MCID: ACT012
MIFTS: 44

Acute Hemorrhagic Conjunctivitis malady

Infectious diseases category
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Summaries for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in human coxsackievirus a24 or has material basis in human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. the infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards: Acute Hemorrhagic Conjunctivitis, also known as epidemic hemorrhagic conjunctivitis, is related to conjunctivitis and dermatitis, and has symptoms including superficial punctate epithelial keratitis, conjunctival congestion and watering of the eye. An important gene associated with Acute Hemorrhagic Conjunctivitis is IL1A (interleukin 1, alpha), and among its related pathways are Hematopoietic cell lineage and Interferon Signaling. The drugs emedastine and emedastine difumarate and the compounds endotoxin and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and endothelial.

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

acute hemorrhagic conjunctivitis 8 10
epidemic hemorrhagic conjunctivitis 8
conjunctivitis, acute hemorrhagic 62
apollo disease 8


External Ids:

Disease Ontology8 DOID:11227
NCIt40 C34505
ICD9CM27 077.4
MeSH35 D003232

Related Diseases for Acute Hemorrhagic Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis11.2
2dermatitis10.1
3keratoconjunctivitis10.1
4dysautonomia10.1
5endotheliitis10.1
6tuberculosis10.1DPEP1
7pyelonephritis10.0DPEP1, CD55
8thymoma10.0CD55, IL1A
9synovitis10.0IL1A, CD55
10graves' disease10.0CD55, IL1A
11systemic scleroderma10.0CD55, IL1A
12myelodysplastic syndromes10.0IL1A, CD55
13sepsis10.0IL1A, CD55
14osteoarthritis10.0CD55, IL1A
15psoriasis10.0CD55, IL1A
16hypersensitivity reaction type ii disease10.0CD55, IL1A
17astrocytoma10.0IL1A, CD55
18ovarian cancer9.9CD55, IL1A
19ulcerative colitis9.9CD55, IL1A, DPEP1
20arthritis9.9CD55, IL1A, DPEP1
21osteosarcoma9.9DPEP1, IL1A, CD55

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to acute hemorrhagic conjunctivitis

Symptoms for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology
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Symptoms:

8 (show all 7)
  • superficial punctate epithelial keratitis
  • conjunctival congestion
  • watering of the eye
  • redness of the eyes
  • photophobia
  • eyelid edema
  • vascular dilation

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Hemorrhagic Conjunctivitis

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Acute Hemorrhagic Conjunctivitis

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Anatomical Context for Acute Hemorrhagic Conjunctivitis

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33MalaCards
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MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

33
Eye, Kidney, Endothelial, Colon

Animal Models for Acute Hemorrhagic Conjunctivitis or affiliated genes

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Publications for Acute Hemorrhagic Conjunctivitis

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52PubMed
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Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007. (20579343)
2010
2
Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. (20724969)
2010
3
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
4
Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by Coxsackie virus A-24 variant. (17457917)
2007
5
Rapid diagnosis of acute hemorrhagic conjunctivitis due to coxsackievirus A24 variant by real-time one-step RT-PCR. (17328967)
2007
6
Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. (15714481)
2005
7
Rapid identification of the coxsackievirus A24 variant by molecular serotyping in an outbreak of acute hemorrhagic conjunctivitis. (15750062)
2005
8
Acute hemorrhagic conjunctivitis caused by coxsackievirus A24 variant, South Korea, 2002. (12967504)
2003
9
Systemic and ocular antibody responses to inactivated acute hemorrhagic conjunctivitis (AHC) virus; enterovirus 70 (EV70). (14566646)
2003
10
Acute hemorrhagic conjunctivitis due to enterovirus 70 in India. (10221880)
1999
11
Acute hemorrhagic conjunctivitis outbreak in Thailand, 1992. (9279984)
1996
12
Analysis of neutralizing antibodies to Enterovirus 70 and Coxsackievirus A24 variant, levels of immunoglobulins and total protein in tears of patients with acute hemorrhagic conjunctivitis. (22823272)
1995
13
A recent epidemic of acute hemorrhagic conjunctivitis. (8394649)
1993
14
The complete nucleotide sequence of a variant of Coxsackievirus A24, an agent causing acute hemorrhagic conjunctivitis. (1317075)
1992
15
Acute hemorrhagic conjunctivitis due to enterovirus 70 in American Samoa: serum-neutralizing antibodies and sex-specific protection. (1337662)
1992
16
Acute hemorrhagic conjunctivitis. (1309404)
1992
17
Evolutionary study on the Coxsackievirus A 24 variant causing acute hemorrhagic conjunctivitis by oligonucleotide mapping analysis of RNA genome. (2171464)
1990
18
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
19
Acute hemorrhagic conjunctivitis caused by coxsackie A24 variant--Puerto Rico. (2828909)
1988
20
Spread of acute hemorrhagic conjunctivitis due to enterovirus-70: effect of air temperature and relative humidity on virus survival on fomites. (2844979)
1988
21
Outbreak of acute hemorrhagic conjunctivitis due to coxsackie A24 variant--Taiwan. (2833097)
1988
22
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
23
Leads from the MMWR. Acute hemorrhagic conjunctivitis caused by coxsackievirus A24--Caribbean. (3586222)
1987
24
Acute hemorrhagic conjunctivitis caused by coxsackievirus A24--Caribbean. (3104763)
1987
25
Virus-specific, early appearing neutralizing activity and interferon in tears of patients with acute hemorrhagic conjunctivitis. (2410189)
1985
26
Re: Acute hemorrhagic conjunctivitis. (2990201)
1985
27
Enterovirus 70 acute hemorrhagic conjunctivitis--sporadic cases. (6381837)
1984
28
Genetic relationship between two enteroviruses causing the acute hemorrhagic conjunctivitis syndrome. (6090340)
1984
29
Acute hemorrhagic conjunctivitis, Key West, Florida. An assessment of risk factors for introduction of illness into households and secondary spread during the 1981 epidemic. (6093501)
1984
30
Epidemic acute hemorrhagic conjunctivitis in Belize. (6652320)
1983
31
Neisseria gonorrhoeae conjunctivitis. An outbreak during an epidemic of acute hemorrhagic conjunctivitis. (6308287)
1983
32
Rapid immunofluorescence diagnosis of acute hemorrhagic conjunctivitis caused by enterovirus 70. (6307917)
1983
33
Acute hemorrhagic conjunctivitis--American Samoa. (6799764)
1982
34
Folk medicines and acute hemorrhagic conjunctivitis. (7137284)
1982
35
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
36
Acute hemorrhagic conjunctivitis--Panama and Belize, 1981. (6793825)
1981
37
Isolation of enterovirus 70 from patients with acute hemorrhagic conjunctivitis in Key West, Florida. (6273726)
1981
38
Seroepidemiologic studies of acute hemorrhagic conjunctivitis virus (enterovirus type 70) in West Africa. III. Studies with animal sera from Ghana and Senegal. (7304572)
1981
39
A polio-like syndrome in adults following acute hemorrhagic conjunctivitis. (6927599)
1981
40
Effect of interferon, elevated temperature, and cell type on replication of acute hemorrhagic conjunctivitis viruses. (200562)
1977
41
Serological studies of radiculomyelitis occurring during the outbreak of acute hemorrhagic conjunctivitis in Senegal in 1970. (184327)
1976
42
Acute hemorrhagic conjunctivitis in Tunisia. Report of viral isolations. (1247410)
1976
43
An epidemic of acute hemorrhagic conjunctivitis in Sendai area, 1973-1974. (189457)
1976
44
Letter: Acute hemorrhagic conjunctivitis associated with adenovirus Type 19. (163967)
1975
45
Neurologic complications with elevated antibody titer after acute hemorrhagic conjunctivitis. (171960)
1975
46
Letter: Adenovirus 19, a cause of epidemic keratoconjunctivitis, not acute hemorrhagic conjunctivitis. (165414)
1975
47
An outbreak of acute hemorrhagic conjunctivitis in Thailand. 2. Epidemiologic investigation. (4832763)
1974
48
Growth characteristics of acute hemorrhagic conjunctivitis (AHC) virus in monkey kidney cells. I. Effect of temperature on viral growth. (4377146)
1974
49
Acute hemorrhagic conjunctivitis. (4612807)
1974
50
An outbreak of acute hemorrhagic conjunctivitis in Thailand. I. Clinical observations. (4783782)
1973

Variations for Acute Hemorrhagic Conjunctivitis

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Expression for genes affiliated with Acute Hemorrhagic Conjunctivitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for genes affiliated with Acute Hemorrhagic Conjunctivitis

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50PathCards, 30KEGG, 55Reactome, 54R&D Systems, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database
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Compounds for genes affiliated with Acute Hemorrhagic Conjunctivitis

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1endotoxin459.6IL1A, DPEP1
2ionomycin459.6IL1A, DPEP1
3n-formylmethionyl-leucylphenylalanine459.6CD55, IL1A
4phosphatidylcholine459.5IL1A, DPEP1
5fmlp459.4IL1A, CD55
6indomethacin45 29 61 1112.4IL1A, DPEP1
7pge2459.4IL1A, DPEP1
8actinomycin d459.2IL1A, CD55
9creatinine459.0CD55, IL1A, DPEP1
10cyclosporin a45 29 6111.0CD55, IL1A
11nitric oxide45 24 1111.0DPEP1, IL1A, CD55

GO Terms for genes affiliated with Acute Hemorrhagic Conjunctivitis

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16Gene Ontology
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Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312259.3CD55, DPEP1
2apical plasma membraneGO:0163249.3CD55, DPEP1
3extracellular spaceGO:0056158.5IL1A, IFNA7, DPEP1
4extracellular regionGO:0055768.2IFNA7, IL1A, CD55

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:0192219.1IL1A, IFNA7
2response to virusGO:0096158.7CD55, IFNA7

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL1A, IFNA7

Products for genes affiliated with Acute Hemorrhagic Conjunctivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Hemorrhagic Conjunctivitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet