MCID: ACT012
MIFTS: 39

Acute Hemorrhagic Conjunctivitis malady

Summaries for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in human coxsackievirus a24 or has material basis in human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. the infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards: Acute Hemorrhagic Conjunctivitis, also known as epidemic hemorrhagic conjunctivitis, is related to acute conjunctivitis and conjunctivitis, and has symptoms including superficial punctate epithelial keratitis, conjunctival congestion and watering of the eye. An important gene associated with Acute Hemorrhagic Conjunctivitis is NR0B1 (nuclear receptor subfamily 0, group B, member 1), and among its related pathways are Hematopoietic cell lineage and Cytokine Network. The drugs emedastine and emedastine difumarate and the compounds n-formylmethionyl-leucylphenylalanine and progesterone have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and endothelial.

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

acute hemorrhagic conjunctivitis 8 10
epidemic hemorrhagic conjunctivitis 8
conjunctivitis, acute hemorrhagic 60
apollo disease 8


External Ids:

Disease Ontology8 DOID:11227
ICD9CM27 077.4
NCIt39 C34505
MeSH34 D003232

Related Diseases for Acute Hemorrhagic Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1acute conjunctivitis11.1
2conjunctivitis11.1
3hemorrhagic disease10.3
4adult syndrome10.1
5dermatitis10.1
6eye disease10.1
7keratoconjunctivitis10.1
8measles10.0CD55
9meningitis10.0CD55
10pyelonephritis10.0CD55, DPEP1
11ulcerative colitis10.0DPEP1, CD55, IL1A
12osteosarcoma10.0IL1A, CD55, DPEP1
13hypersensitivity reaction type ii disease10.0NR0B1, CD55, IL1A
14ovarian cancer10.0IL1A, CD55, NR0B1

Graphical network of diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to acute hemorrhagic conjunctivitis

Clinical Features for Acute Hemorrhagic Conjunctivitis

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8Disease Ontology
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Symptoms:

8 (show all 7)
  • superficial punctate epithelial keratitis
  • conjunctival congestion
  • watering of the eye
  • redness of the eyes
  • photophobia
  • eyelid edema
  • vascular dilation

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Hemorrhagic Conjunctivitis

Drug clinical trials:

Search ClinicalTrials for Acute Hemorrhagic Conjunctivitis

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Search CenterWatch for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acute Hemorrhagic Conjunctivitis

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Anatomical Context for Acute Hemorrhagic Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

32
Eye, Kidney, Endothelial, Colon

Animal Models for Acute Hemorrhagic Conjunctivitis or affiliated genes

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Publications for Acute Hemorrhagic Conjunctivitis

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50PubMed
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Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Molecular identification and phylogenetic study of coxsackievirus A24 variant isolated from an outbreak of acute hemorrhagic conjunctivitis in India in 2010. (23124888)
2013
2
Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. (22336176)
2012
3
An antiviral small-interfering RNA simultaneously effective against the most prevalent enteroviruses causing acute hemorrhagic conjunctivitis. (20739472)
2011
4
Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007. (20579343)
2010
5
Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. (20724969)
2010
6
Understanding of acute hemorrhagic conjunctivitis (AHC) epidemics and outbreaks of Paederus spp keratoconjuctivitis, periorbital oedema ("Nairobi red eyes") and dermatitis. (21516962)
2010
7
Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24: Guangdong, China, 2007. (18712817)
2008
8
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
9
Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by Coxsackie virus A-24 variant. (17457917)
2007
10
Rapid diagnosis of acute hemorrhagic conjunctivitis due to coxsackievirus A24 variant by real-time one-step RT-PCR. (17328967)
2007
11
Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. (15714481)
2005
12
Rapid identification of the coxsackievirus A24 variant by molecular serotyping in an outbreak of acute hemorrhagic conjunctivitis. (15750062)
2005
13
Systemic and ocular antibody responses to inactivated acute hemorrhagic conjunctivitis (AHC) virus; enterovirus 70 (EV70). (14566646)
2003
14
Acute hemorrhagic conjunctivitis due to enterovirus 70 in India. (10221880)
1999
15
From the Centers for Disease Control and Prevention. Acute hemorrhagic conjunctivitis--St Croix, US Virgin Islands, September-October 1998. (9842938)
1998
16
Detection of enterovirus 70 by polymerase chain reaction in acute hemorrhagic conjunctivitis. (8694103)
1996
17
Analysis of neutralizing antibodies to Enterovirus 70 and Coxsackievirus A24 variant, levels of immunoglobulins and total protein in tears of patients with acute hemorrhagic conjunctivitis. (22823272)
1995
18
A recent epidemic of acute hemorrhagic conjunctivitis. (8394649)
1993
19
The complete nucleotide sequence of a variant of Coxsackievirus A24, an agent causing acute hemorrhagic conjunctivitis. (1317075)
1992
20
Acute hemorrhagic conjunctivitis due to enterovirus 70 in American Samoa: serum-neutralizing antibodies and sex-specific protection. (1337662)
1992
21
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
22
Outbreak of acute hemorrhagic conjunctivitis due to coxsackie A24 variant--Taiwan. (2833097)
1988
23
An outbreak of acute hemorrhagic conjunctivitis due to Coxsackie virus type A24 variant in Japan. (2842526)
1988
24
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
25
Acute hemorrhagic conjunctivitis epidemic in Colon, Republic of Panama. (3946379)
1986
26
The etiology of acute hemorrhagic conjunctivitis (AHC) in Beijing. (2829163)
1986
27
Activity of arildone with or without interferon against acute hemorrhagic conjunctivitis viruses in cell culture. (2416272)
1985
28
Enterovirus 70 acute hemorrhagic conjunctivitis--sporadic cases. (6381837)
1984
29
Acute hemorrhagic conjunctivitis, Key West, Florida. An assessment of risk factors for introduction of illness into households and secondary spread during the 1981 epidemic. (6093501)
1984
30
Acute hemorrhagic conjunctivitis in Puerto Rico, 1981-1982. (6089546)
1984
31
Acute hemorrhagic conjunctivitis. (6199813)
1984
32
Epidemic acute hemorrhagic conjunctivitis in Belize. (6652320)
1983
33
Neisseria gonorrhoeae conjunctivitis. An outbreak during an epidemic of acute hemorrhagic conjunctivitis. (6308287)
1983
34
An outbreak of acute hemorrhagic conjunctivitis in central Minnesota. (6624826)
1983
35
Dysautonomia in acute hemorrhagic conjunctivitis. (6674310)
1983
36
Clinical findings and results of treatment in an outbreak of acute hemorrhagic conjunctivitis in southern Florida. (6849368)
1983
37
Folk medicines and acute hemorrhagic conjunctivitis. (7137284)
1982
38
Acute hemorrhagic conjunctivitis in Southeast Asian refugees arriving in the United States--isolation of enterovirus 70. (6282147)
1982
39
Neurologic manifestations of acute hemorrhagic conjunctivitis. (7125986)
1982
40
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
41
Acute hemorrhagic conjunctivitis--Panama and Belize, 1981. (6793825)
1981
42
A polio-like syndrome in adults following acute hemorrhagic conjunctivitis. (6927599)
1981
43
Seroepidemiologic studies of acute hemorrhagic conjunctivitis virus (enterovirus type 70) in West Africa. II. Studies with human sera collected in West African countries other than Ghana. (7304563)
1981
44
Isolation of enterovirus 70 from patient with acute hemorrhagic conjunctivitis-- Key West, Florida. (6270522)
1981
45
Replication of acute hemorrhagic conjunctivitis viruses in conjunctival-corneal cell cultures of mice, rabbits, and monkeys. (6254904)
1980
46
Effect of interferon, elevated temperature, and cell type on replication of acute hemorrhagic conjunctivitis viruses. (200562)
1977
47
Acute hemorrhagic conjunctivitis: a mixed virus outbreak among Vietnamese refugees on Guam. (188334)
1977
48
Letter: Adenovirus 19, a cause of epidemic keratoconjunctivitis, not acute hemorrhagic conjunctivitis. (165414)
1975
49
An outbreak of acute hemorrhagic conjunctivitis in Yugoslavia in 1973. (239379)
1975
50
Editorial: Acute hemorrhagic conjunctivitis. (4369944)
1974

Genetic Variations for Acute Hemorrhagic Conjunctivitis

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Expression for genes affiliated with Acute Hemorrhagic Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for genes affiliated with Acute Hemorrhagic Conjunctivitis

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29KEGG, 51QIAGEN
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Pathways related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1A, CD55
29.4IL1A, IFNA7
3
Hide members
8.9IL1A, CD55, IFNA7

Compounds for genes affiliated with Acute Hemorrhagic Conjunctivitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-formylmethionyl-leucylphenylalanine449.4IL1A, CD55
2progesterone44 59 28 11 2413.2IL1A, CD55, NR0B1
3creatinine448.4IL1A, CD55, DPEP1

GO Terms for genes affiliated with Acute Hemorrhagic Conjunctivitis

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16Gene Ontology
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Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:0312259.1CD55, DPEP1
2apical plasma membraneGO:0163248.3CD55, DPEP1, MTDH

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:0457669.5IL1A, MTDH

Products for genes affiliated with Acute Hemorrhagic Conjunctivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Hemorrhagic Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet