Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 53 13
Air 53 3

External Ids:

OMIM 53 601676

Summaries for Acute Insulin Response

CDC : 3 Outdoor air quality has improved since the 1990s, but many challenges remain in protecting Americans from air quality problems. Ground-level ozone, the main part of smog, and particle pollution are just two of the many threats to air quality and public health in the United States.

MalaCards based summary : Acute Insulin Response, also known as air, is related to hyperinsulinism and diabetes mellitus. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Liraglutide and Zinc have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreatic islet and pancreas, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Description from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinism 29.4 ABCC8 INS KCNJ11 KCNJ5 UCP2
2 diabetes mellitus 28.5 ABCC8 CRP GCG INS KCNJ11 TCF7L2
3 body mass index quantitative trait locus 11 27.6 ADRB2 CRP GCG INS UCP1 UCP2
4 diabetes mellitus, noninsulin-dependent 26.5 ABCC8 CRP GCG INS KCNJ11 PIK3R1
5 intellectual deficit buenos-aires type 12.2
6 mental retardation, buenos aires type 12.0
7 ventilation pneumonitis 11.8
8 pneumothorax, primary spontaneous 11.4
9 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.3
10 respiratory failure 11.3
11 bronchitis 11.2
12 pneumonia 11.2
13 lung disease 11.2
14 allergic rhinitis 11.2
15 interstitial lung disease 11.2
16 asthma 11.2
17 pneumothorax 11.1
18 sick building syndrome 11.1
19 streptococcal group a invasive disease 11.1
20 mycobacterium tuberculosis 1 11.1
21 pulmonary disease, chronic obstructive 11.1
22 lymphangioleiomyomatosis 11.1
23 bronchiectasis 11.1
24 q fever 11.1
25 autoimmune retinopathy 11.1
26 bronchiolitis 11.0
27 influenza 11.0
28 autoimmune polyendocrine syndrome type 1 11.0
29 sinusitis 11.0
30 pneumocystosis 11.0
31 pulmonary edema 11.0
32 newborn respiratory distress syndrome 11.0
33 acute respiratory distress syndrome 11.0
34 tracheoesophageal fistula 11.0
35 panbronchiolitis, diffuse 10.9
36 porphyria, acute hepatic 10.9
37 sleep apnea 10.9
38 pollen allergy 10.9
39 legionnaires' disease 10.9
40 coccidioidomycosis 10.9
41 measles 10.9
42 acute mountain sickness 10.9
43 laryngocele 10.9
44 mastoiditis 10.9
45 pleural disease 10.9
46 cryptogenic organizing pneumonia 10.9
47 infantile apnea 10.9
48 emphysema, congenital lobar 10.8
49 alkaptonuria 10.8
50 pulmonary alveolar microlithiasis 10.8

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 INS PIK3R1 TCF7L2

MGI Mouse Phenotypes related to Acute Insulin Response:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
2 adipose tissue MP:0005375 9.63 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
3 muscle MP:0005369 9.1 PYGM TCF7L2 ADRB2 INS KCNJ11 PIK3R1

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 138)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2 44147092
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
3
Clozapine Approved Phase 4 5786-21-0 2818
4
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
5
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
6
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
7
Protein C Approved Phase 4
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
10
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
11
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
12
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
13
Phytonadione Approved, Investigational, Nutraceutical Phase 4 84-80-0 5284607 4812
14 Menatetrenone Investigational Phase 4 863-61-6
15 Hormone Antagonists Phase 4,Phase 2,Phase 1
16 Hormones Phase 4,Phase 2,Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
18 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Incretins Phase 4,Phase 2,Phase 1
20 insulin Phase 4,Phase 3,Phase 2,Phase 1
21 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1
22 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2
23 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
24
protease inhibitors Phase 4,Phase 3,Phase 2
25 Sitagliptin Phosphate Phase 4,Phase 2
26 Antifibrinolytic Agents Phase 4
27 Coagulants Phase 4
28 Hemostatics Phase 4
29 Micronutrients Phase 4
30 Trace Elements Phase 4
31 Vitamin K 2 Phase 4
32 Vitamin MK 7 Phase 4
33 Vitamins Phase 4
34 Antipsychotic Agents Phase 4
35 Central Nervous System Depressants Phase 4
36 GABA Agents Phase 4
37 Neurotransmitter Agents Phase 4
38 Psychotropic Drugs Phase 4
39
Serotonin Phase 4 50-67-9 5202
40 Serotonin Agents Phase 4
41 Serotonin Antagonists Phase 4
42 Tranquilizing Agents Phase 4
43 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function Unknown status NCT01790308 Phase 4 CSII;Liraglutide
2 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4 Sitagliptin
3 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
4 Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment Completed NCT00337350 Phase 4 rosiglitazone;placebo
5 Pioglitazone Incretin Study Completed NCT00656864 Phase 4 Pioglitazone;Placebo
6 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
7 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Active, not recruiting NCT01475513 Phase 4 Ortho Cyclen®
8 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Not yet recruiting NCT02198209 Phase 4 Liraglutide
9 Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3 Colesevelam
10 A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes Completed NCT00312130 Phase 3 Vildagliptin
11 Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects Completed NCT00787878 Phase 3 somatropin;No treatment given;No treatment given
12 Diet and Medical Therapy Versus Bariatric Surgery in Type 2 Diabetes Completed NCT00888836 Phase 2, Phase 3
13 Islet Transplantation in Type 1 Diabetes Completed NCT00434811 Phase 3 Sirolimus;Tacrolimus
14 Incretin Effect and Use After Clinical Islet Transplantation Completed NCT00768651 Phase 2 Pantoprazole;Sitagliptin
15 Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes Completed NCT00434850 Phase 2 Deoxyspergualin;Sirolimus;Tacrolimus
16 Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation Completed NCT00789308 Phase 2 Low Molecular Weight Sulfated Dextran (LMW-SD);Heparin;CellCept® (Mycophenolate mofetil) OR Rapamune® (Sirolimus);Prograf® (Tacrolimus) OR Cyclosporine;Thymoglobulin® (Anti-thymocyte Globulin) - at first transplant;Simulect® (Basiliximab) - at 2nd or 3rd transplant;Klexane® (Enoxaparinsodium);Trombyl® or Albyl-E® (Acetylsalicylicacid- ASA);Enbrel® (Etanercept)
17 LEA29Y (Belatacept) Emory Edmonton Protocol Completed NCT00468403 Phase 2 Mycophenolate Mofetil;Tacrolimus
18 Omental Islet Transplant Recruiting NCT02821026 Phase 1, Phase 2 Anti-Thymocyte Globulin;Mycophenolate mofetil;Tacrolimus;Etanercept;Sirolimus
19 Exenatide and Weight Loss for Diabetes Prevention Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
20 Islet Allotransplantation in Type 1 Diabetes Enrolling by invitation NCT01705899 Phase 1 Human Pancreatic Islets
21 Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients Unknown status NCT01588743 insulin aspart
22 Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes Completed NCT00981448
23 Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old Completed NCT00843232
24 Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery Completed NCT01271062
25 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly Completed NCT00843479
26 Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients Completed NCT01147627 exenatide injection;Mixed Protamine Zinc Recombinant Human Insulin Lispro 25R;Pioglitazone
27 Sucralose Effects on Glucose Metabolism and Gut Microbiota Completed NCT02650947
28 Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass Completed NCT00775684 Exenatide;Sitagliptin;Glimepiride
29 Role of Pancreatic Triglyceride Content in Beta-cell Function Completed NCT00602953
30 Chromium Picolinate for the Treatment of Metabolic Syndrome Completed NCT00128154 Chromium picolinate
31 Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed NCT01503164
32 Sleep Loss and Mechanisms of Impaired Glucose Metabolism Completed NCT00555750 eszopiclone;placebo
33 Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function Recruiting NCT03264001
34 Epigenetic Regulation of Human Adipose Tissue Distribution Recruiting NCT02728635
35 Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects. Recruiting NCT03332927
36 Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes Recruiting NCT03202680

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

38
Liver, Pancreatic Islet, Pancreas, Testes, Ovary

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 66)
# Title Authors Year
1
Decline in the Acute Insulin Response in Relationship to Plasma Glucose Concentrations. ( 28948712 )
2017
2
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control. ( 25475437 )
2015
3
Sitagliptin Improves the Impaired Acute Insulin Response during a Meal Tolerance Test in Japanese Patients with Type 2 Diabetes Mellitus: A Small-Scale Real-World Study. ( 24888256 )
2014
4
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. ( 20888012 )
2011
5
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. ( 21593106 )
2011
6
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). ( 19430760 )
2009
7
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. ( 19368944 )
2009
8
Childhood predictors of adult acute insulin response and insulin action. ( 19228868 )
2009
9
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. ( 18223616 )
2008
10
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. ( 17971425 )
2008
11
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. ( 18796522 )
2008
12
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. ( 18261179 )
2008
13
The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study. ( 18940402 )
2008
14
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. ( 18509807 )
2008
15
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. ( 18460558 )
2008
16
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks. ( 17192353 )
2007
17
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. ( 17397545 )
2007
18
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. ( 18049122 )
2007
19
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. ( 17001619 )
2007
20
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks: response to Hardy et al. ( 17596492 )
2007
21
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. ( 16977256 )
2006
22
Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. ( 16567510 )
2006
23
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. ( 15880384 )
2006
24
Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. ( 16132955 )
2005
25
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. ( 16332653 )
2005
26
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. ( 16353672 )
2005
27
Suppression of body weight gain preserves acute insulin response to glucose in the portal vein of spontaneously type 2 diabetic rats with visceral obesity. ( 15888925 )
2005
28
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. ( 14693408 )
2004
29
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. ( 14764815 )
2004
30
The insulin sensitivity, glucose effectiveness and acute insulin response to glucose load of non-obese adolescent type 2 diabetes. ( 15536022 )
2004
31
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. ( 14715863 )
2004
32
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. ( 12716738 )
2003
33
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. ( 12637978 )
2003
34
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT. ( 12582008 )
2003
35
The effect of surgical stress on insulin sensitivity, glucose effectiveness and acute insulin response to glucose load. ( 12906365 )
2003
36
Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. ( 11916954 )
2002
37
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. ( 12364426 )
2002
38
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome. ( 11502802 )
2001
39
Acute insulin response to intravenous arginine in nonobese healthy cats. ( 10587254 )
1999
40
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. ( 10517305 )
1999
41
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. ( 10447516 )
1999
42
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. ( 9619535 )
1998
43
Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. ( 9500569 )
1998
44
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. ( 9794097 )
1998
45
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. ( 9604878 )
1998
46
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. ( 9392485 )
1997
47
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. ( 9027510 )
1997
48
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. ( 8971083 )
1997
49
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. ( 8787683 )
1996
50
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. ( 7698519 )
1995

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 ABCC8 ADRB2 GCG INS KCNJ11 KCNJ5
2 12.22 GCG INS UCP1 UCP2
3
Show member pathways
12.07 ABCC8 GCG INS KCNJ11
4
Show member pathways
11.96 GCG INS TCF7L2
5
Show member pathways
11.86 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.73 ABCC8 KCNJ11 KCNJ5
7
Show member pathways
11.67 INS PIK3R1 PYGM
8
Show member pathways
11.54 ABCC8 INS KCNJ11 PIK3R1
9 11.28 ADRB2 INS PIK3R1
10 11.21 ABCC8 KCNJ11 PIK3R1
11 11 ABCC8 ADRB2 KCNJ11 KCNJ5
12
Show member pathways
10.65 UCP1 UCP2
13 10.57 ABCC8 INS KCNJ11 UCP2

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.13 ABCC8 KCNJ11 KCNJ5
2 inward rectifying potassium channel GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.65 INS PIK3R1 TCF7L2
2 potassium ion transport GO:0006813 9.63 ABCC8 KCNJ11 KCNJ5
3 positive regulation of glucose import GO:0046326 9.54 INS PIK3R1
4 negative regulation of insulin secretion GO:0046676 9.52 ABCC8 KCNJ11
5 brown fat cell differentiation GO:0050873 9.51 ADRB2 UCP1
6 potassium ion import GO:0010107 9.49 KCNJ11 KCNJ5
7 cellular glucose homeostasis GO:0001678 9.43 ABCC8 PIK3R1
8 regulation of insulin secretion GO:0050796 9.43 ABCC8 GCG KCNJ11
9 regulation of protein localization to plasma membrane GO:1903076 9.4 INS PIK3R1
10 negative regulation of blood vessel diameter GO:0097756 9.37 CRP INS
11 diet induced thermogenesis GO:0002024 9.32 ADRB2 UCP1
12 adaptive thermogenesis GO:1990845 9.16 UCP1 UCP2
13 response to cold GO:0009409 9.13 ADRB2 UCP1 UCP2
14 mitochondrial transmembrane transport GO:1990542 8.62 UCP1 UCP2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 INS PIK3R1
2 inward rectifier potassium channel activity GO:0005242 9.26 KCNJ11 KCNJ5
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS PIK3R1
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
5 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP1 UCP2

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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