MCID: ACT032
MIFTS: 42

Acute Hemorrhagic Leukoencephalitis malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Acute Hemorrhagic Leukoencephalitis

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Aliases & Descriptions for Acute Hemorrhagic Leukoencephalitis:

Name: Acute Hemorrhagic Leukoencephalitis 11 46 13
Leukoencephalitis, Acute Hemorrhagic 37 66
Ahl 11 46
Acute Haemorrhagic Leucoencephalitis of Weston Hurst 11
 
Acute Necrotizing Hemorrhagic Leukoencephalitis 11
Acute Hemorrhagic Encephalomyelitis 11
Weston-Hurst Syndrome 11
Ahle 46

Classifications:



External Ids:

Disease Ontology11 DOID:10992
MeSH37 D004684
SNOMED-CT60 72986009
NCIt43 C84535

Summaries for Acute Hemorrhagic Leukoencephalitis

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NIH Rare Diseases:46 Acute hemorrhagic leukoencephalitis (ahl) is a very rare form of acute disseminated encephalomyelitis that usually results in death. it is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. it may also cause bleeding in the brain, leading to damage of the white matter. symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. ahl has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. although the exact cause is unclear, ahl usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to ahl. last updated: 8/19/2011

MalaCards based summary: Acute Hemorrhagic Leukoencephalitis, also known as leukoencephalitis, acute hemorrhagic, is related to prostate leiomyosarcoma and subpulmonary stenosis. An important gene associated with Acute Hemorrhagic Leukoencephalitis is CFI (Complement Factor I), and among its related pathways are Spinal Cord Injury and Apoptosis - multiple species. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are muscle and digestive/alimentary.

Disease Ontology:11 A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema.

Related Diseases for Acute Hemorrhagic Leukoencephalitis

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Diseases related to Acute Hemorrhagic Leukoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1prostate leiomyosarcoma10.6AQP1, IL1RN
2subpulmonary stenosis10.5AQP1, AQP4
3dystrophinopathies10.5AQP1, AQP4
4cogan-reese syndrome10.5AQP4, MBP
5porokeratosis 3, disseminated superficial actinic10.4IL1RN, TNFRSF1A
6ovarian papillary cystadenoma10.4AQP4, MBP
7cerebral hemorrhage10.3IL1RN, TNFRSF1B
8hemangioma of spleen10.3IL1RN, TNFRSF1B
9hepatic osteogenic sarcoma10.3AQP1, AQP4, MBP
10psoriasis10.3CD8A, TNFRSF1B
11newborn respiratory distress syndrome10.3AQP1, AQP4, MBP
12cerebral atherosclerosis10.2TNFRSF1A, TNFRSF1B
13tetanus10.2CD8A, TNFRSF1B
14neurilemmoma10.2AQP4, CD8A, MBP
15herpes simplex10.2
1646 xy gonadal dysgenesis10.1AQP1, AQP4, TNFRSF1A
17silicosiderosis10.1KDR, VEGFA
18angiomyolipoma10.1AQP4, CD8A, MBP
19vaginal squamous tumor10.1CD8A, IL1RN, TNFRSF1B
20scleroperikeratitis10.1IL1RN, TNFRSF1B
21relapsing-remitting multiple sclerosis10.1
22early congenital syphilis10.1CD8A, IL1RN, TNFRSF1B
23lacrimal system cancer10.1CD8A, IL1RN, TNFRSF1B
24malignant gastric germ cell tumor10.1KDR, VEGFA
25xanthomatosis10.0CD8A, IL1RN, TNFRSF1B
26arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay10.0KDR, VEGFA
27perinatal jaundice due to hepatocellular damage10.0TNFRSF1A, TNFRSF1B
28epidermolysis bullosa10.0KDR, VEGFA
29iliac vein thrombophlebitis10.0KDR, VEGFA
30psoriasis susceptibility 110.0IL1RN, TNFRSF1A, TNFRSF1B
31achilles bursitis10.0MBP, TNFRSF1A, TNFRSF1B
32gastric small cell carcinoma10.0KDR, NRP1, VEGFA
33kidney rhabdoid cancer10.0CD8A, TNFRSF1A, TNFRSF1B
34acute bilateral depigmentation of the iris9.9KDR, VEGFA
35hyperinsulinism9.9CFI, KDR, VEGFA
36brain injury9.9
37mumps9.9
38tuberculosis9.9
39myopathy9.9
40influenza9.9
41encephalitis9.9
42herpes simplex encephalitis9.9
43goodpasture syndrome9.9CD8A, IL1RN, TNFRSF1B
44spinal cord astrocytoma9.9FLT1, VEGFA
45acute dacryocystitis9.9KDR, VEGFA
46spinal muscular atrophy-dandy-walker malformation-cataracts syndrome9.8FLT1, VEGFA
47atrophic rhinitis9.8AQP1, AQP4, VEGFA
48calcaneonavicular coalition9.8KDR, VEGFA
49myelitis9.7AQP4, CD8A, MBP, TNFRSF1A
50bladder urachal carcinoma9.7FLT1, KDR, VEGFA

Graphical network of the top 20 diseases related to Acute Hemorrhagic Leukoencephalitis:



Diseases related to acute hemorrhagic leukoencephalitis

Symptoms for Acute Hemorrhagic Leukoencephalitis

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Drugs & Therapeutics for Acute Hemorrhagic Leukoencephalitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acute Hemorrhagic Leukoencephalitis


Cochrane evidence based reviews: leukoencephalitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Leukoencephalitis

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Anatomical Context for Acute Hemorrhagic Leukoencephalitis

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MalaCards organs/tissues related to Acute Hemorrhagic Leukoencephalitis:

34
Brain, Spinal cord, Cerebellum

Animal Models for Acute Hemorrhagic Leukoencephalitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Hemorrhagic Leukoencephalitis:

39 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7FLT1, KDR, NRP1, OCLN, TNFRSF1A, TNFRSF1B
2MP:00053817.7AQP4, FASLG, OCLN, TNFRSF1A, TNFRSF1B, VEGFA
3MP:00107717.6CD8A, FASLG, IL1RN, KDR, TNFRSF1A, TNFRSF1B
4MP:00053887.5AQP1, AQP4, FASLG, KDR, TNFRSF1A, TNFRSF1B
5MP:00053897.2AQP1, FASLG, FLT1, IL1RN, MBP, OCLN
6MP:00053677.2AQP1, AQP4, CFI, FASLG, TNFRSF1A, TNFRSF1B
7MP:00053907.1FASLG, IL1RN, KDR, OCLN, TNFRSF1A, TNFRSF1B
8MP:00053796.8AQP1, AQP4, CD8A, FASLG, OCLN, TNFRSF1A
9MP:00053846.7FASLG, FLT1, IL1RN, KDR, MBP, NRP1
10MP:00053866.4AQP1, AQP4, FLT1, KDR, MBP, OCLN
11MP:00053786.3AQP1, AQP4, FLT1, IL1RN, KDR, NRP1
12MP:00053856.2AQP1, AQP4, FASLG, FLT1, IL1RN, KDR
13MP:00053916.1AQP1, AQP4, FASLG, FLT1, KDR, MBP
14MP:00053875.7AQP4, CD8A, FASLG, FLT1, IL1RN, KDR
15MP:00107685.5AQP1, AQP4, CD8A, FASLG, FLT1, IL1RN
16MP:00036315.5AQP1, AQP4, CD8A, FASLG, FLT1, KDR
17MP:00053975.4AQP1, AQP4, CD8A, CFI, FASLG, FLT1
18MP:00053765.1AQP1, AQP4, CFI, FASLG, FLT1, IL1RN

Publications for Acute Hemorrhagic Leukoencephalitis

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Articles related to Acute Hemorrhagic Leukoencephalitis:

(show all 49)
idTitleAuthorsYear
1
Commentary: Acute Hemorrhagic Leukoencephalitis (Weston-Hurst Syndrome) in a Patient with Relapse-Remitting Multiple Sclerosis. (27252706)
2016
2
Acute Hemorrhagic Leukoencephalitis in Children: A Case Report. (27217610)
2016
3
Acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with relapse-remitting multiple sclerosis. (26376717)
2015
4
Acute hemorrhagic leukoencephalitis associated with autoimmune myopathy. (25422709)
2014
5
Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient. (24384347)
2014
6
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. (22926405)
2013
7
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection. (23508437)
2013
8
Value of susceptibility-weighted imaging in acute hemorrhagic leukoencephalitis. (22465779)
2012
9
Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. (21519996)
2011
10
Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation. (21448963)
2011
11
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. (20010289)
2010
12
Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion. (19847676)
2010
13
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
14
Acute hemorrhagic leukoencephalitis with atypical features. (19145402)
2009
15
Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. (19917982)
2009
16
Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. (17608318)
2007
17
Use of therapeutic plasma exchange in the management of acute hemorrhagic leukoencephalitis: a case report and review of the literature. (17524086)
2007
18
The importance of EEG and variability of MRI findings in acute hemorrhagic leukoencephalitis. (17038020)
2006
19
Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. (15917264)
2005
20
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report. (16155148)
2005
21
Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection. (15791481)
2005
22
Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. (16163044)
2005
23
Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report. (15122448)
2004
24
Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. (12601124)
2003
25
Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis. (12402170)
2002
26
Acute hemorrhagic leukoencephalitis in male sibs. (11840490)
2002
27
Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. (12206493)
2002
28
Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review. (11810602)
2002
29
Successful recovery after high-dose intravenous methylprednisolone in acute hemorrhagic leukoencephalitis. (11697528)
2001
30
Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). (11200696)
2000
31
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577083)
1999
32
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577082)
1999
33
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577084)
1999
34
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
35
Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. (9373802)
1997
36
Tubular inclusions in macrophages in the brain of a patient with acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome). (8191625)
1994
37
Acute hemorrhagic leukoencephalitis: a cause of acute brainstem dysfunction. (8052903)
1994
38
Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome. (1468137)
1992
39
Acute hemorrhagic leukoencephalitis. (1844176)
1991
40
Acute hemorrhagic leukoencephalitis. (1746242)
1991
41
Acute hemorrhagic leukoencephalitis. A successful recovery. (1929904)
1991
42
An autopsied case of acute hemorrhagic leukoencephalitis. (3773347)
1986
43
Acute hemorrhagic leukoencephalitis: diagnosis by computed tomography. (6742799)
1984
44
Computed tomography in acute hemorrhagic leukoencephalitis. (6721456)
1984
45
Computerized tomography as a diagnostic aid in acute hemorrhagic leukoencephalitis. (6847149)
1983
46
Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature. (1105376)
1975
47
Acute hemorrhagic leukoencephalitis. Report of 2 cases. (6016398)
1967
48
Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings. (4290137)
1967
49
ACUTE HEMORRHAGIC LEUKOENCEPHALITIS; A CLINICAL AND ELECTRON-MICROSCOPIC REPORT OF 2 PATIENTS TREATED WITH SURGICAL DECOMPRESSION. (14058421)
1963

Variations for Acute Hemorrhagic Leukoencephalitis

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Expression for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Search GEO for disease gene expression data for Acute Hemorrhagic Leukoencephalitis.

Pathways for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Pathways related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.5AQP1, AQP4, MBP
2
Show member pathways
8.9FASLG, TNFRSF1A, TNFRSF1B
3
Show member pathways
8.9FASLG, TNFRSF1A, TNFRSF1B
48.8FLT1, KDR, VEGFA
5
Show member pathways
8.8FLT1, KDR, VEGFA
6
Show member pathways
8.8FLT1, KDR, VEGFA
7
Show member pathways
8.8FLT1, KDR, VEGFA
88.8FLT1, KDR, VEGFA
98.8FLT1, KDR, VEGFA
10
Show member pathways
8.8FLT1, KDR, VEGFA
11
Show member pathways
8.7FLT1, KDR, TNFRSF1A, TNFRSF1B
12
Show member pathways
8.7FLT1, KDR, TNFRSF1A, TNFRSF1B
13
Show member pathways
8.6FASLG, RANBP2, TNFRSF1A, TNFRSF1B
14
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
15
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
16
Show member pathways
8.6FLT1, KDR, NRP1, VEGFA
178.6FLT1, KDR, RANBP2, VEGFA
188.2FASLG, FLT1, KDR, VEGFA
198.2CD8A, FASLG, IL1RN, TNFRSF1A, TNFRSF1B
20
Show member pathways
7.8FASLG, FLT1, KDR, NRP1, TNFRSF1A, TNFRSF1B
21
Show member pathways
7.7AQP1, AQP4, FLT1, KDR, TNFRSF1A, VEGFA
22
Show member pathways
7.0FASLG, FLT1, KDR, NRP1, TNFRSF1A, TNFRSF1B

GO Terms for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Cellular components related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sorting endosomeGO:009744310.6KDR, NRP1
2receptor complexGO:00432359.8FLT1, NRP1, TNFRSF1A
3membrane raftGO:00451219.0FASLG, KDR, TNFRSF1A, TNFRSF1B
4cell surfaceGO:00099868.2CD8A, FASLG, NRP1, TNFRSF1A, VEGFA
5extracellular spaceGO:00056157.5CFI, FASLG, FLT1, IL1RN, NRP1, TNFRSF1A
6extracellular regionGO:00055767.1CD8A, CFI, FASLG, IL1RN, KDR, TNFRSF1A
7integral component of plasma membraneGO:00058877.0AQP1, AQP4, CD8A, FASLG, FLT1, KDR
8plasma membraneGO:00058865.5AQP1, AQP4, CD8A, FASLG, FLT1, IL1RN

Biological processes related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:001579310.4AQP1, AQP4
2cellular water homeostasisGO:000999210.4AQP1, AQP4
3water transportGO:000683310.4AQP1, AQP4
4multicellular organismal water homeostasisGO:005089110.4AQP1, AQP4
5coronary artery morphogenesisGO:006098210.0NRP1, VEGFA
6regulation of retinal ganglion cell axon guidanceGO:009025910.0NRP1, VEGFA
7VEGF-activated neuropilin signaling pathwayGO:003819010.0NRP1, VEGFA
8positive regulation of retinal ganglion cell axon guidanceGO:190233610.0NRP1, VEGFA
9positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.0KDR, VEGFA
10artery morphogenesisGO:00488449.9NRP1, VEGFA
11endothelial cell chemotaxisGO:00357679.9NRP1, VEGFA
12positive regulation of positive chemotaxisGO:00509279.9KDR, VEGFA
13positive regulation of focal adhesion assemblyGO:00518949.9KDR, VEGFA
14commissural neuron axon guidanceGO:00716799.8NRP1, VEGFA
15cell migration involved in sprouting angiogenesisGO:00020429.7KDR, NRP1, VEGFA
16positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.7FLT1, VEGFA
17positive regulation of endothelial cell migrationGO:00105959.7KDR, NRP1, VEGFA
18positive regulation of endothelial cell proliferationGO:00019389.6KDR, NRP1, VEGFA
19positive regulation of axon extension involved in axon guidanceGO:00488429.5NRP1, VEGFA
20positive regulation of MAPK cascadeGO:00434109.3FLT1, KDR, TNFRSF1B
21transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.2CD8A, FLT1, KDR
22positive regulation of angiogenesisGO:00457668.9AQP1, FLT1, KDR, VEGFA
23angiogenesisGO:00015258.8FLT1, KDR, NRP1, VEGFA
24cellular response to vascular endothelial growth factor stimulusGO:00359248.8FLT1, KDR, NRP1, VEGFA
25vascular endothelial growth factor receptor signaling pathwayGO:00480108.6FLT1, KDR, NRP1, VEGFA
26immune responseGO:00069557.5CD8A, FASLG, IL1RN, MBP, TNFRSF1A, TNFRSF1B

Molecular functions related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:000537210.6AQP1, AQP4
2water channel activityGO:001525010.6AQP1, AQP4
3glycerol channel activityGO:001525410.6AQP1, AQP4
4vascular endothelial growth factor-activated receptor activityGO:000502110.2FLT1, KDR, NRP1
5tumor necrosis factor-activated receptor activityGO:000503110.2TNFRSF1A, TNFRSF1B
6growth factor bindingGO:001983810.2FLT1, KDR, NRP1
7protein bindingGO:00055154.9AQP1, CD8A, CFI, FASLG, FLT1, IL1RN

Sources for Acute Hemorrhagic Leukoencephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet