MCID: ACT135
MIFTS: 46

Acute Graft Versus Host Disease malady

Blood diseases category

Summaries for Acute Graft Versus Host Disease

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MalaCards: Acute Graft Versus Host Disease, also known as acute graft-versus-host disease, is related to graft versus host disease and acute leukemia. An important gene associated with Acute Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Malaria and Leishmaniasis. The compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related mouse phenotypes are vision/eye and cellular.

Aliases & Classifications for Acute Graft Versus Host Disease

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42NIH Rare Diseases, 48Orphanet, 44Novoseek, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

acute graft versus host disease 42 48
acute graft-versus-host disease 44
acute gvhd 42


External Ids:

ICD10 via Orphanet26 T86.0
SNOMED-CT via Orphanet57 402355000

Related Diseases for Acute Graft Versus Host Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graft Versus Host Disease family:

acute graft versus host disease Chronic Graft Versus Host Disease

Diseases related to Acute Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 268)
idRelated DiseaseScoreTop Affiliating Genes
1graft versus host disease32.5HMHA1, KIR3DL1, IL2, IL2RB, IL4, IL1R1
2acute leukemia31.3THPO, IL2, CSF3
3leukemia31.3THPO, HMHA1, KIR3DL1, IL2, IL2RB, IL4
4skin disease31.2IL4, IL18, IL10, TNF, IFNG
5vascular disease30.8IL2, IL10, FASLG, TNF
6myeloid leukemia30.7THPO, KIR3DL1, LTA, CSF3
7eosinophilia30.7IL2, IL2RB, IL4, IL18, IL10, IL2RA
8diarrhea30.6IL2
9t-cell leukemia30.6IL2, IL2RB, IL2RA, LTA, FASLG, TNFRSF4
10hepatitis30.6THPO, IL2RB, FASLG, GZMB
11lichen planus30.4GZMB
12pneumonia30.4IL2RB, IL10, TNF, CSF3
13obesity30.4IL18, IL15, TNF
14neutropenia30.4THPO, CSF3, GZMB
15severe combined immunodeficiency30.4IL2, IL2RB, IL4, IL15, IL2RA, IFNG
16lymphopenia30.4IL2, IL2RB, IL4, IL18, IL10, IL15
17pancytopenia30.4THPO, IL2RA, CSF3
18monocytic leukemia30.4IL1R1, TNF, IFNG
19chronic lymphocytic leukemia30.4THPO, IL2, IL4, IL2RA, LTA
20chronic myeloid leukemia30.4THPO, KIR3DL1, CSF3, GZMB
21aplastic anemia30.0THPO, FASLG, CSF3, GZMB, IFNG
22liver disease10.9
23intestinal disease10.7
24leukocyte disease10.7
25colonic disease10.6
26acute myeloid leukemia10.5
27cryptosporidiosis10.4
28acute diarrhea10.4
29acute t cell leukemia10.4
30acute lymphocytic leukemia10.4
31blood protein disease10.4
32lymphoblastic leukemia10.4
33pancreas disease10.4
34acute monocytic leukemia10.3
35erythema multiforme10.3
36hyperprolactinemia10.3
37hypohidrosis10.3
38digeorge syndrome10.3
39alpha chain disease10.3
40amebiasis10.3
41inflammatory diarrhea10.3
42bile duct disease10.3
43blood group incompatibility10.3
44bone development disease10.3
45central nervous system disease10.3
46chromosomal disease10.3
47common bile duct disease10.3
48hemorrhagic disease10.3
49hyperglycemia10.3
50kidney disease10.3

Graphical network of the top 20 diseases related to Acute Graft Versus Host Disease:



Diseases related to acute graft versus host disease

Clinical Features for Acute Graft Versus Host Disease

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Drugs & Therapeutics for Acute Graft Versus Host Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Acute Graft Versus Host Disease

Search NIH Clinical Center for Acute Graft Versus Host Disease

Search CenterWatch for Acute Graft Versus Host Disease

Genetic Tests for Acute Graft Versus Host Disease

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Anatomical Context for Acute Graft Versus Host Disease

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32MalaCards
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MalaCards organs/tissues related to Acute Graft Versus Host Disease:

32
Bone, Bone marrow

Animal Models for Acute Graft Versus Host Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Graft Versus Host Disease:

36 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.6IL1R1
2MP:000538410.6GZMB, TNF, TNFRSF4, FASLG, LTA, IL2RA
3MP:000538810.6TNFRSF4, FASLG, LTA, IL1R1
4MP:000538110.6FASLG, TNFRSF4, TNF, IFNG, IL2RA, IL10
5MP:000537010.6IFNG, TNF, TNFRSF4, FASLG, LTA, IL10
6MP:000537910.6AMBP, IFNG, TNF, FASLG, LTA, IL1R1
7MP:000537810.6IL2RA, LTA, TNFRSF4, TNF, IFNG, IL15
8MP:000539710.6NOD2, IFNG, GZMB, CSF3, TNF, TNFRSF4
9MP:000538910.6AMBP, FASLG, IL15, IL2RB
10MP:000538710.6LTA, FASLG, TNFRSF4, TNF, CSF3, GZMB
11MP:001076810.5IL2RA, LTA, FASLG, TNF, GZMB, IFNG
12MP:000200610.5IFNG, TNF, FASLG, IL10, IL1R1, IL2
13MP:000539010.5FASLG, LTA, IL4, NOD2
14MP:000538610.3IFNG, TNF, LTA, IL10, IL18, IL1R1
15MP:001077110.3IL1R1, FASLG
16MP:000538510.3IFNG, TNF, FASLG, LTA, IL15, IL10
17MP:000537610.1IFNG, LTA, IL18, IL1R1, IL4, IL2

Publications for Acute Graft Versus Host Disease

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Genetic Variations for Acute Graft Versus Host Disease

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Expression for genes affiliated with Acute Graft Versus Host Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Graft Versus Host Disease

Search GEO for disease gene expression data for Acute Graft Versus Host Disease.

Pathways for genes affiliated with Acute Graft Versus Host Disease

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome, 55SinoBiological
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Pathways related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IL18
2
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10.5IL18, NOD2
3
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10.5IL1R1, GZMB
410.4IL15, IL18
5
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10.4IFNG, IL2RA, IL2RB, IL2
610.4IL2, IL18, IL2RA, IFNG
710.4IL18, TNF, IFNG
8
Development Thrombopoetin signaling via JAK-STAT pathway
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10.4THPO, IL4, IFNG
9
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10.4TNF, IL18, IL1R1, NOD2
10
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10.4IL2, IL4, IFNG
11
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10.4IL2RA, IL18, IL1R1, IL2RB, IL2, NOD2
12
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10.4LTA, IL2RA, IL2RB, IL2, THPO
1310.4IFNG, TNF, IL2
1410.4IL2, IL2RB, IL4, IL2RA, IFNG
15
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10.4TNF, TNFRSF4, LTA, IL1R1
16
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10.4TNF, LTA, IL1R1, THPO
17
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10.4LTA, FASLG, TNFRSF4, TNF
1810.4TNF, IL1R1, IL4, IL2
1910.4IL1R1, IL10, TNF, IFNG
2010.4IFNG, TNF, IL10, IL18, NOD2
2110.4TNF, LTA, IL15, NOD2
22
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10.4TNFRSF4, LTA, IL15, IL18, IL2RB, THPO
23
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10.4IL1R1, LTA, FASLG, TNF
24
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10.4IFNG, IL2RA, IL18, IL1R1, IL2RB, IL2
25
Immune response Bacterial infections in normal airways
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10.4IL1R1, FASLG, TNF, IFNG
26
Development PDGF signaling via STATs and NF-kB
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10.4IFNG, TNF, IL10, IL18, IL2
27
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10.4FASLG, LTA, IL2RA, IL4, IL2RB, IL2
28
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10.4CSF3, TNFRSF4, FASLG, IL2RA, IL15
2910.4IFNG, TNF, FASLG, IL10, IL18
3010.4GZMB, FASLG, IL2RA, IL10, IL4, IL2RB
31
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10.4IL1R1, LTA, FASLG, TNF, GZMB
3210.4CSF3, FASLG, IL2RA, IL4, IL2RB, IL2
33
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10.4IL2, IL10, FASLG, TNF, IFNG
3410.4IFNG, TNFRSF4, LTA, IL10, IL4, IL2
3510.4CSF3, TNF, IL2RA, IL1R1, IL4, THPO
36
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10.4IFNG, TNF, LTA, IL10, IL18, IL2
37
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10.4IFNG, TNF, FASLG, IL2RA, IL4, IL2
38
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10.4CSF3, TNFRSF4, LTA, IL2RA, IL15, IL1R1
39
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10.4IFNG, TNF, IL2RA, IL1R1, IL4, IL2RB
4010.4TNF, LTA, IL2RA, IL15, IL1R1, IL2RB
4110.4IFNG, GZMB, TNF, TNFRSF4, FASLG, IL2RA
42
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10.4FASLG, IL2RA, IL18, IL1R1, IL4, IL2RB
43
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10.4IFNG, GZMB, TNF, FASLG, IL4, IL2
44
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10.4TNF, LTA, IL2RA, IL15, IL4, IL2RB
4510.4IFNG, CSF3, IL2RA, IL15, IL10, IL4
46
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10.4IFNG, GZMB, TNF, FASLG, IL2RA, IL15
4710.4IFNG, TNF, LTA, IL15, IL10, IL18
48
Hide members
10.3IFNG, TNF, FASLG, LTA, IL2RA, IL15
49
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10.3IFNG, GZMB, TNF, FASLG, LTA, IL2RA
50
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10.3IL2RB, IL2, THPO, IL4, IL1R1, IL18

Compounds for genes affiliated with Acute Graft Versus Host Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1pge24410.9IL2
2gm-csf44 2811.9IFNG, TNF, IL10, THPO
3ivig4410.9IFNG, IL1R1, IL2RB
4endotoxin4410.9CSF3, FASLG
5prednisolone44 28 1112.8GZMB, LTA, IL2RA, IL1R1, IL2RB, NOD2
6indomethacin44 59 28 1113.8IL1R1
7pentoxifylline44 1111.8AMBP, LTA, IL18, IL1R1, IL4, IL2RB
8etanercept44 49 1112.8IL1R1, LTA, TNF, IFNG, IL15, IL10
9cyclophosphamide44 49 1112.8CSF3, FASLG, IL2RA, IL15, IL1R1, IL2RB
10cycloheximide4410.8FASLG, IL2RB, LTA, IL18
11dexamethasone44 49 28 1113.8IL1R1, IL15, GZMB, FASLG, LTA
12rapamycin4410.8THPO, IFNG, GZMB, FASLG, IL2RA, IL15
13tacrolimus44 49 1112.8IFNG, GZMB, TNF, FASLG, IL2RA, IL15
14cyclosporin a44 28 5912.8AMBP, IFNG, GZMB, CSF3, TNFRSF4, LTA
15okt34410.8IL2RB, IL2, IL4, IL10, IL15, IFNG
16infliximab44 49 1112.8IL18, IL2RB, NOD2, IL4, IL1R1, IL10
17con a4410.8IL2RA, IL10, IFNG, IL4, IL2RB, IL2
18alpha-galactosylceramide4410.8IL2, IL10, IL4, IL15, GZMB, IFNG
19il 104410.8IL2, NOD2, IL2RB, IL4, IL1R1, IFNG
20ionomycin4410.8IFNG, TNF, TNFRSF4, FASLG, LTA, IL2RA
21il-124410.7IL4, IL1R1, IL18, IL10, IL15, TNF
22neopterin4410.7GZMB, TNF, LTA, IL2RA, IL10, IL18
23rituximab44 49 1112.7IL1R1, IL2, IL15, IL10, IL2RA, FASLG
24thalidomide44 49 59 1113.7IL18, IL2RA, IL1R1, IL2, FASLG, TNF
25mycophenolate mofetil44 49 1112.7IFNG, CSF3, IL2RA, IL10, IL18, IL2RB
26chloroquine44 2 49 28 1114.7IL4, IL2, TNF, IL1R1, IL18, IL10
27polyinosinic-polycytidylic acid4410.7IL10, IL18, IL4, IL15, TNF, IFNG
28vegf4410.7IL2RA, IL15, IL10, IL18, IL1R1, IL2RB
29thymidine44 2411.7TNF, IFNG, CSF3, FASLG, IL2RA, IL15
30ifn-alpha4410.7IL2RB, IL18, IL2, FASLG, IL2RA, IL10
31rantes4410.7IFNG, GZMB, CSF3, TNF, FASLG, LTA
32histamine44 28 2412.7IL2RB, IL4, IFNG, TNF, IL2RA, IL15
33interferon gamma4410.7TNF, IL2, IL4, IL10, IFNG
34c-d4t4410.7IL15, IL2, IL4, IL2RA, FASLG
35methotrexate44 49 1112.7IL15, IL2RA, FASLG, TNF, CSF3, IL10
36ccl344 2811.7IL1R1, IFNG, IL18, CSF3, IL15, TNF
372,5-oligoadenylate4410.7TNF, IL2RA, IL10, IL2RB, IL2, IFNG
38nitric oxide44 11 2412.6IL15, THPO, IFNG, NOD2, IL10, FASLG
39gold sodium thiomalate4410.6IL2, IFNG, IL1R1, IL2RA, TNF
40tuberculin4410.6IL18, IL10, IL15, IL2RA, IFNG
415fluorouracil4410.6CSF3, IL2, THPO, IL15, IL18, IFNG
42natalizumab44 1111.6IL2RA, IL10, IL18, IFNG, TNF
43retinoic acid44 2411.6CSF3, IL18, IL15, AMBP, LTA, FASLG
44ribavirin44 49 1112.5IFNG, CSF3, IL10, IL2, IL18, IL4
45chromium4410.5IL2RB, KIR3DL1, GZMB
46lactate4410.5IL2RB, LTA, FASLG, THPO, AMBP, TNF
47sb 20358044 5911.4FASLG, IL10, IL18, IL1R1, IL4, THPO
48cisplatin44 49 59 1113.4IL2RB, IL18, IL2RA, FASLG, CSF3, GZMB
49tgf beta14410.3IL15, TNF, IL10, IL18, THPO, FASLG
50tyrosine4410.0GZMB, KIR3DL1, FASLG, CSF3, LTA, IL2RA

GO Terms for genes affiliated with Acute Graft Versus Host Disease

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16Gene Ontology
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Cellular components related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4IFNG, TNF, TNFRSF4, FASLG, IL2RA, IL4
2integral to plasma membraneGO:00588710.4TNFRSF4, FASLG, IL15, IL1R1, IL2RB, KIR3DL1
3extracellular spaceGO:00561510.3THPO, AMBP, IFNG, CSF3, TNF, FASLG
4cell surfaceGO:00998610.3AMBP, TNF, TNFRSF4, IL1R1, NOD2
5extracellular regionGO:00557610.0AMBP, IFNG, TNF, FASLG, IL15, IL18

Biological processes related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1type 2 immune responseGO:04209210.9IL10, IL18, IL4
2positive regulation of activated T cell proliferationGO:04210410.9IL2, IL4, IL18, IL2RA
3positive regulation of interleukin-17 productionGO:03274010.9IL15, IL18, IL2, NOD2
4regulation of T cell homeostatic proliferationGO:04601310.9IL2RA, IL2
5positive regulation of tissue remodelingGO:03410510.9IL15, IL18, IL2
6positive regulation of isotype switching to IgG isotypesGO:04830410.8IFNG, IL4, IL2
7positive regulation of interferon-gamma productionGO:03272910.8IL2, IL18, LTA, TNF
8positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA, NOD2
9positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10, IL4
10negative regulation of growth of symbiont in hostGO:04413010.8IFNG, TNF, LTA, IL10, NOD2
11positive regulation of vitamin D biosynthetic processGO:06055710.8IFNG, TNF
12positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.8TNF, LTA
13positive regulation of chemokine biosynthetic processGO:04508010.8IL4, TNF, IFNG
14positive regulation of tumor necrosis factor productionGO:03276010.8NOD2, IL18, IFNG
15positive regulation of B cell proliferationGO:03089010.8TNFRSF4, IL4, IL2
16cell-cell signalingGO:00726710.8FASLG, LTA, IL15, IL10, IL18, IL2
17regulation of isotype switchingGO:04519110.8IL10, IL4
18positive regulation of calcidiol 1-monooxygenase activityGO:06055910.8IFNG, TNF
19defense response to Gram-positive bacteriumGO:05083010.8TNF, LTA, NOD2
20activation of necroptosis by extracellular signalsGO:06055510.8TNF, FASLG
21inflammatory responseGO:00695410.8TNF, TNFRSF4, IL15, IL10, IL18
22response to drugGO:04249310.8IFNG, TNF, LTA, IL10, IL4
23receptor biosynthetic processGO:03280010.8TNF, IL10
24immune responseGO:00695510.8KIR3DL1, CSF3, TNFRSF4, FASLG, IL2RA, IL15
25innate immune response in mucosaGO:00222710.8IL4, NOD2
26positive regulation of neuron apoptotic processGO:04352510.8IL18, FASLG, TNF
27humoral immune responseGO:00695910.8IFNG, TNF, LTA
28positive regulation of inflammatory responseGO:05072910.7IL15, IL18, IL2
29apoptotic processGO:00691510.7IFNG, GZMB, TNF, FASLG, LTA, IL2RA
30positive regulation of T cell proliferationGO:04210210.7IL4, IL15, IFNG
31necrotic cell deathGO:07026510.7TNF, FASLG
32negative regulation of cytokine secretion involved in immune responseGO:00274010.7TNF, IL10
33positive regulation of natural killer cell proliferationGO:03281910.7IL18, IL15
34positive regulation of immunoglobulin secretionGO:05102410.7TNFRSF4, IL2
35positive regulation of transcription from RNA polymerase II promoterGO:04594410.7IFNG, CSF3, TNF, IL10, IL4, IL2
36response to nutrientGO:00758410.7NOD2, IL4, LTA
37positive regulation of interleukin-1 beta productionGO:03273110.6IL18, NOD2
38cellular response to lipopolysaccharideGO:07122210.6IL10, CSF3, IFNG
39negative regulation of immune responseGO:05077710.6IL2RA, AMBP
40positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL4, IL10, TNF
41positive regulation of apoptotic processGO:04306510.5TNF, FASLG, LTA, IL2RA
42negative regulation of interleukin-12 productionGO:03269510.5IL10, NOD2
43negative regulation of nitric oxide biosynthetic processGO:04501910.5IL4, IL10
44lymph node developmentGO:04853510.3IL15, LTA
45positive regulation of T cell differentiationGO:04558210.2IL2RA, IL4

Molecular functions related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:01997610.5IL2RB, IL2RA
2growth factor activityGO:00808310.4CSF3, IL10, IL4, IL2, THPO
3cytokine activityGO:00512510.4THPO, IFNG, CSF3, TNF, FASLG, LTA
4tumor necrosis factor receptor bindingGO:00516410.3LTA, FASLG, TNF
5interleukin-2 receptor activityGO:00491110.2IL2RB, IL2RA

Products for genes affiliated with Acute Graft Versus Host Disease

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Sources for Acute Graft Versus Host Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet