MCID: ACT032
MIFTS: 29

Acute Hemorrhagic Leukoencephalitis malady

Rare diseases category

Summaries for Acute Hemorrhagic Leukoencephalitis

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NIH Rare Diseases:41 Acute hemorrhagic leukoencephalitis (ahl) is a very rare form of acute disseminated encephalomyelitis that usually results in death. it is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. it may also cause bleeding in the brain, leading to damage of the white matter. symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. ahl has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. although the exact cause is unclear, ahl usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to ahl. last updated: 8/19/2011

MalaCards based summary: Acute Hemorrhagic Leukoencephalitis, also known as ahl, is related to herpes simplex and brain injury. An important gene associated with Acute Hemorrhagic Leukoencephalitis is CFI (complement factor I). The compounds heparin and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum.

Disease Ontology:9 A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema.

Aliases & Classifications for Acute Hemorrhagic Leukoencephalitis

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Acute Hemorrhagic Leukoencephalitis, Aliases & Descriptions:

Name: Acute Hemorrhagic Leukoencephalitis 9 41 11
Ahl 9 41
Acute Haemorrhagic Leucoencephalitis of Weston Hurst 9
Acute Necrotizing Hemorrhagic Leukoencephalitis 9
 
Leukoencephalitis, Acute Hemorrhagic 60
Acute Hemorrhagic Encephalomyelitis 9
Weston-Hurst Syndrome 9
Ahle 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:10992
ICD9CM27 323.9
SNOMED-CT55 72986009
MeSH33 D004684
NCIt38 C84535

Related Diseases for Acute Hemorrhagic Leukoencephalitis

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Diseases related to Acute Hemorrhagic Leukoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex10.5
2brain injury10.3
3mumps10.3
4encephalitis10.3
5influenza10.3
6myopathy10.3
7tuberculosis10.3
8herpes simplex encephalitis10.3
9dementia10.0NRP1, CFI
10myeloid leukemia9.9NRP1, CFI
11primary hyperoxaluria9.9CFI, NRP1
12malignant glioma9.9NRP1, CFI
13ovarian cancer, somatic9.9NRP1, CFI
14rheumatoid arthritis9.9CFI, NRP1
15melanoma9.9CFI, NRP1
16colorectal cancer9.8NRP1, CFI
17alzheimer disease9.7NRP1, CFI

Graphical network of diseases related to Acute Hemorrhagic Leukoencephalitis:



Diseases related to acute hemorrhagic leukoencephalitis

Symptoms for Acute Hemorrhagic Leukoencephalitis

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Drugs & Therapeutics for Acute Hemorrhagic Leukoencephalitis

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Drug clinical trials:

Search ClinicalTrials for Acute Hemorrhagic Leukoencephalitis

Search NIH Clinical Center for Acute Hemorrhagic Leukoencephalitis

Genetic Tests for Acute Hemorrhagic Leukoencephalitis

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Anatomical Context for Acute Hemorrhagic Leukoencephalitis

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MalaCards organs/tissues related to Acute Hemorrhagic Leukoencephalitis:

31
Brain, Spinal cord, Cerebellum

Animal Models for Acute Hemorrhagic Leukoencephalitis or affiliated genes

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Publications for Acute Hemorrhagic Leukoencephalitis

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Articles related to Acute Hemorrhagic Leukoencephalitis:

(show all 46)
idTitleAuthorsYear
1
Acute hemorrhagic leukoencephalitis associated with autoimmune myopathy. (25422709)
2014
2
Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient. (24384347)
2014
3
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. (22926405)
2013
4
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection. (23508437)
2013
5
Value of susceptibility-weighted imaging in acute hemorrhagic leukoencephalitis. (22465779)
2012
6
Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. (21519996)
2011
7
Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation. (21448963)
2011
8
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. (20010289)
2010
9
Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion. (19847676)
2010
10
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
11
Acute hemorrhagic leukoencephalitis with atypical features. (19145402)
2009
12
Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. (19917982)
2009
13
Use of therapeutic plasma exchange in the management of acute hemorrhagic leukoencephalitis: a case report and review of the literature. (17524086)
2007
14
Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. (17608318)
2007
15
The importance of EEG and variability of MRI findings in acute hemorrhagic leukoencephalitis. (17038020)
2006
16
Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. (15917264)
2005
17
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report. (16155148)
2005
18
Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection. (15791481)
2005
19
Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. (16163044)
2005
20
Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report. (15122448)
2004
21
Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. (12601124)
2003
22
Acute hemorrhagic leukoencephalitis in male sibs. (11840490)
2002
23
Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. (12206493)
2002
24
Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis. (12402170)
2002
25
Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review. (11810602)
2002
26
Successful recovery after high-dose intravenous methylprednisolone in acute hemorrhagic leukoencephalitis. (11697528)
2001
27
Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). (11200696)
2000
28
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577083)
1999
29
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577082)
1999
30
Case 1-1999: Acute hemorrhagic leukoencephalitis. (10577084)
1999
31
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
32
Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. (9373802)
1997
33
Tubular inclusions in macrophages in the brain of a patient with acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome). (8191625)
1994
34
Acute hemorrhagic leukoencephalitis: a cause of acute brainstem dysfunction. (8052903)
1994
35
Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome. (1468137)
1992
36
Acute hemorrhagic leukoencephalitis. (1844176)
1991
37
Acute hemorrhagic leukoencephalitis. (1746242)
1991
38
Acute hemorrhagic leukoencephalitis. A successful recovery. (1929904)
1991
39
An autopsied case of acute hemorrhagic leukoencephalitis. (3773347)
1986
40
Acute hemorrhagic leukoencephalitis: diagnosis by computed tomography. (6742799)
1984
41
Computed tomography in acute hemorrhagic leukoencephalitis. (6721456)
1984
42
Computerized tomography as a diagnostic aid in acute hemorrhagic leukoencephalitis. (6847149)
1983
43
Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature. (1105376)
1975
44
Acute hemorrhagic leukoencephalitis. Report of 2 cases. (6016398)
1967
45
Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings. (4290137)
1967
46
ACUTE HEMORRHAGIC LEUKOENCEPHALITIS; A CLINICAL AND ELECTRON-MICROSCOPIC REPORT OF 2 PATIENTS TREATED WITH SURGICAL DECOMPRESSION. (14058421)
1963

Variations for Acute Hemorrhagic Leukoencephalitis

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Expression for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Search GEO for disease gene expression data for Acute Hemorrhagic Leukoencephalitis.

Pathways for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Compounds for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1heparin43 28 24 1212.2NRP1, CFI
2cholesterol43 28 24 1212.2NRP1, CFI
3estrogen439.1NRP1, CFI
4serine439.1NRP1, CFI
5glucose439.0CFI, NRP1
6lipid438.8NRP1, CFI

GO Terms for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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Cellular components related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.1NRP1, CFI

Molecular functions related to Acute Hemorrhagic Leukoencephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:00468729.1NRP1, CFI

Products for genes affiliated with Acute Hemorrhagic Leukoencephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acute Hemorrhagic Leukoencephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet