AHL
MCID: ACT032
MIFTS: 36

Acute Hemorrhagic Leukoencephalitis (AHL) malady

Rare diseases, Neuronal diseases categories
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Summaries for Acute Hemorrhagic Leukoencephalitis

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NIH Rare Diseases:42 Acute hemorrhagic leukoencephalitis (ahl) is a very rare form of acute disseminated encephalomyelitis that usually results in death. it is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. it may also cause bleeding in the brain, leading to damage of the white matter. symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. ahl has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. although the exact cause is unclear, ahl usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to ahl. last updated: 8/19/2011

MalaCards based summary: Acute Hemorrhagic Leukoencephalitis, also known as AHL, is related to herpes simplex and brain injury. An important gene associated with Acute Hemorrhagic Leukoencephalitis is CFI (complement factor I). The compounds heparin and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum.

Disease Ontology:8 A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and characterized by necrotizing vasculitis of venules and hemorrhage, and edema.

Wikipedia:65 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually... more...

Description from OMIM:46 606752

Aliases & Classifications for Acute Hemorrhagic Leukoencephalitis

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Acute Hemorrhagic Leukoencephalitis, Aliases & Descriptions:

Name: Acute Hemorrhagic Leukoencephalitis 8 42 10
Ahl 8 42 62
Acute Haemorrhagic Leucoencephalitis of Weston Hurst 8 62
Acute Necrotizing Hemorrhagic Leukoencephalitis 8
 
Leukoencephalitis, Acute Hemorrhagic 62
Acute Hemorrhagic Encephalomyelitis 8
Weston-Hurst Syndrome 8
Ahle 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:10992
NCIt39 C84535
OMIM46 606752
SNOMED-CT57 72986009
ICD9CM27 323.9
MeSH34 D004684

Related Diseases for Acute Hemorrhagic Leukoencephalitis

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Diseases related to Acute Hemorrhagic Leukoencephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex10.5
2brain injury10.3
3mumps10.3
4encephalitis10.3
5influenza10.3
6tuberculosis10.3
7herpes simplex encephalitis10.3
8dementia10.0NRP1, CFI
9myeloid leukemia10.0NRP1, CFI
10primary hyperoxaluria9.9CFI, NRP1
11malignant glioma9.9NRP1, CFI
12ovarian cancer9.9NRP1, CFI
13rheumatoid arthritis9.9CFI, NRP1
14melanoma9.9CFI, NRP1
15colonic benign neoplasm9.8NRP1, CFI
16alzheimer's disease9.8NRP1, CFI

Graphical network of diseases related to Acute Hemorrhagic Leukoencephalitis:



Diseases related to acute hemorrhagic leukoencephalitis

Symptoms for Acute Hemorrhagic Leukoencephalitis

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Clinical features from OMIM:

606752

Drugs & Therapeutics for Acute Hemorrhagic Leukoencephalitis

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Drug clinical trials:

Search ClinicalTrials for Acute Hemorrhagic Leukoencephalitis

Search NIH Clinical Center for Acute Hemorrhagic Leukoencephalitis

Genetic Tests for Acute Hemorrhagic Leukoencephalitis

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Anatomical Context for Acute Hemorrhagic Leukoencephalitis

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MalaCards organs/tissues related to Acute Hemorrhagic Leukoencephalitis:

32
Brain, Spinal cord, Cerebellum

Animal Models for Acute Hemorrhagic Leukoencephalitis or affiliated genes

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Publications for Acute Hemorrhagic Leukoencephalitis

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Articles related to Acute Hemorrhagic Leukoencephalitis:

(show all 45)
idTitleAuthorsYear
1
Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient. (24384347)
2014
2
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. (22926405)
2013
3
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection. (23508437)
2013
4
Value of susceptibility-weighted imaging in acute hemorrhagic leukoencephalitis. (22465779)
2012
5
Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. (21519996)
2011
6
Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation. (21448963)
2011
7
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. (20010289)
2010
8
Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion. (19847676)
2010
9
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
10
Acute hemorrhagic leukoencephalitis with atypical features. (19145402)
2009
11
Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. (19917982)
2009
12
Use of therapeutic plasma exchange in the management of acute hemorrhagic leukoencephalitis: a case report and review of the literature. (17524086)
2007
13
Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. (17608318)
2007
14
The importance of EEG and variability of MRI findings in acute hemorrhagic leukoencephalitis. (17038020)
2006
15
Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. (15917264)
2005
16
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report. (16155148)
2005
17
Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection. (15791481)
2005
18
Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. (16163044)
2005
19
Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report. (15122448)
2004
20
Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. (12601124)
2003
21
Acute hemorrhagic leukoencephalitis in male sibs. (11840490)
2002
22
Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. (12206493)
2002
23
Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis. (12402170)
2002
24
Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review. (11810602)
2002
25
Successful recovery after high-dose intravenous methylprednisolone in acute hemorrhagic leukoencephalitis. (11697528)
2001
26
Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). (11200696)
2000
27
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577083)
1999
28
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577082)
1999
29
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577084)
1999
30
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
31
Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. (9373802)
1997
32
Tubular inclusions in macrophages in the brain of a patient with acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome). (8191625)
1994
33
Acute hemorrhagic leukoencephalitis: a cause of acute brainstem dysfunction. (8052903)
1994
34
Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome. (1468137)
1992
35
Acute hemorrhagic leukoencephalitis. (1844176)
1991
36
Acute hemorrhagic leukoencephalitis. (1746242)
1991
37
Acute hemorrhagic leukoencephalitis. A successful recovery. (1929904)
1991
38
An autopsied case of acute hemorrhagic leukoencephalitis. (3773347)
1986
39
Acute hemorrhagic leukoencephalitis: diagnosis by computed tomography. (6742799)
1984
40
Computed tomography in acute hemorrhagic leukoencephalitis. (6721456)
1984
41
Computerized tomography as a diagnostic aid in acute hemorrhagic leukoencephalitis. (6847149)
1983
42
Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature. (1105376)
1975
43
Acute hemorrhagic leukoencephalitis. Report of 2 cases. (6016398)
1967
44
Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings. (4290137)
1967
45
ACUTE HEMORRHAGIC LEUKOENCEPHALITIS; A CLINICAL AND ELECTRON-MICROSCOPIC REPORT OF 2 PATIENTS TREATED WITH SURGICAL DECOMPRESSION. (14058421)
1963

Variations for Acute Hemorrhagic Leukoencephalitis

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Expression for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Expression patterns in normal tissues for genes affiliated with Acute Hemorrhagic Leukoencephalitis

Search GEO for disease gene expression data for Acute Hemorrhagic Leukoencephalitis.

Pathways for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Compounds for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Acute Hemorrhagic Leukoencephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1heparin44 28 24 1112.2NRP1, CFI
2cholesterol44 28 24 1112.2NRP1, CFI
3estrogen449.1NRP1, CFI
4serine449.1NRP1, CFI
5glucose449.0CFI, NRP1
6lipid448.8NRP1, CFI

GO Terms for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Cellular components related to Acute Hemorrhagic Leukoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1NRP1, CFI

Molecular functions related to Acute Hemorrhagic Leukoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:0468729.1NRP1, CFI

Products for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Acute Hemorrhagic Leukoencephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet