MCID: ACT012
MIFTS: 37

Acute Hemorrhagic Conjunctivitis malady

Categories: Infectious diseases

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

Aliases & Descriptions for Acute Hemorrhagic Conjunctivitis:

Name: Acute Hemorrhagic Conjunctivitis 12 14
Conjunctivitis, Acute Hemorrhagic 42 69
Viral Conjunctivitis 12 69
Epidemic Hemorrhagic Conjunctivitis 12
Apollo Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11227
ICD9CM 35 077.4
MeSH 42 D003232
NCIt 47 C34505
ICD10 33 B30
UMLS 69 C0009765

Summaries for Acute Hemorrhagic Conjunctivitis

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards based summary : Acute Hemorrhagic Conjunctivitis, also known as conjunctivitis, acute hemorrhagic, is related to conjunctivitis and combined oxidative phosphorylation deficiency 8, and has symptoms including vascular dilation, eyelid edema and photophobia. An important gene associated with Acute Hemorrhagic Conjunctivitis is EVC (EvC Ciliary Complex Subunit 1). The drugs Ganciclovir and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and endothelial, and related phenotype is Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers.

Wikipedia : 71 Acute hemorrhagic conjunctivitis (AHC) (also spelled acute haemorrhagic conjunctivitis) is a derivative... more...

Related Diseases for Acute Hemorrhagic Conjunctivitis

Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 conjunctivitis 10.7
2 combined oxidative phosphorylation deficiency 8 9.9 PLD3 PSEN2
3 pseudomembranous conjunctivitis 9.8 PLD3 PSEN2
4 chronic subinvolution of uterus 9.8 PLD3 PSEN2
5 balanoposthitis 9.8 PLD3 PSEN2
6 intravascular angioleiomyoma 9.7 PLD3 PSEN2
7 acute conjunctivitis 9.6
8 dermatitis 9.6
9 keratoconjunctivitis 9.6
10 dysautonomia 9.6
11 endotheliitis 9.6
12 orbital periostitis 9.1 CD55 EVC MATN3 PLD3 PSEN2 SELPLG

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to Acute Hemorrhagic Conjunctivitis

Symptoms & Phenotypes for Acute Hemorrhagic Conjunctivitis

Symptoms:

12
  • vascular dilation
  • eyelid edema
  • photophobia
  • redness of the eyes
  • watering of the eye
  • conjunctival congestion
  • superficial punctate epithelial keratitis

GenomeRNAi Phenotypes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.62 MATN3 SELPLG

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

Drugs for Acute Hemorrhagic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Phase 3 82410-32-0 3454
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
5
Menthol Approved Phase 4 2216-51-5 16666
6 Anti-Infective Agents Phase 4,Phase 3
7 Antiviral Agents Phase 4,Phase 3
8 Ganciclovir triphosphate Phase 4,Phase 3
9 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
10 Antifungal Agents Phase 4
11 Antirheumatic Agents Phase 4,Phase 2,Phase 3
12 Calcineurin Inhibitors Phase 4
13 Carboxymethylcellulose Sodium Phase 4,Phase 2,Phase 3
14 Dermatologic Agents Phase 4
15 Immunosuppressive Agents Phase 4
16 Ophthalmic Solutions Phase 4,Phase 2,Phase 3
17 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
18 Anti-Infective Agents, Local Phase 4,Phase 3
19 Blood Substitutes Phase 4,Phase 3
20 cadexomer iodine Phase 4,Phase 3
21
Iodine Phase 4,Phase 3 7553-56-2 807
22 Micronutrients Phase 4,Phase 3
23 Plasma Substitutes Phase 4,Phase 3
24 Povidone Phase 4,Phase 3
25 Trace Elements Phase 4,Phase 3
26
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
27
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
28
Sulfamethoxazole Approved Phase 3 723-46-6 5329
29
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
31
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
32 Lubricant Eye Drops Phase 3,Phase 2
33 Analgesics Phase 2, Phase 3
34 Analgesics, Non-Narcotic Phase 2, Phase 3
35 Anti-Inflammatory Agents Phase 2, Phase 3
36 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
37 Cathartics Phase 2, Phase 3
38 Cyclooxygenase Inhibitors Phase 2, Phase 3
39 Gastrointestinal Agents Phase 2, Phase 3
40 Ketorolac Tromethamine Phase 2, Phase 3
41 Laxatives Phase 2, Phase 3
42 Peripheral Nervous System Agents Phase 2, Phase 3
43 Tetrahydrozoline Phase 2, Phase 3
44 Antiemetics Phase 3,Phase 2
45 Antineoplastic Agents, Hormonal Phase 3,Phase 2
46 Autonomic Agents Phase 3,Phase 2
47 BB 1101 Phase 3,Phase 2
48 Dexamethasone 21-phosphate Phase 3,Phase 2
49 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
50 glucocorticoids Phase 3,Phase 2

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis Unknown status NCT01533480 Phase 4
2 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4
3 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4
4 Water Uptake for Health in Amhara Pilot Active, not recruiting NCT02373657 Phase 4
5 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3
6 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Acute Viral Conjunctivitis Completed NCT01799863 Phase 2, Phase 3
7 A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3
8 Prophylactic Antibiotics in Measles Completed NCT00168532 Phase 3
9 Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Placebo Recruiting NCT02998554 Phase 3
10 Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo Recruiting NCT02998541 Phase 3
11 FST-100 in the Treatment of Acute Viral Conjunctivitis Completed NCT01461954 Phase 2
12 Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Epidemic Keratoconjunctivitis (EKC) Completed NCT01977443 Phase 2
13 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2
14 FST-100 Ophthalmic Suspension in Acute Adenoviral Conjunctivitis Terminated NCT00941486 Phase 2
15 Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240) Withdrawn NCT03009799 Phase 2
16 Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Completed NCT01349452
17 ADenoVirus Initiative Study in Epidemiology in Italy Completed NCT03055065
18 ADenoVirus Initiative Study in Epidemiology in Spain Completed NCT02254330
19 ADenoVirus Initiative Study in Epidemiology in UK Completed NCT02112773
20 ADenoVirus Initiative Study in Epidemiology in Germany Completed NCT02054273
21 ADenoVirus Initiative Study in Epidemiology in France Completed NCT02054234
22 Evaluation of a Rapid Screening Test for Detection of Adenovirus in Tears Completed NCT00266734
23 A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis Completed NCT00921895
24 Reducing Adenoviral Patient Infected Days Recruiting NCT02472223
25 Etiology Study of Kawasaki Disease Recruiting NCT00154596

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: conjunctivitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Conjunctivitis

Anatomical Context for Acute Hemorrhagic Conjunctivitis

MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

39
Eye, Kidney, Endothelial, Colon

Publications for Acute Hemorrhagic Conjunctivitis

Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50) (show all 115)
id Title Authors Year
1
Acute hemorrhagic conjunctivitis epidemic in SALo Paulo State, Brazil, 2011. ( 27754516 )
2016
2
Acute hemorrhagic conjunctivitis: anti-coxsackievirus A24 variant secretory immunoglobulin A in acute and convalescent tear. ( 26392747 )
2015
3
Virological and epidemiological analysis of coxsackievirus A24 variant epidemic of acute hemorrhagic conjunctivitis in Okinawa, Japan, in 2011. ( 26109843 )
2015
4
Molecular evolution of VP3, VP1, 3C(pro) and 3D(pol) coding regions in coxsackievirus group A type 24 variant isolates from acute hemorrhagic conjunctivitis in 2011 in Okinawa, Japan. ( 24517637 )
2014
5
Genetic characteristics of the coxsackievirus A24 variant causing outbreaks of acute hemorrhagic conjunctivitis in Jiangsu, China, 2010. ( 24475191 )
2014
6
Molecular identification and phylogenetic study of coxsackievirus A24 variant isolated from an outbreak of acute hemorrhagic conjunctivitis in India in 2010. ( 23124888 )
2013
7
A molecular investigative approach to an outbreak of acute hemorrhagic conjunctivitis in Egypt, October 2010. ( 23531270 )
2013
8
Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. ( 22336176 )
2012
9
An antiviral small-interfering RNA simultaneously effective against the most prevalent enteroviruses causing acute hemorrhagic conjunctivitis. ( 20739472 )
2011
10
Molecular characterization and phylogenetic study of coxsackievirus A24v causing outbreaks of acute hemorrhagic conjunctivitis (AHC) in Brazil. ( 21858030 )
2011
11
Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007. ( 20579343 )
2010
12
Understanding of acute hemorrhagic conjunctivitis (AHC) epidemics and outbreaks of Paederus spp keratoconjuctivitis, periorbital oedema ("Nairobi red eyes") and dermatitis. ( 21516962 )
2010
13
Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. ( 20724969 )
2010
14
Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24: Guangdong, China, 2007. ( 18712817 )
2008
15
An outbreak of acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant in Pakistan. ( 18638510 )
2008
16
Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by Coxsackie virus A-24 variant. ( 17457917 )
2007
17
Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant. ( 17294159 )
2007
18
Rapid diagnosis of acute hemorrhagic conjunctivitis due to coxsackievirus A24 variant by real-time one-step RT-PCR. ( 17328967 )
2007
19
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. ( 17680326 )
2007
20
Acute hemorrhagic conjunctivitis epidemic caused by coxsackievirus A24 variants in Korea during 2002-2003. ( 16299722 )
2006
21
Viral investigation of acute hemorrhagic conjunctivitis outbreak (2003) in Nepal using molecular methods. ( 17333732 )
2006
22
Acute hemorrhagic conjunctivitis and coxsackievirus A24v, Rio de Janeiro, Brazil, 2004. ( 16704792 )
2006
23
Rapid identification of the coxsackievirus A24 variant by molecular serotyping in an outbreak of acute hemorrhagic conjunctivitis. ( 15750062 )
2005
24
Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. ( 15714481 )
2005
25
Acute hemorrhagic conjunctivitis outbreak caused by Coxsackievirus A24--Puerto Rico, 2003. ( 15269699 )
2004
26
Towards an in vitro model for acute hemorrhagic conjunctivitis: cytokine-mediated vascular endothelial cell activation triggered by enterovirus type 70 infection. ( 15072749 )
2004
27
Acute hemorrhagic conjunctivitis epidemic--2003 in Nepal. ( 15024766 )
2003
28
Systemic and ocular antibody responses to inactivated acute hemorrhagic conjunctivitis (AHC) virus; enterovirus 70 (EV70). ( 14566646 )
2003
29
Acute hemorrhagic conjunctivitis caused by coxsackievirus A24 variant, South Korea, 2002. ( 12967504 )
2003
30
Acute hemorrhagic conjunctivitis due to enterovirus 70 in India. ( 10221880 )
1999
31
Acute hemorrhagic conjunctivitis--St. Croix, U.S. Virgin Islands, September-October 1998. ( 9810014 )
1998
32
From the Centers for Disease Control and Prevention. Acute hemorrhagic conjunctivitis--St Croix, US Virgin Islands, September-October 1998. ( 9842938 )
1998
33
Corneal superinfection in acute hemorrhagic conjunctivitis. ( 9820942 )
1998
34
Acute hemorrhagic conjunctivitis outbreak in Thailand, 1992. ( 9279984 )
1996
35
Detection of enterovirus 70 by polymerase chain reaction in acute hemorrhagic conjunctivitis. ( 8694103 )
1996
36
Analysis of neutralizing antibodies to Enterovirus 70 and Coxsackievirus A24 variant, levels of immunoglobulins and total protein in tears of patients with acute hemorrhagic conjunctivitis. ( 22823272 )
1995
37
Inhibition of the enteroviruses that cause acute hemorrhagic conjunctivitis (AHC) by benzimidazoles; enviroxime (LY 122772) and enviradone (LY 127123). ( 8540755 )
1995
38
A recent epidemic of acute hemorrhagic conjunctivitis. ( 8394649 )
1993
39
Acute hemorrhagic conjunctivitis due to enterovirus 70 in American Samoa: serum-neutralizing antibodies and sex-specific protection. ( 1337662 )
1992
40
Acute hemorrhagic conjunctivitis. ( 1309404 )
1992
41
The complete nucleotide sequence of a variant of Coxsackievirus A24, an agent causing acute hemorrhagic conjunctivitis. ( 1317075 )
1992
42
Evolutionary study on the Coxsackievirus A 24 variant causing acute hemorrhagic conjunctivitis by oligonucleotide mapping analysis of RNA genome. ( 2171464 )
1990
43
Acute hemorrhagic conjunctivitis--Mexico. ( 2540410 )
1989
44
An epidemic of acute hemorrhagic conjunctivitis in American Samoa caused by coxsackievirus A24 variant. ( 2556026 )
1989
45
Spread of acute hemorrhagic conjunctivitis due to enterovirus-70: effect of air temperature and relative humidity on virus survival on fomites. ( 2844979 )
1988
46
Outbreak of acute hemorrhagic conjunctivitis due to coxsackie A24 variant--Taiwan. ( 2833097 )
1988
47
The first epidemic of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant in Okinawa, Japan, in 1985-1986. ( 2855085 )
1988
48
Acute hemorrhagic conjunctivitis caused by coxsackie A24 variant--Puerto Rico. ( 2828909 )
1988
49
An outbreak of acute hemorrhagic conjunctivitis due to Coxsackie virus type A24 variant in Japan. ( 2842526 )
1988
50
Acute hemorrhagic conjunctivitis caused by coxsackievirus A24--Caribbean. ( 3104763 )
1987

Variations for Acute Hemorrhagic Conjunctivitis

Expression for Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for Acute Hemorrhagic Conjunctivitis

GO Terms for Acute Hemorrhagic Conjunctivitis

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 8.96 EVC MATN3
2 viral entry into host cell GO:0046718 8.62 CD55 SELPLG

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CD55 SELPLG

Sources for Acute Hemorrhagic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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