AHL
MCID: ACT032
MIFTS: 28

Acute Hemorrhagic Leukoencephalitis (AHL) malady

Summaries for Acute Hemorrhagic Leukoencephalitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Acute hemorrhagic leukoencephalitis (ahl) is a very rare form of acute disseminated encephalomyelitis that usually results in death. it is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. it may also cause bleeding in the brain, leading to damage of the white matter. symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. ahl has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. although the exact cause is unclear, ahl usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to ahl. last updated: 8/19/2011

MalaCards: Acute Hemorrhagic Leukoencephalitis, also known as acute haemorrhagic leucoencephalitis of weston hurst, is related to hemorrhage, intracerebral and west syndrome. An important gene associated with Acute Hemorrhagic Leukoencephalitis is CFI (complement factor I). The compounds heparin and glucose have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cerebellum.

Wikipedia:64 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually... more...

Description from OMIM:47 606752

Aliases & Classifications for Acute Hemorrhagic Leukoencephalitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 47OMIM, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

acute hemorrhagic leukoencephalitis 8 43 10
acute haemorrhagic leucoencephalitis of weston hurst 8
acute necrotizing hemorrhagic leukoencephalitis 8
leukoencephalitis, acute hemorrhagic 61
acute hemorrhagic encephalomyelitis 8
weston-hurst syndrome 8
ahle 43
ahl 43


External Ids:

Disease Ontology8 DOID:10992
OMIM47 606752
SNOMED-CT57 72986009
NCIt40 C84535
MeSH35 D004684

Related Diseases for Acute Hemorrhagic Leukoencephalitis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Hemorrhagic Leukoencephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhage, intracerebral10.4
2west syndrome10.2
3acute hemorrhagic encephalitis10.2
4mumps10.2
5brain disease10.2
6tuberculosis10.2
7herpes simplex encephalitis10.2
8brain injury10.2
9nephritis10.0CFI
10asthma10.0CFI
11primary hyperoxaluria10.0CFI, NRP1
12malignant glioma10.0NRP1, CFI
13dementia10.0CFI, NRP1

Graphical network of diseases related to Acute Hemorrhagic Leukoencephalitis:



Diseases related to acute hemorrhagic leukoencephalitis

Clinical Features for Acute Hemorrhagic Leukoencephalitis

Sources:
47OMIM
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Clinical features from OMIM:

606752

Drugs & Therapeutics for Acute Hemorrhagic Leukoencephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Hemorrhagic Leukoencephalitis

Drug clinical trials:

Search ClinicalTrials for Acute Hemorrhagic Leukoencephalitis

Search NIH Clinical Center for Acute Hemorrhagic Leukoencephalitis

Search CenterWatch for Acute Hemorrhagic Leukoencephalitis

Genetic Tests for Acute Hemorrhagic Leukoencephalitis

Anatomical Context for Acute Hemorrhagic Leukoencephalitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Hemorrhagic Leukoencephalitis:

33
Spinal cord, Brain, Cerebellum

Animal Models for Acute Hemorrhagic Leukoencephalitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Acute Hemorrhagic Leukoencephalitis

Sources:
51PubMed
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Articles related to Acute Hemorrhagic Leukoencephalitis:

(show all 45)
idTitleAuthorsYear
1
Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient. (24384347)
2014
2
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. (22926405)
2013
3
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection. (23508437)
2013
4
Value of susceptibility-weighted imaging in acute hemorrhagic leukoencephalitis. (22465779)
2012
5
Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. (21519996)
2011
6
Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation. (21448963)
2011
7
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. (20010289)
2010
8
Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion. (19847676)
2010
9
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
10
Acute hemorrhagic leukoencephalitis with atypical features. (19145402)
2009
11
Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. (19917982)
2009
12
Use of therapeutic plasma exchange in the management of acute hemorrhagic leukoencephalitis: a case report and review of the literature. (17524086)
2007
13
Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. (17608318)
2007
14
The importance of EEG and variability of MRI findings in acute hemorrhagic leukoencephalitis. (17038020)
2006
15
Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. (15917264)
2005
16
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report. (16155148)
2005
17
Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection. (15791481)
2005
18
Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. (16163044)
2005
19
Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report. (15122448)
2004
20
Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. (12601124)
2003
21
Acute hemorrhagic leukoencephalitis in male sibs. (11840490)
2002
22
Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. (12206493)
2002
23
Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis. (12402170)
2002
24
Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review. (11810602)
2002
25
Successful recovery after high-dose intravenous methylprednisolone in acute hemorrhagic leukoencephalitis. (11697528)
2001
26
Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). (11200696)
2000
27
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577083)
1999
28
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577082)
1999
29
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577084)
1999
30
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
31
Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. (9373802)
1997
32
Tubular inclusions in macrophages in the brain of a patient with acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome). (8191625)
1994
33
Acute hemorrhagic leukoencephalitis: a cause of acute brainstem dysfunction. (8052903)
1994
34
Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome. (1468137)
1992
35
Acute hemorrhagic leukoencephalitis. (1844176)
1991
36
Acute hemorrhagic leukoencephalitis. (1746242)
1991
37
Acute hemorrhagic leukoencephalitis. A successful recovery. (1929904)
1991
38
An autopsied case of acute hemorrhagic leukoencephalitis. (3773347)
1986
39
Acute hemorrhagic leukoencephalitis: diagnosis by computed tomography. (6742799)
1984
40
Computed tomography in acute hemorrhagic leukoencephalitis. (6721456)
1984
41
Computerized tomography as a diagnostic aid in acute hemorrhagic leukoencephalitis. (6847149)
1983
42
Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature. (1105376)
1975
43
Acute hemorrhagic leukoencephalitis. Report of 2 cases. (6016398)
1967
44
Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings. (4290137)
1967
45
ACUTE HEMORRHAGIC LEUKOENCEPHALITIS; A CLINICAL AND ELECTRON-MICROSCOPIC REPORT OF 2 PATIENTS TREATED WITH SURGICAL DECOMPRESSION. (14058421)
1963

Genetic Variations for Acute Hemorrhagic Leukoencephalitis

Expression for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Hemorrhagic Leukoencephalitis

Search GEO for disease gene expression data for Acute Hemorrhagic Leukoencephalitis.

Pathways for genes affiliated with Acute Hemorrhagic Leukoencephalitis

Compounds for genes affiliated with Acute Hemorrhagic Leukoencephalitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Acute Hemorrhagic Leukoencephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1heparin45 29 11 2412.1CFI, NRP1
2glucose459.1CFI, NRP1
3cholesterol45 29 11 2412.0CFI, NRP1
4estrogen458.8CFI, NRP1

GO Terms for genes affiliated with Acute Hemorrhagic Leukoencephalitis

Products for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Sources for Acute Hemorrhagic Leukoencephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet