MCID: ACT088
MIFTS: 41

Acute Insulin Response malady

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Summaries for Acute Insulin Response

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MalaCards: Acute Insulin Response is related to obesity and type 2 diabetes mellitus. An important gene associated with Acute Insulin Response is AIR (Acute insulin response (2)), and among its related pathways are The fatty acid cycling model and Potassium transporters inward current. The compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and pancreatic islet, and related mouse phenotypes are adipose tissue and behavior/neurological.

Aliases & Classifications for Acute Insulin Response

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47OMIM
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Aliases & Descriptions:

acute insulin response 47


Related Diseases for Acute Insulin Response

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17GeneCards, 18GeneDecks
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Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.7UCP1, ADRB2
2type 2 diabetes mellitus30.6TCF7L2, KCNJ11
3atherosclerosis30.4INS, ADRB2, TCF7L2, UCP1, UCP2, CRP
4hyperinsulinism30.4ABCC8, KCNJ5, KCNJ11, INS, UCP2, GLUD1
5insulin resistance30.3ABCC8, PYGM, INS, ADRB2, TCF7L2, UCP1
6pancreatitis30.3GCG, CRP, INS
7diabetes mellitus30.1GCG, CRP, UCP2, ABCC8, PYGM, KCNJ5
8polycystic ovary syndrome30.1INS, CRP, GCG
9dumping syndrome10.1GCG
10permanent neonatal diabetes mellitus10.1INS, ABCC8
11hyperinsulinism-hyperammonemia syndrome10.1
12hyperinsulinemic hypoglycemia10.1INS, ABCC8
13maturity-onset diabetes of the young10.1KCNJ11, INS
14gastroparesis10.0GCG, INS
15gastrinoma10.0GCG, PYGM
16morbid obesity10.0INS, GCG
17familial hyperinsulinism10.0ABCC8, KCNJ11, GLUD1
18lactic acidosis10.0INS, GCG
19sudden cardiac death multi-gene panels10.0ADRB2, KCNJ5
20autonomic neuropathy10.0INS, GCG
21hyperammonemia multi-gene panels10.0ABCC8, KCNJ11, GLUD1
22hypokalemia10.0INS, ADRB2
23hypopituitarism10.0INS, GCG
24fatty liver disease10.0INS, UCP2, GLUD1
25glycogen storage disease10.0GCG, PYGM
26neonatal diabetes mellitus10.0ABCC8, KCNJ5, KCNJ11, INS
27pulmonary disease, chronic obstructive10.0CRP, ADRB2
28bacteremia10.0CRP, GCG
29cystic fibrosis10.0ABCC8, KCNJ11, INS, ADRB2
30cholera10.0INS, ADRB2, GCG
31epilepsy syndrome10.0GLUD1, KCNJ11, KCNJ5, ABCC8
32glucose intolerance10.0GCG, INS
33type 1 diabetes mellitus10.0INS, ADRB2, UCP1, GCG
34hypertrophy of breast10.0GCG, UCP1, ADRB2, KCNJ5
35septic shock10.0CRP, ADRB2, KCNJ5
36myopathy10.0PYGM, INS, CRP
37multiple sclerosis10.0GLUD1, UCP2, ADRB2
38congenital heart disease10.0INS, ADRB2, CRP
39parkinson's disease10.0KCNJ5, ADRB2, GLUD1
40diarrhea10.0INS, CRP, GCG
41primary hyperoxaluria10.0GCG, CRP, INS
42chronic kidney failure10.0INS, UCP2, CRP
43hypertension10.0CRP, ADRB2, INS
44galactosemia10.0INS, CRP, GCG
45familial hyperlipidemia10.0CRP, UCP2, UCP1, INS
46coronary artery disease9.9CRP, ADRB2, KCNJ5, ABCC8
47adenoma9.9GCG, TCF7L2, INS, KCNJ5
48gestational diabetes9.9GCG, TCF7L2, INS, KCNJ11, ABCC8
49acute myocardial infarction9.9KCNJ5, ADRB2, CRP, GCG
50myocardial infarction9.9KCNJ5, ADRB2, CRP, GCG

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to acute insulin response

Symptoms for Acute Insulin Response

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Drugs & Therapeutics for Acute Insulin Response

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Acute Insulin Response

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

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Anatomical Context for Acute Insulin Response

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33MalaCards
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MalaCards organs/tissues related to Acute Insulin Response:

33
Testes, Ovary, Pancreatic islet

Animal Models for Acute Insulin Response or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Insulin Response:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3KCNJ11, INS, ADRB2, TCF7L2, UCP1
2MP:00053868.1UCP2, UCP1, TCF7L2, ADRB2, INS, KCNJ11
3MP:00053857.5KCNJ5, KCNJ11, INS, ADRB2, UCP1, CRP
4MP:00053797.4ABCC8, KCNJ11, INS, ADRB2, TCF7L2, GLUD1
5MP:00053787.1KCNJ11, INS, ADRB2, TCF7L2, UCP1, UCP2
6MP:00053766.0GCG, ABCC8, KCNJ11, INS, ADRB2, TCF7L2

Publications for Acute Insulin Response

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52PubMed
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Articles related to Acute Insulin Response:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. (20888012)
2011
2
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. (21593106)
2011
3
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. (19368944)
2009
4
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). (19430760)
2009
5
Childhood predictors of adult acute insulin response and insulin action. (19228868)
2009
6
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. (18261179)
2008
7
The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study. (18940402)
2008
8
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. (18796522)
2008
9
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. (18223616)
2008
10
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. (18509807)
2008
11
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. (17971425)
2008
12
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. (18460558)
2008
13
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. (17001619)
2007
14
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks: response to Hardy et al. (17596492)
2007
15
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. (17397545)
2007
16
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. (18049122)
2007
17
Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. (16567510)
2006
18
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. (16977256)
2006
19
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. (15880384)
2006
20
Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. (16132955)
2005
21
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. (16332653)
2005
22
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. (16353672)
2005
23
Suppression of body weight gain preserves acute insulin response to glucose in the portal vein of spontaneously type 2 diabetic rats with visceral obesity. (15888925)
2005
24
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. (14764815)
2004
25
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. (14715863)
2004
26
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. (14693408)
2004
27
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. (12637978)
2003
28
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. (12716738)
2003
29
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. (12364426)
2002
30
Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. (11916954)
2002
31
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. (10447516)
1999
32
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. (10517305)
1999
33
Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. (9500569)
1998
34
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. (9604878)
1998
35
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. (9619535)
1998
36
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. (9794097)
1998
37
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. (8971083)
1997
38
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. (9027510)
1997
39
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. (9392485)
1997
40
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. (8787683)
1996
41
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. (7698519)
1995
42
Acute insulin response to glucose and glucagon in subjects at risk of developing type I diabetes. (8359105)
1993
43
Comparison of bolus and infusion protocols for determining acute insulin response to intravenous glucose in normal humans. The ICARUS Group. Islet Cell Antibody Register User's Study. (8325205)
1993
44
Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics. (1761067)
1991
45
Acute insulin response to intravenous glucose, glucagon and arginine in some subjects at risk for type 1 (insulin-dependent) diabetes mellitus. (1955097)
1991
46
Inter and intra individual variability of acute insulin response during intravenous glucose tolerance tests. (2698364)
1989
47
Low acute insulin response to intravenous glucose. A sensitive but non-specific marker of early stages of type 1 (insulin-dependent) diabetes. (3065113)
1988
48
Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young. (3512209)
1986
49
A role for prostaglandins as mediators of alpha-adrenergic inhibition of the acute insulin response to glucose. (6246779)
1980
50
Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. (6255805)
1980

Variations for Acute Insulin Response

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Expression for genes affiliated with Acute Insulin Response

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for genes affiliated with Acute Insulin Response

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50PathCards, 55Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 60Thomson Reuters, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9UCP1, UCP2
29.8KCNJ11, KCNJ5
39.6ADRB2, INS
4
Show member pathways
FOXA transcription factor networks38
9.5INS, GCG
5
Show member pathways
9.5ABCC8, KCNJ5, KCNJ11
6
Show member pathways
9.5KCNJ11, KCNJ5, ABCC8
7
Show member pathways
9.5KCNJ11, KCNJ5, ABCC8
8
Show member pathways
9.5INS, KCNJ11, ABCC8
9
Show member pathways
9.4UCP1, ADRB2, PYGM
10
Show member pathways
9.3GCG, TCF7L2
119.1UCP2, INS, KCNJ11, ABCC8
129.0ABCC8, KCNJ5, KCNJ11, ADRB2
139.0GCG, GLUD1, INS
14
Show member pathways
8.9ABCC8, KCNJ11, INS, GCG
15
Show member pathways
8.9ABCC8, KCNJ11, INS, GCG
168.9CRP, UCP2, INS
17
Show member pathways
8.9GCG, TCF7L2, INS
18
Show member pathways
8.4PYGM, ADRB2, CRP, GCG
19
Show member pathways
7.5ABCC8, PYGM, KCNJ11, INS, UCP1, UCP2

Compounds for genes affiliated with Acute Insulin Response

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Acute Insulin Response according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1cibenzoline459.9KCNJ11, ABCC8
2nicorandil45 2910.9ABCC8, KCNJ5, KCNJ11
3mgadp459.9KCNJ5, ABCC8, KCNJ11
4cromakalim45 2910.8ABCC8, KCNJ11, KCNJ5
5minoxidil45 29 1111.8ABCC8, KCNJ5, KCNJ11
6benzopyran459.8KCNJ5, ABCC8
7gliclazide45 51 1111.7INS, ABCC8, KCNJ11
8glipizide45 51 1111.7KCNJ5, INS, ABCC8
9meglitinide459.6ABCC8, INS, GCG
10nateglinide45 51 1111.2ABCC8, KCNJ5, INS, GCG
11palmitate459.2UCP1, GCG, UCP2, INS
12pgd-m459.0CRP, GCG
13thiazolidinedione459.0CRP, INS, UCP2, UCP1
14bezafibrate45 29 1111.0UCP1, INS, UCP2, CRP
15glimepiride45 51 1111.0GCG, INS, KCNJ11, KCNJ5, ABCC8
16diazoxide45 61 29 1112.0GLUD1, INS, KCNJ11, KCNJ5, ABCC8
17rosiglitazone29 45 51 24 1112.9INS, UCP2, CRP, UCP1
18hydrogen45 249.8PYGM, ADRB2, UCP1, UCP2, GLUD1
19gtp45 299.8UCP2, GLUD1, ADRB2, UCP1, ABCC8
20gdp458.8ABCC8, ADRB2, UCP1, UCP2
21lysine458.7GLUD1, ADRB2, KCNJ11, KCNJ5, ABCC8
22superoxide45 249.7GLUD1, UCP1, ADRB2, KCNJ5, UCP2
23adp45 29 2410.6UCP2, UCP1, KCNJ11, ABCC8, KCNJ5, GLUD1
24potassium45 24 1110.6ABCC8, KCNJ11, KCNJ5, ADRB2, UCP2, GLUD1
25c-peptide458.6KCNJ11, GCG, CRP, UCP1, INS
26glycerol45 24 1110.6ADRB2, GLUD1, GCG, INS
27glibenclamide45 29 51 6111.5KCNJ11, INS, ADRB2, GCG, KCNJ5, ABCC8
28metformin45 51 1110.5ABCC8, KCNJ11, GCG, CRP, INS
29sulfonylurea458.5KCNJ11, KCNJ5, ABCC8, INS, GLUD1, GCG
30katp458.5ABCC8, KCNJ5, KCNJ11, GLUD1, GCG, INS
31tolbutamide45 29 51 1111.5INS, GLUD1, GCG, KCNJ11, KCNJ5, ABCC8
32fatty acid458.4INS, UCP1, UCP2, GLUD1, GCG, ABCC8
33atp45 299.4KCNJ11, ABCC8, GLUD1, UCP2, UCP1, PYGM
34repaglinide51 45 1110.4INS, ABCC8, KCNJ5, KCNJ11, TCF7L2, GCG
35glycogen45 249.4INS, ABCC8, GCG, UCP2, TCF7L2, PYGM
36oxygen45 249.3KCNJ5, GLUD1, UCP2, UCP1, ADRB2, ABCC8
37carnitine458.2GLUD1, PYGM, CRP, UCP2, UCP1, INS
38rapamycin458.1GCG, KCNJ5, CRP, INS, GLUD1
39aspartate458.1CRP, UCP1, ADRB2, KCNJ11, GLUD1, ABCC8
40acetylcholine45 51 29 24 1112.1KCNJ5, ADRB2, CRP, GLUD1, GCG
41arginine458.1PYGM, ADRB2, ABCC8, GLUD1, GCG, INS
42glutamine457.9UCP2, ADRB2, KCNJ11, GCG, GLUD1, CRP
43creatinine457.8PYGM, ADRB2, GCG, GLUD1, CRP, INS
44norepinephrine45 24 119.7UCP2, ADRB2, GCG, CRP, UCP1, KCNJ5
45glutamate457.7ADRB2, GLUD1, UCP1, INS, KCNJ11, KCNJ5
46testosterone45 61 24 1110.6KCNJ5, TCF7L2, ADRB2, INS, ABCC8, UCP1
47alanine457.5UCP1, GLUD1, UCP2, GCG, ADRB2, INS
48lactate457.2PYGM, INS, ADRB2, UCP2, CRP, GCG
49lipid456.7GCG, INS, TCF7L2, ABCC8, KCNJ5, ADRB2
50glucose455.4GCG, AIR, PYGM, KCNJ5, KCNJ11, INS

GO Terms for genes affiliated with Acute Insulin Response

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16Gene Ontology
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Cellular components related to Acute Insulin Response according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5GCG, INS
2voltage-gated potassium channel complexGO:0080769.2KCNJ11, KCNJ5, ABCC8

Biological processes related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial transportGO:00683910.0UCP2, UCP1
2proton transportGO:01599210.0UCP2, UCP1
3cellular response to glucose stimulusGO:07133310.0KCNJ11, UCP2
4brown fat cell differentiationGO:0508739.9UCP1, ADRB2
5glucose metabolic processGO:0060069.7PYGM, KCNJ11, INS
6potassium ion transmembrane transportGO:0718059.7KCNJ11, KCNJ5, ABCC8
7adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:0071889.5GCG, ADRB2
8positive regulation of protein bindingGO:0320929.3GCG, TCF7L2
9regulation of insulin secretionGO:0507969.2ABCC8, KCNJ11, INS, GCG
10energy reserve metabolic processGO:0061129.2ABCC8, KCNJ11, INS, GCG
11acute-phase responseGO:0069539.1CRP, INS
12positive regulation of insulin secretionGO:0320249.0GLUD1, TCF7L2
13small molecule metabolic processGO:0442817.8GCG, ABCC8, PYGM, KCNJ11, INS, UCP1

Products for genes affiliated with Acute Insulin Response

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  • Antibodies
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Sources for Acute Insulin Response

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet