, IL4, IL2RB
8etanercept45 50 1112.8IL1R1, LTA, TNF, IFNG, IL15, IL10
9cyclophosphamide45 50 1112.8CSF3, FASLG, IL2RA, IL15, IL1R1, IL2RB
10cycloheximide4510.8FASLG, IL2RB, LTA, IL18
11dexamethasone45 50 29 1113.8IL1R1, IL15, GZMB, FASLG, LTA
12rapamycin4510.8THPO, IFNG, GZMB, FASLG, IL2RA, IL15
13tacrolimus45 50 1112.8IFNG, GZMB, TNF, FASLG, IL2RA, IL15
14cyclosporin a45 29 6012.8AMBP, IFNG, GZMB, CSF3, TNFRSF4, LTA
15okt34510.8IL2RB, IL2, IL4, IL10, IL15, IFNG
16infliximab45 50 1112.8IL18, IL2RB, NOD2, IL4, IL1R1, IL10
17con a4510.8IL2RA, IL10, IFNG, IL4, IL2RB, IL2
18alpha-galactosylceramide4510.8IL2, IL10, IL4, IL15, GZMB, IFNG
19il 104510.8IL2, NOD2, IL2RB, IL4, IL1R1, IFNG
20ionomycin4510.8IFNG, TNF, TNFRSF4, FASLG, LTA, IL2RA
21il-124510.7IL4, IL1R1, IL18, IL10, IL15, TNF
22neopterin4510.7GZMB, TNF, LTA, IL2RA, IL10, IL18
23rituximab45 50 1112.7IL1R1, IL2, IL15, IL10, IL2RA, FASLG
24thalidomide45 50 60 1113.7IL18, IL2RA, IL1R1, IL2, FASLG, TNF
25mycophenolate mofetil45 50 1112.7IFNG, CSF3, IL2RA, IL10, IL18, IL2RB
26chloroquine45 2 50 29 1114.7IL4, IL2, TNF, IL1R1, IL18, IL10
27polyinosinic-polycytidylic acid4510.7IL10, IL18, IL4, IL15, TNF, IFNG
28vegf4510.7IL2RA, IL15, IL10, IL18, IL1R1, IL2RB
29thymidine45 2411.7TNF, IFNG, CSF3, FASLG, IL2RA, IL15
30ifn-alpha4510.7IL2RB, IL18, IL2, FASLG, IL2RA, IL10
31rantes4510.7IFNG, GZMB, CSF3, TNF, FASLG, LTA
32histamine45 29 2412.7IL2RB, IL4, IFNG, TNF, IL2RA, IL15
33interferon gamma4510.7TNF, IL2, IL4, IL10, IFNG
34c-d4t4510.7IL15, IL2, IL4, IL2RA, FASLG
35methotrexate45 50 1112.7IL15, IL2RA, FASLG, TNF, CSF3, IL10
36ccl345 2911.7IL1R1, IFNG, IL18, CSF3, IL15, TNF
372,5-oligoadenylate4510.7TNF, IL2RA, IL10, IL2RB, IL2, IFNG
38nitric oxide45 11 2412.6IL15, THPO, IFNG, NOD2, IL10, FASLG
39gold sodium thiomalate4510.6IL2, IFNG, IL1R1, IL2RA, TNF
40tuberculin4510.6IL18, IL10, IL15, IL2RA, IFNG
415fluorouracil4510.6CSF3, IL2, THPO, IL15, IL18, IFNG
42natalizumab45 1111.6IL2RA, IL10, IL18, IFNG, TNF
43retinoic acid45 2411.6CSF3, IL18, IL15, AMBP, LTA, FASLG
44ribavirin45 50 1112.5IFNG, CSF3, IL10, IL2, IL18, IL4
45chromium4510.5IL2RB, KIR3DL1, GZMB
46lactate4510.5IL2RB, LTA, FASLG, THPO, AMBP, TNF
47sb 20358045 6011.4FASLG, IL10, IL18, IL1R1, IL4, THPO
48cisplatin45 50 60 1113.4IL2RB, IL18, IL2RA, FASLG, CSF3, GZMB
49tgf beta14510.3IL15, TNF, IL10, IL18, THPO, FASLG
50tyrosine4510.0GZMB, KIR3DL1, FASLG, CSF3, LTA, IL2RA

GO Terms for genes affiliated with Acute Graft Versus Host Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4IFNG, TNF, TNFRSF4, FASLG, IL2RA, IL4
2integral to plasma membraneGO:00588710.4TNFRSF4, FASLG, IL15, IL1R1, IL2RB, KIR3DL1
3extracellular spaceGO:00561510.3THPO, AMBP, IFNG, CSF3, TNF, FASLG
4cell surfaceGO:00998610.3AMBP, TNF, TNFRSF4, IL1R1, NOD2
5extracellular regionGO:00557610.0AMBP, IFNG, TNF, FASLG, IL15, IL18

Biological processes related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1type 2 immune responseGO:04209210.9IL10, IL18, IL4
2positive regulation of activated T cell proliferationGO:04210410.9IL2, IL4, IL18, IL2RA
3positive regulation of interleukin-17 productionGO:03274010.9IL15, IL18, IL2, NOD2
4regulation of T cell homeostatic proliferationGO:04601310.9IL2RA, IL2
5positive regulation of tissue remodelingGO:03410510.9IL15, IL18, IL2
6positive regulation of isotype switching to IgG isotypesGO:04830410.8IFNG, IL4, IL2
7positive regulation of interferon-gamma productionGO:03272910.8IL2, IL18, LTA, TNF
8positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA, NOD2
9positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10, IL4
10negative regulation of growth of symbiont in hostGO:04413010.8IFNG, TNF, LTA, IL10, NOD2
11positive regulation of vitamin D biosynthetic processGO:06055710.8IFNG, TNF
12positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.8TNF, LTA
13positive regulation of chemokine biosynthetic processGO:04508010.8IL4, TNF, IFNG
14positive regulation of tumor necrosis factor productionGO:03276010.8NOD2, IL18, IFNG
15positive regulation of B cell proliferationGO:03089010.8TNFRSF4, IL4, IL2
16cell-cell signalingGO:00726710.8FASLG, LTA, IL15, IL10, IL18, IL2
17regulation of isotype switchingGO:04519110.8IL10, IL4
18positive regulation of calcidiol 1-monooxygenase activityGO:06055910.8IFNG, TNF
19defense response to Gram-positive bacteriumGO:05083010.8TNF, LTA, NOD2
20activation of necroptosis by extracellular signalsGO:06055510.8TNF, FASLG
21inflammatory responseGO:00695410.8TNF, TNFRSF4, IL15, IL10, IL18
22response to drugGO:04249310.8IFNG, TNF, LTA, IL10, IL4
23receptor biosynthetic processGO:03280010.8TNF, IL10
24immune responseGO:00695510.8KIR3DL1, CSF3, TNFRSF4, FASLG, IL2RA, IL15
25innate immune response in mucosaGO:00222710.8IL4, NOD2
26positive regulation of neuron apoptotic processGO:04352510.8IL18, FASLG, TNF
27humoral immune responseGO:00695910.8IFNG, TNF, LTA
28positive regulation of inflammatory responseGO:05072910.7IL15, IL18, IL2
29apoptotic processGO:00691510.7IFNG, GZMB, TNF, FASLG, LTA, IL2RA
30positive regulation of T cell proliferationGO:04210210.7IL4, IL15, IFNG
31necrotic cell deathGO:07026510.7TNF, FASLG
32negative regulation of cytokine secretion involved in immune responseGO:00274010.7TNF, IL10
33positive regulation of natural killer cell proliferationGO:03281910.7IL18, IL15
34positive regulation of immunoglobulin secretionGO:05102410.7TNFRSF4, IL2
35positive regulation of transcription from RNA polymerase II promoterGO:04594410.7IFNG, CSF3, TNF, IL10, IL4, IL2
36response to nutrientGO:00758410.7NOD2, IL4, LTA
37positive regulation of interleukin-1 beta productionGO:03273110.6IL18, NOD2
38cellular response to lipopolysaccharideGO:07122210.6IL10, CSF3, IFNG
39negative regulation of immune responseGO:05077710.6IL2RA, AMBP
40positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL4, IL10, TNF
41positive regulation of apoptotic processGO:04306510.5TNF, FASLG, LTA, IL2RA
42negative regulation of interleukin-12 productionGO:03269510.5IL10, NOD2
43negative regulation of nitric oxide biosynthetic processGO:04501910.5IL4, IL10
44lymph node developmentGO:04853510.3IL15, LTA
45positive regulation of T cell differentiationGO:04558210.2IL2RA, IL4

Molecular functions related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:01997610.5IL2RB, IL2RA
2growth factor activityGO:00808310.4CSF3, IL10, IL4, IL2, THPO
3cytokine activityGO:00512510.4THPO, IFNG, CSF3, TNF, FASLG, LTA
4tumor necrosis factor receptor bindingGO:00516410.3LTA, FASLG, TNF
5interleukin-2 receptor activityGO:00491110.2IL2RB, IL2RA

Products for genes affiliated with Acute Graft Versus Host Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Graft Versus Host Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet