MCID: ACT135
MIFTS: 50

Acute Graft Versus Host Disease malady

Rare diseases, Blood diseases categories

Summaries for Acute Graft Versus Host Disease

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34MalaCards
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MalaCards: Acute Graft Versus Host Disease, also known as acute graft-versus-host disease, is related to graft versus host disease and eosinophilia. An important gene associated with Acute Graft Versus Host Disease is IL18 (interleukin 18 (interferon-gamma-inducing factor)), and among its related pathways are IL12-mediated signaling events and Salmonella infection. The compounds interferon gamma and anakinra have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related mouse phenotypes are cardiovascular system and integument.

Aliases & Classifications for Acute Graft Versus Host Disease

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

acute graft versus host disease 44 50
acute graft-versus-host disease 46
acute gvhd 44


External Ids:

ICD10 via Orphanet27 T86.0
SNOMED-CT via Orphanet60 402355000

Related Diseases for Acute Graft Versus Host Disease

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18GeneCards, 19GeneDecks
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Diseases in the Graft Versus Host Disease family:

acute graft versus host disease Chronic Graft Versus Host Disease

Diseases related to Acute Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1graft versus host disease32.4IL18, IFNG, TNF, UGT2B17
2eosinophilia30.8IFNG, IL18
3pneumonia30.6TNF
4lymphopenia30.5IL18, IFNG
5monocytic leukemia30.5IFNG, TNF
6hematopoietic stem cell transplantation11.2
7leukemia10.9
8endotheliitis10.8
9myeloid leukemia10.5
10cryptosporidiosis10.4
11acute myeloid leukemia10.4
12diarrhea10.4
13hepatitis10.4
14lymphoblastic leukemia10.4
15chronic graft versus host disease10.4
16engraftment syndrome10.4
17amebiasis10.3
18lichen planus10.3
19chronic myeloid leukemia10.3
20erythema multiforme10.3
21hyperprolactinemia10.3
22hypohidrosis10.3
23digeorge syndrome10.3
24pancytopenia10.3
25blood group incompatibility10.3
26hyperglycemia10.3
27myopathy10.3
28neutropenia10.3
29obesity10.3
30prolymphocytic leukemia10.3
31severe combined immunodeficiency10.3
32thalassemia10.3
33b-cell lymphomas10.3
34demodicidosis10.3
35lymphoblastic lymphoma10.3
36malignant mesenchymal tumor10.3
37myelodysplastic syndromes10.3
38cytomegalovirus infection10.3
39blindness10.3
40schnitzler syndrome10.1CD40LG
41hemorrhagic fever10.1CD40LG
42leishmaniasis10.1IFNG
43scrub typhus10.1CD40LG
44hemorrhagic cystitis10.1
45aplastic anemia10.1
46cystitis10.1
47eosinophilic cystitis10.1
48pleural tuberculosis10.1IL18, IFNG
49relapsing-remitting multiple sclerosis10.1IL18, IFNG
50plasmodium falciparum malaria10.1IFNG, IL18

Graphical network of the top 20 diseases related to Acute Graft Versus Host Disease:



Diseases related to acute graft versus host disease

Symptoms for Acute Graft Versus Host Disease

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Drugs & Therapeutics for Acute Graft Versus Host Disease

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Acute Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Acute Graft Versus Host Disease

Search NIH Clinical Center for Acute Graft Versus Host Disease

Search CenterWatch for Acute Graft Versus Host Disease

Genetic Tests for Acute Graft Versus Host Disease

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Anatomical Context for Acute Graft Versus Host Disease

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34MalaCards
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MalaCards organs/tissues related to Acute Graft Versus Host Disease:

34
T cells, Bone, Bone marrow, Liver, Skin, Endothelial, Myeloid, B cells, Lung, Colon, Pancreas, Testes, Monocytes, Lymph node, Kidney, Heart

Animal Models for Acute Graft Versus Host Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acute Graft Versus Host Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3CD40LG, IL18, IFNG, TNF
2MP:00107718.0CD40LG, IL18, IFNG, TNF

Publications for Acute Graft Versus Host Disease

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53PubMed
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Articles related to Acute Graft Versus Host Disease:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Limited benefit of pentostatin salvage therapy for steroid-refractory grade III-IV acute graft-versus-host disease. (24304375)
2013
2
Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. (24248672)
2013
3
A safety and feasibility study with platelet lysate expanded bone marrow mesenchymal stromal cells for the treatment of acute graft-versus-host disease in Brazil. (23844820)
2013
4
Many days at home during neutropenia after allogeneic hematopoietic stem cell transplantation correlates with low incidence of acute graft-versus-host disease. (23089563)
2013
5
Recent compounds for immunosuppression and experimental therapies for acute graft-versus-host disease. (23484241)
2013
6
Current practice in diagnosis and treatment of acute graft-versus-host disease: results from a survey among German-Austrian-Swiss hematopoietic stem cell transplant centers. (23376495)
2013
7
Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation. (24040397)
2013
8
Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. (23694951)
2013
9
Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. (22371885)
2012
10
Potential biomarkers for early detection of acute graft-versus-host disease. (22927351)
2012
11
Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. (22127134)
2012
12
Demodicidosis simulating acute graft-versus-host disease after allogeneic stem cell transplantation in one patient with acute lymphoblastic leukemia. (22487272)
2012
13
The effectiveness of tacrolimus and minidose methotrexate in the prevention of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in children: a single-center study in Korea. (22783357)
2012
14
Antithymocyte globulin for acute-graft-versus-host-disease prophylaxis in patients undergoing allogeneic hematopoietic cell transplantation: a systematic review. (22182922)
2012
15
Regulation of acute graft-versus-host disease by microRNA-155. (22408260)
2012
16
Association of HLA-G low expressor genotype with severe acute graft-versus-host disease after sibling bone marrow transplantation. (22566863)
2011
17
Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: a report of two cases. (20514533)
2010
18
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. (19857590)
2010
19
Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft-versus-host disease through up-regulating suppressors of cytokine signalling-3 expression of naive CD4+ T cells. (20132230)
2010
20
Impact of cyclosporine-A concentration on the incidence of severe acute graft-versus-host disease after allogeneic stem cell transplantation. (20053329)
2010
21
Acute graft-versus-host disease: from the bench to the bedside. (19713461)
2009
22
Low serum levels of total rabbit-IgG is associated with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation: results from a prospective study. (19589490)
2009
23
Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease. (19041064)
2008
24
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
25
Acute graft-versus-host disease after pediatric solid organ transplant. (18505140)
2008
26
Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. (18318768)
2008
27
Correlation between serum levels of IL-18 and acute graft versus host disease in patients after allogeneic hematopoietic stem cell transplantation]. (17605864)
2007
28
Atypical acute graft-versus-host disease. (18032957)
2007
29
Facial rash mimicking cutaneous acute graft-versus-host disease after allogeneic stem cell transplantation for osteomyelofibrosis - was Demodex the culprit? (16474408)
2006
30
A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy. (16826221)
2006
31
Expression of CD27 on peripheral CD4+ T-lymphocytes correlates with the development of severe acute graft-versus-host disease after allogeneic bone marrow transplantation. (17118766)
2006
32
Treatment costs and survival in patients with grades III-IV acute graft-versus-host disease after allogenic hematopoietic stem cell transplantation during three decades. (16770251)
2006
33
Acute graft-versus-host disease of the lung with atypical presentation. (16867893)
2006
34
Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: therapeutic challenges. (16879579)
2006
35
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia. (16920564)
2006
36
Protective conditioning for acute graft-versus-host disease. (16192477)
2005
37
Denileukin diftitox for the treatment of steroid-resistant acute graft-versus-host disease. (15744237)
2005
38
Prediction of acute graft-versus-host disease and detection of distinct end-organ targets by enumeration of peripheral blood cytokine spot-forming cells. (16003234)
2005
39
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. (16002422)
2005
40
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
41
Roles of interleukin-10 in acute graft-versus-host disease and graft rejection. (12875717)
2003
42
Role of interleukin-18 in pathogenesis of acute graft-versus-host disease]. (12513747)
2002
43
Serum TNFalpha levels in patients with acute graft-versus-host disease after bone marrow transplantation. (11455978)
2001
44
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. (10779417)
2000
45
Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. (10887333)
2000
46
Elevated interleukin (IL)-18 levels during acute graft-versus-host disease after allogeneic bone marrow transplantation. (10886219)
2000
47
Serum concentration of the soluble interleukin-2 receptor for monitoring acute graft-versus-host disease. (8640164)
1996
48
Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy. (8704686)
1996
49
Antigenaemia during acute graft versus host disease. (7745106)
1995
50
Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor. (8049447)
1994

Variations for Acute Graft Versus Host Disease

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Expression for genes affiliated with Acute Graft Versus Host Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Graft Versus Host Disease

Search GEO for disease gene expression data for Acute Graft Versus Host Disease.

Pathways for genes affiliated with Acute Graft Versus Host Disease

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 55R&D Systems, 58SinoBiological, 54QIAGEN
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Pathways related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.6IL18, IFNG
2
Show member pathways
9.6IL18, IFNG
39.6IL18, IFNG
49.6IFNG, IL18
59.5IL18, TNF
69.5TNF, IL18
7
Show member pathways
9.5TNF, IL18
89.5TNF, IFNG
9
Show member pathways
9.5IFNG, TNF
10
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.5IFNG, TNF
119.5TNF, IFNG
129.5TNF, IFNG
13
Show member pathways
9.5IFNG, TNF
149.5TNF, IFNG
159.5IFNG, TNF
16
Show member pathways
Immune response MIF in innate immunity response61
9.5IFNG, TNF
17
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5IFNG, TNF
18
Show member pathways
9.5TNF, IFNG
19
Show member pathways
thioredoxin pathway39
9.5IFNG, TNF
209.5IFNG, TNF
219.2CD40LG, IFNG
229.1TNF, CD40LG
23
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.1CD40LG, TNF
24
Show member pathways
9.1TNF, IFNG, IL18
25
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1TNF, IFNG, IL18
269.1IL18, IFNG, TNF
27
Show member pathways
IL27-mediated signaling events39
9.1TNF, IFNG, IL18
289.1TNF, IFNG, IL18
299.1IL18, IFNG, TNF
309.1IL18, IFNG, TNF
31
Show member pathways
9.1IL18, IFNG, TNF
329.1TNF, IFNG, IL18
33
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.0TNF, IL18, IL18BP
34
Show member pathways
8.7TNF, IFNG, CD40LG
35
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.7TNF, IFNG, CD40LG
36
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.7CD40LG, IFNG, TNF
37
Show member pathways
8.3TNF, IFNG, IL18, CD40LG
388.3CD40LG, IL18, IFNG, TNF
39
Show member pathways
8.3CD40LG, IL18, IFNG, TNF
40
Show member pathways
8.3TNF, IFNG, IL18, CD40LG

Compounds for genes affiliated with Acute Graft Versus Host Disease

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1interferon gamma469.8IFNG, TNF
2anakinra46 1210.8TNF, IL18
3vesnarinone469.7TNF, IFNG
4taurine chloramine469.7TNF, IFNG
5gold sodium thiomalate469.6IFNG, TNF
6natalizumab46 1210.5TNF, IFNG, IL18
7indoleamine469.5IL18, IFNG, TNF
8imiquimod46 62 30 1212.5IL18, IFNG, TNF
9gm-csf46 3010.5TNF, IFNG, IL18
10polyinosinic-polycytidylic acid469.5IL18, IFNG, TNF
11etanercept46 52 1211.5IL18, IFNG, TNF
12adalimumab46 52 1211.5IFNG, TNF
13poly(i-c)469.5TNF, IFNG, IL18
14il 10469.5IL18, IFNG, TNF
15infliximab46 52 1211.5IL18, IFNG, TNF
16gamma globulin469.5CD40LG, IFNG
17tarc469.5IL18, IFNG, TNF
18ccl346 3010.5TNF, IFNG, IL18
19pentoxifylline46 1210.5TNF, IFNG, IL18
20pdtc469.4IL18, IFNG, TNF
21prednisolone46 30 1211.4TNF, IFNG, IL18
22simvastatin46 52 62 30 25 1214.4TNF, IFNG, IL18
23blys469.3CD40LG, TNF
24tacrolimus46 52 1211.3TNF, IFNG, IL18
25hydroxychloroquine46 1210.2CD40LG, TNF
26tuberculin469.2CD40LG, IL18, IFNG
27ribavirin46 52 1211.2CD40LG, IL18, IFNG
28allergens469.1CD40LG, IL18, IFNG
29okt3469.1TNF, IFNG, CD40LG
30ivig469.1TNF, IFNG, CD40LG
31atorvastatin46 52 30 25 1213.1TNF, IL18, CD40LG
32sb 20358046 6210.0IL18, IFNG, TNF
33herbimycin a46 6210.0TNF, IFNG, CD40LG
34cycloheximide468.8UGT2B17, TNF, IFNG, IL18
35butyrate468.8IL18, IFNG, TNF
36n acetylcysteine468.7TNF, IL18, CD40LG
37il-12468.7CD40LG, IL18, IFNG, TNF
38mycophenolate mofetil46 52 1210.7TNF, IFNG, IL18, CD40LG
39neopterin468.7CD40LG, IL18, IFNG, TNF
40thalidomide46 52 62 1211.7TNF, IFNG, IL18, CD40LG
41ionomycin468.7TNF, IFNG, IL18, CD40LG
42rantes468.7CD40LG, IL18, IFNG, TNF
43indomethacin46 30 62 1211.7TNF, IFNG, IL18, CD40LG
44histamine46 30 2510.7TNF, IFNG, IL18, CD40LG
45cyclosporin a46 30 6210.6TNF, IFNG, IL18, CD40LG
46pge2468.6TNF, IFNG, IL18, CD40LG
47dexamethasone46 52 30 1211.5TNF, IFNG, IL18, CD40LG
48vegf468.5CD40LG, IL18, IFNG, TNF
49endotoxin468.2TNF, IFNG, IL18, IL18BP, CD40LG
50retinoic acid46 259.0UGT2B17, TNF, IFNG, IL18, CD40LG

GO Terms for genes affiliated with Acute Graft Versus Host Disease

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17Gene Ontology
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Cellular components related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6IL18BP, IL18, IFNG, TNF
2external side of plasma membraneGO:0098978.4TNF, IFNG, CD40LG
3extracellular spaceGO:0056157.6CD40LG, IL18BP, IL18, IFNG, TNF

Biological processes related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1T-helper 1 type immune responseGO:0420889.9IL18BP, IL18
2positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IFNG, TNF
4positive regulation of chemokine biosynthetic processGO:0450809.8IFNG, TNF
5positive regulation of NF-kappaB import into nucleusGO:0423469.8TNF, IL18
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, IFNG
7negative regulation of growth of symbiont in hostGO:0441309.8IFNG, TNF
8positive regulation of osteoclast differentiationGO:0456729.8TNF, IFNG
9lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL18, TNF
10protein import into nucleus, translocationGO:0000609.8IFNG, TNF
11cellular response to organic cyclic compoundGO:0714079.7IL18, TNF
12positive regulation of nitric oxide biosynthetic processGO:0454299.7IFNG, TNF
13positive regulation of interferon-gamma productionGO:0327299.6IL18, TNF
14extrinsic apoptotic signaling pathwayGO:0971919.6TNF, IFNG
15humoral immune responseGO:0069599.5IFNG, TNF
16response to virusGO:0096159.5IFNG, TNF
17regulation of immunoglobulin secretionGO:0510239.5TNF, CD40LG
18MAPK cascadeGO:0001659.4TNF, IL18
19positive regulation of interleukin-12 productionGO:0327359.4IFNG, CD40LG
20regulation of insulin secretionGO:0507969.2IFNG, TNF
21inflammatory responseGO:0069548.9TNF, IL18, CD40LG

Molecular functions related to Acute Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1CD40LG, TNF
2cytokine activityGO:0051258.0CD40LG, IL18, IFNG, TNF

Products for genes affiliated with Acute Graft Versus Host Disease

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  • Antibodies
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Sources for Acute Graft Versus Host Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet