MCID: ACT088
MIFTS: 39

Acute Insulin Response malady

Aliases & Classifications for Acute Insulin Response

Aliases & Descriptions for Acute Insulin Response:

Name: Acute Insulin Response 54 13

External Ids:

OMIM 54 601676

Summaries for Acute Insulin Response

MalaCards based summary : Acute Insulin Response is related to nosophobia and noonan syndrome 3. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Glucose / Energy Metabolism and Insulin secretion. The drugs Liraglutide and Diazoxide have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreatic islet and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Description from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
id Related Disease Score Top Affiliating Genes
1 nosophobia 10.2 ABCC8 KCNJ11
2 noonan syndrome 3 10.2 ABCC8 KCNJ11
3 image syndrome 10.2 INS KCNJ5
4 ritscher-schinzel syndrome 2 10.2 ABCC8 KCNJ11
5 alopecia-mental retardation syndrome 2 10.2 ABCC8 INS
6 labyrinthine unilateral reactive loss 10.2 ABCC8 INS KCNJ11
7 microphthalmia, syndromic 8 10.2 GCG INS
8 mosaic trisomy 13 10.2 ABCC8 INS KCNJ11
9 non-syndromic intellectual disability 10.2 ABCC8 INS KCNJ11
10 acute infection of pinna 10.2 CRP INS
11 diabetic cataract 10.2 ABCC8 INS KCNJ11
12 focal segmental glomerulosclerosis 8 10.2 ABCC8 INS KCNJ11
13 deafness, autosomal recessive 66 10.2 ABCC8 INS KCNJ11
14 anuria 10.1 ABCC8 INS PYGM
15 hemorrhagic fever 10.1 ABCC8 KCNJ11
16 cataract 10.1 CRP INS
17 antidepressant type abuse 10.1 INS KCNJ11 TCF7L2
18 parapharyngeal meningioma 10.1 CRP INS
19 peripheral degeneration of cornea 10.1 GCG INS
20 ischemic heart disease 10.0 ABCC8 GCG INS
21 distal muscular dystrophy 10.0 ABCC8 INS KCNJ11 KCNJ5
22 hyperlipoproteinemia type iv 10.0 CRP INS TCF7L2
23 neurogenic arthropathy 10.0 ABCC8 GCG INS KCNJ11
24 brain stem glioma 10.0 ABCC8 GCG INS KCNJ11
25 mucopolysaccharidosis iii 10.0 CRP GCG INS
26 blind loop syndrome 9.9 CRP GCG INS
27 exostosis 9.9 ABCC8 INS KCNJ11 KCNJ5 UCP2
28 hyperphenylalaninemia, bh4-deficient, b 9.9 GCG PYGM
29 maturity-onset diabetes of the young, type 13 9.9 ABCC8 GCG INS KCNJ11 UCP2
30 atherosclerosis 9.8
31 obesity 9.8
32 hyperinsulinism 9.8
33 chondroma 9.8 ABCC8 CRP GCG INS KCNJ11
34 congenital stationary night blindness 9.8 ABCC8 CRP GCG INS KCNJ11
35 pancreatitis 9.6
36 adrenal adenoma 9.6 CRP GCG INS UCP1 UCP2
37 peroneal neuropathy 9.6 ABCC8 CRP GCG INS KCNJ11 TCF7L2
38 hyperinsulinism-hyperammonemia syndrome 9.5
39 polycystic ovary syndrome 9.5
40 hyperammonemia 9.5
41 body dysmorphic disorder 9.2 ABCC8 CRP GCG INS KCNJ11 TCF7L2
42 von hippel-lindau syndrome 9.2 ABCC8 ADRB2 CRP GCG INS UCP1
43 maturity-onset diabetes of the young 6 9.1 ABCC8 CRP GCG INS KCNJ11 PIK3R1
44 autoimmune disease 1 8.4 ABCC8 ADRB2 AIR CRP GCG INS

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 INS PIK3R1 TCF7L2

MGI Mouse Phenotypes related to Acute Insulin Response:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
2 adipose tissue MP:0005375 9.63 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
3 muscle MP:0005369 9.1 KCNJ11 PIK3R1 PYGM TCF7L2 ADRB2 INS

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2
2
Diazoxide Approved Phase 4 364-98-7 3019
3
Glimepiride Approved Phase 4 93479-97-1 3476
4
Oxymetazoline Approved Phase 4 1491-59-4 4636
5
Phenylephrine Approved Phase 4 59-42-7 6041
6
Saxagliptin Approved Phase 4 361442-04-8 11243969
7
Citalopram Approved Phase 4 59729-33-8 2771
8
Insulin Aspart Approved Phase 4 116094-23-6 16132418
9
Zinc Approved Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
10
Clozapine Approved Phase 4 5786-21-0 2818
11
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
12
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
13
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
14
Heparin Approved, Investigational Phase 4,Phase 2,Phase 1 9005-49-6 772 46507594
15
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
16
Bisoprolol Approved Phase 4 66722-44-9 2405
17
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
18
Nitric Oxide Approved Phase 4 10102-43-9 145068
19
Ramipril Approved Phase 4 87333-19-5 5362129
20
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 657-24-9 14219 4091
21
Ezetimibe Approved Phase 4 163222-33-1 150311
22
Simvastatin Approved Phase 4 79902-63-9 54454
23
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
24
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
25
Exenatide Approved, Investigational Phase 4,Phase 1 141758-74-9 15991534
26
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
27
Benzocaine Approved Phase 4,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
28
Insulin Glargine Approved Phase 4 160337-95-1
29
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
30
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
31
Norgestimate Approved Phase 4 35189-28-7 6540478
32
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
33
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
34
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
35
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
36
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
37
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
38
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
39
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
40 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 1
41
Butyric Acid Experimental Phase 4 107-92-6 264
42 Glucagon-Like Peptide 1 Phase 4
43 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Hormones Phase 4,Phase 2,Phase 3,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
46 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Incretins Phase 4,Phase 3,Phase 2,Phase 1
48 Liver Extracts Phase 4,Phase 2,Phase 3,Phase 1
49 insulin Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 224)
id Name Status NCT ID Phase
1 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Unknown status NCT02198209 Phase 4
2 Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function Unknown status NCT01790308 Phase 4
3 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4
4 Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp" Unknown status NCT01660386 Phase 4
5 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4
6 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4
7 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4
8 Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment Completed NCT00337350 Phase 4
9 Pioglitazone Incretin Study Completed NCT00656864 Phase 4
10 Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance Completed NCT00835120 Phase 4
11 Early Prediction of Clinical Response in Patients With Schizophrenia Treated by Paliperidone ER Completed NCT02075528 Phase 4
12 Veterans Inpatient Insulin Study and Transition to Outpatient Therapy Completed NCT00821795 Phase 4
13 Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease Completed NCT03011775 Phase 4
14 Can Vitamin D Supplementation Prevent Type 2 Diabetes? Completed NCT02112721 Phase 4
15 The Effect of Liraglutide on the Treatment of Coronary Artery Disease and Type 2 Diabetes Completed NCT01595789 Phase 4
16 Additive Effect of Ezetimibe Upon Simvastatin During Myocardial Infarction Completed NCT00905905 Phase 4
17 Exubera Large Simple Trial To Evaluate Long-Term Pulmonary And Cardiovascular Safety Completed NCT00359801 Phase 4
18 Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant Completed NCT01186562 Phase 4
19 A Pilot Trial to Evaluate the Effect of Diet and Exercise in Renal Transplant Recipients on Tacrolimus Completed NCT00492661 Phase 4
20 Clinical Trial to Evaluate the Use of an Adsorption Membrane (OXIRIS®) During Cardiopulmonary Bypass Surgery Completed NCT02398019 Phase 4
21 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4
22 Exenatide Inpatient Trial: A Randomized Controlled Pilot Trial on the Safety and Efficacy of Exenatide (Byetta®) Therapy for the Inpatient Management of Patients With Type 2 Diabetes Recruiting NCT02455076 Phase 4
23 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Active, not recruiting NCT01475513 Phase 4
24 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4
25 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4
26 The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication Terminated NCT01799057 Phase 4
27 Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock Unknown status NCT01858909 Phase 3
28 Targeting Inflammation Using Salsalate in CardioVascular Disease Unknown status NCT00624923 Phase 2, Phase 3
29 Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3
30 A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes Completed NCT00312130 Phase 3
31 Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects Completed NCT00787878 Phase 3
32 Diet and Medical Therapy Versus Bariatric Surgery in Type 2 Diabetes Completed NCT00888836 Phase 2, Phase 3
33 Islet Transplantation in Type 1 Diabetes Completed NCT00434811 Phase 3
34 Carbohydrates and Proteins 3h Before Surgery Completed NCT01563965 Phase 3
35 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3
36 Mechanisms of Improved Wound Healing and Protein Synthesis of Insulin and Metformin Recruiting NCT01666665 Phase 2, Phase 3
37 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Recruiting NCT02451033 Phase 2, Phase 3
38 Prevention of Cystic Fibrosis Diabetes Terminated NCT00967798 Phase 3
39 Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate Withdrawn NCT00732485 Phase 2, Phase 3
40 Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Unknown status NCT01503164 Phase 2
41 Dietary Intervention in Diabetes Mellitus (DIDM)- Intermediate and Acute Effects Unknown status NCT01585818 Phase 2
42 Safety and Efficacy of Mesenchymal Stem Cells in Newly-diagnosed Type 1 Diabetic Patients Unknown status NCT01322789 Phase 1, Phase 2
43 Incretin Effect and Use After Clinical Islet Transplantation Completed NCT00768651 Phase 2
44 Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes Completed NCT00434850 Phase 2
45 Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation Completed NCT00789308 Phase 2
46 LEA29Y (Belatacept) Emory Edmonton Protocol Completed NCT00468403 Phase 2
47 Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects Completed NCT02245906 Phase 1, Phase 2
48 Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects Completed NCT02035241 Phase 1, Phase 2
49 Effects of Berry Peel Intake on Glucose Metabolism in Healthy Subjects Completed NCT02533986 Phase 1, Phase 2
50 Dose-response Study to Evaluate Safety, Efficacy, and Pharmacokinetics of PF-00217830 Compared With Placebo in Acute Exacerbation of Schizophrenia Completed NCT00580125 Phase 2

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

39
Testes, Pancreatic Islet, Ovary

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 65)
id Title Authors Year
1
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control. ( 25475437 )
2015
2
Sitagliptin Improves the Impaired Acute Insulin Response during a Meal Tolerance Test in Japanese Patients with Type 2 Diabetes Mellitus: A Small-Scale Real-World Study. ( 24888256 )
2014
3
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. ( 20888012 )
2011
4
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. ( 21593106 )
2011
5
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). ( 19430760 )
2009
6
Childhood predictors of adult acute insulin response and insulin action. ( 19228868 )
2009
7
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. ( 19368944 )
2009
8
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. ( 18460558 )
2008
9
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. ( 18796522 )
2008
10
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. ( 17971425 )
2008
11
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. ( 18261179 )
2008
12
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. ( 18509807 )
2008
13
The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study. ( 18940402 )
2008
14
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. ( 18223616 )
2008
15
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. ( 18049122 )
2007
16
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks. ( 17192353 )
2007
17
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. ( 17397545 )
2007
18
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks: response to Hardy et al. ( 17596492 )
2007
19
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. ( 17001619 )
2007
20
Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. ( 16567510 )
2006
21
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. ( 16977256 )
2006
22
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. ( 15880384 )
2006
23
Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. ( 16132955 )
2005
24
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. ( 16353672 )
2005
25
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. ( 16332653 )
2005
26
Suppression of body weight gain preserves acute insulin response to glucose in the portal vein of spontaneously type 2 diabetic rats with visceral obesity. ( 15888925 )
2005
27
The insulin sensitivity, glucose effectiveness and acute insulin response to glucose load of non-obese adolescent type 2 diabetes. ( 15536022 )
2004
28
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. ( 14715863 )
2004
29
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. ( 14764815 )
2004
30
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. ( 14693408 )
2004
31
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. ( 12637978 )
2003
32
The effect of surgical stress on insulin sensitivity, glucose effectiveness and acute insulin response to glucose load. ( 12906365 )
2003
33
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. ( 12716738 )
2003
34
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT. ( 12582008 )
2003
35
Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. ( 11916954 )
2002
36
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. ( 12364426 )
2002
37
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome. ( 11502802 )
2001
38
Acute insulin response to intravenous arginine in nonobese healthy cats. ( 10587254 )
1999
39
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. ( 10517305 )
1999
40
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. ( 10447516 )
1999
41
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. ( 9794097 )
1998
42
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. ( 9604878 )
1998
43
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. ( 9619535 )
1998
44
Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. ( 9500569 )
1998
45
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. ( 9027510 )
1997
46
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. ( 8971083 )
1997
47
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. ( 9392485 )
1997
48
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. ( 8787683 )
1996
49
Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose. ( 7666784 )
1995
50
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. ( 7698519 )
1995

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1 12.2 GCG INS UCP1 UCP2
2
Show member pathways
12.1 ABCC8 GCG INS KCNJ11
3
Show member pathways
12.03 ABCC8 GCG INS KCNJ11
4
Show member pathways
11.96 GCG INS TCF7L2
5
Show member pathways
11.86 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.73 ABCC8 KCNJ11 KCNJ5
7
Show member pathways
11.67 INS PIK3R1 PYGM
8
Show member pathways
11.44 ABCC8 INS KCNJ11 PIK3R1
9 11.23 ADRB2 INS PIK3R1
10 11.15 ABCC8 KCNJ11 PIK3R1
11 11 ABCC8 ADRB2 KCNJ11 KCNJ5
12
Show member pathways
10.65 UCP1 UCP2
13 10.57 ABCC8 INS KCNJ11 UCP2

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.13 ABCC8 KCNJ11 KCNJ5
2 ATP-sensitive potassium channel complex GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.61 ABCC8 KCNJ11 KCNJ5
2 acute-phase response GO:0006953 9.52 CRP INS
3 brown fat cell differentiation GO:0050873 9.51 ADRB2 UCP1
4 regulation of insulin secretion GO:0050796 9.5 ABCC8 GCG KCNJ11
5 negative regulation of insulin secretion GO:0046676 9.49 ABCC8 KCNJ11
6 positive regulation of glucose import GO:0046326 9.48 INS PIK3R1
7 potassium ion import GO:0010107 9.46 KCNJ11 KCNJ5
8 cellular glucose homeostasis GO:0001678 9.4 ABCC8 PIK3R1
9 diet induced thermogenesis GO:0002024 9.37 ADRB2 UCP1
10 negative regulation of vasodilation GO:0045908 9.26 CRP INS
11 adaptive thermogenesis GO:1990845 9.16 UCP1 UCP2
12 response to cold GO:0009409 9.13 ADRB2 UCP1 UCP2
13 mitochondrial transmembrane transport GO:1990542 8.62 UCP1 UCP2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 INS PIK3R1
2 inward rectifier potassium channel activity GO:0005242 9.26 KCNJ11 KCNJ5
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS PIK3R1
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
5 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP1 UCP2

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....