MCID: ACT088
MIFTS: 30

Acute Insulin Response malady

Summaries for Acute Insulin Response

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32MalaCards
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MalaCards: Acute Insulin Response is related to atherosclerosis and obesity. An important gene associated with Acute Insulin Response is AIR (Acute insulin response (2)), and among its related pathways are ATP sensitive Potassium channels and The fatty acid cycling model. The compounds minoxidil and cibenzoline have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Aliases & Classifications for Acute Insulin Response

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46OMIM
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Aliases & Descriptions:

acute insulin response 46


Related Diseases for Acute Insulin Response

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17GeneCards, 18GeneDecks
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Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.5UCP1, CRP, ADRB2, UCP2, TCF7L2, INS
2obesity30.5ADRB2, UCP1
3hyperinsulinism30.5ABCC8, GLUD1, INS, UCP2, GCG, KCNJ11
4diabetes mellitus30.4TCF7L2, INS, CRP, UCP1, UCP2, PYGM
5type 2 diabetes mellitus30.4TCF7L2, KCNJ11
6pancreatitis30.2CRP, INS, GCG
7polycystic ovary syndrome30.0CRP, INS, GCG
8acute pancreatitis10.2
9type 1 diabetes mellitus10.0
10down syndrome10.0KCNJ5
11acromegaly10.0INS
12beckwith-wiedemann syndrome10.0ABCC8
13lipodystrophy10.0INS
14hyperinsulinism-hyperammonemia syndrome10.0GLUD1
15hepatitis10.0GLUD1
16blindness10.0INS
17neuropathy10.0INS
18wermer syndrome10.0PYGM
19maturity-onset diabetes of the young10.0KCNJ11, INS
20metabolic syndrome x10.0INS
21hyperhomocysteinemia10.0CRP
22uremia10.0CRP
23permanent neonatal diabetes mellitus10.0ABCC8, INS
24adenocarcinoma10.0ADRB2, UCP2
25anorexia nervosa10.0GCG
26hyperinsulinemic hypoglycemia10.0ABCC8, INS
27acanthosis nigricans10.0INS
28schizophrenia10.0GLUD1, INS
29essential hypertension10.0INS, ADRB2
30hypokalemia10.0ADRB2, INS
31dumping syndrome10.0GCG
32hypercholesterolemia10.0INS, CRP
33familial hyperinsulinism10.0GLUD1, KCNJ11, ABCC8
34hyperammonemia multi-gene panels10.0KCNJ11, GLUD1, ABCC8
35glycogen storage disease10.0PYGM, GCG
36glucose intolerance10.0INS, GCG
37gastrinoma10.0PYGM, GCG
38neonatal diabetes mellitus10.0ABCC8, INS, KCNJ5, KCNJ11
39glucagonoma10.0GCG
40hypopituitarism10.0GCG, INS
41fatty liver disease10.0INS, UCP2, GLUD1
42epilepsy syndrome10.0GLUD1, ABCC8, KCNJ5, KCNJ11
43hypertension10.0ADRB2, CRP, INS
44septic shock10.0ADRB2, KCNJ5, CRP
45morbid obesity10.0GCG, INS
46bacteremia10.0GCG, CRP
47prostate cancer10.0ADRB2, TCF7L2
48cystic fibrosis10.0ABCC8, INS, KCNJ11, ADRB2
49sudden cardiac death multi-gene panels10.0KCNJ5, ADRB2
50familial hyperlipidemia10.0UCP2, UCP1, INS, CRP

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to acute insulin response

Clinical Features for Acute Insulin Response

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Drugs & Therapeutics for Acute Insulin Response

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acute Insulin Response

Search CenterWatch for Acute Insulin Response

Genetic Tests for Acute Insulin Response

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Anatomical Context for Acute Insulin Response

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Animal Models for Acute Insulin Response or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Insulin Response:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.0KCNJ11, UCP1, INS, TCF7L2, ADRB2
2MP:00053797.3KCNJ11, GCG, GLUD1, INS, ABCC8, TCF7L2
3MP:00053787.0GCG, UCP2, UCP1, GLUD1, INS, TCF7L2
4MP:00053765.9ADRB2, KCNJ11, GCG, UCP2, UCP1, CRP

Publications for Acute Insulin Response

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Genetic Variations for Acute Insulin Response

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Expression for genes affiliated with Acute Insulin Response

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for genes affiliated with Acute Insulin Response

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53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Acute Insulin Response

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Insulin Response according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1minoxidil44 28 1112.2KCNJ5, ABCC8
2cibenzoline4410.1KCNJ11, ABCC8
3benzopyran4410.1ABCC8, KCNJ5
4nicorandil44 2811.0KCNJ11, ABCC8, KCNJ5
5mgadp4410.0KCNJ11, KCNJ5, ABCC8
6norepinephrine44 11 2411.9UCP2, UCP1, KCNJ5
7cromakalim44 2810.9ABCC8, KCNJ11, KCNJ5
8Glyburide119.9ABCC8, KCNJ11, KCNJ5
9dicyandiamide449.9KCNJ5, ABCC8
10glipizide44 1110.8ABCC8, KCNJ5, INS
11gliclazide44 49 1111.8ABCC8, INS, KCNJ11
12palmitate449.7UCP2, UCP1, INS
13meglitinide449.6GCG, INS, ABCC8
14pgd-m449.4CRP, GCG
15nateglinide44 49 1111.3ABCC8, INS, GCG, KCNJ5
16diazoxide44 59 28 1112.1GLUD1, INS, KCNJ11, KCNJ5, ABCC8
17glimepiride44 49 1111.1ABCC8, INS, GCG, KCNJ11, KCNJ5
18superoxide44 2410.0UCP1, GLUD1, KCNJ5
19thiazolidinedione449.0INS, CRP, UCP1, UCP2
20bezafibrate44 28 1111.0CRP, UCP2, UCP1, INS
21gdp448.9ADRB2, UCP2, ABCC8, UCP1
22rosiglitazone44 49 28 11 2412.8UCP2, CRP, UCP1, INS
23potassium44 11 2410.7UCP2, KCNJ5, KCNJ11, ABCC8, ADRB2, GLUD1
24gtp44 289.7UCP1, UCP2, GLUD1, ABCC8, ADRB2
25sulfonylurea448.6ABCC8, GCG, KCNJ11, GLUD1, KCNJ5, INS
26katp448.6GLUD1, GCG, KCNJ5, KCNJ11, ABCC8, INS
27tolbutamide44 49 28 1111.6INS, KCNJ5, ABCC8, GLUD1, GCG, KCNJ11
28lysine448.6KCNJ5, KCNJ11, ADRB2, GLUD1, ABCC8
29hydrogen44 249.6UCP2, UCP1, ADRB2, GLUD1, PYGM
30glibenclamide44 28 49 5911.6ADRB2, ABCC8, INS, KCNJ5, KCNJ11, GCG
31metformin44 49 1110.6ABCC8, INS, GCG, CRP, KCNJ11
32adp44 28 2410.5ABCC8, GLUD1, UCP1, UCP2, KCNJ11, KCNJ5
33c-peptide448.5KCNJ11, GCG, CRP, UCP1, INS
34repaglinide44 49 1110.5KCNJ5, KCNJ11, GCG, INS, ABCC8, TCF7L2
35fatty acid448.5UCP2, GLUD1, UCP1, INS, GCG, ABCC8
36atp44 289.4KCNJ11, UCP1, GLUD1, KCNJ5, PYGM, UCP2
37glycogen44 249.4TCF7L2, ABCC8, INS, GCG, UCP2, PYGM
38rapamycin448.2INS, KCNJ5, GCG, CRP, GLUD1
39carnitine448.2INS, GLUD1, CRP, UCP1, UCP2, PYGM
40acetylcholine44 49 28 11 2412.1GCG, KCNJ5, CRP, GLUD1, ADRB2
41aspartate448.0KCNJ11, UCP1, CRP, ABCC8, ADRB2, GLUD1
42arginine448.0GLUD1, ABCC8, PYGM, ADRB2, KCNJ11, INS
43glutamine448.0KCNJ11, UCP2, CRP, GLUD1, ADRB2, GCG
44creatinine447.7GCG, PYGM, ADRB2, INS, GLUD1, CRP
45glutamate447.7ADRB2, ABCC8, INS, GLUD1, UCP1, KCNJ11
46testosterone44 59 11 2410.5UCP1, CRP, KCNJ5, ADRB2, TCF7L2, ABCC8
47alanine447.4INS, ADRB2, CRP, UCP1, UCP2, GCG
48lactate447.2ADRB2, INS, GLUD1, KCNJ5, GCG, PYGM
49lipid446.7CRP, INS, TCF7L2, ADRB2, ABCC8, UCP1
50glucose445.4TCF7L2, INS, ABCC8, ADRB2, UCP2, GLUD1

GO Terms for genes affiliated with Acute Insulin Response

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16Gene Ontology
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Cellular components related to Acute Insulin Response according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5INS, GCG
2voltage-gated potassium channel complexGO:0080769.3ABCC8, KCNJ11, KCNJ5

Biological processes related to Acute Insulin Response according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial transportGO:0068399.7UCP2, UCP1
2brown fat cell differentiationGO:0508739.6ADRB2, UCP1
3proton transportGO:0159929.5UCP2, UCP1
4glucose metabolic processGO:0060069.5INS, KCNJ11, PYGM
5regulation of insulin secretionGO:0507969.1INS, GCG, KCNJ11, ABCC8
6energy reserve metabolic processGO:0061129.0KCNJ11, GCG, INS, ABCC8
7small molecule metabolic processGO:0442817.6INS, UCP1, GLUD1, PYGM, ABCC8, GCG

Products for genes affiliated with Acute Insulin Response

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Insulin Response

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet