MCID: ACT088
MIFTS: 35

Acute Insulin Response malady

Summaries for Acute Insulin Response

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33MalaCards
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MalaCards: Acute Insulin Response is related to insulin resistance and atherosclerosis. An important gene associated with Acute Insulin Response is AIR (Acute insulin response (2)), and among its related pathways are ATP sensitive Potassium channels and The fatty acid cycling model. The compounds minoxidil and cibenzoline have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and pancreatic islet, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Aliases & Classifications for Acute Insulin Response

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47OMIM
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Aliases & Descriptions:

acute insulin response 47


Related Diseases for Acute Insulin Response

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.6ADRB2, TCF7L2, ABCC8, INS, CRP, UCP1
2atherosclerosis30.5UCP2, UCP1, CRP, INS, TCF7L2, ADRB2
3hyperinsulinism30.5KCNJ11, GCG, UCP2, GLUD1, INS, ABCC8
4hyperinsulinism-hyperammonemia syndrome30.1GLUD1
5polycystic ovary syndrome30.0GCG, CRP, INS
6hyperinsulinism, diffuse10.2
7hyperinsulinism, focal10.2
8down syndrome10.0KCNJ5
9acromegaly10.0INS
10beckwith-wiedemann syndrome10.0ABCC8
11lipodystrophy10.0INS
12hepatitis10.0GLUD1
13blindness10.0INS
14neuropathy10.0INS
15wermer syndrome10.0PYGM
16maturity-onset diabetes of the young10.0INS, KCNJ11
17metabolic syndrome x10.0INS
18hyperhomocysteinemia10.0CRP
19uremia10.0CRP
20permanent neonatal diabetes mellitus10.0INS, ABCC8
21adenocarcinoma10.0UCP2, ADRB2
22anorexia nervosa10.0GCG
23hyperinsulinemic hypoglycemia10.0ABCC8, INS
24acanthosis nigricans10.0INS
25type 2 diabetes mellitus10.0TCF7L2, KCNJ11
26schizophrenia10.0GLUD1, INS
27essential hypertension10.0ADRB2, INS
28hypokalemia10.0INS, ADRB2
29dumping syndrome10.0GCG
30obesity10.0UCP1, ADRB2
31hypercholesterolemia10.0INS, CRP
32familial hyperinsulinism10.0ABCC8, GLUD1, KCNJ11
33hyperammonemia multi-gene panels10.0KCNJ11, GLUD1, ABCC8
34glycogen storage disease10.0PYGM, GCG
35glucose intolerance10.0GCG, INS
36gastrinoma10.0PYGM, GCG
37neonatal diabetes mellitus10.0ABCC8, INS, KCNJ11, KCNJ5
38glucagonoma10.0GCG
39hypopituitarism10.0GCG, INS
40fatty liver disease10.0INS, GLUD1, UCP2
41epilepsy syndrome10.0ABCC8, GLUD1, KCNJ11, KCNJ5
42hypertension10.0ADRB2, INS, CRP
43septic shock10.0ADRB2, CRP, KCNJ5
44morbid obesity10.0INS, GCG
45bacteremia10.0CRP, GCG
46prostate cancer10.0TCF7L2, ADRB2
47cystic fibrosis10.0KCNJ11, INS, ABCC8, ADRB2
48sudden cardiac death multi-gene panels10.0ADRB2, KCNJ5
49familial hyperlipidemia10.0UCP2, UCP1, CRP, INS
50ischemic heart disease10.0KCNJ5, CRP, ABCC8, ADRB2

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to acute insulin response

Clinical Features for Acute Insulin Response

Drugs & Therapeutics for Acute Insulin Response

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acute Insulin Response

Search CenterWatch for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Insulin Response:

33
Ovary, Lung, Pancreatic islet

Animal Models for Acute Insulin Response or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Insulin Response:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.0ADRB2, TCF7L2, INS, UCP1, KCNJ11
2MP:00053797.3ADRB2, KCNJ11, GCG, GLUD1, INS, TCF7L2
3MP:00053787.0KCNJ11, GCG, UCP2, UCP1, GLUD1, INS
4MP:00053765.9ADRB2, GLUD1, INS, ABCC8, TCF7L2, UCP1

Publications for Acute Insulin Response

Sources:
51PubMed
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Articles related to Acute Insulin Response:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury. (23622115)
2013
2
Response to comment on: Wolpert et al. Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management. Diabetes Care 2013;36:810-816. (24265381)
2013
3
Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration. (23422767)
2012
4
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. (20888012)
2011
5
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. (21593106)
2011
6
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. (19368944)
2009
7
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). (19430760)
2009
8
Childhood predictors of adult acute insulin response and insulin action. (19228868)
2009
9
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. (18261179)
2008
10
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. (18796522)
2008
11
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. (18223616)
2008
12
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. (18509807)
2008
13
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. (17971425)
2008
14
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. (18460558)
2008
15
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. (17397545)
2007
16
Effect of insulin on the inflammatory and acute phase response after burn injury. (17713402)
2007
17
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks. (17192353)
2007
18
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. (16977256)
2006
19
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. (15880384)
2006
20
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. (16353672)
2005
21
Suppression of body weight gain preserves acute insulin response to glucose in the portal vein of spontaneously type 2 diabetic rats with visceral obesity. (15888925)
2005
22
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. (14764815)
2004
23
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. (14715863)
2004
24
The insulin sensitivity, glucose effectiveness and acute insulin response to glucose load of non-obese adolescent type 2 diabetes. (15536022)
2004
25
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. (12637978)
2003
26
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. (12716738)
2003
27
The effect of surgical stress on insulin sensitivity, glucose effectiveness and acute insulin response to glucose load. (12906365)
2003
28
The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis. (11908557)
2002
29
Growth hormone/insulin-like growth factor-1 response to acute and chronic growth hormone-releasing peptide-2, growth hormone-releasing hormone 1-44NH2 and in combination in older men and women with decreased growth hormone secretion. (11322505)
2001
30
Insulin resistance in patients with cancer: relationships with tumor site, tumor stage, body-weight loss, acute-phase response, and energy expenditure. (11448578)
2001
31
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome. (11502802)
2001
32
Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children. (10674617)
2000
33
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. (10447516)
1999
34
Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans. (10022415)
1999
35
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. (9604878)
1998
36
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. (9619535)
1998
37
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. (9794097)
1998
38
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. (8971083)
1997
39
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. (9027510)
1997
40
Growth hormone and insulin-like growth factor I responses to moderate submaximal acute physical exercise in man: effects of octreotide, a somatostatin analogue, administration. (9231841)
1997
41
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. (9392485)
1997
42
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. (8787683)
1996
43
A comparative study of responses to acute hypoglycaemia induced by human and porcine insulins in patients with Type 1 diabetes. (9162611)
1996
44
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. (7698519)
1995
45
Acute insulin response to glucose and glucagon in subjects at risk of developing type I diabetes. (8359105)
1993
46
Androgen responses to acutely increased endogenous insulin levels in hyperandrogenic and normal cycling women. (1825813)
1991
47
Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young. (3512209)
1986
48
Acetylsalicyclic acid restores acute insulin response reduced by furosemide in man. (467810)
1979
49
Glucose infusion potentiates the acute insulin response to nonglucose stimuli during the infusion of somatostatin. (488008)
1979
50
The effect of rate and dose of glucose infusion on the acute insulin response in man. (932179)
1976

Genetic Variations for Acute Insulin Response

Expression for genes affiliated with Acute Insulin Response

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for genes affiliated with Acute Insulin Response

Sources:
54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Acute Insulin Response

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Acute Insulin Response according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1minoxidil45 29 1112.2KCNJ5, ABCC8
2cibenzoline4510.1KCNJ11, ABCC8
3benzopyran4510.1ABCC8, KCNJ5
4nicorandil45 2911.0KCNJ11, ABCC8, KCNJ5
5mgadp4510.0KCNJ11, KCNJ5, ABCC8
6norepinephrine45 11 2411.9UCP2, UCP1, KCNJ5
7cromakalim45 2910.9ABCC8, KCNJ11, KCNJ5
8Glyburide119.9ABCC8, KCNJ11, KCNJ5
9dicyandiamide459.9KCNJ5, ABCC8
10glipizide45 1110.8ABCC8, KCNJ5, INS
11gliclazide45 50 1111.8ABCC8, INS, KCNJ11
12palmitate459.7UCP2, UCP1, INS
13meglitinide459.6GCG, INS, ABCC8
14pgd-m459.4CRP, GCG
15nateglinide45 50 1111.3ABCC8, INS, GCG, KCNJ5
16diazoxide45 60 29 1112.1GLUD1, INS, KCNJ11, KCNJ5, ABCC8
17glimepiride45 50 1111.1ABCC8, INS, GCG, KCNJ11, KCNJ5
18superoxide45 2410.0UCP1, GLUD1, KCNJ5
19thiazolidinedione459.0INS, CRP, UCP1, UCP2
20bezafibrate45 29 1111.0CRP, UCP2, UCP1, INS
21gdp458.9ADRB2, UCP2, ABCC8, UCP1
22rosiglitazone45 50 29 11 2412.8UCP2, CRP, UCP1, INS
23potassium45 11 2410.7UCP2, KCNJ5, KCNJ11, ABCC8, ADRB2, GLUD1
24gtp45 299.7UCP1, UCP2, GLUD1, ABCC8, ADRB2
25sulfonylurea458.6ABCC8, GCG, KCNJ11, GLUD1, KCNJ5, INS
26katp458.6GLUD1, GCG, KCNJ5, KCNJ11, ABCC8, INS
27tolbutamide45 50 29 1111.6INS, KCNJ5, ABCC8, GLUD1, GCG, KCNJ11
28lysine458.6KCNJ5, KCNJ11, ADRB2, GLUD1, ABCC8
29hydrogen45 249.6UCP2, UCP1, ADRB2, GLUD1, PYGM
30glibenclamide45 29 50 6011.6ADRB2, ABCC8, INS, KCNJ5, KCNJ11, GCG
31metformin45 50 1110.6ABCC8, INS, GCG, CRP, KCNJ11
32adp45 29 2410.5ABCC8, GLUD1, UCP1, UCP2, KCNJ11, KCNJ5
33c-peptide458.5KCNJ11, GCG, CRP, UCP1, INS
34repaglinide45 50 1110.5KCNJ5, KCNJ11, GCG, INS, ABCC8, TCF7L2
35fatty acid458.5UCP2, GLUD1, UCP1, INS, GCG, ABCC8
36atp45 299.4KCNJ11, UCP1, GLUD1, KCNJ5, PYGM, UCP2
37glycogen45 249.4TCF7L2, ABCC8, INS, GCG, UCP2, PYGM
38rapamycin458.2INS, KCNJ5, GCG, CRP, GLUD1
39carnitine458.2INS, GLUD1, CRP, UCP1, UCP2, PYGM
40acetylcholine45 50 29 11 2412.1GCG, KCNJ5, CRP, GLUD1, ADRB2
41aspartate458.0KCNJ11, UCP1, CRP, ABCC8, ADRB2, GLUD1
42arginine458.0GLUD1, ABCC8, PYGM, ADRB2, KCNJ11, INS
43glutamine458.0KCNJ11, UCP2, CRP, GLUD1, ADRB2, GCG
44creatinine457.7GCG, PYGM, ADRB2, INS, GLUD1, CRP
45glutamate457.7ADRB2, ABCC8, INS, GLUD1, UCP1, KCNJ11
46testosterone45 60 11 2410.5UCP1, CRP, KCNJ5, ADRB2, TCF7L2, ABCC8
47alanine457.4INS, ADRB2, CRP, UCP1, UCP2, GCG
48lactate457.2ADRB2, INS, GLUD1, KCNJ5, GCG, PYGM
49lipid456.7CRP, INS, TCF7L2, ADRB2, ABCC8, UCP1
50glucose455.4TCF7L2, INS, ABCC8, ADRB2, UCP2, GLUD1

GO Terms for genes affiliated with Acute Insulin Response

Sources:
16Gene Ontology
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Cellular components related to Acute Insulin Response according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5INS, GCG
2voltage-gated potassium channel complexGO:0080769.3ABCC8, KCNJ11, KCNJ5

Biological processes related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial transportGO:0068399.7UCP2, UCP1
2brown fat cell differentiationGO:0508739.6ADRB2, UCP1
3proton transportGO:0159929.5UCP1, UCP2
4glucose metabolic processGO:0060069.5INS, PYGM, KCNJ11
5regulation of insulin secretionGO:0507969.1ABCC8, INS, GCG, KCNJ11
6energy reserve metabolic processGO:0061129.0KCNJ11, GCG, INS, ABCC8
7small molecule metabolic processGO:0442817.6ABCC8, KCNJ11, GCG, PYGM, UCP2, UCP1

Products for genes affiliated with Acute Insulin Response

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  • Proteins
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Sources for Acute Insulin Response

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet