MCID: ACT032
MIFTS: 39

Acute Hemorrhagic Leukoencephalitis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Acute Hemorrhagic Leukoencephalitis

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Aliases & Descriptions for Acute Hemorrhagic Leukoencephalitis:

Name: Acute Hemorrhagic Leukoencephalitis 10 45 12
Leukoencephalitis, Acute Hemorrhagic 65 36
Ahl 10 45
Acute Haemorrhagic Leucoencephalitis of Weston Hurst 10
 
Acute Necrotizing Hemorrhagic Leukoencephalitis 10
Acute Hemorrhagic Encephalomyelitis 10
Weston-Hurst Syndrome 10
Ahle 45


Classifications:



External Ids:

Disease Ontology10 DOID:10992
MeSH36 D004684
SNOMED-CT59 72986009
NCIt42 C84535
ICD9CM29 323.9

Summaries for Acute Hemorrhagic Leukoencephalitis

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NIH Rare Diseases:45 Acute hemorrhagic leukoencephalitis (ahl) is a very rare form of acute disseminated encephalomyelitis that usually results in death. it is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. it may also cause bleeding in the brain, leading to damage of the white matter. symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. ahl has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. although the exact cause is unclear, ahl usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to ahl. last updated: 8/19/2011

MalaCards based summary: Acute Hemorrhagic Leukoencephalitis, also known as leukoencephalitis, acute hemorrhagic, is related to herpes simplex and brain injury. An important gene associated with Acute Hemorrhagic Leukoencephalitis is CFI (Complement Factor I), and among its related pathways are Spinal Cord Injury and Apoptosis Signaling Pathways. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are muscle and digestive/alimentary.

Disease Ontology:10 A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema.

Related Diseases for Acute Hemorrhagic Leukoencephalitis

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Diseases related to Acute Hemorrhagic Leukoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex10.5
2brain injury10.3
3relapsing-remitting multiple sclerosis10.3
4mumps10.3
5encephalitis10.3
6influenza10.3
7myopathy10.3
8tuberculosis10.3
9herpes simplex encephalitis10.3
10epididymal neoplasm10.2AQP1, IL1RN
11chronic venous insufficiency10.2AQP4, MBP
12dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease10.2AQP1, AQP4
13hemangioma thrombocytopenia syndrome10.2FLT1, KDR
14hyper-igd syndrome10.1IL1RN, TNFRSF1A
15treponema infection10.1AQP4, MBP
16amphetamine abuse10.1AQP1, AQP4, MBP
17neutropenia10.1AQP1, AQP4, MBP
18choreatic disease10.1IL1RN, TNFRSF1B
19cerebral atherosclerosis10.1TNFRSF1A, TNFRSF1B
20meckel's diverticulum cancer10.1TNFRSF1A, TNFRSF1B
21spinal cord ependymoma10.1AQP4, CD8A, MBP
22paronychia10.0AQP1, AQP4, TNFRSF1A
23compensatory emphysema10.0CD8A, TNFRSF1B
24rubella10.0CD8A, FASLG
25anthrax disease10.0CD8A, IL1RN, TNFRSF1B
26excessive tearing10.0CD8A, IL1RN, TNFRSF1B
27demyelinating polyneuropathy10.0AQP4, MBP, TNFRSF1A
28gum cancer10.0MBP, TNFRSF1A, TNFRSF1B
29polyclonal hypergammaglobulinemia10.0CD8A, TNFRSF1A, TNFRSF1B
30heart lymphoma10.0KDR, NRP1, VEGFA
31malignant cardiac germ cell tumor9.9FLT1, VEGFA
32carbohydrate metabolic disorder9.9KDR, VEGFA
33hypersensitivity vasculitis9.9CD8A, FASLG, TNFRSF1B
34diverticulitis of colon9.9AQP1, AQP4, VEGFA
35indolent systemic mastocytosis9.9FLT1, KDR, VEGFA
36obesity due to melanocortin 4 receptor deficiency9.9FLT1, VEGFA
37hypospadias - hypertelorism - coloboma and deafness9.9FLT1, KDR, VEGFA
38skin melanoma9.9KDR, VEGFA
39vascular disease9.9FLT1, KDR, VEGFA
40corneal ulcer9.8FLT1, KDR, VEGFA
41anterior cranial fossa meningioma9.8FLT1, KDR, VEGFA
42transvestism9.8FLT1, KDR, VEGFA
43adult pulmonary langerhans cell histiocytosis9.8FLT1, KDR, VEGFA
44microvascular complications of diabetes 59.8FLT1, KDR, VEGFA
45subacute leukemia9.8FLT1, VEGFA
46lipodystrophy due to peptidic growth factors deficiency9.8FLT1, VEGFA
47warty dyskeratoma9.8KDR, VEGFA
48exudative vitreoretinopathy 19.8FLT1, KDR, NRP1, VEGFA
49retinal vascular occlusion9.7FLT1, KDR, OCLN, VEGFA
50macular degeneration, age-related, 19.7CFI, FLT1, KDR, VEGFA

Graphical network of the top 20 diseases related to Acute Hemorrhagic Leukoencephalitis:



Diseases related to acute hemorrhagic leukoencephalitis

Symptoms for Acute Hemorrhagic Leukoencephalitis

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Drugs & Therapeutics for Acute Hemorrhagic Leukoencephalitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acute Hemorrhagic Leukoencephalitis


Cochrane evidence based reviews: Leukoencephalitis, Acute Hemorrhagic

Genetic Tests for Acute Hemorrhagic Leukoencephalitis

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Anatomical Context for Acute Hemorrhagic Leukoencephalitis

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MalaCards organs/tissues related to Acute Hemorrhagic Leukoencephalitis:

33
Brain, Spinal cord, Cerebellum

Animal Models for Acute Hemorrhagic Leukoencephalitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Hemorrhagic Leukoencephalitis:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9FLT1, KDR, OCLN, TNFRSF1A, TNFRSF1B, VEGFA
2MP:00053817.8AQP4, FASLG, OCLN, TNFRSF1A, TNFRSF1B, VEGFA
3MP:00053907.6FASLG, IL1RN, KDR, OCLN, TNFRSF1A, TNFRSF1B
4MP:00053677.5AQP1, AQP4, CFI, FASLG, TNFRSF1A, TNFRSF1B
5MP:00053887.3AQP1, AQP4, FASLG, KDR, TNFRSF1A, TNFRSF1B
6MP:00107717.3CD8A, FASLG, IL1RN, KDR, TNFRSF1A, TNFRSF1B
7MP:00053797.1AQP1, AQP4, FASLG, OCLN, TNFRSF1A, TNFRSF1B
8MP:00053786.8AQP1, AQP4, FLT1, IL1RN, KDR, NRP1
9MP:00053866.7AQP1, AQP4, FLT1, KDR, MBP, OCLN
10MP:00053896.5AQP1, FASLG, FLT1, IL1RN, MBP, OCLN
11MP:00053846.5FASLG, FLT1, IL1RN, KDR, MBP, NRP1
12MP:00053856.3AQP1, AQP4, FASLG, FLT1, IL1RN, KDR
13MP:00053916.0AQP1, AQP4, FASLG, FLT1, KDR, MBP
14MP:00053975.6AQP1, CD8A, FASLG, FLT1, IL1RN, KDR
15MP:00107685.3AQP1, AQP4, CD8A, FASLG, FLT1, IL1RN
16MP:00053875.3AQP4, CD8A, FASLG, FLT1, IL1RN, KDR
17MP:00036315.2AQP1, AQP4, CD8A, FASLG, FLT1, KDR
18MP:00053765.2AQP1, AQP4, CFI, FASLG, FLT1, IL1RN

Publications for Acute Hemorrhagic Leukoencephalitis

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Articles related to Acute Hemorrhagic Leukoencephalitis:

(show all 46)
idTitleAuthorsYear
1
Acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with relapse-remitting multiple sclerosis. (26376717)
2015
2
Acute hemorrhagic leukoencephalitis associated with autoimmune myopathy. (25422709)
2014
3
Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient. (24384347)
2014
4
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. (22926405)
2013
5
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection. (23508437)
2013
6
Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. (21519996)
2011
7
Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation. (21448963)
2011
8
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. (20010289)
2010
9
Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion. (19847676)
2010
10
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
11
Acute hemorrhagic leukoencephalitis with atypical features. (19145402)
2009
12
Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. (19917982)
2009
13
Use of therapeutic plasma exchange in the management of acute hemorrhagic leukoencephalitis: a case report and review of the literature. (17524086)
2007
14
Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. (17608318)
2007
15
The importance of EEG and variability of MRI findings in acute hemorrhagic leukoencephalitis. (17038020)
2006
16
Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. (15917264)
2005
17
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report. (16155148)
2005
18
Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection. (15791481)
2005
19
Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. (16163044)
2005
20
Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report. (15122448)
2004
21
Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. (12601124)
2003
22
Acute hemorrhagic leukoencephalitis in male sibs. (11840490)
2002
23
Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. (12206493)
2002
24
Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis. (12402170)
2002
25
Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review. (11810602)
2002
26
Successful recovery after high-dose intravenous methylprednisolone in acute hemorrhagic leukoencephalitis. (11697528)
2001
27
Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). (11200696)
2000
28
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577083)
1999
29
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577082)
1999
30
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577084)
1999
31
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
32
Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. (9373802)
1997
33
Tubular inclusions in macrophages in the brain of a patient with acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome). (8191625)
1994
34
Acute hemorrhagic leukoencephalitis: a cause of acute brainstem dysfunction. (8052903)
1994
35
Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome. (1468137)
1992
36
Acute hemorrhagic leukoencephalitis. (1844176)
1991
37
Acute hemorrhagic leukoencephalitis. (1746242)
1991
38
Acute hemorrhagic leukoencephalitis. A successful recovery. (1929904)
1991
39
An autopsied case of acute hemorrhagic leukoencephalitis. (3773347)
1986
40
Acute hemorrhagic leukoencephalitis: diagnosis by computed tomography. (6742799)
1984
41
Computed tomography in acute hemorrhagic leukoencephalitis. (6721456)
1984
42
Computerized tomography as a diagnostic aid in acute hemorrhagic leukoencephalitis. (6847149)
1983
43
Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature. (1105376)
1975
44
Acute hemorrhagic leukoencephalitis. Report of 2 cases. (6016398)
1967
45
Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings. (4290137)
1967
46
ACUTE HEMORRHAGIC LEUKOENCEPHALITIS; A CLINICAL AND ELECTRON-MICROSCOPIC REPORT OF 2 PATIENTS TREATED WITH SURGICAL DECOMPRESSION. (14058421)
1963

Variations for Acute Hemorrhagic Leukoencephalitis

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Expression for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Search GEO for disease gene expression data for Acute Hemorrhagic Leukoencephalitis.

Pathways for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Pathways related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AQP1, AQP4, MBP
2
Show member pathways
8.9FASLG, TNFRSF1A, TNFRSF1B
3
Show member pathways
8.9FASLG, TNFRSF1A, TNFRSF1B
48.8FLT1, KDR, VEGFA
5
Show member pathways
8.8FLT1, KDR, VEGFA
68.8FLT1, KDR, VEGFA
78.8FLT1, KDR, VEGFA
8
Angiogenesis (WikiPathways)
Show member pathways
8.8FLT1, KDR, VEGFA
9
Show member pathways
8.8FLT1, KDR, VEGFA
10
Show member pathways
8.6FASLG, RANBP2, TNFRSF1A, TNFRSF1B
11
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
12
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
13
VEGF Pathway (Qiagen)
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
148.6FLT1, KDR, RANBP2, VEGFA
158.2FASLG, FLT1, KDR, VEGFA
168.2CD8A, FASLG, IL1RN, TNFRSF1A, TNFRSF1B
17
Show member pathways
7.8FASLG, FLT1, KDR, NRP1, TNFRSF1A, TNFRSF1B
18
Show member pathways
7.7AQP1, AQP4, FLT1, KDR, TNFRSF1A, VEGFA

GO Terms for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Cellular components related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sorting endosomeGO:009744310.7KDR, NRP1
2receptor complexGO:00432359.7FLT1, NRP1, TNFRSF1A
3external side of plasma membraneGO:00098979.4AQP4, CD8A, FASLG, KDR
4membrane raftGO:00451218.5FASLG, KDR, TNFRSF1A, TNFRSF1B
5integral component of plasma membraneGO:00058877.4AQP1, AQP4, CD8A, FASLG, FLT1, KDR
6extracellular spaceGO:00056157.2CFI, FASLG, FLT1, IL1RN, NRP1, TNFRSF1A
7extracellular regionGO:00055766.5CD8A, CFI, FASLG, IL1RN, KDR, TNFRSF1A
8membraneGO:00160206.1AQP1, AQP4, CFI, FASLG, FLT1, KDR
9plasma membraneGO:00058865.8AQP1, AQP4, CD8A, FASLG, FLT1, IL1RN

Biological processes related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1cellular water homeostasisGO:000999210.4AQP1, AQP4
2glycerol transportGO:001579310.4AQP1, AQP4
3multicellular organismal water homeostasisGO:005089110.4AQP1, AQP4
4VEGF-activated neuropilin signaling pathwayGO:003819010.1NRP1, VEGFA
5regulation of retinal ganglion cell axon guidanceGO:009025910.1NRP1, VEGFA
6positive regulation of retinal ganglion cell axon guidanceGO:190233610.1NRP1, VEGFA
7commissural neuron axon guidanceGO:007167910.1NRP1, VEGFA
8endothelial cell chemotaxisGO:003576710.1NRP1, VEGFA
9coronary artery morphogenesisGO:006098210.0NRP1, VEGFA
10regulation of hematopoietic progenitor cell differentiationGO:190153210.0KDR, VEGFA
11positive regulation of positive chemotaxisGO:005092710.0KDR, VEGFA
12surfactant homeostasisGO:004312910.0KDR, VEGFA
13positive regulation of focal adhesion assemblyGO:005189410.0KDR, VEGFA
14regulation of endothelial cell differentiationGO:004560110.0KDR, VEGFA
15artery morphogenesisGO:00488449.9NRP1, VEGFA
16cell migration involved in sprouting angiogenesisGO:00020429.7KDR, NRP1, VEGFA
17positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.7FLT1, VEGFA
18positive regulation of endothelial cell migrationGO:00105959.7KDR, NRP1, VEGFA
19positive regulation of MAPK cascadeGO:00434109.7FLT1, KDR, TNFRSF1B
20positive regulation of axon extension involved in axon guidanceGO:00488429.6NRP1, VEGFA
21transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.5CD8A, FLT1, KDR
22positive regulation of endothelial cell proliferationGO:00019389.4KDR, NRP1, VEGFA
23vascular endothelial growth factor signaling pathwayGO:00380849.3FLT1, KDR, NRP1, VEGFA
24cellular response to vascular endothelial growth factor stimulusGO:00359249.3FLT1, KDR, NRP1, VEGFA
25negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.0AQP1, FASLG, VEGFA
26angiogenesisGO:00015258.9FLT1, KDR, NRP1, VEGFA
27response to lipopolysaccharideGO:00324968.9FASLG, IL1RN, TNFRSF1A, TNFRSF1B
28cell surface receptor signaling pathwayGO:00071668.8CD8A, FASLG, TNFRSF1A, TNFRSF1B
29positive regulation of angiogenesisGO:00457668.8AQP1, FLT1, KDR, VEGFA
30cell migrationGO:00164778.6FLT1, KDR, NRP1, VEGFA
31vascular endothelial growth factor receptor signaling pathwayGO:00480108.3FLT1, KDR, NRP1, VEGFA
32immune responseGO:00069558.1CD8A, FASLG, IL1RN, MBP, TNFRSF1A, TNFRSF1B

Molecular functions related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:003808510.3KDR, NRP1
2water transmembrane transporter activityGO:00053729.8AQP1, AQP4
3vascular endothelial growth factor-activated receptor activityGO:00050219.8FLT1, KDR, NRP1
4tumor necrosis factor-activated receptor activityGO:00050319.8TNFRSF1A, TNFRSF1B
5water channel activityGO:00152509.7AQP1, AQP4
6glycerol channel activityGO:00152549.5AQP1, AQP4
7growth factor bindingGO:00198389.4FLT1, KDR, NRP1

Sources for Acute Hemorrhagic Leukoencephalitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet