MCID: ACT088
MIFTS: 42

Acute Insulin Response malady

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Summaries for Acute Insulin Response

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MalaCards based summary: Acute Insulin Response is related to obesity and type 2 diabetes mellitus. An important gene associated with Acute Insulin Response is AIR (Acute insulin response (2)), and among its related pathways are The fatty acid cycling model and Potassium transporters inward current. The compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and pancreatic islet, and related mouse phenotypes are adipose tissue and behavior/neurological.

Aliases & Classifications for Acute Insulin Response

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Acute Insulin Response, Aliases & Descriptions:

Name: Acute Insulin Response 46


Related Diseases for Acute Insulin Response

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Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.0UCP1, ADRB2
2type 2 diabetes mellitus31.0TCF7L2, KCNJ11
3pancreatitis30.1INS, CRP, GCG
4polycystic ovary syndrome29.9GCG, INS, CRP
5hyperinsulinism29.8KCNJ5, ABCC8, KCNJ11, INS, UCP2, GCG
6atherosclerosis29.7INS, UCP1, UCP2, TCF7L2, CRP, ADRB2
7insulin resistance29.1ABCC8, INS, PYGM, ADRB2, TCF7L2, GCG
8diabetes mellitus28.9GCG, ABCC8, PYGM, KCNJ5, CRP, UCP2
9dumping syndrome10.4GCG
10permanent neonatal diabetes mellitus10.3INS, ABCC8
11hyperinsulinemic hypoglycemia10.3ABCC8, INS
12maturity-onset diabetes of the young10.3KCNJ11, INS
13gastroparesis10.2GCG, INS
14gastrinoma10.2GCG, PYGM
15morbid obesity10.2GCG, INS
16familial hyperinsulinism10.2GLUD1, KCNJ11, ABCC8
17lactic acidosis10.2GCG, INS
18sudden cardiac death multi-gene panels10.2KCNJ5, ADRB2
19autonomic neuropathy10.2INS, GCG
20hyperammonemia multi-gene panels10.2GLUD1, KCNJ11, ABCC8
21hypokalemia10.1INS, ADRB2
22hypopituitarism10.1GCG, INS
23hyperinsulinism-hyperammonemia syndrome10.1
24fatty liver disease10.1INS, UCP2, GLUD1
25glycogen storage disease10.1GCG, PYGM
26neonatal diabetes mellitus10.1ABCC8, KCNJ5, KCNJ11, INS
27chronic obstructive pulmonary disease10.0CRP, ADRB2
28bacteremia10.0CRP, GCG
29cholera10.0ADRB2, INS, GCG
30cystic fibrosis10.0ADRB2, INS, KCNJ11, ABCC8
31epilepsy syndrome10.0ABCC8, KCNJ5, KCNJ11, GLUD1
32glucose intolerance9.9INS, GCG
33type 1 diabetes mellitus9.9UCP1, GCG, INS, ADRB2
34septic shock9.9KCNJ5, CRP, ADRB2
35myopathy9.9INS, PYGM, CRP
36multiple sclerosis9.9UCP2, ADRB2, GLUD1
37congenital heart disease9.9ADRB2, CRP, INS
38parkinson's disease9.9KCNJ5, GLUD1, ADRB2
39diarrhea9.9INS, CRP, GCG
40primary hyperoxaluria9.9GCG, CRP, INS
41chronic kidney failure9.9CRP, UCP2, INS
42hypertension9.9INS, ADRB2, CRP
43galactosemia9.9CRP, GCG, INS
44familial hyperlipidemia9.9UCP2, UCP1, INS, CRP
45coronary artery anomaly9.8KCNJ5, CRP, ADRB2, ABCC8
46adenoma9.8INS, KCNJ5, TCF7L2, GCG
47gestational diabetes9.7TCF7L2, ABCC8, KCNJ11, GCG, INS
48acute myocardial infarction9.7CRP, ADRB2, GCG, KCNJ5
49myocardial infarction9.7CRP, GCG, KCNJ5, ADRB2
50ischemia9.7KCNJ5, ADRB2, GCG, ABCC8, GLUD1

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to acute insulin response

Symptoms for Acute Insulin Response

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Drugs & Therapeutics for Acute Insulin Response

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Drug clinical trials:

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Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

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Anatomical Context for Acute Insulin Response

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MalaCards organs/tissues related to Acute Insulin Response:

32
Testes, Ovary, Pancreatic islet

Animal Models for Acute Insulin Response or affiliated genes

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MGI Mouse Phenotypes related to Acute Insulin Response:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3KCNJ11, INS, ADRB2, TCF7L2, UCP1
2MP:00053868.1UCP2, UCP1, TCF7L2, ADRB2, INS, KCNJ11
3MP:00053857.5KCNJ5, KCNJ11, INS, ADRB2, UCP1, CRP
4MP:00053797.4ABCC8, KCNJ11, INS, ADRB2, TCF7L2, GLUD1
5MP:00053787.1KCNJ11, INS, ADRB2, TCF7L2, UCP1, UCP2
6MP:00053766.0GCG, ABCC8, KCNJ11, INS, ADRB2, TCF7L2

Publications for Acute Insulin Response

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Articles related to Acute Insulin Response:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Sitagliptin Improves the Impaired Acute Insulin Response during a Meal Tolerance Test in Japanese Patients with Type 2 Diabetes Mellitus: A Small-Scale Real-World Study. (24888256)
2014
2
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. (20888012)
2011
3
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. (21593106)
2011
4
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. (19368944)
2009
5
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). (19430760)
2009
6
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. (18261179)
2008
7
The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study. (18940402)
2008
8
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. (18796522)
2008
9
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. (18223616)
2008
10
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. (18509807)
2008
11
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. (17971425)
2008
12
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. (18460558)
2008
13
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. (17001619)
2007
14
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks: response to Hardy et al. (17596492)
2007
15
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. (17397545)
2007
16
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. (18049122)
2007
17
Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. (16567510)
2006
18
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. (16977256)
2006
19
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. (15880384)
2006
20
Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. (16132955)
2005
21
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. (16332653)
2005
22
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. (16353672)
2005
23
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. (14764815)
2004
24
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. (14715863)
2004
25
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. (14693408)
2004
26
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. (12637978)
2003
27
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. (12716738)
2003
28
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. (12364426)
2002
29
Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. (11916954)
2002
30
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. (10447516)
1999
31
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. (10517305)
1999
32
Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. (9500569)
1998
33
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. (9604878)
1998
34
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. (9619535)
1998
35
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. (9794097)
1998
36
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. (8971083)
1997
37
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. (9027510)
1997
38
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. (9392485)
1997
39
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. (8787683)
1996
40
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. (7698519)
1995
41
Acute insulin response to glucose and glucagon in subjects at risk of developing type I diabetes. (8359105)
1993
42
Comparison of bolus and infusion protocols for determining acute insulin response to intravenous glucose in normal humans. The ICARUS Group. Islet Cell Antibody Register User's Study. (8325205)
1993
43
Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics. (1761067)
1991
44
Acute insulin response to intravenous glucose, glucagon and arginine in some subjects at risk for type 1 (insulin-dependent) diabetes mellitus. (1955097)
1991
45
Inter and intra individual variability of acute insulin response during intravenous glucose tolerance tests. (2698364)
1989
46
Low acute insulin response to intravenous glucose. A sensitive but non-specific marker of early stages of type 1 (insulin-dependent) diabetes. (3065113)
1988
47
Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young. (3512209)
1986
48
A role for prostaglandins as mediators of alpha-adrenergic inhibition of the acute insulin response to glucose. (6246779)
1980
49
Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. (6255805)
1980
50
Acetylsalicyclic acid restores acute insulin response reduced by furosemide in man. (467810)
1979

Variations for Acute Insulin Response

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Expression for genes affiliated with Acute Insulin Response

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Expression patterns in normal tissues for genes affiliated with Acute Insulin Response

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Pathways for genes affiliated with Acute Insulin Response

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Pathways related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9UCP1, UCP2
29.8KCNJ11, KCNJ5
39.6ADRB2, INS
4
Show member pathways
FOXA transcription factor networks37
9.5INS, GCG
5
Show member pathways
9.5ABCC8, KCNJ5, KCNJ11
6
Show member pathways
9.5KCNJ11, KCNJ5, ABCC8
7
Show member pathways
9.5KCNJ11, KCNJ5, ABCC8
8
Show member pathways
9.5INS, KCNJ11, ABCC8
9
Show member pathways
9.4UCP1, ADRB2, PYGM
10
Show member pathways
9.3GCG, TCF7L2
119.1UCP2, INS, KCNJ11, ABCC8
129.0ABCC8, KCNJ5, KCNJ11, ADRB2
139.0GCG, GLUD1, INS
14
Show member pathways
8.9ABCC8, KCNJ11, INS, GCG
15
Show member pathways
8.9ABCC8, KCNJ11, INS, GCG
168.9CRP, UCP2, INS
17
Show member pathways
8.9GCG, TCF7L2, INS
18
Show member pathways
8.4PYGM, ADRB2, CRP, GCG
19
Show member pathways
7.5ABCC8, PYGM, KCNJ11, INS, UCP1, UCP2

Compounds for genes affiliated with Acute Insulin Response

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Compounds related to Acute Insulin Response according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1cibenzoline449.9KCNJ11, ABCC8
2nicorandil44 2810.9ABCC8, KCNJ5, KCNJ11
3mgadp449.9KCNJ5, ABCC8, KCNJ11
4cromakalim44 2810.8ABCC8, KCNJ11, KCNJ5
5minoxidil44 28 1111.8ABCC8, KCNJ5, KCNJ11
6benzopyran449.8KCNJ5, ABCC8
7gliclazide44 50 1111.7INS, ABCC8, KCNJ11
8glipizide44 50 1111.7KCNJ5, INS, ABCC8
9meglitinide449.6ABCC8, INS, GCG
10nateglinide44 50 1111.2ABCC8, KCNJ5, INS, GCG
11palmitate449.2UCP1, GCG, UCP2, INS
12pgd-m449.0CRP, GCG
13thiazolidinedione449.0CRP, INS, UCP2, UCP1
14bezafibrate44 28 1111.0UCP1, INS, UCP2, CRP
15glimepiride44 50 1111.0GCG, INS, KCNJ11, KCNJ5, ABCC8
16diazoxide44 61 28 1112.0GLUD1, INS, KCNJ11, KCNJ5, ABCC8
17rosiglitazone28 44 50 24 1112.9INS, UCP2, CRP, UCP1
18hydrogen44 249.8PYGM, ADRB2, UCP1, UCP2, GLUD1
19gtp44 289.8UCP2, GLUD1, ADRB2, UCP1, ABCC8
20gdp448.8ABCC8, ADRB2, UCP1, UCP2
21lysine448.7GLUD1, ADRB2, KCNJ11, KCNJ5, ABCC8
22superoxide44 249.7GLUD1, UCP1, ADRB2, KCNJ5, UCP2
23adp44 28 2410.6UCP2, UCP1, KCNJ11, ABCC8, KCNJ5, GLUD1
24potassium44 24 1110.6ABCC8, KCNJ11, KCNJ5, ADRB2, UCP2, GLUD1
25c-peptide448.6KCNJ11, GCG, CRP, UCP1, INS
26glycerol44 24 1110.6ADRB2, GLUD1, GCG, INS
27glibenclamide44 28 50 6111.5KCNJ11, INS, ADRB2, GCG, KCNJ5, ABCC8
28metformin44 50 1110.5ABCC8, KCNJ11, GCG, CRP, INS
29sulfonylurea448.5KCNJ11, KCNJ5, ABCC8, INS, GLUD1, GCG
30katp448.5ABCC8, KCNJ5, KCNJ11, GLUD1, GCG, INS
31tolbutamide44 28 50 1111.5INS, GLUD1, GCG, KCNJ11, KCNJ5, ABCC8
32fatty acid448.4INS, UCP1, UCP2, GLUD1, GCG, ABCC8
33atp44 289.4KCNJ11, ABCC8, GLUD1, UCP2, UCP1, PYGM
34repaglinide50 44 1110.4INS, ABCC8, KCNJ5, KCNJ11, TCF7L2, GCG
35glycogen44 249.4INS, ABCC8, GCG, UCP2, TCF7L2, PYGM
36oxygen44 249.3KCNJ5, GLUD1, UCP2, UCP1, ADRB2, ABCC8
37carnitine448.2GLUD1, PYGM, CRP, UCP2, UCP1, INS
38rapamycin448.1GCG, KCNJ5, CRP, INS, GLUD1
39aspartate448.1CRP, UCP1, ADRB2, KCNJ11, GLUD1, ABCC8
40acetylcholine44 50 28 24 1112.1KCNJ5, ADRB2, CRP, GLUD1, GCG
41arginine448.1PYGM, ADRB2, ABCC8, GLUD1, GCG, INS
42glutamine447.9UCP2, ADRB2, KCNJ11, GCG, GLUD1, CRP
43creatinine447.8PYGM, ADRB2, GCG, GLUD1, CRP, INS
44norepinephrine44 24 119.7UCP2, ADRB2, GCG, CRP, UCP1, KCNJ5
45glutamate447.7ADRB2, GLUD1, UCP1, INS, KCNJ11, KCNJ5
46testosterone44 61 24 1110.6KCNJ5, TCF7L2, ADRB2, INS, ABCC8, UCP1
47alanine447.5UCP1, GLUD1, UCP2, GCG, ADRB2, INS
48lactate447.2PYGM, INS, ADRB2, UCP2, CRP, GCG
49lipid446.7GCG, INS, TCF7L2, ABCC8, KCNJ5, ADRB2
50glucose445.4GCG, AIR, PYGM, KCNJ5, KCNJ11, INS

GO Terms for genes affiliated with Acute Insulin Response

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Cellular components related to Acute Insulin Response according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5GCG, INS
2voltage-gated potassium channel complexGO:0080769.2KCNJ11, KCNJ5, ABCC8

Biological processes related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial transportGO:00683910.0UCP2, UCP1
2proton transportGO:01599210.0UCP2, UCP1
3cellular response to glucose stimulusGO:07133310.0KCNJ11, UCP2
4brown fat cell differentiationGO:0508739.9UCP1, ADRB2
5glucose metabolic processGO:0060069.7PYGM, KCNJ11, INS
6potassium ion transmembrane transportGO:0718059.7KCNJ11, KCNJ5, ABCC8
7adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:0071889.5GCG, ADRB2
8positive regulation of protein bindingGO:0320929.3GCG, TCF7L2
9regulation of insulin secretionGO:0507969.2ABCC8, KCNJ11, INS, GCG
10energy reserve metabolic processGO:0061129.2ABCC8, KCNJ11, INS, GCG
11acute-phase responseGO:0069539.1CRP, INS
12positive regulation of insulin secretionGO:0320249.0GLUD1, TCF7L2
13small molecule metabolic processGO:0442817.8GCG, ABCC8, PYGM, KCNJ11, INS, UCP1

Products for genes affiliated with Acute Insulin Response

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Sources for Acute Insulin Response

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet